Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of interleukin-2 production	SPTBN1 PLCG2 IL1A STAT5A STAT5B	5.88e-07	42	80	5	GO:0032743
GeneOntologyBiologicalProcess	growth hormone receptor signaling pathway via JAK-STAT	STAT3 STAT5A STAT5B	6.61e-06	10	80	3	GO:0060397
GeneOntologyBiologicalProcess	development of secondary female sexual characteristics	WNT5A STAT5A STAT5B	6.61e-06	10	80	3	GO:0046543
GeneOntologyBiologicalProcess	response to interleukin-2	STAT3 STAT5A STAT5B	9.07e-06	11	80	3	GO:0070669
GeneOntologyBiologicalProcess	regulation of interleukin-2 production	SPTBN1 PLCG2 IL1A STAT5A STAT5B	1.01e-05	74	80	5	GO:0032663
GeneOntologyBiologicalProcess	response to interleukin-15	STAT3 STAT5A STAT5B	1.21e-05	12	80	3	GO:0070672
GeneOntologyBiologicalProcess	development of secondary sexual characteristics	WNT5A STAT5A STAT5B	1.56e-05	13	80	3	GO:0045136
GeneOntologyBiologicalProcess	interleukin-2 production	SPTBN1 PLCG2 IL1A STAT5A STAT5B	1.67e-05	82	80	5	GO:0032623
GeneOntologyBiologicalProcess	mitotic actomyosin contractile ring assembly	IQGAP3 IQGAP1	4.45e-05	3	80	2	GO:1903475
GeneOntologyBiologicalProcess	mitotic actomyosin contractile ring assembly actin filament organization	IQGAP3 IQGAP1	4.45e-05	3	80	2	GO:1903479
GeneOntologyBiologicalProcess	assembly of actomyosin apparatus involved in mitotic cytokinesis	IQGAP3 IQGAP1	4.45e-05	3	80	2	GO:1902407
GeneOntologyBiologicalProcess	development of secondary male sexual characteristics	STAT5A STAT5B	4.45e-05	3	80	2	GO:0046544
GeneOntologyBiologicalProcess	T cell differentiation in thymus	CD3G MINK1 IL1A STAT5A STAT5B	8.16e-05	114	80	5	GO:0033077
GeneOntologyBiologicalProcess	actomyosin contractile ring assembly actin filament organization	IQGAP3 IQGAP1	8.87e-05	4	80	2	GO:2000689
GeneOntologyBiologicalProcess	T cell differentiation	CD3G MINK1 SMARCC2 LOXL3 IL1A STAT3 STAT5A STAT5B	1.17e-04	382	80	8	GO:0030217
GeneOntologyBiologicalProcess	growth hormone receptor signaling pathway	STAT3 STAT5A STAT5B	1.37e-04	26	80	3	GO:0060396
GeneOntologyBiologicalProcess	cytokinesis	PKP4 SPTBN1 UVRAG IQGAP3 IQGAP1 CEP55	1.42e-04	204	80	6	GO:0000910
GeneOntologyBiologicalProcess	T cell selection	CD3G MINK1 LOXL3 STAT3	1.50e-04	69	80	4	GO:0045058
GeneOntologyBiologicalProcess	cellular response to growth hormone stimulus	STAT3 STAT5A STAT5B	1.54e-04	27	80	3	GO:0071378
GeneOntologyBiologicalProcess	actin filament-based process	TTC8 MYH2 MYH8 HMCN1 SPTBN1 MINK1 GJC1 IL1A TRIP10 IQGAP3 MAP3K1 IQGAP1	1.96e-04	912	80	12	GO:0030029
GeneOntologyBiologicalProcess	lymphocyte differentiation	CD3G MINK1 SMARCC2 LOXL3 PLCG2 IL1A STAT3 STAT5A STAT5B	2.31e-04	537	80	9	GO:0030098
GeneOntologyBiologicalProcess	gamma-delta T cell activation	CD3G STAT5A STAT5B	2.82e-04	33	80	3	GO:0046629
GeneOntologyBiologicalProcess	mitotic cytokinetic process	IQGAP3 IQGAP1 CEP55	2.82e-04	33	80	3	GO:1902410
GeneOntologyBiologicalProcess	prostate gland epithelium morphogenesis	FEM1B WNT5A STAT5A	2.82e-04	33	80	3	GO:0060740
GeneOntologyBiologicalProcess	cellular response to interleukin-9	STAT3 STAT5A	3.08e-04	7	80	2	GO:0071355
GeneOntologyBiologicalProcess	interleukin-9-mediated signaling pathway	STAT3 STAT5A	3.08e-04	7	80	2	GO:0038113
GeneOntologyBiologicalProcess	prostate gland morphogenesis	FEM1B WNT5A STAT5A	3.08e-04	34	80	3	GO:0060512
GeneOntologyBiologicalProcess	cell division	HMCN1 STAG1 TTC28 PKP4 SPTBN1 IL1A UVRAG IQGAP3 IQGAP1 CEP55	3.55e-04	697	80	10	GO:0051301
GeneOntologyBiologicalProcess	cell cycle process	FEM1B STAG1 WNT5A PKP4 SPTBN1 SMARCC2 MSH4 PLCG2 CCDC102B PIBF1 IL1A UVRAG IQGAP3 IQGAP1 CEP55	3.80e-04	1441	80	15	GO:0022402
GeneOntologyBiologicalProcess	response to interleukin-9	STAT3 STAT5A	4.10e-04	8	80	2	GO:0071104
GeneOntologyBiologicalProcess	positive regulation of cytokine production	WNT5A SPTBN1 PLCG2 PIBF1 IL1A CCDC88B STAT3 STAT5A STAT5B	4.37e-04	586	80	9	GO:0001819
GeneOntologyBiologicalProcess	mitotic cytokinesis	SPTBN1 IQGAP3 IQGAP1 CEP55	5.11e-04	95	80	4	GO:0000281
GeneOntologyBiologicalProcess	taurine metabolic process	STAT5A STAT5B	5.25e-04	9	80	2	GO:0019530
GeneOntologyBiologicalProcess	actomyosin contractile ring assembly	IQGAP3 IQGAP1	5.25e-04	9	80	2	GO:0000915
GeneOntologyBiologicalProcess	assembly of actomyosin apparatus involved in cytokinesis	IQGAP3 IQGAP1	5.25e-04	9	80	2	GO:0000912
GeneOntologyBiologicalProcess	cellular response to interleukin-2	STAT3 STAT5A	5.25e-04	9	80	2	GO:0071352
GeneOntologyBiologicalProcess	alkanesulfonate metabolic process	STAT5A STAT5B	5.25e-04	9	80	2	GO:0019694
GeneOntologyBiologicalProcess	interleukin-2-mediated signaling pathway	STAT3 STAT5A	5.25e-04	9	80	2	GO:0038110
GeneOntologyBiologicalProcess	response to growth hormone	STAT3 STAT5A STAT5B	5.39e-04	41	80	3	GO:0060416
GeneOntologyBiologicalProcess	actomyosin contractile ring organization	IQGAP3 IQGAP1	6.55e-04	10	80	2	GO:0044837
GeneOntologyBiologicalProcess	cellular response to interleukin-15	STAT3 STAT5A	7.99e-04	11	80	2	GO:0071350
GeneOntologyBiologicalProcess	interleukin-15-mediated signaling pathway	STAT3 STAT5A	7.99e-04	11	80	2	GO:0035723
GeneOntologyBiologicalProcess	negative regulation of erythrocyte differentiation	STAT5A STAT5B	7.99e-04	11	80	2	GO:0045647
GeneOntologyBiologicalProcess	positive regulation of JNK cascade	WNT5A MINK1 IL1A MAP3K1	8.00e-04	107	80	4	GO:0046330
GeneOntologyBiologicalProcess	mononuclear cell differentiation	CD3G MINK1 SMARCC2 LOXL3 PLCG2 IL1A STAT3 STAT5A STAT5B	8.21e-04	640	80	9	GO:1903131
GeneOntologyBiologicalProcess	cytokinetic process	IQGAP3 IQGAP1 CEP55	8.57e-04	48	80	3	GO:0032506
GeneOntologyBiologicalProcess	positive regulation of interleukin-10 production	PLCG2 PIBF1 STAT3	8.57e-04	48	80	3	GO:0032733
GeneOntologyBiologicalProcess	cell-cell adhesion	HMCN1 WNT5A PKP4 MINK1 LAMA3 SMARCC2 LOXL3 IL1A CCDC88B PDIA3 STAT5A STAT5B	8.71e-04	1077	80	12	GO:0098609
GeneOntologyBiologicalProcess	regulation of cell adhesion	WNT5A PKP4 MINK1 LAMA3 SMARCC2 LOXL3 IL1A CCDC88B STAT5A STAT5B IQGAP1	8.74e-04	927	80	11	GO:0030155
GeneOntologyBiologicalProcess	positive regulation of gamma-delta T cell differentiation	STAT5A STAT5B	9.56e-04	12	80	2	GO:0045588
GeneOntologyBiologicalProcess	positive regulation of natural killer cell differentiation	STAT5A STAT5B	9.56e-04	12	80	2	GO:0032825
