Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionleukemia inhibitory factor receptor activity

LIFR IL6ST

1.18e-0422172GO:0004923
GeneOntologyMolecularFunctionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

IDO1 ALOX12B BCO1 ALOXE3

1.43e-04252174GO:0016702
GeneOntologyMolecularFunctionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen

IDO1 ALOX12B BCO1 ALOXE3

1.68e-04262174GO:0016701
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXND1 PLXNA2 PLXNA3

2.59e-04122173GO:0017154
GeneOntologyMolecularFunctiononcostatin-M receptor activity

LIFR IL6ST

3.50e-0432172GO:0004924
GeneOntologyCellularComponentlysosomal membrane

SLC29A3 MANBA HLA-DRB3 B2M WDR81 ATP10B TSC2 SURF4 GLIPR1 NSF TLR9 ABCB9 MTOR SLC15A4 VPS13B

1.15e-0446221915GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

SLC29A3 MANBA HLA-DRB3 B2M WDR81 ATP10B TSC2 SURF4 GLIPR1 NSF TLR9 ABCB9 MTOR SLC15A4 VPS13B

1.15e-0446221915GO:0098852
GeneOntologyCellularComponentsemaphorin receptor complex

PLXND1 PLXNA2 PLXNA3

3.00e-04132193GO:0002116
GeneOntologyCellularComponentvacuolar membrane

SLC29A3 MANBA HLA-DRB3 B2M WDR81 ATP10B TSC2 SURF4 GLIPR1 NSF TLR9 ABCB9 MTOR SLC15A4 VPS13B

3.12e-0450721915GO:0005774
DomainPlexin_cytopl

PLXND1 PLXNA2 PLXNA3

1.09e-0492083PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXND1 PLXNA2 PLXNA3

1.09e-0492083IPR013548
DomainPlexin

PLXND1 PLXNA2 PLXNA3

1.09e-0492083IPR031148
DomainGamma_tubulin

TUBG2 TUBG1

1.23e-0422082IPR002454
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

SLC29A3 USP9X B2M PLXND1 FAT1 PTPRJ SURF4 SEC16A EXOG NSF WWP2 DOLK TMEM177 ABHD5 TMEM168 TMTC4 SLC15A4 FANCI UBE3C ARHGEF2 PRAF2 PCDH9 CSGALNACT1 IL6ST

8.09e-0810612202433845483
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

TBRG4 CAND1 NUP85 USP9X B2M TSC2 TUBG1 SURF4 ADAMTS1 NSF GRAMD1A NUP88 FAF1 SPAG5 AAAS LRIG1 MTOR FANCI TCF25 ATP1A1 ARHGEF2 PRAF2

1.69e-079422202231073040
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

MANBA NUP85 TUBG2 EIF3E PSMD3 COPS2 TUBG1 HEPH FBXL5 PTPRJ UCK2 GEMIN5 LIFR SUSD1 TMEM131 ATP1A1 ARHGEF2

4.45e-076132201722268729
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

HBS1L PRR5L CYP27B1 COPS2 RNF215 SGMS1 PGAP1 SEC16A CPLANE1 NMT1 BAIAP3 AEN NRDC FAM210A GEMIN5 SPAG5 TMEFF1 PRKAA1 TMEM131 LPAR2 KIF13A VPS13B NCKAP1L

4.68e-0710842202311544199
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CPNE8 TBRG4 CAND1 NUP85 MTHFD2 B2M EIF3E PSMD3 TSC2 COPS2 TUBG1 CLPTM1L SURF4 CACNA2D1 NSF GRAMD1A GEMIN5 SPAG5 LIFR AAAS MTOR FANCI DOCK7 UBE3C ATP1A1 ARHGEF2 SNRPA1

5.05e-0714402202730833792
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

CPNE8 CLPTM1L SURF4 SEC16A GEMIN5 MTOR DOCK7 SMARCA2 ATP1A1 ARHGEF2

7.22e-072022201033005030
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

HBS1L NUP85 CLPTM1L NMT1 EEFSEC NRDC RBL1 DOCK10 SPAG5 RFWD3 TMEM177 PRKAA1 DOCK7 TCF25 GALNT6 ARHGEF2 DHX34

9.95e-076502201738777146
Pubmed

Defining the membrane proteome of NK cells.

HBS1L CAND1 NUP85 USP9X HLA-DRB3 B2M EIF3E PSMD3 CLPTM1L SGMS1 GLIPR1 SLC37A1 WWP2 DOCK10 GEMIN5 AAAS MTOR PREP FANCI CHID1 DHX34 IL6ST NCKAP1L

1.67e-0611682202319946888
Pubmed

Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.

TBRG4 CAND1 B2M SEC16A NMT1 ALOX12B DSC1 FAF1 MTOR UBE3C

1.84e-062242201032941674
Pubmed

Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.

DDX59 CAND1 USP9X EIF3E PSMD3 TUBG1 GINS4 MRPS24 MTBP

1.91e-06175220937866880
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

MCMBP TMA16 CAND1 NUP85 EIF3E PSMD3 COPS2 SUPT6H DSC1 NRDC ADAMTS1 NSF FAM210A NUP88 FAF1 TADA1 FANCI DOCK7 SMARCA2 ARHGEF2 SNRPA1

1.93e-0610052202119615732
Pubmed

Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.

TUBG2 TUBG1 CPLANE1

2.47e-065220325877302
Pubmed

Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.

IL31 LIFR IL6ST

2.47e-065220315184896
Pubmed

HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.

NUP85 TUBG2 TUBG1

2.47e-065220314767062
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

RELN PLXND1 PLXNA2 PLXNA3

3.48e-0617220411683995
Pubmed

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.

TSC2 MTOR PRKAA1

4.92e-066220323878245
Pubmed

CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.

TUBG2 TUBG1 MTOR

4.92e-066220336334595
Pubmed

DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.

TUBG2 TUBG1 DOCK7

4.92e-066220322842144
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

HBS1L DDX59 NUP85 USP9X SUPT6H SEC16A HECTD4 NUP88 GEMIN5 AAAS SMARCA2 ARHGEF2 TRMT61A

5.30e-064402201334244565
Pubmed

Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche.

TUBG2 TUBG1 LIFR IL6ST

8.57e-0621220425127137
Pubmed

Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.

TSC2 MTOR PRKAA1

8.58e-067220322791749
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

MANBA TSC2 PLXND1 CLPTM1L FAT1 PTPRJ SURF4 PGAP1 TMCO3 GLIPR1 PLXNA3 CACNA2D1 GRAMD1A SPAG5 LIFR FANCI TMEM131 CHID1 ATP1A1 PRAF2 CSGALNACT1 IL6ST

8.88e-0612012202235696571
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CPAMD8 CAND1 RTEL1 TASOR2 PTPRB SGMS1 PTPRJ PTPRN2 PROM2 SUPT6H ABCC8 KATNIP BAIAP3 ADGRD1 WNK2 ARAP1 PMS2P2 SLC37A1 WWP2 HECTD4 FAF1 SMARCA2 UBE3C NRG3 VPS13B

9.45e-0614892202528611215
Pubmed

Co-adaptor driven assembly of a CUL3 E3 ligase complex.

CAND1 USP9X PHKA1 SEC16A

1.04e-0522220435120648
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

B2M NDRG2 CLPTM1L ABCC8 TMCO3 SLC37A1 GRAMD1A NUP88 GRIN1 OPRM1 WDR19 TMEFF1 BAZ2A SLC15A4 ATP1A1 PCDH9

1.08e-056972201628298427
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

HIPK1 SEC16A NAV3 KATNIP BAIAP3 PLXNA2 DOCK10 BAZ2A DOCK7 TCF25 UBE3C VPS13B

1.25e-054072201212693553
Pubmed

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

TUBG2 PSMD3 TUBG1 SURF4 CCDC138 SEC16A GEMIN5 AAAS SNRPA1

1.37e-05223220934226595
Pubmed

Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.

TSC2 MTOR PRKAA1

1.37e-058220320622004
Pubmed

Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.

HTR1B HTR1D S1PR1

1.37e-058220311854302
Pubmed

A HECT domain E3 enzyme assembles novel polyubiquitin chains.

