Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

SOX7 FOXD3 CDX4 HOXD9 NFKB1 ZBTB22 NKX2-3 SKOR1 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TAL1 CIC TLX1

6.86e-0514128417GO:0000981
GeneOntologyMolecularFunctionmolecular adaptor activity

SHANK1 YEATS2 DNAJB1 TOMM70 ASXL1 TOB2 MAP2K4 MYOZ1 YBX1 NFKB1 SMARCC1 DYNC1LI1 IRS1 IRS2 KAT2A VCP

1.47e-0413568416GO:0060090
GeneOntologyMolecularFunctionG protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

KCTD12 GRM5

1.73e-045842GO:0099530
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

SOX7 FOXD3 CDX4 HOXD9 NFKB1 ZBTB22 NKX2-3 SKOR1 ZFHX2 POU2F2 ZFHX3 EN1 EN2 TAL1 TLX1

1.93e-0412448415GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

SOX7 FOXD3 CDX4 HOXD9 NFKB1 ZBTB22 NKX2-3 SKOR1 ZFHX2 POU2F2 ZFHX3 EN1 EN2 TAL1 TLX1

2.44e-0412718415GO:0000987
GeneOntologyMolecularFunctioninsulin receptor binding

IRS4 IRS1 IRS2

2.69e-0430843GO:0005158
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

SHANK1 YEATS2 DNAJB1 ASXL1 TOB2 MYOZ1 YBX1 NFKB1 SMARCC1 DYNC1LI1 IRS1 IRS2 KAT2A VCP

3.21e-0411608414GO:0030674
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

SOX7 FOXD3 CDX4 HOXD9 NFKB1 ZBTB22 NKX2-3 SKOR1 ZFHX2 POU2F2 ZFHX3 EN1 EN2 TAL1 CIC TLX1

3.37e-0414598416GO:0000977
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase activator activity

IRS1 IRS2

6.18e-049842GO:0141038
GeneOntologyMolecularFunctionK48-linked polyubiquitin modification-dependent protein binding

UBQLN4 VCP

7.70e-0410842GO:0036435
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

IRS4 IRS1 IRS2

7.85e-0443843GO:0043548
GeneOntologyMolecularFunctionactinin binding

MAGI1 MYOZ1 NFKB1

7.85e-0443843GO:0042805
GeneOntologyMolecularFunctionsignaling receptor complex adaptor activity

SHANK1 IRS1 IRS2

1.53e-0354843GO:0030159
GeneOntologyMolecularFunctionprotein serine/threonine phosphatase inhibitor activity

PABIR1 MYOZ1

1.77e-0315842GO:0004865
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase regulator activity

IRS1 IRS2

2.56e-0318842GO:0035014
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase adaptor activity

IRS1 IRS2

2.56e-0318842GO:0005068
GeneOntologyBiologicalProcessregulation of ubiquitin-dependent protein catabolic process

PABIR1 TRIM67 UBQLN4 SMARCC1 SH3RF3 GSK3A VCP ANKS1A

8.00e-07185838GO:2000058
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

SOX7 ASXL1 FOXD3 CDX4 HOXD9 YBX1 SUPT5H NFKB1 NKX2-3 SMARCC1 POU2F2 ZFHX3 KAT2A SPAG8 EN1 EN2 TAL1 GSK3A TLX1

1.97e-0613908319GO:0045944
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

YEATS2 DNAJB1 SOX7 FOXD3 TOB2 CDX4 MYOZ1 HOXD9 YBX1 SUPT5H TRO NFKB1 SKOR1 ZFHX3 KAT2A EN1 TAL1 CIC RING1

2.17e-0613998319GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

YEATS2 DNAJB1 SOX7 FOXD3 TOB2 CDX4 MYOZ1 HOXD9 YBX1 SUPT5H TRO NFKB1 SKOR1 ZFHX3 KAT2A EN1 TAL1 CIC RING1

2.51e-0614138319GO:1902679
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

YEATS2 DNAJB1 FOXD3 CDX4 MYOZ1 HOXD9 YBX1 SUPT5H TRO NFKB1 SKOR1 ZFHX3 KAT2A EN1 TAL1 CIC

3.89e-0610538316GO:0000122
GeneOntologyBiologicalProcessregulation of proteolysis involved in protein catabolic process

PABIR1 TRIM67 UBQLN4 SMARCC1 SH3RF3 GSK3A VCP ANKS1A

8.67e-06255838GO:1903050
GeneOntologyBiologicalProcessregulation of stem cell population maintenance

BICRA SMARCC1 KAT2A TAL1 CNOT3

1.57e-0578835GO:2000036
GeneOntologyBiologicalProcessregulation of proteasomal ubiquitin-dependent protein catabolic process

PABIR1 UBQLN4 SMARCC1 SH3RF3 GSK3A VCP

2.07e-05139836GO:0032434
GeneOntologyBiologicalProcessregulation of polysaccharide biosynthetic process

NFKB1 IRS1 IRS2 GSK3A

3.81e-0547834GO:0032885
GeneOntologyBiologicalProcessregulation of polysaccharide metabolic process

NFKB1 IRS1 IRS2 GSK3A

8.77e-0558834GO:0032881
GeneOntologyBiologicalProcesspositive regulation of ubiquitin-dependent protein catabolic process

PABIR1 TRIM67 SH3RF3 GSK3A VCP

9.73e-05114835GO:2000060
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

NFKB1 IRS1 IRS2 KAT2A GSK3A

1.94e-04132835GO:0043255
GeneOntologyBiologicalProcessregulation of proteasomal protein catabolic process

PABIR1 UBQLN4 SMARCC1 SH3RF3 GSK3A VCP

2.20e-04213836GO:0061136
GeneOntologyBiologicalProcesspolysaccharide biosynthetic process

NFKB1 IRS1 IRS2 GSK3A

2.51e-0476834GO:0000271
GeneOntologyBiologicalProcessinclusion body assembly

DNAJB1 HSPA2 VCP

3.14e-0433833GO:0070841
GeneOntologyBiologicalProcesslymph node development

NFKB1 NKX2-3 TLX1

3.14e-0433833GO:0048535
GeneOntologyBiologicalProcesspositive regulation of proteolysis involved in protein catabolic process

PABIR1 TRIM67 SH3RF3 GSK3A VCP

3.29e-04148835GO:1903052
GeneOntologyBiologicalProcesspositive regulation of proteasomal ubiquitin-dependent protein catabolic process

PABIR1 SH3RF3 GSK3A VCP

3.85e-0485834GO:0032436
GeneOntologyBiologicalProcessinsulin receptor signaling pathway

IRS4 SMARCC1 IRS1 IRS2 GSK3A

4.19e-04156835GO:0008286
GeneOntologyBiologicalProcessregulation of catabolic process

PABIR1 RASIP1 TRIM67 YBX1 SUPT5H UBQLN4 SMARCC1 IRS1 IRS2 SH3RF3 CNOT3 GSK3A VCP ANKS1A

4.41e-0412528314GO:0009894
GeneOntologyBiologicalProcessregulation of glycogen biosynthetic process

IRS1 IRS2 GSK3A

4.79e-0438833GO:0005979
GeneOntologyBiologicalProcessregulation of glucan biosynthetic process

IRS1 IRS2 GSK3A

4.79e-0438833GO:0010962
GeneOntologyBiologicalProcesspositive regulation of catabolic process

PABIR1 TRIM67 YBX1 SUPT5H IRS1 IRS2 SH3RF3 CNOT3 GSK3A VCP

5.01e-047018310GO:0009896
GeneOntologyCellularComponentchromatin

YEATS2 SOX7 FOXD3 CDX4 HOXD9 BICRA NFKB1 ZBTB22 NKX2-3 SMARCC1 ZFHX2 GSX2 POU2F2 ZFHX3 KAT2A EN1 EN2 TAL1 CIC TLX1 RING1

1.72e-0714808221GO:0000785
MousePhenoabnormal presacral vertebrae morphology

ASXL1 CDX4 MYOZ1 HOXD9 LTBP3 KAT2A GSK3A RING1

2.17e-05225738MP:0000459
MousePhenovertebral transformation

ASXL1 CDX4 HOXD9 SUPT5H KAT2A RING1

2.30e-05110736MP:0003036
MousePhenoabnormal osteoclast cell number

TOB2 NFKB1 IRS1 CNOT3 TMEM64 VCP

5.40e-05128736MP:0004983
MousePhenoabnormal osteoclast differentiation

TOB2 IRS1 CNOT3 TMEM64 VCP

8.01e-0585735MP:0008396
DomainHomeobox_CS

CDX4 HOXD9 NKX2-3 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TLX1

1.23e-081868510IPR017970
Domain-

CDX4 HOXD9 NKX2-3 SMARCC1 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TLX1