GeneOntologyBiologicalProcess	regulation of cell cycle	GMNC FEM1B TTC28 WNT5A PKP4 SMARCC2 PLCG2 IL1A UVRAG STAT3 STAT5A STAT5B IQGAP1	1.03e-03	1256	80	13	GO:0051726
Domain	STAT_TF_prot_interaction	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	IPR013799
Domain	STAT_TF_DNA-bd_sub	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	IPR012345
Domain	STAT	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	IPR001217
Domain	STAT_TF_coiled-coil	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	IPR015988
Domain	-	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	2.60.40.630
Domain	STAT_int	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	SM00964
Domain	STAT_TF_DNA-bd	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	IPR013801
Domain	STAT_bind	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	PF02864
Domain	STAT_int	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	PF02865
Domain	-	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	1.10.532.10
Domain	STAT_alpha	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	PF01017
Domain	-	STAT3 STAT5A STAT5B	2.15e-06	7	75	3	1.20.1050.20
Domain	STAT_TF_alpha	STAT3 STAT5A STAT5B	3.43e-06	8	75	3	IPR013800
Domain	DGCR6	DGCR6 DGCR6L	1.59e-05	2	75	2	PF07324
Domain	Gonadal	DGCR6 DGCR6L	1.59e-05	2	75	2	IPR010849
Domain	RasGAP_C	IQGAP3 IQGAP1	4.76e-05	3	75	2	IPR000593
Domain	RasGAP_C	IQGAP3 IQGAP1	4.76e-05	3	75	2	PF03836
Domain	Myosin-like_IQ_dom	MYH2 MYH8 IQGAP1	5.75e-05	19	75	3	IPR027401
Domain	-	MYH2 MYH8 IQGAP1	5.75e-05	19	75	3	4.10.270.10
Domain	IQ	MYH2 MYH8 IQGAP3 IQGAP1	1.90e-04	71	75	4	PF00612
Domain	IQ	MYH2 MYH8 IQGAP3 IQGAP1	3.16e-04	81	75	4	SM00015
Domain	IQ_motif_EF-hand-BS	MYH2 MYH8 IQGAP3 IQGAP1	4.72e-04	90	75	4	IPR000048
Domain	IQ	MYH2 MYH8 IQGAP3 IQGAP1	5.34e-04	93	75	4	PS50096
Domain	TPR_7	TTC8 TTC28	7.01e-04	10	75	2	PF13176
Domain	SH2	PLCG2 STAT3 STAT5A STAT5B	7.29e-04	101	75	4	PF00017
Domain	SH2	PLCG2 STAT3 STAT5A STAT5B	1.00e-03	110	75	4	SM00252
Domain	SH2	PLCG2 STAT3 STAT5A STAT5B	1.04e-03	111	75	4	PS50001
Domain	TPR_2	TTC8 TTC28 TTC14	1.06e-03	50	75	3	PF07719
Domain	TPR_2	TTC8 TTC28 TTC14	1.06e-03	50	75	3	IPR013105
Domain	SH2	PLCG2 STAT3 STAT5A STAT5B	1.07e-03	112	75	4	IPR000980
Domain	-	PLCG2 STAT3 STAT5A STAT5B	1.07e-03	112	75	4	3.30.505.10
Domain	p53-like_TF_DNA-bd	STAT3 STAT5A STAT5B	1.26e-03	53	75	3	IPR008967
Domain	RasGAP	IQGAP3 IQGAP1	1.40e-03	14	75	2	SM00323
Domain	RasGAP_CS	IQGAP3 IQGAP1	1.40e-03	14	75	2	IPR023152
Domain	RasGAP	IQGAP3 IQGAP1	1.62e-03	15	75	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	IQGAP3 IQGAP1	1.62e-03	15	75	2	PS00509
Domain	Myosin_N	MYH2 MYH8	1.62e-03	15	75	2	PF02736
Domain	RAS_GTPASE_ACTIV_2	IQGAP3 IQGAP1	1.62e-03	15	75	2	PS50018
Domain	Myosin_N	MYH2 MYH8	1.62e-03	15	75	2	IPR004009
Domain	-	IQGAP3 IQGAP1	1.84e-03	16	75	2	1.10.506.10
Domain	CH	SPTBN1 IQGAP3 IQGAP1	2.27e-03	65	75	3	SM00033
Domain	Myosin_tail_1	MYH2 MYH8	2.34e-03	18	75	2	PF01576
Domain	Myosin_tail	MYH2 MYH8	2.34e-03	18	75	2	IPR002928
Domain	RasGAP_dom	IQGAP3 IQGAP1	2.34e-03	18	75	2	IPR001936
Domain	CH	SPTBN1 IQGAP3 IQGAP1	2.81e-03	70	75	3	PF00307
Domain	-	SPTBN1 IQGAP3 IQGAP1	2.92e-03	71	75	3	1.10.418.10
Domain	CH	SPTBN1 IQGAP3 IQGAP1	3.16e-03	73	75	3	PS50021
Domain	CH-domain	SPTBN1 IQGAP3 IQGAP1	3.41e-03	75	75	3	IPR001715
Domain	TPR_REGION	FEM1B TTC8 TTC28 TTC14	4.39e-03	165	75	4	PS50293
Domain	TPR	FEM1B TTC8 TTC28 TTC14	4.39e-03	165	75	4	PS50005
Domain	-	TMPRSS5 LOXL3	4.50e-03	25	75	2	3.10.250.10
Domain	HR1_rho-bd	PIBF1 TRIP10	4.50e-03	25	75	2	IPR011072
Domain	SRCR_1	TMPRSS5 LOXL3	4.86e-03	26	75	2	PS00420
Domain	SRCR_2	TMPRSS5 LOXL3	4.86e-03	26	75	2	PS50287
Domain	SRCR-like_dom	TMPRSS5 LOXL3	4.86e-03	26	75	2	IPR017448
Domain	SRCR	TMPRSS5 LOXL3	5.23e-03	27	75	2	IPR001190
Domain	TPR_1	TTC8 TTC28 TTC14	5.69e-03	90	75	3	PF00515
Domain	TPR_1	TTC8 TTC28 TTC14	5.69e-03	90	75	3	IPR001440
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY	STAT3 STAT5A STAT5B	6.57e-07	5	58	3	M48987
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	STAT3 STAT5A STAT5B	1.31e-06	6	58	3	MM15581
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	STAT3 STAT5A STAT5B	1.31e-06	6	58	3	MM15621
Pathway	KEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY	STAT3 STAT5A STAT5B	2.29e-06	7	58	3	M47430
Pathway	PID_RAC1_PATHWAY	IQGAP3 MAP3K1 STAT3 STAT5A IQGAP1	2.68e-06	54	58	5	M278
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	STAT3 STAT5A STAT5B	5.46e-06	9	58	3	M27861
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT3 STAT5A STAT5B	5.46e-06	9	58	3	MM1419
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT3 STAT5A STAT5B	5.46e-06	9	58	3	M8066
Pathway	WP_PDGFRBETA_PATHWAY	MAP3K1 STAT3 STAT5A STAT5B	5.67e-06	29	58	4	M39616
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	STAT3 STAT5A STAT5B	7.77e-06	10	58	3	M27898
Pathway	REACTOME_SIGNALING_BY_LEPTIN	STAT3 STAT5A STAT5B	1.07e-05	11	58	3	M27195
Pathway	REACTOME_INTERLEUKIN_15_SIGNALING	STAT3 STAT5A STAT5B	1.07e-05	11	58	3	MM15578
Pathway	BIOCARTA_IL10_PATHWAY	IL1A STAT3 STAT5A	1.42e-05	12	58	3	MM1416
Pathway	BIOCARTA_IL10_PATHWAY	IL1A STAT3 STAT5A	1.84e-05	13	58	3	M6778
Pathway	REACTOME_INTERLEUKIN_15_SIGNALING	STAT3 STAT5A STAT5B	2.33e-05	14	58	3	M27858
Pathway	WP_FOXP3_IN_COVID19	STAT3 STAT5A STAT5B	2.90e-05	15	58	3	M42573
Pathway	REACTOME_INTERLEUKIN_7_SIGNALING	STAT3 STAT5A STAT5B	2.90e-05	15	58	3	MM14536
Pathway	WP_IL9_SIGNALING	STAT3 STAT5A STAT5B	4.31e-05	17	58	3	M39644
Pathway	KEGG_MEDICUS_REFERENCE_HORMONE_LIKE_CYTOKINE_TO_JAK_STAT_SIGNALING_PATHWAY	STAT3 STAT5A STAT5B	4.31e-05	17	58	3	M47905
Pathway	REACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS	STAT3 STAT5A STAT5B	5.16e-05	18	58	3	M673
Pathway	REACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS	SPTBN1 STAT5A STAT5B	6.11e-05	19	58	3	M41732
Pathway	REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING	STAT3 STAT5A STAT5B	7.17e-05	20	58	3	MM15496
Pathway	REACTOME_SIGNALING_BY_KIT_IN_DISEASE	STAT3 STAT5A STAT5B	7.17e-05	20	58	3	M39002
Pathway	BIOCARTA_GLEEVEC_PATHWAY	MAP3K1 STAT5A STAT5B	1.10e-04	23	58	3	MM1424
Pathway	BIOCARTA_GLEEVEC_PATHWAY	MAP3K1 STAT5A STAT5B	1.10e-04	23	58	3	M7897
Pathway	KEGG_MEDICUS_REFERENCE_IL2_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY	STAT3 STAT5A STAT5B	1.10e-04	23	58	3	M47904