CAND1 USP9X UBE3C

1.37e-058220311278995
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

HBS1L MCMBP TMA16 CAND1 NUP85 USP9X EIF3E PSMD3 IFT46 COPS2 TUBG1 SEC16A EXOSC4 NRDC ICE2 NUP88 GINS4 FAF1 MRPS24 TCF25 ATP1A1 ARHGEF2 SNRPA1

1.47e-0513352202329229926
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CAND1 NUP85 USP9X EIF3E PSMD3 TUBG1 SUPT6H NSF GEMIN5 FAF1 MTOR FANCI UBE3C ATP1A1 SNRPA1

1.55e-056382201533239621
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

HBS1L MCMBP CAND1 NUP85 USP9X EIF3E PSMD3 COPS2 TUBG1 SEC16A NMT1 EXOSC4 NRDC NUP88 LDHAL6B GINS4 GEMIN5 FAF1 MTOR FANCI UBE3C SNRPA1 KIF13A TRMT61A

1.92e-0514552202422863883
Pubmed

Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency.

TSC2 MTOR PRKAA1

2.04e-059220324209762
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

MCMBP TBRG4 USP9X SEC16A NMT1 WWP2 NUP88 GEMIN5 FANCI TMEM131 ARHGEF2 SNRPA1 KIF13A

2.18e-055032201316964243
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NUP85 TSC2 PLXND1 TUBG1 DACT1 FAT1 PIK3C2B PROM2 SEC16A WNK2 ARAP1 PLXNA3 MEX3D HECTD4 GEMIN5 MTOR FANCI UBE3C ARHGEF2 DHX34

2.74e-0511052202035748872
Pubmed

Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1.

TUBG2 TUBG1 RHO

2.90e-0510220320592197
Pubmed

Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells.

RELN TUBG2 TUBG1

2.90e-0510220322479190
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

CPNE8 CAND1 NUP85 RBM12B USP9X PSMD3 SUPT6H SURF4 SEC16A UCK2 CACNA2D1 NSF AAAS PRKAA1 DOCK7 CKAP2L ATP1A1 ARHGEF2 SNRPA1

3.14e-0510242201924711643
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

USP9X PSMD3 TSC2 CACNA2D1 ADAMTS1 WWP2 FANCI DOCK7 UBE3C ARHGEF2

3.41e-053132201038270169
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

MCMBP CAND1 MTHFD2 TSC2 UCK2 EXOSC4 NSF NUP88 AAAS MTOR FANCI TCF25 TMEM131 UBE3C

3.60e-056062201436538041
Pubmed

Exome sequencing in four families with neurodevelopmental disorders: genotype-phenotype correlation and identification of novel disease-causing variants in VPS13B and RELN.

RELN VPS13B

3.98e-052220238771357
Pubmed

Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer: a case-control study in northeast Chinese male population.

CLPTM1L TERT

3.98e-052220224861918
Pubmed

The phe-124-Cys and A-161T variants of the human 5-HT1B receptor gene are not major determinants of the clinical response to sumatriptan.

HTR1B HTR1D

3.98e-052220217501853
Pubmed

Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.

MTOR PRKAA1

3.98e-052220232962728
Pubmed

Exenatide inhibits the growth of endometrial cancer Ishikawa xenografts in nude mice.

MTOR PRKAA1

3.98e-052220226648451
Pubmed

Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population.

CLPTM1L TERT

3.98e-052220225966219
Pubmed

The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema.

CLPTM1L TERT

3.98e-052220221622582
Pubmed

Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells.

NMT1 MTOR

3.98e-052220230154572
Pubmed

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

HTR1B HTR1D

3.98e-05222021652050
Pubmed

TERT-rs33963617 and CLPTM1L-rs77518573 reduce the risk of non-small cell lung cancer in Chinese population.

CLPTM1L TERT

3.98e-052220231935503
Pubmed

Loss of TSC2 confers resistance to ceramide and nutrient deprivation.

TSC2 MTOR

3.98e-052220223604129
Pubmed

RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population.

RTEL1 TERT

3.98e-052220223812731
Pubmed

MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.

TUBG2 TUBG1

3.98e-052220217442887
Pubmed

[Regulatory effect of thymosin α1 on expression of tlr9/ido mRNA in bone marrow mesenchymal stem cells from children with aplastic anemia].

IDO1 TLR9

3.98e-052220221176371
Pubmed

Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells.

S1PR1 MTOR

3.98e-052220224567529
Pubmed

mTORC2 is required for proliferation and survival of TSC2-null cells.

TSC2 MTOR

3.98e-052220221482669
Pubmed

Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.

RHO PRKAA1

3.98e-052220228065882
Pubmed

A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.

CLPTM1L TERT

3.98e-052220226545403
Pubmed

Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.

ALOX12B ALOXE3

3.98e-052220211773004
Pubmed

The LKB1 tumor suppressor negatively regulates mTOR signaling.

TSC2 PRKAA1

3.98e-052220215261145
Pubmed

Genetic variant rs401681 at 5p15.33 modifies susceptibility to lung cancer but not esophageal squamous cell carcinoma.

CLPTM1L TERT

3.98e-052220224386361
Pubmed

RUNX1 promotes proliferation and migration in non-small cell lung cancer cell lines via the mTOR pathway.

RUNX1 MTOR

3.98e-052220237801076
Pubmed

Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.

CLPTM1L TERT

3.98e-052220221771723
Pubmed

Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.

HTR1B HTR1D

3.98e-052220225268648
Pubmed

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.

WWP2 S1PR1

3.98e-052220221555855
Pubmed

Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells.

MTOR SMARCA2

3.98e-052220236587526
Pubmed

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.

TSC2 MTOR

3.98e-052220223699409
Pubmed

Early changes of LIFR and gp130 in sciatic nerve and muscle of diabetic mice.

LIFR IL6ST

3.98e-052220221565387
Pubmed

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility.

CLPTM1L TERT

3.98e-052220225940397
Pubmed

Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China.

CLPTM1L TERT

3.98e-052220223555636
Pubmed

Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry.

CLPTM1L TERT

3.98e-052220222134622
Pubmed

Association of TERT-CLPTM1L and 8q24 Common Genetic Variants with Gallbladder Cancer Susceptibility and Prognosis in North Indian Population.

CLPTM1L TERT

3.98e-052220229450669
Pubmed

[An experimental study on the regulation of bone marrow-derived mesenchymal stem cells through indoleamine 2,3-dioxygenase signaling pathway by thymosin α1 for improving the immunosuppression mediated by T cell].

IDO1 TLR9

3.98e-052220221575365
Pubmed

Polymorphisms of TERT and CLPTM1L and the risk of hepatocellular carcinoma in Chinese males.

CLPTM1L TERT

3.98e-052220225339005
Pubmed

Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte.

TUBG2 TUBG1

3.98e-052220217287496
Pubmed

The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population.

CLPTM1L TERT

3.98e-052220223359026
Pubmed

Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population.

CLPTM1L TERT

3.98e-052220223433592
Pubmed

SPAG5 upregulation predicts poor prognosis in cervical cancer patients and alters sensitivity to taxol treatment via the mTOR signaling pathway.

SPAG5 MTOR

3.98e-052220224853425
Pubmed

Genetic variants in TERT-CLPTM1L genetic region associated with several types of cancer: a meta-analysis.

CLPTM1L TERT

3.98e-052220223707794
Pubmed

Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.

TUBG2 TUBG1

3.98e-052220228119396
Pubmed

Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.

CLPTM1L TERT

3.98e-052220225487306
Pubmed

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

LIFR IL6ST

3.98e-05222021915266
Pubmed

Role of energy- and nutrient-sensing kinases AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in adipocyte differentiation.

MTOR PRKAA1

3.98e-052220223671028
Pubmed

Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway.

TSC2 MTOR

3.98e-052220222287548
Pubmed

IDO1 involvement in mTOR pathway: a molecular mechanism of resistance to mTOR targeting in medulloblastoma.

IDO1 MTOR

3.98e-052220227174915
Pubmed

Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.

TSC2 MTOR

3.98e-052220225972538
Pubmed

Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations.

CLPTM1L TERT

3.98e-052220226621837
Pubmed

The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.

ALOX12B ALOXE3

3.98e-052220224021977
Pubmed

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

HTR1B HTR1D

3.98e-05222021565658
Pubmed

Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMP-activated protein kinase and mTOR signaling pathways.

MTOR PRKAA1

3.98e-052220221470048
Pubmed

mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.

