Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine kinase activity	RIOK1 MAST4 MTOR MAST1 MAPK8 MAP3K1 MAST3	1.74e-04	363	65	7	GO:0106310
GeneOntologyMolecularFunction	methylated histone binding	PHF2 ZMYND8 ING5 ING4	1.78e-04	86	65	4	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	PHF2 ZMYND8 ING5 ING4	1.94e-04	88	65	4	GO:0140034
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	RIOK1 MAST4 MTOR MAST1 MAPK8 MAP3K1 MAST3	6.03e-04	446	65	7	GO:0004674
GeneOntologyMolecularFunction	protein kinase activity	BLK RIOK1 MAST4 MTOR MAST1 MAPK8 MAP3K1 MAST3	7.09e-04	600	65	8	GO:0004672
GeneOntologyMolecularFunction	magnesium ion binding	MAST4 MAT1A MAST1 IDH1 MAST3	1.26e-03	247	65	5	GO:0000287
GeneOntologyMolecularFunction	myosin heavy chain binding	NKD2 MYBPC3	1.37e-03	17	65	2	GO:0032036
Domain	DUF1908	MAST4 MAST1 MAST3	1.39e-07	4	62	3	PF08926
Domain	MA_Ser/Thr_Kinase_dom	MAST4 MAST1 MAST3	1.39e-07	4	62	3	IPR015022
Domain	MAST_pre-PK_dom	MAST4 MAST1 MAST3	1.39e-07	4	62	3	IPR023142
Domain	-	MAST4 MAST1 MAST3	1.39e-07	4	62	3	1.20.1480.20
Domain	GPCR_2_brain_angio_inhib	ADGRB1 ADGRB3	3.25e-05	3	62	2	IPR008077
Domain	Zinc_finger_PHD-type_CS	PHF2 ZMYND8 ING5 ING4	6.40e-05	65	62	4	IPR019786
Domain	ING	ING5 ING4	1.08e-04	5	62	2	SM01408
Domain	ING_N_histone_binding	ING5 ING4	1.08e-04	5	62	2	IPR024610
Domain	ING	ING5 ING4	1.08e-04	5	62	2	PF12998
Domain	ING_fam	ING5 ING4	1.08e-04	5	62	2	IPR028651
Domain	PHD	PHF2 ZMYND8 ING5 ING4	1.12e-04	75	62	4	PF00628
Domain	-	PHF2 TRIM49 RNF148 ZMYND8 TRIM49C ING5 ING4 MAP3K1	1.14e-04	449	62	8	3.30.40.10
Domain	ARM-type_fold	SF3B1 UPF2 INTS7 MTOR MROH2A RALGAPA2 MAP3K1	1.27e-04	339	62	7	IPR016024
Domain	Znf_RING/FYVE/PHD	PHF2 TRIM49 RNF148 ZMYND8 TRIM49C ING5 ING4 MAP3K1	1.32e-04	459	62	8	IPR013083
Domain	Znf_PHD-finger	PHF2 ZMYND8 ING5 ING4	1.37e-04	79	62	4	IPR019787
Domain	PHD	PHF2 ZMYND8 ING5 ING4	2.18e-04	89	62	4	SM00249
Domain	Znf_PHD	PHF2 ZMYND8 ING5 ING4	2.37e-04	91	62	4	IPR001965
Domain	ZF_PHD_2	PHF2 ZMYND8 ING5 ING4	2.80e-04	95	62	4	PS50016
Domain	ZF_PHD_1	PHF2 ZMYND8 ING5 ING4	2.91e-04	96	62	4	PS01359
Domain	Kinase-like_dom	BLK RIOK1 MAST4 MTOR MAST1 MAPK8 MAP3K1 MAST3	4.07e-04	542	62	8	IPR011009
Domain	Keratin_I	KRT13 KRT15 KRT37	4.19e-04	44	62	3	IPR002957
Domain	GAIN_dom_N	ADGRB1 ADGRB3	5.85e-04	11	62	2	IPR032471
Domain	GAIN	ADGRB1 ADGRB3	5.85e-04	11	62	2	PF16489
Domain	AGC-kinase_C	MAST4 MAST1 MAST3	8.52e-04	56	62	3	IPR000961
Domain	AGC_KINASE_CTER	MAST4 MAST1 MAST3	8.52e-04	56	62	3	PS51285
Domain	S_TK_X	MAST4 MAST1 MAST3	8.52e-04	56	62	3	SM00133
Domain	Prot_kinase_dom	BLK RIOK1 MAST4 MAST1 MAPK8 MAP3K1 MAST3	1.15e-03	489	62	7	IPR000719
Domain	Intermediate_filament_CS	KRT13 KRT15 KRT37	1.20e-03	63	62	3	IPR018039
Domain	PROTEIN_KINASE_DOM	BLK RIOK1 MAST4 MAST1 MAPK8 MAP3K1 MAST3	1.20e-03	493	62	7	PS50011
Domain	PDZ	MAST4 STXBP4 MAST1 MAST3	1.24e-03	141	62	4	PF00595
Domain	Znf_FYVE_PHD	PHF2 ZMYND8 ING5 ING4	1.44e-03	147	62	4	IPR011011
Domain	PDZ	MAST4 STXBP4 MAST1 MAST3	1.48e-03	148	62	4	SM00228
Domain	-	MAST4 STXBP4 MAST1 MAST3	1.55e-03	150	62	4	2.30.42.10
Domain	PDZ	MAST4 STXBP4 MAST1 MAST3	1.59e-03	151	62	4	PS50106
Domain	HEAT_REPEAT	SF3B1 MTOR MROH2A	1.63e-03	70	62	3	PS50077
