Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dihydropyrimidinase activity	DPYSL2 DPYSL3 DPYSL4	1.32e-06	6	82	3	GO:0004157
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	DPYSL2 DPYSL3 DPYSL4	3.60e-05	16	82	3	GO:0016812
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	TBX18 ZNF132 ZSCAN32 ZNF671 ZSCAN12 ZNF154 ZSCAN31 ZNF780A MTOR ZSCAN26 ZNF189 ZSCAN9 ZNF616 ZNF691	6.23e-04	1271	82	14	GO:0000987
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	7.34e-04	10	82	2	GO:0001849
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	TBX18 ZNF132 ZNF133 ZSCAN32 ZNF671 ZSCAN12 ZNF154 ZSCAN31 ZNF780A ZNF566 ZSCAN26 ZNF189 ZSCAN9 ZNF616 ZNF691	7.97e-04	1459	82	15	GO:0000977
GeneOntologyBiologicalProcess	pyrimidine nucleobase metabolic process	DPYSL2 DPYSL3 MTOR DPYSL4	1.61e-06	22	82	4	GO:0006206
GeneOntologyBiologicalProcess	pyrimidine nucleobase catabolic process	DPYSL2 DPYSL3 DPYSL4	3.34e-06	8	82	3	GO:0006208
GeneOntologyBiologicalProcess	nucleobase catabolic process	DPYSL2 DPYSL3 DPYSL4	1.68e-05	13	82	3	GO:0046113
GeneOntologyBiologicalProcess	nucleobase metabolic process	DPYSL2 DPYSL3 MTOR DPYSL4	3.05e-05	45	82	4	GO:0009112
GeneOntologyBiologicalProcess	negative regulation of lysosome organization	MTOR FLCN	9.32e-05	4	82	2	GO:1905672
MousePheno	abnormal brown adipose tissue thermogenesis	OMA1 ACOT11 SLC25A48	1.98e-05	13	59	3	MP:0011699
Domain	ZINC_FINGER_C2H2_2	TRERF1 ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZSCAN31 ZNF780A ZNF804B ZNF566 ZSCAN26 ZBTB8B ZNF189 ZSCAN9 ZNF616 ZNF691	8.47e-08	775	77	16	PS50157
Domain	ZINC_FINGER_C2H2_1	TRERF1 ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZSCAN31 ZNF780A ZNF804B ZNF566 ZSCAN26 ZBTB8B ZNF189 ZSCAN9 ZNF616 ZNF691	8.77e-08	777	77	16	PS00028
Domain	-	TRERF1 ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZSCAN31 ZNF780A ZNF566 ZSCAN26 ZBTB8B ZNF189 ZSCAN9 ZNF616 ZNF691	9.55e-08	679	77	15	3.30.160.60
Domain	Znf_C2H2-like	TRERF1 ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZSCAN31 ZNF780A ZNF804B ZNF566 ZSCAN26 ZBTB8B ZNF189 ZSCAN9 ZNF616 ZNF691	1.22e-07	796	77	16	IPR015880
Domain	zf-C2H2	TRERF1 ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZSCAN31 ZNF780A ZNF566 ZSCAN26 ZBTB8B ZNF189 ZSCAN9 ZNF616 ZNF691	1.24e-07	693	77	15	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	TRERF1 ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZSCAN31 ZNF780A ZNF566 ZSCAN26 ZBTB8B ZNF189 ZSCAN9 ZNF616 ZNF691	1.27e-07	694	77	15	IPR013087
Domain	Znf_C2H2	TRERF1 ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZSCAN31 ZNF780A ZNF804B ZNF566 ZSCAN26 ZBTB8B ZNF189 ZSCAN9 ZNF616 ZNF691	1.42e-07	805	77	16	IPR007087
Domain	ZnF_C2H2	TRERF1 ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZSCAN31 ZNF780A ZNF804B ZNF566 ZSCAN26 ZBTB8B ZNF189 ZSCAN9 ZNF616 ZNF691	1.50e-07	808	77	16	SM00355
Domain	Hydantoinase/dihydroPyrase	DPYSL2 DPYSL3 DPYSL4	1.34e-06	6	77	3	IPR011778
Domain	-	DPYSL2 DPYSL3 DPYSL4	3.72e-06	8	77	3	2.30.40.10
Domain	zf-C2H2_6	TRERF1 ZNF133 ZNF671 ZNF154 ZSCAN31 ZNF780A ZNF566 ZSCAN9 ZNF616	5.66e-06	314	77	9	PF13912
Domain	Amidohydro_1	DPYSL2 DPYSL3 DPYSL4	7.92e-06	10	77	3	PF01979
Domain	Metal-dep_hydrolase_composite	DPYSL2 DPYSL3 DPYSL4	7.92e-06	10	77	3	IPR011059
Domain	Amidohydro-rel	DPYSL2 DPYSL3 DPYSL4	1.09e-05	11	77	3	IPR006680
Domain	KRAB	ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZNF780A ZNF566 ZNF189 ZNF616	1.62e-05	358	77	9	PS50805
Domain	KRAB	ZNF132 ZNF133 ZSCAN32 ZNF671 ZNF154 ZNF780A ZNF566 ZNF189 ZNF616	2.10e-05	370	77	9	IPR001909
Domain	SCAN	ZSCAN32 ZSCAN31 ZSCAN26 ZSCAN9	8.34e-05	56	77	4	SM00431
Domain	SCAN_BOX	ZSCAN32 ZSCAN31 ZSCAN26 ZSCAN9	9.57e-05	58	77	4	PS50804
Domain	SCAN	ZSCAN32 ZSCAN31 ZSCAN26 ZSCAN9	9.57e-05	58	77	4	PF02023
Domain	SCAN_dom	ZSCAN32 ZSCAN31 ZSCAN26 ZSCAN9	9.57e-05	58	77	4	IPR003309
Domain	Retrov_capsid_C	ZSCAN32 ZSCAN31 ZSCAN26 ZSCAN9	1.02e-04	59	77	4	IPR008916
Domain	KRAB	ZNF132 ZNF133 ZNF671 ZNF154 ZNF780A ZNF566 ZNF189 ZNF616	1.12e-04	358	77	8	PF01352
Domain	Metal_Hydrolase	DPYSL2 DPYSL3 DPYSL4	1.28e-04	24	77	3	IPR032466
Domain	KRAB	ZNF132 ZNF133 ZNF671 ZNF154 ZNF780A ZNF566 ZNF189 ZNF616	1.38e-04	369	77	8	SM00349
