Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesssomatic sensory system development

ULK2 ULK1

8.93e-072202GO:0160038
GeneOntologyBiologicalProcessnegative regulation of collateral sprouting

ULK2 ULK1

5.86e-0512202GO:0048671
GeneOntologyBiologicalProcessregulation of protein complex stability

TRAPPC11 WASHC4

9.31e-0515202GO:0061635
GeneOntologyBiologicalProcesspiecemeal microautophagy of the nucleus

ULK2 ULK1

1.35e-0418202GO:0034727
GeneOntologyBiologicalProcessreticulophagy

ULK2 ULK1

1.86e-0421202GO:0061709
GeneOntologyBiologicalProcessnucleophagy

ULK2 ULK1

2.23e-0423202GO:0044804
GeneOntologyBiologicalProcessmicroautophagy

ULK2 ULK1

2.43e-0424202GO:0016237
GeneOntologyBiologicalProcessregulation of collateral sprouting

ULK2 ULK1

2.64e-0425202GO:0048670
GeneOntologyBiologicalProcesscollateral sprouting

ULK2 ULK1

5.83e-0437202GO:0048668
GeneOntologyCellularComponentphagophore assembly site membrane

ULK2 ULK1

2.19e-0422212GO:0034045
GeneOntologyCellularComponentphagophore assembly site

ULK2 ULK1

6.96e-0439212GO:0000407
DomainSer/Thr_kinase_C

ULK2 ULK1

1.09e-062202IPR022708
DomainDUF3543

ULK2 ULK1

1.09e-062202PF12063
DomainSer/Thr_kin_STPK_Ulk-1/2

ULK2 ULK1

1.09e-062202IPR016237
DomainCa/CaM-dep_Ca-dep_prot_Kinase

ULK2 ULK1

2.45e-0369202IPR020636
DomainPDZ

APBA1 MYO18A

9.84e-03141202PF00595
DomainPDZ

APBA1 MYO18A

1.08e-02148202SM00228
Domain-

APBA1 MYO18A

1.11e-021502022.30.42.10
DomainPDZ

APBA1 MYO18A

1.12e-02151202PS50106
DomainPDZ

APBA1 MYO18A

1.14e-02152202IPR001478
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

APBA1 GRM5 DLGAP1

1.65e-0556133M27616
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

APBA1 GRM5 DLGAP1

6.21e-0587133M27617
PathwayWP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_AUTOPHAGY

ULK2 ULK1

1.33e-0419132M39903
PathwayWP_NANOPARTICLE_TRIGGERED_AUTOPHAGIC_CELL_DEATH

ULK2 ULK1

1.96e-0423132M39325
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

GRM5 DLGAP1

3.83e-0432132MM15326
PathwayKEGG_REGULATION_OF_AUTOPHAGY

ULK2 ULK1

4.59e-0435132M6382
PathwayWP_TARGET_OF_RAPAMYCIN_SIGNALING

ULK2 ULK1

4.86e-0436132M39635
PathwayKEGG_MTOR_SIGNALING_PATHWAY

ULK2 ULK1

1.01e-0352132M7561
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

GRM5 DLGAP1

1.68e-0367132MM15327
PathwayPID_MTOR_4PATHWAY

ULK2 ULK1

1.78e-0369132M121
PathwayREACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS

TRAPPC11 ULK1

3.00e-0390132M27779
PathwayREACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS

TRAPPC11 ULK1

3.07e-0391132MM15518
PathwayREACTOME_NEURONAL_SYSTEM

APBA1 GRM5 DLGAP1

3.19e-03335133MM14503
PathwayWP_P53_TRANSCRIPTIONAL_GENE_NETWORK

ULK2 ULK1

3.41e-0396132M40062
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

GRM5 DLGAP1 ULK1

4.12e-03367133M48346
PathwayREACTOME_RAB_REGULATION_OF_TRAFFICKING

TRAPPC11 ULK1

5.10e-03118132MM15589
PathwayREACTOME_RAB_REGULATION_OF_TRAFFICKING

TRAPPC11 ULK1

5.44e-03122132M27872
PathwayREACTOME_NEURONAL_SYSTEM

APBA1 GRM5 DLGAP1

5.66e-03411133M735
Pubmed

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51.

