Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCA1 LONP2 DYNC2H1 DHX37 SMCHD1 SMC6 ABCF2 CCT4 HELQ DHX8 DNAH12 ABCA5 MCM9 DNAH8

2.78e-0544117114GO:0016887
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DYNC2H1 RILP DNAH12 DNAH8

9.05e-05281714GO:0051959
GeneOntologyMolecularFunctionkinase activity

EPHB3 EPHB6 PRKD2 DDR1 CAD GALK1 RIPK1 ERN2 TRRAP PTK2 AK5 SIK2 NADK PAK2 PPIP5K1 BRSK1 WNK4 MVK

1.02e-0476417118GO:0016301
GeneOntologyMolecularFunctionintegrin binding

FBLN5 VWF ACTN4 ACTN1 ACTN2 ACTN3 PTK2 DST

1.36e-041751718GO:0005178
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

EPHB3 EPHB6 PRKD2 DDR1 CAD GALK1 RIPK1 POLA1 YRDC ERN2 TRRAP PTK2 AK5 SIK2 NADK PAK2 PPIP5K1 BRSK1 WNK4 MVK

1.60e-0493817120GO:0016772
GeneOntologyMolecularFunctionATP-dependent activity

ABCA1 LONP2 DYNC2H1 DHX37 SMCHD1 SMC6 ABCF2 CCT4 HELQ DHX8 DNAH12 ABCA5 MCM9 ATP1B2 DNAH8

2.68e-0461417115GO:0140657
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DYNC2H1 DNAH12 DNAH8

4.58e-04181713GO:0008569
GeneOntologyMolecularFunctioncell adhesion molecule binding

FBLN5 ABI1 VWF DSP CDHR3 ACTN4 ACTN1 ACTN2 ACTN3 LRRC4C PTK2 DST PAK2 PLEC

6.65e-0459917114GO:0050839
GeneOntologyMolecularFunctioncalcium ion binding

PLCZ1 FBLN5 ANXA3 CDHR3 PPP2R3B ACTN4 ACTN1 ACTN2 ACTN3 PITPNM1 FAT1 DST MCTP1 HMCN1 CADPS SLIT1

7.29e-0474917116GO:0005509
GeneOntologyBiologicalProcesscell-substrate junction assembly

ACTN1 ACTN2 ACTN3 PTK2 CORO2B DST ARHGEF7 PLEC

3.30e-061081718GO:0007044
GeneOntologyBiologicalProcesscell-substrate junction organization

ACTN1 ACTN2 ACTN3 PTK2 CORO2B DST ARHGEF7 PLEC

5.27e-061151718GO:0150115
GeneOntologyBiologicalProcessorganelle assembly

MKKS SLC9A8 PPAN DYNC2H1 DHX37 CEP290 BBS1 SPACA9 ACTN2 RILP TEKT5 PGM5 TBC1D8 TUBGCP6 UBAP2L AVIL ARL13B ASPM MFN2 SCFD1 PLEC DNAAF1 DNAH8 KPNB1

2.39e-05113817124GO:0070925
GeneOntologyBiologicalProcessphotoreceptor cell maintenance

MKKS CEP290 BBS1 CLCN3 ATP1B2

4.27e-05471715GO:0045494
GeneOntologyCellularComponentpseudopodium

ACTN4 ACTN1 ACTN2 ACTN3

1.21e-05181714GO:0031143
GeneOntologyCellularComponentcell-substrate junction

ARHGAP24 ACTN4 ACTN1 ACTN2 ACTN3 PTK2 PGM5 FAT1 CORO2B DST HMCN1 ARHGEF7 AVIL PLEC

1.77e-0544317114GO:0030055
GeneOntologyCellularComponentcontractile actin filament bundle

ACTN4 ACTN1 PTK2 PGM5 AFAP1L1 CORO2B DST

2.84e-051071717GO:0097517
GeneOntologyCellularComponentstress fiber

ACTN4 ACTN1 PTK2 PGM5 AFAP1L1 CORO2B DST

2.84e-051071717GO:0001725
GeneOntologyCellularComponentZ disc

CACNA1C ACTN4 ACTN1 ACTN2 ACTN3 PGM5 DST PLEC

3.50e-051511718GO:0030018
GeneOntologyCellularComponentanchoring junction

ARHGAP24 DSP CDHR3 ACTN4 ACTN1 ACTN2 ACTN3 AQP4 PANX3 PTK2 PGM5 AFAP1L1 FAT1 CORO2B DST HMCN1 ARHGEF7 AVIL PAK2 PLEC WNK4

5.02e-0597617121GO:0070161
GeneOntologyCellularComponentactomyosin

ACTN4 ACTN1 PTK2 PGM5 AFAP1L1 CORO2B DST

5.05e-051171717GO:0042641
GeneOntologyCellularComponentactin filament bundle

ACTN4 ACTN1 PTK2 PGM5 AFAP1L1 CORO2B DST

5.33e-051181717GO:0032432
GeneOntologyCellularComponentfocal adhesion

ARHGAP24 ACTN4 ACTN1 ACTN2 ACTN3 PTK2 PGM5 FAT1 CORO2B DST ARHGEF7 AVIL PLEC

5.74e-0543117113GO:0005925
GeneOntologyCellularComponentI band

CACNA1C ACTN4 ACTN1 ACTN2 ACTN3 PGM5 DST PLEC

6.85e-051661718GO:0031674
GeneOntologyCellularComponentlate endosome membrane

SLC9A8 ADAM30 RILP CLCN3 ABCA5 OSBPL9 OSBPL11 SORL1

1.16e-041791718GO:0031902
GeneOntologyCellularComponentsarcomere

CACNA1C ACTN4 ACTN1 ACTN2 ACTN3 PGM5 DST LRRC27 PLEC

2.18e-042491719GO:0030017
GeneOntologyCellularComponentintercalated disc

DSP ACTN1 PTK2 PGM5 DST

2.37e-04681715GO:0014704
GeneOntologyCellularComponentaxoneme

DYNC2H1 BBS1 SPACA9 TEKT5 DNAH12 ARL13B DNAAF1 DNAH8

3.13e-042071718GO:0005930
GeneOntologyCellularComponentciliary plasm

DYNC2H1 BBS1 SPACA9 TEKT5 DNAH12 ARL13B DNAAF1 DNAH8

3.23e-042081718GO:0097014
GeneOntologyCellularComponentcell-cell junction

ARHGAP24 DSP CDHR3 ACTN4 ACTN1 AQP4 PANX3 PTK2 PGM5 FAT1 DST HMCN1 PAK2 WNK4

3.72e-0459117114GO:0005911
GeneOntologyCellularComponentmyofibril

CACNA1C ACTN4 ACTN1 ACTN2 ACTN3 PGM5 DST LRRC27 PLEC

4.28e-042731719GO:0030016
GeneOntologyCellularComponentsecretory vesicle

SLC9A8 VWF WDR7 DSP ANXA3 CEP290 CEACAM3 TMPRSS4 ACTN4 SPACA9 PSMD12 ACTN1 ACTN2 SNAP47 MCTP1 CLCN3 CADPS PAK2 BRSK1 KLK2 CYB5R1 KPNB1

5.46e-04124617122GO:0099503
GeneOntologyCellularComponentsupramolecular fiber

CACNA1C FBLN5 DSP DYNC2H1 CCT4 ACTN4 SPACA9 ACTN1 ACTN2 ACTN3 TEKT5 PGM5 TUBGCP6 DNAH12 DST AVIL LRRC27 ASPM PLEC POTEI DNAH8

6.57e-04117917121GO:0099512
GeneOntologyCellularComponentcontractile muscle fiber

CACNA1C ACTN4 ACTN1 ACTN2 ACTN3 PGM5 DST LRRC27 PLEC

6.61e-042901719GO:0043292
GeneOntologyCellularComponentsupramolecular polymer

CACNA1C FBLN5 DSP DYNC2H1 CCT4 ACTN4 SPACA9 ACTN1 ACTN2 ACTN3 TEKT5 PGM5 TUBGCP6 DNAH12 DST AVIL LRRC27 ASPM PLEC POTEI DNAH8

7.16e-04118717121GO:0099081
GeneOntologyCellularComponentprotein phosphatase 4 complex

PPP4R1 PPP4R3C

9.77e-0461712GO:0030289
GeneOntologyCellularComponentsarcolemma

CACNA1C AQP4 PTK2 PGM5 DST CLCN1 PLEC

9.82e-041901717GO:0042383
GeneOntologyCellularComponentplatelet alpha granule

VWF ACTN4 ACTN1 ACTN2 CYB5R1

1.00e-03931715GO:0031091
GeneOntologyCellularComponentcell-cell contact zone

DSP ACTN1 PTK2 PGM5 DST

1.05e-03941715GO:0044291
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

DYNC2H1 BBS1 SPACA9 TEKT5 DNAH12 DST ARL13B DNAAF1 DNAH8

1.23e-033171719GO:0032838
GeneOntologyCellularComponentsecretory granule

SLC9A8 VWF DSP ANXA3 CEP290 CEACAM3 TMPRSS4 ACTN4 SPACA9 PSMD12 ACTN1 ACTN2 CLCN3 CADPS PAK2 KLK2 CYB5R1 KPNB1

1.68e-03101417118GO:0030141
GeneOntologyCellularComponentplatelet alpha granule lumen

VWF ACTN4 ACTN1 ACTN2

2.22e-03671714GO:0031093
GeneOntologyCellularComponentNLS-dependent protein nuclear import complex

KPNA7 KPNB1

2.87e-03101712GO:0042564
GeneOntologyCellularComponentdense core granule membrane

ACTN1 CADPS

2.87e-03101712GO:0032127
GeneOntologyCellularComponentcytoplasmic region

DYNC2H1 BBS1 SPACA9 TEKT5 DNAH12 DST ARL13B DNAAF1 DNAH8

2.92e-033601719GO:0099568
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

DSP DYNC2H1 CCT4 SPACA9 ACTN1 ACTN2 ACTN3 TEKT5 TUBGCP6 DNAH12 DST AVIL ASPM PLEC POTEI DNAH8

2.95e-0389917116GO:0099513
GeneOntologyCellularComponenthemidesmosome

DST PLEC

3.49e-03111712GO:0030056
GeneOntologyCellularComponentcell cortex

ACTN4 ACTN1 ACTN2 ACTN3 PTK2 FRY DST HMCN1 ARHGEF7

3.56e-033711719GO:0005938
MousePhenoreduced fertility

EPHB6 TSNAXIP1 PLCZ1 ABCA1 MAGEL2 CEACAM3 SMC6 HELQ AQP4 PANX3 NR2F2 KMT2C RIF1 KPNA7 CLCN1 CLCN3 NFIA UBAP2L NR5A2 ASPM AFF1 TNFAIP3 GABRA1