Pathway	BIOCARTA_TPO_PATHWAY	STAT3 STAT5A STAT5B	1.26e-04	24	58	3	M11520
Pathway	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	STAT3 STAT5A STAT5B	1.26e-04	24	58	3	M519
Pathway	REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING	STAT3 STAT5A STAT5B	1.43e-04	25	58	3	M41829
Pathway	BIOCARTA_TPO_PATHWAY	STAT3 STAT5A STAT5B	1.43e-04	25	58	3	MM1519
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	PLCG2 STAT5A STAT5B	1.43e-04	25	58	3	M27865
Pathway	WP_IL7_SIGNALING	STAT3 STAT5A STAT5B	1.43e-04	25	58	3	M39499
Pathway	REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING	STAT3 STAT5A STAT5B	1.61e-04	26	58	3	M27750
Pathway	WP_EPO_RECEPTOR_SIGNALING	STAT3 STAT5A STAT5B	1.61e-04	26	58	3	M39687
Pathway	WP_EPO_RECEPTOR_SIGNALING	STAT3 STAT5A STAT5B	1.61e-04	26	58	3	MM15896
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	1.65e-04	5	58	2	M48986
Pathway	KEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	1.65e-04	5	58	2	M49006
Pathway	REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	STAT3 STAT5A STAT5B	1.80e-04	27	58	3	MM14712
Pathway	BIOCARTA_EGF_PATHWAY	MAP3K1 STAT3 STAT5A	1.80e-04	27	58	3	M1909
Pathway	BIOCARTA_EGF_PATHWAY	MAP3K1 STAT3 STAT5A	2.01e-04	28	58	3	MM1386
Pathway	REACTOME_FLT3_SIGNALING_IN_DISEASE	SPTBN1 STAT5A STAT5B	2.01e-04	28	58	3	M41724
Pathway	BIOCARTA_PDGF_PATHWAY	MAP3K1 STAT3 STAT5A	2.01e-04	28	58	3	M2529
Pathway	WP_NONSMALL_CELL_LUNG_CANCER	PLCG2 STAT3 STAT5A STAT5B	2.15e-04	72	58	4	M39738
Pathway	BIOCARTA_PDGF_PATHWAY	MAP3K1 STAT3 STAT5A	2.24e-04	29	58	3	MM1452
Pathway	REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	STAT3 STAT5A STAT5B	2.24e-04	29	58	3	M779
Pathway	WP_MEASLES_VIRUS_INFECTION	CD3G IL1A STAT3 STAT5A STAT5B	2.36e-04	136	58	5	M42547
Pathway	REACTOME_SIGNALING_BY_CSF3_G_CSF	STAT3 STAT5A STAT5B	2.48e-04	30	58	3	M41825
Pathway	WP_JOUBERT_SYNDROME	TTC8 PDE6B CC2D2A PIBF1	2.65e-04	76	58	4	M39835
Pathway	REACTOME_FGFR1_MUTANT_RECEPTOR_ACTIVATION	STAT3 STAT5A STAT5B	2.74e-04	31	58	3	M661
Pathway	PID_EPO_PATHWAY	PLCG2 STAT5A STAT5B	3.30e-04	33	58	3	M233
Pathway	REACTOME_STAT5_ACTIVATION	STAT5A STAT5B	3.45e-04	7	58	2	M27953
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	3.45e-04	7	58	2	M47581
Pathway	KEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	3.45e-04	7	58	2	M47646
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5	STAT5A STAT5B	3.45e-04	7	58	2	M27907
Pathway	WP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS	STAT3 STAT5A STAT5B	3.61e-04	34	58	3	M48081
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	STAT3 STAT5A STAT5B	3.94e-04	35	58	3	MM15144
Pathway	REACTOME_INTERLEUKIN_7_SIGNALING	STAT3 STAT5A STAT5B	4.29e-04	36	58	3	M542
Pathway	PID_GMCSF_PATHWAY	STAT3 STAT5A STAT5B	4.29e-04	36	58	3	M22
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	STAT3 STAT5A STAT5B	4.65e-04	37	58	3	MM14564
Pathway	REACTOME_SIGNALING_BY_FGFR1_IN_DISEASE	STAT3 STAT5A STAT5B	5.03e-04	38	58	3	M27536
Pathway	WP_EGFEGFR_SIGNALING	MAP3K1 STAT3 STAT5A STAT5B IQGAP1	5.28e-04	162	58	5	M39334
Pathway	WP_IL5_SIGNALING	STAT3 STAT5A STAT5B	5.86e-04	40	58	3	M39392
Pathway	WP_IL2_SIGNALING	STAT3 STAT5A STAT5B	6.77e-04	42	58	3	M39536
Pathway	PID_TCPTP_PATHWAY	STAT3 STAT5A STAT5B	6.77e-04	42	58	3	M91
Pathway	WP_IL7_SIGNALING_PATHWAY	STAT3 STAT5A STAT5B	7.26e-04	43	58	3	MM15864
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	STAT3 STAT5A STAT5B	7.26e-04	43	58	3	M508
Pathway	REACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS	STAT5A STAT5B	7.33e-04	10	58	2	M41731
Pathway	REACTOME_INTERLEUKIN_2_SIGNALING	STAT5A STAT5B	7.33e-04	10	58	2	MM15618
Pathway	PID_CXCR4_PATHWAY	CD3G STAT3 STAT5A STAT5B	7.54e-04	100	58	4	M124
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	STAT3 STAT5A STAT5B	7.77e-04	44	58	3	M1012
Pathway	KEGG_MEDICUS_REFERENCE_CYTOKINE_JAK_STAT_SIGNALING_PATHWAY	STAT3 STAT5A STAT5B	8.30e-04	45	58	3	M47408
Pathway	WP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING	STAT3 STAT5A STAT5B	9.42e-04	47	58	3	M39380
Pathway	WP_EGFR1_SIGNALING_PATHWAY	PLCG2 MAP3K1 STAT3 STAT5A STAT5B	1.03e-03	188	58	5	MM15828
Pathway	WP_IL3_SIGNALING	STAT3 STAT5A STAT5B	1.06e-03	49	58	3	M39722
Pathway	WP_IL10_ANTIINFLAMMATORY_SIGNALING	IL1A STAT3	1.07e-03	12	58	2	M39796
Pathway	REACTOME_INTERLEUKIN_2_SIGNALING	STAT5A STAT5B	1.07e-03	12	58	2	M27893
Pathway	REACTOME_LYSINE_CATABOLISM	PHYKPL AASS	1.07e-03	12	58	2	M27680
Pathway	REACTOME_LYSINE_CATABOLISM	PHYKPL AASS	1.07e-03	12	58	2	MM15400
Pathway	PID_PTP1B_PATHWAY	STAT3 STAT5A STAT5B	1.27e-03	52	58	3	M50
Pathway	WP_IL4_SIGNALING	STAT3 STAT5A STAT5B	1.41e-03	54	58	3	M39720
Pathway	WP_INTERFERON_TYPE_I_SIGNALING	MAP3K1 STAT3 STAT5A	1.41e-03	54	58	3	M39435
Pathway	PID_IL5_PATHWAY	STAT5A STAT5B	1.47e-03	14	58	2	M135
Pathway	PID_IL2_1PATHWAY	STAT3 STAT5A STAT5B	1.49e-03	55	58	3	M122
Pathway	KEGG_ACUTE_MYELOID_LEUKEMIA	STAT3 STAT5A STAT5B	1.65e-03	57	58	3	M19888
Pathway	REACTOME_SIGNALING_BY_PDGF	STAT3 STAT5A STAT5B	1.65e-03	57	58	3	MM14713
Pathway	REACTOME_PROLACTIN_RECEPTOR_SIGNALING	STAT5A STAT5B	1.69e-03	15	58	2	M552
Pathway	BIOCARTA_IL3_PATHWAY	STAT5A STAT5B	1.69e-03	15	58	2	MM1412
Pathway	BIOCARTA_IL3_PATHWAY	STAT5A STAT5B	1.69e-03	15	58	2	M17681
Pathway	REACTOME_SIGNALING_BY_PDGF	STAT3 STAT5A STAT5B	1.74e-03	58	58	3	M2049
Pathway	REACTOME_RHOQ_GTPASE_CYCLE	TRIP10 IQGAP3 IQGAP1	1.74e-03	58	58	3	MM15602
Pathway	WP_KIT_RECEPTOR_SIGNALING	STAT3 STAT5A STAT5B	1.82e-03	59	58	3	M39350
Pathway	REACTOME_RHOQ_GTPASE_CYCLE	TRIP10 IQGAP3 IQGAP1	1.82e-03	59	58	3	M41812
Pathway	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	STAT5A STAT5B	1.92e-03	16	58	2	MM15710
Pathway	BIOCARTA_IL7_PATHWAY	STAT5A STAT5B	1.92e-03	16	58	2	M1296
Pathway	BIOCARTA_IL7_PATHWAY	STAT5A STAT5B	1.92e-03	16	58	2	MM1420
Pathway	REACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS	STAT5A STAT5B	1.92e-03	16	58	2	M41733
Pathway	PID_PDGFRB_PATHWAY	STAT3 STAT5A STAT5B IQGAP1	1.94e-03	129	58	4	M186
Pathway	REACTOME_LEISHMANIA_INFECTION	MYH2 CD3G WNT5A PLCG2 IL1A	2.03e-03	219	58	5	M29836
Pathway	PID_IL12_2PATHWAY	CD3G STAT3 STAT5A	2.10e-03	62	58	3	M54
Pathway	KEGG_PATHWAYS_IN_CANCER	WNT5A LAMA3 PLCG2 STAT3 STAT5A STAT5B	2.12e-03	325	58	6	M12868
Pubmed	Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.	STAT3 STAT5A STAT5B	1.17e-08	3	80	3	20201032
