Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hexosyltransferase activity	POMT2 B3GNT9 OGT GALNT2 GALNT17 PYGM WDFY3 FUT8 CHPF B4GALT3	2.72e-05	211	184	10	GO:0016758
GeneOntologyMolecularFunction	glycosyltransferase activity	POMT2 B3GNT9 GLT8D1 OGT GALNT2 GALNT17 PYGM WDFY3 FUT8 CHPF B4GALT3	7.74e-05	288	184	11	GO:0016757
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2D KMT2A SMYD3	8.81e-05	10	184	3	GO:0140999
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	B3GNT9 GLT8D1 OGT GALNT2 GALNT17 WDFY3 CHPF B4GALT3	8.86e-05	153	184	8	GO:0008194
GeneOntologyMolecularFunction	histone modifying activity	NSD1 RIOX1 CREBBP KMT2D KMT2A TADA2A PRKDC SMYD3 KDM4B	2.83e-04	229	184	9	GO:0140993
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	NSD1 METTL13 KMT2D KMT2A SMYD3	4.10e-04	68	184	5	GO:0016279
GeneOntologyMolecularFunction	N-methyltransferase activity	NSD1 TRMT1 METTL13 KMT2D KMT2A SMYD3	4.27e-04	105	184	6	GO:0008170
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	NSD1 METTL13 KMT2D KMT2A SMYD3	4.39e-04	69	184	5	GO:0016278
GeneOntologyMolecularFunction	histone H3K36 dimethyltransferase activity	NSD1 SMYD3	5.01e-04	4	184	2	GO:0140954
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	NSD1 KMT2D KMT2A SMYD3	7.10e-04	44	184	4	GO:0140938
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2D KMT2A SMYD3	7.82e-04	20	184	3	GO:0042800
GeneOntologyMolecularFunction	methyltransferase activity	METTL3 NSD1 TRMT1 BHMT METTL13 KMT2D KMT2A SMYD3	8.27e-04	213	184	8	GO:0008168
GeneOntologyMolecularFunction	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	WDFY3 B4GALT3	8.29e-04	5	184	2	GO:0003831
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	METTL3 NSD1 TRMT1 METTL13 KMT2D KMT2A SMYD3	1.10e-03	172	184	7	GO:0008757
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	METTL3 NSD1 TRMT1 BHMT METTL13 KMT2D KMT2A SMYD3	1.14e-03	224	184	8	GO:0016741
GeneOntologyCellularComponent	spectrin	SPTA1 SPTB SPTBN4	5.69e-05	9	187	3	GO:0008091
Domain	ZnF_C2HC	FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	1.09e-06	55	184	7	SM00343
Domain	Znf_CCHC	FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	1.09e-06	55	184	7	IPR001878
Domain	Spectrin_repeat	KALRN SPTA1 SPTB PPL SPTBN4	8.61e-06	29	184	5	IPR002017
Domain	SPEC	KALRN SPTA1 SPTB PPL SPTBN4	1.43e-05	32	184	5	SM00150
Domain	Spectrin/alpha-actinin	KALRN SPTA1 SPTB PPL SPTBN4	1.43e-05	32	184	5	IPR018159
Domain	Spectrin	KALRN SPTA1 SPTB SPTBN4	6.97e-05	23	184	4	PF00435
Domain	Period_circadian-like_C	PER1 PER2	2.88e-04	3	184	2	IPR022728
Domain	Period_C	PER1 PER2	2.88e-04	3	184	2	PF12114
Domain	DUF3523	ATAD3B ATAD3C	2.88e-04	3	184	2	IPR021911
Domain	DUF3523	ATAD3B ATAD3C	2.88e-04	3	184	2	PF12037
Domain	CPSF_A	SF3B3 CPSF1	2.88e-04	3	184	2	PF03178
Domain	Cleavage/polyA-sp_fac_asu_C	SF3B3 CPSF1	2.88e-04	3	184	2	IPR004871
Domain	Post-SET_dom	NSD1 KMT2D KMT2A	4.79e-04	16	184	3	IPR003616
Domain	PostSET	NSD1 KMT2D KMT2A	4.79e-04	16	184	3	SM00508
Domain	POST_SET	NSD1 KMT2D KMT2A	4.79e-04	16	184	3	PS50868
Domain	TPR-like_helical_dom	NRDE2 SH3TC2 OGT LONRF1 RGPD1 TRAPPC8 FICD PRKDC ANAPC7	5.19e-04	233	184	9	IPR011990
Domain	Spectrin_bsu	SPTB SPTBN4	5.72e-04	4	184	2	IPR016343
Domain	SET	NSD1 KMT2D KMT2A SMYD3	6.94e-04	41	184	4	PF00856
Domain	TPR-contain_dom	SH3TC2 OGT LONRF1 RGPD1 FICD PRKDC ANAPC7	7.24e-04	150	184	7	IPR013026
Domain	Cadherin_CS	PCDHGA5 PCDHA6 PCDHA4 DCHS1 PCDH10 CDH3	7.37e-04	109	184	6	IPR020894
Domain	PHD	NSD1 KMT2D KMT2A PHF21B KDM4B	8.69e-04	75	184	5	PF00628
Domain	CADHERIN_1	PCDHGA5 PCDHA6 PCDHA4 DCHS1 PCDH10 CDH3	8.91e-04	113	184	6	PS00232
Domain	Cadherin	PCDHGA5 PCDHA6 PCDHA4 DCHS1 PCDH10 CDH3	8.91e-04	113	184	6	PF00028
Domain	CADHERIN_2	PCDHGA5 PCDHA6 PCDHA4 DCHS1 PCDH10 CDH3	9.32e-04	114	184	6	PS50268
Domain	-	PCDHGA5 PCDHA6 PCDHA4 DCHS1 PCDH10 CDH3	9.32e-04	114	184	6	2.60.40.60
Domain	FYrich_C	KMT2D KMT2A	9.47e-04	5	184	2	IPR003889
Domain	FYrich_N	KMT2D KMT2A	9.47e-04	5	184	2	IPR003888
Domain	FYRC	KMT2D KMT2A	9.47e-04	5	184	2	SM00542
Domain	FYRN	KMT2D KMT2A	9.47e-04	5	184	2	SM00541
Domain	FYRN	KMT2D KMT2A	9.47e-04	5	184	2	PF05964
Domain	FYRC	KMT2D KMT2A	9.47e-04	5	184	2	PF05965
Domain	FYRC	KMT2D KMT2A	9.47e-04	5	184	2	PS51543
Domain	FYRN	KMT2D KMT2A	9.47e-04	5	184	2	PS51542
Domain	CA	PCDHGA5 PCDHA6 PCDHA4 DCHS1 PCDH10 CDH3	9.76e-04	115	184	6	SM00112
Domain	Cadherin-like	PCDHGA5 PCDHA6 PCDHA4 DCHS1 PCDH10 CDH3	1.02e-03	116	184	6	IPR015919
Domain	-	NRDE2 SH3TC2 OGT LONRF1 RGPD1 TRAPPC8 FICD ANAPC7	1.05e-03	207	184	8	1.25.40.10
Domain	SET	NSD1 KMT2D KMT2A SMYD3	1.08e-03	46	184	4	SM00317
Domain	Cadherin	PCDHGA5 PCDHA6 PCDHA4 DCHS1 PCDH10 CDH3	1.12e-03	118	184	6	IPR002126
Domain	EPHD	KMT2D KMT2A KDM4B	1.26e-03	22	184	3	PS51805
Domain	TPR_REGION	SH3TC2 OGT LONRF1 RGPD1 FICD PRKDC ANAPC7	1.26e-03	165	184	7	PS50293
Domain	TPR	SH3TC2 OGT LONRF1 RGPD1 FICD PRKDC ANAPC7	1.26e-03	165	184	7	PS50005
Domain	SET_dom	NSD1 KMT2D KMT2A SMYD3	1.47e-03	50	184	4	IPR001214