4.29e-0684413323MP:0001921
MousePhenoenlarged lateral ventricles

MKKS CACNA1C BBS1 CLCN3 NFIX ASPM ATP1B2

1.48e-05841337MP:0008535
DomainSpectrin_repeat

DSP ACTN4 ACTN1 ACTN2 ACTN3 DST PLEC

5.79e-09291697IPR002017
DomainSPEC

DSP ACTN4 ACTN1 ACTN2 ACTN3 DST PLEC

1.22e-08321697SM00150
DomainSpectrin/alpha-actinin

DSP ACTN4 ACTN1 ACTN2 ACTN3 DST PLEC

1.22e-08321697IPR018159
DomainACTININ_2

ACTN4 ACTN1 ACTN2 ACTN3 DST PLEC

4.46e-08231696PS00020
DomainACTININ_1

ACTN4 ACTN1 ACTN2 ACTN3 DST PLEC

4.46e-08231696PS00019
DomainActinin_actin-bd_CS

ACTN4 ACTN1 ACTN2 ACTN3 DST PLEC

4.46e-08231696IPR001589
DomainEFhand_Ca_insen

ACTN4 ACTN1 ACTN2 ACTN3

9.57e-0861694PF08726
DomainEF-hand_Ca_insen

ACTN4 ACTN1 ACTN2 ACTN3

9.57e-0861694IPR014837
DomainCH

ACTN4 ACTN1 ACTN2 ACTN3 DST ARHGEF7 ASPM PLEC

1.24e-07651698SM00033
DomainCH

ACTN4 ACTN1 ACTN2 ACTN3 DST ARHGEF7 ASPM PLEC

2.23e-07701698PF00307
Domain-

ACTN4 ACTN1 ACTN2 ACTN3 DST ARHGEF7 ASPM PLEC

2.49e-077116981.10.418.10
DomainCH

ACTN4 ACTN1 ACTN2 ACTN3 DST ARHGEF7 ASPM PLEC

3.10e-07731698PS50021
DomainCH-domain

ACTN4 ACTN1 ACTN2 ACTN3 DST ARHGEF7 ASPM PLEC

3.84e-07751698IPR001715
DomainSpectrin

ACTN4 ACTN1 ACTN2 ACTN3 DST

1.69e-06231695PF00435
DomainCOUP_TF

NR2F6 NR2F1 NR2F2

7.18e-0651693IPR003068
Domain-

DSP DST PLEC

1.43e-05616933.90.1290.10
DomainPlectin

DSP DST PLEC

2.48e-0571693PF00681
DomainPlectin_repeat

DSP DST PLEC

2.48e-0571693IPR001101
DomainPLEC

DSP DST PLEC

2.48e-0571693SM00250
DomainAAA

ABCA1 LONP2 DYNC2H1 ABCF2 DNAH12 ABCA5 MCM9 DNAH8

5.04e-051441698SM00382
DomainAAA+_ATPase

ABCA1 LONP2 DYNC2H1 ABCF2 DNAH12 ABCA5 MCM9 DNAH8

5.04e-051441698IPR003593
Domain-

PPP4R1 TRRAP RIF1 KPNA7 ASPM MROH7 UTP20 ZER1 KPNB1

1.94e-0422216991.25.10.10
DomainDynein_heavy_chain_D4_dom

DYNC2H1 DNAH12 DNAH8

2.46e-04141693IPR024317
DomainDynein_heavy_dom-2

DYNC2H1 DNAH12 DNAH8

2.46e-04141693IPR013602
DomainDHC_N2

DYNC2H1 DNAH12 DNAH8

2.46e-04141693PF08393
DomainATPase_dyneun-rel_AAA

DYNC2H1 DNAH12 DNAH8

2.46e-04141693IPR011704
DomainAAA_8

DYNC2H1 DNAH12 DNAH8

2.46e-04141693PF12780
DomainAAA_5

DYNC2H1 DNAH12 DNAH8

2.46e-04141693PF07728
DomainARM-type_fold

PPP4R1 TRPC4AP INTS1 TRRAP RIF1 KPNA7 ASPM MROH7 UTP20 ZER1 KPNB1

2.70e-0433916911IPR016024
Domain-

HDHD5 ACAD10 HDHD2 NT5DC3 PITPNM1

2.83e-046416953.40.50.1000
DomainDHC_fam

DYNC2H1 DNAH12 DNAH8

3.06e-04151693IPR026983
DomainDynein_heavy

DYNC2H1 DNAH12 DNAH8

3.06e-04151693PF03028
DomainDynein_heavy_dom

DYNC2H1 DNAH12 DNAH8

3.06e-04151693IPR004273
DomainKinase-like_dom

EPHB3 EPHB6 PRKD2 DDR1 RIPK1 ACAD10 ERN2 TRRAP PTK2 DST SIK2 PAK2 BRSK1 WNK4

4.24e-0454216914IPR011009
DomainCTF_NFI

NFIA NFIX

4.83e-0441692PF00859
DomainCTF_NFI_1

NFIA NFIX

4.83e-0441692PS00349
DomainCTF_NFI_2

NFIA NFIX

4.83e-0441692PS51080
DomainCTF/NFI_DNA-bd-dom

NFIA NFIX

4.83e-0441692IPR020604
DomainNfI_DNAbd_pre-N

NFIA NFIX

4.83e-0441692PF10524
DomainCTF/NFI

NFIA NFIX

4.83e-0441692IPR000647
DomainGHMP_KINASES_ATP

GALK1 MVK

4.83e-0441692PS00627
DomainCTF/NFI_DNA-bd_N

NFIA NFIX

4.83e-0441692IPR019548
DomainMevalonate/galactokinase

GALK1 MVK

4.83e-0441692IPR006206
DomainGHMP_knse_ATP-bd_CS

GALK1 MVK

4.83e-0441692IPR006203
DomainCTF/NFI_DNA-bd_CS

NFIA NFIX

4.83e-0441692IPR019739
DomainCTCK_1

VWF SLIT1 MUC5AC

5.37e-04181693PS01185
DomainP-loop_NTPase

ABCA1 LONP2 DYNC2H1 DHX37 SMC6 ABCF2 HELQ DHX8 NLRP14 MYO15B DNAH12 ABCA5 AK5 MCM9 ARL13B ASPM MFN2 DNAH8

6.91e-0484816918IPR027417
DomainHAD-like_dom

HDHD5 ACAD10 HDHD2 NT5DC3 PITPNM1

7.51e-04791695IPR023214
DomainZnf_hrmn_rcpt

NR2F6 NR2F1 NR2F2 NR5A2

7.85e-04461694IPR001628
DomainNUCLEAR_REC_DBD_2

NR2F6 NR2F1 NR2F2 NR5A2

7.85e-04461694PS51030
DomainNUCLEAR_REC_DBD_1

NR2F6 NR2F1 NR2F2 NR5A2

7.85e-04461694PS00031
DomainZnF_C4

NR2F6 NR2F1 NR2F2 NR5A2

7.85e-04461694SM00399
Domainzf-C4

NR2F6 NR2F1 NR2F2 NR5A2

7.85e-04461694PF00105
DomainNuclear_hrmn_rcpt

NR2F6 NR2F1 NR2F2 NR5A2

7.85e-04461694IPR001723
DomainGHMP_kinases_C

GALK1 MVK

8.00e-0451692PF08544
DomainHAD-SF_hydro_IIA

HDHD5 HDHD2

8.00e-0451692IPR006357
DomainGHMP_kinase_C_dom

GALK1 MVK

8.00e-0451692IPR013750
DomainGHMP_kinase_N_dom

GALK1 MVK

8.00e-0451692IPR006204
DomainHydrolase_6

HDHD5 HDHD2

8.00e-0451692PF13344
DomainGHMP_kinases_N

GALK1 MVK

8.00e-0451692PF00288
Domain-

GALK1 MVK

8.00e-04516923.30.70.890
DomainARM-like

PPP4R1 TRRAP RIF1 KPNA7 ASPM MROH7 UTP20 ZER1 KPNB1

8.07e-042701699IPR011989
Domain-

NR2F6 NR2F1 NR2F2 NR5A2

8.52e-044716941.10.565.10
Domain-

GALK1 LONP2 MVK

8.59e-042116933.30.230.10
DomainNucl_hrmn_rcpt_lig-bd

NR2F6 NR2F1 NR2F2 NR5A2

9.23e-04481694IPR000536
DomainHOLI

NR2F6 NR2F1 NR2F2 NR5A2

9.23e-04481694SM00430
DomainHormone_recep

NR2F6 NR2F1 NR2F2 NR5A2

9.23e-04481694PF00104
DomainRibosomal_S5_D2-typ_fold_subgr

GALK1 LONP2 MVK

9.88e-04221693IPR014721
DomainCT

VWF SLIT1 MUC5AC

9.88e-04221693SM00041
Domain-

ABCA1 LONP2 DYNC2H1 DHX37 SMC6 ABCF2 HELQ DHX8 NLRP14 DNAH12 ABCA5 AK5 MCM9 ARL13B MFN2 DNAH8

1.24e-03746169163.40.50.300
DomainEF-hand-dom_pair

CACNA1C PLCZ1 PPP2R3B ACTN4 ACTN1 ACTN2 ACTN3 TBC1D8 DST

1.24e-032871699IPR011992
DomainCys_knot_C

VWF SLIT1 MUC5AC

1.45e-03251693IPR006207
DomainCTCK_2

VWF SLIT1 MUC5AC

1.45e-03251693PS01225
Domain-

NR2F6 NR2F1 NR2F2 NR5A2

1.76e-035716943.30.50.10
DomainZnf_NHR/GATA

NR2F6 NR2F1 NR2F2 NR5A2

1.88e-03581694IPR013088
DomainVWC

VWF CHRDL2 MUC5AC

2.02e-03281693PF00093
DomainDHC_N1

DYNC2H1 DNAH8

2.20e-0381692PF08385
DomainDynein_heavy_dom-1

DYNC2H1 DNAH8

2.20e-0381692IPR013594
Domain-

PLCZ1 PPP2R3B ACTN4 ACTN1 ACTN2 ACTN3 TBC1D8 DST

2.64e-0326116981.10.238.10
DomainHMGI/Y_DNA-bd_CS

PPAN KMT2C DOT1L

2.72e-03311693IPR000637
DomainCl-channel_core

CLCN1 CLCN3

2.81e-0391692IPR014743
Domain-

CLCN1 CLCN3

2.81e-03916921.10.3080.10
DomainVoltage_CLC

CLCN1 CLCN3

2.81e-0391692PF00654
DomainCl-channel_volt-gated

CLCN1 CLCN3

2.81e-0391692IPR001807
DomainGrowth_fac_rcpt_

EPHB3 EPHB6 FBLN5 FAT1 HMCN1 SLIT1

2.99e-031561696IPR009030
DomainRibosomal_S5_D2-typ_fold

GALK1 LONP2 MVK

3.54e-03341693IPR020568
DomainHEAT_REPEAT

PPP4R1 MROH7 UTP20 KPNB1

3.73e-03701694PS50077
DomainPH

PRKD2 ARHGAP24 TEX2 AFAP1L1 CADPS ARHGEF7 OSBPL9 OSBPL11

3.87e-032781698SM00233
DomainPH_domain

PRKD2 ARHGAP24 TEX2 AFAP1L1 CADPS ARHGEF7 OSBPL9 OSBPL11

4.04e-032801698IPR001849
DomainVWFC_1

VWF CHRDL2 MUC5AC

4.17e-03361693PS01208
DomainEphrin_rec_like

EPHB3 EPHB6

4.24e-03111692PF07699
DomainVWFC_2

VWF CHRDL2 MUC5AC

4.87e-03381693PS50184
DomainVWC

VWF CHRDL2 MUC5AC

4.87e-03381693SM00214
DomainPH

PRKD2 ARHGAP24 AFAP1L1 CADPS ARHGEF7 OSBPL9 OSBPL11

4.90e-032291697PF00169
DomainProt_kinase_dom

EPHB3 EPHB6 PRKD2 DDR1 RIPK1 ERN2 PTK2 SIK2 PAK2 BRSK1 WNK4

5.03e-0348916911IPR000719
DomainMAD_homology1_Dwarfin-type

NFIA NFIX

5.06e-03121692IPR003619
DomainDWA

NFIA NFIX

5.06e-03121692SM00523
DomainOxysterol-bd_CS

OSBPL9 OSBPL11

5.06e-03121692IPR018494
DomainABC_A

ABCA1 ABCA5

5.06e-03121692IPR026082
DomainOxysterol_BP

OSBPL9 OSBPL11

5.06e-03121692PF01237
PathwayREACTOME_EPHRIN_SIGNALING

EPHB3 EPHB6 ARHGEF7 PAK2

1.91e-05181304MM15024
PathwayREACTOME_EPHRIN_SIGNALING

EPHB3 EPHB6 ARHGEF7 PAK2

2.40e-05191304M27310
PathwayREACTOME_NEPHRIN_FAMILY_INTERACTIONS

ACTN4 ACTN1 ACTN2 ACTN3

5.34e-05231304M913
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