Pubmed	Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism.	STAT3 STAT5A STAT5B	1.17e-08	3	80	3	19796718
Pubmed	IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts.	STAT3 STAT5A STAT5B	1.17e-08	3	80	3	9398404
Pubmed	The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8.	STAT3 STAT5A STAT5B	1.17e-08	3	80	3	18342552
Pubmed	IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis.	STAT3 STAT5A STAT5B	4.68e-08	4	80	3	32332067
Pubmed	Differential effects of STAT proteins on growth hormone-mediated IGF-I gene expression.	STAT3 STAT5A STAT5B	4.68e-08	4	80	3	25205818
Pubmed	The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.	STAT3 STAT5A STAT5B	4.68e-08	4	80	3	7719938
Pubmed	Degradation of the transcription factors NF-κB, STAT3, and STAT5 is involved in Entamoeba histolytica-induced cell death in Caco-2 colonic epithelial cells.	STAT3 STAT5A STAT5B	4.68e-08	4	80	3	25352693
Pubmed	Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes.	STAT3 STAT5A STAT5B	4.68e-08	4	80	3	15634877
Pubmed	Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice.	STAT3 STAT5A STAT5B	4.68e-08	4	80	3	23696567
Pubmed	Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer.	STAT3 STAT5A STAT5B	4.68e-08	4	80	3	17639043
Pubmed	STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.	STAT3 STAT5A STAT5B	4.68e-08	4	80	3	23716595
Pubmed	The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma.	STAT3 STAT5A STAT5B	4.68e-08	4	80	3	28422733
Pubmed	IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.	IL1A STAT3 STAT5A STAT5B	6.04e-08	17	80	4	19666510
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ZNF106 SETX TTC28 AASS SPTBN1 MINK1 FRYL PIBF1 ZNF598 DNMBP UVRAG STAT3 LUZP1	8.19e-08	861	80	13	36931259
Pubmed	PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5.	STAT3 STAT5A STAT5B	1.17e-07	5	80	3	29794014
Pubmed	The Current STATus of lymphocyte signaling: new roles for old players.	STAT3 STAT5A STAT5B	1.17e-07	5	80	3	19362457
Pubmed	The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development.	STAT3 STAT5A STAT5B	1.17e-07	5	80	3	23033267
Pubmed	Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.	STAT3 STAT5A STAT5B	1.17e-07	5	80	3	15677474
Pubmed	N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.	STAT3 STAT5A STAT5B	2.33e-07	6	80	3	14704793
Pubmed	Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3.	STAT3 STAT5A STAT5B	2.33e-07	6	80	3	17082570
Pubmed	Nonredundant roles for Stat5a/b in directly regulating Foxp3.	STAT3 STAT5A STAT5B	2.33e-07	6	80	3	17227828
Pubmed	Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5.	STAT3 STAT5A STAT5B	2.33e-07	6	80	3	21278738
Pubmed	Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile.	STAT3 STAT5A STAT5B	2.33e-07	6	80	3	27870635
Pubmed	Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions.	STAT3 STAT5A STAT5B	2.33e-07	6	80	3	12704203
Pubmed	Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.	STAT3 STAT5A STAT5B	2.33e-07	6	80	3	17363300
Pubmed	Association of STATs with relatives and friends.	STAT3 STAT5A STAT5B	2.33e-07	6	80	3	10675904
Pubmed	Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.	STAT3 STAT5A STAT5B	2.33e-07	6	80	3	17951529
Pubmed	Transcriptional and physiological roles for STAT proteins in leptin action.	STAT3 STAT5A STAT5B	4.07e-07	7	80	3	30718218
Pubmed	STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.	STAT3 STAT5A STAT5B	4.07e-07	7	80	3	23797472
Pubmed	Signaling through the JAK/STAT pathway, recent advances and future challenges.	STAT3 STAT5A STAT5B	4.07e-07	7	80	3	12039028
Pubmed	Expression and activation of STAT proteins during mouse retina development.	STAT3 STAT5A STAT5B	4.07e-07	7	80	3	12634107
Pubmed	STAT heterodimers in immunity: A mixed message or a unique signal?	STAT3 STAT5A STAT5B	4.07e-07	7	80	3	24058793
Pubmed	Physiological significance of STAT proteins: investigations through gene disruption in vivo.	STAT3 STAT5A STAT5B	4.07e-07	7	80	3	10526573
Pubmed	Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.	STAT3 STAT5A STAT5B	6.51e-07	8	80	3	9989503
Pubmed	Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.	STAT3 STAT5A STAT5B	6.51e-07	8	80	3	10602027
Pubmed	The Jak-STAT pathway.	STAT3 STAT5A STAT5B	9.75e-07	9	80	3	10781830
Pubmed	A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach.	PLCG2 STAT5A STAT5B	9.75e-07	9	80	3	15644415
Pubmed	Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains.	STAT3 STAT5A STAT5B	9.75e-07	9	80	3	9484840
Pubmed	A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon α.	STAT3 STAT5A STAT5B	9.75e-07	9	80	3	20065083
Pubmed	Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse.	STAT3 STAT5A STAT5B	1.39e-06	10	80	3	11161808
Pubmed	Cytokines, Jaks, Stats, health and disease.	STAT3 STAT5A STAT5B	1.39e-06	10	80	3	10200816
Pubmed	JAK-STAT signaling maintains homeostasis in T cells and macrophages.	STAT3 STAT5A STAT5B	1.39e-06	10	80	3	38658806
Pubmed	A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing.	STAT3 STAT5A STAT5B	1.39e-06	10	80	3	17485440
Pubmed	JAK-STAT and bone metabolism.	STAT3 STAT5A STAT5B	1.39e-06	10	80	3	24069548
Pubmed	Distribution of the mammalian Stat gene family in mouse chromosomes.	STAT3 STAT5A STAT5B	3.30e-06	13	80	3	8530075
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	ATAD3A PKP4 SPTBN1 MINK1 RAPGEF4 LUZP1 IQGAP1	4.01e-06	281	80	7	28706196
Pubmed	Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice.	STAT3 STAT5A STAT5B	4.19e-06	14	80	3	12753872
Pubmed	Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.	STAT5A STAT5B	5.23e-06	2	80	2	23151802
Pubmed	Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.	STAT5A STAT5B	5.23e-06	2	80	2	26999798
Pubmed	Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.	STAT3 STAT5B	5.23e-06	2	80	2	20167868
Pubmed	The Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia.	STAT3 STAT5A	5.23e-06	2	80	2	26146825
Pubmed	A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.	STAT5A STAT5B	5.23e-06	2	80	2	31443474
Pubmed	Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.	STAT5A STAT5B	5.23e-06	2	80	2	12377952
Pubmed	Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line.	PDIA3 STAT3	5.23e-06	2	80	2	19995546
Pubmed	Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.	STAT3 STAT5A	5.23e-06	2	80	2	15998795
Pubmed	A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.	STAT5A STAT5B	5.23e-06	2	80	2	21127177