Domain	SET	NSD1 KMT2D KMT2A SMYD3	1.47e-03	50	184	4	PS50280
Domain	PHD	NSD1 KMT2D KMT2A PHF21B KDM4B	1.87e-03	89	184	5	SM00249
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A14 FAM90A1 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	2.59e-21	25	191	12	17684299
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A16 FAM90A10	2.12e-17	23	191	10	18602769
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOC2A HSPG2 RIN3 KALRN BCAS3 LONRF1 SHC1 FBXL12 PER1 NSD1 TRMT1 RABL6 TNRC18 KMT2D ARAP3 PER2 EPOP ZNRF3 PI4KA ZNF408 RRP12 CPSF1 SAC3D1 AKAP13 PRKDC NUP188 WDFY3 CHPF SUFU IQGAP3 RASAL1 ARHGAP33	1.42e-14	1105	191	32	35748872
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A14 VASN FAM90A1 RFLNB FAM90A17 FAM90A19 FAM90A22 FAM90A26 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A10	8.13e-12	164	191	13	22967998
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	RPL21 RAD51C DNAJB11 OGT RNGTT MYO1C AUP1 POLD1 RGPD1 FBXL12 PSMC1 TRMT1 NEK9 ATAD3B METTL13 SF3B3 QPCT CPSF1 TMPO PRKDC NUP188 SNRPA COPS6 SNRPB2 ANAPC7 SRSF9 SNRNP200 IQGAP3 CDK4	6.84e-11	1257	191	29	37317656
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	RPL21 DNAJB11 OGT RNGTT AUP1 POLD1 PPFIA1 SHC1 FBXL12 OBSL1 PSMC1 PPL IGF2BP2 ARAP3 PTPRM VPS35 OS9 PRKDC NUP188 PYCR2 FUT8 SUFU SNRNP200 VCPIP1	9.66e-10	974	191	24	28675297
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	OGT COPZ1 RGPD1 PER1 NEK9 PPL ITPR1 FBXO38 PACS1 TTBK2 ATAD3B SF3B3 PER2 MICALL2 RRP12 TMPO PYGM PRKDC NUP188 COPS6 SNRPB2 ANAPC7 SNRNP200 CCDC9 IQGAP3	5.74e-09	1155	191	25	20360068
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	RPL21 NRDE2 DNAJB11 TBRG4 OGT MYO1C AUP1 POLD1 TNPO2 PSMC1 NEK9 TTBK2 ATAD3B METTL13 IGF2BP2 SF3B3 RRP12 VPS35 PYGM AKAP13 NUP188 SNRPA SNRPB2 SNRNP200 SMYD3 CDK4	1.08e-08	1284	191	26	17353931
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SHANK1 OGT GALNT2 KALRN LONRF1 TNPO2 SPTB TSPYL2 OBSL1 PSMC1 CREBBP STAB1 MICU1 SPTBN4 DGLUCY GDAP1L1 RNF216 PRKDC WDFY3 FUT8 CHPF SNRNP200 SMYD3 DOP1B VCPIP1 B4GALT3	1.10e-08	1285	191	26	35914814
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RPL21 DNAJB11 ERCC6 MYO1C AUP1 POLD1 RTF2 PSMC1 CREBBP NEK9 METTL13 IGF2BP2 SF3B3 OXCT1 ARAP3 PI4KA RRP12 VPS35 CPSF1 AKAP13 PRKDC WDFY3 PYCR2 SNRPA SRSF9 SNRNP200	3.08e-08	1353	191	26	29467282
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TBRG4 GLT8D1 GALNT2 AUP1 OBSL1 PSMC1 ATAD3B ZNRF3 PI4KA RRP12 VPS35 TMPO LSS PRKDC NUP188 FUT8 CHPF IQGAP3 VTI1B CDK4 VCPIP1	6.37e-08	942	191	21	31073040
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RPL21 TBRG4 MYO1C AUP1 POLD1 VPS13C PSMC1 NEK9 METTL13 SF3B3 MAPK15 PI4KA RRP12 VPS35 CPSF1 TMPO PRKDC NUP188 PYCR2 SNRPA SNRPB2 ANAPC7 SRSF9 SNRNP200 IQGAP3 CDK4	8.55e-08	1425	191	26	30948266
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	DNAJB11 TBRG4 GALNT2 MYO1C AUP1 POLD1 TNPO2 PSMC1 ITPR1 ATAD3B IGF2BP2 SF3B3 OXCT1 RFLNB RRP12 VPS35 TMPO KMT2A OS9 PRKDC NUP188 PYCR2 SRSF9 SNRNP200 VTI1B CDK4	1.05e-07	1440	191	26	30833792
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	METTL3 POLD1 PPFIA1 SHC1 PSMC1 STAB1 METTL13 SF3B3 CPSF1 TMPO PRKDC SNRPA COPS6 SNRPB2 ANAPC7 SNRNP200	1.64e-07	582	191	16	20467437
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	OGT GALNT2 BCAS3 VPS13C RTF2 SPTB TSPYL2 ZMIZ1 YJEFN3 CREBBP NEK9 MICU1 SPTBN4 PACS1 ATAD3B TNRC18 EEPD1 SEMA3B RASGEF1C OS9 AKAP13 LSS XYLB VGLL4 SMYD3 KDM4B	2.00e-07	1489	191	26	28611215
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DNAJB11 OGT ERCC6 MYO1C POLD1 PPFIA1 TSPYL2 PER1 OBSL1 CREBBP ATAD3B METTL13 IGF2BP2 SF3B3 ZNRF3 XYLB TADA2A NUP188 WDFY3 ANAPC7 SRSF9 ARHGAP33	2.52e-07	1116	191	22	31753913
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	DNAJB11 OGT MYO1C COPZ1 AUP1 POLD1 FBXL12 OBSL1 METTL13 PI4KA RRP12 VPS35 CPSF1 TMPO IQGAP3 CDK4	2.81e-07	606	191	16	36538041
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	RPL21 COPZ1 AUP1 POLD1 RTF2 PSMC1 TRMT1 METTL13 IGF2BP2 OXCT1 PRKDC NUP188 PYCR2 SNRNP200 IQGAP3 CDK4 VCPIP1	4.10e-07	704	191	17	29955894
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RPL21 SHANK1 OGT MYO1C KALRN BCAS3 SPTA1 PPFIA1 SPTB PSMC1 YJEFN3 SPTBN4 PACS1 ATAD3B SF3B3 ATAD3C NRXN2 PI4KA VPS35 TMPO KMT2A PYCR2 SNRNP200 RASAL1	1.25e-06	1431	191	24	37142655
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MYO1C PPL PAPOLG FBXO38 PACS1 KMT2D RRP12 CPSF1 TMPO KMT2A SAC3D1 PRKDC SRSF9 SNRNP200 CCDC9 KDM4B VCPIP1	1.50e-06	774	191	17	15302935
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	DNAJB11 RNGTT MYO1C PPFIA1 SHC1 FBXL12 PSMC1 ITPR1 FBXO38 PACS1 IGF2BP2 KMT2D MTMR11 PTPRM PI4KA RRP12 CPSF1 TMPO PYCR2 SUFU	1.53e-06	1049	191	20	27880917
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	RAD51C POMT2 HSPG2 DNAJB11 TBRG4 GALNT2 MYO1C COPZ1 VASN YJEFN3 ITPR1 DGLUCY ATAD3B IGF2BP2 SF3B3 ATAD3C VPS35 CPSF1 LSS PYCR2 FUT8 SNRPB2 SNRNP200 VCPIP1	1.59e-06	1451	191	24	30550785