TSC2 MTOR

3.98e-052220227023784
Pubmed

Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme.

CLPTM1L TERT

3.98e-052220221332924
Pubmed

Involvement of mTOR and Regulation by AMPK in Early Iodine Deficiency-Induced Thyroid Microvascular Activation.

MTOR PRKAA1

3.98e-052220227035650
Pubmed

TERT-CLPTM1L Rs401681 C>T polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population.

CLPTM1L TERT

3.98e-052220225007268
Pubmed

Toll-like receptor 9 is required for opioid-induced microglia apoptosis.

TLR9 OPRM1

3.98e-052220221559519
Pubmed

Meta-analysis combining new and existing data sets confirms that the TERT-CLPTM1L locus influences melanoma risk.

CLPTM1L TERT

3.98e-052220221993562
Pubmed

12R-lipoxygenase deficiency disrupts epidermal barrier function.

ALOX12B ALOXE3

3.98e-052220217403930
Pubmed

Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population.

CLPTM1L TERT

3.98e-052220223908149
Pubmed

Gene knockout analysis of two gamma-tubulin isoforms in mice.

TUBG2 TUBG1

3.98e-052220215893303
InteractionHTR1D interactions

HTR1B HTR1D S1PR1

4.49e-0642113int:HTR1D
InteractionDEFB135 interactions

MANBA FAT1 PLXNA2 PLXNA3 CACNA2D1 SUSD1

4.70e-06422116int:DEFB135
InteractionCD274 interactions

TBRG4 CAND1 NUP85 USP9X B2M SEC16A NMT1 ALOX12B DSC1 DOLK FAF1 MTOR DOCK7 UBE3C ATP1A1

8.58e-0636921115int:CD274
InteractionDEFA1 interactions

MCMBP MANBA PLXNA2 CACNA2D1 LIFR LRIG1 SUSD1 TMEM131

1.03e-051002118int:DEFA1
InteractionTNFSF13B interactions

CAND1 NUP85 TSC2 GRAMD1A GEMIN5 MTOR TMEM131 UBE3C

3.67e-051192118int:TNFSF13B
InteractionEDDM3A interactions

PLXNA2 PLXNA3 CACNA2D1 SUSD1 GALNT6

3.98e-05372115int:EDDM3A
GeneFamilyPlexins

PLXND1 PLXNA2 PLXNA3

3.53e-0591383683
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRB PTPRJ PTPRN2

5.23e-04211383813
GeneFamilyArachidonate lipoxygenases

ALOX12B ALOXE3

8.50e-0461382407
GeneFamilyNucleoporins

NUP85 NUP88 AAAS

1.84e-033213831051
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEAL1 WDR81

2.01e-03913821230
ToppCellEndothelial|World / shred by cell class for bronchial biopsy

SPNS2 B2M PLXND1 PCDH12 PTPRB NAV3 ADGRF5 S1PR1 LIFR CSGALNACT1

4.81e-0819521910f0e46e859f7a9bdead3203889f7e20fa21f76ff0
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

CPAMD8 IDO1 SPNS2 PTPRB PIK3C2B ADAMTS1 S1PR1 LIFR CSGALNACT1

3.40e-0718421990f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

CPAMD8 CPNE8 PTPRB PIK3C2B ADGRF5 PLXNA2 ADAMTS1 S1PR1 CSGALNACT1

3.90e-07187219940ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellControl-Endothelial_cells-Arterial_endothelial_cells|Control / group, cell type (main and fine annotations)

CPAMD8 IDO1 PTPRB PIK3C2B PLXNA2 ADAMTS1 S1PR1 LIFR CSGALNACT1

3.90e-07187219981affaab3fe3e1daea45ada6445e906ddd33950e
ToppCellfacs-Heart-RA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3C2B ADGRF5 ADAMTS1 S1PR1 BCO1 LIFR LRIG1 CSGALNACT1 IL6ST

4.08e-0718821994ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCellfacs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3C2B ADGRF5 ADAMTS1 S1PR1 BCO1 LIFR LRIG1 CSGALNACT1 IL6ST

4.08e-071882199e47e66906922d5c69b1aafe28face0787d3fc563
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CPAMD8 IDO1 PTPRB PIK3C2B PLXNA2 ADAMTS1 S1PR1 LIFR CSGALNACT1

4.66e-07191219950601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPNS2 PTPRB NYNRIN ADGRF5 ADAMTS1 RASGEF1A S1PR1 LIFR IL6ST

4.66e-0719121999fc674a58f20b47255e4457d5195c8cff17b0414
ToppCelldroplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPNS2 PTPRB NYNRIN ADGRF5 ADAMTS1 RASGEF1A S1PR1 LIFR IL6ST

4.66e-071912199c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

CPAMD8 SPNS2 B2M PTPRB PIK3C2B ADGRF5 PLXNA2 LIFR NRG3

4.66e-071912199c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPNS2 APC2 PTPRB NYNRIN ADAMTS1 RASGEF1A S1PR1 LIFR IL6ST

4.87e-0719221991990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

CPAMD8 SPNS2 B2M PTPRB PIK3C2B ADGRF5 PLXNA2 LIFR NRG3

4.87e-0719221998a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPNS2 APC2 PTPRB NYNRIN ADAMTS1 RASGEF1A S1PR1 LIFR IL6ST

4.87e-071922199845cc9c18b4436b07dd3ce7980052683937546d2
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPNS2 APC2 PTPRB NYNRIN ADAMTS1 RASGEF1A S1PR1 LIFR IL6ST

4.87e-071922199c72a082c93a8825adbfef37f889ba3a7052f201b
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PTPRB ADGRF5 PLXNA2 ADAMTS1 RASGEF1A S1PR1 LIFR IL6ST

4.87e-071922199945153c41dde6e90d103206955e1707b54eb0665
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PTPRB ADGRF5 PLXNA2 ADAMTS1 RASGEF1A S1PR1 LIFR IL6ST

4.87e-0719221996ab50579c63f31ca2cd41063a99b129f11c07510
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature_venous_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CPNE8 GIMAP2 SPNS2 PLXND1 PCDH12 PTPRB NAV3 ADGRF5 NRG3

5.78e-07196219985b697db1c925eff8bbef9d74565c82be5a0ddcc
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PCDH12 PTPRB PIK3C2B ADGRF5 PLXNA2 ADAMTS1 LIFR IL6ST

6.04e-071972199d584d0334ea97e3fa8c4cd869f5eeea2c7a1ed04
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PCDH12 PTPRB PIK3C2B ADGRF5 PLXNA2 ADAMTS1 LIFR IL6ST

6.04e-071972199412091994196a06c2779b4c2cfed84be889a5f8d
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

TDRD9 SPNS2 FAT1 SGMS1 DNAH6 PLXNA2 CACNA2D1 BCO1 SUSD1

6.04e-0719721996b6504c47c309bac4f790e2f372d454bbdea49e8
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CYP11A1 NDRG2 HEPH PHKA1 ETNPPL CHST1 S1PR1 LRIG1 PCDH9

6.04e-071972199bd7e18a0fed085cfb8ed0e478d1f172a173febbe
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CYP11A1 NDRG2 HEPH PHKA1 ETNPPL CHST1 S1PR1 LRIG1 PCDH9

6.04e-0719721997e06aee2add54eeff4a9927d9b04b5797160113b
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Astrocyte|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CYP11A1 NDRG2 HEPH PHKA1 ETNPPL CHST1 S1PR1 LRIG1 PCDH9

6.04e-0719721995bcf963f21d23edafef1e90dc1de24cd3b0fccce
ToppCellParenchyma_COVID-19-Endothelial-TX-Endothelial-2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

IDO1 SPNS2 B2M PCDH12 PTPRB ADGRF5 S1PR1 OPRM1 LIFR

6.57e-071992199edb68a4f622a494f22fd7b25bc40ae0d58456cdb
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IDO1 SPNS2 B2M PCDH12 PTPRB ADGRF5 S1PR1 OPRM1 LIFR

6.57e-07199219945f9c03d2ed2d98d66086fb0251bd24e30c6f775
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IDO1 SPNS2 B2M PCDH12 PTPRB ADGRF5 S1PR1 OPRM1 LIFR

6.57e-071992199448dd5a27d57627468c6b8347f1b6b1005aea004
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ATP10B EFHB DLEC1 HEPHL1 DNAH6 NSUN7 LRRC9 ADGB GALNT6