CACNA1C DSP ACTN4 ACTN1 ACTN2 ACTN3

6.07e-05741306M16376
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

CACNA1C DSP ACTN4 ACTN1 ACTN2 ACTN3

6.07e-05741306M39462
PathwayREACTOME_APOPTOTIC_EXECUTION_PHASE

DSP PTK2 PAK2 PLEC KPNB1

1.13e-04521305M2341
PathwayBIOCARTA_CELL2CELL_PATHWAY

ACTN1 ACTN2 ACTN3

1.59e-04121303M12851
PathwayBIOCARTA_UCALPAIN_PATHWAY

ACTN1 ACTN2 ACTN3

2.59e-04141303M13143
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CAD DSP POLA1 DHX37 SMCHD1 INTS1 ACTN4 PSMD12 ACTN1 URB2 PRPF8 TRRAP NDUFS1 DHX8 RIF1 DST UBAP2L UTP20 PLEC KPNB1 PTCD3

1.40e-116531722122586326
Pubmed

Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network.

ACTN4 ACTN1 ACTN2 ACTN3

5.78e-10417241629252
Pubmed

Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.

ACTN4 ACTN1 ACTN2 ACTN3

5.78e-104172416807302
Pubmed

Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.

ACTN4 ACTN1 ACTN2 ACTN3

2.88e-095172415841212
Pubmed

The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.

ACTN4 ACTN1 ACTN2 ACTN3

2.88e-095172412837758
Pubmed

Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.

ACTN4 ACTN1 ACTN2 ACTN3

2.88e-095172419943616
Pubmed

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.

ACTN4 ACTN1 ACTN2 ACTN3

8.60e-096172418425115
Pubmed

The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.

ACTN4 ACTN1 ACTN2 ACTN3

8.60e-096172422693585
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ABI1 CAD VWF WDR7 DSP CCT4 ACTN4 ACTN1 ACTN2 ACTN3 HDHD2 NT5DC3 SNAP47 AQP4 NDUFS1 PITPNM1 SLC44A1 CORO2B DST UBAP2L CADPS OSBPL9 PLEC BRSK1 KPNB1 PTCD3

1.05e-0814311722637142655
Pubmed

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function.

ACTN4 ACTN1 ACTN2 ACTN3

3.98e-088172420215401
Pubmed

Mice deficient in alpha-actinin-4 have severe glomerular disease.

ACTN4 ACTN1 ACTN2 ACTN3

3.98e-088172412782671
Pubmed

Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.

ACTN4 ACTN1 ACTN2 ACTN3

1.19e-0710172420368620
Pubmed

BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.

ACTN2 DST PLEC

1.19e-073172319932097
Pubmed

The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.

ACTN4 ACTN2 ACTN3

1.19e-073172310656685
Pubmed

α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.

ACTN4 ACTN1 ACTN3

1.19e-073172321784188
Pubmed

The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.

NR2F6 NR2F1 NR2F2

1.19e-073172318701084
Pubmed

Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.

ACTN4 ACTN2 ACTN3

1.19e-07317238104223
Pubmed

A human MAP kinase interactome.

VWF RIPK1 DSP CEP290 ACTN4 ACTN1 PTK2 KMT2C RIF1 DST ARHGEF7 PAK2 TNFAIP3 PLEC

1.59e-074861721420936779
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

PRKD2 CAD DSP DYNC2H1 POLA1 DHX37 SMCHD1 SMC6 ABCF2 CCT4 ACTN4 PSMD12 URB2 PRPF8 NDUFS1 DHX8 RIF1 UBAP2L RBM5 UTP20 SCFD1 TDRD6 KPNB1 PTCD3

1.66e-0714251722430948266
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

CAD PPAN DSP SMCHD1 CEP290 INTS1 ABCF2 CCT4 ACTN4 ACTN1 URB2 PRPF8 TRRAP DHX8 RIF1 DST UBAP2L UTP20 PLEC KPNB1

1.96e-0710241722024711643
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

CAD GALK1 DSP POLA1 DHX37 SMCHD1 ABCF2 CCT4 ACTN4 ACTN1 URB2 PRPF8 TRRAP NDUFS1 PTK2 RIF1 DST ASPM UTP20 SCFD1 PLEC KPNB1 PTCD3

2.62e-0713531722329467282
Pubmed

Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.

ACTN4 ACTN1 ACTN2 ACTN3

2.77e-0712172415465019
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

DSP DYNC2H1 INTS1 ACTN1 SNAP47 KMT2C DST UBAP2L SLIT1 PAXIP1 KPNB1

6.78e-073221721126514267
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TRPC4AP ABI1 LONP2 DYNC2H1 CEP290 SMC6 BBS1 ACTN4 GOLPH3 PSMD12 ACTN1 PRPF8 SNAP47 NDUFS1 RIF1 NAF1 NADK PLEC DNAAF1 MUC5AC SORL1 KPNB1

6.88e-0713211722227173435
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

PPP4R1 CAD CENPN POLA1 SMC6 INTS1 YRDC SPACA9 TRRAP NDUFS1 KMT2C SLC44A1 CORO2B ARHGEF7 MCM9 NR5A2 PAXIP1 ASPM RBM5 PAK2 MFN2 MTBP

7.41e-0713271722232694731
Pubmed

Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.

ACTN4 ACTN1 ACTN2 ACTN3

7.56e-0715172411440986
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CACNA1C PPAN DSP CES1 TRO SMCHD1 ABCF2 CCT4 ACTN4 ACTN1 ACTN2 ACTN3 PRPF8 NDUFS1 DST CLCN3 AVIL ASPM RBM5 PLEC POTEI DNAH8 KPNB1

7.88e-0714421722335575683
Pubmed

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

ANXA3 ABCF2 CCT4 ACTN4 ACTN1 UBAP2L NFIX PLEC

9.73e-07152172816009940
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

CAD DSP DHX37 SMCHD1 INTS1 ACTN1 PRPF8 NR2F1 NR2F2 RIF1 NFIA NFIX PAXIP1 KPNB1

1.39e-065831721429844126
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

CACNA1C ABI1 WDR7 TEX2 PTK2 PITPNM1 DST UBAP2L ARHGEF7 PLEC GABRA1

1.41e-063471721117114649
Pubmed

Exome sequencing supports a de novo mutational paradigm for schizophrenia.

TEKT5 TRRAP ADCY7 PITPNM1 ADGRF4

1.60e-0640172521822266
Pubmed

Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.

NR2F6 NR2F1 NR2F2

2.35e-06617237947324
Pubmed

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.

ACTN4 ACTN1 ACTN3 MYO15B PLEC

2.91e-0645172522114352
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

CAD GALK1 DSP SMCHD1 ACTN1 TRRAP KMT2C UBAP2L OSBPL9 OSBPL11 PAK2 DOT1L KPNB1

3.89e-065491721338280479
Pubmed

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

NR2F6 NR2F1 NR2F2 NR5A2

3.94e-0622172423975195
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

ABI1 CAD DSP TEX2 CCT4 ACTN4 PSMD12 LRRC4C NT5DC3 SNAP47 AQP4 NDUFS1 PITPNM1 UBAP2L CADPS ARHGEF7 PLEC GABRA1 PTCD3

4.09e-0611391721936417873
Pubmed

Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.

ACTN4 ACTN1 ACTN2

4.10e-067172311724819
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

CAD GALK1 DSP ANXA3 CCT4 ACTN4 PSMD12 ACTN1 ACTN2 ACTN3 NDUFS1 PLEC KPNB1 PTCD3

4.62e-066471721426618866
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

CAD PPAN DHX37 ABCF2 CCT4 URB2 PRPF8 DHX8 RIF1 UBAP2L UTP20 KPNB1

5.72e-064831721236912080
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PPAN DHX37 SMCHD1 SMC6 ABCF2 URB2 PRPF8 TRRAP NR2F2 DHX8 RIF1 UBAP2L MCM9 ASPM UTP20

6.21e-067591721535915203
Pubmed

Expansion of the lateral ventricles and ependymal deficits underlie the hydrocephalus evident in mice lacking the transcription factor NFIX.

BMP6 NFIA NFIX

6.54e-068172325960350
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

ACTN4 SPACA9 URB2 RILP PRPF8 NR2F2 FAT1 DST PLEC KPNB1

6.71e-063321721037433992
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

DSP SMCHD1 CEP290 HMGXB4 INTS1 ABCF2 PRPF8 TRRAP NR2F1 DHX8 KMT2C RIF1 DST NFIA NFIX PAXIP1 RBM5 UTP20 NAIF1 KPNB1

6.97e-0612941722030804502
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

CAD DSP LONP2 POLA1 HDHD5 SMCHD1 YRDC ABCF2 CCT4 ACTN4 ACTN1 PRPF8 PTER DHX8 RIF1 UBAP2L ARHGEF7 NAF1 PLEC KPNB1 PTCD3

7.50e-0614151722128515276
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

ABI1 VWF DSP ABCF2 ACTN4 ACTN2 ACTN3 NDUFS1 DST RBM5 PLEC KPNB1

7.63e-064971721223414517
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NR2F6 PPAN DSP TRRAP PITPNM1 TUBGCP6 RIF1 NFIA UBAP2L NAF1 OSBPL11 AFF1 UTP20 SCFD1 PLEC

7.84e-067741721515302935
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

CAD DSP SMCHD1 PRPF8 UBAP2L MROH7 UTP20 PLEC

8.05e-06202172833005030
Pubmed

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.