Domain	PDZ	MAST4 STXBP4 MAST1 MAST3	1.63e-03	152	62	4	IPR001478
Domain	Filament	KRT13 KRT15 KRT37	1.70e-03	71	62	3	SM01391
Domain	IF	KRT13 KRT15 KRT37	1.77e-03	72	62	3	PS00226
Domain	Filament	KRT13 KRT15 KRT37	1.84e-03	73	62	3	PF00038
Domain	IF	KRT13 KRT15 KRT37	2.06e-03	76	62	3	IPR001664
Domain	HormR	ADGRB1 ADGRB3	3.10e-03	25	62	2	SM00008
Domain	HRM	ADGRB1 ADGRB3	3.88e-03	28	62	2	PF02793
Domain	PROTEIN_KINASE_ATP	BLK MAST4 MAST1 MAPK8 MAP3K1 MAST3	4.10e-03	459	62	6	PS00107
Domain	GPS	ADGRB1 ADGRB3	5.68e-03	34	62	2	SM00303
Domain	GPS	ADGRB1 ADGRB3	6.01e-03	35	62	2	PF01825
Domain	GPS	ADGRB1 ADGRB3	6.35e-03	36	62	2	PS50221
Domain	Ser/Thr_kinase_AS	MAST4 MAST1 MAPK8 MAP3K1 MAST3	6.59e-03	357	62	5	IPR008271
Pubmed	Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.	CLPP KRT13 SF3B1 ZMYND8 USP7 MCM7	7.27e-08	113	65	6	23403292
Pubmed	FAM188B enhances cell survival via interaction with USP7.	KRT13 KRT15 SF3B1 USP7 EIF3H	1.48e-07	65	65	5	29795372
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	TPR WASHC4 MTOR ADGRB1 PSME1 EIF3H MYBPC3	1.64e-06	304	65	7	32235678
Pubmed	The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.	MAPK8 MAP3K1	3.44e-06	2	65	2	12122119
Pubmed	Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion.	MTOR MAPK8	3.44e-06	2	65	2	25254627
Pubmed	USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion.	ZMYND8 USP7	3.44e-06	2	65	2	39128723
Pubmed	Protein tyrosine phosphatase nonreceptor type 12 suppresses the proliferation of renal cell carcinoma by inhibiting the activity of the PI3K/mTOR pathway.	PTPN12 MTOR	3.44e-06	2	65	2	26537073
Pubmed	IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation.	IDH1 MAPK8	3.44e-06	2	65	2	28402860
Pubmed	CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).	TPR SF3B1 USP7 MCM7	3.53e-06	55	65	4	23178491
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	TPR SF3B1 MYO5A FAM186A LAMA1 USP7	5.16e-06	234	65	6	36243803
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	SF3B1 UPF2 MTOR MCM7 PSME1 IDH1 EIF3H GNAT1	7.25e-06	538	65	8	28524877
Pubmed	MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver.	MAPK8 MAP3K1	1.03e-05	3	65	2	16081685
Pubmed	Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival.	MTOR IDH1	1.03e-05	3	65	2	29328863
Pubmed	Arrangement of a cluster of three mouse type I keratin genes expressed sequentially during esophageal-type epithelial cell differentiation.	KRT13 KRT15	1.03e-05	3	65	2	7535287
Pubmed	Dominant negative MEKK1 inhibits survival of pancreatic cancer cells.	MAPK8 MAP3K1	1.03e-05	3	65	2	12185592
Pubmed	PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation.	MTOR MFN2	1.03e-05	3	65	2	30887444
Pubmed	Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.	MTOR MAPK8	1.03e-05	3	65	2	16099428
Pubmed	EBNA3C attenuates the function of p53 through interaction with inhibitor of growth family proteins 4 and 5.	ING5 ING4	1.03e-05	3	65	2	21177815
Pubmed	Loss of MAP3K1 enhances proliferation and apoptosis during retinal development.	MAPK8 MAP3K1	1.03e-05	3	65	2	21862560
Pubmed	Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor.	MAPK8 MAP3K1	1.03e-05	3	65	2	16491099
Pubmed	FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.	MAPK8 MAP3K1	1.03e-05	3	65	2	17409352