ULK2 ULK1

3.47e-0722129600096
Pubmed

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).

ULK2 ULK1

3.47e-07221230782972
Pubmed

Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes.

ULK2 ULK1

3.47e-07221224135897
Pubmed

The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy.

ULK2 ULK1

3.47e-07221221460635
Pubmed

Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle.

ULK2 ULK1

3.47e-07221234658916
Pubmed

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons.

ULK2 ULK1

3.47e-07221210624947
Pubmed

Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes.

ULK2 ULK1

3.47e-07221233149253
Pubmed

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.

ULK2 ULK1

3.47e-07221223291478
Pubmed

ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.

ULK2 ULK1

3.47e-07221227153534
Pubmed

Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function.

ULK2 ULK1

1.04e-06321235104184
Pubmed

An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.

ULK2 ULK1

1.04e-06321237846507
Pubmed

Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer.

ULK2 ULK1

1.04e-06321239213022
Pubmed

Long non‑coding RNA growth arrest‑specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer.

ULK2 ULK1

1.04e-06321232705220
Pubmed

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.

ULK2 ULK1

1.04e-06321226213203
Pubmed

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer.

ULK2 ULK1

1.04e-06321232516362
Pubmed

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases.

ULK2 ULK1

1.04e-06321221690395
Pubmed

ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.

ULK2 ULK1

2.08e-06421230979586
Pubmed

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.

ULK2 ULK1

2.08e-06421218443221
Pubmed

Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.

ULK2 ULK1

2.08e-06421225925668
Pubmed

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death.

ULK2 ULK1

2.08e-06421221475306
Pubmed

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma.

ULK2 ULK1

3.47e-06521232203415
Pubmed

The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.

ULK2 ULK1

3.47e-06521227203176
Pubmed

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death.

ULK2 ULK1

3.47e-06521222493260
Pubmed

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.

ULK2 ULK1

3.47e-06521236608143
Pubmed

Atg101, a novel mammalian autophagy protein interacting with Atg13.

ULK2 ULK1

3.47e-06521219597335
Pubmed

Role of Unc51.1 and its binding partners in CNS axon outgrowth.

ULK2 ULK1

5.20e-06621215014045
Pubmed

Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway.

ULK2 ULK1

5.20e-06621226371245
Pubmed

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.

ULK2 ULK1

5.20e-06621227046250
Pubmed

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.

ULK2 ULK1

5.20e-06621218936157
Pubmed

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.

ULK2 ULK1

5.20e-06621219225151
Pubmed

Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.

ULK2 ULK1

5.20e-06621217389358
Pubmed

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.

ULK2 ULK1

7.28e-06721228877469
Pubmed

Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.

ULK2 ULK1

7.28e-06721228389568
Pubmed

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.

ULK2 ULK1

1.25e-05921226649827
Pubmed

ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.

ULK2 ULK1

1.90e-051121223043107
Pubmed

WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.

ULK2 ULK1

2.28e-051221224954904
Pubmed

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.

ULK2 ULK1

2.70e-051321221795849
Pubmed

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

GRM5 DLGAP1

3.15e-051421221795692
Pubmed

A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.

APBA1 DLGAP1

4.70e-051721220808911
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DENND11 UBR5 ULK2 ULK1

9.45e-0540721412693553
Pubmed

Analysis of a lung defect in autophagy-deficient mouse strains.

ULK2 ULK1

1.12e-042621224275123
Pubmed

The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.

ULK2 ULK1

1.60e-043121229099309
Pubmed

Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.

ULK2 ULK1

1.81e-043321222904094
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

GRM5 UBR5 DLGAP1

4.49e-0425121327507650
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

APBA1 MYO18A GRM5 DLGAP1 SERPINB6

4.90e-04113921536417873
Pubmed

Global phosphoproteome of HT-29 human colon adenocarcinoma cells.