ACTN4 ACTN1 ACTN2 ACTN3

9.28e-0627172436899856
Pubmed

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

ACTN1 ACTN2 ACTN3

9.77e-069172311114196
Pubmed

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

DSP DST PLEC

9.77e-069172312482924
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

PRKD2 PPAN GALK1 LONP2 DYNC2H1 POLA1 BBS1 PSMD12 PRPF8 TRRAP NDUFS1 DHX8 NAF1 OSBPL9 OSBPL11 TNFAIP3 PLEC

1.13e-0510051721719615732
Pubmed

Genomic analysis of mouse retinal development.

DDR1 NR2F6 ABI1 SMC6 ABCF2 PTK2 BMP6 DST CADPS MCM9 SLIT1 UTP20 PPIP5K1 TNFAIP3 PLEC ATP1B2 KPNB1

1.15e-0510061721715226823
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

PRKD2 CAD POLA1 DHX37 HDHD5 CCT4 PSMD12 URB2 PRPF8 TRRAP DHX8 UTP20 SCFD1 DNAH8

1.19e-057041721429955894
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

CAD DSP POLA1 ACTN4 DST UBAP2L ADAMTS15 TDRD6 PLEC

1.31e-05284172929459677
Pubmed

DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.

DSP ACTN4 ACTN1 PLEC KPNB1

1.56e-0563172537052853
Pubmed

E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1.

DSP CCT4 ACTN4 ACTN1

1.64e-0531172433777788
Pubmed

HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.

POLA1 ACTN4 ACTN1 UBAP2L

1.86e-0532172427114546
Pubmed

A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.

PGM5 NFIA NFIX

1.90e-0511172322925353
Pubmed

Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.

ACTN2 ACTN3 KLK2

1.90e-0511172316585392
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

DSP DST PLEC

1.90e-0511172312802069
Pubmed

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

RIPK1 DYNC2H1 TRO GOLPH3 SNAP47 TNFAIP3 PLEC DNAAF1 DNAH8

2.13e-05302172930561431
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

EPHB6 PPP4R1 PRKD2 VWF DSP CEP290 ACTN4 ACTN1 PRPF8 PTK2 FRY RNF123 CORO2B DST CADPS ARL13B PAK2 PLEC KPNB1

2.21e-0512851721935914814
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

EPHB3 DDR1 DYNC2H1 TRO HDHD5 SMCHD1 NLRX1 SMC6 INTS1 ACAD10 PSMD12 TBC1D8 RIF1 FAT1 NR5A2 RBM5 SCFD1

2.26e-0510611721733845483
Pubmed

CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.

SPTLC3 DSP CEP290 ACTN4 PSMD12 ACTN1 CORO2B ABCA5 MFN2 PLEC KPNB1

2.36e-054681721136042349
Pubmed

COUP-TFI and -TFII nuclear receptors are expressed in amacrine cells and play roles in regulating the differentiation of retinal progenitor cells.

NR2F1 NR2F2

2.43e-052172219766631
Pubmed

Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.

RIPK1 PTK2

2.43e-052172215121855
Pubmed

OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface.

OSBPL9 OSBPL11

2.43e-052172220599956
Pubmed

A new interaction between Abi-1 and betaPIX involved in PDGF-activated actin cytoskeleton reorganisation.

ABI1 ARHGEF7

2.43e-052172216940963
Pubmed

EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.

EPHB3 EPHB6

2.43e-052172222039307
Pubmed

Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome.

NR2F1 NR2F2

2.43e-052172228963436
Pubmed

An analysis of splicing, actin-binding properties, heterodimerization and molecular interactions of the non-muscle α-actinins.

ACTN4 ACTN1

2.43e-052172223557398
Pubmed

Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.

ACTN2 ACTN3

2.43e-052172219150855
Pubmed

ACTN4 regulates the stability of RIPK1 in melanoma.

RIPK1 ACTN4

2.43e-052172229706658
Pubmed

Localization of transcripts of the related nuclear orphan receptors COUP-TF I and ARP-1 in the adult mouse brain.

NR2F1 NR2F2

2.43e-05217227609634
Pubmed

Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.

NR2F6 NR2F1

2.43e-05217222905047
Pubmed

Subcellular knockout of importin β1 perturbs axonal retrograde signaling.

AVIL KPNB1

2.43e-052172222841314
Pubmed

α-Actinin-2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α-actinin-3 revealing functional differences between sarcomeric isoforms.

ACTN2 ACTN3

2.43e-052172222253474
Pubmed

alpha-actinin-3 and performance.

ACTN2 ACTN3

2.43e-052172219696509
Pubmed

Apparent but unconfirmed digenism in an Iranian consanguineous family with syndromic Retinal Disease.

MKKS CEP290

2.43e-052172233741323
Pubmed

Protein kinase D2 promotes the proliferation of glioma cells by regulating Golgi phosphoprotein 3.

PRKD2 GOLPH3

2.43e-052172225218347
Pubmed

Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells.

ACTN4 ACTN1

2.43e-052172220156433
Pubmed

FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.

PTK2 ARHGEF7

2.43e-052172217093062
Pubmed

Competition between α-actinin and Ca²⁺-calmodulin controls surface retention of the L-type Ca²⁺ channel Ca(V)1.2.

ACTN1 ACTN2

2.43e-052172223664615
Pubmed

Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes.

ACTN2 ACTN3

2.43e-052172232451822
Pubmed

Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis.

MKKS CEP290

2.43e-052172222446187
Pubmed

Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11.

ACTN2 ACTN3

2.43e-05217221339456
Pubmed

Upregulated of ANXA3, SORL1, and Neutrophils May Be Key Factors in the Progressionof Ankylosing Spondylitis.

ANXA3 SORL1

2.43e-052172235464477
Pubmed

The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase.

ACTN1 PTK2

2.43e-052172211369769
Pubmed

Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells.

ABCF2 ACTN4

2.43e-052172222252987
Pubmed

Distinct forms of the actin cross-linking protein α-actinin support macropinosome internalization and trafficking.

ACTN4 ACTN1

2.43e-052172234010028
Pubmed

Human skeletal muscle-specific alpha-actinin-2 and -3 isoforms form homodimers and heterodimers in vitro and in vivo.

ACTN2 ACTN3

2.43e-05217229675099
Pubmed

Characterization of the Importin-β binding domain in nuclear import receptor KPNA7.

KPNA7 KPNB1

2.43e-052172231642884
Pubmed

An evolutionary conserved COUP-TF binding element in a neural-specific gene and COUP-TF expression patterns support a major role for COUP-TF in neural development.

NR2F1 NR2F2

2.43e-05217227708064
Pubmed

Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis.

NR2F1 NR2F2

2.43e-05217227626501
Pubmed

Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology.

ACTN4 ACTN1

2.43e-052172220037648
Pubmed

Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon.

NR2F1 NR2F2

2.43e-05217228183930
Pubmed

HAMLET binding to α-actinin facilitates tumor cell detachment.

ACTN4 ACTN1

2.43e-052172221408150
Pubmed

Actinin-1 and actinin-4 play essential but distinct roles in invadopodia formation by carcinoma cells.

ACTN4 ACTN1

2.43e-052172228797528
Pubmed

Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear.

NR2F1 NR2F2

2.43e-052172215907456
Pubmed

Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1.

DDR1 TMPRSS4

2.43e-052172231659178
InteractionSIRT7 interactions

CAD DSP POLA1 DHX37 SMCHD1 INTS1 ACTN4 PSMD12 ACTN1 URB2 PRPF8 TRRAP NDUFS1 DHX8 RIF1 DST UBAP2L UTP20 PLEC KPNB1 PTCD3

1.30e-0674417021int:SIRT7
InteractionOBSL1 interactions

EPHB6 FBLN5 CAD PPAN DSP SMCHD1 ACTN4 PSMD12 ACTN1 URB2 PRPF8 TRRAP DHX8 RIF1 DST UBAP2L NR5A2 SIK2 UTP20 PLEC DNAAF1 KPNB1

7.58e-0690217022int:OBSL1
InteractionCOL17A1 interactions

DSP ACTN4 ACTN1 DST PLEC

9.19e-06341705int:COL17A1
InteractionPPP1CB interactions

CAD INTS1 CCT4 ACTN4 ACTN1 ACTN2 PTK2 RIF1 DST SIK2 PAK2 PLEC DOT1L MVK KPNB1

1.09e-0546917015int:PPP1CB
InteractionITGB4 interactions

DDR1 RIPK1 ADAM30 NT5DC3 PTK2 DST PLEC MUC5AC

1.11e-051251708int:ITGB4
InteractionNBR1 interactions

CAD RIPK1 DSP SMCHD1 CCT4 ACAD10 PSMD12 TRRAP NDUFS1 DST MFN2 B3GAT1 KPNB1

2.14e-0538017013int:NBR1
InteractionMYOZ2 interactions

ACTN4 ACTN1 ACTN2 ACTN3

3.18e-05221704int:MYOZ2
InteractionDUSP16 interactions

CAD RIPK1 DYNC2H1 TRO PRPF8 TUBGCP6 RNF123 SIK2 OSBPL11 PPIP5K1

3.44e-0523717010int:DUSP16
GeneFamilyActinins

ACTN4 ACTN1 ACTN2 ACTN3

1.55e-09411541112
GeneFamilyEF-hand domain containing|Plakins

DSP DST PLEC

1.37e-0581153939
GeneFamilyNuclear hormone receptors

NR2F6 NR2F1 NR2F2 NR5A2

2.64e-0449115471
GeneFamilyBardet-Biedl syndrome associated|BBSome

MKKS CEP290 BBS1

3.07e-04211153980
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PRKD2 ARHGAP24 AFAP1L1 CADPS ARHGEF7 OSBPL9 OSBPL11

3.49e-042061157682
GeneFamilyFibulins

FBLN5 HMCN1

1.10e-0381152556
GeneFamilyChloride voltage-gated channels

CLCN1 CLCN3

1.75e-03101152302
GeneFamilyOxysterol binding proteins|Pleckstrin homology domain containing

