Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvolume-sensitive anion channel activity

LRRC8E LRRC8A

1.54e-049422GO:0005225
MousePhenofused kidneys

DACT1 CYP26A1

2.85e-054312MP:0003605
MousePhenoabnormal primitive urogenital sinus morphology

DACT1 CYP26A1

4.74e-055312MP:0010116
MousePhenosirenomelia

DACT1 CYP26A1

4.74e-055312MP:0003445
MousePhenoabnormal embryonic cloaca morphology

DACT1 CYP26A1

9.93e-057312MP:0010115
MousePhenoabnormal genital tubercle morphology

DACT1 CYP26A1

9.93e-057312MP:0011771
MousePhenodecreased transitional stage B cell number

LRRC8A PLCG2 BACH2

1.41e-0446313MP:0008190
MousePhenodecreased follicular B cell number

SIGLEC1 PLCG2 BACH2

1.91e-0451313MP:0008174
MousePhenoabnormal hindgut morphology

DACT1 CYP26A1

2.59e-0411312MP:0008786
DomainARM-type_fold

CUL9 TTI1 STK36 NBEA USP35 ATR RNPEPL1

6.80e-06339407IPR016024
DomainARM-like

CUL9 TTI1 STK36 NBEA USP35 ATR

2.19e-05270406IPR011989
DomainLRRC8_Pannexin-like

LRRC8E LRRC8A

4.45e-055402IPR021040
DomainPannexin_like

LRRC8E LRRC8A

4.45e-055402PF12534
DomainHud_Sxl_RNA

CELF1 CELF2

1.99e-0410402IPR002343
DomainPNMA

PNMA5 PNMA6A

2.43e-0411402PF14893
DomainPNMA

PNMA5 PNMA6A

2.43e-0411402IPR026523
DomainSRCR

SSC5D SSC4D

9.15e-0421402PF00530
Domain-

CUL9 TTI1 STK36 ATR

1.27e-032224041.25.10.10
DomainSR

SSC5D SSC4D

1.30e-0325402SM00202
Domain-

SSC5D SSC4D

1.30e-03254023.10.250.10
DomainSRCR_1

SSC5D SSC4D

1.41e-0326402PS00420
DomainSRCR-like_dom

SSC5D SSC4D

1.41e-0326402IPR017448
DomainSRCR_2

SSC5D SSC4D

1.41e-0326402PS50287
DomainSRCR

SSC5D SSC4D

1.52e-0327402IPR001190
DomainPH_dom-like

PLEKHG4B PHLDB3 NBEA FGD5 PLCG2

2.06e-03426405IPR011993
DomainPH

PLEKHG4B PHLDB3 FGD5 PLCG2

2.88e-03278404SM00233
DomainPH_DOMAIN

PLEKHG4B PHLDB3 FGD5 PLCG2

2.92e-03279404PS50003
DomainPH_domain

PLEKHG4B PHLDB3 FGD5 PLCG2

2.96e-03280404IPR001849
DomainZF_RING_1

CUL9 NEURL1B LONRF2 TRIM58

3.39e-03291404PS00518
DomainC2

CPNE6 PLCG2 WWC3

3.46e-03142403PS50004
DomainZF_RING_2

CUL9 NEURL1B LONRF2 TRIM58

3.69e-03298404PS50089
Domain-

CPNE6 PLCG2 WWC3

3.89e-031484032.60.40.150
DomainRING

CUL9 NEURL1B LONRF2 TRIM58

4.01e-03305404SM00184
DomainHEAT

STK36 ATR

4.74e-0348402PF02985
DomainZnf_RING

CUL9 NEURL1B LONRF2 TRIM58

5.08e-03326404IPR001841
DomainZnf_RING_CS

CUL9 LONRF2 TRIM58

5.09e-03163403IPR017907
DomainC2_dom

CPNE6 PLCG2 WWC3

5.18e-03164403IPR000008
DomainHEAT

STK36 ATR

6.85e-0358402IPR000357
Pubmed

Diversity and conservation of CELF1 and CELF2 RNA and protein expression patterns during embryonic development.

CELF1 CELF2

1.42e-06242223468433
Pubmed

LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.

LRRC8E LRRC8A

1.42e-06242233139539
Pubmed

Isolation and expression of Napor/CUG-BP2 in embryo development.

CELF1 CELF2

1.42e-06242212763013
Pubmed

Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.

CELF1 CELF2

1.42e-06242221541285
Pubmed

Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.

CELF2 PTPRN2

4.27e-06342227153397
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CCDC142 LRRC8E PHLDB3 CUL9 DACT1 STK36 ANKLE1 NPHP4 RNPEPL1

5.54e-06110542935748872
Pubmed

LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

LRRC8E LRRC8A

8.53e-06442226824658
Pubmed

Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.

LRRC8E LRRC8A

8.53e-06442228193731
Pubmed

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.

LRRC8E LRRC8A

8.53e-06442233171122
Pubmed

Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.

LRRC8E LRRC8A

1.42e-05542235777784
Pubmed

Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development.

CELF1 CELF2

1.42e-05542215830352
Pubmed

LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.