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	DNAJB11 BCAS3 POLD1 PSMC1 NEK9 ATAD3B IGF2BP2 OXCT1 VPS35 CPSF1 TMPO PRKDC NUP188 PYCR2	1.73e-06	534	191	14	35032548
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYO1C ARAP3 PI4KA RRP12 TMPO AKAP13 PRKDC SNRNP200 IQGAP3	1.95e-06	202	191	9	33005030
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	ATAD3B SF3B3 ZNRF3 RRP12 CPSF1 KMT2A PRKDC SNRNP200 IQGAP3	1.95e-06	202	191	9	24639526
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TNPO2 NLRP1 FAM90A1 CREBBP TNRC18 KMT2D OXCT1 TMPO LSS PRKDC SUFU KDM4B	2.35e-06	398	191	12	35016035
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	RPL21 MYO1C POLD1 PSMC1 RIOX1 IGF2BP2 SF3B3 RRP12 PRKDC SNRNP200	2.94e-06	272	191	10	25315684
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	POMT2 HSPG2 DNAJB11 B3GNT9 GLT8D1 GALNT2 VASN PSMC1 PODXL2 NEK9 BTN2A1 ITPR1 RRP12 VPS35 SEMA3B SLITRK5 CPSF1 TMPO FUT8 CHPF B4GALT3	3.21e-06	1201	191	21	35696571
Pubmed	Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex.	CREBBP TADA2A PRKDC	3.22e-06	6	191	3	9488450
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	RNGTT TNPO2 VPS13C PSMC1 ZNF831 PI4KA ZNF408 PITPNM3 CPSF1 TMPO AKAP13 PRKDC NUP188 PCDH10 SNRNP200 DOP1B	3.51e-06	736	191	16	29676528
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	DNAJB11 OGT AUP1 PSMC1 PI4KA RRP12 VPS35 OS9 PRKDC NUP188 COPS6 ANAPC7 CDK4 VCPIP1	3.76e-06	571	191	14	37167062
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	OBSL1 STAB1 METTL13 NRXN2 ZNRF3 WDFY3 SNRNP200 KDM4B DOP1B	4.70e-06	225	191	9	12168954
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	DNAJB11 RNGTT AUP1 PER1 TRAPPC8 CREBBP ITIH5 TMPO RNF216 TADA2A NUP188 PYCR2 ANAPC7 SRSF9 SNRNP200	5.04e-06	670	191	15	22990118
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RPL21 SHANK1 DNAJB11 KALRN BCAS3 RGPD1 PER1 PSMC1 ITPR1 MICU1 ATAD3B TNRC18 OXCT1 ATAD3C PI4KA SLITRK5 PITPNM3 PYCR2 RASAL1 VCPIP1	5.24e-06	1139	191	20	36417873
Pubmed	Functional proteomics mapping of a human signaling pathway.	HSPG2 ERCC6 AUP1 CREBBP PPL KMT2D MTMR11 VPS35 RNF216 OS9 PYCR2 SNRPA CHPF VCPIP1	5.56e-06	591	191	14	15231748
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	EFCAB5 PPFIA1 NSD1 FBXO38 KMT2D SF3B3 VPS35 TMPO SNRNP200	6.46e-06	234	191	9	36243803
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	RNGTT MYO1C COPZ1 AUP1 VPS13C PPFIA1 CNTRL PODXL2 PPL RABL6 PI4KA SLITRK5 TMPO PRKDC PCDH10 SNRNP200	6.93e-06	777	191	16	35844135
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	RPL21 RAD51C RNGTT COPZ1 PPFIA1 PSMC1 ATAD3B IGF2BP2 SF3B3 QPCT CPSF1 TMPO SNRPA PCDH10 ANAPC7 SRSF9 SNRNP200 IQGAP3	7.68e-06	971	191	18	33306668
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RPL21 OGT AUP1 SPTA1 NSD1 KMT2D SF3B3 EPOP RRP12 CPSF1 TMPO KMT2A TADA2A PRKDC NUP188 SNRPA SNRPB2 ANAPC7 SRSF9 SNRNP200 VCPIP1	9.99e-06	1294	191	21	30804502
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTA1 SPTB SHC1 SPTBN4	1.02e-05	25	191	4	8493579
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	RPL21 COPZ1 POLD1 PSMC1 NEK9 SF3B3 VPS35 TMPO PRKDC NUP188 PYCR2 SNRPA SRSF9 SNRNP200	1.31e-05	638	191	14	33239621
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RPL21 DNAJB11 GALNT2 OBSL1 PSMC1 IGF2BP2 SF3B3 PI4KA RRP12 CPSF1 TMPO PRKDC NUP188 SNRPA SNRPB2 ANAPC7 SRSF9 SNRNP200	1.57e-05	1024	191	18	24711643
Pubmed	New nomenclature for chromatin-modifying enzymes.	NSD1 CREBBP KMT2D KMT2A KDM4B	1.57e-05	57	191	5	18022353
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	MYO1C POLD1 VPS13C PSMC1 NEK9 METTL13 KMT2D NUP188 SNRNP200	1.69e-05	264	191	9	32814769
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	AUP1 RTF2 TRMT1 NEK9 RABL6 SF3B3 VPS35 CPSF1 PRKDC PYCR2 SNRPA COPS6 SRSF9 CCDC9	1.70e-05	653	191	14	33742100
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	RPL21 OGT AUP1 PSMC1 ATAD3B SF3B3 TRAT1 PI4KA PRKDC NUP188 SNRNP200	1.77e-05	408	191	11	33766124
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SH3TC2 PER1 TRAPPC8 NEK9 ATAD3B METTL13 TNRC18 ATAD3C EEPD1 SLITRK5 SNRNP200 PDZRN4	2.02e-05	493	191	12	15368895
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	RPL21 DNAJB11 OGT COPZ1 POLD1 TNPO2 PSMC1 NEK9 IGF2BP2 SF3B3 RRP12 VPS35 TMPO PRKDC PYCR2 COPS6 ANAPC7 SNRNP200 IQGAP3	2.10e-05	1149	191	19	35446349
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ERCC6 POLD1 PPFIA1 RABL6 ZNF408 RRP12 VPS35 CPSF1 TMPO KMT2A COPS6 KDM4B	2.19e-05	497	191	12	36774506
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TBRG4 NLRP1 TRAPPC8 NRXN2 WDFY3 DOP1B	2.20e-05	102	191	6	10231032
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	RNGTT POLD1 NEK9 IGF2BP2 TMPO PRKDC SNRNP200 IQGAP3	2.36e-05	211	191	8	17314511
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	KALRN SPTB SPTBN4	2.60e-05	11	191	3	17607528
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	TBRG4 MYO1C AUP1 VPS13C SHC1 OBSL1 PSMC1 TRMT1 ITPR1 MICU1 ATAD3B IGF2BP2 OXCT1 PI4KA RRP12 CPSF1 TMPO NUP188 PYCR2 ANAPC7 SRSF9 VCPIP1	2.75e-05	1496	191	22	32877691