MYO18A UBR5

5.82e-045921216083285
InteractionSYNGAP1 interactions

GRM5 UBR5 ULK2 DLGAP1 ULK1

1.02e-05307205int:SYNGAP1
Cytoband8q22

UBR5 MATN2

2.08e-05152128q22
CytobandEnsembl 112 genes in cytogenetic band chr8q22

UBR5 MATN2

2.67e-03168212chr8q22
GeneFamilyAutophagy related

ULK2 ULK1

3.82e-04331621022
GeneFamilyPDZ domain containing

APBA1 MYO18A

7.80e-031521621220
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF236 BNC2 SCRT1

2.37e-0271816328
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#2_top-relative-expression-ranked_500

BNC2 MATN2 SERPINB6

1.31e-0552193gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k2_500
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#3_top-relative-expression-ranked_500

BNC2 MATN2 SERPINB6

2.12e-0561193gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k3_500
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

APBA1 GRM5 BNC2 DLGAP1

1.17e-0617221436a96714a0eb6ac438648135336c9791881ddadb
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

MYO18A DENND11 DLGAP1

5.71e-05161213347edb0de10850b7d16c40945751033289289c9b
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRM5 BNC2 DLGAP1

6.47e-05168213a086c306be430adf0632ba53e98cd8014d2de330
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ULK2 TRAPPC11 MATN2

6.82e-051712136a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ULK2 TRAPPC11 MATN2

6.82e-051712139be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 TIMM23B ACSF2

6.82e-05171213f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCellmetastatic_Brain-B_lymphocytes-Undetermined|B_lymphocytes / Location, Cell class and cell subclass

NME7 SLC6A16 BNC2

6.82e-051712130d14bc9688c427ba2265984987dc3eea195b19eb
ToppCellfacs-Large_Intestine-Proximal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO18A NME7 ACSF2

7.06e-0517321399532bb768ee35fed939a377acb5215d3f8904bd
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO18A NME7 ACSF2

7.06e-05173213e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRM5 BNC2 DLGAP1

7.68e-05178213544379f5a6145429762258d426b876bb36c112f5
ToppCellCOVID-19-kidney-Epi_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

APBA1 GRM5 BNC2

7.81e-05179213e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 DLGAP1 ACSF2

8.07e-051812139542c19edc9bd2cba68c01c2a8407705398e3011
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 DLGAP1 ACSF2

8.07e-051812138f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCellfacs-Heart-LV-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO18A ULK2 WASHC4

8.21e-051822136dff753d65ba45db81f3cc0c9f59e1779d490955
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APBA1 DLGAP1 MATN2

8.61e-05185213ca69499ba8c39b7ed6717d05685d6f70066a77bd
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BNC2 DLGAP1 MATN2

8.61e-051852139f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 DLGAP1 ACSF2

9.18e-0518921313fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 DLGAP1 ACSF2

9.18e-05189213204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 DLGAP1 ACSF2

9.47e-051912133c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 DLGAP1 ACSF2

9.47e-051912131c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Hpcal4_(Substantia_Innominata_(SI))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC6A16 BNC2

1.85e-0443212ba1a8fd3119a26b65722898276045bf5ecf59768
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Hpcal4_(Substantia_Innominata_(SI))--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC6A16 BNC2

1.85e-044321205de4f11e7315dce19efed14605d7e1704d61b3a
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Hpcal4_(Substantia_Innominata_(SI))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC6A16 BNC2

1.85e-0443212f1e6e1c386851e773f8aa44f112ebf7fdb887df1
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 DLGAP1

1.55e-03125212b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

BNC2 ACSF2

1.78e-03134212b959899c89d3a0363a3cd2309155280e0fe5ba88
ToppCellLPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRM5 DLGAP1

1.83e-03136212a2063abe2d7c3277bfbe1514c8c66363cf04b248
ToppCell368C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MATN2 ULK1