Pubmed	The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.	STAT5A STAT5B	5.23e-06	2	80	2	16289657
Pubmed	Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.	STAT5A STAT5B	5.23e-06	2	80	2	25552366
Pubmed	Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.	STAT5A STAT5B	5.23e-06	2	80	2	25470773
Pubmed	STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells.	STAT3 STAT5A	5.23e-06	2	80	2	26976954
Pubmed	ERp57 modulates STAT3 signaling from the lumen of the endoplasmic reticulum.	PDIA3 STAT3	5.23e-06	2	80	2	20022947
Pubmed	Constitutively active Stat5A and Stat5B promote adipogenesis.	STAT5A STAT5B	5.23e-06	2	80	2	21431790
Pubmed	Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells.	PDIA3 STAT3	5.23e-06	2	80	2	30612517
Pubmed	Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.	STAT5A STAT5B	5.23e-06	2	80	2	28500076
Pubmed	STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.	STAT5A STAT5B	5.23e-06	2	80	2	21826656
Pubmed	Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.	STAT5A STAT5B	5.23e-06	2	80	2	7720707
Pubmed	STAT5A and STAT5B have opposite correlations with drug response gene expression.	STAT5A STAT5B	5.23e-06	2	80	2	27264955
Pubmed	Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.	STAT5A STAT5B	5.23e-06	2	80	2	22159083
Pubmed	STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.	STAT5A STAT5B	5.23e-06	2	80	2	20008792
Pubmed	STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.	STAT5A STAT5B	5.23e-06	2	80	2	33199496
Pubmed	FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report.	STAT3 STAT5A	5.23e-06	2	80	2	23243289
Pubmed	The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.	STAT5A STAT5B	5.23e-06	2	80	2	16502315
Pubmed	Stat5: an essential regulator of mast cell biology.	STAT5A STAT5B	5.23e-06	2	80	2	12217382
Pubmed	Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.	STAT5A STAT5B	5.23e-06	2	80	2	31599926
Pubmed	DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.	STAT5A STAT5B	5.23e-06	2	80	2	10594041
Pubmed	Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.	STAT5A STAT5B	5.23e-06	2	80	2	21036145
Pubmed	Aberrantly low STAT3 and STAT5 responses are associated with poor outcome and an inflammatory gene expression signature in pediatric acute myeloid leukemia.	STAT3 STAT5A	5.23e-06	2	80	2	33948920
Pubmed	Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.	STAT5A STAT5B	5.23e-06	2	80	2	10486277
Pubmed	Reciprocal effects of STAT5 and STAT3 in breast cancer.	STAT3 STAT5A	5.23e-06	2	80	2	19491198
Pubmed	Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.	STAT5A STAT5B	5.23e-06	2	80	2	16840779
Pubmed	The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.	STAT5A STAT5B	5.23e-06	2	80	2	15128421
Pubmed	STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.	STAT5A STAT5B	5.23e-06	2	80	2	30377054
Pubmed	Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.	STAT5A STAT5B	5.23e-06	2	80	2	23565285
Pubmed	Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.	STAT5A STAT5B	5.23e-06	2	80	2	32790723
Pubmed	In vivo identification of novel STAT5 target genes.	STAT5A STAT5B	5.23e-06	2	80	2	18492722
Pubmed	Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.	STAT5A STAT5B	5.23e-06	2	80	2	10066807
Pubmed	Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.	STAT5A STAT5B	5.23e-06	2	80	2	10835485
Pubmed	Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.	STAT5A STAT5B	5.23e-06	2	80	2	35464049
Pubmed	Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.	STAT5A STAT5B	5.23e-06	2	80	2	18286195
Pubmed	Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.	STAT5A STAT5B	5.23e-06	2	80	2	23773921
Pubmed	Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.	STAT5A STAT5B	5.23e-06	2	80	2	8631883
Pubmed	Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.	STAT5A STAT5B	5.23e-06	2	80	2	11030348
Pubmed	Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.	STAT5A STAT5B	5.23e-06	2	80	2	24878107
Pubmed	Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.	LOXL3 STAT3	5.23e-06	2	80	2	28065600
Pubmed	Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.	STAT5A STAT5B	5.23e-06	2	80	2	12847485
Pubmed	Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.	STAT5A STAT5B	5.23e-06	2	80	2	12835478
Pubmed	Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.	STAT5A STAT5B	5.23e-06	2	80	2	7568026
Pubmed	Identification of STAT5A and STAT5B target genes in human T cells.	STAT5A STAT5B	5.23e-06	2	80	2	24497979
Pubmed	Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.	STAT5A STAT5B	5.23e-06	2	80	2	17536022
Interaction	NIN interactions	TTC28 AASS PKP4 PIBF1 CCDC51 ZNF598 LUZP1 IQGAP1 CEP55	1.01e-05	359	78	9	int:NIN
Interaction	NINL interactions	TTC28 PKP4 CC2D2A PIBF1 ZNF598 DNMBP IQGAP3 LUZP1 IQGAP1 CEP55	1.05e-05	458	78	10	int:NINL
Interaction	WEE2-AS1 interactions	TTC28 ATAD3A AASS KCTD3 EIF3A STAT5B	4.05e-05	163	78	6	int:WEE2-AS1
Interaction	ZC2HC1C interactions	CCDC102B PIBF1 CCDC88B GFAP GOLGA1	4.31e-05	100	78	5	int:ZC2HC1C
Interaction	DSCAM interactions	STAG1 SPTBN1 RAPGEF4 GFAP STAT3 IQGAP1	5.30e-05	171	78	6	int:DSCAM
Interaction	CEP120 interactions	TTC28 PIBF1 STAT3 LUZP1 CEP55	5.70e-05	106	78	5	int:CEP120
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	KRT28 GJC1 GFAP STAT3 STAT5A STAT5B	1.83e-04	473	80	6	chr17q21
GeneFamily	SH2 domain containing	PLCG2 STAT3 STAT5A STAT5B	1.60e-04	101	49	4	741
GeneFamily	Myosin heavy chains	MYH2 MYH8	7.39e-04	15	49	2	1098
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 WNT5A SPTBN1 ATP10A LUZP1 IQGAP1	4.13e-07	158	80	6	ba9998cbf786c515d30fe42de02c7a246db1b6f9
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 WNT5A SPTBN1 ATP10A LUZP1 IQGAP1	4.13e-07	158	80	6	a2efcc184ef13d81373e3690253ba35f6be09c5f
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 WNT5A SPTBN1 ATP10A LUZP1 IQGAP1	4.13e-07	158	80	6	e52eff2bd1e7e0ce9c278ed5109802865e0fe69c
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 SETX SPTBN1 EIF3A UVRAG IQGAP1	1.01e-06	184	80	6	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Brain_organoid-organoid_Tanaka_cellReport\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	ZNF106 MYH8 DGCR6 WNT5A EIF3A IQGAP1	1.64e-06	200	80	6	b0ba486b55be18a4236bd2644f02352651f4b1fe