6.85e-07200219972c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TDRD9 EFHB DLEC1 CAPS2 DNAH6 ALOX12B NSUN7 LRRC9 ADGB

6.85e-07200219996701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ATP10B EFHB DLEC1 HEPHL1 DNAH6 NSUN7 LRRC9 ADGB GALNT6

6.85e-072002199da12821e8a0657869ca0f75d351cce2d7605a505
ToppCell343B-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

IDO1 SPNS2 B2M SYDE2 COL27A1 GRAMD1A GRIN1 S1PR1

1.98e-061692198e68e6c24606fd46eca6f86bb63fa86ea17879ae2
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CPAMD8 IDO1 PTPRB PIK3C2B PLXNA2 ADAMTS1 S1PR1 LIFR

3.87e-061852198a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

SPNS2 B2M PLXND1 PTPRB ADGRF5 PLXNA2 NRG3 IL6ST

4.19e-0618721987876dcb4800c2e54874df3d933efb79307a64a97
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D175|Adult / Lineage, Cell type, age group and donor

SPNS2 PCDH12 FAT1 PTPRB PIK3C2B ABCC8 S1PR1 NRG3

4.19e-061872198f3548817f2fded5978137bb252cb628ac199e4f6
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN SPNS2 PLXND1 PCDH12 PTPRB ADGRF5 PLXNA2 S1PR1

4.53e-06189219828b9e96a5206b7fdae9b17daf05c8f5d24b6c5ec
ToppCellCOVID-19-Endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

CPAMD8 SPNS2 PTPRB PIK3C2B ADGRF5 PLXNA2 LIFR NRG3

4.71e-0619021989fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCellCOPD-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

CPAMD8 IDO1 PTPRB PTPRJ ADAMTS1 S1PR1 LIFR ATP1A1

4.90e-061912198ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE8 PLXND1 PCDH12 PTPRB PIK3C2B NYNRIN ADGRF5 IL6ST

5.09e-0619221985890076929598e88fe9d59a4e4e858b446746ce9
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

CPAMD8 IDO1 PTPRB PTPRJ PIK3C2B ADAMTS1 LIFR ATP1A1

5.09e-0619221987e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE8 B2M PLXND1 PCDH12 PTPRB ADGRF5 S1PR1 SMARCA2

5.09e-061922198e4dd24aefdf13cd4206714f02fde2288f3173ffc
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MANBA PTPRJ RUNX1 FAF1 CORIN SSH2 VPS13B IL6ST

5.29e-061932198779276e775cb2492e8dd36436295a536084a6415
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EFHB DLEC1 CPLANE1 DNAH6 SDK1 PLXNA2 ADGB LRIG1

5.29e-061932198ea345d34440b25f65358a53dc72831998d1c3620
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE8 PLXND1 PCDH12 PTPRB PIK3C2B ADGRF5 LIFR IL6ST

5.29e-061932198d5f6d6e2c36d4e80af4d39cdfc0b18df295a587b
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PCDH12 PTPRB PIK3C2B NYNRIN ADGRF5 PLXNA2 IL6ST

5.29e-061932198d485634c564b268e344b6a2863c26f6adaec9e38
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE8 PLXND1 PCDH12 PTPRB PIK3C2B ADGRF5 LIFR IL6ST

5.29e-0619321984a8c97ff2dffc5c06351d1cb107e21e58250aa55
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN PLXND1 PTPRB ADGRF5 PLXNA2 BCO1 LIFR IL6ST

5.29e-0619321982483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCellFetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CPNE8 SPNS2 PLXND1 PTPRB PIK3C2B ADGRF5 GRAMD1A CSGALNACT1

5.29e-061932198ad2df9b77999780860141be6ec366afc0172a331
ToppCellIPF-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

SPNS2 PTPRB ABCC8 NAV3 ADAMTS1 S1PR1 LIFR NRG3

5.29e-061932198ef66a46e7ab44fcc4005a23416e6da478a4cce37
ToppCellPCW_05-06-Endothelial|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CPNE8 SPNS2 PLXND1 PCDH12 PTPRB ADGRF5 NRG3 CSGALNACT1

5.49e-06194219800291c62795a55a7e63b1db10c139d6a3298e55e
ToppCell(6)_Endothelial-B_(Artery)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

CPAMD8 IDO1 PTPRB PIK3C2B PLXNA2 ADAMTS1 S1PR1 LIFR

5.49e-0619421980cf4e67d4024652794b5bfdd4a71a7d98900b4c8
ToppCellPCW_05-06-Endothelial-Endothelial_immature|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CPNE8 GIMAP2 SPNS2 PLXND1 PCDH12 PTPRB ADGRF5 CSGALNACT1

5.49e-0619421989bd25ea57f2da27bd200d1a8bf797fec77d172c7
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

B2M PLXND1 PTPRB ADGRF5 PLXNA2 ADAMTS1 NRG3 IL6ST

5.49e-061942198b6cc849fa08599bff9839ef382d190cc964e273e
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPNS2 PTPRB ADGRF5 RASGEF1A S1PR1 TMEFF1 LIFR ATP1A1

5.70e-06195219852b2bbf12e5f86c493f6634697aeb23a68cc916d
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PTPRB ADGRF5 PLXNA2 ADAMTS1 RASGEF1A S1PR1 IL6ST

5.70e-0619521984db30b3bc65c25626f828cd4f867f20c71809898
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPNS2 PTPRB ABCC8 ADAMTS1 GRAMD1A S1PR1 LIFR IL6ST

5.70e-06195219853b83e16b350100b1d5791a9c42bd98e37cbc0af
ToppCellEndothelial-F|World / shred on cell class and cell subclass (v4)

IDO1 SPNS2 B2M PTPRB ADGRF5 RASGEF1A S1PR1

5.82e-06139219732d3c5d35e6c4205711c3500d736fd108443e6b4
ToppCellfacs-Lung-ENDOMUCIN-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPNS2 PTPRB ADGRF5 RASGEF1A S1PR1 TMEFF1 LIFR ATP1A1

5.92e-061962198f6df26ab9eebae893768a4f70a064ce9f60da93c
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PCDH12 PTPRB PIK3C2B ADGRF5 ADAMTS1 LIFR IL6ST

5.92e-06196219881900dcc9451ff6606ec940c16b559d73247590e
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IDO1 SPNS2 ZSWIM2 PLXND1 PTPRB ADGRF5 S1PR1 LIFR

5.92e-061962198c5fe470f11ee4962bcfb30cddfd8c078af5b1222
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPAMD8 PTPRB PIK3C2B ADGRF5 ADAMTS1 S1PR1 LIFR CSGALNACT1

5.92e-061962198cf7f384c1771274e766bab03ecc3dfbd13f2df60
ToppCellASK454-Endothelial-Endothelium|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

SPNS2 PLXND1 PCDH12 PTPRB ADGRF5 CAPS2 ADAMTS1 LIFR

5.92e-0619621982b777a2026b56839112fd179f2db482c49f4594a
ToppCellfacs-Lung-ENDOMUCIN|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPNS2 PTPRB ADGRF5 RASGEF1A S1PR1 TMEFF1 LIFR ATP1A1

5.92e-06196219869f03546c42c942ab8ac8746167c8d44d574b4c6
ToppCellFetal_29-31_weeks-Endothelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RELN SPNS2 PLXND1 PCDH12 PTPRB PIK3C2B ADGRF5 NRG3

5.92e-0619621983981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PTPRB SGMS1 ADGRF5 ADAMTS1 S1PR1 LIFR IL6ST

6.14e-061972198a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

CPAMD8 CPNE8 SPNS2 B2M PTPRB ADGRF5 PLXNA2 LIFR

6.14e-061972198f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PTPRB SGMS1 ADGRF5 ADAMTS1 S1PR1 LIFR IL6ST

6.14e-061972198deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCellPCW_10-12-Endothelial-Endothelial_cycling-endo_proliferating2_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CPNE8 SPNS2 PCDH12 PTPRB ADGRF5 KNL1 SPAG5 CKAP2L

6.14e-061972198491e12a5fca06b86443c0173f5fa750ea3b8a715
ToppCell5'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CPNE8 RELN PLXND1 PCDH12 PTPRB ADGRF5 ADAMTS1 S1PR1