6.29e-0828385111.10.10.60
DomainHomeodomain_engrailed

EN1 EN2 TLX1

9.10e-083853IPR000747
DomainHomeobox

CDX4 HOXD9 NKX2-3 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TLX1

1.08e-072348510PF00046
DomainHOMEOBOX_1

CDX4 HOXD9 NKX2-3 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TLX1

1.17e-072368510PS00027
DomainHOX

CDX4 HOXD9 NKX2-3 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TLX1

1.22e-072378510SM00389
DomainHOMEOBOX_2

CDX4 HOXD9 NKX2-3 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TLX1

1.32e-072398510PS50071
DomainHomeobox_dom

CDX4 HOXD9 NKX2-3 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TLX1

1.32e-072398510IPR001356
DomainHomeobox_metazoa

CDX4 HOXD9 NKX2-3 GSX2 EN1 EN2 TLX1

1.73e-0790857IPR020479
DomainHomeodomain-like

CDX4 HOXD9 NKX2-3 SMARCC1 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TLX1

3.14e-073328511IPR009057
DomainPTBI

IRS4 IRS1 IRS2

1.46e-0511853SM00310
DomainHTH_motif

CDX4 HOXD9 NKX2-3 EN1 EN2

1.55e-0569855IPR000047
DomainIRS_PTB

IRS4 IRS1 IRS2

1.94e-0512853PS51064
DomainEngrail_1_C_sig

EN1 EN2

2.05e-052852PF10525
DomainHomeobox-engrailed_C-terminal

EN1 EN2

2.05e-052852IPR019549
DomainHomoebox-engrailed_CS

EN1 EN2

2.05e-052852IPR019737
DomainENGRAILED

EN1 EN2

2.05e-052852PS00033
DomainIRS_PTB

IRS4 IRS1 IRS2

3.19e-0514853IPR002404
DomainIRS

IRS4 IRS1 IRS2

3.19e-0514853PF02174
DomainAnk

SHANK1 NFKB1 ANKHD1 SOWAHC ANKS1A

3.86e-03228855PF00023
DomainANK

SHANK1 NFKB1 ANKHD1 SOWAHC ANKS1A

5.77e-03251855SM00248
DomainANK_REPEAT

SHANK1 NFKB1 ANKHD1 SOWAHC ANKS1A

5.97e-03253855PS50088
DomainAnkyrin_rpt-contain_dom

SHANK1 NFKB1 ANKHD1 SOWAHC ANKS1A

6.07e-03254855IPR020683
DomainANK_REP_REGION

SHANK1 NFKB1 ANKHD1 SOWAHC ANKS1A

6.07e-03254855PS50297
DomainAnkyrin_rpt

SHANK1 NFKB1 ANKHD1 SOWAHC ANKS1A

6.89e-03262855IPR002110
DomainZnF_U1

ZFHX2 ZFHX3

7.67e-0329852SM00451
DomainZnf_U1

ZFHX2 ZFHX3

7.67e-0329852IPR003604
DomainLRR_8

LRCH2 LRRC4B SLITRK3 LGR6

7.73e-03171854PF13855
DomainLeu-rich_rpt_typical-subtyp

LRCH2 LRRC4B SLITRK3 LGR6

8.70e-03177854IPR003591
DomainLRR_TYP

LRCH2 LRRC4B SLITRK3 LGR6

8.70e-03177854SM00369
DomainRA

RASIP1 RGL2

8.74e-0331852SM00314
PathwayWP_LEPTININSULIN_SIGNALING_OVERLAP

IRS4 IRS1 IRS2

3.48e-0517543M39517
PathwaySIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES

IRS4 IRS1 IRS2 GSK3A

4.20e-0551544M7955
PathwayWP_LEPTININSULIN_SIGNALING_OVERLAP

IRS4 IRS1 IRS2

5.78e-0520543MM15867
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

SHANK1 LRRC4B SLITRK3 GRM5

1.23e-0467544MM15327
PathwayKEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY

IRS4 NFKB1 IRS1 IRS2

1.23e-0467544M10462
PathwaySIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES

IRS4 IRS1 IRS2 GSK3A

1.23e-0467544M295
PathwayREACTOME_IRS_ACTIVATION

IRS1 IRS2

1.43e-045542M27707
PathwaySIG_IL4RECEPTOR_IN_B_LYPHOCYTES

IRS1 IRS2 GSK3A

1.46e-0427543M1718
PathwayWP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY

MAP2K4 IRS4 IRS1 IRS2 GSK3A

1.46e-04132545M39338
PathwayREACTOME_SOS_MEDIATED_SIGNALLING

IRS1 IRS2

2.99e-047542M19489
PathwayWP_IL2_SIGNALING_PATHWAY

YBX1 NFKB1 IRS1 IRS2

3.38e-0487544MM15915
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

SHANK1 LRRC4B SLITRK3 GRM5

3.38e-0487544M27617
PathwayWP_INSULIN_SIGNALING

MAP2K4 IRS4 IRS1 IRS2 GSK3A

3.57e-04160545M39482
PathwayREACTOME_PI3K_AKT_ACTIVATION

IRS1 IRS2

5.10e-049542M714
PathwayKEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION

IRS4 IRS1 IRS2

5.49e-0442543M16473
PathwayREACTOME_SIGNAL_ATTENUATION

IRS1 IRS2

6.35e-0410542M14236
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

IRS4 IRS1 IRS2

7.65e-0447543M19708
PathwayREACTOME_SIGNALING_BY_LEPTIN

IRS1 IRS2

7.75e-0411542M27195
Pubmed

A census of human transcription factors: function, expression and evolution.

YEATS2 SOX7 FOXD3 CDX4 HOXD9 YBX1 NFKB1 NKX2-3 SKOR1 ZFHX2 GSX2 POU2F2 ZFHX3 EN1 EN2 TAL1 CIC TLX1

6.28e-12908851819274049
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

SOX7 FOXD3 CDX4 HOXD9 YBX1 ZBTB22 NKX2-3 SKOR1 GSX2 POU2F2 EN1 EN2

8.88e-09544851228473536
Pubmed

Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries.

IRS4 IRS1 IRS2

1.41e-08385315155816
Pubmed

Human transcription factor protein interaction networks.

YEATS2 ASXL1 IRS4 YBX1 BICRA NFKB1 MARF1 SMARCC1 ZFHX3 KAT2A ANKHD1 EN1 TAL1 CIC CNOT3 TLX1 RING1

5.58e-081429851735140242
Pubmed

53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.

IRS4 IRS1 IRS2

5.63e-08485317965023
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SHANK1 KCTD12 MAGI1 MAP2K4 TRIM67 LRCH2 LZTS3 PRR36 ZBTB22 HNRNPM SMARCC1 GRM5 NEURL4 ANKS1A

8.69e-08963851428671696
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

SHANK1 KCTD12 MAP2K4 CACNG8 LZTS3 YBX1 HNRNPM USP24 DYNC1LI1 LRRC4B GRM5 HSPA2 CNOT3 GSK3A VCP

1.03e-071139851536417873
Pubmed

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.

IRS4 IRS1 IRS2

1.40e-07585318202124
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

SOX7 FOXD3 CDX4 NFKB1 ZBTB22 SMARCC1 ZFHX2 POU2F2 ZFHX3 KAT2A CIC RING1

1.59e-07709851222988430
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PABIR1 MAGI1 DNAJB1 IRS4 IRS1 IRS2 TRAPPC14 RGL2 SH3RF3 CIC GSK3A RUSC2 ANKS1A

1.71e-07861851336931259
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

SOX7 FOXD3 CDX4 ZFHX2 POU2F2 ZFHX3 EN2 CIC

2.80e-0726385820932939
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

YEATS2 ASXL1 IRS4 LZTS3 YBX1 SUPT5H NFKB1 HNRNPM SMARCC1 DYNC1LI1 EN2 HSPA2 VCP

3.73e-07922851327609421
Pubmed

Differential roles of insulin receptor substrates in brown adipocyte differentiation.

IRS4 IRS1 IRS2

4.90e-07785314966273
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

SHANK1 CACNG8 LZTS3 LRRC4B SH3RF3 VCP RING1

5.71e-0719785736604605
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

YEATS2 TOMM70 ASXL1 TOB2 LRCH2 TRO CDK19 ZSWIM6 RUSC2

7.08e-0740785912693553
Pubmed

IRS2 signalling is required for the development of a subset of sensory spinal neurons.

IRS4 IRS1 IRS2

1.17e-06985322288475
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

CDX4 HOXD9 SUPT5H NFKB1 ZBTB22 NKX2-3 GSX2 SOWAHC TAL1 CIC CNOT3 TLX1

1.49e-06877851220211142
Pubmed

Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.

IRS4 IRS1 IRS2

1.67e-061085320416304
Pubmed

Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.

IRS4 IRS1 IRS2

1.67e-061085321852217
Pubmed

Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.

