Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PLAC	ADAMTS16 ADAMTS19	5.30e-04	14	46	2	PF08686
Domain	PLAC	ADAMTS16 ADAMTS19	9.88e-04	19	46	2	PS50900
Domain	PLAC	ADAMTS16 ADAMTS19	9.88e-04	19	46	2	IPR010909
Domain	-	RLF ZNF227 ZFP3 ZSCAN31 ZNF548 ZNF639 ZNF646	1.27e-03	679	46	7	3.30.160.60
Domain	zf-C2H2	RLF ZNF227 ZFP3 ZSCAN31 ZNF548 ZNF639 ZNF646	1.43e-03	693	46	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	RLF ZNF227 ZFP3 ZSCAN31 ZNF548 ZNF639 ZNF646	1.44e-03	694	46	7	IPR013087
Domain	ADAM_spacer1	ADAMTS16 ADAMTS19	1.45e-03	23	46	2	IPR010294
Domain	ADAM_spacer1	ADAMTS16 ADAMTS19	1.45e-03	23	46	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS16 ADAMTS19	1.58e-03	24	46	2	IPR013273
Domain	ZINC_FINGER_C2H2_2	RLF ZNF227 ZFP3 ZSCAN31 ZNF548 ZNF639 ZNF646	2.69e-03	775	46	7	PS50157
Domain	ZINC_FINGER_C2H2_1	RLF ZNF227 ZFP3 ZSCAN31 ZNF548 ZNF639 ZNF646	2.73e-03	777	46	7	PS00028
Domain	Znf_C2H2-like	RLF ZNF227 ZFP3 ZSCAN31 ZNF548 ZNF639 ZNF646	3.12e-03	796	46	7	IPR015880
Domain	Znf_C2H2	RLF ZNF227 ZFP3 ZSCAN31 ZNF548 ZNF639 ZNF646	3.32e-03	805	46	7	IPR007087
Domain	ZnF_C2H2	RLF ZNF227 ZFP3 ZSCAN31 ZNF548 ZNF639 ZNF646	3.39e-03	808	46	7	SM00355
Domain	Peptidase_M12B_N	ADAMTS16 ADAMTS19	4.15e-03	39	46	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS16 ADAMTS19	4.15e-03	39	46	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS16 ADAMTS19	4.36e-03	40	46	2	PS00427
Domain	Reprolysin	ADAMTS16 ADAMTS19	4.36e-03	40	46	2	PF01421
Domain	ADAM_MEPRO	ADAMTS16 ADAMTS19	4.36e-03	40	46	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS16 ADAMTS19	4.36e-03	40	46	2	PS50214
Domain	Peptidase_M12B	ADAMTS16 ADAMTS19	4.36e-03	40	46	2	IPR001590
Domain	CYSTEINE_SWITCH	ADAMTS16 ADAMTS19	4.58e-03	41	46	2	PS00546
Domain	Disintegrin_dom	ADAMTS16 ADAMTS19	4.58e-03	41	46	2	IPR001762
Domain	-	TRIM72 MTMR4 TRIM51 RNF6 USP16	4.78e-03	449	46	5	3.30.40.10
Domain	Pept_M10_metallopeptidase	ADAMTS16 ADAMTS19	5.03e-03	43	46	2	IPR001818
Domain	Znf_RING/FYVE/PHD	TRIM72 MTMR4 TRIM51 RNF6 USP16	5.25e-03	459	46	5	IPR013083
Domain	zf-C2H2_6	ZNF227 ZSCAN31 ZNF548 ZNF646	7.34e-03	314	46	4	PF13912
Domain	Znf_C3HC4_RING-type	TRIM72 TRIM51 RNF6	8.72e-03	172	46	3	IPR018957
Pubmed	Urinary Cell-Free DNA IQGAP3/BMP4 Ratio as a Prognostic Marker for Non-Muscle-Invasive Bladder Cancer.	BMP4 IQGAP3	1.71e-06	2	46	2	31088707
Pubmed	Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria.	BMP4 IQGAP3	5.13e-06	3	46	2	30446454
Pubmed	ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.	ADAMTS16 ADAMTS19	1.03e-05	4	46	2	28088271
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS16 ADAMTS19	3.58e-05	7	46	2	11867212
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS16 ADAMTS19 BMP4	1.37e-04	75	46	3	20637190
Pubmed	Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease.	ADAMTS16 BMP4	1.54e-04	14	46	2	31242448