LRRC8E LRRC8A

1.42e-05542215094057
Pubmed

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

LRRC8E LRRC8A

1.42e-05542224790029
Pubmed

The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease.

PNMA5 PNMA6A

2.13e-05642216214224
Pubmed

The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.

CELF1 CELF2

2.13e-05642211158314
Pubmed

MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1.

CELF1 CELF2

2.13e-05642219720736
Pubmed

A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.

CELF1 CELF2

2.13e-05642210893231
Pubmed

miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification.

CELF1 CELF2

2.98e-05742227512039
Pubmed

The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.

FGD5 SIGLEC1

3.97e-05842235065706
Pubmed

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

TTI1 ATR

3.97e-05842220810650
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

CUL9 NBEA PLCG2 CELF2 PTPRN2

4.69e-0532942517474147
Pubmed

Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators.

CELF1 CELF2

5.10e-05942228763438
Pubmed

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

TTI1 ATR

7.78e-051142220427287
Pubmed

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.

LRRC8E LRRC8A

9.32e-051242232277911
Pubmed

Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.

CELF1 CELF2

1.28e-041442228826478
Pubmed

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

TTI1 ATR

2.40e-041942220801936
Pubmed

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

TTI1 ATR

4.90e-042742223027611
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

CUL9 STK36 PTPRN2

5.27e-0413042312421765
Pubmed

Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4.

EMILIN1 MSLN

9.74e-043842231624071
GeneFamilyVolume regulated anion channel subunits

LRRC8E LRRC8A

2.65e-0553021158
GeneFamilyParaneoplastic Ma antigens

PNMA5 PNMA6A

1.45e-0411302671
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SSC5D SSC4D

9.10e-04273021253
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHG4B PHLDB3 FGD5

4.72e-03206303682
GeneFamilyWD repeat domain containing

NBEA WDR6 RRP9

9.15e-03262303362
ToppCell(5)_Glands_mucous|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

NBEA PTPRN2 PNMA6A MUC5AC MSLN

6.92e-07178425f0f19b0d78f2cc5df4d4c321a953a6e447d5114a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SSC4D TRIM58 LINC02875 MSLN

1.08e-05146424d33bd571c2adf5f89e6f02e77d094c19edd4729c
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SSC5D EMILIN1 LINC02875 BACH2

1.71e-05164424e3983f655cdba308fb192182829f17bef99ce0ba
ToppCellwk_15-18-Mesenchymal-Fibroblast-Mesenchymal_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NBEA SSC4D PNMA6A CYP26A1

2.11e-05173424b43817a6b1ed8d6b5366702343be4311c0d52d83
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))--|Thalamus / BrainAtlas - Mouse McCarroll V32

PNMA5 TRIM58 CYP26A1

2.14e-05574239614fe2acc6ee039383504f94bbe6d35aac27f25
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))-|Thalamus / BrainAtlas - Mouse McCarroll V32

PNMA5 TRIM58 CYP26A1

2.14e-05574233c55a5598a7ea789500f2fbd35c79d2b97a3fc7d
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))|Thalamus / BrainAtlas - Mouse McCarroll V32

PNMA5 TRIM58 CYP26A1

2.14e-0557423309b3d48bfe215d7b581722c06d444b5b2ef6a30
ToppCellAdult-Epithelial-lung_goblet_cell|Adult / Lineage, Cell type, age group and donor

PLEKHG4B NBEA PTPRN2 MUC5AC

2.41e-051794241fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCell(5)_Epithelial_cells-(5)_Glands_mucous|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

NBEA PTPRN2 PNMA6A MUC5AC

2.46e-05180424a4118adaf4b09e2ca01b662ed60e7bbf32a24d58
ToppCellwk_08-11-Mesenchymal-Mesothelial-Late_mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

LRRC8A SSC4D TRIM58 MSLN

2.57e-05182424f8257c884393f168f605d371e0840cfca8d3657e
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRC8A NBEA MUC5AC MSLN

3.50e-05197424d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRC8A NBEA MUC5AC MSLN

3.50e-0519742480b05c8ad9c1edc5dea3236079372475431343fe
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG4B NBEA PTPRN2 MUC5AC

3.57e-05198424af07a970afaa435c6433bb5c1cbff4c67af350c7
ToppCellBronchus_Control_(B.)-Epithelial-TX-Club|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

NBEA PLCG2 MUC5AC MSLN

3.72e-05200424292c63693eb7f435335a8cfba07aa35b72139393
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron|3m / Sample Type, Dataset, Time_group, and Cell type.

DACT1 NBEA CELF2 BACH2

3.72e-05200424c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal|3m / Sample Type, Dataset, Time_group, and Cell type.