ZBTB22 HNRNPM RGL2 RING1

1.84e-063685415112104
Pubmed

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.

DNAJB1 YBX1 HNRNPM ANKHD1 HSPA2 VCP

2.41e-0615685632850835
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

YEATS2 PACS1 USP24 SMARCC1 DYNC1LI1 IRS2 ADARB1 CIC CNOT3 GSK3A ANKS1A

2.95e-06774851115302935
Pubmed

Insulin receptor substrate 4 associates with the protein IRAS.

IRS4 IRS1 IRS2

3.05e-061285311912194
Pubmed

Isoform-specific GSK3A activity is negatively correlated with human sperm motility.

DNAJB1 YBX1 HNRNPM HSPA2 GSK3A

3.22e-069285530824926
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

TRO CDK19 USP24 ZFHX2 ANKHD1

5.89e-0610485510470851
Pubmed

Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2.

IRS1 IRS2

5.90e-06285217222321
Pubmed

Characterization of the Engrailed mutant mice as experimental models for Parkinson's disease.

EN1 EN2

5.90e-06285218585948
Pubmed

Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics.

IRS1 IRS2

5.90e-06285233270683
Pubmed

Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.

MAP2K4 NFKB1

5.90e-06285216167336
Pubmed

Behavioral, neurochemical, and electrophysiological changes in an early spontaneous mouse model of nigrostriatal degeneration.

EN1 EN2

5.90e-06285221104462
Pubmed

The mouse Engrailed genes: a window into autism.

EN1 EN2

5.90e-06285217055592
Pubmed

Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy.

NFKB1 USP24

5.90e-06285238056575
Pubmed

Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.

IRS1 IRS2

5.90e-06285215975995
Pubmed

Systematic modeling for the insulin signaling network mediated by IRS(1) and IRS(2).

IRS1 IRS2

5.90e-06285224703981
Pubmed

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.

IRS1 IRS2

5.90e-06285227708333
Pubmed

Impairment of bone healing by insulin receptor substrate-1 deficiency.

IRS1 IRS2

5.90e-06285214736890
Pubmed

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.

IRS1 IRS2

5.90e-06285221356519
Pubmed

The study on the relationship between IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms and type 2 diabetes in the Kurdish ethnic group in West Iran.

IRS1 IRS2

5.90e-06285222994406
Pubmed

Caspase-mediated Cleavage of Insulin Receptor Substrate.

IRS1 IRS2

5.90e-06285215069074
Pubmed

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.

IRS1 IRS2

5.90e-06285219596788
Pubmed

Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.

IRS1 IRS2

5.90e-06285219259821
Pubmed

Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.

IRS1 IRS2

5.90e-06285212810606
Pubmed

Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.

IRS1 IRS2

5.90e-06285211522686
Pubmed

Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians.

IRS1 IRS2

5.90e-06285234449768
Pubmed

Zonisamide reduces nigrostriatal dopaminergic neurodegeneration in a mouse genetic model of Parkinson's disease.

EN1 EN2

5.90e-06285225857446
Pubmed

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.

IRS1 IRS2

5.90e-06285229717275
Pubmed

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.

IRS1 IRS2

5.90e-06285211546755
Pubmed

Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.

IRS1 IRS2

5.90e-06285212475767
Pubmed

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

IRS1 IRS2

5.90e-06285211872698
Pubmed

Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.

IRS1 IRS2

5.90e-06285211259600
Pubmed

Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.

IRS1 IRS2

5.90e-06285212213887
Pubmed

Selective Insulin Resistance in the Kidney.

IRS1 IRS2

5.90e-06285227247938
Pubmed

Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression.

IRS1 IRS2

5.90e-06285231666286
Pubmed

Dissecting the role of Engrailed in adult dopaminergic neurons--Insights into Parkinson disease pathogenesis.

EN1 EN2

5.90e-06285226459030
Pubmed

Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.

IRS1 IRS2

5.90e-06285234537327
Pubmed

NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells.

NFKB1 TAL1

5.90e-06285216778171
Pubmed

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

IRS1 IRS2

5.90e-06285226991655
Pubmed

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.

IRS1 IRS2

5.90e-06285215572028
Pubmed

Chromosomal localization of the human homeo box-containing genes, EN1 and EN2.

EN1 EN2

5.90e-0628522567700
Pubmed

Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.

IRS1 IRS2

5.90e-06285225002528
Pubmed

Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2.

IRS1 IRS2

5.90e-06285224977713
Pubmed

Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.

IRS1 IRS2

5.90e-06285228003360
Pubmed

Novel Serine 176 Phosphorylation of YBX1 Activates NF-κB in Colon Cancer.

YBX1 NFKB1

5.90e-06285228077578
Pubmed

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

IRS1 IRS2

5.90e-06285211078455
Pubmed

PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates.

IRS1 IRS2

5.90e-06285221325637
Pubmed

Deregulated expression of PAX5 in medulloblastoma.

EN1 EN2

5.90e-0628527777574
Pubmed

Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.

IRS1 IRS2

5.90e-06285217374994
Pubmed

Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women.

IRS1 IRS2

5.90e-06285222205343
Pubmed

Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC).

IRS1 IRS2

5.90e-06285231393907
Pubmed

Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.

IRS1 IRS2

5.90e-06285224159000
Pubmed

Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.

IRS1 IRS2

5.90e-06285222688336
Pubmed

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.

IRS1 IRS2

5.90e-06285215467829
Pubmed

Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions.

EN1 EN2

5.90e-0628521363401
Pubmed

The double life of Irs.

IRS1 IRS2

5.90e-06285218590687
Pubmed

Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.

IRS1 IRS2

5.90e-06285218590692
Pubmed

A role for Engrailed-2 in determination of skeletal muscle physiologic properties.

EN1 EN2

5.90e-06285211180961
Pubmed

Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells.

IRS1 IRS2

5.90e-06285219447894
Pubmed

Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis.

IRS1 IRS2

5.90e-06285217361103
Pubmed

Disruption of IRS-2 causes type 2 diabetes in mice.

IRS1 IRS2

5.90e-0628529495343
Pubmed

Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice.

IRS1 IRS2

5.90e-06285237550630
Pubmed

Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.

IRS1 IRS2

5.90e-06285233839150
Pubmed

Anterior mesendoderm induces mouse Engrailed genes in explant cultures.

EN1 EN2

5.90e-0628528375331
Pubmed

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.

IRS1 IRS2

5.90e-06285217928362
Pubmed

Engrailed homeobox genes determine the organization of Purkinje cell sagittal stripe gene expression in the adult cerebellum.

EN1 EN2

5.90e-06285219020009
Pubmed

Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis.

EN1 EN2

5.90e-06285228809922
Pubmed

Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation-induced cell death.

IRS1 IRS2

5.90e-06285212055235
Pubmed

Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1.

EN1 EN2

5.90e-06285217267560
Pubmed

Irs1 serine 307 promotes insulin sensitivity in mice.

IRS1 IRS2

5.90e-06285220074531
Pubmed

Role of IRS-2 in insulin and cytokine signalling.

IRS1 IRS2

5.90e-0628527675087
Pubmed

Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis.

IRS1 IRS2

5.90e-06285222523112
Pubmed

Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.

IRS1 IRS2

5.90e-06285217641282
Pubmed

Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population.

IRS1 IRS2

5.90e-06285225310961
Pubmed

Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice.

EN1 EN2

5.90e-06285217015829
Pubmed

Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum.

EN1 EN2

5.90e-0628521680044
Pubmed

Association of IRS-1 and IRS-2 polymorphisms with predisposition to type-2 diabetes (T2D): a meta-analysis and trial sequential analysis.

IRS1 IRS2

5.90e-06285237173295
Pubmed

Conservation of engrailed-like homeobox sequences during vertebrate evolution.

EN1 EN2

5.90e-0628521980115
Pubmed

Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties.

EN1 EN2

5.90e-0628529169834
Pubmed

Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2.

EN1 EN2

5.90e-0628527624797
Pubmed

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.

IRS1 IRS2

5.90e-06285216374520
Pubmed

Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact?