6.38e-06198219890e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PTPRB SGMS1 ADGRF5 ADAMTS1 S1PR1 LIFR IL6ST

6.38e-061982198f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Capillary-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SPNS2 B2M PCDH12 PTPRB ABCC8 ADGRF5 S1PR1 LIFR

6.62e-061992198993999adf346b4fd557989bc53c17eb0ccb996c9
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

B2M PLXND1 PCDH12 PTPRB ADGRF5 S1PR1 LIFR IL6ST

6.62e-06199219814e09eaa2335d4503de50250eb4258dd5b85b304
ToppCelldistal-2-Endothelial-Artery|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CPAMD8 IDO1 PTPRB PIK3C2B ADAMTS1 S1PR1 LIFR ATP1A1

6.62e-061992198fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Capillary|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

SPNS2 B2M PCDH12 PTPRB ABCC8 ADGRF5 S1PR1 LIFR

6.62e-06199219889f4db619fbed90f7fdf6ece7a671e514b5c6d76
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Capillary|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SPNS2 B2M PCDH12 PTPRB ABCC8 ADGRF5 S1PR1 LIFR

6.62e-0619921983fea92affacd4c1f588fa81807df35d6c69b7241
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

B2M PLXND1 PCDH12 PTPRB ADGRF5 S1PR1 LIFR IL6ST

6.62e-061992198e6715288a586631676722f2323f0d833431161cf
ToppCelldistal-Endothelial-Artery-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CPAMD8 IDO1 PTPRB PIK3C2B ADAMTS1 S1PR1 LIFR ATP1A1

6.62e-0619921983788f3218356aaaa10684e48d63757037f8a3a3c
ToppCellParenchyma_COVID-19-Endothelial-TX-Artery|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

CPAMD8 IDO1 PTPRB PIK3C2B ADGRF5 ADAMTS1 S1PR1 LIFR

6.86e-06200219834b279804475ea58fbb052b96f44128c082627a9
ToppCell3'-Adult-LargeIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PLXND1 PTPRB ADGRF5 ADAMTS1 S1PR1 LIFR IL6ST

6.86e-06200219874a3b9ec8faa1d187ad8b0d12f5c89bde2d7248e
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Artery|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CPAMD8 IDO1 PTPRB PIK3C2B ADGRF5 ADAMTS1 S1PR1 LIFR

6.86e-0620021988552cc7a439449b30b59760c3e8667217b9852b5
ToppCelldistal-Endothelial-Vein-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SPNS2 PTPRB PIK3C2B ABCC8 ADAMTS1 S1PR1 LIFR IL6ST

6.86e-062002198ff88d28162e0231d5dac0e0c6bec98fa8da58a23
ToppCellkidney_cells-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

B2M PLXND1 PCDH12 PTPRB ADGRF5 S1PR1 LIFR IL6ST

6.86e-0620021989f1626a7e1bd00977a5c316cafbdf654b52bad94
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Artery-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CPAMD8 IDO1 PTPRB PIK3C2B ADGRF5 ADAMTS1 S1PR1 LIFR

6.86e-06200219845c08f1befe78553bbadcc2fcffb6138306638f3
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CPAMD8 IDO1 PTPRB PIK3C2B ADGRF5 ADAMTS1 S1PR1 LIFR

6.86e-0620021987547d6339f9380d031cfd2cce21ac9a12491e085
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

B2M PLXND1 PCDH12 PTPRB ADGRF5 S1PR1 LIFR IL6ST

6.86e-0620021983007583eaad3a5ae2df010513d3e4df59155123d
ToppCellfacs-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC29A3 DDX59 MCUB GLIPR1 DOCK10 TLR9 TERT

1.65e-051632197f558ad9569e5137e62a601ba4f073e69ed8f8650
ToppCellAdult-Epithelial-lung_goblet_cell-D122|Adult / Lineage, Cell type, age group and donor

SPNS2 NDRG2 FER1L6 PROM2 SDK1 WNK2 GALNT6

1.93e-0516721976efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 PTPRB PIK3C2B ADGRF5 HEPHL1 PLXNA2 S1PR1

2.08e-051692197c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EFHB DLEC1 CAPS2 DNAH6 BAIAP3 NSUN7 ADGB

2.08e-05169219714aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP30 MCUB KNL1 DOCK10 RUNX1 SPAG5 NCKAP1L

2.16e-0517021979e94fa0d05abed3438b28296a293767096d517d6
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTHFD2 ABCC8 RBL1 RFWD3 ABHD5 FANCI CKAP2L

2.24e-051712197913bae728b5e653771a27c79a309eb023699f1d0
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYDE2 CAPS2 CPLANE1 DNAH6 BAIAP3 HEATR4 LRRC9

2.24e-0517121971854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTHFD2 ABCC8 RBL1 RFWD3 ABHD5 FANCI CKAP2L

2.24e-051712197f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRR5L PTPRJ ADAMTS1 DOCK10 RUNX1 LIFR SSH2

2.42e-051732197869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRR5L PTPRJ ADAMTS1 DOCK10 RUNX1 LIFR SSH2

2.42e-0517321970672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRR5L PTPRJ ADAMTS1 DOCK10 RUNX1 LIFR SSH2

2.42e-051732197870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NYNRIN UCK2 MCUB ADGRD1 RUNX1 WDR19 TMEM131

2.51e-051742197a9f34d1237f335d27c5560ff514368f4709f9144
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D175|Adult / Lineage, Cell type, age group and donor

CPAMD8 HEPH PTPRB PIK3C2B ADAMTS1 LIFR CSGALNACT1

2.60e-0517521970a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRR5L PTPRJ NAV3 ADAMTS1 RUNX1 LIFR SSH2

2.60e-0517521971ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCelldroplet-Fat-Gat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFP69 CCDC138 ADGRF5 LNX2 S1PR1 LPAR2 TRMT61A

3.01e-05179219708cf9986804a6417a9afb19b50c69a3554f71ec6
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CPAMD8 CPNE8 PTPRB PIK3C2B ADAMTS1 S1PR1 CSGALNACT1

3.01e-0517921972a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CPNE8 TUBG2 CLK4 SGMS1 RUNX1 SUSD1 CSGALNACT1

3.11e-05180219762511d76d24b836839c3dcc2bf30485ffe9401e2
DiseaseICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2

ALOX12B ALOXE3

5.09e-0522112242100
DiseaseAutosomal recessive congenital ichthyosis 2

ALOX12B ALOXE3

5.09e-0522112cv:C3888093
DiseaseICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1

ALOX12B ALOXE3

5.09e-0522112C1855792
Diseasecomplex cortical dysplasia with other brain malformations 4 (implicated_via_orthology)

TUBG2 TUBG1

5.09e-0522112DOID:0090138 (implicated_via_orthology)
DiseaseStuve-Wiedemann syndrome

LIFR IL6ST

5.09e-0522112cv:C0796176
Diseasegestational age

DLEC1 SDK1 EEFSEC COL27A1 FAF1 PREP CKAP2L

6.35e-051382117EFO_0005112
Diseaseamino acid measurement

PRR5L PTPRB PER3 PTPRJ PTPRN2 NAV3 PLXNA2 WNK2 CACNA2D1 HTR1B WWP2 LRIG1 SUSD1 NRG3 TRMT61A

1.20e-0467821115EFO_0005134
DiseaseFocal Cortical Dysplasia of Taylor, Type IIb

TSC2 MTOR

1.52e-0432112C1846389
DiseaseFOCAL CORTICAL DYSPLASIA OF TAYLOR

TSC2 MTOR

1.52e-0432112C1846385
DiseaseFocal Cortical Dysplasia of Taylor, Type IIa

TSC2 MTOR

1.52e-0432112C1846386
DiseaseSelf-Healing Collodion Baby

ALOX12B ALOXE3

1.52e-0432112C1855789
DiseaseSchwartz-Jampel syndrome

LIFR IL6ST

1.52e-0432112cv:C0036391
DiseaseIsolated focal cortical dysplasia type II

TSC2 MTOR

1.52e-0432112cv:C1846385
DiseaseFOCAL CORTICAL DYSPLASIA, TYPE II

TSC2 MTOR

1.52e-0432112607341
Diseasebody mass index, type 2 diabetes mellitus

ARAP1 FAF1 MTOR

1.88e-04162113EFO_0004340, MONDO_0005148
Diseasetesticular carcinoma

CLPTM1L UCK2 TERT RFWD3

1.90e-04402114EFO_0005088
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

CLPTM1L FAT1 RUNX1 TERT

3.01e-04452114DOID:3748 (is_implicated_in)
DiseaseIchthyosis Congenita I

ALOX12B ALOXE3

3.02e-0442112C4551630
DiseaseHarlequin Fetus

ALOX12B ALOXE3

3.02e-0442112C0239849
Diseasehead and neck carcinoma, lung cancer

CLPTM1L TERT

3.02e-0442112MONDO_0002038, MONDO_0008903
DiseaseIchthyosis Congenita II

ALOX12B ALOXE3

3.02e-0442112C3536797
DiseaseCongenital myotonia

LIFR IL6ST

3.02e-0442112cv:CN295225
Diseaseautosomal recessive congenital ichthyosis 1 (is_implicated_in)