Domain	Anaphylatoxin_comp_syst	C4A C4B	1.66e-04	5	77	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	1.66e-04	5	77	2	IPR001840
Domain	ANATO	C4A C4B	3.48e-04	7	77	2	SM00104
Domain	ANATO	C4A C4B	3.48e-04	7	77	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	3.48e-04	7	77	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	3.48e-04	7	77	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	3.48e-04	7	77	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	4.62e-04	8	77	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	4.62e-04	8	77	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	4.62e-04	8	77	2	IPR019742
Domain	LAM_G_DOMAIN	COL24A1 FAT2 CELSR2	5.12e-04	38	77	3	PS50025
Domain	Laminin_G_2	COL24A1 FAT2 CELSR2	5.96e-04	40	77	3	PF02210
Domain	A2M_N	C4A C4B	7.39e-04	10	77	2	PF01835
Domain	A2M_N	C4A C4B	7.39e-04	10	77	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	7.39e-04	10	77	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	7.39e-04	10	77	2	PS00477
Domain	A2M	C4A C4B	7.39e-04	10	77	2	PF00207
Domain	A2M_N_2	C4A C4B	7.39e-04	10	77	2	IPR011625
Domain	A2M_comp	C4A C4B	7.39e-04	10	77	2	IPR011626
Domain	A2M_N_2	C4A C4B	7.39e-04	10	77	2	PF07703
Domain	A2M_recep	C4A C4B	7.39e-04	10	77	2	PF07677
Domain	A2M_comp	C4A C4B	7.39e-04	10	77	2	PF07678
Domain	Macroglobln_a2	C4A C4B	7.39e-04	10	77	2	IPR001599
Domain	Laminin_G	COL24A1 FAT2 CELSR2	1.77e-03	58	77	3	IPR001791
Domain	C345C	C4A C4B	2.19e-03	17	77	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	2.46e-03	18	77	2	IPR008930
Domain	NTR	C4A C4B	2.74e-03	19	77	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	2.74e-03	19	77	2	IPR018933
Domain	NTR	C4A C4B	4.01e-03	23	77	2	PS50189
Domain	Netrin_domain	C4A C4B	4.01e-03	23	77	2	IPR001134
Domain	HormR	VIPR2 CELSR2	4.73e-03	25	77	2	SM00008
Domain	TIMP-like_OB-fold	C4A C4B	5.11e-03	26	77	2	IPR008993
Domain	HRM	VIPR2 CELSR2	5.92e-03	28	77	2	PF02793
Domain	-	COL24A1 FAT2 CELSR2	7.11e-03	95	77	3	2.60.120.200
Pathway	REACTOME_CRMPS_IN_SEMA3A_SIGNALING	DPYSL2 DPYSL3 DPYSL4	2.90e-05	15	58	3	MM15031
Pathway	REACTOME_CRMPS_IN_SEMA3A_SIGNALING	DPYSL2 DPYSL3 DPYSL4	3.56e-05	16	58	3	M8245
Pubmed	Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain.	DPYSL2 DPYSL3 DPYSL4	1.31e-08	3	83	3	11771764
Pubmed	The Ulip family phosphoproteins--common and specific properties.	DPYSL2 DPYSL3 DPYSL4	5.23e-08	4	83	3	9652388
Pubmed	Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system.	DPYSL2 DPYSL3 DPYSL4	5.23e-08	4	83	3	10664068
Pubmed	A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.	DPYSL2 DPYSL3 DPYSL4	1.31e-07	5	83	3	8973361
Pubmed	Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family.	DPYSL2 DPYSL3 DPYSL4	2.61e-07	6	83	3	10956643
Pubmed	CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.	DPYSL2 DPYSL3 DPYSL4	7.28e-07	8	83	3	12134159
Pubmed	Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.	ANKRD44 ANKRD28 ANKRD52	7.28e-07	8	83	3	18186651
Pubmed	Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.	ANKRD44 ANKRD28 ANKRD52	1.09e-06	9	83	3	21187329
Pubmed	Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.	ANKRD44 ANKRD28 ANKRD52	2.84e-06	12	83	3	35512830
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	5.63e-06	2	83	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	5.63e-06	2	83	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	5.63e-06	2	83	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	5.63e-06	2	83	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	5.63e-06	2	83	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	5.63e-06	2	83	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	5.63e-06	2	83	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	5.63e-06	2	83	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	5.63e-06	2	83	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	5.63e-06	2	83	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	5.63e-06	2	83	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	5.63e-06	2	83	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	5.63e-06	2	83	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	5.63e-06	2	83	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	5.63e-06	2	83	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	5.63e-06	2	83	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	5.63e-06	2	83	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	5.63e-06	2	83	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	5.63e-06	2	83	2	20506482
