Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 PTGER2 GPR32P1 OR6C2 S1PR1 OR6C4 S1PR3 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	7.35e-23	884	36	23	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	9.24e-23	431	36	19	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 PTGER2 GPR32P1 OR6C2 S1PR1 OR6C4 S1PR3 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	1.06e-18	1353	36	23	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR8I2 OR6K3 OR5K2 OR5M3 OR5K1	3.09e-06	127	36	5	GO:0005549
GeneOntologyMolecularFunction	sphingosine-1-phosphate receptor activity	S1PR1 S1PR3	8.79e-05	8	36	2	GO:0038036
GeneOntologyMolecularFunction	bioactive lipid receptor activity	S1PR1 S1PR3	3.73e-04	16	36	2	GO:0045125
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	5.27e-23	432	36	19	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	2.14e-22	465	36	19	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	4.76e-22	485	36	19	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	2.06e-21	524	36	19	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	4.64e-21	547	36	19	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	1.49e-20	582	36	19	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 PKD1L1 OR52E8 OR6J1	2.55e-20	722	36	20	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 PTGER2 GPR32P1 OR6C2 S1PR1 OR6C4 S1PR3 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	1.03e-18	1395	36	23	GO:0007186
GeneOntologyBiologicalProcess	sensory perception	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	1.26e-15	1072	36	19	GO:0007600
GeneOntologyBiologicalProcess	sphingosine-1-phosphate receptor signaling pathway	S1PR1 S1PR3	3.07e-04	15	36	2	GO:0003376
GeneOntologyBiologicalProcess	sphingolipid mediated signaling pathway	S1PR1 S1PR3	4.45e-04	18	36	2	GO:0090520
Domain	7tm_1	OR6C3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 PTGER2 OR6C2 S1PR1 OR6C4 S1PR3 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	9.68e-23	677	33	21	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR6C3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 PTGER2 OR6C2 S1PR1 OR6C4 S1PR3 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	1.24e-22	685	33	21	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR6C3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 PTGER2 OR6C2 S1PR1 OR6C4 S1PR3 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	1.48e-22	691	33	21	PS50262
Domain	GPCR_Rhodpsn	OR6C3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 PTGER2 OR6C2 S1PR1 OR6C4 S1PR3 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	1.53e-22	692	33	21	IPR000276
Domain	Olfact_rcpt	OR6C3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	3.45e-22	393	33	18	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR6C3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 PTGER2 OR6C2 S1PR1 OR6C4 S1PR3 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8	3.49e-21	670	33	20	IPR017452
Domain	EDG1_rcpt	S1PR1 S1PR3	3.03e-06	2	33	2	IPR000987
Domain	S1P_rcpt	S1PR1 S1PR3	3.02e-05	5	33	2	IPR004061
Domain	7TM_GPCR_Srsx	OR6F1 OR56B1 S1PR1 S1PR3	4.38e-05	112	33	4	SM01381
Domain	AA_permease_2	SLC7A3 SLC7A13	2.33e-04	13	33	2	PF13520
Domain	AA/rel_permease1	SLC7A3 SLC7A13	2.33e-04	13	33	2	IPR002293