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	RPL21 SHANK1 COL6A3 ERCC6 NLRP1 SF3B3 QPCT CPSF1 TMPO PRKDC LRRC37B SNRNP200	2.98e-05	513	191	12	25798074
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	PER1 OBSL1 CREBBP IGF2BP2 MAPK15 ATAD3C VPS35 KMT2A PRKDC WDFY3 CDK4	2.99e-05	432	191	11	23455922
Pubmed	Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart.	PER1 PER2	3.00e-05	2	191	2	23977055
Pubmed	Masking responses to light in period mutant mice.	PER1 PER2	3.00e-05	2	191	2	21793695
Pubmed	Alterations in the expression of Per1 and Per2 induced by Aβ31-35 in the suprachiasmatic nucleus, hippocampus, and heart of C57BL/6 mouse.	PER1 PER2	3.00e-05	2	191	2	27021954
Pubmed	A deletional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin Tokyo (beta 220/216).	SPTA1 SPTB	3.00e-05	2	191	2	1391962
Pubmed	Constant darkness is a circadian metabolic signal in mammals.	PER1 PER2	3.00e-05	2	191	2	16421573
Pubmed	Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.	PER1 PER2	3.00e-05	2	191	2	11389837
Pubmed	Circadian regulation of central ethanol sensitivity by the mPer2 gene.	PER1 PER2	3.00e-05	2	191	2	19523042
Pubmed	Differential daily expression of Per1 and Per2 mRNA in the suprachiasmatic nucleus of fetal and early postnatal mice.	PER1 PER2	3.00e-05	2	191	2	11207804
Pubmed	Resetting the brain clock: time course and localization of mPER1 and mPER2 protein expression in suprachiasmatic nuclei during phase shifts.	PER1 PER2	3.00e-05	2	191	2	15009158
Pubmed	Insights into structure and activity relationship of clinically mutated PER1 and PER2 class A β-lactamase enzymes.	PER1 PER2	3.00e-05	2	191	2	35475497
Pubmed	Time-dependent inhibitory effect of lipopolysaccharide injection on Per1 and Per2 gene expression in the mouse heart and liver.	PER1 PER2	3.00e-05	2	191	2	20370466
Pubmed	cAMP-dependent signaling as a core component of the mammalian circadian pacemaker.	PER1 PER2	3.00e-05	2	191	2	18487196
Pubmed	Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction.	PER1 PER2	3.00e-05	2	191	2	35810166
Pubmed	Cardiac atrial circadian rhythms in PERIOD2::LUCIFERASE and per1:luc mice: amplitude and phase responses to glucocorticoid signaling and medium treatment.	PER1 PER2	3.00e-05	2	191	2	23110090
Pubmed	Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1.	PER1 PER2	3.00e-05	2	191	2	33053337
Pubmed	Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain.	CREBBP KMT2A	3.00e-05	2	191	2	12205094
Pubmed	Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice.	PER1 PER2	3.00e-05	2	191	2	24603368
Pubmed	Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin.	SPTA1 SPTB	3.00e-05	2	191	2	15492010
Pubmed	Period gene expression in mouse endocrine tissues.	PER1 PER2	3.00e-05	2	191	2	12775559
Pubmed	Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1.	SPTA1 SPTB	3.00e-05	2	191	2	8102379
Pubmed	Forebrain oscillators ticking with different clock hands.	PER1 PER2	3.00e-05	2	191	2	17996461
Pubmed	Circadian gene expression is resilient to large fluctuations in overall transcription rates.	PER1 PER2	3.00e-05	2	191	2	19078963
Pubmed	The circadian clock and tumor suppression by mammalian period genes.	PER1 PER2	3.00e-05	2	191	2	15817328
Pubmed	Beta-spectrin Promiss-ao: a translation initiation codon mutation of the beta-spectrin gene (ATG --> GTG) associated with hereditary spherocytosis and spectrin deficiency in a Brazilian family.	SPTA1 SPTB	3.00e-05	2	191	2	9414314
Pubmed	Low reproductive success in Per1 and Per2 mutant mouse females due to accelerated ageing?	PER1 PER2	3.00e-05	2	191	2	18367514
Pubmed	Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.	SPTA1 SPTB	3.00e-05	2	191	2	9005995
Pubmed	Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain.	PER1 PER2	3.00e-05	2	191	2	19477955
Pubmed	Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis.	SPTA1 SPTB	3.00e-05	2	191	2	7104494
Pubmed	A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis.	SPTA1 SPTB	3.00e-05	2	191	2	6215583
Pubmed	Mice lacking Period 1 and Period 2 circadian clock genes exhibit blue cone photoreceptor defects.	PER1 PER2	3.00e-05	2	191	2	23351077
Pubmed	Core circadian clock genes Per1 and Per2 regulate the rhythm in photoreceptor outer segment phagocytosis.	PER1 PER2	3.00e-05	2	191	2	34160105
Pubmed	Robust circadian rhythmicity of Per1 and Per2 mutant mice in constant light, and dynamics of Per1 and Per2 gene expression under long and short photoperiods.	PER1 PER2	3.00e-05	2	191	2	12054191
Pubmed	Inhibition of light- or glutamate-induced mPer1 expression represses the phase shifts into the mouse circadian locomotor and suprachiasmatic firing rhythms.	PER1 PER2	3.00e-05	2	191	2	9920673
Pubmed	mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning.	PER1 PER2	3.00e-05	2	191	2	15959842
Pubmed	Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis.	SPTA1 SPTB	3.00e-05	2	191	2	3580577