DACT1 NBEA CELF2 BACH2

3.72e-05200424af99d90070e2933fd2e9512590c6cf3bd6e15539
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2-Excitatory_Neuron.Slc17a7-Slc17a8.Fezf2-Slc17a8_(Layer_5,_Retrosplenial_cortex_(RSG)_and_Subiculum,_Tshz2+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LRRC8E SIGLEC1 TRIM58

4.31e-0572423e3f4d1df43cc41b0424f27485a00ddca9e905f95
Diseasecommon bile duct neoplasm (is_marker_for)

MUC5AC MSLN

4.74e-058392DOID:4608 (is_marker_for)
DiseaseHypogammaglobulinemia

LRRC8A BACH2

2.29e-0417392C0086438
Diseasereticulocyte measurement

SIGLEC1 PLCG2 ATR RNH1 CELF1 TRIM58 RNPEPL1

4.09e-041053397EFO_0010700
Diseasered blood cell density measurement

STK36 FGD5 ATR TRIM58 RNPEPL1 BACH2

9.73e-04880396EFO_0007978
Diseasereticulocyte count

PLCG2 ATR RNH1 CELF1 TRIM58 RNPEPL1

2.33e-031045396EFO_0007986
Diseaseinformation processing speed, response to cranial radiation therapy

CUL9 SIGLEC1

2.69e-0358392EFO_0004363, EFO_0010950
Diseasepancreatic ductal carcinoma (is_marker_for)

MUC5AC MSLN

2.97e-0361392DOID:3587 (is_marker_for)
Diseasenon-lobar intracerebral hemorrhage

CELF1 PTPRN2

3.16e-0363392EFO_0010178
Diseasethyroid peroxidase antibody measurement

PTPRN2 BACH2

4.10e-0372392EFO_0005666
Diseasewaist-hip ratio

CUL9 SSC5D NEURL1B CELF1 LONRF2 LINC02875

5.12e-031226396EFO_0004343

Protein segments in the cluster

PeptideGeneStartEntry
LRGPGLEALCKQEGE

BACH2

411

Q9BYV9
GQIEECRILRGPDGL

CELF2

156

O95319
LLRCGADPNLVLEDG

ANKLE1

26

Q8NAG6
LRCLGALLRQGGDPN

ANKLE1

56

Q8NAG6
FGQIEECRILRGPDG

CELF1

131

Q92879
RRCQEEGDLLPGLLG

CCDC142

266

Q17RM4
LLDGDDGPLRCPRGV

CPNE6

481

O95741
RQLPGRLGCLLEEGL

PTPRN2

31

Q92932
LRGNRLECLPVELGE

LRRC8A

761

Q8IWT6
RLLELNCLQGTPGGD

PHLDB3

321

Q6NSJ2
NGRLPCVDRGLDEGP

FGD5

36

Q6ZNL6
DVRALGGLACDLPGR

MSLN

181

Q13421
RLEALPEELGNCGGL

LRRC8E

756

Q6NSJ5
AGLAQPDRGLCLRLG

LONRF2

51

Q1L5Z9
NPRGDCLRDVRGLEG

MUC5AC

1191

P98088
EDNPLGSLCRGILDL

PLCG2

841

P16885
GCGPLDGGALEILER

NPHP4

271

O75161
ECLGELGAIDPGRLD

ATR

1356

Q13535
CLTGNPLREEDRLGN

DACT1

286

Q9NYF0
LGREREIDCGPRQAG

LINC02875

206

Q86X59
DLERVLCREGSPGGA

CUL9

966

Q8IWT3
RILLGCEPQLAGDGD

CYP26A1

191

O43174
PSLEGRLGRLEGVCE

EMILIN1

721

Q9Y6C2
LCGRNGGALEELIRE

DHRS7B

81

Q6IAN0
LGLELRPEARELAGC

RNPEPL1

46

Q9HAU8
GDLLRALEGPENCLF

NBEA

2811

Q8NFP9
EGSGPIILDDLRCRG

SSC5D

361

A1L4H1
EGLCRLLGQEPLALE

STK36

726

Q9NRP7
NARRGLLILGIPEDC

PNMA6A

16

P0CW24
ALRGKLELLDQRGCP

PNMA5

301

Q96PV4
GEGFRQLDLLCDIPL

RRP9

406

O43818
GRGPILLDNVECRGQ

SSC4D

116

Q8WTU2
GRGPILLDNVKCRGE

SSC4D

531

Q8WTU2
PRECERGLPEGRGEL

TEX54

36

A0A1B0GVG6
LPGRALLCGQDGETL

PLEKHG4B

656

Q96PX9
GGAEELPRRVGCQLL

USP35

51

Q9P2H5
LGINGRPRGRLLCVD

NEURL1B

396

A8MQ27
LGLCENQEARERPGG

ZNF696

71

Q9H7X3
GDAGLQLLCEGLLDP

RNH1

126

P13489
GPGRLGLLLCRVDSD

SIGLEC1

996

Q9BZZ2
FVEPEGGLRGILDCR

SIGLEC1

1541

Q9BZZ2
GGLRGILDCRVDSEP

SIGLEC1

1546

Q9BZZ2
CVGDRLLAGEGPDVL

WDR6

26

Q9NNW5
DSCEGPGLGALDRLR

WWC3

486

Q9ULE0
LQERCQRPALGLLEG

TRIM58

236

Q8NG06
VLQGLGPLCERLDLG

TTI1

986

O43156
GPLCERLDLGEGDLN

TTI1

991

O43156