Domain	AA-permease/SLC12A_dom	SLC7A3 SLC7A13	6.84e-04	22	33	2	IPR004841
Domain	AA_permease	SLC7A3 SLC7A13	6.84e-04	22	33	2	PF00324
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	9.06e-23	417	29	19	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR6C3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8	8.46e-20	389	29	17	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8 OR6J1	2.73e-19	636	29	19	M41834
Pathway	WP_GPCRS_SMALL_LIGAND	PTGER2 S1PR1 S1PR3	6.26e-06	18	29	3	MM15858
Pathway	WP_SMALL_LIGAND_GPCRS	PTGER2 S1PR1 S1PR3	7.42e-06	19	29	3	M39728
Pathway	REACTOME_LYSOSPHINGOLIPID_AND_LPA_RECEPTORS	S1PR1 S1PR3	3.66e-04	14	29	2	M27331
Pathway	WP_MODULATION_OF_PI3KAKTMTOR_SIGNALING_BY_BIOACTIVE_SPHINGOLIPIDS	S1PR1 S1PR3	3.66e-04	14	29	2	M45553
Pathway	REACTOME_LYSOSPHINGOLIPID_AND_LPA_RECEPTORS	S1PR1 S1PR3	3.66e-04	14	29	2	MM15062
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR6F1 OR5K2 OR5K1	3.91e-04	70	29	3	MM14984
Pathway	PID_S1P_META_PATHWAY	S1PR1 S1PR3	8.38e-04	21	29	2	M155
Pathway	WP_GPCRS_OTHER	OR6C3 OR6C2 S1PR1	8.97e-04	93	29	3	M39629
Pathway	WP_SIGNAL_TRANSDUCTION_OF_S1P_RECEPTOR	S1PR1 S1PR3	1.01e-03	23	29	2	MM15952
Pathway	WP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION	S1PR1 S1PR3	1.19e-03	25	29	2	M39384
Pathway	PID_S1P_S1P3_PATHWAY	S1PR1 S1PR3	1.60e-03	29	29	2	M55
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8	2.99e-23	340	36	16	11802173
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8	2.99e-23	340	36	16	11875048
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8	3.45e-23	343	36	16	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR6C3 OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR6C68 OR5M3 OR56B1 OR5K1 OR6C2 OR6C70 OR6C76 OR6C1 OR9A2 OR52E8	3.97e-23	346	36	16	14611657
Pubmed	Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.	OR6C3 OR6C68 OR6C2 OR6C4 OR6C70 OR6C76 OR6C1	2.34e-16	24	36	7	24152035
Pubmed	The human olfactory receptor gene family.	OR10D3 OR6F1 OR8I2 OR6K3 OR5K2 OR5M3 OR56B1 OR5K1 OR6C4 OR6M1 OR9A2 OR52E8	1.59e-13	541	36	12	14983052
Pubmed	Natural selection on the olfactory receptor gene family in humans and chimpanzees.	OR6F1 OR6M1 OR9A2	6.86e-07	17	36	3	12908129
Pubmed	Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation.	S1PR1 S1PR3	1.04e-06	2	36	2	29066950
Pubmed	S1P1 and S1P3 are potential markers of cardiac microangiopathy in diabetes.	S1PR1 S1PR3	1.04e-06	2	36	2	22595806
Pubmed	Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor.	S1PR1 S1PR3	1.04e-06	2	36	2	23392686
Pubmed	Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes.	S1PR1 S1PR3	1.04e-06	2	36	2	21289599
Pubmed	Effects of S1P1 and S1P3 in ER+ and ER- Breast Cancer Cells.	S1PR1 S1PR3	1.04e-06	2	36	2	28982858
Pubmed	Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease.	S1PR1 S1PR3	1.04e-06	2	36	2	25330249
Pubmed	Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.	S1PR1 S1PR3	1.04e-06	2	36	2	9409733
Pubmed	Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.	S1PR1 S1PR3	1.04e-06	2	36	2	10555146
Pubmed	The origin and maturity of dendritic cells determine the pattern of sphingosine 1-phosphate receptors expressed and required for efficient migration.	S1PR1 S1PR3	1.04e-06	2	36	2	20826749
Pubmed	Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction.	S1PR1 S1PR3	1.04e-06	2	36	2	26494861