IRS1 IRS2

5.90e-06285220210696
InteractionUSP7 interactions

FOXD3 CDX4 TRIM67 LRCH2 LZTS3 TRO FIGNL2 HNRNPM USP24 SMARCC1 ZFHX2 GSX2 IRS1 IRS2 TAL1 ADARB1 CIC VCP ANKS1A RING1

3.91e-0713138520int:USP7
InteractionRCOR1 interactions

YEATS2 IRS4 TRIM67 FAM110D USP24 SMARCC1 ZFHX3 ANKHD1 TAL1 CIC VCP TLX1

1.07e-064948512int:RCOR1
InteractionYWHAH interactions

PABIR1 MAGI1 DNAJB1 PACS1 IRS4 TRIM67 LRCH2 IRS1 IRS2 TRAPPC14 RGL2 SH3RF3 CIC GSK3A VCP RUSC2 ANKS1A

2.89e-0611028517int:YWHAH
InteractionYWHAG interactions

PABIR1 MAGI1 DNAJB1 PACS1 IRS4 TRIM67 HNRNPM USP24 IRS1 IRS2 TRAPPC14 RGL2 SH3RF3 CIC GSK3A VCP RUSC2 ANKS1A

3.62e-0612488518int:YWHAG
InteractionPRKCQ interactions

MAP2K4 TRIM67 IRS1 GRM5 TAL1

5.86e-0661855int:PRKCQ
InteractionKDM1A interactions

YEATS2 IRS4 TRIM67 SUPT5H FAM110D UBQLN4 USP24 SMARCC1 ZFHX3 IRS2 ANKHD1 TAL1 ADARB1 CIC CNOT3

8.22e-069418515int:KDM1A
InteractionPSMD8 interactions

ASXL1 TRIM67 UBQLN4 DYNC1LI1 TAL1 GSK3A VCP

1.19e-05182857int:PSMD8
InteractionHDAC1 interactions

YEATS2 IRS4 TRIM67 NFKB1 UBQLN4 HNRNPM USP24 SKOR1 SMARCC1 ZFHX3 IRS2 ANKHD1 TAL1 CIC GSK3A RING1

1.36e-0511088516int:HDAC1
InteractionZFHX4 interactions

SOX7 ZFHX3 EN1 CIC TLX1

1.42e-0573855int:ZFHX4
InteractionPPP2CB interactions

PABIR1 PACS1 TRIM67 SUPT5H ADARB1 CIC VCP TLX1

1.70e-05267858int:PPP2CB
InteractionPRPF40A interactions

ZC3H10 TRIM67 YBX1 UBQLN4 HNRNPM SMARCC1 ZFHX3 LTBP3 TAL1 GSK3A

1.81e-054468510int:PRPF40A
InteractionCTCF interactions

ZC3H10 TRIM67 YBX1 CDK19 HNRNPM EN1 TAL1 ADARB1 CIC RING1

2.40e-054618510int:CTCF
InteractionXRCC6 interactions

DNAJB1 ASXL1 TRIM67 SUPT5H HNRNPM DYNC1LI1 POU2F2 ZFHX3 KAT2A TAL1 ADARB1 CIC VCP TLX1

3.15e-059288514int:XRCC6
InteractionSFN interactions

PABIR1 MAGI1 DNAJB1 IRS4 TRIM67 HNRNPM IRS1 IRS2 GSK3A VCP RUSC2 ANKS1A

3.24e-056928512int:SFN
InteractionGSTM3 interactions

KCTD12 TRIM67 HNRNPM ANKHD1 HSPA2 ANKS1A

3.85e-05148856int:GSTM3
InteractionH2AX interactions

TRIM67 LZTS3 YBX1 SUPT5H SMARCC1 KAT2A ANKHD1 ADARB1 HSPA2 VCP RING1

3.87e-055938511int:H2AX
InteractionCHD7 interactions

SOX7 SUPT5H SMARCC1 EN1 CIC TLX1

4.15e-05150856int:CHD7
InteractionTLE4 interactions

TRIM67 YBX1 POU2F2 EN1 TLX1

4.37e-0592855int:TLE4
InteractionNFIX interactions

YBX1 BICRA SMARCC1 ZFHX3 KAT2A CIC RING1

4.91e-05227857int:NFIX
InteractionSATB2 interactions

SOX7 FOXD3 TRIM67 NFKB1 CIC TLX1

5.74e-05159856int:SATB2
InteractionYWHAE interactions

PABIR1 PACS1 IRS4 TRIM67 LRCH2 YBX1 DYNC1LI1 IRS1 IRS2 RGL2 SH3RF3 CIC GSK3A VCP RUSC2 ANKS1A

6.23e-0512568516int:YWHAE
InteractionSMARCA5 interactions

TRIM67 HNRNPM SMARCC1 KAT2A ADARB1 CIC GSK3A VCP RING1

6.31e-05415859int:SMARCA5
InteractionH2BC12 interactions

TOMM70 ASXL1 TRIM67 TRO ADARB1 CIC CNOT3 GSK3A

6.44e-05322858int:H2BC12
InteractionMTAP interactions

ASXL1 TRIM67 TRO DYNC1LI1 VCP

6.52e-05100855int:MTAP
InteractionRBM25 interactions

TRIM67 NFKB1 HNRNPM SMARCC1 TAL1 ADARB1 GSK3A VCP

6.58e-05323858int:RBM25
InteractionRUNX1 interactions

HNRNPM SMARCC1 TAL1 HSPA2 CIC CNOT3 GSK3A RING1

6.73e-05324858int:RUNX1
InteractionPELI2 interactions

PRR36 UBQLN4 IRS1 LTBP3

7.37e-0553854int:PELI2
InteractionOTULIN interactions

DNAJB1 TOMM70 IRS4 TRIM67 GSK3A VCP

8.05e-05169856int:OTULIN
InteractionTP53BP1 interactions

TRIM67 LRCH2 NFKB1 CDK19 SMARCC1 KAT2A ADARB1 CIC VCP ANKS1A

8.14e-055338510int:TP53BP1
InteractionYWHAB interactions

PABIR1 MAGI1 IRS4 TRIM67 DYNC1LI1 IRS1 IRS2 RGL2 SH3RF3 CIC GSK3A VCP RUSC2 ANKS1A

8.20e-0510148514int:YWHAB
InteractionPHF21A interactions

YEATS2 SOX7 IRS4 USP24 ZFHX3 IRS2 ANKHD1 CIC

1.00e-04343858int:PHF21A
InteractionEWSR1 interactions

KCTD12 DNAJB1 SOX7 TRIM67 YBX1 BICRA HNRNPM SMARCC1 EN2 HSPA2 CIC GSK3A VCP

1.03e-049068513int:EWSR1
InteractionARID1B interactions

SOX7 SUPT5H BICRA SMARCC1 HSPA2 TLX1

1.04e-04177856int:ARID1B
InteractionCNOT2 interactions

NFKB1 USP24 ZFHX3 ANKHD1 CNOT3 VCP

1.07e-04178856int:CNOT2
InteractionEIF3I interactions

KCTD12 TRIM67 YBX1 NFKB1 CIC CNOT3 VCP

1.10e-04258857int:EIF3I
InteractionH2BC18 interactions

ZC3H10 TRIM67 TRO SMARCC1 ADARB1 VCP

1.14e-04180856int:H2BC18
InteractionCAPZB interactions

IRS4 TRIM67 LRCH2 YBX1 NFKB1 UBQLN4 HNRNPM MARF1 SMARCC1 DYNC1LI1 SOWAHC CIC CNOT3 VCP

1.17e-0410498514int:CAPZB
InteractionSATB1 interactions

FOXD3 TRIM67 TAL1 CIC TLX1

1.32e-04116855int:SATB1
InteractionNOS2 interactions

TRIM67 YBX1 NFKB1 HSPA2 VCP RING1

1.36e-04186856int:NOS2
InteractionHIVEP1 interactions

ZC3H10 SUPT5H ZFHX3 EN1 TAL1 TLX1

1.36e-04186856int:HIVEP1
InteractionSMARCA4 interactions

SOX7 TRIM67 BICRA CDK19 USP24 SMARCC1 ADARB1 CIC VCP

1.43e-04462859int:SMARCA4
InteractionGLB1 interactions

DNAJB1 TRIM67 IRS1 TRAPPC14 VCP

1.43e-04118855int:GLB1
InteractionPIK3CA interactions

IRS4 TRIM67 NFKB1 IRS1 IRS2 CNOT3

1.44e-04188856int:PIK3CA
InteractionACTC1 interactions

YEATS2 IRS4 TRIM67 LRCH2 YBX1 BICRA HNRNPM SMARCC1 ADARB1 CIC VCP

1.57e-046948511int:ACTC1
InteractionDCAF7 interactions

TRIM67 LRCH2 LZTS3 SOWAHC CIC VCP TLX1 RING1

1.62e-04368858int:DCAF7
InteractionTNIP2 interactions

YEATS2 ASXL1 IRS4 LZTS3 YBX1 SUPT5H TRO NFKB1 HNRNPM SMARCC1 DYNC1LI1 EN2 VCP

1.69e-049528513int:TNIP2
InteractionPIK3R3 interactions

IRS4 IRS1 IRS2 VCP ANKS1A RING1

1.91e-04198856int:PIK3R3
InteractionGATA2 interactions

SMARCC1 ZFHX3 KAT2A TAL1 CIC RING1

1.97e-04199856int:GATA2
InteractionCCDC134 interactions

TRIM67 UBQLN4 VCP

1.97e-0427853int:CCDC134
InteractionPCBP2 interactions

ASXL1 TRIM67 YBX1 SKOR1 KAT2A CIC VCP

2.16e-04288857int:PCBP2
InteractionSMARCC1 interactions

SOX7 TRIM67 BICRA SMARCC1 ADARB1 CIC VCP TLX1

2.17e-04384858int:SMARCC1