Pubmed	Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.	SPTA1 SPTB	3.00e-05	2	191	2	7883966
Pubmed	Influence of photoperiod duration and light-dark transitions on entrainment of Per1 and Per2 gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus.	PER1 PER2	3.00e-05	2	191	2	19840112
Pubmed	Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency†.	PER1 PER2	3.00e-05	2	191	2	30452546
Pubmed	Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.	KMT2D KMT2A	3.00e-05	2	191	2	26711341
Pubmed	Differential effects of two period genes on the physiology and proteomic profiles of mouse anterior tibialis muscles.	PER1 PER2	3.00e-05	2	191	2	17202855
Pubmed	Light-induced phase shifts in mice lacking mPER1 or mPER2.	PER1 PER2	3.00e-05	2	191	2	12693867
Pubmed	Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior.	PER1 PER2	3.00e-05	2	191	2	23039899
Pubmed	Spectrin Cosenza: a novel beta chain variant associated with Sp alphaI/74 hereditary elliptocytosis.	SPTA1 SPTB	3.00e-05	2	191	2	9163587
Pubmed	Light responsiveness of clock genes, Per1 and Per2, in the olfactory bulb of mice.	PER1 PER2	3.00e-05	2	191	2	21624349
Pubmed	Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality.	PER1 PER2	3.00e-05	2	191	2	31260634
Interaction	TOP3B interactions	DOC2A HSPG2 RIN3 MYO1C KALRN BCAS3 LONRF1 SPTB SHC1 FBXL12 PER1 NSD1 TRMT1 RABL6 IGF2BP2 TNRC18 KMT2D ARAP3 PER2 EPOP ZNRF3 PI4KA ZNF408 RRP12 CPSF1 SAC3D1 AKAP13 PRKDC NUP188 WDFY3 SNRPA CHPF SUFU SRSF9 IQGAP3 RASAL1 ARHGAP33	5.33e-09	1470	178	37	int:TOP3B
Interaction	C9orf72 interactions	RPL21 RAD51C DNAJB11 OGT RNGTT MYO1C AUP1 POLD1 RGPD1 FBXL12 PSMC1 TRMT1 FAM90A1 NEK9 ATAD3B METTL13 SF3B3 QPCT CPSF1 TMPO PRKDC NUP188 SNRPA COPS6 SNRPB2 ANAPC7 SRSF9 SNRNP200 IQGAP3 CDK4 EPHA8	5.18e-07	1319	178	31	int:C9orf72
Cytoband	8p23.1	FAM90A14 LONRF1 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	2.71e-12	154	191	12	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	FAM90A14 LONRF1 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	3.59e-10	234	191	12	chr8p23
Cytoband	14q32.11	NRDE2 PSMC1 DGLUCY	4.62e-05	17	191	3	14q32.11
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTB SPTBN4	8.61e-06	7	115	3	1113
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	NSD1 KMT2D KMT2A SMYD3	6.22e-05	34	115	4	487
GeneFamily	PHD finger proteins	NSD1 FANCL KMT2D KMT2A PHF21B	2.73e-04	90	115	5	88
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	SIGLEC12 HSPG2 KALRN OBSL1 PTPRM SIGLEC6	5.75e-04	161	115	6	593
GeneFamily	Immunoglobulin like domain containing	A1BG HSPG2 OBSL1 IL18R1 PTPRM SEMA3B	1.47e-03	193	115	6	594
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SIGLEC12 BTN2A1 BTN1A1	2.09e-03	40	115	3	592
GeneFamily	Sterile alpha motif domain containing	SHANK1 PPFIA1 ARAP3 EPHA8	2.40e-03	88	115	4	760
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POMT2 SH3TC2 PACS1 METTL13 MTMR11 PTPRM DCHS1 CPSF1	3.94e-07	165	181	8	62457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCell	droplet-Limb_Muscle-MUSCLE-1m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 COL6A3 PER1 PODXL2 IGF2BP2 PER2 SEMA3B CHPF	1.39e-06	195	181	8	fee9d13f48149cd5f921cfe4b8b3053cf6a6dbd2
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAB21L4 SPTB PPL BHMT GDAP1L1 QPCT EPHA8	8.18e-06	177	181	7	c80893e5cf5688ee9f5afc8f11b3890f296c9e1f
ToppCell	RA-16._Neuronal\|RA / Chamber and Cluster_Paper	ITIH5 ATAD3C MICALL2 SEMA3B RASGEF1C SLITRK5 HS3ST2	9.13e-06	180	181	7	5842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	VPS13C FANCL KMT2D XYLB PRKDC FUT8 DOP1B	1.09e-05	185	181	7	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	VPS13C NSD1 IL18R1 XYLB PRKDC FUT8 DOP1B	1.34e-05	191	181	7	9454f642c3621370fa23640b631301346b300950
ToppCell	Smart-seq2-thymus_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell\|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DNAJB11 COPZ1 AUP1 FICD QPCT CHPF CDK4	1.43e-05	193	181	7	bd82961502db42a0c862d3a29a2babe8032384c8
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	VPS13C CNTRL TSPYL2 TRAT1 KMT2A FAM118A FUT8	1.59e-05	196	181	7	c9fb81a0578db6d278b8582d7b3add6c407e6dcf
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 COL6A3 VASN PODXL2 IGF2BP2 SEMA3B CHPF	1.69e-05	198	181	7	b086af292a508a156266c2d899ba1caf820bf61c
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 COL6A3 B3GNT9 VASN PODXL2 SEMA3B CHPF	1.69e-05	198	181	7	1b90d632e59c3c47b936e829cceeb0334f05f34f
ToppCell	TCGA-Colorectal-Primary_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SF3B3 EPOP RRP12 SMOX CDH3 ANAPC7 IQGAP3	1.75e-05	199	181	7	c7d6a8398f2419b726a0461585d1ee0561654e3b
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_activated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOC2A A1BG EFCAB5 TBRG4 YJEFN3 SAC3D1 ARHGAP33	1.75e-05	199	181	7	6dc446a5d183b01bdf227e45bd88d0b3d8b1c56a