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	GMNC RAPGEF4 CC2D2A FAM227A AK9	9.45e-06	157	80	5	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	droplet-Heart-4Chambers-21m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG8 HMCN1 RAPGEF4 PLCG2 CCDC51	1.43e-05	171	80	5	e852d0e8589eecf4a2e5fea039b52a67c5d58dbd
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	MEST WNT5A GJC1 IL1A IQGAP3	1.55e-05	174	80	5	fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEST HMCN1 RAPGEF4 GJC1 TMPRSS5	1.64e-05	176	80	5	c4d9166e5bbb7ca544107db14e4374289f5de6bd
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEST HMCN1 RAPGEF4 GJC1 TMPRSS5	1.64e-05	176	80	5	d58ef51002ea50b3037636038214bbb7454cb503
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	SETX HMCN1 STAG1 MAP3K1 LUZP1	2.14e-05	186	80	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Control-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	PLCG2 STX7 DNMBP UVRAG TSPAN33	2.20e-05	187	80	5	4e64be635f445276e71f2937f33f041c3a4204ab
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TTC28 CCDC102B ATP10A TRIP10 STAT3	2.37e-05	190	80	5	0fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLCG2 DNMBP UVRAG MAP3K1 IQGAP1	2.68e-05	195	80	5	481989d2e5bd2582da3d86b0155c4d6615317067
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLCG2 DNMBP UVRAG MAP3K1 IQGAP1	2.68e-05	195	80	5	6108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 RAPGEF4 FRYL KLHL32 IQGAP1	2.68e-05	195	80	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 RAPGEF4 FRYL KLHL32 IQGAP1	2.68e-05	195	80	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 LAMA3 PDIA3 MAP3K1 IQGAP1	2.96e-05	199	80	5	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SETX PKP4 SPTBN1 RAPGEF4 LUZP1	3.03e-05	200	80	5	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SETX HMCN1 PKP4 SPTBN1 RAPGEF4	3.03e-05	200	80	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SETX PKP4 SPTBN1 RAPGEF4 LUZP1	3.03e-05	200	80	5	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnr.Rps24_(Rps24)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYH8 MSH4 IQGAP3 ITIH1	3.32e-05	101	80	4	c075aa59acf333b05b6533b8172dc0c5c31b6ed3
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnr.Rps24_(Rps24)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYH8 MSH4 IQGAP3 ITIH1	3.32e-05	101	80	4	be1c3034c2ebe64b7dd7a9b31ea43336ea1eeb73
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tnr\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYH8 MSH4 IQGAP3 ITIH1	3.32e-05	101	80	4	8ce6ebda05081dbd7db891e5da8af9cc7d4beacb
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYH8 TMPRSS5 MSH4 ITIH1	3.32e-05	101	80	4	a5a3a79f7a61dd4528615c3abaced1c176fd137a
ToppCell	LPS-antiTNF-Unknown-Endothelial-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GJC1 CCDC102B IQGAP3 CEP55	9.42e-05	132	80	4	02491930097b75aaeedab9e8200711b0dc610944
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CD3G ZSCAN4 WNT5A KCTD3	1.39e-04	146	80	4	bb7bf20245d93c8812920dd0debbf1ed00add378
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GABPB2 TTC14 ZNF598 KLHL32	1.71e-04	154	80	4	ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-cDC1\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLCG2 IL1A CCDC88B TSPAN33	1.88e-04	158	80	4	78a8a498a9c84ed65e0eefaac781d5247c5b477a
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3\|TCGA-Skin / Sample_Type by Project: Shred V9	FEM1B ZNF106 HMCN1 TTC28	1.93e-04	159	80	4	fb222c42f66901852b01cec073ec0732245ee973
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATAD3A LOXL3 ITIH1 TSPAN33	1.93e-04	159	80	4	1dde4d19cc0fde7ebbccb4c31bb845a92206021b
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD3G FAM227A PIBF1 ATP10A	1.97e-04	160	80	4	55f599df6e3b7a5a505df4b094c834281311d94a
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD3G FAM227A PIBF1 ATP10A	1.97e-04	160	80	4	296e53e1e0786346d38db2d4188b9a1c0430627b
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCDC51 CCDC88B IQGAP3 STAT5A	2.38e-04	168	80	4	4c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCell	Ionocyte-iono-1\|World / Class top	RAPGEF4 CC2D2A PLCG2 IQGAP1	2.43e-04	169	80	4	4b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCell	control-dn_T\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BCL9L CD3G GABPB2 SPTBN1	2.49e-04	170	80	4	839f62860b4a52d06e6a8fce7632195c7310b89d
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HMCN1 RAPGEF4 GJC1 CCDC102B	2.54e-04	171	80	4	a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GJC1 ATP10A IQGAP3 CEP55	2.54e-04	171	80	4	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GJC1 ATP10A IQGAP3 CEP55	2.54e-04	171	80	4	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SETX RAPGEF4 PLCG2 DNMBP	2.66e-04	173	80	4	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	Ionocyte-iono-2\|World / Class top	PLCG2 IL1A DNMBP IQGAP1	2.66e-04	173	80	4	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CC2D2A ATP10A IQGAP3 CEP55	2.72e-04	174	80	4	72df66319f6efbd88ecf439013d97409fbf3cb52
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CC2D2A ATP10A IQGAP3 CEP55	2.72e-04	174	80	4	c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKP4 TMPRSS5 IQGAP3 CEP55	2.78e-04	175	80	4	9142ed8ca2f1c0c518deb21988221406f62fe38c
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 HMCN1 STAG1 PIBF1	2.84e-04	176	80	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GMNC FAM227A AK9 KLHL32	2.84e-04	176	80	4	dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	PLCG2 STX7 MAP3K1 TSPAN33	2.84e-04	176	80	4	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DGCR6 ATAD3A PKP4 CCDC102B	2.96e-04	178	80	4	9d575902d3dbe33437c9d4200df093a741269803
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	GJC1 LAMA3 CCDC102B ATP10A	3.16e-04	181	80	4	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	VE-matDC\|VE / Condition, Cell_class and T cell subcluster	WNT5A IL1A TRIP10 TSPAN33	3.16e-04	181	80	4	982fd96ef75bc9ab2c2f4970c01b76ba7a164871
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLCG2 STX7 MAP3K1 TSPAN33	3.16e-04	181	80	4	0bc58c8942491e7ee5b858c5742770df7677532f
ToppCell	VE-matDC-\|VE / Condition, Cell_class and T cell subcluster	WNT5A IL1A TRIP10 TSPAN33	3.16e-04	181	80	4	6252184ef098b911df50be4fe1b5565849a5b6b8