InteractionHCFC1 interactions

YEATS2 ASXL1 TRIM67 YBX1 HNRNPM ADARB1 CIC

2.40e-04293857int:HCFC1
InteractionLRCH2 interactions

TRIM67 LRCH2 HSPA2 GSK3A

2.57e-0473854int:LRCH2
InteractionKMT2C interactions

SOX7 ASXL1 EN1 TLX1 RING1

2.58e-04134855int:KMT2C
InteractionAKT1 interactions

DNAJB1 ASXL1 MAP2K4 TRIM67 YBX1 SMARCC1 IRS1 KAT2A GSK3A VCP

2.67e-046178510int:AKT1
InteractionDENND4C interactions

MAGI1 TRIM67 HSPA2 SH3RF3 GSK3A

3.16e-04140855int:DENND4C
InteractionSMC3 interactions

TRIM67 SUPT5H HNRNPM EN1 NEURL4 CIC TLX1 RING1

3.26e-04408858int:SMC3
InteractionWDR37 interactions

YEATS2 PACS1 KAT2A HSPA2

3.31e-0478854int:WDR37
InteractionWIZ interactions

SOX7 TRIM67 EN1 HSPA2 CIC TLX1

3.37e-04220856int:WIZ
InteractionTRPS1 interactions

SOX7 ZFHX3 EN1 CIC TLX1

3.49e-04143855int:TRPS1
InteractionMIR143 interactions

ZC3H10 YBX1 HNRNPM ADARB1

3.65e-0480854int:MIR143
InteractionCYRIB interactions

TRIM67 CDK19 POU2F2 VCP

3.83e-0481854int:CYRIB
InteractionIRF2BP1 interactions

DNAJB1 CIC VCP TLX1

3.83e-0481854int:IRF2BP1
InteractionNCOA1 interactions

SOX7 NFKB1 SMARCC1 HSPA2 VCP

3.84e-04146855int:NCOA1
InteractionWBP2 interactions

MAGI1 TRIM67 DYNC1LI1 VCP

4.01e-0482854int:WBP2
InteractionRPS6KA1 interactions

MAGI1 TOB2 TRIM67 YBX1 GPR162 VCP

4.08e-04228856int:RPS6KA1
InteractionDDX3X interactions

TRIM67 YBX1 NFKB1 HNRNPM MARF1 ANKHD1 CIC CNOT3 GSK3A VCP

4.08e-046518510int:DDX3X
InteractionPIK3R2 interactions

IRS4 TRIM67 IRS1 IRS2 LTBP3 VCP

4.27e-04230856int:PIK3R2
CytobandEnsembl 112 genes in cytogenetic band chr19q13

SHANK1 RASIP1 CACNG8 SUPT5H BICRA POU2F2 LRRC4B CIC CNOT3 GSK3A

7.20e-0511928510chr19q13
Cytoband9p13.3

SPAG8 VCP RUSC2

3.76e-04758539p13.3
GeneFamilyNKL subclass homeoboxes and pseudogenes

NKX2-3 EN1 EN2 TLX1

7.67e-0567614519
GeneFamilyHOXL subclass homeoboxes

CDX4 HOXD9 GSX2

7.18e-0452613518
GeneFamilyATAC complex

YEATS2 KAT2A

8.53e-04136121058
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFHX2 ZFHX3

1.14e-0315612529
GeneFamilyAnkyrin repeat domain containing

SHANK1 NFKB1 ANKHD1 SOWAHC ANKS1A

1.33e-03242615403
GeneFamilyG protein-coupled receptors, Class A orphans

GPR135 LGR6 GPR162

2.32e-0378613262
CoexpressionBENPORATH_PRC2_TARGETS

SOX7 FOXD3 GJD2 TRIM67 LRCH2 HOXD9 NKX2-3 GSX2 ZFHX3 SLITRK3 EN1 EN2 TAL1 TLX1

2.17e-086508514M8448
CoexpressionBENPORATH_SUZ12_TARGETS

SOX7 FOXD3 CDX4 IRS4 GJD2 TRIM67 LRCH2 HOXD9 NKX2-3 GSX2 ZFHX3 SLITRK3 EN1 EN2 TAL1 TLX1

1.89e-0710358516M9898
CoexpressionBENPORATH_EED_TARGETS

SOX7 ASXL1 FOXD3 GJD2 TRIM67 LRCH2 HOXD9 HNRNPM NKX2-3 GSX2 ZFHX3 SLITRK3 EN1 EN2 TAL1 TLX1

2.58e-0710598516M7617
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

PACS1 CACNG8 TRIM67 LZTS3 GPR137C TMEM121B ZFHX2 POU2F2 LRRC4B ZFHX3 KIF3C GRM5 EN2 TAL1 RUSC2

2.45e-0611068515M39071
CoexpressionBENPORATH_ES_WITH_H3K27ME3

SOX7 FOXD3 CACNG8 GJD2 TRIM67 LRCH2 HOXD9 NKX2-3 GSX2 ZFHX3 SLITRK3 EN1 EN2 TAL1 TLX1

2.71e-0611158515M10371
CoexpressionTABULA_MURIS_SENIS_BRAIN_NON_MYELOID_NEURON_AGEING

YEATS2 PACS1 TRIM67 LZTS3 GPR137C FAM110D ZBTB22 ZFHX2 LRRC4B RGL2 GPR162 ANKS1A RING1

1.18e-059548513MM3689
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HDA2

PACS1 CACNG8 TRIM67 TMEM121B POU2F2 ZFHX3 GRM5 EN1 EN2

4.33e-05513859M39069
CoexpressionGSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN

MYOZ1 TMEM121B IRS2 EN1 SOWAHC RUSC2

4.85e-05200856M3781
CoexpressionGSE29164_DAY3_VS_DAY7_CD8_TCELL_TREATED_MELANOMA_UP

CACNG8 SUPT5H TRAPPC14 PEX11B RGL2 ANKS1A

4.85e-05200856M8488
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HSERT

MAP2K4 CACNG8 TRIM67 TMEM121B ZFHX2 POU2F2 ZFHX3 GRM5

1.08e-04450858M39072
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HDA1

TRIM67 TMEM121B ZFHX2 POU2F2 ZFHX3 KIF3C ZSWIM6 EN1 EN2

1.16e-04584859M39068
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

FOXD3 GJD2 PRR36 NKX2-3 SKOR1 GSX2 SLITRK3 TAL1 TLX1

1.27e-04591859M2019
CoexpressionMIKKELSEN_NPC_HCP_WITH_H3K27ME3

FOXD3 GJD2 HOXD9 NKX2-3 SKOR1 GSX2 TLX1

1.32e-04345857M2009
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBML5

TRIM67 LRCH2 GPR137C TMEM121B ZFHX2 POU2F2 ZFHX3 TAL1

1.35e-04465858M39066
CoexpressionMIKKELSEN_NPC_HCP_WITH_H3K27ME3

FOXD3 GJD2 HOXD9 NKX2-3 SKOR1 GSX2 TLX1

1.37e-04347857MM860
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

FOXD3 GJD2 PRR36 NKX2-3 SKOR1 GSX2 SLITRK3 TAL1 TLX1

1.44e-04601859MM866
CoexpressionTABULA_MURIS_SENIS_MARROW_MATURE_ALPHA_BETA_T_CELL_AGEING

TOB2 YBX1 BICRA UBQLN4 USP24 ZFHX2 ZSWIM6 CNOT3 GSK3A

1.65e-04612859MM3804
ToppCellmetastatic_Lymph_Node-Endothelial_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

MAGI1 RASIP1 LRCH2 HOXD9 FAM110D TAL1

1.15e-0617785671bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCellCOPD-Endothelial-VE_Capillary_B|World / Disease state, Lineage and Cell class

MAGI1 SOX7 RASIP1 FAM110D TAL1 SH3RF3

1.96e-0619485668705a6eca947c5b42b943d5224a7aef2a744007
ToppCellCOPD-Endothelial-VE_Capillary_B|COPD / Disease state, Lineage and Cell class

MAGI1 SOX7 RASIP1 FAM110D TAL1 SH3RF3

1.96e-0619485618b7f901c12ca4f21f9a1eafd092aefe4d668b6d
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM67 LRCH2 TRO GPR135 LTBP3 LGR6

2.02e-06195856d32716a12014522492becbde1088dc1106308490
ToppCelldroplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM67 LRCH2 TRO GPR135 LTBP3 LGR6

2.02e-06195856b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCellSubstantia_nigra|World / BrainAtlas - Mouse McCarroll V32

IRS4 ZFHX3 EN1 EN2 TAL1

2.79e-0611585518174b8d57d444fab1e9d2b13d22939c83c958e0
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SOX7 RASIP1 HOXD9 FAM110D TAL1