Pubmed	Elevated glucose represses lysosomal and mTOR-related genes in renal epithelial cells composed of progenitor CD133+ cells.	PROM1 MTOR	5.63e-06	2	83	2	33764985
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	5.63e-06	2	83	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	5.63e-06	2	83	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	5.63e-06	2	83	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	5.63e-06	2	83	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	5.63e-06	2	83	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	5.63e-06	2	83	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	5.63e-06	2	83	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	5.63e-06	2	83	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	5.63e-06	2	83	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	5.63e-06	2	83	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	5.63e-06	2	83	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	5.63e-06	2	83	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	5.63e-06	2	83	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	5.63e-06	2	83	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	5.63e-06	2	83	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	5.63e-06	2	83	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	5.63e-06	2	83	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	5.63e-06	2	83	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	5.63e-06	2	83	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	5.63e-06	2	83	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	5.63e-06	2	83	2	3167981
Pubmed	The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis.	MTOR FLCN	5.63e-06	2	83	2	19234517
Pubmed	Mouse pups lacking collapsin response mediator protein 4 manifest impaired olfactory function and hyperactivity in the olfactory bulb.	DPYSL3 DPYSL4	5.63e-06	2	83	2	26118640
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	5.63e-06	2	83	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	5.63e-06	2	83	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	5.63e-06	2	83	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	5.63e-06	2	83	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	5.63e-06	2	83	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	5.63e-06	2	83	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	5.63e-06	2	83	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	5.63e-06	2	83	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	5.63e-06	2	83	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	5.63e-06	2	83	2	29080553
Pubmed	Functional variants in DPYSL2 sequence increase risk of schizophrenia and suggest a link to mTOR signaling.	DPYSL2 MTOR	5.63e-06	2	83	2	25416705
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	5.63e-06	2	83	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	5.63e-06	2	83	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	5.63e-06	2	83	2	25339671
Pubmed	TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt-mTOR pathway.	MTOR TTK	5.63e-06	2	83	2	32530571
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	5.63e-06	2	83	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	5.63e-06	2	83	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	5.63e-06	2	83	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	5.63e-06	2	83	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	5.63e-06	2	83	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	5.63e-06	2	83	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	5.63e-06	2	83	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	5.63e-06	2	83	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	5.63e-06	2	83	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	5.63e-06	2	83	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	5.63e-06	2	83	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	5.63e-06	2	83	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	