Pubmed	Altered myocardial gene expression reveals possible maladaptive processes in heterozygous and homozygous cardiac myosin-binding protein C knockout mice.	MAPK8 MYBPC3	1.03e-05	3	65	2	18060737
Pubmed	MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway.	MTOR MCM7	1.03e-05	3	65	2	28498460
Pubmed	Induced proliferation of human MRC-5 cells by nitrogen oxides via direct and indirect activation of MEKK1, JNK, and p38 signals.	MAPK8 MAP3K1	1.03e-05	3	65	2	12079429
Pubmed	Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).	ADGRB1 ADGRB3	1.03e-05	3	65	2	9533023
Pubmed	Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.	ADGRB1 ADGRB3	1.03e-05	3	65	2	15225653
Pubmed	MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts.	MAPK8 MAP3K1	1.03e-05	3	65	2	29499695
Pubmed	MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases.	MAPK8 MAP3K1	1.03e-05	3	65	2	9405400
Pubmed	Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2.	MAPK8 MAP3K1	1.03e-05	3	65	2	18032450
Pubmed	Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma.	TPR MTOR	1.03e-05	3	65	2	32207633
Pubmed	Dilute suppressor, a new suppressor gene in the house mouse.	MYO5A IDH1	1.03e-05	3	65	2	6886377
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT13 PTPN12 KRT15 AGO1 PSME1 KRT37	1.07e-05	266	65	6	19380743
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	CLPP BRD8 AGO1 MYO5A MTOR STXBP4 ZMYND8 ADGRB1 CC2D2A EIF3H MAP3K1	1.76e-05	1242	65	11	30973865
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	TPR KRT13 KRT15 SF3B1 UPF2 MYO5A USP7 MCM7 EIF3H FLOT1 NGDN	1.96e-05	1257	65	11	36526897
Pubmed	Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells.	MAPK8 MAP3K1	2.06e-05	4	65	2	14612408
Pubmed	Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production.	MAPK8 MAP3K1	2.06e-05	4	65	2	17143273
Pubmed	Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.	MTOR MYBPC3	2.06e-05	4	65	2	24371138
Pubmed	Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation.	MAPK8 MAP3K1	2.06e-05	4	65	2	16557301
Pubmed	Hbo1 Links p53-dependent stress signaling to DNA replication licensing.	ING5 ING4	2.06e-05	4	65	2	17954561
Pubmed	p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.	ING5 ING4	2.06e-05	4	65	2	12750254
Pubmed	Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.	MAST1 MAST3	2.06e-05	4	65	2	15951562
Pubmed	JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.	MAPK8 MAP3K1	2.06e-05	4	65	2	14967141
Pubmed	A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma.	RIOK1 MTOR	2.06e-05	4	65	2	23459592
Pubmed	Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.	MAPK8 MAP3K1	2.06e-05	4	65	2	12878610
Pubmed	The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.	MTOR IDH1	2.06e-05	4	65	2	27624942
Pubmed	A malic enzyme probe detects cross-hybridizing sequences closely linked to loci encoding other metabolic enzymes.	MYO5A IDH1	2.06e-05	4	65	2	1346782
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	CLPP TPR KRT13 KRT15 MYO5A MCM7 PSME1 IDH1	3.31e-05	665	65	8	30457570
Pubmed	Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin.	MTOR MAPK8	3.43e-05	5	65	2	17942603