5.68e-06133855bc29a2faa151b0e48c1c7e3f016cccc49f9a15eb
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

SHANK1 TRIM67 FIGNL2 SKOR1 SH3RF3

9.87e-061498556e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCellVE-CD8-CD4_Treg|VE / Condition, Cell_class and T cell subcluster

SOX7 FIGNL2 KIF3C EXTL3 TMEM64

1.44e-05161855a114f4f75859d9ef900e5146686438d051241429
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI1 SOX7 RASIP1 FAM110D TAL1

2.09e-0517485540bb87d219aafab0357ab0d797efd38085fc0312
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI1 SOX7 RASIP1 FAM110D TAL1

2.45e-05180855455d1e3ccf2ab609954f3b870e8f514ddca735f4
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l19|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI1 SOX7 RASIP1 FAM110D TAL1

2.59e-05182855840427d1c23d60482c943ff006b14007ed44d247
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOB2 NFKB1 IRS2 SOWAHC ADARB1

2.80e-05185855eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SOX7 RASIP1 FAM110D RUSC2

2.95e-051878553548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SOX7 RASIP1 FAM110D RUSC2

2.95e-05187855f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SOX7 RASIP1 FAM110D RUSC2

2.95e-0518785581754e965848b718be20ee97ce072ce426938a69
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX7 RASIP1 FAM110D CDK19 RGL2

3.10e-05189855360f09f46231a83f99d8fa0158b72a38068e1642
ToppCellfacs-Thymus-Epithelium-3m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SOX7 RASIP1 FAM110D RUSC2

3.26e-051918556676ef9aeb890668cb69e67865404061b8467c25
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYOZ1 ZFHX3 ADARB1 HSPA2 TLX1

3.26e-05191855239c1e68eb1cbe3e137a99fbd6eeb8d64c919ffd
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM67 LRRC4B LTBP3 LGR6 SH3RF3

3.26e-051918559d3fa8d8138700640cc7927521c7635299df697d
ToppCellControl-Endothelial-VE_Venous|Control / Disease state, Lineage and Cell class

MAGI1 SOX7 RASIP1 FAM110D SH3RF3

3.26e-05191855617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCellfacs-Thymus-Epithelium-3m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SOX7 RASIP1 FAM110D RUSC2

3.26e-05191855a157cee0fbc9dce64308128c3578e7327fa178b7
ToppCellfacs-Thymus-Epithelium-3m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SOX7 RASIP1 FAM110D RUSC2

3.26e-05191855d2311a5b0cf186839000f9f272b6fbc2270ddb44
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM67 LRRC4B LTBP3 LGR6 SH3RF3

3.26e-05191855d04ed1e04b8cb904237d8e8388fe7740c724237b
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX7 RASIP1 HOXD9 FAM110D TAL1

3.34e-05192855945153c41dde6e90d103206955e1707b54eb0665
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCC1 LTBP3 KAT2A TAL1 ANKS1A

3.34e-0519285503dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX7 RASIP1 HOXD9 FAM110D TAL1

3.34e-051928556ab50579c63f31ca2cd41063a99b129f11c07510
ToppCellCOPD-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

MAGI1 RASIP1 LRCH2 HOXD9 TAL1

3.42e-0519385525bdc557055b5bce6a21f8696b48e991c696b979
ToppCellCOPD-Endothelial|COPD / Disease state, Lineage and Cell class

MAGI1 SOX7 RASIP1 TAL1 SH3RF3

3.42e-05193855093b28dcccb5841c995d0b33fae0efd6b88f97e0
ToppCellEndothelial-A-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

SOX7 RASIP1 FAM110D NKX2-3 TAL1

3.51e-05194855abea887dd472c1a0d572e690bc8914c1b94712ad
ToppCell3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCTD12 SOX7 RASIP1 FAM110D TAL1

3.60e-05195855527a5a50d6e2cbbbd64d11609e5cde2e33f14797
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX7 RASIP1 HOXD9 FAM110D TAL1

3.60e-051958554db30b3bc65c25626f828cd4f867f20c71809898
ToppCellfacs-GAT-Fat-3m-Endothelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SOX7 RASIP1 FAM110D TAL1

3.69e-05196855b6cc1f466d45479764080d34b1daeb8243a5a9f3
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCTD12 RASIP1 HOXD9 KIF3C TAL1

3.69e-0519685509a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCTD12 RASIP1 HOXD9 KIF3C TAL1

3.69e-05196855e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCellfacs-GAT-Fat-3m-Endothelial-endothelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SOX7 RASIP1 FAM110D TAL1

3.69e-05196855ede6104cdfa4ee5287efcca9bbc36677cbf7a8d8
ToppCellfacs-GAT-Fat-3m-Endothelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SOX7 RASIP1 FAM110D TAL1

3.69e-05196855039044ab28c53391c34d8226fb8cf78549e63ef4
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SOX7 RASIP1 FAM110D TAL1 SH3RF3

3.78e-05197855b0036cf3f7e6edf8e43f16cd2f0f0e80471d2576
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RASIP1 HOXD9 KIF3C TAL1 ANKS1A

3.78e-05197855407231542fa1ffd540dcb61435c0575e71f59725
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_2|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

CACNG8 POU2F2 ZFHX3 KIF3C ZSWIM6

3.87e-05198855b73b9feb82997b654718aa27f33ca7b454214802
ToppCell18-Airway-Endothelial-Endothelial|Airway / Age, Tissue, Lineage and Cell class

SOX7 RASIP1 HOXD9 FAM110D TAL1

3.87e-0519885570d3ea0837dd6ad62abdf349e566a2e62c8e345a
ToppCellILEUM-inflamed-(7)_CD36+_endothelial_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MAGI1 SOX7 RASIP1 FAM110D NKX2-3

3.87e-0519885505d6558c7990ad2277db999025a073d29b273dfc
ToppCellTracheal-NucSeq-Endothelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCTD12 RASIP1 HOXD9 FAM110D TAL1

3.87e-0519885577e31b6edeeb5ccd5cd3f080898c96bf9ab9f98d
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RASIP1 HOXD9 KIF3C TAL1 ANKS1A

3.87e-051988555d42f4fda2081ea3e9f62a00e7eea702e0d0be7d
ToppCelldistal-1-Endothelial-Bronchial_Vessel_1|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MAGI1 SOX7 RASIP1 HOXD9 FAM110D

3.87e-051988555cd81fe1a21c0e1a7f0d5a62ddf8e422b05aedc7
ToppCellILEUM-non-inflamed-(7)_ACKR1+_endothelial_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

KCTD12 MAGI1 SOX7 RASIP1 FAM110D

3.87e-05198855f8a6a75c9f2fbe32a22b14b6a029411c73c09f68
ToppCell18-Airway-Endothelial|Airway / Age, Tissue, Lineage and Cell class

SOX7 RASIP1 HOXD9 FAM110D TAL1

3.87e-051988556b7f1b352dc3a803af87106ffb63944bd4286dfe
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LZTS3 TRO USP24 SLITRK3 GRM5

3.96e-05199855333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LZTS3 TRO USP24 SLITRK3 GRM5

3.96e-05199855e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCTD12 SOX7 RASIP1 FAM110D NKX2-3

3.96e-05199855258d59cf811bf1668ffbb5f18f961021f660de62
ToppCellILEUM-non-inflamed-(7)_CD36+_endothelial_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MAGI1 SOX7 RASIP1 FAM110D NKX2-3

4.06e-0520085545755a597725015dc3ee36f9166f9e82f6f9c603
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MAGI1 SOX7 RASIP1 FAM110D NKX2-3

4.06e-05200855ec92fe4eafe527d351ee73c9735e96855ac506a3
ToppCell5'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCTD12 SOX7 RASIP1 FAM110D TAL1

4.06e-052008552554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial|GW12 / Sample Type, Dataset, Time_group, and Cell type.