5.63e-06	2	83	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	5.63e-06	2	83	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	5.63e-06	2	83	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	5.63e-06	2	83	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	5.63e-06	2	83	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	5.63e-06	2	83	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	5.63e-06	2	83	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	5.63e-06	2	83	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	5.63e-06	2	83	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	5.63e-06	2	83	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	5.63e-06	2	83	2	17971229
Pubmed	Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression.	MTOR FLCN	5.63e-06	2	83	2	26418749
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	5.63e-06	2	83	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	5.63e-06	2	83	2	3944109
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	5.63e-06	2	83	2	17921792
Pubmed	DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders.	DPYSL2 MTOR	5.63e-06	2	83	2	37479784
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	5.63e-06	2	83	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	5.63e-06	2	83	2	6978711
Pubmed	Ciliary localization of folliculin mediated via a kinesin-2-binding motif is required for its functions in mTOR regulation and tumor suppression.	MTOR FLCN	5.63e-06	2	83	2	33064845
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	5.63e-06	2	83	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	5.63e-06	2	83	2	33353966
Interaction	DPYS interactions	DPYSL2 DPYSL3 DPYSL4	1.34e-05	12	81	3	int:DPYS
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF132 ZNF133 ZSCAN32 ZNF671 ZSCAN12 ZNF154 ZSCAN31 ZNF780A ZNF566 ZSCAN26 ZBTB8B ZNF189 ZSCAN9 ZNF616 ZNF691	1.72e-08	718	63	15	28
GeneFamily	Protein phosphatase 6 regulatory subunits	ANKRD44 ANKRD28 ANKRD52	8.00e-07	6	63	3	699
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	4.23e-04	9	63	2	1234
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DPYSL3 FAT2 NET1 ABCA13 SERPINB1 CTNND1 FAM83B	8.69e-08	197	83	7	233b9fcb376e08d0080a05ca0198ecc6ec720f90
ToppCell	Biopsy_IPF-Mesenchymal-Mesothelial_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	TBX18 VIPR2 SLITRK2 PROCR PTPRQ C4A C4B	9.63e-08	200	83	7	553386523fd8f8f36617a0d81032224b7ddce442
ToppCell	Control-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	TBX18 VIPR2 SLITRK2 C4A C4B ITLN2	6.88e-07	166	83	6	32ebaefa6c074b28193fff764ee7c2c0e9357e20
ToppCell	3'_v3-lymph-node_spleen-Mast-Mast_cell_lympho\|lymph-node_spleen / Manually curated celltypes from each tissue	ZSCAN12 PROCR BIVM ANKRD28 DNAAF9 ZNF691	1.00e-06	177	83	6	53040dbeb18574a48e352e4bce252c7c3018762c
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRERF1 SLITRK2 CELSR2 MTOR SOSTDC1 DPYSL4	1.10e-06	180	83	6	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRERF1 SLITRK2 CELSR2 MTOR SOSTDC1 DPYSL4	1.10e-06	180	83	6	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRERF1 SLITRK2 CELSR2 MTOR SOSTDC1 DPYSL4	1.10e-06	180	83	6	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 SLITRK2 ABCA13 PTPRQ PKD1L2 MYO15A	1.25e-06	184	83	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 SLITRK2 ABCA13 PTPRQ PKD1L2 MYO15A	1.25e-06	184	83	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 SLITRK2 ABCA13 PTPRQ PKD1L2 MYO15A	1.25e-06	184	83	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Control-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	TBX18 VIPR2 DPYSL3 NHSL2 PROCR C4A	1.29e-06	185	83	6	0af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TBX18 VIPR2 PROCR PTPRQ C4A C4B	1.33e-06	186	83	6	7812ed80d2378aca9957ef22fc3c8fb7fb58434b
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBX18 VIPR2 PROCR PTPRQ C4A ROBO3	1.70e-06	194	83	6	79baee8b35b7707bbeb07c73b5e17b68bcd7bbc2
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBX18 VIPR2 PROCR PTPRQ C4A ROBO3	1.70e-06	194	83	6	f6e348f1f35c526cad6c349f1fdd0bd92d18aa3c
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBX18 VIPR2 PROCR PTPRQ C4A ROBO3	1.70e-06	194	83	6	ce599ed0dc181aea0584e426636de5098f34ebe6