ToppCell	COPD-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	TRIP10 UVRAG ITIH1 TSPAN33	3.16e-04	181	80	4	675603a401d92cf9fdcd44e211ec899fa86a0d49
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	GJC1 LAMA3 CCDC102B ATP10A	3.22e-04	182	80	4	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MEST HMCN1 LAMA3 IQGAP1	3.22e-04	182	80	4	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	pdx-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CCDC170 ZNF462 ATP10A IQGAP1	3.22e-04	182	80	4	7b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD3G SPTBN1 GPX7 CEP55	3.22e-04	182	80	4	6c9a48037fa002bc528875538bdaaf15696d68b6
ToppCell	COPD-Stromal-Pericyte\|COPD / Disease state, Lineage and Cell class	MEST AASS GJC1 CCDC102B	3.36e-04	184	80	4	a56264a22dfc2d3672b20134ab7c3c7c23da5ae1
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ZNF106 HMCN1 TTC28 STAT3	3.36e-04	184	80	4	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 SPTBN1 LUZP1 IQGAP1	3.43e-04	185	80	4	7f46ea82a663181957f88e4e83114aef8a78820c
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 SPTBN1 LUZP1 IQGAP1	3.43e-04	185	80	4	956fb0043c0c3e4e5c4d6f58ff95faf6209c380e
ToppCell	356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	KRT28 LAMA3 IQGAP3 CEP55	3.50e-04	186	80	4	189b75aa98903f1cb65b624524ba6c30df7e42ff
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLCG2 MAP3K1 TSPAN33 IQGAP1	3.50e-04	186	80	4	55b239834b96b1f7787ec77a7d19796d617bbbf0
ToppCell	normal_Lung-Myeloid_cells-Activated_DCs\|normal_Lung / Location, Cell class and cell subclass	TRIP10 UVRAG ITIH1 TSPAN33	3.50e-04	186	80	4	0987c9a39503eb6c75a2bf4db98b2b2fd46956fb
ToppCell	COPD-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	MEST AASS GJC1 CCDC102B	3.50e-04	186	80	4	8adfd2d1fda4e8aecc95192ea627bf7ed5214b8d
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 SPTBN1 LUZP1 IQGAP1	3.50e-04	186	80	4	a58c9d1567da0961e0e295a156773d2252ee5a1a
ToppCell	356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|356C / Donor, Lineage, Cell class and subclass (all cells)	KRT28 LAMA3 IQGAP3 CEP55	3.50e-04	186	80	4	261891d0b148e285339ae0b9e36136ceabd9b6f5
ToppCell	droplet-Pancreas-Exocrine-24m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 GPX7 GJC1 LAMA3	3.57e-04	187	80	4	a178b1fed80a0bf83aedb6262493ee17374734b5
ToppCell	droplet-Pancreas-Exocrine-24m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 GPX7 GJC1 LAMA3	3.57e-04	187	80	4	e60cbccf5842f25123fd34b9475759b7424b32e9
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	PLCG2 STX7 DNMBP UVRAG	3.57e-04	187	80	4	af1327559f7e01bec070881cae52834917c3da65
ToppCell	droplet-Pancreas-Exocrine-24m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 GPX7 GJC1 LAMA3	3.57e-04	187	80	4	2b8eda2812be0be68a6f01aa4038925d3d5b1e65
ToppCell	COPD-Myeloid-DC_Mature\|COPD / Disease state, Lineage and Cell class	TRIP10 UVRAG ITIH1 TSPAN33	3.64e-04	188	80	4	de93ccb53edb8599da9e312db0e3af604c21f673
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TTC28 SPTBN1 RAPGEF4 FRYL	3.64e-04	188	80	4	117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCell	MS-CD8-CD4_Treg\|MS / Condition, Cell_class and T cell subcluster	MEST ZNF106 STAG1 PKP4	3.64e-04	188	80	4	2f0e2c7d79ee2d69a5d908c0247dc950c056c30a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD3G CYP4A11 DGCR6L MAP3K1	3.72e-04	189	80	4	284f39dfacec76004daae9dd5317fb7b1f04fa99
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BCL9L CD3G SPTBN1 TTC14	3.72e-04	189	80	4	e9df7ecd36bee1fedce23bb188c68a94fa60462c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLCG2 STX7 UVRAG TSPAN33	3.72e-04	189	80	4	2b53dae0e6e85b7139f8a9872fbebb3705b2f1bf
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	PLCG2 STX7 UVRAG TSPAN33	3.72e-04	189	80	4	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CCDC170 FAM227A AK9 KLHL32	3.72e-04	189	80	4	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-erythrocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC170 CD3G TSPAN33	3.74e-04	78	80	3	c3360f02624a84930f8b44e12bb6b9aa8284ddc7
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATAD3A CC2D2A PIBF1 IQGAP1	3.79e-04	190	80	4	36e83995021ba16690f84e2077a9e8baec547d05
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD3G SPTBN1 MAP3K1 STAT5B	3.79e-04	190	80	4	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF4 GJC1 IQGAP3 CEP55	3.79e-04	190	80	4	31de1727822e9818652946dfb962daee77ffad68
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMCN1 WNT5A SPTBN1 EIF3A	3.79e-04	190	80	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	ZNF106 HMCN1 SPTBN1 CCDC102B	3.79e-04	190	80	4	71e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATAD3A CC2D2A PIBF1 IQGAP1	3.79e-04	190	80	4	d26be9e1b676f750e716b91ebc3598fac3735612
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	PLCG2 DNMBP UVRAG TSPAN33	3.79e-04	190	80	4	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PKP4 SPTBN1 RAPGEF4 PLCG2	3.87e-04	191	80	4	2f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TTC28 SPTBN1 RAPGEF4 PLCG2	3.95e-04	192	80	4	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	COPD-Myeloid-DC_Mature\|Myeloid / Disease state, Lineage and Cell class	TRIP10 UVRAG ITIH1 TSPAN33	3.95e-04	192	80	4	baebd462f464e7d0e462d07a74bb5d685a9fc3b6
ToppCell	B_cells-Memory_B_cells\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	PLCG2 STX7 MAP3K1 TSPAN33	3.95e-04	192	80	4	eef591095921ede098f41a2b81897b18915bb753
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CCDC170 FAM227A AK9 KLHL32	4.02e-04	193	80	4	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CCDC170 FAM227A AK9 KLHL32	4.02e-04	193	80	4	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLCG2 STX7 UVRAG TSPAN33	4.02e-04	193	80	4	6e6c5ae39ea880ba809019a7d39f50e4e02007ed
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLCG2 STX7 UVRAG TSPAN33	4.02e-04	193	80	4	c04ac5884be4245b75d211046f04d76ae0cfb998
ToppCell	B_cells-Activate_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PLCG2 STX7 UVRAG MAP3K1	4.02e-04	193	80	4	b6da81920cf2e55f87ec8d4b2b5530cbf7ba2155
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Plin3_(Plin3)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KRT28 TMPRSS5 ITIH1	4.03e-04	80	80	3	0d5770c81a223148e57d625ac2c2ae69ab55b36e