Pubmed	New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.	HRC BMP4	1.54e-04	14	46	2	11526197
Pubmed	The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters.	ADAMTS16 BMP4	1.78e-04	15	46	2	7543410
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LTBP3 CNTRL ARHGAP19	1.98e-04	85	46	3	15449545
Pubmed	Lhx2 maintains stem cell character in hair follicles.	BMP4 ITGB4	2.03e-04	16	46	2	16809539
Pubmed	Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells.	ADAMTS16 TRANK1	2.88e-04	19	46	2	25855264
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PPIP5K1 TRANK1 ZNF646	3.59e-04	104	46	3	9205841
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	RIOK1 LIMCH1 TRANK1 HSPA4L DOCK9	4.94e-04	497	46	5	36774506
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	LIMCH1 ITGB4 PPL	5.20e-04	118	46	3	30979931
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKRD13D BMP4 LTBP3 CTC1 ITGB4 IQGAP3 DOCK9	5.81e-04	1105	46	7	35748872
Pubmed	SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166.	BMP4 TACC2	6.33e-04	28	46	2	32801337
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	RIOK1 LIMCH1 HSPA4L USP16 ARHGAP19	7.61e-04	547	46	5	37267103
Pubmed	Functional proteomics mapping of a human signaling pathway.	RLF BMP4 LTBP3 MTMR4 PPL	1.07e-03	591	46	5	15231748
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	ADAMTS16 BMP4	1.11e-03	37	46	2	34323105
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	ANKRD13D RIOK1 TOP1MT PRMT7 IQGAP3	1.18e-03	604	46	5	38803224
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ANKRD13D ITGB4 PPL ZNF639 ARHGAP19	1.22e-03	608	46	5	16713569
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	CCSAP LIMCH1 LTBP3 ITGB4 DOCK9 IQSEC2	1.32e-03	925	46	6	28986522
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	RLF ZNF227 ZFP3 ZSCAN31 ZNF548 ZNF639 ZNF646	3.85e-04	718	35	7	28
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS16 ADAMTS19	6.10e-04	19	35	2	50
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 CTC1 HSPA4L CNTRL	2.08e-05	157	46	4	f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BMP4 ITGB4 IQGAP3 DOCK9	2.90e-05	171	46	4	1597459c971d6befa991d59dc66b41b6a522f797
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	FBXW8 TRANK1 ZNF548 PPL	3.04e-05	173	46	4	42c911ed16fabdabef063830e8407192d8bde950
ToppCell	ASK454-Epithelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	TACC2 LIMCH1 LTBP3 PPL	3.70e-05	182	46	4	ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ADAMTS16 ADAMTS19 BMP4 PAMR1	4.29e-05	189	46	4	c392491aabe8a3e90974ab2ea123bbbe5200439d
ToppCell	droplet-Lung-immune-endo-depleted\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 LIMCH1 LTBP3 PAMR1	4.29e-05	189	46	4	c3fb363bb0156ffb3367c200f548faebda64ab4a