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SF3B3 EPOP RRP12 SMOX CDH3 ANAPC7 IQGAP3	1.75e-05	199	181	7	85b3b1ad01368dae4adbc9da7efc148e49992f69
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Macc1_Lrg1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	VASN ZNF831 CITED4 RFLNB EPOP RASGEF1C	2.54e-05	142	181	6	d08e1880425d285c4433014fe0242ac7ff7734af
Drug	Estropipate [7280-37-7]; Up 200; 9.2uM; MCF7; HT_HG-U133A	RIN3 OGT GALNT2 IQCC XYLB NUP188 SMOX ARHGAP33 KDM4B OSGIN1	3.65e-06	195	180	10	6808_UP
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	RNGTT SPTB PER1 PODXL2 PACS1 SLITRK5 TADA2A FAM118A KDM4B DOP1B	4.00e-06	197	180	10	3708_DN
Disease	germ cell cancer (implicated_via_orthology)	SNRPA SNRPB2	3.50e-05	2	175	2	DOID:2994 (implicated_via_orthology)
Disease	chronic obstructive pulmonary disease	EFCAB5 COL6A3 RIN3 BCAS3 PCDHGA5 IL18R1 BTN2A1 FBXO38 MTMR11 EPOP BTN1A1 RASGEF1C VGLL4 LRRC37B	6.66e-05	688	175	14	EFO_0000341
Disease	syndrome (implicated_via_orthology)	NSD1 ATAD3B ATAD3C	1.57e-04	18	175	3	DOID:225 (implicated_via_orthology)
Disease	Hereditary elliptocytosis	SPTA1 SPTB	2.08e-04	4	175	2	cv:C0013902
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTB SPTBN4	2.08e-04	4	175	2	DOID:0050882 (implicated_via_orthology)
Disease	neuromuscular disease (implicated_via_orthology)	ATAD3B ATAD3C	2.08e-04	4	175	2	DOID:440 (implicated_via_orthology)
Disease	depressive symptom measurement	GALNT2 PCDHA6 PCDHA4 BTN2A1 STAB1 KCNG2 BTN1A1 SEMA3B KMT2A TBC1D21	2.45e-04	426	175	10	EFO_0007006
Disease	Colorectal Carcinoma	SHANK1 ERCC6 KALRN POLD1 PER1 ZMIZ1 HHIP GDAP1L1 ARAP3 DCHS1 SNRPB2 SNRNP200 PDZRN4	3.04e-04	702	175	13	C0009402
Disease	sexual dimorphism measurement	DOC2A GALNT2 RGPD1 NSD1 ZMIZ1 BTN2A1 PACS1 HHIP IGF2BP2 CITED4 MTMR11 NYNRIN BTN1A1 SMOX SUFU TBC1D21 SRSF9	3.31e-04	1106	175	17	EFO_0021796
Disease	Weaver syndrome	NSD1 KMT2A	3.46e-04	5	175	2	C0265210
Disease	hereditary spherocytosis (is_implicated_in)	SPTA1 SPTB	3.46e-04	5	175	2	DOID:12971 (is_implicated_in)
Disease	Hereditary spherocytosis	SPTA1 SPTB	3.46e-04	5	175	2	cv:C0037889
Disease	Anemia, hereditary spherocytic hemolytic	SPTA1 SPTB	3.46e-04	5	175	2	C0221409
Disease	connective tissue disease (is_implicated_in)	SNRPA SNRPB2	3.46e-04	5	175	2	DOID:65 (is_implicated_in)
Disease	FEV/FEC ratio	EFCAB5 HSPG2 COL6A3 BCAS3 PCDHGA5 VPS13C NSD1 IL18R1 ITPR1 HHIP IGF2BP2 MTMR11 PTPRM RASGEF1C VGLL4 LRRC37B SUFU PCDH10	3.89e-04	1228	175	18	EFO_0004713
Disease	lymphocyte count	SH3TC2 KALRN BCAS3 PCDHGA5 SPTA1 PPFIA1 SPTB NSD1 PCDHA6 ZMIZ1 ZNF831 ITPR1 IGF2BP2 NRXN2 TRAT1 ZNRF3 QPCT TADA2A SMOX KDM4B	4.52e-04	1464	175	20	EFO_0004587
Disease	Acute monocytic leukemia	RAD51C FANCL KMT2A	4.82e-04	26	175	3	C0023465
Disease	myeloperoxidase measurement	RAD51C GALNT2 BCAS3	4.82e-04	26	175	3	EFO_0005243
Disease	body surface area	CALCR RGPD1 PER1 NSD1 ZMIZ1 HHIP IGF2BP2 MTMR11 MICALL2 AKAP13 VGLL4 TBC1D21	4.84e-04	643	175	12	EFO_0022196
Disease	Elliptocytosis, Hereditary	SPTA1 SPTB	5.16e-04	6	175	2	C0013902
Disease	Hypotrichosis simplex	RPL21 LSS	7.20e-04	7	175	2	C1854310
Disease	monocyte count	RIN3 RNGTT MYO1C KALRN BCAS3 SPTA1 ZMIZ1 IGF2BP2 CITED4 GSDMD PI4KA ZNF408 RRP12 RNF216 AKAP13 TADA2A PRKDC KDM4B	8.98e-04	1320	175	18	EFO_0005091
Disease	sialic acid-binding Ig-like lectin 6 measurement	SIGLEC12 SIGLEC6	9.57e-04	8	175	2	EFO_0008285
Disease	acetoacetate measurement	GALNT2 OXCT1	9.57e-04	8	175	2	EFO_0010111
Disease	Hereditary spherocytosis	SPTA1 SPTB	9.57e-04	8	175	2	C0037889
Disease	sialic acid-binding Ig-like lectin 12 measurement	SIGLEC12 KALRN	9.57e-04	8	175	2	EFO_0802066
Disease	neutrophil percentage of leukocytes	RIN3 KALRN SPTA1 TRMT1 ZMIZ1 ZNF831 IL18R1 ZNRF3 AKAP13 PRKDC KDM4B	1.09e-03	610	175	11	EFO_0007990
Disease	obsolete_red blood cell distribution width	OGT GALNT2 COPZ1 KALRN BCAS3 PCDHGA5 SPTA1 SPTB RGPD1 TRMT1 MICU1 IGF2BP2 ZNRF3 EEPD1 AKAP13 SMOX LRRC37B CDH3	1.13e-03	1347	175	18	EFO_0005192
Disease	vital capacity	HSPG2 COL6A3 SH3TC2 RIN3 MYO1C MAB21L4 PER1 PCDHA6 PCDHA4 ZMIZ1 ITPR1 HHIP IGF2BP2 MTMR11 XYLB SMOX KDM4B	1.14e-03	1236	175	17	EFO_0004312
Disease	Intellectual Disability	NSD1 TRMT1 ZMIZ1 RABL6 PACS1 NRXN2 LSS PYCR2 FUT8	1.46e-03	447	175	9	C3714756
Disease	Bladder Neoplasm	YJEFN3 CREBBP KMT2D MAPK15 KMT2A	1.52e-03	140	175	5	C0005695
Disease	Malignant neoplasm of urinary bladder	YJEFN3 CREBBP KMT2D MAPK15 KMT2A	1.56e-03	141	175	5	C0005684
Disease	pulse pressure measurement	COL6A3 RIN3 GLT8D1 MYO1C VASN CNTRL PCDHA6 PCDHA4 ZNF831 NEK9 SPTBN4 FBXO38 EEPD1 PITPNM3 AKAP13 FAM118A SUFU KDM4B	1.62e-03	1392	175	18	EFO_0005763
Disease	Microphthalmos	ERCC6 KMT2D	1.86e-03	11	175	2	C0026010
Disease	total hip arthroplasty, osteoarthritis	HHIP VGLL4 SMOX	1.99e-03	42	175	3	EFO_0009806, MONDO_0005178
Disease	lean body mass	DOC2A CALCR VPS13C NSD1 HHIP IGF2BP2 AKAP13 VGLL4	1.99e-03	379	175	8	EFO_0004995
Disease	acute myeloid leukemia (implicated_via_orthology)	CREBBP KMT2A	2.22e-03	12	175	2	DOID:9119 (implicated_via_orthology)