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Plin3_(Plin3)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KRT28 TMPRSS5 ITIH1	4.03e-04	80	80	3	413796630e7aeff7c68a69dd2d9b8cd8f56163b4
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PLCG2 STX7 UVRAG MAP3K1	4.10e-04	194	80	4	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	control-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PLCG2 STX7 UVRAG TSPAN33	4.10e-04	194	80	4	a5284adca931a78b1c4592925c4860853ebd24f1
Drug	AZD 1480	STAT3 STAT5A STAT5B	1.60e-07	4	79	3	ctd:C545606
Drug	2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide	STAT3 STAT5A STAT5B	4.74e-06	10	79	3	ctd:C585912
Drug	Nor-MDP	IL1A STAT3 STAT5A	1.12e-05	13	79	3	CID000124876
Drug	B202	DGCR6 DGCR6L	1.19e-05	2	79	2	CID006435965
Disease	T-Cell Large Granular Lymphocyte Leukemia	STAT3 STAT5B	6.72e-06	2	77	2	C1955861
Disease	colon adenocarcinoma (is_implicated_in)	STAT3 STAT5A STAT5B	4.25e-05	26	77	3	DOID:234 (is_implicated_in)
Disease	proline measurement, amino acid measurement	DGCR6 DGCR6L	6.69e-05	5	77	2	EFO_0005134, EFO_0009773
Disease	neuroimaging measurement	ZNF462 GMNC ZNF106 STAG1 SPTBN1 GJC1 CC2D2A FRYL GFAP MAP3K1 LUZP1	1.00e-04	1069	77	11	EFO_0004346
Disease	Bell's palsy	MAGED4 CC2D2A LOXL3 LUZP1	1.50e-04	102	77	4	EFO_0007167
Disease	Combined immunodeficiency	CD3G STAT5A STAT5B	1.70e-04	41	77	3	C0494261
Disease	immunoglobulin isotype switching measurement	LAMA3 ITIH1 STAT3	2.10e-04	44	77	3	EFO_0010128
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH2 MYH8	2.98e-04	10	77	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH2 MYH8	2.98e-04	10	77	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH2 MYH8	2.98e-04	10	77	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH2 MYH8	2.98e-04	10	77	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH2 MYH8	2.98e-04	10	77	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH2 MYH8	2.98e-04	10	77	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH2 MYH8	2.98e-04	10	77	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH2 MYH8	2.98e-04	10	77	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH2 MYH8	4.36e-04	12	77	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH2 MYH8	4.36e-04	12	77	2	DOID:2106 (implicated_via_orthology)
Disease	velocity of sound measurement	CCDC170 SPTBN1	5.15e-04	13	77	2	EFO_0005654
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH2 MYH8	5.15e-04	13	77	2	DOID:397 (implicated_via_orthology)
Disease	Meckel-Gruber syndrome	CC2D2A CEP55	6.90e-04	15	77	2	C0265215
Disease	distal arthrogryposis (implicated_via_orthology)	MYH2 MYH8	6.90e-04	15	77	2	DOID:0050646 (implicated_via_orthology)
Disease	T-Cell Lymphoma	STAT3 STAT5B	7.88e-04	16	77	2	C0079772
Disease	Usual Interstitial Pneumonia	WNT5A STAT3	1.12e-03	19	77	2	C4721509
Disease	Hamman-Rich Disease	WNT5A STAT3	1.12e-03	19	77	2	C4721508
Disease	Familial Idiopathic Pulmonary Fibrosis	WNT5A STAT3	1.24e-03	20	77	2	C4721952
Disease	Idiopathic Pulmonary Fibrosis	WNT5A STAT3	1.37e-03	21	77	2	C1800706
Disease	proline measurement	DGCR6 DGCR6L	2.10e-03	26	77	2	EFO_0009773
Disease	myocardial infarction	STAG1 PLCG2 CCDC102B DNMBP STAT3	2.24e-03	350	77	5	EFO_0000612
Disease	Fever	IL1A STAT3	2.26e-03	27	77	2	C0015967
Disease	gastric adenocarcinoma (is_marker_for)	STAT5A STAT5B	2.43e-03	28	77	2	DOID:3717 (is_marker_for)
Disease	Weight Gain	MEST SPTBN1 IQGAP1	2.44e-03	102	77	3	C0043094

Protein segments in the cluster

Peptide	Gene	Start	Entry
NRRLQHQQLYYSQDD	PKP4	1106	Q99569
ELQNNLFDRIAQHYA	FAM227A	211	F5H4B4
REDDQYSHLQGNQLR	CD3G	166	P09693
SQHQRYQGLEQRLEA	CCDC88B	911	A6NC98
TRQHQARAQYQDKLA	ATAD3A	171	Q9NVI7
HNYRNSSQAVQAVRD	AASS	186	Q9UDR5
VHNLNQLLYSQRRAD	CEP55	276	Q53EZ4
NLVFSRVRNAFHQND	CYP4A11	226	Q02928
RVRNAFHQNDTIYSL	CYP4A11	231	Q02928
QSARNNYEALNAQLL	DNMBP	1151	Q6XZF7
RQQERHYQLLSALQS	DGCR6	16	Q14129
AHEQNQVLNTNSRYL	PHYKPL	71	Q8IUZ5
HDANAQRLARYQEAD	ATP10A	451	O60312
DAANSAAQQYQRRLA	IQGAP1	376	P46940
RANDQYLTAAALHNL	IL1A	146	P01583
QNLNDRLASYLDNVR	KRT28	91	Q7Z3Y7
NAAFYRLLAQRQQHS	LOXL3	226	P58215
GELRNLVSLHAYNNQ	LRRD1	671	A4D1F6
HQYILNSNRANRRAT	MAGED4	681	Q96JG8
RNEYERSLQNHQFEL	GOLGA1	451	Q92805
RNQLLNYRSAISNHG	LAMA3	1871	Q16787
NNGRAQRIYEDHDAT	ITIH1	451	P19827
AARAVRANDINYQDQ	FEM1B	601	Q9UK73
NRLAAESLRNYRNTQ	MYH8	1636	P13535
NHANRMAAEALRNYR	MYH2	1636	Q9UKX2
TLNIYQNLNRRQHEH	PDE6B	641	P35913
LDRYSDRNMQINRHQ	FRYL	1091	O94915
VSNFSRIYHQNQRAD	KCND2	406	Q9NZV8
NNQLFLYDTHQNLRN	PLCG2	1211	P16885
LYDTHQNLRNANRDA	PLCG2	1216	P16885
RQAKHEANDYRRQLQ	GFAP	276	P14136
ANARNHDDRESQDIY	IQGAP3	261	Q86VI3
GHLLNVDQNQNSYRL	HMCN1	3841	Q96RW7
LAQLYDQYLARHQRN	CC2D2A	431	Q9P2K1
NNSRVERLYHDIAQQ	EIF3A	166	Q14152
QERLDLAVQAYSHQN	GJC1	346	P36383
LQGRADSILAYHQQN	BCL9L	256	Q86UU0
RQQERHYQLLSALQS	DGCR6L	16	Q9BY27
RLRNREFALNNENYS	LUZP1	401	Q86V48
TREQLNHYRNVAQNA	CCDC170	31	Q8IYT3
NHYRNVAQNARSELA	CCDC170	36	Q8IYT3
DQHYRALQQLQRDLG	GPX7	61	Q96SL4
RYCNLNHFNAQNIRG	SLC15A5	531	A6NIM6
QYQANIAELTHANNR	CCDC102B	436	Q68D86
HSYRDFQTINLNRNV	KCTD3	666	Q9Y597
LQNRRINLLSHDYGD	MEST	136	Q5EB52
QSERLQRQLQQEHAY	MINK1	461	Q8N4C8
SRRNQESNFNLTHYG	MAP3K1	531	Q13233
NQLAQALRVYSQHAR	SMG8	526	Q8ND04
LQEANRRAQEYRHQL	GABPB2	361	Q8TAK5
DYDLCQRISGQRQHN	AK9	151	Q5TCS8
RNIVNRNGHQLLDTY	UVRAG	51	Q9P2Y5
ANKNHQDVRSYVRQL	RAPGEF4	976	Q8WZA2
EENNHLRQYLNSALV	GMNC	106	A6NCL1
QASSYSRQQRDLHNL	CCDC51	251	Q96ER9
HVQQANQQLSRAADY	STX7	216	O15400
SNLRDNYRFAHTNVE	PDIA3	176	P30101
YSRQQNRFNDFDHRE	SLTM	761	Q9NWH9
QTIINNASYNREIRH	SETX	316	Q7Z333
SRSLENAVNRIYHDQ	SPATA16	6	Q9BXB7
HILYNEQRLVREANN	STAT5B	111	P51692
ELLINNQDYRNNHTL	MSH4	321	O15457
EYQRQQLLADRQAFH	SMARCC2	921	Q8TAQ2
RQLQEDAARLQAAYA	SPTBN1	1861	Q01082
HILYNEQRLVREANN	STAT5A	111	P42229
AAQLQRFNRDQAHFY	TRIP10	191	Q15642
HRNNKNRNAENASYI	C12orf50	321	Q8NA57
NRNAENASYIHVQRD	C12orf50	326	Q8NA57
NNAIVHYRDDLDLQN	TSPAN33	131	Q86UF1
FRLALVNNNNHAEAY	TTC8	446	Q8TAM2
SDQDAHQYLRLRDQS	TSPYL1	26	Q9H0U9
FLQESNVLYQHNLRR	STAT3	71	P40763
LQAQNSEHQARLDIY	PIBF1	516	Q8WXW3
DLRSYQRLHQHNLQN	TLE7	316	A0A1W2PR48
SAQNHDYDVALLRLQ	TMPRSS5	301	Q9H3S3
SIHQDNTQRQYEAER	STAG1	241	Q8WVM7
FSRHEQRYRLNTNQG	TTC14	696	Q96N46
HNNEAGRRTVYNLAD	WNT5A	221	P41221
QDSNNSYARQELQRL	ZSCAN4	51	Q8NAM6
EARQNRHIDLQFSYA	ZNF598	276	Q86UK7
DRALQHYQNHLNIAR	TTC28	571	Q96AY4
LNHYQSAALARNNSR	ZNF462	2156	Q96JM2
DNNLLQARAALQTAY	ZNF106	1071	Q9H2Y7
GNDLDYNNDRILVRH	KLHL32	501	Q96NJ5