OSBPL9 OSBPL11

2.54e-03121152670
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB3 EPHB6

3.47e-031411521095
GeneFamilyATP binding cassette subfamily A

ABCA1 ABCA5

3.47e-03141152805
GeneFamilyChaperonins

MKKS CCT4

3.99e-03151152587
GeneFamilyDEAH-box helicases

DHX37 DHX8

4.54e-03161152500
GeneFamilyDyneins, axonemal

DNAH12 DNAH8

5.12e-03171152536
GeneFamilyCadherin related

CDHR3 FAT1

5.12e-0317115224
GeneFamilyArmadillo repeat containing|Importins

KPNA7 KPNB1

5.74e-03181152596
CoexpressionGSE13493_DP_VS_CD4INTCD8POS_THYMOCYTE_DN

RIPK1 HMGXB4 SMC6 NDUFS1 CADPS PAK2 KYAT3 B3GAT1 TRPM1

7.07e-061991729M3313
CoexpressionGSE2405_HEAT_KILLED_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_9H_DN

CES1 NXPE4 DHX37 TMPRSS4 PTER CORO2B NAF1 SIK2 AFF1

7.37e-062001729M6196
CoexpressionFAN_EMBRYONIC_CTX_ASTROCYTE_2

ABCA1 AQP4 NR2F1 NR2F2 KMT2C DST NFIA ATP1B2

8.45e-061541728M39034
CoexpressionGSE7509_UNSTIM_VS_TNFA_IL1B_IL6_PGE_STIM_DC_UP

ABCA1 TRPC4AP CAD URB2 HDHD2 DHX8 OSBPL11 KPNB1

3.57e-051881728M6819
CoexpressionBUSSLINGER_GASTRIC_G_CELLS

DSP CES1 DST ABCA5 CADPS SORL1

4.68e-05981726M40018
CoexpressionGSE13411_IGM_VS_SWITCHED_MEMORY_BCELL_DN

MKKS CEP290 GOLPH3 GSAP NDUFS1 SIK2 SCFD1 TNFAIP3

5.15e-051981728M3248
CoexpressionGSE3982_MAST_CELL_VS_TH2_UP

WDR7 GSAP PTK2 FAT1 CLCN3 AFF1 GABRA1 CYB5R1

5.15e-051981728M5455
CoexpressionGSE3982_MAST_CELL_VS_NKCELL_UP

ABCA1 PSMD12 PTK2 TBC1D8 FRY FAT1 MCTP1 UTP20

5.34e-051991728M5450
CoexpressionGSE40277_GATA1_AND_SATB1_TRANSDUCED_VS_CTRL_CD4_TCELL_DN

DDR1 ARHGAP24 DYNC2H1 GSAP ACTN1 NT5DC3 TRRAP DNAH8

5.34e-051991728M9178
CoexpressionGSE5589_LPS_VS_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_UP

VWF WDR7 ANXA3 SPACA9 ACAD10 UBAP2L ARHGEF7 LRRC27

5.53e-052001728M6615
CoexpressionHALLMARK_APICAL_JUNCTION

VWF TRO ACTN4 ACTN1 ACTN2 ACTN3 PTK2 WNK4

5.53e-052001728M5915
CoexpressionGSE40068_CXCR5POS_BCL6POS_TFH_VS_CXCR5NEG_BCL6NEG_CD4_TCELL_DN

SMC6 ACTN1 PTK2 NFIX OSBPL9 AFF1 TRPM1 XKRX

5.53e-052001728M9262
CoexpressionINAMURA_LUNG_CANCER_SCC_DN

VWF NR2F2 PGM5

7.57e-05131723M1255
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000

SPTLC3 PRKD2 ABCA1 DSP DHX37 PGM5 CORO2B DST CLCN3 HMCN1 ABCA5 NFIA CADPS NFIX AK5 ADAMTS15 GABRA1 SORL1 KPNB1

2.61e-0580617019gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_top-relative-expression-ranked_500

FBLN5 MAGEL2 VWF TRO ANXA3 PGM5 FRY CORO2B ABCA5 AK5 ADAMTS15 MTBP KPNB1

3.54e-0542017013gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_500
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C ABCA1 CEP290 TMPRSS4 DST ABCA5 CADPS PAXIP1 AFF1

3.27e-081781729fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 ANXA3 TMPRSS4 ACTN4 ACTN1 DST HMCN1 ABCA5 DOT1L

5.00e-081871729f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellBronchial_Brush-Epithelial|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

DDR1 DSP DYNC2H1 CDHR3 DNAH12 ABCA5 NFIA DNAAF1 MUC5AC

7.82e-081971729272c7f4e582ef57564450540242b0db766b78328
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

VWF ACTN1 LRRC4C NR2F2 PGM5 FRY DST HMCN1 PLEC

8.89e-0820017297eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellNS-moderate-d_0-4-Epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PPP4R1 DDR1 DSP CES1 TMPRSS4 ACTN4 ERN2 PTK2 NFIA

8.89e-08200172964462a18afca3c1a8548a857924b8166058bf958
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ABCA1 FBLN5 ACTN1 AQP4 MTCP1 CADPS NFIX DNAH8

1.74e-071561728bb505f639dbcad2b788db62d6084c2cb4e884bec
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN5 VWF POLA1 PGM5 NR5A2 MTBP PRDM15 GABRA1

4.00e-0717417286c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN5 VWF ANXA3 NR2F2 PGM5 DST HMCN1 NFIA

4.75e-0717817285cc182e6faa7ba5b88378d2c953be29bbbb95a7e
ToppCellfacs-Lung-Endomucin-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN5 VWF ANXA3 NR2F2 PGM5 DST HMCN1 NFIA

4.75e-071781728f9a16bc3f09c35c7d30e3809da024bc2dcf746ed
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

PRKD2 DSP SMCHD1 APOL1 KMT2C RIF1 DST TNFAIP3

5.86e-0718317288f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

VWF ACTN1 PGM5 AFAP1L1 BMP6 HMCN1 NFIA AK5

7.48e-0718917287346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FBLN5 CES1 DYNC2H1 NR2F1 PGM5 DST HMCN1 SLIT1

7.48e-071891728203c80030df08ae112f9ae4043709f455d87ce89
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 ANXA3 TMPRSS4 ACTN4 ACTN1 DST HMCN1 ABCA5

7.48e-071891728e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF NR2F2 PGM5 TBC1D8 BMP6 FRY HMCN1 WNK4

8.43e-07192172814a816ef116aa992f86edab411f043cf7d07fe04
ToppCellLPS-antiTNF-Endothelial-Endothelial-Vein|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF ACTN1 LRRC4C NR2F2 PGM5 MCTP1 HMCN1 NR5A2

8.43e-07192172881baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCellfacs-Heart-LA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF NR2F2 PGM5 TBC1D8 BMP6 FRY HMCN1 WNK4

8.43e-071921728847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C FBLN5 ACTN2 NR2F1 NR2F2 DST HMCN1 ADAMTS15

8.76e-071931728b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF PTK2 AFAP1L1 BMP6 DST MCTP1 HMCN1 NR5A2

9.11e-0719417280b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TSNAXIP1 DYNC2H1 CDHR3 CEP290 DNAH12 DNAAF1 CCDC180 WNK4

1.02e-06197172874a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDR1 NR2F6 CDHR3 TMPRSS4 ERN2 DNAH12 DNAAF1 MUC5AC

1.06e-061981728d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCellCerebellum-Macroglia-CSF_related|Cerebellum / BrainAtlas - Mouse McCarroll V32

DSP CDHR3 SPACA9 ARR3 DNAH12 DNAAF1 CCDC180

1.07e-061371727f004199b654143e9e766e5c5f56858089e98cf5f
ToppCellCerebellum-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

DSP CDHR3 SPACA9 ARR3 DNAH12 DNAAF1 CCDC180

1.07e-0613717276a5599af9d0ee1be6cac17af09aa4cd50774c683
ToppCellCerebellum-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

DSP CDHR3 SPACA9 ARR3 DNAH12 DNAAF1 CCDC180

1.07e-06137172701cbc9082e10ef51a1763a8b2d708eea0434490f
ToppCellCerebellum-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)|Cerebellum / BrainAtlas - Mouse McCarroll V32

DSP CDHR3 SPACA9 ARR3 DNAH12 DNAAF1 CCDC180

1.07e-061371727a22730b6f78b66bb3c46155af37c34e554672dee
ToppCellCerebellum-Macroglia-CSF_related-CHOROID_PLEXUS|Cerebellum / BrainAtlas - Mouse McCarroll V32

DSP CDHR3 SPACA9 ARR3 DNAH12 DNAAF1 CCDC180

1.07e-061371727ce7c57dad201bd2164fc8b1172aca709f3f7def2
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA1 FBLN5 DYNC2H1 ACTN2 NR2F1 NR2F2 DST ADAMTS15

1.10e-061991728a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellCOVID-19-kidney-Fibroblast-1|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1C ABCA1 FBLN5 COL15A1 ACTN1 NR2F1 NR2F2 DST

1.10e-0619917289503646ff1ad248181146ce767e9d12e882ec3bd
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

CACNA1C VWF ANXA3 NLRX1 ACTN1 ACTN2 BMP6 FRY

1.14e-062001728032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CACNA1C FBLN5 ACTN2 NR2F1 NR2F2 DST HMCN1 ATP1B2

1.14e-062001728aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

CACNA1C VWF ANXA3 NLRX1 ACTN1 ACTN2 BMP6 FRY

1.14e-06200172868fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

CACNA1C VWF ANXA3 NLRX1 ACTN1 ACTN2 BMP6 FRY

1.14e-062001728376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CACNA1C FBLN5 ACTN2 NR2F1 NR2F2 DST HMCN1 ATP1B2

1.14e-062001728a510deaada669e690329183e18df02870bd204b3
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

CACNA1C VWF ANXA3 NLRX1 ACTN1 ACTN2 BMP6 FRY

1.14e-0620017287fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

ACTN2 LRRC4C PTER AQP4 EXD3 SLIT1 PLEC ATP1B2

1.14e-0620017285c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

CACNA1C VWF ANXA3 NLRX1 ACTN1 ACTN2 BMP6 FRY

1.14e-062001728878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

ABCA1 FBLN5 ACTN2 NR2F1 NR2F2 DST ADAMTS15 ATP1B2

1.14e-062001728bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

CACNA1C VWF ANXA3 NLRX1 ACTN1 ACTN2 BMP6 FRY

1.14e-0620017287136936d05ab344a560cf159684c881063b5430d
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CACNA1C FBLN5 ACTN2 NR2F1 NR2F2 DST HMCN1 ATP1B2

1.14e-062001728dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VWF ANXA3 AFAP1L1 BMP6 CLCN1 MCTP1 NR5A2

3.84e-061661727f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKD2 FBLN5 VWF ANXA3 PGM5 DST GABRA1

4.67e-0617117273112d15f2a28cf4a71992db4971d960716dc1264
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel|Adult / Lineage, Cell type, age group and donor

VWF COL15A1 PGM5 AFAP1L1 MYO15B CADPS NR5A2

4.85e-061721727ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP4R1 NR2F6 RILP ADCY7 PITPNM1 TUBGCP6 NAIF1