1.91e-031392124efab4421e3448880a1dcf981f6a65131b038010
ToppCell368C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MATN2 ULK1

1.91e-0313921239f3c28f89c37bb8cc049c56d2948ea906fb3d86
ToppCellHealthy-CD4+_T_activated|World / disease group, cell group and cell class

DENND11 DLGAP1

1.94e-03140212407691970ec72a3afb45e431cf48814546b8acff
ToppCellHealthy-CD4+_T_activated|Healthy / disease group, cell group and cell class

DENND11 DLGAP1

2.08e-0314521245e8089fdf7d6f69b383816d8945e39fba24c873
ToppCellBAL-Mild-Myeloid-TRAM-TRAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ULK2 ULK1

2.25e-0315121245392bb1c6358beff33da0ca84f7696fb5824f30
ToppCellBAL-Mild-Myeloid-TRAM-TRAM2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ULK2 ULK1

2.25e-031512123d861285c71abe220b19a069eb9876199c6c8f39
ToppCellP15-Epithelial-epithelial_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DLGAP1 MATN2

2.28e-0315221200d5503d462cfa009fb4cac79ecee11725a18b9a
ToppCellremission-unassigned|remission / disease stage, cell group and cell class

NME7 PDRG1

2.34e-031542124130769829b838cc8a075c87ff6c187f0f507f8b
ToppCellMild_COVID-19-Myeloid-TRAM2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

ULK2 ULK1

2.34e-03154212ab648f6b29eb9e499e46cbdbaf3c5cf6b94d1f64
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|GI_small-bowel / Manually curated celltypes from each tissue

SLC6A16 ULK2

2.37e-031552121c67f58ed79331addbc012dab0cb09a7f350aedb
ToppCell390C-Lymphocytic-NK_cells-NK_cell_E|390C / Donor, Lineage, Cell class and subclass (all cells)

MATN2 ULK1

2.37e-0315521298d8432739965dd1ab77c899cb6321f7f05eaa46
ToppCellremission-unassigned|World / disease stage, cell group and cell class

NME7 PDRG1

2.37e-03155212d81bec894381e3e2d6249a567e8108b8423e5c54
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|368C / Donor, Lineage, Cell class and subclass (all cells)

DENND11 ULK2

2.40e-0315621225b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

APBA1 BNC2

2.46e-03158212e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

APBA1 BNC2

2.46e-03158212d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

APBA1 MATN2

2.49e-031592127ed659163f45e0c4df4782997c0786900c8186c8
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Hippocampus / BrainAtlas - Mouse McCarroll V32

UBR5 SCRT1

2.56e-03161212b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCellHealthy_Control-Lymphoid-Plasma|Healthy_Control / Condition, Lineage, Cell class and cell subclass

MYO18A ULK1

2.62e-031632122913ccdd4613472cd82077d4993e1d9f8b223398
ToppCellHealthy_Control-Lymphoid-Plasma-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

MYO18A ULK1

2.62e-03163212b589ff57d58dcb215ee3b5a10d81f43e5752a196
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

APBA1 BNC2

2.71e-031662126a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCellSevere-B_memory-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SERPINB6 ACSF2

2.78e-0316821285a36e1b994a8fd2f589563f011913e4944dc1cd
ToppCellBronchial_Biopsy-Immune-Mast_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

MYO18A BNC2

2.78e-0316821245ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

APBA1 MYO18A

2.81e-03169212c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

APBA1 MYO18A

2.81e-03169212ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BNC2 MATN2

2.84e-031702121a568efcff9c39b3f709b55a05d24710450a2657
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BNC2 MATN2

2.84e-0317021266d41d794790e621d72ac37af995510537103c9c
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MATN2 WASHC4

2.84e-031702128465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|368C / Donor, Lineage, Cell class and subclass (all cells)

APBA1 MYO18A

2.88e-0317121226b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCellP07-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DLGAP1 MATN2

2.91e-031722128d6a2a0d5f63b09a5a304a77e600a647f87e9de4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 ACSF2