ABHD5 ALOXE3

3.02e-0442112DOID:0060656 (is_implicated_in)
DiseaseCollodion Fetus

ALOX12B ALOXE3

3.02e-0442112C3543867
Diseasetestosterone measurement

SLC17A2 MANBA SPNS2 CYP27B1 WDR81 RNF215 DACT1 PER3 PTPRJ NYNRIN PGAP1 ARAP1 KNL1 CACNA2D1 NRDC ICE2 S1PR1 FAF1 OPRM1 SUSD1 SMARCA2

3.47e-04127521121EFO_0004908
Diseasegallbladder carcinoma (is_implicated_in)

CLPTM1L TERT

5.02e-0452112DOID:4948 (is_implicated_in)
DiseaseCongenital ichthyosis

ALOX12B ALOXE3

5.02e-0452112C0020758
Diseasemean fractional anisotropy measurement

DACT1 NMT1 WNK2 NSF TMEM131

6.13e-04952115EFO_0008399
Diseaselung squamous cell carcinoma (is_implicated_in)

CLPTM1L PTPRJ TERT

6.53e-04242113DOID:3907 (is_implicated_in)
Diseasemyeloproliferative disorder

HBS1L RUNX1 TERT

7.38e-04252113EFO_0004251
DiseaseDiffuse interstitial pulmonary fibrosis

RTEL1 TERT

7.49e-0462112cv:C0085786
Diseasestatus epilepticus (biomarker_via_orthology)

RELN CYP11A1 ABCC8 GRIN1 IL6ST

7.74e-041002115DOID:1824 (biomarker_via_orthology)
DiseaseSeizures

CYP11A1 APC2 TSC2 HTR1B NSF OPRM1 ATP1A1

1.02e-032182117C0036572
Diseaseoral squamous cell carcinoma (is_implicated_in)

CLPTM1L FAT1 TERT

1.03e-03282113DOID:0050866 (is_implicated_in)
DiseaseInvoluntary Movements

GRIN1 OPRM1

1.04e-0372112C0427086
DiseaseHeadache, fasting blood glucose measurement

MANBA UBE3C

1.04e-0372112EFO_0004465, HP_0002315
DiseaseMyeloid Leukemia, Chronic

PER3 RUNX1 TERT

1.15e-03292113C0023473
Diseasecentral nervous system cancer, glioma

RTEL1 TERT LRIG1

1.15e-03292113EFO_0000326, EFO_0005543
Diseaseacute lymphoblastic leukemia

PTPRJ HTR1B WDR19 CSGALNACT1

1.30e-03662114EFO_0000220
Diseasegeneralized anxiety disorder (implicated_via_orthology)

HTR1B HTR1D

1.39e-0382112DOID:14320 (implicated_via_orthology)
Diseaseage at onset, glioblastoma multiforme

RTEL1 TERT

1.39e-0382112EFO_0000519, EFO_0004847
Diseasefemale breast cancer (is_implicated_in)

RTEL1 FANCI

1.39e-0382112DOID:0050671 (is_implicated_in)
DiseaseLymphoid leukemia

CLPTM1L TERT

1.39e-0382112C0023448
Diseaseosteoarthritis, spine, body mass index

PER3 ABHD5

1.39e-0382112EFO_0004340, EFO_1000787
Diseasesarcoma (is_implicated_in)

PTPRB KNL1

1.39e-0382112DOID:1115 (is_implicated_in)
Diseaseschizophrenia (implicated_via_orthology)

RELN GRIN1 MTOR NRG3

1.45e-03682114DOID:5419 (implicated_via_orthology)
DiseaseProstatic Neoplasms

B2M CLPTM1L SURF4 UCK2 ALOX12B RUNX1 TERT LIFR AAAS BAZ2A ALOXE3 IL6ST

1.70e-0361621112C0033578
DiseaseMalignant neoplasm of prostate

B2M CLPTM1L SURF4 UCK2 ALOX12B RUNX1 TERT LIFR AAAS BAZ2A ALOXE3 IL6ST

1.70e-0361621112C0376358
DiseaseHeadache, glucose measurement

MANBA FAF1

1.77e-0392112EFO_0004468, HP_0002315
Diseaseglioblastoma multiforme

RTEL1 TERT

1.77e-0392112EFO_0000519
DiseaseDyskeratosis congenita

RTEL1 TERT

1.77e-0392112cv:C0265965
Diseasecervical cancer

CLPTM1L TERT MTOR

1.83e-03342113C4048328
DiseaseUterine Cervical Neoplasm

CLPTM1L TERT MTOR

1.99e-03352113C0007873
Diseaseplatelet measurement

HBS1L DOCK10 TERT BAZ2A DOCK7 CKAP2L SIGLEC11 GALNT6

2.03e-033152118EFO_0005036
DiseaseHOYERAAL-HREIDARSSON SYNDROME

RTEL1 TERT

2.21e-03102112C1846142
DiseaseFanconi anemia (is_implicated_in)

RFWD3 FANCI

2.21e-03102112DOID:13636 (is_implicated_in)
Diseasebrain connectivity measurement

DACT1 NAV3 PLXNA2 WNK2 CACNA2D1 NSF FAF1 TCF25 SSH2

2.47e-034002119EFO_0005210
Diseaseacute insulin response measurement

ARAP1 CHST1

2.68e-03112112EFO_0006831
Diseasethrombin generation potential measurement

PTPRJ COL27A1

2.68e-03112112EFO_0005538
DiseaseCongenital Nonbullous Ichthyosiform Erythroderma

ALOX12B ALOXE3

2.68e-03112112C0079154
DiseaseCongenital ichthyosis of skin

ALOX12B ALOXE3

2.68e-03112112cv:C0020758
Diseasedeoxycholate measurement

CPAMD8 RUNX1 NSUN7

2.73e-03392113EFO_0010475
Diseasecups of coffee per day measurement

CYP11A1 HECTD4 ATP1A1

2.93e-03402113EFO_0006782
Diseasecesarean section, intelligence

TMEM132D CSGALNACT1

3.20e-03122112EFO_0004337, EFO_0009636
Diseasedecanoylcarnitine measurement

COL27A1 DHX34

3.20e-03122112EFO_0021039
Diseasepyruvate measurement

HBS1L NAV3 HTR1B WWP2 TMEM132D SMARCA2 UBE3C

3.28e-032682117EFO_0010117
DiseaseCocaine Dependence

HTR1B NSF ICE2 GRIN1 OPRM1

3.31e-031392115C0600427
Diseasespleen volume

HBS1L HECTD4 TERT

3.60e-03432113EFO_0600047
Diseaseserum albumin measurement

HBS1L CYP11A1 WDR81 PTPRJ NYNRIN CACNA2D1 GRAMD1A RUNX1 TERT NSUN7 ABCB9

3.75e-0359221111EFO_0004535
DiseaseFVC change measurement, response to placebo

RELN KATNIP

3.77e-03132112EFO_0008344, EFO_0010339
Diseasepeak insulin response measurement

CHST1 MRPS24

3.77e-03132112EFO_0008000
Diseasemultiple sclerosis

HBS1L CPAMD8 PRR5L MANBA GIMAP2 CYP27B1 SYDE2 UCK2 DOCK10 RASGEF1A TERT

3.85e-0359421111MONDO_0005301
Diseaseage at diagnosis, osteonecrosis

RELN NAV3 ABHD5

3.85e-03442113EFO_0004259, EFO_0004918
DiseaseThyroid carcinoma

TSC2 TERT MTOR

3.85e-03442113C0549473
Diseaseureteral obstruction (biomarker_via_orthology)