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX18 VIPR2 SLITRK2 PROCR PTPRQ ROBO3	1.76e-06	195	83	6	a52685f76eca269a7d2de8dfc317439483e233fa
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX18 VIPR2 SLITRK2 PROCR PTPRQ ROBO3	1.76e-06	195	83	6	224deeba2f60def6543a55bb4f5ee6c7fdab3f02
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TBX18 VIPR2 SLITRK2 PTPRQ C4A C4B	1.86e-06	197	83	6	88a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TBX18 VIPR2 SLITRK2 PTPRQ C4A C4B	1.86e-06	197	83	6	2773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCell	Biopsy_Other_PF-Mesenchymal-Mesothelial_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	VIPR2 SLITRK2 PTPRQ C4A C4B ITLN2	1.92e-06	198	83	6	86736f01e61bf4961f060b24ee1f1f48340737dd
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Mesothelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	TBX18 VIPR2 PROCR PTPRQ C4A C4B	1.97e-06	199	83	6	ca970114b5aef4518ce580897a62ac88688b2671
ToppCell	CV-Mild-3\|Mild / Virus stimulation, Condition and Cluster	PKMYT1 ZNF132 ZNF133 BIVM MOCS1	1.48e-05	166	83	5	5599f90fc0e15a3670b03187085eba91228390a2
ToppCell	Control-Epithelial-Mesothelial\|Control / Disease state, Lineage and Cell class	TBX18 VIPR2 SLITRK2 C4A C4B	1.48e-05	166	83	5	1ed3788257e14f097862b999f020bfe2a57de52b
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF671 ZNF189 DPYSL4 ZNF616 SLC9A6	1.81e-05	173	83	5	090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF671 ZNF189 DPYSL4 ZNF616 SLC9A6	1.86e-05	174	83	5	a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell	ASK452-Immune-B_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	VIPR2 COL24A1 ZSCAN12 DNAJB9 ANKRD52	1.86e-05	174	83	5	69723f5666abc3af5f0431901a60246c9915ef81
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TBX18 VIPR2 SLITRK2 C4A C4B	2.02e-05	177	83	5	0912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBX18 ZNF804B PTPRQ SERPINB1 C4B	2.13e-05	179	83	5	adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCell	IPF-Epithelial-Mesothelial\|IPF / Disease state, Lineage and Cell class	TBX18 VIPR2 PTPRQ C4A C4B	2.19e-05	180	83	5	1fa54bf4dba72866b2295639d991af639341bc08
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PROM1 ZNF804B SLC25A48 FAM83B CCSER1	2.31e-05	182	83	5	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	IPF-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	VIPR2 DPYSL3 PTPRQ C4A C4B	2.37e-05	183	83	5	7df20e3172a1220ff427f30181f4f0c3b7fe2d42
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRERF1 PROM1 VIPR2 COL24A1 SOSTDC1	2.37e-05	183	83	5	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	wk_20-22-Mesenchymal-Mesothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TBX18 VIPR2 PTPRQ C4A ITLN2	2.43e-05	184	83	5	804f8a41cd6b1361448872bf352bf0a38a0fac66
ToppCell	wk_20-22-Mesenchymal-Mesothelial-Late_mesothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TBX18 VIPR2 PTPRQ C4A ITLN2	2.43e-05	184	83	5	60dd055c2e2e92b838ac649c12e8cccd9c3b1b71
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRERF1 PROM1 VIPR2 COL24A1 SOSTDC1	2.49e-05	185	83	5	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	wk_15-18-Mesenchymal-Mesothelial-Late_mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TBX18 VIPR2 PTPRQ C4A ITLN2	2.69e-05	188	83	5	38a53f99f1876359983936403aefca93281d10fd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TBX18 VIPR2 DPYSL3 HMCN2 PROCR	2.69e-05	188	83	5	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	COPD-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	DPYSL3 NHSL2 PROCR C4A C4B	2.69e-05	188	83	5	159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCell	COVID_vent-Myeloid-Monocytic-SC_&_Eosinophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	SLC2A10 PROM1 COL24A1 DPYSL3 ANKRD28	2.76e-05	189	83	5	2157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TBX18 VIPR2 DPYSL3 HMCN2 PROCR	2.83e-05	190	83	5	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBX18 VIPR2 PROCR ITLN2 ROBO3	2.90e-05	191	83	5	b7713aba839e7a1f548b7b9d8893067bcc6d7ee7