Pubmed	Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth.	S1PR1 S1PR3	1.04e-06	2	36	2	20874260
Pubmed	Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo.	S1PR1 S1PR3	1.04e-06	2	36	2	25954148
Pubmed	Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor.	S1PR1 S1PR3	1.04e-06	2	36	2	16960101
Pubmed	Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3.	S1PR1 S1PR3	1.04e-06	2	36	2	17331465
Pubmed	Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions.	S1PR1 S1PR3	1.04e-06	2	36	2	20648639
Pubmed	S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure.	S1PR1 S1PR3	1.04e-06	2	36	2	28607130
Pubmed	Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation.	S1PR1 S1PR3	1.04e-06	2	36	2	21660960
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR6F1 OR8I2 OR5M3 OR6M1 OR6C1	3.04e-06	219	36	5	12213199
Pubmed	Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.	S1PR1 S1PR3	3.12e-06	3	36	2	15184895
Pubmed	Differential expression of S1P receptor subtypes in human bladder transitional cell carcinoma.	S1PR1 S1PR3	3.12e-06	3	36	2	30712233
Pubmed	Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation.	PTGER2 S1PR3	3.12e-06	3	36	2	27616330
Pubmed	Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility.	S1PR1 S1PR3	3.12e-06	3	36	2	21145832
Pubmed	Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis.	S1PR1 S1PR3	3.12e-06	3	36	2	23466305
Pubmed	Role of sphingosine kinase and sphingosine-1-phosphate receptor in the liver pathology of mice infected with Plasmodium berghei ANKA.	S1PR1 S1PR3	3.12e-06	3	36	2	35333897
Pubmed	S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses.	S1PR1 S1PR3	3.12e-06	3	36	2	18296752
Pubmed	Differential expression of sphingosine-1-phosphate receptors in abdominal aortic aneurysms.	S1PR1 S1PR3	3.12e-06	3	36	2	22547907
Pubmed	Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells.	S1PR1 S1PR3	3.12e-06	3	36	2	22889737
Pubmed	Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung.	S1PR1 S1PR3	3.12e-06	3	36	2	19749179
Pubmed	HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium.	S1PR1 S1PR3	3.12e-06	3	36	2	28179022
Pubmed	Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.	S1PR1 S1PR3	3.12e-06	3	36	2	10383399
Pubmed	[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors].	S1PR1 S1PR3	3.12e-06	3	36	2	11915348
Pubmed	S1P1 receptor directs the release of immature B cells from bone marrow into blood.	S1PR1 S1PR3	3.12e-06	3	36	2	20404103
Pubmed	Regulation of endothelial nitric oxide synthase activation in endothelial cells by S1P1 and S1P3.	S1PR1 S1PR3	3.12e-06	3	36	2	27282481
Pubmed	Interaction of integrin β4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancement.	S1PR1 S1PR3	6.24e-06	4	36	2	24851274
Pubmed	Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha.	S1PR1 S1PR3	6.24e-06	4	36	2	18658144
Pubmed	Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy.	S1PR1 S1PR3	6.24e-06	4	36	2	31988136
Pubmed	Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.	S1PR1 S1PR3	6.24e-06	4	36	2	10818441
Pubmed	Sphingosine-1-phosphate receptor expression and signaling correlate with uterine prostaglandin-endoperoxide synthase 2 expression and angiogenesis during early pregnancy.	S1PR1 S1PR3	6.24e-06	4	36	2	16319286