Disease	age of onset of multiple sclerosis	ITPR1 PER2	2.22e-03	12	175	2	OBA_2001029
Disease	immunoglobulin isotype switching measurement	RIN3 PAPOLG ZNRF3	2.27e-03	44	175	3	EFO_0010128
Disease	urate measurement	BCAS3 NSD1 ZMIZ1 STAB1 IGF2BP2 ANKRD33 MICALL2 NRXN2 PYGM AKAP13 FUT8 KDM4B PDZRN4	2.74e-03	895	175	13	EFO_0004531
Disease	chronic kidney disease	COL6A3 RIN3 BCAS3 MICALL2 PTPRM TBC1D21	2.87e-03	235	175	6	EFO_0003884
Disease	PR interval	EFCAB5 HSPG2 KALRN PPFIA1 PCDHA4 ZMIZ1 IGF2BP2 THAP12 SMYD3	2.91e-03	495	175	9	EFO_0004462
Disease	Fanconi anemia	RAD51C FANCL	3.04e-03	14	175	2	cv:C0015625
Disease	serum gamma-glutamyl transferase measurement	UPB1 KALRN NLRP1 RWDD2B ZMIZ1 BHMT ITPR1 STAB1 MICU1 PTPRM KMT2A AKAP13 SRSF9	3.27e-03	914	175	13	EFO_0004532
Disease	sitting height ratio	NSD1 ZMIZ1 PTPRM	3.47e-03	51	175	3	EFO_0007118
Disease	Lymphoma, Follicular, Grade 2	CREBBP KMT2D	3.49e-03	15	175	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	CREBBP KMT2D	3.49e-03	15	175	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	CREBBP KMT2D	3.49e-03	15	175	2	C1956130
Disease	Lymphoma, Large-Cell, Follicular	CREBBP KMT2D	3.49e-03	15	175	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	CREBBP KMT2D	3.49e-03	15	175	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	CREBBP KMT2D	3.49e-03	15	175	2	C0079758
Disease	uric acid measurement	BCAS3 ZMIZ1 PACS1 IGF2BP2 ANKRD33 MICALL2 NRXN2 PYGM AKAP13 KDM4B	3.62e-03	610	175	10	EFO_0004761
Disease	Leukemia, Myelocytic, Acute	RAD51C NSD1 FANCL CREBBP KMT2A	3.79e-03	173	175	5	C0023467
Disease	Rolandic epilepsy	KALRN PTPRM	3.97e-03	16	175	2	Orphanet_1945
Disease	Small cell carcinoma of lung	CREBBP TTBK2 KMT2A	4.07e-03	54	175	3	C0149925
Disease	muscular dystrophy (is_implicated_in)	POMT2 COL6A3	4.49e-03	17	175	2	DOID:9884 (is_implicated_in)
Disease	Autistic Disorder	SHANK1 UPB1 PER1 NSD1 NRXN2 PCDH10	4.78e-03	261	175	6	C0004352
Disease	Endometrial Neoplasms	POLD1 TSPYL2 SEMA3B	4.98e-03	58	175	3	C0014170
Disease	androstenedione measurement, estrone measurement	GALNT2 PTPRM	5.03e-03	18	175	2	EFO_0007970, EFO_0007972
Disease	Bone marrow hypocellularity	RAD51C FANCL	5.03e-03	18	175	2	C1855710
Disease	breast cancer (is_marker_for)	BCAS3 KMT2D MAPK15 KDM4B CDK4	5.03e-03	185	175	5	DOID:1612 (is_marker_for)
Disease	platelet component distribution width	SH3TC2 RIN3 GALNT2 COPZ1 KALRN SPTA1 ZMIZ1 ZNF831 METTL13 NYNRIN AKAP13	5.59e-03	755	175	11	EFO_0007984
Disease	neck circumference	ANKRD33 GALNT17	5.60e-03	19	175	2	EFO_0011043
Disease	unipolar depression	RNGTT MAB21L4 PER1 PCDHA6 PCDHA4 BTN2A1 KCNG2 GALNT17 ARAP3 BTN1A1 DCHS1 XYLB HS3ST2 SNRNP200 PHF21B	5.62e-03	1206	175	15	EFO_0003761
Disease	C-reactive protein measurement	GALNT2 VPS13C ZMIZ1 IL18R1 PPL BHMT ITPR1 MICU1 PACS1 GSDMD NYNRIN EEPD1 SRSF9 ARHGAP33 OSGIN1	5.62e-03	1206	175	15	EFO_0004458
Disease	platelet-derived growth factor BB measurement	COPZ1 SMOX SUFU	5.74e-03	61	175	3	EFO_0008264

Protein segments in the cluster

Peptide	Gene	Start	Entry
HIRAIAEELAPERGF	BHMT	306	Q93088
CFIHREGLASREIPQ	FAM200B	326	P0CF97
GNEENPHRFDLLVRT	B4GALT3	296	O60512
LNHVVDGLVRPEEVA	CNTRL	796	Q7Z7A1
ARSVKLRPGEHFVED	ARAP3	961	Q8WWN8
EAGEVPFNHEILREA	COPS6	246	Q7L5N1
SPAVLVHRDGREQEA	BTN1A1	71	Q13410
HLVEVVPNGELVRRD	CALCR	201	P30988
QREPRLGELRVFDQH	HSD3B7	31	Q9H2F3
RVVQELDHGGEFIPV	GSDMD	11	P57764
NAEELRHPFSGEERV	AKAP13	1626	Q12802
LRRQNHPEAGEVFVR	CREBBP	1346	Q92793
EAQELFSVRHGPIRA	BCAS3	111	Q9H6U6
GEEDVRRLFQPFGHI	CELF6	146	Q96J87
IVDFRREHGPFRSVE	EEPD1	161	Q7L9B9
LKRRIQPAFGADHDV	ERCC6	1036	Q03468
HDGAQPLRVLFRRLE	FAM90A10	386	A6NDY2
VRLVIVDGIAFPFRH	RAD51C	236	O43502
AVERVDEGAFQLPHV	RASAL1	621	O95294
RDGEHKPFTIVLERE	PDZRN4	216	Q6ZMN7
FEGRHQFEELPVLRR	NSD1	386	Q96L73
IVHLEAFGDPVIVLR	ANKRD33	16	Q7Z3H0
HRLEGDTLIIPRVAQ	HSPG2	3256	P98160
GVIQDDHIPFLRRGV	QPCT	301	Q16769
GEHRVILPDDVRDFI	RABL6	181	Q3YEC7
PRVFLEHGEQACERD	IQCC	206	Q4KMZ1
RLVLPFARDADVGVN	PCDHGA5	151	Q9Y5G8
HDGAQPLRVLFRRLE	FAM90A7	386	A6NKC0
RLNLGEEVPVIIHRD	GDAP1L1	91	Q96MZ0
DRPLQVFHVDVEVRD	PCDHA6	111	Q9UN73
RREGDHEFLEVPEAQ	A1BG	151	P04217
QEAIIHFREAIRLAP	ANAPC7	356	Q9UJX3
LRFTRPLQDVEGREH	OBSL1	341	O75147
DFVVLENEGPHRRLV	OBSL1	851	O75147
DFILAGFRVRPELHI	OR9K2	36	Q8NGE7
DCEVFRQHRGPQLLA	PODXL2	401	Q9NZ53
HDGAQPLRVLFRRLE	FAM90A23	386	A8MXZ1
VLERVHALDPRFIVD	MAB21L4	46	Q08AI8
HVVARDPDLGEAARV	DCHS1	1566	Q96JQ0
GTRAVLEFIRVHPDV	HS3ST2	126	Q9Y278
LEFIRVHPDVRALGT	HS3ST2	131	Q9Y278
RPENGEEHTFAVEIL	IL18R1	386	Q13478
EQEELHYIPIRVLGR	NEK9	46	Q8TD19
ERFNERNPPELIGVH	RNGTT	111	O60942
ILHDLRPQDRFSIIG	ITIH5	321	Q86UX2
LRLEELGDQRHAPFR	ITPR1	536	Q14643
FIPEEILIHGRDFRL	MTMR11	126	A4FU01
PNRILDSEVRRAFGH	MTMR11	236	A4FU01
HDGAQPLRVLFRRLE	FAM90A1	386	Q86YD7
READVRPRAHEGVQL	MAPK15	316	Q8TD08
IRNVHFLPDGRSVVD	LONRF1	626	Q17RB8
VFVVGHINRDAPGRE	DOP1B	201	Q9Y3R5
LEIHRRVLGYVDPVE	FICD	291	Q9BVA6
HVLEAANEGDVRPFI	FICD	401	Q9BVA6
ELRVPDHQDIAFGAL	GALNT2	436	Q10471
VLPFRRESLAEEHEG	CPSF1	161	Q10570
HDGAQPLRVLFRRLE	FAM90A22	386	A8MWA6