5.44e-061751727c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TSNAXIP1 DYNC2H1 CDHR3 SPACA9 DNAH12 DNAAF1 CCDC180

6.54e-06180172792fb01b91261b3103454924cde56add337b41844
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C FBLN5 VWF COL15A1 CHRDL2 CORO2B NFIA

7.03e-061821727fbd5e332df73bf7141c822fa67b76367dc962017
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPHB6 ACTN2 PTER MCTP1 NFIA AK5 ASPM

7.55e-061841727ca35a3d2b536c8b2bf5c4d635605e5a3ae94a428
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_EGR3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPHB6 ACTN2 PTER MCTP1 NFIA AK5 ASPM

8.10e-06186172777b09af860183606a1775eba921e2071e4a7dd4e
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DSP ANXA3 GSAP AQP4 FRY GABRA1 SORL1

8.99e-0618917277659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCelldroplet-Large_Intestine-COLON:P+D-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 ANXA3 ACTN1 AQP4 HMCN1 NFIA ADAMTS15

8.99e-0618917276f1696871a2994fd5f50b7cf4aa00e6d8054b603
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSNAXIP1 VWF NR2F2 PGM5 TBC1D8 HMCN1 WNK4

8.99e-0618917271137583e21d874c201c20581ba1995e2bfa3de59
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBLN5 VWF NR2F2 PGM5 DST PLEC GABRA1

9.31e-061901727e1b721bb74561fe51c53328a0394c9954e489049
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSNAXIP1 VWF NR2F2 PGM5 TBC1D8 HMCN1 WNK4

9.31e-0619017277068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCellfacs-Heart-RV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTLC3 VWF NR2F2 PGM5 AFAP1L1 HMCN1 WNK4

9.63e-061911727f0c649bb32732c9dd38a0af8ce94d2a4d16de39a
ToppCelldroplet-Skin-nan-21m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 SPTLC3 DSP TMPRSS4 TPRG1 ADGRF4 MVK

9.63e-061911727c5ef34d138cd797029dfefaf4c52d16ba6a76c38
ToppCell10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

VWF NR2F1 NR2F2 AFAP1L1 BMP6 HMCN1 NR5A2

9.63e-061911727dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTLC3 VWF NR2F2 PGM5 AFAP1L1 HMCN1 WNK4

9.63e-061911727e518c598719119e60c76016c586b1520c258bbcb
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

VWF ACTN1 NR2F1 AFAP1L1 BMP6 HMCN1 AK5

9.96e-061921727c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1C SPTLC3 NR2F1 NR2F2 PGM5 FAT1 CADPS

9.96e-06192172772881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CACNA1C FBLN5 NR2F1 DST HMCN1 NFIA SLIT1

1.03e-0519317279f69edc97b868d23998abc98928a2e89a885ef8a
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF PTK2 AFAP1L1 BMP6 MCTP1 HMCN1 NR5A2

1.03e-0519317276e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CES1 DYNC2H1 CDHR3 TBC1D8 NFIA NFIX DNAAF1

1.03e-051931727ea345d34440b25f65358a53dc72831998d1c3620
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C FBLN5 ACTN2 NR2F1 DST HMCN1 ADAMTS15

1.03e-05193172799525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF ACTN1 LRRC4C PGM5 AFAP1L1 MCTP1 HMCN1

1.03e-0519317277261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ABCA1 AQP4 NR2F1 NR2F2 DST NFIX ATP1B2

1.07e-05194172708fad7591c20568de797cf8e206de2d0b1d78aab
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TSNAXIP1 DYNC2H1 CDHR3 SPACA9 DNAH12 DNAAF1 CCDC180

1.07e-0519417274a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF CHRDL2 ACTN1 NR2F1 NR2F2 PGM5 AFAP1L1

1.10e-051951727590c0dc0db4dc62879645ed7f61292ff97d2c7d5
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TSNAXIP1 CES1 DYNC2H1 CDHR3 DNAH12 DNAAF1 CCDC180

1.10e-051951727e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA1 DYNC2H1 KMT2C RIF1 DST ABCA5 CADPS

1.10e-0519517277796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellCOVID-19-Epithelial-Ciliated_cells|Epithelial / Condition, Lineage and Cell class

CES1 DYNC2H1 CDHR3 SPACA9 DNAH12 DNAAF1 CCDC180

1.14e-051961727de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ACTN1 NR2F2 PGM5 CLCN3 HMCN1 WNK4

1.14e-0519617277d5eaed189aa6116f3799be010139fb675ec65e0
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AQP4 NR2F1 CLCN3 NFIA CADPS ATP1B2 KPNB1

1.14e-05196172745d1c0a962c4221c17393ee5566961d1deebf442
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CES1 DYNC2H1 CDHR3 TBC1D8 DNAH12 DNAAF1 CCDC180

1.18e-05197172791637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CES1 DYNC2H1 CDHR3 TBC1D8 DNAH12 DNAAF1 CCDC180

1.18e-05197172722c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CES1 DYNC2H1 CDHR3 TBC1D8 DNAH12 DNAAF1 CCDC180

1.18e-0519717273bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CES1 DYNC2H1 CDHR3 TBC1D8 DNAH12 DNAAF1 CCDC180

1.18e-05197172787db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell356C-Fibroblasts-Fibroblast-K_(Pericytes)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL15A1 ACTN1 ACTN2 NR2F2 PTK2 PGM5 FRY

1.18e-05197172771367bebc23d0e81f60f780d6b0ab3a1783ac014
ToppCell356C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL15A1 ACTN1 ACTN2 NR2F2 PTK2 PGM5 FRY

1.18e-0519717270f9836554ace3f9d155ebafdd719aa26466ca44e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF COL15A1 ACTN4 AFAP1L1 FRY HMCN1 NR5A2

1.22e-051981727218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCellwk_08-11-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DSP ANXA3 AQP4 ADCY7 FRY OSBPL9 GABRA1

1.22e-0519817271eb49b853a9e144e840c660060473fc7873f6478
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF DSP AFAP1L1 BMP6 FRY HMCN1 NR5A2

1.26e-051991727c5c12c8288fe868322bae9d691b91fee953ceb3e
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FBLN5 DYNC2H1 ACTN2 NR2F1 NR2F2 DST ADAMTS15

1.26e-05199172730d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Vein|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

VWF ACTN1 LRRC4C NR2F2 PGM5 HMCN1 PLEC

1.26e-051991727cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCellControl-Control-Myeloid-Neutrophil|Control / Disease, condition lineage and cell class

PPP4R1 ANXA3 SMCHD1 CEACAM3 ACTN1 NADK SORL1

1.30e-05200172795c41f147a1594d49e73cb56d86d301c3115ce20
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ACTN1 NR2F2 FAT1 ARHGEF7 AK5 MROH7 ATP1B2

1.30e-0520017279169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF DSP ANXA3 AFAP1L1 FRY HMCN1 NR5A2

1.30e-05200172786ec951234015ced7126b016199e5869a0f22478
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

ABCA1 FBLN5 DYNC2H1 ACTN2 NR2F1 DST ADAMTS15

1.30e-052001727a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

VWF ACTN1 NR2F2 PGM5 HMCN1 NFIA PLEC

1.30e-052001727e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF DSP ANXA3 AFAP1L1 FRY HMCN1 NR5A2

1.30e-052001727061ba851f941c616ddb462512e826c412881c3ce
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_only / Treatment groups by lineage, cell group, cell type

ACTN1 NR2F2 PTK2 FAT1 ARHGEF7 AK5 ATP1B2

1.30e-0520017277c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCellAT1-AT2_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DDR1 DSP TMPRSS4 DHX8 FAT1 XKRX

3.47e-0515817263bc51cfd37b289cc3e866b54ce55a298e5eff690
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN5 NT5DC3 NR2F1 ASPM KYAT3 SORL1

3.86e-0516117269f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EPHB6 TEKT5 PTK2 MCTP1 NFIA SLIT1

4.00e-05162172658da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X

SPTLC3 CHRDL2 NR2F1 MROH7 MTBP BRSK1

4.13e-051631726961c3a1303108afd680365466045f3460a30a7b0
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN5 VWF ANXA3 NR2F2 PGM5 HMCN1

5.06e-05169172658136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN5 VWF ANXA3 NR2F2 PGM5 HMCN1

5.06e-05169172604c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF ACTN2 NR2F1 NR2F2 PGM5 AFAP1L1

5.23e-0517017264848965bc7e9356c6601bb41eeea1553d2eea87e
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN5 VWF RILP PGM5 DST GABRA1

5.23e-051701726af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MKKS VWF MYO15B CORO2B NR5A2 NAIF1

5.40e-0517117261ae4b6a25bc9c1065cf5d95998ebcc70aee21ab5
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN5 VWF RILP PGM5 DST GABRA1

5.58e-0517217269a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DDR1 GALK1 TEX2 ABCA5 XKRX MUC5AC

5.76e-0517317264f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR2F6 TMPRSS4 YRDC ADGRF4 TNFAIP3 NAIF1

5.76e-0517317260f9c1d3298e59e6d22bb3306f0f445f490be8bbd
Drugarachidonyl trifluoromethyl ketone; Up 200; 10uM; MCF7; HG-U133A

TSNAXIP1 NR2F6 ACTN1 ERN2 NR2F2 NADK AFF1 KYAT3 ZER1 PLEC KPNB1

2.91e-0719517211327_UP
DrugCDRI-85/287

NR2F6 NR2F1 NR2F2 OSBPL9 OSBPL11

2.38e-06291725CID000159508
DrugAminohippuric acid [61-78-9]; Down 200; 20.6uM; HL60; HT_HG-U133A

PRKD2 NR2F6 ABCA1 SLC9A8 ANXA3 CEP290 ACTN1 PITPNM1 NADK MFN2

2.54e-06196172103076_DN
Drugsodium molybdate

NR2F6 CCT4 NR2F1 NR2F2 OSBPL9 OSBPL11

4.49e-06571726CID000061424
DrugAC1Q6PCP

NR2F6 NR2F1 NR2F2 DST OSBPL9 OSBPL11 TNFAIP3 PLEC KLK2 WNK4

1.05e-0523017210CID000005267
Drug0316684-0000 [391209-55-5]; Up 200; 10uM; PC3; HT_HG-U133A

ABCA1 SMCHD1 PTER TRRAP NR2F2 ABCA5 PAK2 PLEC CYB5R1

1.68e-0519317297098_UP
DrugQuercetine dihydrate [6151-25-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

GALK1 TEX2 NR2F2 PTK2 SLC44A1 ABCA5 PAK2 PLEC MVK

1.68e-0519317294846_DN
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A

TSNAXIP1 ABCA1 SLC9A8 NLRX1 CEP290 GSAP TBC1D8 DNAAF1 SORL1

1.75e-0519417297001_UP
DrugCocaine

EPHB3 EPHB6 TRPC4AP GALK1 VWF COL15A1 RIPK1 DSP CES1 CEACAM3 SPACA9 ACTN2 NR2F2 PTK2 SLC44A1 ABCA5 ARHGEF7 NFIX LRRC27 PLEC ATP1B2 DNAH8 GABRA1 SORL1 KPNB1