Pubmed	Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation.	MTOR MAPK8	3.43e-05	5	65	2	22493283
Pubmed	HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth.	MTOR MAPK8	3.43e-05	5	65	2	27043084
Pubmed	Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation.	ING5 ING4	3.43e-05	5	65	2	22144582
Pubmed	Repression of MAP3K1 expression and JNK activity by canonical Wnt signaling.	MAPK8 MAP3K1	3.43e-05	5	65	2	29787744
Pubmed	Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.	MAPK8 MAP3K1	3.43e-05	5	65	2	10713157
Pubmed	The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and ln.	MYO5A IDH1	3.43e-05	5	65	2	3410303
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	BLK PTPN12 AGO1 WASHC4 USP7 EIF3H MAPK8 MAP3K1 MAST3	4.76e-05	910	65	9	36736316
Pubmed	Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.	MAPK8 MAP3K1	5.13e-05	6	65	2	16434970
Pubmed	Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways.	MAPK8 MAP3K1	5.13e-05	6	65	2	11884395
Pubmed	A role for USP7 in DNA replication.	USP7 MCM7	5.13e-05	6	65	2	24190967
Pubmed	Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation.	MAPK8 MAP3K1	5.13e-05	6	65	2	12228228
Pubmed	MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation.	MAPK8 MAP3K1	5.13e-05	6	65	2	21152872
Pubmed	Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch.	MAPK8 MAP3K1	5.13e-05	6	65	2	15358865
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	TPR DCAF15 BRD8 SF3B1 WASHC4 STXBP4 TMED2 EIF3H GNAT1 FLOT1	5.35e-05	1155	65	10	20360068
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	TPR SF3B1 ZMYND8 USP7 MCM7	5.87e-05	220	65	5	35785414
Pubmed	MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.	NKD2 USP7 MFN2	6.31e-05	41	65	3	34964862
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	TPR RIOK1 SF3B1 MYO5A MAT1A USP7 MCM7 FLOT1 NGDN	6.56e-05	949	65	9	36574265
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	BRD8 ING5 ING4	6.79e-05	42	65	3	16387653
Pubmed	Negative regulation of MEKK1-induced signaling by glutathione S-transferase Mu.	MAPK8 MAP3K1	7.18e-05	7	65	2	15299005
Pubmed	ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.	ING5 ING4	7.18e-05	7	65	2	38446206
Pubmed	ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.	ING5 ING4	7.18e-05	7	65	2	16728974
Pubmed	Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals.	MAPK8 MAP3K1	7.18e-05	7	65	2	16636664
Pubmed	A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.	MAPK8 MAP3K1	7.18e-05	7	65	2	17681137
Pubmed	Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.	MAPK8 MAP3K1	7.18e-05	7	65	2	12763138
Pubmed	Mutational Hotspot of TET2, IDH1, IDH2, SRSF2, SF3B1, KRAS, and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast Cell Tumors.	SF3B1 IDH1	7.18e-05	7	65	2	26562302
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	TPR RIOK1 USP7 MCM7	7.51e-05	119	65	4	35776542
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	WASHC4 MYO5A INTS7 MTOR STXBP4 USP7 EIF3H NGDN	7.98e-05	754	65	8	33060197
Pubmed	JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.	MAPK8 MAP3K1	9.56e-05	8	65	2	9808624
Pubmed	Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.	GINS4 MCM7	9.56e-05	8	65	2	19805216
Pubmed	Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.	MAPK8 MAP3K1	9.56e-05	8	65	2	10346818