FRVAEEHLGIPALLD	MICALL2	66	Q8IY33
EFERHDPVDGRITER	MICU1	311	Q9BPX6
HDGAQPLRVLFRRLE	FAM90A14	386	P0C7W9
PRFSEDQRRELGAVH	PER1	1171	O15534
RHKVRVGPLNEDVFA	PER2	431	O15055
FAPLVHLAERELGAR	KCNG2	336	Q9UJ96
LARLQEGRQPEHRDV	PPL	56	O60437
PDYVEENRGHLIEIR	NLRP1	301	Q9C000
ENRGHLIEIRDLFGP	NLRP1	306	Q9C000
FPVDVEGSRRLIDEH	KALRN	216	O60229
AVRHPDIEAQERGVR	LSS	661	P48449
VQRLDGREIHATIPE	NRDE2	1051	Q9H7Z3
PDLIADALHRIGQVE	NRXN2	1076	Q9P2S2
QVVHRVALRGEDVPL	COPZ1	141	P61923
PVDFHGIFQLDERRR	PI4KA	61	P42356
EARFLNVIERHPVDI	KDM4B	826	O94953
KHELLEEARRQGLPF	PPFIA1	861	Q13136
DRAAGHQADEILVPL	LRRC37B	161	Q96QE4
RHAVDGRQEEIPVVI	GLT8D1	56	Q68CQ7
RVETSEHFRIDGPVI	TMPO	261	P42167
PDENEEVIVRIIGHF	IGF2BP2	551	Q9Y6M1
HDGAQPLRVLFRRLE	FAM90A17	386	P0DV74
QRPYELVIEVRDHGQ	PCDH10	651	Q9P2E7
HDGAQPLRVLFRRLE	FAM90A16	386	P0DV73
HDGAQPLRVLFRRLE	FAM90A19	386	P0DV76
GVLVEIEDLPASHFR	IQGAP3	1546	Q86VI3
LDGIHLLDPDVVARF	METTL3	551	Q86U44
EVGFGLEHVSREQIR	PACS1	346	Q6VY07
AGEEHLPVLVRFVDE	THAP12	271	O43422
DRPLQVFHVDVEVRD	PCDHA4	111	Q9UN74
HDGAQPLRVLFRRLE	FAM90A8	386	A6NJQ4
RVPFLGGLIQHVVED	FBXO38	271	Q6PIJ6
GIRNLRAVEDAFVPV	PAPOLG	141	Q9BWT3
PGEEERLVRVHDVIQ	ARHGAP33	416	O14559
FGVLAVDTLRDPHEI	EFCAB5	1116	A4FU69
LEVLHPGDVAEFRRK	FAM118A	66	Q9NWS6
SHNEFIGEIRVPLRR	DOC2A	186	Q14183
EVALLRRLEAFEHPN	CDK4	56	P11802
APGDLRQEHFDRLIR	EPOP	236	A6NHQ4
AAEEQLRRPRIVHVG	UPB1	61	Q9UBR1
PDFERVRCGLEHERQ	CCDC9	226	Q9Y3X0
FDHPNIIRLEGVVTR	EPHA8	691	P29322
LRVNHFVPEAGSRLD	COL6A3	1726	P12111
GDAFHEIRPRAEVAN	GALNT17	36	Q6IS24
VHFDLPGQEERARLV	ATAD3C	296	Q5T2N8
RRTFLHAVDVVLDPD	BTN2A1	321	Q7KYR7
HVDGEPGDLRFRIKV	DNAJB11	231	Q9UBS4
QKIPADGVHRIRVDF	KMT2A	1391	Q03164
HDGAQPLRVLFRRLE	FAM90A20P	386	A6NIJ5
PRFDHLVAIERAGRA	DGLUCY	426	Q7Z3D6
RDNHFAIFIIPQGRE	METTL13	296	Q8N6R0
HDGAQPLRVLFRRLE	FAM90A5P	386	A8MXJ8
RLVPGRHDIAFVEFE	SNRPB2	181	P08579
QAHGLPLDGEERVVF	SAC3D1	341	A6NKF1
LLIDRDPEGAVAHAQ	POLD1	851	P28340
TQLHRGLEARPEVVL	CDH3	716	P22223
HDGAQPLRVLFRRLE	FAM90A24P	386	P0C7X0
RRHIVAAGFLIVDVP	TBRG4	586	Q969Z0
VIHAFRRAVDDPGLV	OSGIN1	311	Q9UJX0
RHGPIQVEFVSADLE	PTPRM	1306	P28827
RRDLIFSVHDIPLGA	NYNRIN	1541	Q9P2P1
APKEEHVRRGQLADV	OGT	906	O15294
VQERDPRAHRFLGLL	RGPD1	46	P0DJD0
ERPQAHRLFVLVDGR	RIN3	916	Q8TB24
DLADRLVRVHGDPAV	FUT8	311	Q9BYC5
HDDLQRARFICPVVG	RTF2	111	Q9BY42
PIHDLDFVGRVLEAV	TRMT1	401	Q9NXH9
REIELKNRHGLVPFA	SRSF9	41	Q13242
FPVEFVRHGDIIRLE	POMT2	401	Q9UKY4
VNILERGLHPFVRTE	TBC1D21	51	Q8IYX1
RFARIVGPVEHDKFI	TADA2A	256	O75478
AQGRDFHLRIVLPED	FANCL	31	Q9NW38
RHFIDDVQLPLGLAV	RFLNB	116	Q8N5W9
HDGAQPLRVLFRRLE	FAM90A12P	386	A8MX19
IVLDRVPAFRDEHLQ	FBXL12	156	Q9NXK8
HDGAQPLRVLFRRLE	FAM90A9	386	A6NNJ1
HDGAQPLRVLFRRLE	FAM90A13P	386	P0C7W8
HDGAQPLRVLFRRLE	FAM90A26	386	D6RGX4
PDEEVQEETRGRFHL	SIGLEC6	81	O43699
LGRHEEVLPFAERLQ	SH3TC2	646	Q8TF17
PVFQDIRLHIREVGA	SCP2D1	46	Q9UJQ7
PFILDEIGADVQARH	PYCR2	76	Q96C36
ERQPEAELGRLLFQH	RNF216	196	Q9NWF9
PREVREFNGQHFILE	OXCT1	186	P55809
LVRELFRVAEEHAPS	PSMC1	266	P62191
RDVAHFGIRVSIVEP	RDH5	191	Q92781
QEETRDRFHLLGDPQ	SIGLEC12	86	Q96PQ1
HDGAQPLRVLFRRLE	FAM90A15P	386	P0C7V4
PHQVDLRTARVFLEV	HHIP	331	Q96QV1
PAGAIHFQREREEET	OS9	76	Q13438
FNGPHLLLRAVRDIE	SMYD3	216	Q9H7B4
VRVLVARLGHFAPVD	RIOX1	481	Q9H6W3
PVIRDHVQETRLGFF	RRP12	571	Q5JTH9
GELIRNHREQDVVPF	SHANK1	396	Q9Y566
RDPAQDLLAGDVIVH	B3GNT9	246	Q6UX72
DLLAGDVIVHARPIR	B3GNT9	251	Q6UX72
VHFDLPQQEERERLV	ATAD3B	471	Q5T9A4
LHRVRELPELFLGQS	CITED4	151	Q96RK1
VKAHVAELERRFPGA	CHPF	566	Q8IZ52
LRPVHRQLGEANEEF	AUP1	226	Q9Y679
DPVVEEHFRRSLGKN	VGLL4	206	Q14135
EPAGLHEVQDFLGRI	STYK1	151	Q6J9G0
REQGREHRVVAPTFV	TNRC18	361	O15417
LARFREEHPDLDQKG	UBTFL6	171	P0CB48
FLERRDLIIQHIPGF	TSPYL2	251	Q9H2G4
NERGHVDIATARPLI	WDFY3	2226	Q8IZQ1
LHRRILEEAQEDFPV	TRPM5	146	Q9NZQ8
RPEALAVELARHQNG	PHF21B	6	Q96EK2
VNHDPAVGDRLRVIF	PYGM	631	P11217
DVVCETPFRLHGRDL	SLITRK5	261	O94991
AFVEVGHRAEEPVLR	SEMA3B	141	Q13214
VGRFIHLLRSEDPDQ	VPS35	491	Q96QK1
VELERLRHIGPEEFV	RASGEF1C	211	Q8N431
DVLANVFREELLPHL	TNPO2	381	O14787
EGNVAPVRISERLHL	ZNF408	141	Q9H9D4
DHNRLVVREFENLPG	TTBK2	761	Q6IQ55
NHGRRIPKDVVEEFS	SMOX	126	Q9NWM0
LRDRIPFAVVGADQE	SEPTIN12	241	Q8IYM1
GETIFEIDPHLQERV	SUFU	241	Q9UMX1
EITPEIIGRHRFNTE	XYLB	381	O75191
EAPEERHFLRALELQ	YJEFN3	11	A6XGL0
LPEALDFVGVHQERT	NUP188	1416	Q5SRE5
REAHFVRTNGKEPEL	RPL21	136	P46778
RREIQAHGPRLEEVL	SPTBN4	1561	Q9H254
DDARIVQRHLPFEGG	STAB1	1841	Q9NY15
LLERIGIARPEEEFH	VPS13C	2566	Q709C8
NIHDDPIRLFGLIRA	TRAT1	166	Q6PIZ9
EILGHTPRVEDVLQR	SPTB	1526	P11277
LQRRHEGFERDLVPL	SPTA1	1221	P02549
ALLGDRAFLIEPEHV	VCPIP1	161	Q96JH7
LVQVYPDGIRHIRAD	SF3B3	516	Q15393
ILIRHREDIPFDGTN	RWDD2B	251	P57060
RQRFPAQGSIEIHED	PITPNM3	101	Q9BZ71
IRHIQPGAFDTLDRL	VASN	136	Q6EMK4
REHPFLVKGGEDLRQ	PRKDC	3746	P78527
HDDRGPVLEALVARA	SNRNP200	621	O75643
IDGEELRVIPCTHRF	ZNRF3	301	Q9ULT6
LRGPDEEGVHEINFL	TRAPPC8	1036	Q9Y2L5
GHPRALVRQAAVEDL	ZNF831	556	Q5JPB2
EIFRGLHEDLQGVPE	VTI1B	16	Q9UEU0
VDPEGVVRTKDHRFE	SHC1	536	P29353
EVRLVPGRHDIAFVE	SNRPA	236	P09012
GVVLEPFRLEHNLAV	ZMIZ1	571	Q9ULJ6
HDGAQPLRVLFRRLE	FAM90A18	386	P0DV75
LHGQRELRRFELPFD	KMT2D	76	O14686
AKQPGRFDEVLIRHQ	MYO1C	631	O00159