Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessGPI anchor biosynthetic process

PIGO PIGM

2.47e-053352GO:0006506
GeneOntologyBiologicalProcessGPI anchor metabolic process

PIGO PIGM

2.79e-053552GO:0006505
GeneOntologyBiologicalProcessglycolipid biosynthetic process

PIGO PIGM

1.51e-048152GO:0009247
GeneOntologyBiologicalProcessprotein lipidation

PIGO PIGM

2.35e-0410152GO:0006497
GeneOntologyBiologicalProcesslipoprotein biosynthetic process

PIGO PIGM

2.59e-0410652GO:0042158
GeneOntologyBiologicalProcessglycolipid metabolic process

PIGO PIGM

3.26e-0411952GO:0006664
GeneOntologyBiologicalProcessliposaccharide metabolic process

PIGO PIGM

3.32e-0412052GO:1903509
GeneOntologyBiologicalProcessphosphatidylinositol biosynthetic process

PIGO PIGM

4.01e-0413252GO:0006661
GeneOntologyBiologicalProcesslipoprotein metabolic process

PIGO PIGM

4.97e-0414752GO:0042157
GeneOntologyBiologicalProcessmembrane lipid biosynthetic process

PIGO PIGM

5.67e-0415752GO:0046467
GeneOntologyBiologicalProcessphosphatidylinositol metabolic process

PIGO PIGM

6.64e-0417052GO:0046488
GeneOntologyBiologicalProcessglycerophospholipid biosynthetic process

PIGO PIGM

1.08e-0321752GO:0046474
GeneOntologyBiologicalProcessmembrane lipid metabolic process

PIGO PIGM

1.20e-0322952GO:0006643
GeneOntologyBiologicalProcessglycerolipid biosynthetic process

PIGO PIGM

1.64e-0326852GO:0045017
GeneOntologyBiologicalProcessphospholipid biosynthetic process

PIGO PIGM

1.64e-0326852GO:0008654
GeneOntologyBiologicalProcessglycerophospholipid metabolic process

PIGO PIGM

2.33e-0332052GO:0006650
GeneOntologyBiologicalProcessphospholipid metabolic process

PIGO PIGM

3.79e-0341052GO:0006644
GeneOntologyBiologicalProcessglycerolipid metabolic process

PIGO PIGM

4.14e-0342952GO:0046486
GeneOntologyBiologicalProcessorganophosphate biosynthetic process

PIGO PIGM

9.14e-0364452GO:0090407
GeneOntologyBiologicalProcesscarbohydrate derivative biosynthetic process

PIGO PIGM

1.18e-0273652GO:1901137
GeneOntologyBiologicalProcesslipid biosynthetic process

PIGO PIGM

1.43e-0281352GO:0008610
GeneOntologyCellularComponentleading edge membrane

GABBR1 ITGA5

9.85e-0421052GO:0031256
GeneOntologyCellularComponentendoplasmic reticulum membrane

PIGO GABBR1 PIGM

2.15e-03129353GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

PIGO GABBR1 PIGM

2.18e-03129953GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

PIGO GABBR1 PIGM

2.32e-03132753GO:0042175
GeneOntologyCellularComponentplasma membrane signaling receptor complex

GABBR1 ITGA5

2.70e-0335052GO:0098802
GeneOntologyCellularComponentpostsynaptic membrane

GABBR1 ITGA5

3.60e-0340552GO:0045211
GeneOntologyCellularComponentcell projection membrane

GABBR1 ITGA5

4.07e-0343152GO:0031253
GeneOntologyCellularComponentcell leading edge

GABBR1 ITGA5

5.44e-0350052GO:0031252
GeneOntologyCellularComponentreceptor complex

GABBR1 ITGA5

7.29e-0358152GO:0043235
GeneOntologyCellularComponentsynaptic membrane

GABBR1 ITGA5

7.34e-0358352GO:0097060
GeneOntologyCellularComponentplasma membrane protein complex

GABBR1 ITGA5

1.31e-0278552GO:0098797
GeneOntologyCellularComponentglutamatergic synapse

GABBR1 ITGA5

1.41e-0281752GO:0098978
GeneOntologyCellularComponentmitochondrial membrane

GABBR1 YME1L1

1.58e-0286652GO:0031966
GeneOntologyCellularComponentmitochondrial envelope

GABBR1 YME1L1

1.74e-0291252GO:0005740
GeneOntologyCellularComponentpostsynapse

GABBR1 ITGA5

2.15e-02101852GO:0098794
PathwayREACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI

PIGO PIGM

1.54e-051852M1093
PathwayKEGG_MEDICUS_REFERENCE_GPI_ANCHOR_BIOSYNTHESIS

PIGO PIGM

2.77e-052452M47625
PathwayKEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS

PIGO PIGM

3.01e-052552M13265
PathwayREACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS

PIGO PIGM

4.25e-049352M26985
PathwayREACTOME_SIGNALING_BY_GPCR

GABBR1 ITGA5

1.91e-0264652MM14962
Pubmed

Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.

PIGO PIGM

2.25e-06175211102867
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

GABBR1 PIGM ITGA5

7.78e-056975328298427
InteractionKLRC3 interactions

PIGO PIGM

1.99e-052952int:KLRC3
InteractionOR4N2 interactions

PIGO PIGM

1.99e-052952int:OR4N2
InteractionGABRE interactions

PIGO PIGM

6.00e-055052int:GABRE
InteractionHTR3C interactions

PIGO PIGM

1.87e-048852int:HTR3C
InteractionPTH1R interactions

PIGO PIGM

1.87e-048852int:PTH1R
InteractionADGRG5 interactions

PIGO PIGM

2.09e-049352int:ADGRG5
InteractionGRK6 interactions

YME1L1 ITGA5

4.79e-0414152int:GRK6
InteractionUPK1A interactions

PIGO PIGM

5.42e-0415052int:UPK1A
InteractionC5AR1 interactions

PIGO PIGM

5.71e-0415452int:C5AR1
InteractionSLC39A4 interactions

PIGO YME1L1

6.40e-0416352int:SLC39A4
InteractionTMEM106A interactions

PIGO ITGA5

1.10e-0321452int:TMEM106A
InteractionATP1B3 interactions

PIGO ITGA5

1.28e-0323152int:ATP1B3
InteractionATP2A3 interactions

PIGO YME1L1

1.29e-0323252int:ATP2A3
InteractionSPPL2B interactions

PIGO PIGM

1.30e-0323352int:SPPL2B
InteractionCMTM5 interactions

PIGO PIGM

1.37e-0323952int:CMTM5
InteractionTTYH1 interactions

PIGO PIGM

2.14e-0330052int:TTYH1
InteractionTMEM106B interactions

PIGO ITGA5

2.27e-0330952int:TMEM106B
GeneFamilyGlycosyl transferases group 1 domain containing|Phosphatidylinositol glycan anchor biosynthesis

PIGO PIGM

1.28e-052152680
CoexpressionPKCA_DN.V1_DN

PIGO GABBR1

3.39e-0415452M2754
CoexpressionRAPA_EARLY_UP.V1_UP

PIGO ITGA5

3.98e-0416752M2644
CoexpressionGSE3920_UNTREATED_VS_IFNG_TREATED_FIBROBLAST_DN

GABBR1 ITGA5

4.58e-0417952M6689
CoexpressionGSE37301_PRO_BCELL_VS_RAG2_KO_NK_CELL_UP

GABBR1 PIGM

4.73e-0418252M8899
CoexpressionGSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_LOWDOSE_STIM_DC_DN

GABBR1 ITGA5

5.54e-0419752M8611
CoexpressionGSE5542_UNTREATED_VS_IFNA_TREATED_EPITHELIAL_CELLS_6H_DN

GABBR1 PIGM

5.59e-0419852M6516
CoexpressionHALLMARK_INFLAMMATORY_RESPONSE

GABBR1 ITGA5

5.71e-0420052M5932
CoexpressionGSE21670_STAT3_KO_VS_WT_CD4_TCELL_TGFB_IL6_TREATED_DN

GABBR1 ITGA5

5.71e-0420052M7453
CoexpressionGSE15330_HSC_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_IKAROS_KO_UP

GABBR1 PIGM

5.71e-0420052M7022
CoexpressionGSE2405_S_AUREUS_VS_A_PHAGOCYTOPHILUM_NEUTROPHIL_DN

PIGO GABBR1

5.71e-0420052M6208
CoexpressionGSE16385_UNTREATED_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_UP