Pubmed	Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.	S1PR1 S1PR3	6.24e-06	4	36	2	12006579
Pubmed	Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity.	S1PR1 S1PR3	6.24e-06	4	36	2	19633297
Pubmed	Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate.	S1PR1 S1PR3	6.24e-06	4	36	2	9931453
Pubmed	Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors.	S1PR1 S1PR3	6.24e-06	4	36	2	22178384
Pubmed	Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.	S1PR1 S1PR3	1.04e-05	5	36	2	25333900
Pubmed	Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.	S1PR1 S1PR3	1.04e-05	5	36	2	16980623
Pubmed	Sphingosine 1-Phoshpate Receptors are Located in Synapses and Control Spontaneous Activity of Mouse Neurons in Culture.	S1PR1 S1PR3	1.04e-05	5	36	2	35781853
Pubmed	Sphingosine-1-phosphate receptor 2.	S1PR1 S1PR3	1.04e-05	5	36	2	23879641
Pubmed	High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.	S1PR1 S1PR3	1.04e-05	5	36	2	20889557
Pubmed	Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell.	S1PR1 S1PR3	1.04e-05	5	36	2	24038457
Pubmed	The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis.	S1PR1 S1PR3	1.04e-05	5	36	2	15138255
Pubmed	Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin.	S1PR1 S1PR3	1.04e-05	5	36	2	25832730
Pubmed	Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.	S1PR1 S1PR3	1.04e-05	5	36	2	27582371
Pubmed	Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.	S1PR1 S1PR3	1.04e-05	5	36	2	18424450
Pubmed	Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.	S1PR1 S1PR3	1.56e-05	6	36	2	10488065
Pubmed	Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3.	S1PR1 S1PR3	1.56e-05	6	36	2	11443127
Pubmed	Follicular shuttling of marginal zone B cells facilitates antigen transport.	S1PR1 S1PR3	1.56e-05	6	36	2	18037889
Pubmed	ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex.	S1PR1 S1PR3	1.56e-05	6	36	2	26903652
Pubmed	The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.	S1PR1 S1PR3	1.56e-05	6	36	2	24903384
Pubmed	Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages.	S1PR1 S1PR3	2.18e-05	7	36	2	30655318
Pubmed	Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.	S1PR1 S1PR3	2.18e-05	7	36	2	20407207
Pubmed	Essential role for sphingosine kinases in neural and vascular development.	S1PR1 S1PR3	2.18e-05	7	36	2	16314531
Pubmed	The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development.	S1PR1 S1PR3	2.18e-05	7	36	2	21668976
Pubmed	Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system.	S1PR1 S1PR3	2.18e-05	7	36	2	19161225
Pubmed	Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.	S1PR1 S1PR3	2.91e-05	8	36	2	11854302
Pubmed	Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme.	S1PR1 S1PR3	4.66e-05	10	36	2	15689381
Pubmed	Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development.	S1PR1 S1PR3	4.66e-05	10	36	2	16434032
Pubmed	Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis.	S1PR1 S1PR3	4.66e-05	10	36	2	12401212
Pubmed	The finished DNA sequence of human chromosome 12.	OR6C3 OR6C2 OR6C1	5.09e-05	69	36	3	16541075
Pubmed	Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney.	S1PR1 S1PR3	5.70e-05	11	36	2	19073640
Pubmed	Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells.	S1PR1 S1PR3	5.70e-05	11	36	2	20458606