ToppCell	droplet-Lung-immune-endo-depleted-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 LIMCH1 LTBP3 PAMR1	4.29e-05	189	46	4	2a2953f6b1b7d070d739dcaf7285fce6e097d9e4
ToppCell	droplet-Lung-3m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMP4 LIMCH1 LTBP3 PAMR1	4.29e-05	189	46	4	5a636e952da9b1fd26aa17f7b129054f2da322b5
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 LIMCH1 LTBP3 PAMR1	4.38e-05	190	46	4	9cd147a174017ebda23cc47b6d4552d898acd092
ToppCell	droplet-Lung-1m-Mesenchymal\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMP4 LIMCH1 LTBP3 PAMR1	4.56e-05	192	46	4	01433bd4794b8bcc51fe4249124a0f4289b9d6e2
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TACC2 LIMCH1 ITGB4 PPL	4.65e-05	193	46	4	a5695ce2e24a62026ae28f3dea07ca4a435206b8
Disease	Amelogenesis Imperfecta	LTBP3 ITGB4	1.55e-04	12	46	2	C0002452
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR4 GDAP1	6.42e-04	24	46	2	DOID:10595 (implicated_via_orthology)
Disease	optic disc size measurement	BMP4 LIMCH1 CADPS	4.03e-03	205	46	3	EFO_0004832
Disease	magnesium measurement	ADAMTS19 PRMT7	4.79e-03	66	46	2	EFO_0004845

Protein segments in the cluster

Peptide	Gene	Start	Entry
LHCNVPEHHNLENEV	CNTRL	1311	Q7Z7A1
LHSHQHDIEQEDPRG	ANKRD13D	26	Q6ZTN6
VRNAHNEILEEPHHC	CTC1	521	Q2NKJ3
THNVCASAPVHEIHE	CCSAP	201	Q6IQ19
HHEEHLENIPGTSEN	BMP4	121	P12644
PEEFVAAGDHLVHHC	ATG3	36	Q9NT62
EDEQPGLVISHHADH	ADAMTS16	346	Q8TE57
NHDNDHPSCADGLHI	ADAMTS19	491	Q8TE59
NEEHHAEPHVDKGEA	CADPS	896	Q9ULU8
HIDIHPENTHILDGN	GNPDA1	96	P46926
ERDVAQCHLHHENPA	IQSEC2	151	Q5JU85
GSHSDHPEINCHKVV	KIAA2026	646	Q5HYC2
EHVPDTVLCDVHSHD	FBXW8	206	Q8N3Y1
ACAQPDHLDHIIPDH	PDCD2	171	Q16342
QEHCPDLERQEAEVH	PPL	691	O60437
CEEHDVSLPLSEHNE	GDAP1	51	Q8TB36
EHVDGTHVCQLPEDQ	ITGB4	416	P16144
HQDCIAPDHQDPLHE	IQGAP3	1296	Q86VI3
EEDQHTHLCQPGEHI	MTMR4	141	Q9NYA4
PVHNSEIQETCDAHH	FRG2B	131	Q96QU4
IHVVAQCHEEGLESH	DOCK9	896	Q9BZ29
HAHRHLVEENCEAVP	PRMT7	161	Q9NVM4
TQDQHGCEEVEQPHH	LTBP3	901	Q9NS15
APNHVHEVCLHQVES	LSMEM2	36	Q8N112
HEDHQLDTEAGAPHC	LIMCH1	916	Q9UPQ0
DSLLCEEQHEDHGIP	PAMR1	626	Q6UXH9
DVSQSVEHDHPHALE	RIOK1	341	Q9BRS2
PHHENEIAQCEVFHQ	CARS2	281	Q9HA77
GSEETLPQDHNHHEN	RNF6	11	Q9Y252
PQHVHHGLVDEEEEE	HRC	366	P23327
NQAPDHEHGHSEVLL	ZSCAN31	126	Q96LW9
FCEHETNDPEDLHSH	ZNF639	321	Q9UID6
HLNDICTIDHPEDSE	USP16	466	Q9Y5T5
KHCSDSHNLDHIEEP	RLF	1381	Q13129
VDQEEGHQKCHAEHT	HSPA4L	531	O95757
GHQKCHAEHTPEEEI	HSPA4L	536	O95757
SNSQEHRNHIHCPIE	TRIM51	116	Q9BSJ1
AAPHTDQDHVCKHEE	ZNF646	546	O15015
EHVQLHPEADGCQHV	TOP1MT	346	Q969P6
LEEGSQHEEACQRHP	TACC2	1001	O95359
VDSCPHQEETQHHTE	ARHGAP19	356	Q14CB8
EGLAQVPQGHCEEHL	TRIM72	76	Q6ZMU5
ILCLVEHNGIHPEQH	ZNF548	96	Q8NEK5
HQRVHTGEKPHICEE	ZNF227	706	Q86WZ6
AAEVCAPEHPHQLEH	TRANK1	1131	O15050
QVEHEGEFTCHARHP	SIGLEC10	416	Q96LC7
ENHDNGNHTCQEVPH	PPIP5K1	1291	Q6PFW1
HQRIHTGEKPHQCNE	ZFP3	411	Q96NJ6