PIGM ITGA5

5.71e-0420052M7911
CoexpressionJINESH_BLEBBISHIELD_VS_LIVE_CONTROL_DN

GABBR1 PIGM

1.19e-0328952M38973
CoexpressionMILI_PSEUDOPODIA_CHEMOTAXIS_DN

PIGM ITGA5

2.93e-0345752M1613
CoexpressionDELACROIX_RAR_BOUND_ES

GABBR1 ITGA5

3.03e-0346552M2466
CoexpressionMILI_PSEUDOPODIA_CHEMOTAXIS_DN

PIGM ITGA5

3.10e-0347052MM1053
CoexpressionDELACROIX_RAR_BOUND_ES

GABBR1 ITGA5

3.40e-0349352MM1079
CoexpressionWAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D

PIGM ITGA5

5.77e-0364652M2419
CoexpressionWAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D

PIGM ITGA5

6.29e-0367552MM1073
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

PIGO ITGA5

6.40e-0368152M5314
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

PIGO ITGA5

6.81e-0370352MM1055
CoexpressionMARSON_BOUND_BY_E2F4_UNSTIMULATED

YME1L1 PIGM

7.02e-0371452M1744
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN

PIGO ITGA5

8.25e-0377652M1107
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN

PIGO ITGA5

8.62e-0379452MM982
CoexpressionBLALOCK_ALZHEIMERS_DISEASE_DN

GABBR1 YME1L1

2.06e-02124852M17728
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GABBR1 ITGA5

1.63e-0418352858682df5592c6856487487a7baabd6e60e63a38
ToppCell3'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GABBR1 ITGA5

1.63e-0418352f8212bf8a8b8312434ae030261c558c147f61747
DrugAC1NDOB4

PIGO PIGM

9.74e-062352CID004629010
DrugNSC35456

PIGO PIGM

3.81e-054552CID000006725
DrugAC1L96SZ

PIGO PIGM

4.71e-055052CID000439166
DrugDiazepam

GABBR1 ITGA5

1.04e-047452ctd:D003975
DrugIsocorydine (+) [475-67-2]; Up 200; 11.8uM; MCF7; HT_HG-U133A

PIGO ITGA5

7.10e-04194522780_UP
DrugMebeverine hydrochloride [2753-45-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A

PIGO ITGA5

7.10e-04194523193_DN
DrugPiribedil hydrochloride [78213-63-5]; Down 200; 12uM; MCF7; HT_HG-U133A

PIGO ITGA5

7.18e-04195523512_DN
Drugtroglitazone; Down 200; 10uM; MCF7; HT_HG-U133A

PIGO ITGA5

7.18e-04195521657_DN
Drugmonastrol; Up 200; 100uM; MCF7; HG-U133A

PIGO ITGA5

7.18e-0419552596_UP
DrugAcenocoumarol [152-72-7]; Up 200; 11.4uM; HL60; HG-U133A

PIGO YME1L1

7.32e-04197521394_UP
Drugthioridazine hydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A

PIGO ITGA5

7.32e-04197525227_DN
DrugAmitryptiline hydrochloride [549-18-8]; Down 200; 12.8uM; MCF7; HT_HG-U133A

PIGO ITGA5

7.40e-04198521701_DN
DrugAlthiazide [5588-16-9]; Down 200; 10.4uM; MCF7; HT_HG-U133A

PIGO ITGA5

7.40e-04198526089_DN
DrugGuanabenz acetate [23256-50-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

PIGO ITGA5

7.40e-04198525703_DN
DrugLevopropoxyphene napsylate [5714-90-9]; Down 200; 7.4uM; MCF7; HT_HG-U133A

PIGO ITGA5

7.47e-04199523543_DN

Protein segments in the cluster

PeptideGeneStartEntry
YKGLLLLLGIFLAYE

GABBR1

776

Q9UBS5
ILFGLLLLGLLIYIL

ITGA5

1006

P08648
LLLGLLIYILYKLGF

ITGA5

1011

P08648
ILFVLLLFGIYGLLK

YME1L1

296

Q96TA2
YAALLQLGLKYLFIL

PIGO

1006

Q8TEQ8
TAFLLYRLLLLKGLG

PIGM

106

Q9H3S5