2.94e-031732128888434641ea554a9b62c436e87920378eef29cd
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

MYO18A ULK1

3.01e-0317521229fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BNC2 MATN2

3.01e-0317521259249c9e83952d7277010e7be3c779e26399eb5d
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

UBR5 MATN2

3.01e-03175212085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BNC2 MATN2

3.01e-03175212b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

MYO18A ULK1

3.04e-03176212d6e660df92a3d7dd5732171ee623763faf108476
ToppCellP15-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DLGAP1 MATN2

3.04e-03176212792f414f5092aba14260b8e16378e793a822498e
ToppCellSevere-B_memory-6|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SERPINB6 ACSF2

3.08e-03177212c4c3511782d5febd0c8b369eebe9355ad3c3bcf2
ToppCell3'-Adult-Appendix-Epithelial-epithelial_progenitor_cell-Stem_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BNC2 TRAPPC11

3.08e-0317721234458f1eb7f3b1fd0cb9904529c01a9ca2f15500
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NME7 MATN2

3.08e-031772126b4fe717928814dafcd13090b1c90ea973938c6d
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BNC2 MATN2

3.08e-031772123e149bff1f1b393a7abe98984e37981c8296f95d
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

MYO18A DENND11

3.08e-03177212e8ab340b20cd41554c3841fe980e078e878af35f
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 MATN2

3.11e-03178212ef490b45901b2e6dedb519540fa3ae4e4db3a9ba
ToppCelldroplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 MATN2

3.11e-031782123e8aacb27ed1a3c3978e21dddddd0828f8000692
ToppCell343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NME7 ULK2

3.11e-031782128151e5d73407fd9cba382b69a2bc707c81790c7f
ToppCelldroplet-Bladder-nan-24m-Epithelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 MATN2

3.15e-031792123d6bb3cfe89d60f2f00aead9341f9967e5313763
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 ACSF2

3.15e-0317921278fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCellCOPD-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

BNC2 MATN2

3.15e-03179212e816dd846a6918ec143b57a380c3a47ed073b66e
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 MATN2

3.15e-0317921202c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 ACSF2

3.18e-03180212f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

BNC2 DLGAP1

3.18e-03180212358923e4228035a3e90e2957392089219e90dcd7
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 DLGAP1

3.18e-031802129b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 DLGAP1

3.18e-0318021208ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 ACSF2

3.18e-031802121363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DLGAP1 MATN2

3.18e-031802121e819c5c87704ec6535dfeaae56561895e239d07
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

BNC2 DLGAP1

3.18e-03180212864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 DLGAP1

3.21e-031812129e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BNC2 DLGAP1

3.21e-0318121225915e2500430a902db37d79a749ce2990b69810
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RDH11 UBR5

3.21e-03181212d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BNC2 SCRT1

3.21e-031812127f99002a6411117cc2361334c7c9228e20c574b4
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

APBA1 DLGAP1

3.21e-03181212fc51468c74534b60b4e786bd512d0f1c5dc05de7
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RDH11 UBR5

3.21e-03181212e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

BNC2 MATN2

3.21e-031812122b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell10x5'-bone_marrow-Myeloid_Mac-Macrophage|bone_marrow / Manually curated celltypes from each tissue

ULK2 SERPINB6

3.21e-03181212d2aa5b53162fb5c4cbbedbd2cb4b2b614e8c4afa
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

APBA1 BNC2

3.21e-031812125f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

BNC2 DLGAP1

3.21e-031812129ede19228ba5c0668a9c06c915510b95585216ef
ToppCellHealthy-multiplets|World / disease group, cell group and cell class

APBA1 ACSF2

3.21e-03181212f8dbac3cd500cc8d80853312b00d124c27b8fd85
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

APBA1 BNC2

3.21e-03181212c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 MATN2

3.21e-031812120b1e7335648823b1d83bdfa878ccd44efe7bba9a
ToppCellHippocampus-Neuronal-Inhibitory|Hippocampus / BrainAtlas - Mouse McCarroll V32