1.90e-05131417225ctd:D003042
DrugEstrone [53-16-7]; Up 200; 14.8uM; MCF7; HT_HG-U133A

SPTLC3 NXPE4 ERN2 NR2F1 PITPNM1 EXD3 ARR3 AFF1 PLEC

1.97e-0519717294993_UP
DrugFenofibrate [49562-28-9]; Down 200; 11uM; MCF7; HT_HG-U133A

DYNC2H1 ABCF2 NT5DC3 NR2F1 SIK2 TNFAIP3 PLEC DNAAF1 MVK

2.06e-0519817297474_DN
Drugrapamycin; Up 200; 0.1uM; MCF7; HG-U133A

TSNAXIP1 ABI1 ACTN1 NR2F2 SIK2 NADK AFF1 KYAT3 ZER1

2.14e-051991729326_UP
DrugImplanon

NR2F6 NR2F1 NR2F2 OSBPL9 OSBPL11

2.75e-05471725CID000040976
Diseasefocal segmental glomerulosclerosis 1 (implicated_via_orthology)

ACTN4 ACTN1 ACTN2 ACTN3

4.93e-0951674DOID:0111128 (implicated_via_orthology)
DiseaseCiliopathies

MKKS DYNC2H1 CEP290 BBS1 ARL13B DNAAF1 DNAH8

3.20e-061101677C4277690
DiseaseBardet-Biedl syndrome 1 (disorder)

MKKS CEP290 BBS1

1.14e-04171673C2936862
DiseaseBardet-Biedl syndrome

MKKS CEP290 BBS1

1.36e-04181673cv:C0752166
Diseasepulmonary fibrosis (biomarker_via_orthology)

VWF MFN2 B3GAT1 MUC5AC

1.86e-04501674DOID:3770 (biomarker_via_orthology)
DiseaseDisorder of eye

MKKS CEP290 BBS1 PRPF8 ARL13B MFN2 TRPM1

2.15e-042121677C0015397
Diseasehereditary sensory neuropathy (implicated_via_orthology)

CCT4 DST

3.15e-0451672DOID:0050548 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

NR2F6 VWF DYNC2H1 SMC6 APOL1 HELQ NR2F1 RIF1 NLRP14 CLCN1 MROH7 OSBPL11 AFF1 UTP20 ADGRF4 SORL1

4.15e-04107416716C0006142
Diseasetrefoil factor 1 measurement

TMPRSS4 MUC5AC

4.71e-0461672EFO_0021865
DiseaseSchizophrenia

CACNA1C DDR1 ABCA1 TEKT5 TRRAP AQP4 NDUFS1 ADCY7 PITPNM1 PAK2 B3GAT1 ADGRF4 TRPM1 GABRA1

5.24e-0488316714C0036341
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

ARHGAP24 ACTN4 APOL1

6.46e-04301673C1868672
DiseaseHereditary Autoinflammatory Diseases

TNFAIP3 MVK

6.56e-0471672C0751422
Diseaseepidermolysis bullosa simplex (is_implicated_in)

DST PLEC

6.56e-0471672DOID:4644 (is_implicated_in)
DiseaseOvarian Mucinous Adenocarcinoma

EPHB6 TRRAP WNK4

7.12e-04311673C1335167
Diseasepantothenate measurement

ABCA1 CAD

8.72e-0481672EFO_0021034
DiseaseSudden Cardiac Death

CACNA1C DSP

8.72e-0481672C0085298
DiseaseAutoinflammatory disorder

POLA1 TNFAIP3 MVK

1.02e-03351673C3860213
DiseaseFocal glomerulosclerosis

ARHGAP24 ACTN4 APOL1

1.11e-03361673C0017668
DiseaseMental deterioration

CACNA1C SORL1

1.12e-0391672C0234985
DiseaseMild cognitive disorder

CACNA1C SORL1

1.12e-0391672C1270972
Diseaseosteoarthritis, hand

SNAP47 C12orf60 DNAH8

1.20e-03371673EFO_1000789
DiseaseAnemia, Sickle Cell

CACNA1C CAD

1.39e-03101672C0002895
DiseaseInherited focal segmental glomerulosclerosis

ACTN4 APOL1

1.39e-03101672cv:CN327126
Diseasearrhythmogenic right ventricular cardiomyopathy (is_implicated_in)

DSP ACTN2

1.39e-03101672DOID:0050431 (is_implicated_in)
Diseasebone morphogenetic protein 7 measurement

CHRDL2 BMP6

1.39e-03101672EFO_0020187
DiseaseFocal segmental glomerulosclerosis

ACTN4 APOL1

1.39e-03101672cv:C0017668
DiseaseQRS duration

DDR1 TRPC4AP ARHGAP24 CES1 ACTN2 HMCN1 NFIA

1.60e-032981677EFO_0005055
DiseaseHereditary Nephrotic Syndromes, Autosomal Dominant

ACTN4 APOL1

1.69e-03111672cv:CN043612
Diseasechronic musculoskeletal pain

RNF123 EXD3

2.02e-03121672EFO_0022195
DiseaseCharcot-Marie-Tooth disease (is_implicated_in)

FBLN5 MFN2

2.02e-03121672DOID:10595 (is_implicated_in)
DiseaseGastric Adenocarcinoma

PRKD2 TRRAP BRSK1

2.12e-03451673C0278701
Diseasesunburn

CEP290 ADAM30 TPRG1 TRPM1

2.19e-03961674EFO_0003958
DiseaseColorectal Carcinoma

EPHB6 ABCA1 CAD KMT2C BMP6 FAT1 CORO2B ABCA5 ADAMTS15 DNAH8 SORL1

2.27e-0370216711C0009402
DiseaseFamilial idiopathic steroid-resistant nephrotic syndrome

ACTN4 APOL1

2.38e-03131672cv:C4273714
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

ABCA1 SMC6 ZER1 KPNB1

2.45e-03991674EFO_0004611, EFO_0007878
Diseasenon-high density lipoprotein cholesterol measurement

ABCA1 GALK1 HMGXB4 SMC6 BBS1 TBC1D8 NFIA OSBPL9 AFF1 NAIF1 KPNB1

2.56e-0371316711EFO_0005689
Diseasehepatocellular carcinoma (implicated_via_orthology)

CAD PTK2 MCM9

2.71e-03491673DOID:684 (implicated_via_orthology)
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

ABCA1 SMC6 ZER1 KPNB1

2.73e-031021674EFO_0004329, EFO_0004611
DiseaseBardet-Biedl syndrome (is_implicated_in)

MKKS BBS1

2.77e-03141672DOID:1935 (is_implicated_in)
DiseaseImpaired cognition

CACNA1C SORL1

2.77e-03141672C0338656
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

NR2F6 NR2F1 NR2F2 AFF1

3.04e-031051674DOID:9352 (implicated_via_orthology)
Diseasecancer biomarker measurement

PPIP5K1 KLK2

3.19e-03151672EFO_0005127
Diseaseglycerate measurement

MCTP1 HMCN1

3.19e-03151672EFO_0021029
DiseaseMetastatic melanoma

PTK2 BRSK1 WNK4

3.57e-03541673C0278883
Disease5-oxoproline measurement

LRRC4C DNAH8

3.63e-03161672EFO_0010988
Diseaseidiopathic scoliosis (implicated_via_orthology)

PPP2R3B DNAAF1

3.63e-03161672DOID:0060250 (implicated_via_orthology)
Diseaseimmature platelet fraction