Pubmed	G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells.	MAPK8 MAP3K1	9.56e-05	8	65	2	18187455
Pubmed	Subdomain VIII is a specificity-determining region in MEKK1.	MAPK8 MAP3K1	9.56e-05	8	65	2	14500727
Pubmed	An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line.	MAPK8 MAP3K1	9.56e-05	8	65	2	34078823
Pubmed	Hdac6 regulates Tip60-p400 function in stem cells.	TPR BRD8 SF3B1	1.01e-04	48	65	3	24302573
Pubmed	Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.	MTOR MAPK8	1.23e-04	9	65	2	11279232
Pubmed	ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.	MAPK8 MAP3K1	1.23e-04	9	65	2	19270716
Pubmed	JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.	MAPK8 MAP3K1	1.23e-04	9	65	2	10523642
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SF3B1 WASHC4 MYO5A ZMYND8 ADGRB3 USP7 MAST1 PSME1 FLOT1 SULT4A1	1.29e-04	1285	65	10	35914814
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	RIOK1 INTS7 MTOR GINS4 GNAT1 FLOT1	1.34e-04	419	65	6	33001583
Pubmed	Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.	MTOR USP7 PSME1	1.37e-04	53	65	3	35216969
Pubmed	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	MTOR EIF3H	1.53e-04	10	65	2	16286006
Pubmed	Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase.	GINS4 MCM7	1.53e-04	10	65	2	35920641
Pubmed	Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.	MTOR FLOT1	1.53e-04	10	65	2	21413931
Pubmed	Common genetic variants associated with breast cancer and mammographic density measures that predict disease.	STXBP4 MAP3K1	1.53e-04	10	65	2	20145138
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	TPR SF3B1 UPF2 ADGRB3 MCM7 PSME1 EIF3H FLOT1	1.77e-04	847	65	8	35235311
Pubmed	Eyelid closure in embryogenesis is required for ocular adnexa development.	KRT13 MAP3K1	1.87e-04	11	65	2	25377219
Pubmed	NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling.	MTOR MAPK8	1.87e-04	11	65	2	25555806
Pubmed	Genotyping new BXD recombinant inbred mouse strains and comparison of BXD and consensus maps.	MYO5A IDH1	1.87e-04	11	65	2	10087289
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	BLK PHF2 SF3B1 GINS4 IDH1	1.91e-04	283	65	5	18854154
Pubmed	Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7.	GINS4 MCM7	2.24e-04	12	65	2	24299456
Pubmed	Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.	GINS4 MCM7	2.24e-04	12	65	2	22474384
Pubmed	Airway basal cells show regionally distinct potential to undergo metaplastic differentiation.	KRT13 KRT15	2.24e-04	12	65	2	36178196
Interaction	MINDY4 interactions	KRT13 KRT15 SF3B1 USP7 EIF3H	3.50e-06	73	64	5	int:MINDY4
GeneFamily	Adhesion G protein-coupled receptors, subfamily B	ADGRB1 ADGRB3	2.07e-05	3	48	2	912
GeneFamily	Keratins, type I	KRT13 KRT15 KRT37	5.49e-05	28	48	3	608
GeneFamily	PHD finger proteins	PHF2 ZMYND8 ING5 ING4	9.45e-05	90	48	4	88
GeneFamily	PDZ domain containing	MAST4 STXBP4 MAST1 MAST3	7.01e-04	152	48	4	1220
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A	TPR DCAF15 MAST4 USP7 ING4 TMED2 MAST3 NGDN	8.28e-08	198	64	8	5246_DN
Disease	squamous cell carcinoma (implicated_via_orthology)	ING5 ING4	1.34e-05	3	63	2	DOID:1749 (implicated_via_orthology)