UBR5 SCRT1

3.25e-03182212b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 MATN2

3.25e-0318221282ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 MATN2

3.25e-03182212a512863304fad80acaab60a8c6107eb7c9cbac99
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 MATN2

3.25e-03182212e3248d108b51c49ca2c978636e13017e23b53860
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 MATN2

3.25e-03182212d568a8aec7e27ce632e248baea2ccd0e8dd255ac
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 MATN2

3.25e-03182212e89cc30db8e5c77a8bbddd1d5a4b5af09f1ccd67
Diseaseresponse to opioid

GRM5 DLGAP1

8.61e-0461212EFO_0008541
Diseasesunburn

GRM5 BNC2

2.11e-0396212EFO_0003958
Diseasesuntan

GRM5 BNC2

2.43e-03103212EFO_0004279
Diseasetreatment-resistant hypertension

BNC2 DLGAP1

2.71e-03109212EFO_1002006
DiseaseOrganic Mental Disorders, Substance-Induced

NME7 GRM5

3.01e-03115212C0029231
DiseaseDrug Use Disorders

NME7 GRM5

3.01e-03115212C0013222
DiseaseDrug Dependence

NME7 GRM5

3.01e-03115212C1510472
DiseaseDrug habituation

NME7 GRM5

3.01e-03115212C0013170
DiseaseSubstance Dependence

NME7 GRM5

3.01e-03115212C0038580
DiseaseSubstance Use Disorders

NME7 GRM5

3.01e-03115212C0038586
DiseaseSubstance-Related Disorders

NME7 GRM5

3.01e-03115212C0236969
DiseasePrescription Drug Abuse

NME7 GRM5

3.01e-03115212C4316881
DiseaseDrug abuse

NME7 GRM5

3.01e-03115212C0013146
DiseaseSubstance abuse problem

NME7 GRM5

3.06e-03116212C0740858
Diseaseskin pigmentation measurement

GRM5 BNC2

4.24e-03137212EFO_0007009
DiseaseVertigo

NME7 GRM5

4.36e-03139212HP_0002321
Diseasemajor depressive disorder

GRM5 BNC2

5.39e-03155212MONDO_0002009
Diseasephysical activity measurement

GRM5 ULK2

1.30e-02245212EFO_0008002

Protein segments in the cluster

PeptideGeneStartEntry
EMHKCKVPGCNMMFS

BNC2

1061

Q6ZN30
DMCIYHAPSGVMTMG

DLGAP1

211

O14490
HCLGSVAGTMMCLMY

ACSF2

311

Q96CM8
DVMVCFGNMFIKMPH

PDRG1

56

Q9NUG6
SMAYGLHNMQMSLCP

GRM5

406

P41594
AVAHMKYMGKGSMTG

MATN2

721

O00339
PAVYSEKVMHMFKGC

MYO18A

451

Q92614
YMYPEMKITHPAGCM

DENND11

221

A4D1U4
AVGEIHMKTMPAAMY

APBA1

811

Q02410
HDMVTEMYSGPCVAM

NME7

296

Q9Y5B8
MMCPYSKTADGFEMH

RDH11

131

Q8TC12
FVTMMVHLCMKPITY

SLC6A16

626

Q9GZN6
TCGKVYVSMPAMAMH

SCRT1

226

Q9BWW7
PMSMSCALAMVYMGA

SERPINB6

31

P35237
YKCPRMKSHLMVQMG

TRAPPC11

446

Q7Z392
GTMTGMLYKCTVSEM

TIMM23B

161

Q5SRD1
HSNMMAATLCGSPMY

ULK2

166

Q8IYT8
HYMFSALRDCVPAMM

WASHC4

631

Q2M389
HMATHMSMKPYKCPF

ZNF236

1041

Q9UL36
MMAATLCGSPMYMAP

ULK1

176

O75385
PQCSFMGMVISHDML

UBR5

2171

O95071