ToppCell	wk_08-11-Mesenchymal-Mesothelial-intermediate_mesothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TBX18 PROCR PTPRQ C4A ITLN2	2.98e-05	192	83	5	ac9e5288ecd4b1e142f2e15a1fcd11c8eb9e15cd
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBX18 VIPR2 PROCR PTPRQ C4A	3.13e-05	194	83	5	421344cc4b601d9745fa72d0af3124dab11d1d27
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKMYT1 FAT2 NET1 CTNND1 TTK	3.37e-05	197	83	5	1d4ccca2ff46fccb3ac052b5148cb7f94231d65a
ToppCell	Bronchial-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TBX18 VIPR2 SLITRK2 PTPRQ C4B	3.37e-05	197	83	5	26888af95a7cc082a1f1218af35b1f07cb9436ed
ToppCell	Bronchial-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TBX18 VIPR2 SLITRK2 PTPRQ C4B	3.37e-05	197	83	5	438de7f0d35d81d5f5e41dcef7b2c54b6da03df4
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FAT2 NET1 ABCA13 ACOT11 CTNND1	3.62e-05	200	83	5	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	TBX18 VIPR2 PROCR PTPRQ ITLN2	3.62e-05	200	83	5	c800f20adedf4ca736c740510889e92d8bf0ba44
ToppCell	Parenchyma_COVID-19-Stromal-TX-Mesothelial-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	TBX18 VIPR2 PROCR PTPRQ ITLN2	3.62e-05	200	83	5	bf50e30d5cafb71c567e89580f62084d2f894170
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBX18 VIPR2 PROCR PTPRQ ITLN2	3.62e-05	200	83	5	5e5ad07679d5dd2ca80249bce9aaf4a95d42187b
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT2 NET1 ABCA13 ACOT11 CTNND1	3.62e-05	200	83	5	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX18 COL24A1 DPYSL3 SOSTDC1 SLC25A48	3.62e-05	200	83	5	fb53be20392a8309a7393774c774a1b1aec6e676
ToppCell	TCGA-Mesothelium\|World / Sample_Type by Project: Shred V9	TBX18 PROCR PTPRQ ITLN2	1.02e-04	130	83	4	3ef1733eb57e2a9a3298ce0d65401f19e2084df1
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-B_lymphocytic-naive_B_cell\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ANKRD44 ZNF154 DIDO1 ITPR1	1.06e-04	131	83	4	d76a7a9b50ee6d24b74494c6f6b88b3506b3f9ad
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 CELSR2 PTPRQ MYO15A	1.40e-04	141	83	4	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 CELSR2 PTPRQ MYO15A	1.40e-04	141	83	4	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCell	facs-Heart-Unknown-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 CELSR2 PTPRQ MYO15A	1.44e-04	142	83	4	759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Migrating_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	COL24A1 ZSCAN12 NET1 ROBO3	2.02e-04	155	83	4	1882fa5fd25f77d6e3ac47b613f6fb3c67d8e50c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZSCAN12 ZNF154 PGLYRP2 TTK	2.17e-04	158	83	4	d72d6527dc50207ddbada262460d3c4bac249a19
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PHAF1 TNFSF9 BIVM ZNF566	2.22e-04	159	83	4	1472536eea61d4f13033efe42f128bae1614fa74
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	PHAF1 TNFSF9 BIVM ZNF566	2.22e-04	159	83	4	2fb1d2ff52920aeb48d048cf29f0cd45f944a73d
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	TBX18 SLITRK2 NHSL2 ROBO3	2.22e-04	159	83	4	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	VIPR2 TNFSF9 ZSCAN9 SLC25A48	2.22e-04	159	83	4	57df5c9b678a15eb5e025e1a80de2e6769cc13d5
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|356C / Donor, Lineage, Cell class and subclass (all cells)	ZNF671 ZNF189 DPYSL4 ZNF616	2.50e-04	164	83	4	d5bb57c321f2973836efc8990449494cc1fb87c7
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKMYT1 PROM1 ABCA13 SERPINB1	2.50e-04	164	83	4	2a230ea066decb798a0e6f2b96c7608c8e608031
ToppCell	Multiple_Sclerosis-Other-HSPC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	PROM1 DPYSL3 SOSTDC1 ANKRD28	2.50e-04	164	83	4	6af5529507d695b347adee4be5ead70f56c9cf55
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKMYT1 PROM1 ABCA13 SERPINB1	2.50e-04	164	83	4	d02d39edd0bfef5a53b814ec6d5f026d41253218
ToppCell	COVID-19-lung-Mesothelial\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TBX18 VIPR2 PTPRQ ITLN2	2.50e-04	164	83	4	83303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCell	10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-MPP_myeloid\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PROM1 ACOT11 PGLYRP2 ROBO3	2.56e-04	165	83	4	dc70e050465d1f05bb4115356dc978aa581149b5