PPP4R1 VWF ACTN1 PLEC

4.08e-031141674EFO_0009187
DiseaseHypertrophic Cardiomyopathy

CACNA1C DSP NDUFS1

4.16e-03571673C0007194
DiseasePolydactyly

MKKS DYNC2H1 CEP290 BBS1

4.47e-031171674C0152427
DiseaseAge-related macular degeneration

FBLN5 HMCN1

4.59e-03181672cv:C0242383
Diseaseimmature platelet measurement

PPP4R1 VWF ACTN1 PLEC

4.75e-031191674EFO_0803541
Diseasegout

PRKD2 ABCA1 ACAD10 FAT1 DST

5.26e-031961675EFO_0004274
Diseasefree androgen index

DDR1 NR2F6 SMCHD1 TMPRSS4 NFIA MCM9 KPNB1

5.59e-033741677EFO_0007005
Diseasecoagulation factor measurement

VWF ASPM

5.66e-03201672EFO_0004634
DiseaseFamilial aplasia of the vermis

CEP290 ARL13B

5.66e-03201672cv:C0431399

Protein segments in the cluster

PeptideGeneStartEntry
LLRTLPMGKAQEVSI

URB2

766

Q14146
IGLMIILIESFPKSL

ABCA5

341

Q8WWZ7
MPKRRDILAIVLIVL

B3GAT1

1

Q9P2W7
GTEKPLPVDMVLISL

AQP4

61

P55087
TVIDGMLLLKTPEEL

CES1

321

P23141
MLLSAIGKREVPIPE

ABCF2

126

Q9UG63
MTISPDGKTLVILRV

CEACAM18

181

A8MTB9
SPELMKVLQDTLGRR

AVIL

216

O75366
MLLLEVISGERLAKP

ACTN1

66

P12814
KLMLLLEVISGERLP

ACTN2

71

P35609
MSRLKDPNIIRLLGV

DDR1

676

Q08345
ERVLRSNMDILKPIL

ABCA1

226

O95477
MRISKNVAILTPLLG

ADGRF4

601

Q8IZF3
GLKLMLLLEVISGER

ACTN4

81

O43707
IRGIGTDEKMLISIL

ANXA3

31

P12429
VLLVPMDTPGIKIIR

ACAD10

856

Q6JQN1
MLLEEEIPSGKRALI

ABI1

6

Q8IZP0
ILVLTTGLSKPFMRL

ARHGEF7

396

Q14155
REPVRKVTLLMVGLD

ARL13B

16

Q3SXY8
DIGTIMRVVELSPLK

DOT1L

286

Q8TEK3
FLRMSLEPKVVLLTV

ADCY7

736

P51828
REVRGLMDTIVPEKI

CCDC180

151

Q9P1Z9
TLISPRGMKLVEILQ

BVES-AS1

76

Q5T3Y7
TPLKEGRVREIMTFL

ASPM

111

Q8IZT6
TIIRPGMDKELLGIL

ARR3

301

P36575
LEPLTVEVLSVGKMT

ADAMTS15

776

Q8TE58
PIMKVLSIRGLVILA

MROH7

1016

Q68CQ1
LVMVILFKGIPLEST

NFIA

131

Q12857
LVGKTPIETLIRDML

NR2F6

376

P10588
MLDLVKPRTEGKITL

PPP2R3B

441

Q9Y5P8
RVPGLLLEAMKVAVR

RILP

281

Q96NA2
KTPIETLIRDMLLSG

NR2F1

396

P10589
LVGKTPIETLIRDML

NR2F2

386

P24468
QVRLGMDLTKVVLPT

OSBPL9

381

Q96SU4
MDLTKVVLPTFILER

OSBPL9

386

Q96SU4
LLTGPSQLKIRIDAM

PGM5

216

Q15124
VPLKVSAELLMSIRL

PAXIP1

816

Q6ZW49
LLERVLMKDIVTPVP

CADPS

816

Q9ULU8
TGMLKILSPLDRETT

FAT1

771

Q14517
VLREMKAIGIEPSLA

PTCD3

356

Q96EY7
LKLVIEAGLIPRMVE

KPNA7

106

A9QM74
LMLLRLSEPAKITDV

KLK2

121

P20151
IAIDRIGVTLMEPLT

MKKS

311

Q9NPJ1
LVMVILFKGIPLEST

NFIX

131

Q14938
KLVMESVTLPLETLV

KMT2C

686

Q8NEZ4
FKMTIPLLVRQIEGL

LONP2

211

Q86WA8
IVSITLIEGRDLKAM

MCTP1

471

Q6DN14
DRPKFGLLMVVLSLI

MAGEL2

1106

Q9UJ55
VPILEDTLMRILVIG

INTS1

646

Q8N201
PSGIVLELLKEAMVA

AK5

436

Q9Y6K8
ALSVLIQVLRPMIKD

NAIF1

281

Q69YI7
LVEKELMVSVLGPLS

DST

4641

Q03001
SLLERKQVRPMLLVD

HDHD2

81

Q9H0R4
GLMIRPKTENLDVIV

ATP1B2

81

P14415
KVVARDLVGAMLSPL

ERN2

751

Q76MJ5
RPIVVPAGVELKIML

NADK

356

O95544
EITQGLISVMKRELP

DNAH8

2911

Q96JB1
ALELMTVLVGSPRKD

GALK1

56

P51570
KITLVDIELIAAMGP

DNAH12

1996

Q6ZR08
EMILSSEKGRLPERL

PRKD2

636

Q9BZL6
RLEGVVTKSRPVMIL

EPHB3

696

P54753
MPNKLLRITEDGTLL

GABRA1

141

P14867
ELLTLPVLMKRSITA

TUBGCP6

1476

Q96RT7
IPGIDEVMKTTKIII

LRRC4C

516

Q9HCJ2
PTLSRVLMKVDGVVI

MUC5AC

131

P98088
TDLPIKLRLIDTLRM

PSMD12

116

O00232
TLTLREPDGLKMKLI

HMGXB4

181

Q9UGU5
EDVSLVLGIMAKLLP

NLRX1

531

Q86UT6
MVPEVRVLSSLLGLA

CHRDL2

1

Q6WN34
ESKTIMLRGLPITIT

RBM5

96

P52756
MLRGLPITITESDIR

RBM5

101

P52756
LEMGILPREIRKLVE

POLA1

906

P09884
DMIDGLKPLLPVSVR

MFN2

496

O95140
MSIGAIKIALEISLP

HMCN1

121

Q96RW7
ILTNVVPKMLLRGIT

PTER

316

Q96BW5
VPKMLLRGITENVLD

PTER

321

Q96BW5
QLGVLPALKIVMIRD

PPP4R3C

361

Q6ZMV5
RIVKFVAVGSPLLLM

PANX3

36

Q96QZ0
GRLEIPAELAVMLKT

MYO15B

426

Q96JP2
DIGLATTIMPKILAI

OR56B4

76

Q8NH76
EIMEKLRTIVSIGDP

PAK2

231

Q13177
ILRPKVEDPLTIMEG

ARHGAP24

296

Q8N264
PTISKELMLERETLL

DYNC2H1

431

Q8NCM8
GITLVTEDIALPLMK

GSAP

501

A4D1B5
LLVPTMLLKSLGEDV

ADAM30

16

Q9UKF2
LETILVETKIMSPLG

CACNA1C

601

Q13936
VETKIMSPLGISVLR

CACNA1C

606

Q13936
LKGLIEPISMIVPRR

CORO2B

346

Q9UQ03
EALRERVGLEPKTMI

CEP290

501

O15078
SIMVPERTAKGTLLL

CDHR3

351

Q6ZTQ4
GLETLLNIPIKRTMI

DSP

971

P15924
KREMQKEILSVLGLP

BMP6

76

P22004
KETRLTLMEEVLLLG

GOLPH3

56

Q9H4A6
ILEMSRGVKLTDVAP

APOL1

326

O14791
RTILKIPMNELTTIL

CENPN

11

Q96H22
MPLSVAEGKEVLLLV

CEACAM3

41

P40198
LLRGMIEVEPEKRLS

BRSK1

261

Q8TDC3
PTLIELMKDPSVVVR

KPNB1

411

Q14974
EILSILESMPDLRVL

DNAAF1

236

Q8NEP3
GSFIITLVKIPRMIL

SLC44A1

446

Q8WWI5
VLLKQLVPLMRLESI

FRY

966

Q5TBA9
MPGIKRILTVTILAL

FBLN5

1

Q9UBX5
VKAELIPLMEVTGVL

HELQ

1006

Q8TDG4
RIDPLTLKEMLESIR

BBS1

146

Q8NFJ9
AILTEDIPLERLMGK

COL15A1

866

P39059
PLKLLIMSATLRVED

DHX37

401

Q8IY37
GVVSLIPLILDLMKE

SPACA9

136

Q96E40
DRMVRLLESVGLKPI

KYAT3

351

Q6YP21
RMKSLGPDVPELIIL

DHX8

796

Q14562
PGRAMVDIILLLSDK

MTBP

161

Q96DY7
QLKLGMDLTRVVLPT

OSBPL11

376

Q9BXB4
MDLTRVVLPTFILEK

OSBPL11

381

Q9BXB4
LSVGSIPRSMKVILE

MCM9

211

Q9NXL9
RGRLVMLPKVETEAL

NR5A2

36

O00482
ILSRKLLVPEIDEVM

UTP20

2231

O75691
RMPILSKESAPGLII

SORL1

491

Q92673
NLKLIEEKLGMTPIR

SMCHD1

1951

A6NHR9
EEISLPALRSIRLKM

TDRD6

471

O60522
APMVGKDITERLILP

PPP4R1

201

Q8TF05
GVDLLVEILMRPTIS

TRPC4AP

136

Q8TEL6
VEILMRPTISIRGQK

TRPC4AP

141

Q8TEL6
RLISAKMPEVIPILE

SNAP47

326

Q5SQN1
IKMLPVELGSVTTLK

LRRC27

126

Q9C0I9
LLLRSPDTMVIIKTE

NXPE4

461

Q6UWF7
LMVRGVQELLLKLLP

MTCP1

91

P56278
RLTEPMVRNEKGLLT

NDUFS1

301

P28331
KIIRALSEIAGMTLP

NDUFS1

621

P28331
IKEGMPITLTIRLIS

PLCZ1

476

Q86YW0
SKTLVLMEITIKGLP

RIF1

546

Q5UIP0
TGAIIPELRSELKIM

NT5DC3

406

Q86UY8
PDERIMELVLGKLAT

PRDM15

676

P57071
VPMVKEVGLALRTLL

PTK2

951

Q05397
ILRLEGVVTKSRPLM

EPHB6

731

O15197
LLDMVDLERRLKTTP

HDHD5

166

Q9BXW7
MLVLDPSKRLTIAQI

SIK2

251

Q9H0K1
PMEKRQLIGTTTIVI

SLC9A8

441

Q9Y2E8
LEKGIEILTDMSRPV

CCT4

141

P50991
LLERSIMAKEGPLKV

TEKT5

376

Q96M29
EIAALAPSMLKIRII

POTEI

1016

P0CG38
PIAEQIIRSLKLIMG

SPTLC3

406

Q9NUV7
PILKEIVEMLFSRGL

SKIV2L

641

Q15477
TGITPMLQLIRAILK

CYB5R1

186

Q9UHQ9
AEMSTPLSVKGRIIL

RIPK1

106

Q13546
GLKLMLLLEVISGER

ACTN3

76

Q08043
LLLVEMGSRVTPEAL

AFAP1L1

506

Q8TED9
LMVKITLDLLSRIPQ

AFF1

761

P51825
LEQIVKAMGPILEIL

C12orf60

211

Q5U649
IPEMKTILRGVVLKE

CLCN1

191

P35523
TPMEIVVDIFRKLGL

CLCN3

766

P51790
SIISMLKQRREPLIL

ZNF610

71

Q8N9Z0
IIVTRKGMLDPLEVH

PRPF8

1861

Q6P2Q9
GLVLALRKTVMPALE

PITPNM1

701

O00562
LIKEGGMPLLRDIIK

ZER1

721

Q7Z7L7
GLAGMLTEVLRKLTI

TTC30B

381

Q8N4P2
RIDLAVLLGKTPSTM

UBAP2L

281

Q14157
KIDRPEASRITLLLM

VWF

1371

P04275
VTVPKMLEGLLLERK

OR4E2

76

Q8NGC2
PIIVISDKMLRSLES

TNFAIP3

206

P21580
TTKDTPKLGLLMVIL

TRO

526

Q12816
RLTEIGPRMTLQLIK

PPAN

271

Q9NQ55
MLSEVLLVSAPGKVI

MVK

1

Q03426
LLRVLEMTITLVPEI

RNF123

1081

Q5XPI4
EKIRKLVAMGIPESL

TBC1D8

496

O95759
GKKLMVLTEPILIET

TPRG1

236

Q6ZUI0
METFRKVGIPIIIAL

TMPRSS4

26

Q9NRS4
ISPLLSVKELRDMGI

SCFD1

56

Q8WVM8
SLIDMRGIETVLLIK

SMC6

601

Q96SB8
PIKGLKLTVEEAVRM

PLEC

4116

Q15149
MTSQKLVRLPGLIDV

CAD

1456

P27708
LALEKIREILMSEPG

TRPM1

871

Q7Z4N2
TLTELDMGVAVPKIL

TEX2

866

Q8IWB9
EEVTLPKLRGGLMTI

TSNAXIP1

581

Q2TAA8
SLISAEVPLGRVVLM

XKRX

191

Q6PP77
MTEIRLELNGIKSIP

SLIT1

311

O75093
ILRVIEILIEKMPTD

WDR7

1306

Q9Y4E6
SLKVLAELPIIVVLM

TRRAP

221

Q9Y4A5
IQRVETLLKRDTGPM

WNK4

741

Q96J92
LEGELTPILVQMVKS

PPIP5K1

596

Q6PFW1
LKDLLPGPVTLVMER

YRDC

141

Q86U90
SLLRKVMLPEASLLV

NLRP14

291

Q86W24
IELKPLGMVSSIIEQ

NAF1

196

Q96HR8
SELGVEKMSIPLLLQ

EXD3

166

Q8N9H8