UBQLN4 USP24 LRRC4B LTBP3 SH3RF3

4.06e-05200855be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-2|TCGA-Brain / Sample_Type by Project: Shred V9

TOMM70 GJD2 TRIM67 TLX1

1.03e-04127854018ffd9ff1913787cb0086a8581b399a121eaba1
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-4|TCGA-Cervix / Sample_Type by Project: Shred V9

PRR36 GPR137C ZFHX3 GPR162

1.06e-041288543ca9ae69fb8cb7f8acb7540aa71778bc917da4df
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_smooth_muscle-like|E16.5-samps / Age Group, Lineage, Cell class and subclass

GPR137C BICRA KAT2A SPAG8

1.19e-041328549633653dba1edee47d915212fb6e68426da49de5
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SOX7 RASIP1 FAM110D TAL1

2.15e-04154854b0735365de153d4586ca17896431d7bd9c7d8eac
ToppCellCOVID-19-kidney-Epithelial_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

RASIP1 GJD2 TAL1 SH3RF3

2.49e-041608540d4880f85565d8c540c94a8f8109147b3029279a
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

DNAJB1 ZBTB22 KIF3C GPR162

2.55e-0416185458381131e651744b5141b202f9d6063f55432db5
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KCTD12 RASIP1 HOXD9 FAM110D

2.68e-04163854c21114826bee1b05b411984326fef6b6e0d05316
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KCTD12 RASIP1 HOXD9 FAM110D

2.68e-041638545d49414432db259a19df50d7944581d00b69f537
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

LRRC4B IRS1 LTBP3 LGR6

2.74e-04164854e3983f655cdba308fb192182829f17bef99ce0ba
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK|Cerebellum / BrainAtlas - Mouse McCarroll V32

SOX7 RASIP1 FAM110D TAL1

2.80e-041658547d319a112b9062efee428bef6f4534d2ce782e04
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RASIP1 FAM110D TAL1 SH3RF3

2.87e-04166854f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellEndothelial-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

SOX7 RASIP1 LRCH2 TAL1

2.93e-041678546a03d16165e0b003092c39972928981abd4a75aa
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCTD12 RASIP1 HOXD9 GPR135

2.93e-04167854b93103a868fba63a8910bffb690a6242b9252833
ToppCellNS-critical-d_07-13-Myeloid-Mast_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TRO LRRC4B TAL1 ADARB1

2.93e-041678548a14fd980d8ebe8ef0216221f619d31aaa27ff15
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCTD12 RASIP1 HOXD9 GPR135

2.93e-04167854fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCTD12 RASIP1 HOXD9 GPR135

2.93e-04167854f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJD2 SKOR1 POU2F2 TLX1

2.93e-04167854691f3589de0f8c13f9137812cfa9040c07d237b4
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCTD12 RASIP1 HOXD9 GPR135

2.93e-0416785426cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

MAGI1 SOX7 RASIP1 FAM110D

3.07e-04169854605cc2638271803cf1d972ab3fa8f13f89666376
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

MAGI1 SOX7 RASIP1 FAM110D

3.07e-04169854337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122|Adult / Lineage, Cell type, age group and donor

RASIP1 FAM110D TAL1 SH3RF3

3.21e-04171854bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

YEATS2 GPR137C LRRC4B KIF3C

3.28e-0417285413d7117f92a92d77d6b4335ed800c585dc8b4511
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

YEATS2 GPR137C LRRC4B KIF3C

3.28e-041728543d83b2f03ad3af4dae3fe6cc0a0ef356872ca94f
ToppCellE12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX7 RASIP1 FAM110D TAL1

3.28e-04172854ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

YEATS2 GPR137C LRRC4B KIF3C

3.28e-04172854a3d431aed12c1192e8dca1dc85b8340fb7354f8d
ToppCellE12.5-Endothelial-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX7 RASIP1 FAM110D TAL1

3.28e-041728542136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

YEATS2 GPR137C LRRC4B KIF3C

3.28e-04172854028a5441242b2cc760cafc1822120180619c63ae
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

YEATS2 GPR137C LRRC4B KIF3C

3.28e-041728549fc70b1a143a8ec910336c23b761d908bb6aecb2
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RASIP1 TAL1 SH3RF3 ANKS1A

3.35e-04173854f193c63cc536d891c9d23043765e320252bb6e65
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 HOXD9 FAM110D TAL1

3.35e-04173854a2c1ef3f4d7e9f68fc77ee7c42a4727bdea5da94
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 HOXD9 FAM110D TAL1

3.35e-041738544830136f1f1976e00ac9af9062a531ac42533041
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 HOXD9 FAM110D TAL1

3.35e-041738540b79e2a4fd19d524c24b69a6b524ffc6affdabe5
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX7 RASIP1 FAM110D SOWAHC

3.35e-04173854fbc8ed566ea36c39c258dd6b3823c82f5d6eb17f
ToppCellmetastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs|metastatic_Lymph_Node / Location, Cell class and cell subclass

MAGI1 RASIP1 HOXD9 TAL1

3.43e-04174854d551bc29afef071adf4c9bb80345352ec33441d8
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 FOXD3 FAM110D TAL1

3.43e-04174854fa6eb451555766398996bbe8f555a3f4c0f3c108
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 FOXD3 FAM110D TAL1

3.43e-041748541f5b0fa58b2a7335667357af7e50e5242cd13d7d
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 FOXD3 FAM110D TAL1

3.43e-04174854ac3aee6ed49d1c421f33509e3ffc5cb17750a473
ToppCell368C-Endothelial_cells-Endothelial-D|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX7 RASIP1 FAM110D TAL1

3.50e-04175854c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRCH2 ZFHX3 LGR6 SH3RF3

3.50e-04175854316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCell368C-Endothelial_cells-Endothelial-D-|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX7 RASIP1 FAM110D TAL1

3.50e-04175854ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRCH2 ZFHX3 LGR6 SH3RF3

3.50e-04175854a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 TRO FAM110D TAL1

3.58e-04176854c4d9166e5bbb7ca544107db14e4374289f5de6bd
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX7 RASIP1 FAM110D CDK19

3.58e-0417685427e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX7 RASIP1 FAM110D CDK19

3.58e-04176854d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 TRO FAM110D TAL1

3.58e-04176854d58ef51002ea50b3037636038214bbb7454cb503
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX7 RASIP1 FAM110D TMEM64

3.74e-041788540139b42494c1186390b12106dea7957e2b6717c2
DrugBicuculline (+) [485-49-4]; Up 200; 10.8uM; HL60; HT_HG-U133A

GJD2 BICRA CDK19 POU2F2 EXTL3 SPAG8 ADARB1 RUSC2

8.01e-071998582139_UP
DrugLY 294002; Up 200; 10uM; MCF7; HT_HG-U133A

CDK19 MARF1 POU2F2 IRS2 TAL1 ADARB1 CNOT3

6.95e-061898575587_UP
DrugD-cycloserine [68-41-7]; Up 200; 39.2uM; MCF7; HT_HG-U133A

PACS1 LZTS3 IRS2 SPAG8 ADARB1 CIC RUSC2

8.81e-061968576782_UP
DrugMesoridazine besylate [32672-69-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A

KCTD12 PACS1 MYOZ1 KIF3C SPAG8 TRAPPC14 SOWAHC

9.41e-061988577017_UP
DrugIodipamide [606-17-7]; Up 200; 3.6uM; HL60; HT_HG-U133A

MAGI1 LZTS3 BICRA KIF3C KAT2A SPAG8 HSPA2

1.00e-052008573111_UP
Diseaseamnestic disorder (implicated_via_orthology)

IRS4 IRS1 IRS2

1.65e-069813DOID:10914 (implicated_via_orthology)
Diseaseobsolete aging

GJD2 TMEM121B NFKB1 SMARCC1 ZFHX3 LTBP3 GRM5

1.20e-05279817GO_0007568
Diseaseglucose metabolism disease (implicated_via_orthology)

IRS4 IRS1 IRS2

6.21e-0528813DOID:4194 (implicated_via_orthology)
Diseaseopportunistic bacterial infectious disease (implicated_via_orthology)

NFKB1 SMARCC1

2.65e-049812DOID:0050340 (implicated_via_orthology)
DiseaseBipolar Disorder

KCTD12 MAGI1 DNAJB1 PACS1 GRM5 ADARB1 GSK3A

3.43e-04477817C0005586
DiseaseAMYOTROPHIC LATERAL SCLEROSIS 1

UBQLN4 GSX2 KIF3C

3.56e-0450813C1862939
Diseasebody fat percentage

PACS1 MAN1A1 SKOR1 ZFHX3 IRS1 TAL1 ADARB1

3.93e-04488817EFO_0007800
Diseasealpha peak frequency measurement, alpha wave measurement, electroencephalogram measurement

PACS1 CDK19

4.03e-0411812EFO_0004357, EFO_0006870, EFO_0006883
DiseasePrecursor T-Cell Lymphoblastic Leukemia-Lymphoma

TAL1 CNOT3 TLX1

4.23e-0453813C1961099
Diseasefrontotemporal dementia (implicated_via_orthology)

UBQLN4 VCP

4.83e-0412812DOID:9255 (implicated_via_orthology)
DiseaseSchizophrenia

SHANK1 KCTD12 MAGI1 CACNG8 GRM5 EN1 EN2 ADARB1 GSK3A

7.03e-04883819C0036341
Diseaseintellectual disability (implicated_via_orthology)

IRS4 IRS1 IRS2

1.17e-0375813DOID:1059 (implicated_via_orthology)
Diseaselung non-small cell carcinoma (is_marker_for)