Pubmed	Expression patterns of the lysophospholipid receptor genes during mouse early development.	S1PR1 S1PR3	8.07e-05	13	36	2	18924241
Pubmed	Lysophospholipid receptor nomenclature review: IUPHAR Review 8.	S1PR1 S1PR3	1.08e-04	15	36	2	24602016
Pubmed	Growth-limiting role of endothelial cells in endoderm development.	S1PR1 S1PR3	2.38e-04	22	36	2	21281624
Pubmed	The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.	OR6C3 OR6C2	2.60e-04	23	36	2	10706615
Pubmed	Expression of members of the putative olfactory receptor gene family in mammalian germ cells.	OR10D3 OR5K1	3.08e-04	25	36	2	1370859
Pubmed	Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.	S1PR1 S1PR3	7.93e-04	40	36	2	21319224
Cytoband	12q13.2	OR6C3 OR6C68 OR6C2 OR6C4 OR6C70 OR6C76 OR6C1	1.94e-14	55	36	7	12q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	OR6C3 OR6C68 OR6C2 OR6C4 OR6C70 OR6C76 OR6C1 NCKAP1L	1.17e-09	423	36	8	chr12q13
Cytoband	3q11.2	OR5K2 OR5K1	1.92e-04	26	36	2	3q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr11q24	OR10D3 HEPACAM OR6M1	4.57e-04	191	36	3	chr11q24
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5K2 OR5K1	8.34e-04	54	36	2	chr3q11
Cytoband	11q24.2	OR10D3 HEPACAM	1.13e-03	63	36	2	11q24.2
Cytoband	11q12.1	OR8I2 OR5M3	7.12e-03	161	36	2	11q12.1
Cytoband	11p15.4	OR56B1 OR52E8	1.08e-02	200	36	2	11p15.4
GeneFamily	Olfactory receptors, family 6	OR6C3 OR6F1 OR6K3 OR6C68 OR6C2 OR6C4 OR6M1 OR6C70 OR6C76 OR6C1 OR6J1	1.49e-21	51	30	11	153
GeneFamily	Sphingosine 1-phosphate receptors\|CD molecules	S1PR1 S1PR3	2.65e-05	5	30	2	206
GeneFamily	Olfactory receptors, family 5	OR5K2 OR5M3 OR5K1	8.32e-04	112	30	3	152
Drug	3,5-diphenyl-1,2,4-oxadiazole	S1PR1 S1PR3	6.49e-06	3	34	2	CID000136695
Drug	3,5,5-trimethylhexanoylferrocene	GBE1 GCLC HSD17B13	3.12e-05	41	34	3	ctd:C050224
Disease	Alzheimer disease, APOE carrier status	OR5K2 OR5K1	4.47e-03	98	30	2	EFO_0007659, MONDO_0004975

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLYTAISLVYRLLLT	BEST3	41	Q8N1M1
ILSVVLVLIYLYLTP	AMIGO1	381	Q86WK6
EILLLLITIIYSYLE	HSD17B13	6	Q7Z5P4
IGSVLISYLYILLTI	OR5K2	211	Q8NHB8
LIFLSYIYIIRTILR	OR6C1	211	Q96RD1
YIYIIRTILRIPSTS	OR6C1	216	Q96RD1
IITLVCVILSYLYIV	OR6C2	206	Q9NZP2
CVILSYLYIVRTILK	OR6C2	211	Q9NZP2
IVTLFLVILSYSYII	OR6C70	206	A6NIJ9
LLSSLLIITVTYIII	OR8I2	206	Q8N0Y5
TIIITFLIIALSYVR	OR6K3	221	Q8NGY3
YLQLYATLLLLLIVS	PTGER2	196	P43116
YVVFVVLLTRVILSY	GCLC	441	P48506
SLIILSYILILYSVL	OR56B1	221	Q8NGI3
YLDLIVTYTSVILLL	NCKAP1L	131	P55160
TYSLTVIIISYLFIL	OR5M3	206	Q8NGP4
IRISLFVVLVVTYTL	OR6M1	21	Q8NGM8
LVTLSYTYIIRTILR	OR6C4	211	Q8NGE1
STLILVILSYTYIIR	OR6C76	206	A6NM76
VILSYTYIIRTILRI	OR6C76	211	A6NM76
IGSVLISYLYILLTI	OR5K1	211	Q8NHB7
YSEITLYLIIALSTV	PCDHAC2	701	Q9Y5I4
LTIIILSIIKCYRYT	PCDHAC2	721	Q9Y5I4
YSLLVYIPSRVALIL	GBE1	681	Q04446
LSLSLPILVYYIVSR	GPR32P1	91	Q8NGA4
IYTIIYILSVLLRIS	GJE1	111	A6NN92
VKITVYRRSSLYIIL	HEPACAM	231	Q14CZ8
TLLLLSIVILYCRIY	S1PR1	211	P21453
AILVTIVILYARIYF	S1PR3	206	Q99500
YTEIRNYITVITRIL	PKD1L1	1316	Q8TDX9
VLSEYLIPIVVRYLT	PPP4R1L	126	Q9P1A2
LAYSLVSICVLILRY	SLC7A3	416	Q8WY07
FLLILLSYTRITISI	OR10D3	211	Q8NH80
IVSYTYIISTILKIP	OR9A2	211	Q8NGT5
VSYVYIISTILRIPS	OR6F1	216	Q8NGZ6
VILIILSYVRILYAV	OR52E8	216	Q6IFG1
CVVLSYTYIIRTILK	OR6C68	211	A6NDL8
SYTYIILTIVRIPSA	OR6J1	216	Q8NGC5
VILSYMYIIRTILRI	OR6C3	211	Q9NZP0
VVYLLVNISYLTVLT	SLC7A13	251	Q8TCU3