Disease	melanoma (implicated_via_orthology)	ING5 ING4	1.25e-04	8	63	2	DOID:1909 (implicated_via_orthology)
Disease	hepatocellular carcinoma (implicated_via_orthology)	ING5 ING4 MCM7	1.59e-04	49	63	3	DOID:684 (implicated_via_orthology)
Disease	pancreatic adenocarcinoma (is_marker_for)	ADGRB1 MAPK8	2.00e-04	10	63	2	DOID:4074 (is_marker_for)
Disease	prefrontal cortex growth measurement	TENM4 EIF3H	4.02e-04	14	63	2	EFO_0009334
Disease	hepatocellular carcinoma (is_marker_for)	SF3B1 MTOR MCM7 MAPK8 MAP3K1	4.63e-04	301	63	5	DOID:684 (is_marker_for)
Disease	glioblastoma (is_implicated_in)	ADGRB1 IDH1	1.20e-03	24	63	2	DOID:3068 (is_implicated_in)
Disease	Lymphatic Metastasis	MTOR ING4	1.41e-03	26	63	2	C0024232
Disease	primary aldosteronism	BRD8 ADGRB3	1.41e-03	26	63	2	MONDO_0001422
Disease	Glioblastoma Multiforme	MTOR IDH1 MAPK8	1.75e-03	111	63	3	C1621958
Disease	myelodysplastic syndrome (is_implicated_in)	SF3B1 IDH1	1.88e-03	30	63	2	DOID:0050908 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
IMYMDVRIQAPHEDL	CEACAM18	306	A8MTB9
EVQYQMEMMRSLRHV	EIF3H	96	O15372
HDVYHMAVEMQRDVL	BRD8	791	Q9H0E9
SIDYRNIQMMTREHL	ADGRB1	636	O14514
IVHPQERMMESDYIV	ADGRB3	1296	O60242
RRVNREVVEYMVQHF	AGO1	66	Q9UL18
RRMMSVYNHVLEEVE	INTS7	746	Q9NVH2
MTFRERTERHEMQIL	NPSR1	351	Q6W5P4
LNMRRDVKEIYSHMT	GNAT1	306	P11488
VMLYMRNVSHEELQR	NLRP8	41	Q86W28
RVLGEMRAQYEAMVE	KRT37	271	O76014
TRVLAEMREQYEAMA	KRT13	271	P13646
IMAHMTVEEIYKDRQ	FLOT1	111	O75955
CQVIQMELDHERMSY	MAPK8	116	P45983
ITSMAMVDYQRVVRD	MAT1A	71	Q00266
LTRVLAEMREQYEAM	KRT15	271	P19012
EEEHRMVYEMVQRIL	RALGAPA2	381	Q2PPJ7
REDMSSLMHTIYEVV	NKD2	141	Q969F2
FETRRHLCMVMEYVE	MAST1	441	Q9Y2H9
VYIEHRLMMEQRSRD	MCM7	101	P33993
EPEYMEEVRRQHMER	MFN2	266	O95140
IMDTYFQDVRMRIHL	ADAM30	236	Q9UKF2
YEHRLIDDMVAQAMK	IDH1	246	O75874
DYESIHDRLQMEREM	CC2D2A	271	Q9P2K1
RTYTQAMVEKMHELV	FAM151A	221	Q8WW52
QEVRAVSMPDYMVHE	C7orf57	116	Q8NEG2
EGMAYIERMNSIHRD	BLK	346	P51451
HDLYTLQRERMENDM	AXDND1	376	Q5T1B0
AMQTYEMVDKHIRRL	ING5	86	Q8WYH8
DNEIVMMNHVYRERF	MAST3	166	O60307
SFETRRHLCMVMEYV	MAST4	636	O15021
SEIMNNVHRIMTRYT	FAM186A	71	A6NE01
VLEMEVMRRQLYAVN	FATE1	131	Q969F0
SAMQEMEVYVENIRR	ZMYND8	341	Q9ULU4
DIRLMVMEIRNAYAV	PSME1	211	Q06323
MMSDENHRDIYVSTV	DCAF15	171	Q66K64
AMQTYEMVDKHIRRL	ING4	86	Q9UNL4
QAMHLDARYVTMVEN	UPF2	736	Q9HAU5
HYVTMELREMSQEES	MTOR	46	P42345
HIRPYMDEIVTLMRE	MTOR	1026	P42345
YQRDLEERMVHKVTM	MROH2A	491	A6NES4
EVVEALREEIRMMSH	MAP3K1	1286	Q13233
LQMVNASLYEHVERM	PLEKHM1	901	Q9Y4G2
DFFMRHSVAVMTVRE	RIOK1	366	Q9BRS2
HRMEILRGMYEELNE	TRIM49	221	P0CI25
SVEMQMRAYEVERRL	PHF2	341	O75151
SIHQMEMERIRYVLS	GINS4	76	Q9BRT9
VMHMSQRNAVDLVYR	LAMA1	1856	P25391
DMISLMRKYQEHEDV	PTPN12	211	Q05209
RQAHGMEMDYEEVIR	STXBP4	361	Q6ZWJ1
SLQVIESAMERDRYM	CLPP	216	Q16740
SREFIERSHQIERMM	TMPRSS11F	81	Q6ZWK6
QHRINYEESMMVRLS	NGDN	236	Q8NEJ9
YEDMHRDLVTMVEQL	SULT4A1	196	Q9BR01
VYVTVIIEVGRMHMQ	RNF148	171	Q8N7C7
MQLVDSIVRQRDMYR	TPR	601	P12270
TYMDVMREQHLTKEE	SF3B1	151	O75533
LRHIMAEMIATEREY	PLEKHG4B	806	Q96PX9
HRMEILRGMYEELNE	TRIM49C	221	P0CI26
DRFFVMETIIMRHEE	TENM4	991	Q6N022
MTAVKHEQEYMEVRE	TMED2	141	Q15363
IEHMFYRRSMVVADS	WASHC4	486	Q2M389
AIVMMGRHQYINEDE	USP7	1041	Q93009
IAQVRDEMDRMVYRV	MXRA5	556	Q9NR99
RYDDLKEEMTLMVHV	MYO5A	1091	Q9Y4I1
HEARRMIEGVVYEMR	MYBPC3	831	Q14896