B2M ADAMTS1 MTOR

4.10e-03452113DOID:5199 (biomarker_via_orthology)
Diseasemiddle cerebral artery infarction (implicated_via_orthology)

ABCC8 RUNX1 MTOR

4.10e-03452113DOID:3525 (implicated_via_orthology)
DiseaseMalformations of Cortical Development

TUBG1 MTOR

4.38e-03142112C1955869
DiseaseHamman-Rich syndrome

RTEL1 TERT

4.38e-03142112C0085786
Diseasesilicosis (biomarker_via_orthology)

RTEL1 TERT

4.38e-03142112DOID:10325 (biomarker_via_orthology)
DiseasePsychosis, Brief Reactive

HTR1B GRIN1

4.38e-03142112C0033958
Diseasecentral nervous system cancer, glioblastoma multiforme

RTEL1 TERT

4.38e-03142112EFO_0000326, EFO_0000519
DiseaseCortical Dysplasia

TUBG1 MTOR

4.38e-03142112C0431380
DiseaseSchizophreniform Disorders

HTR1B GRIN1

4.38e-03142112C0036358
DiseaseTesticular Germ Cell Tumor

ALOX12B RFWD3

4.38e-03142112C1336708
DiseaseDepressive disorder

RELN SLC29A3 IDO1 PER3 HTR1B HTR1D OPRM1

4.94e-032892117C0011581
Diseaseacute graft vs. host disease, donor genotype effect measurement

SDK1 TMEM131

5.03e-03152112EFO_0004599, EFO_0007892
Diseaselung adenocarcinoma (is_implicated_in)

CLPTM1L PTPRJ TERT

5.21e-03492113DOID:3910 (is_implicated_in)
Diseasecoronary artery calcification

ZSWIM2 PTPRN2 NAV3 CAPS2 DNAH6 CACNA2D1 HTR1B DOCK10 DOCK7

5.32e-034502119EFO_0004723
DiseaseParkinson's disease (implicated_via_orthology)

HIPK1 PTPRN2 NSF OPRM1 PRKAA1

5.53e-031572115DOID:14330 (implicated_via_orthology)
DiseaseNeuralgia, Supraorbital