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	TBX18 VIPR2 PTPRQ ITLN2	2.62e-04	166	83	4	4d63c758d46e73311b864148c646bf081498dee7
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|368C / Donor, Lineage, Cell class and subclass (all cells)	TBX18 VIPR2 PTPRQ ITLN2	2.62e-04	166	83	4	4160ccf9291072a6e2782f9ad141bc9a9747f3ad
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	TBX18 DPYSL3 HMCN2 ROBO3	2.68e-04	167	83	4	c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DPYSL3 FAT2 ABCA13 CCSER1	2.74e-04	168	83	4	6521bead9789d626b86cbd08692c621c5a5aef33
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tnaive/CM_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ZSCAN32 NHSL2 PROCR BIVM	2.74e-04	168	83	4	c51244b4bdbfd961e2725306aa9cb25dd66d58bd
ToppCell	facs-Tongue-nan-24m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYSL2 SLITRK2 SERPINB1 C4B	2.80e-04	169	83	4	0054f9bfd4d377c7fd94873c1308622051c59a8e
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DPYSL3 FAT2 ABCA13 CCSER1	2.80e-04	169	83	4	c3ee781735a9288ce1822b230d39bb91c1415589
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 ABCA13 C4B KCNH4	2.80e-04	169	83	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-NK-NK-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KIR3DX1 TIE1 ANXA11 TMEM200A	2.87e-04	170	83	4	aaf29c2d4de172d366cbfc863bc741941667dde1
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FAT2 KIR3DX1 PROCR SOSTDC1	2.87e-04	170	83	4	81341bf4fe090af70b2091b6b2579ed08d76e22d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLITRK2 BIVM MRPS5 ZNF616	2.87e-04	170	83	4	09bcbc7eb3b1d35cf03f01ce2f2fe37373382dd4
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PROM1 NHSL2 ABCA13 TTK	2.93e-04	171	83	4	913bae728b5e653771a27c79a309eb023699f1d0
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	FAT2 ABCA13 PTPRQ FAM83B	2.93e-04	171	83	4	3965ced4be6db14265a90673502fceee425837ca
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PROM1 NHSL2 ABCA13 TTK	2.93e-04	171	83	4	f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCell	Healthy/Control-NK_CD56bright\|World / Disease group and Cell class	SLC2A10 ZNF154 TIE1 TNFSF9	2.93e-04	171	83	4	79d7efefdae267905af05f3001514b8b6934d86e
ToppCell	356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ANKRD28 PGLYRP2 CSMD2 TMEM200A	2.93e-04	171	83	4	bdd30100b74e012eec3090799c22635aa57fa91d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PKMYT1 ZNF132 ZNF616 KCNH4	3.06e-04	173	83	4	9f892d756d05e573af018db64edb130ff187ad47
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-HSC/MPP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PROM1 ACOT11 PROCR ANKRD28	3.06e-04	173	83	4	34357f0e22c4b6d84582492c82c1ea733ca8477d
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR2 SOSTDC1 SERPINB1 PKD1L2	3.13e-04	174	83	4	165e14cad57e90aa247dcecfaa3c2e8ff2a470ad
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR2 SOSTDC1 SERPINB1 PKD1L2	3.13e-04	174	83	4	4289dfc7613db4bb3d706b9b65d06e84c0c53558
ToppCell	Healthy_Control-Myeloid-Mast\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	PROM1 TIE1 ACOT11 CCSER1	3.20e-04	175	83	4	ca187074adcc9b8bd0fa270e2ede1564c8e6c6cf
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	TRERF1 FAT2 CTNND1 FAM83B	3.20e-04	175	83	4	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	Healthy_Control-Myeloid-Mast-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	PROM1 TIE1 ACOT11 CCSER1	3.20e-04	175	83	4	eadbbcdf2aef4cee268bc70a7a2c4175d898953b
ToppCell	facs-Tongue-nan-24m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYSL2 SLITRK2 SOSTDC1 C4B	3.20e-04	175	83	4	758a1796b823118ce52f989ef5e1076f8c8ac4c5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VIPR2 DPYSL3 TIE1 ZNF804B	3.20e-04	175	83	4	d4827b4dfad07f11cbdd47fbed287af1afb9b1b8
ToppCell	droplet-Liver-LIVER-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKMYT1 DPYSL3 ZNF566 TTK	3.27e-04	176	83	4	4d2fb51e71bed0d72f3d7f89d395744860885a5f
ToppCell	droplet-Liver-LIVER-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKMYT1 DPYSL3 ZNF566 TTK	3.27e-04	176	83	4	4880fa20b50eb10358e08567e08559ef2954f237