IRS4 NFKB1 ZFHX3 KAT2A

1.23e-03169814DOID:3908 (is_marker_for)
DiseaseAttention Deficit Disorder

GRM5 CIC

1.66e-0322812C0041671
DiseaseMinimal Brain Dysfunction

GRM5 CIC

1.66e-0322812C1321905
Diseaseosteoporosis (biomarker_via_orthology)

IRS1 IRS2

1.66e-0322812DOID:11476 (biomarker_via_orthology)
DiseaseAttention deficit hyperactivity disorder

GRM5 CIC

1.98e-0324812C1263846
Diseasesensory perception of bitter taste

DYNC1LI1 SH3RF3

2.32e-0326812GO_0050913
Diseasealcohol use disorder measurement, alcohol consumption measurement

RASIP1 TOB2 ZFHX3

2.44e-0397813EFO_0007878, EFO_0009458
DiseaseTYPE 2 DIABETES MELLITUS

IRS1 IRS2

2.69e-0328812125853
DiseaseType 2 diabetes mellitus

IRS1 IRS2

2.69e-0328812cv:C0011860

Protein segments in the cluster

PeptideGeneStartEntry
PGGDGTAGTGGTGGG

CDX4

21

O14627
NGTAGGAGAGVGGTG

CDK19

406

Q9BWU1
PESIGGPGGTGGGGS

GJD2

121

Q9UKL4
GSGGGGGGLGSSSHP

ANKS1A

46

Q92625
GLKGSGPSGGSGGGA

DNAJB1

71

P25685
AATTAIGGGGGPGGG

ASXL1

636

Q8IXJ9
PSVQPSGGGGGGSGG

CNOT3

391

O75175
MAAPSPSGGGGSGGG

MAP2K4

1

P45985
GSGGGSGSGTPGPVG

MAP2K4

11

P45985
TGSSGAGGPGTPGGA

RASIP1

101

Q5U651
GPGTGSGAPAGSGGK

RASIP1

301

Q5U651
GSTGTGGPGVGSGGA

KAT2A

56

Q92830
GAGGSAGGVGATGGA

GRM5

966

P41594
GGGSQGSFPGPRGSG

LZTS3

61

O60299
TSGIGSGGGGGSGVV

MAGI1

976

Q96QZ7
GGGGTKAGGPGALGT

GPR162

221

Q16538
EGSTPAGGGLSGGGG

LGR6

941

Q9HBX8
AGREPSTPGGGSGGG

GPR137C

16

Q8N3F9
STPGGGSGGGGAVAA

GPR137C

21

Q8N3F9
IAKQGGGGGGGSVPG

HNRNPM

386

P52272
GGSPAGGAGGGSSGL

DYNC1LI1

466

Q9Y6G9
AGGAATPSSGGGGGG

KIF3C

261

O14782
GGAGAGVTGAGGSGV

GSX2

81

Q9BZM3
GSGGGGSGASGGPTI

HSPA2

621

P54652
HPSRTAGGGGGGGGA

POU2F2

411

P09086
TGGTGPGAGIGAATG

HOXD9

221

P28356
TGGSPAEGGGSGGGG

PABIR1

16

Q96E09
TVPFGAGAAVGGGGG

IRS1

1116

P35568
GEGSQLSNGGGGGPG

ADARB1

36

P78563
SDTGGGGSGGGAGSP

EN1

221

Q05925
GGSGGGAGSPGAQGT

EN1

226

Q05925
PGGAGGGSGQRGSGV

PACS1

11

Q6VY07
AVGVGSTGGGCGGPG

IRS2

1296

Q9Y4H2
GGGAGGSGGSGPSAI

CACNG8

246

Q8WXS5
GGTAAAPGGGGLGGS

GPR135

61

Q8IZ08
PGGSASGPGGTGGGK

GSK3A

36

P49840
SGPGGTGGGKASVGA

GSK3A

41

P49840
MGGGVGASSSGGGPG

GSK3A

56

P49840
GSGTGFRPIGGGAGG

EXTL3

631

O43909
QVPAGGAGGGTGGSG

LTBP3

141

Q9NS15
GAGGGTGGSGPGLSR

LTBP3

146

Q9NS15
TSPMRFGGGGGGSGG

MARF1

111

Q9Y4F3
SSPAGGVLGGGLGGG

MAN1A1

11

P33908
PGTKSGGGGGSGALG

FIGNL2

116

A6NMB9
GGGGGSGALGGSPVL

FIGNL2

121

A6NMB9
PESSPGGGSGGGGGS

EN2

21

P19622
ILGSPATGGGGGGSG

BICRA

81

Q9NZM4
ATGGGGGGSGGADQP

BICRA

86

Q9NZM4
GGGVPGGSETGGLGG

PEX11B

161

O96011
GGSETGGLGGPGTPG

PEX11B

166

O96011
STRGLPNGGGGGGGS

KCTD12

6

Q96CX2
PAGGGGGGGGTSAAT

NKX2-3

296

Q8TAU0
MAAGSGGSGGSGGGP

NEURL4

1

Q96JN8
GGGGPSGSGSGPGSN

NEURL4

21

Q96JN8
SSVGTGGGGTGGVGG

RING1

211

Q06587
SGGGPGAGSGSAGGL

FOXD3

116

Q9UJU5
PGGSAVGAGVAGGTG

FOXD3

391

Q9UJU5
VDPVAAGGTGSGGGG

LRRC4B

456

Q9NT99
PGGSGGVGGGSGGYT

LRRC4B

471

Q9NT99
GGGGGGGGGTLVVPI

LRCH2

36

Q5VUJ6
GTAGGHGSGGGQRPG

IRS4

551

O14654
GPASAGAAGGTGGGG

GAREM2

191

Q75VX8
GGPGGSGSGGGASDT

RUSC2

206

Q8N2Y8
GAGTGGGAGGPGASH

SKOR1

431

P84550
ASGGTGYGGEGSGPG

RGL2

631

O15211
GPAGGGGGGTPSSVD

SOX7

181

Q9BT81
GSGSGSGPGCGSVPG

SPAG8

156

Q99932
VGGPGSRSAGGAGGT

TMEM121B

146

Q9BXQ6
TGKDPVVGAGGGGGG

TAL1

256

P17542
GSGGGPGGAEGGGVT

PRR36

1276

Q9H6K5
PAVGGVSGVVGGTGG

SLITRK3

841

O94933
SPGSSSGGGRGRGGG

SOWAHC

226

Q53LP3
SAGGQRGGFGSPGGG

SUPT5H

676

O00267
RGGFGSPGGGSGGMS

SUPT5H

681

O00267
GGGGPGTAVGATGSG

SMARCC1

6

Q92922
RGVDSPGGAGGGGGS

FAM110D

216

Q8TAY7
GTPREGPAGGTGGSG

SHANK1

521

Q9Y566
TGGSGGPGGSLGSRG

SHANK1

531

Q9Y566
GPASGVGSSGGGGSG

ANKHD1

51

Q8IWZ3
PGGGTTAGSGAGAGS

CIC

786

Q96RK0
GALAGGPGSGGGGVV

TMEM64

86

Q6YI46
GPTGTAQGAPSGGGG

TRIM67

266

Q6ZTA4
KPGTTGSGAGSGGPG

YBX1

26

P67809
AGGTSGGPGGGTGVP

ZFHX2

2046

Q9C0A1
GGLGTSAGFGGGPGT

TRO

1241

Q12816
SAGFGGGPGTSTGFG

TRO

1246

Q12816
GGPGTSTGFGGGLGT

TRO

1251

Q12816
FSGGPSTGAGFGGGP

TRO

1386

Q12816
AGPSQGSGGGTGGSV

VCP

781

P55072
AGSGTGGGPGLGSRG

TRAPPC14

56

Q8WVR3
GGGGGAAGSTPGSPV

SH3RF3

151

Q8TEJ3
VPSSGSGVGGGGTAG

TOMM70

16

O94826
SGVGGGGTAGPGTGG

TOMM70

21

O94826
TGAGGAGAYGTGGPG

TLX1

66

P31314
GAGGGGGGGSSSSPA

ZSWIM6

146

Q9HCJ5
GDGGGGGPSRGGSTG

USP24

76

Q9UPU5
GGPSRGGSTGGGGGF

USP24

81

Q9UPU5
TGSSGGGPGGGGSEE

ZC3H10

11

Q96K80
QAPGSGGEGTGGSGT

UBQLN4

341

Q9NRR5
DGQGSGTPGPFGGSG

TOB2

276

Q14106
VPGSVGGVPGGTGSG

ZBTB22

466

O15209
GGGTAGGGTQSTAGP

YEATS2

826

Q9ULM3
TQGGGACGSGSGSGP

ZFHX3

151

Q15911
VLHVPTGGGGGGSGG

ZFHX3

3501

Q15911
GSGSGAGGTGGPAGQ

MYOZ1

136

Q9NP98
GGGGGGTGSTGPGYS

NFKB1

391

P19838