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHSL2 ZNF804B PTPRQ TMEM200A	3.27e-04	176	83	4	03d194c9814e12802cd932afade69e868814cb78
ToppCell	droplet-Liver-LIVER-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKMYT1 DPYSL3 ZNF566 TTK	3.27e-04	176	83	4	fcdddd949ca05b3ecde240db9e38296a6eab2d6a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VIPR2 ZNF804B CTNND1 TMEM200A	3.34e-04	177	83	4	f902600c639087664316b3cf30cab243bc3d1c5c
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PROM1 NHSL2 ABCA13 SERPINB1	3.34e-04	177	83	4	b41e975e8368e2618b015be095efe8c0e001c78b
Disease	anxiety, stress-related disorder, major depressive disorder	ZSCAN12 ZSCAN31 ZSCAN26 ZSCAN9	7.88e-06	46	81	4	EFO_0005230, EFO_0010098, MONDO_0002009
Disease	coronary aneurysm	COL24A1 CSMD2 SLC25A48	1.22e-04	35	81	3	EFO_1000881
Disease	retinal vasculature measurement	VIPR2 PROCR ZNF804B OSBPL8 MOCS1 ITPR1 CCSER1	5.53e-04	517	81	7	EFO_0010554
Disease	renal cell carcinoma (is_implicated_in)	FLCN C4A C4B	9.16e-04	69	81	3	DOID:4450 (is_implicated_in)
Disease	sphingosine 1-phosphate measurement	OMA1 ITPR1	1.11e-03	18	81	2	EFO_0800185
Disease	depressive symptom measurement, response to antidepressant	ANKRD44 BIVM CCSER1	1.85e-03	88	81	3	EFO_0007006, GO_0036276

Protein segments in the cluster

Peptide	Gene	Start	Entry
RTQSGLQSYLLQFHG	PROCR	81	Q9UNN8
SGHFQRLLISLSQGN	ANXA11	331	P50995
LHFTSDGNHRQRGFS	CSMD2	286	Q7Z408
GNNNSARLLGVFSHS	CSMD2	1156	Q7Z408
NIQGINLLFSSRRGH	C4B	126	P0C0L5
RNLHQSGFSLSGTQV	DPYSL3	531	Q14195
HGRFSRSQTIIQSGA	ANKRD28	316	O15084
SFSQGHLQNILGNFR	ABCA13	1411	Q86UQ4
GNHLRRGLASVFSNR	ACOT11	6	Q8WXI4
QHGRLGRSFSASFHQ	BIVM	461	Q86UB2
ATARQHSTFTGRFGQ	CCSER1	851	Q9C0I3
SNQHGIRRNLTAALG	CELSR2	2406	Q9HCU4
HGRFTRSQILIQNGS	ANKRD52	316	Q8NB46
RFENHFQTRQDGGSS	DNAJB9	136	Q9UBS3
FGQTIQSFTLRGDHR	NET1	116	Q7Z628
FTPFLHQRNGNAARS	FLCN	226	Q8NFG4
VSGALQLLFRHFSQR	ITPR1	1086	Q14643
SLRNRQGQHFCAGSL	MST1L	501	Q2TV78
NLQRALSAFGAHRGL	MYO15A	541	Q9UKN7
VRNLHQSGFSLSGAQ	DPYSL2	531	Q16555
GVSRRRHNSSDGFFN	GPBP1L1	41	Q9HC44
RFTLSFGHRQNSTGI	SLC2A10	516	O95528
LNGHSLTGGRFRQES	HMCN2	4466	Q8NDA2
SFNGTDNHIRFLQQR	FAM83B	466	Q5T0W9
LHGFNLSLQARSGSG	FAT2	326	Q9NYQ8
GNQDRHFFINSSSGI	FAT2	2421	Q9NYQ8
NLGLTFLRGSQTQSH	PGLYRP2	226	Q96PD5
SRRLSFQRDFSGQHN	HRNR	156	Q86YZ3
HSNFLLANAQGTRGF	KCNH4	26	Q9UQ05
HGRFTRSQTLIQNGG	ANKRD44	316	Q8N8A2
LSGGQRHREAFQANF	KIR3DX1	266	Q9H7L2
AQQRLGSGSFQRHYT	MOCS1	436	Q9NZB8
LNRHLQHSFTRGFSG	PKD1L2	1976	Q7Z442
RFGHGNQVSSLLSVR	PTPRQ	781	Q9UMZ3
GGFLNAIAHTANTFR	OR9G4	166	Q8NGQ1
GLLRANNLHSGDNFQ	OSBPL8	296	Q9BZF1
VRNLHQSGFSLSGSQ	DPYSL4	531	O14531
FGNHSTRENLNAGNF	DNAAF9	291	Q5TEA3
SSRGRFGVVANNNRH	DIDO1	1141	Q9BTC0
ISHNAAFGTGRAARN	DEGS2	91	Q6QHC5
YRTNTGFLQRLGHNL	ITLN2	181	Q8WWU7
TIHFNQRGTRLASSG	DCAF8L1	201	A6NGE4
FIRHNSSGSILFLGR	SERPINB1	361	P30740
ANGTLTRRHQNGRFV	CTNND1	56	O60716
NIQGINLLFSSRRGH	C4A	126	P0C0L4
QGFFRSISLSRGNNL	MTOR	1886	P42345
TQGLFRGLSRQETHQ	MRPS5	346	P82675
LNLGRRSKIGSNFQH	SLC9A6	436	Q92581
SFGHFIARLQGSILQ	SMG5	771	Q9UPR3
GAARRQFGSNTSLHL	TMEM200A	376	Q86VY9
IIGFSNFSQRDQGHS	NHSL2	286	Q5HYW2
NRGTYGTLHLQNSFN	PROM1	566	O43490
FGGTALTRLNLRNNH	SLITRK2	491	Q9H156
GSTAQQFLTFLSHRG	INPPL1	846	O15357
VFGVFSNTQRFLSQH	SLC25A48	76	Q6ZT89
NSAEQLFHLNFRGLS	PHAF1	121	Q9BSU1
GLQSAARNHVFFRFN	OMA1	6	Q96E52
GLQSHRVNNAFLFSI	COL24A1	111	Q17RW2
GRAFSQSSNFLRHQK	ZNF132	381	P52740
GKAFSRNSGLIQHQR	ZNF189	546	O75820
GRRDFSATSGLLQHQ	ZNF671	246	Q8TAW3
CSSHRFNGNSRGNLL	ZNF804B	726	A4D1E1
HLRGNNFSGQEASRQ	ZSCAN31	26	Q96LW9
GKAFNQGSTLNRHQR	ZNF616	611	Q08AN1
GRTFSDISNFGAHQR	ZNF691	261	Q5VV52
GKRFNNSSQFSAHRR	ZSCAN32	611	Q9NX65
FQQSFQRLSRLGHGS	PKMYT1	106	Q99640
FNAALTALGAGQHRT	RHBG	236	Q9H310
HLLSSGGQQSFFDSR	TBX18	576	O95935
ARNGSHQVTLRGFSK	TIE1	81	P35590
LGNESRFHLNRSAAG	ROBO3	811	Q96MS0
KFFRRGSNLNQHRSI	ZNF780A	536	O75290
SNSTLNQARNGGRHF	SOSTDC1	46	Q6X4U4
NQARNGGRHFSNTGL	SOSTDC1	51	Q6X4U4
EARNSAFGFQGRLLH	TNFSF9	191	P41273
EGALQFHRGSRAQSF	VIPR2	416	P41587
CGRGFSQQSNLIRHQ	ZNF133	471	P52736
GEAFRQRSGLFQHQR	ZSCAN26	456	Q16670
AQESFSGSLGHLQNR	TTK	211	P33981
GKAFSSGSNFTRHQR	ZNF566	261	Q969W8
GKSFSQRSALLQHRG	ZNF154	251	Q13106
FSRSSGLFNHRGIHN	ZSCAN9	291	O15535
RVNRSQSFAGVLGSH	RIPOR1	16	Q6ZS17
GNAFRGITSLIQHQR	ZSCAN12	531	O43309
GAVFSSRQALNGHAR	TRERF1	1021	Q96PN7
TFTSHLSQGLRRFGL	ZBTB8B	406	Q8NAP8