CACNA2D1 OPRM1

5.72e-03162112C0038870
DiseaseNeuralgia

CACNA2D1 OPRM1

5.72e-03162112C0027796
DiseaseNeuralgia, Atypical

CACNA2D1 OPRM1

5.72e-03162112C0234247
DiseaseNeuralgia, Stump

CACNA2D1 OPRM1

5.72e-03162112C0234249
DiseaseNeuralgia, Iliohypogastric Nerve

CACNA2D1 OPRM1

5.72e-03162112C0423712
DiseaseNeuralgia, Perineal

CACNA2D1 OPRM1

5.72e-03162112C0423711
DiseaseCannabis use

SDK1 CHID1

5.72e-03162112EFO_0007585
DiseaseDyskeratosis Congenita

RTEL1 TERT

5.72e-03162112C0265965
DiseaseParoxysmal Nerve Pain

CACNA2D1 OPRM1

5.72e-03162112C0751373
DiseaseNerve Pain

CACNA2D1 OPRM1

5.72e-03162112C0751372
DiseaseNeuralgia, Ilioinguinal

CACNA2D1 OPRM1

5.72e-03162112C0751371

Protein segments in the cluster

PeptideGeneStartEntry
IQRTPKIQVYSRHPA

B2M

21

P61769
ALKYVHPRSQTRDTT

AEN

201

Q8WTP8
RQYGKVLIPVHLITS

FAM210A

131

Q96ND0
IATVYRTRKLHTPAN

HTR1B

71

P28222
RVYNASSTIVPSLKH

AAAS

176

Q9NRG9
ISRPNLSVIYAHVRD

ADAM5

276

Q6NVV9
LADQPRTTKYHSVIL

PRMT2

116

P55345
RTNVLPFIQKSIYSH

CAPS2

336

Q9BXY5
YTRIHIPFISKELNI

COPS2

366

P61201
KYLHSNLIVVRTPVR

CSGALNACT1

456

Q8TDX6
IRKYVQHISLSPDSI

BAIAP3

871

O94812
QRTQVKTRTLHPVYD

BAIAP3

1066

O94812
YHPIITNLTEERKTF

ADGRD1

276

Q6QNK2
IHTYATKATVVRLPV

ADGB

731

Q8N7X0
PEVIKYLSRNVVHSV

BAZ2A

591

Q9UIF9
ITKYPLLISRILQHS

ARHGEF2

391

Q92974
LPHYNKRSTITSREI

H2BC12L

81

P57053
LKRTPATAEAQHIIY

ETNPPL

376

Q8TBG4
KCHQRRVLTYTIPIS

GRAMD1A

416

Q96CP6
VVRHPLTGEIVVYTK

ATP10B

776

O94823
PFRIGHIQYLSTIIK

NBEAL1

1016

Q6ZS30
LSLHKTVLQYRPVHI

RBM12B

341

Q8IXT5
LVTYRPDKNHTTIRS

RFWD3

651

Q6PCD5
RLYKHPSIRNSVSLV

ADAMTS1

291

Q9UHI8
VTVQHKKLRTPLNYI

RHO

61

P08100
LLHYQTVSEPAVIKR

HBS1L

601

Q9Y450
PCHTNIITILESYVK

MSL3P1

126

P0C860
VPKNRSLAVLTYDHS

PTPRN2

771

Q92932
SYRIQDSPVAHLVAI

PCDH12

496

Q9NPG4
QTHLTSRQLLYQKVP

LRRC9

1161

Q6ZRR7
IIPKNTLVTLCHYAT

CYP27B1

401

O15528
LQNYSKVERHPVTAL

NRG3

426

P56975
PLYINITVAASHKLV

FAT1

656

Q14517
HVSYKSPVILLRDLS

FANCI

1036

Q9NVI1
ILTQLHPRSQIDIYV

EXOSC4

111

Q9NPD3
HLQIVTKYILIPASQ

IDO1

346

P14902
LKPHTAYRISIRAFT

PTPRB

1571

P23467
PYDISRVKLSVQTHS

PTPRJ

1076

Q12913
TPIHIYVIIKALVTI

OPRM1

296

P35372
LIIIAKIYNNTLHTP

OR13G1

41

Q8NGZ3
APERKLTLSHIYQFV

FOXI3

161

A8MTJ6
ILSVIITILVQHKYP

GLIPR1

246

P48060
LVIPTHVRAQYVALL

LEFTY1

51

O75610
TVIYRHGLPLVTLTL

MCUB

61

Q9NWR8
LKEVNPTTHSYILVS

MAGEB4

166

O15481
QAPTIARKYFHLIVV

DOLK

331

Q9UPQ8
HPRYRETTLSLVKTV

LPAR2

226

Q9HBW0
TYSHKARLTVNVLPS

LRIG1

586

Q96JA1
IPVVHQLLTRYLKQF

NMT1

346

P30419
DIRHSSVAYLKPVQL

LMOD3

541

Q0VAK6
LTHRSNVSLLEPYQK

HIPK1

106

Q86Z02
TKLYVSPHDVDIRNT

KATNIP

506

O60303
IRVQPARILSHIYSS

PHKA1

471

P46020
LLLPHTRYTLQVNTI

ALOXE3

436

Q9BYJ1
ILKYHTEIVFARTSP

ATP1A1

681

P05023
TVLVNLYKVHGRLPV

KIAA1109

811

Q2LD37
ALTISPYHEKALVNR

FICD

166

Q9BVA6
ITTIEIHRSNPYIQL

LNX2

231

Q8N448
LYRLQQHVKVIIATP

DDX59

316

Q5T1V6
IISLRTLKIPSFHVY

DCAF4L1

101

Q3SXM0
TLKIPSFHVYVLRNL

DCAF4L1

106

Q3SXM0
HAYLSLLKQTRPVQS

CAND1

396

Q86VP6
QIYKLLLQPVHVSVS

PER3

406

P56645
HYQVSDRSVVALVPK

PLXNA2

1586

O75051
THLLTVQEPRVRAKY

PLXNA3

1046

P51805
VVLHTTRKSQVFPLS

PLXND1

811

Q9Y4D7
SSIVQYSPHCKLIIV

LDHAL6B

171

Q9BYZ2
HFLVTRLLYSNPTVK

NUP85

306

Q9BW27
SYILIIHSVLRIASP

OR51F1

226

A6NGY5
PLRYVTVLTHNRILA

OR51I1

131

Q9H343
PKSLHTLVLVFLYVN

PCDH9

761

Q9HC56
HVSSKTTLQYRSLPR

NAV3

1126

Q8IVL0
IKRIQQRTHTYIVTP

MEX3D

296

Q86XN8
RLQAYTSVAKAPLHL

NCKAP1L

491

P55160
IPLSTQDVQHITRYL

LRRC75B

161

Q2VPJ9
TKSYTIEINHRPLLE

KNL1

901

Q8NG31
IVRTSPNHRYTFTLK

NSF

36

P46459
NVAVPSHLYKVILAR

EXOG

221

Q9Y2C4
TSIVPQVLVHFLVKR

OR2D3

91

Q8NGH3
PLRYATILTDTIIAH

OR52P1

131

Q8NH57
YPSVVLSTDRVHIKL

HECTD4

2661

Q9Y4D8
AILSEISYKPRLHTT

OOSP4B

76

A0A2R8Y4Y8
RAPSNVSTIIHILYL

RELN

301

P78509
TALHRDIYPSVSLQI

CAMK1G

281

Q96NX5
YLVHLQERPVKQTIS

PIK3C2B

486

O00750
HSRVRPKVTVLNYAS

PRR5L

241

Q6MZQ0
PLHSLKFIATLQYIV

PREP

646

P48147
LYASFHLSRKPISIV

SLC37A1

31

P57057
QRRVHPQVTVYPAKT

HLA-DRB3

121

P79483
RTIKLSPTYQHVPLL

APC2

991

O95996
HSTNFVVTVLLPSKR

DNAH6

4126

Q9C0G6
NNIHSPAIRAYLKTI

IL31

81

Q6EBC2
YLIVHVPARIVNISS

IGLON5

126

A6NGN9
ILDIPVYKSRIQSLH

IFT46

246

Q9NQC8
KLVSRYHPQIALTSQ

ICE2

271

Q659A1
HFTIPKEQYTIINRT

IL6ST

71

P40189
EYQAVPVILSHLRIS

CCDC138

531

Q96M89
YILSLVQKKTHPVRT

DACT1

341

Q9NYF0
SHLFPYVKKRIQVIS

DOCK10

2006

Q96BY6
ILTTSHAFPYIKTRV

DOCK7

1966

Q96N67
PHVLLLVTQLGRYTS

GIMAP2

106

Q9UG22
IRINSPHYLTKIKLT

CAPN7

631

Q9Y6W3
FSIKAHSRLPYLVIS

CPLANE1

401

Q9H799
KVIEVSLPHTSYSIV

QRSL1

311

Q9H0R6
HRSAYVPSVADILQI

CACNA2D1

916

P54289
LLVEKQTHTAVYPSL

GJA9

286

P57773
TVYSVLHTTPAILLK

GALNT6

196

Q8NCL4
YSHEVGRPVLRTTKI

CPAMD8

276

Q8IZJ3
TATYPVIKRILHQLF

HEATR4

591

Q86WZ0
QKHYPARLPTASIVI

GALNTL5

126

Q7Z4T8
TTILLTRKLHTPANY

HTR1D

61

P28221
RLHPISVTLQRYLVN

CYP11A1

386

P05108
QTRFVKTIILHPRYS

CORIN

871

Q9Y5Q5
LHYLSNLIQSIKTPL

COL27A1

1666

Q8IZC6
PHILRYLTTAVITNK

EIF3E

251

P60228
VAYQIKRLKSHPSII

MANBA

436

O00462
LLIPHTRYTVQINSI

ALOX12B

426

O75342
VIVIHLKNFASRPYS

HEPHL1

111

Q6MZM0
QKVYLRVPSHLQAET

DSC1

31

Q08554
QIAPYLTHGIRSKIS

EFHB

316

Q8N7U6
IHNVLPYVGTSVKTL

FBXL5

321

Q9UKA1
KRNVYDLTSIPVRHQ

FAF1

221

Q9UNN5
TLVSTRHYRAPEVIL

CLK4

336

Q9HAZ1
KLDLHSYVRPAQLSV

DLEC1

1456

Q9Y238
LKLTNTTEIPHYFRL

DLEC1

1506

Q9Y238
LETLQKTSVLQRPYH

DHX34

1106

Q14147
RVLPLSVTHFYSATK

DHRS11

156

Q6UWP2
PVVRLKNLTSHTKYL

SDK1

1761

Q7Z5N4
TYVLQSLHLRIPEIS

SLC15A4

341

Q8N697
VPLVKAHRSSVSDYV

S1PR1

6

P21453
GRHVVFYPTLKSLQV

CHID1

351

Q9BWS9
APVINHVARYASSVK

CPNE8

416

Q86YQ8
RSVPLLRAISYHLVQ

TBRG4

271

Q969Z0
STILVNITEKVYPHT

LIFR

421

P42702
LHLISTVYTRRDVLP

MCMBP

371

Q9BTE3
VYHLLKRSISASINP

MTBP

46

Q96DY7
LKPYTHTAVAQVLLQ

NYNRIN

1651

Q9P2P1
HKLITLIYSVVTPVL

OR11H7

271

Q8NGC8
YNVNLPLHITSILSV

ARHGAP30

416

Q7Z6I6
PHVVLLTSDNVIRIY

NUP88

186

Q99567
YASRIIHPIVRTLDQ

MTOR

1151

P42345
YLIVKTTVQLSHPAA

KIF13A

1251

Q9H1H9
NHPVTVLIRVYIVAA

FER1L6

1351

Q2WGJ9
VRLHLQTVPSKVVYK

MRPS24

151

Q96EL2
PPQVATYHRAIKITV

RUNX1

156

Q01196
IPKIIYASRTHSQLT

RTEL1

106

Q9NZ71
LPTLFRVTKTHQLAV

SYDE2

766

Q5VT97
RVHLKTVVFQSDVYP

SLC29A3

401

Q9BZD2
IRYISELAITTRPHQ

USP9X

1966

Q93008
QHIYKTLLSIPEVVR

SPAG5

1166

Q96R06
LLNVSRIIVHPNYVT

PRSS29P

141

A6NIE9
VLNTHYVAPRRILLT

SMARCA2

866

P51531
HLLRIKPTQSVFIST

TMCO3

371

Q6UWJ1
GSQHLIRYKTIAPLV

GINS4

201

Q9BRT9
LDNSVAIHYIPKTVR

TMEM132D

286

Q14C87
TYLSILRNPVTNKKH

SNRPA1

116

P09661
IPTHTVYALNIERII

TADA1

291

Q96BN2
KRLQVYPLHSSVALE

TDRD9

411

Q8NDG6
SELIQKYRNIITHAP

NDRG2

211

Q9UN36
ATVTISHRYTPKEQL

MTHFD2

226

P13995
SHVYRSVLLKSIPRE

RBL1

876

P28749
KLLPSYRHTITVSCL

TAF2

841

Q6P1X5
ALSIYHILPETVRKQ

NSUN7

181

Q8NE18
TVSVKQLFSTLPVRH

PMS2P2

221

O95744
ILIHLKNFATRPYTI

HEPH

111

Q9BQS7
SQLLLRPVIVLHYSS

RNF215

171

Q9Y6U7
RPVIVLHYSSNVTKL

RNF215

176

Q9Y6U7
YKTLLRILLTHSTIP

TENM1

1036

Q9UKZ4
IPLYLHRAQVVQKTA

SPNS2

336

Q8IVW8
LSHLVVYVPSVRGSK

PGAP1

436

Q75T13
LLIYNHQTSRKIPVL

WDR19

121

Q8NEZ3
TKQYLPHVARLCLIS

SURF4

21

O15260
TALIQVSSRLHTPVY

OR5L2

46

Q8NGL0
TSIQSLRPHSYVKTI

ABHD5

306

Q8WTS1
KYLHRVISLVSQEPV

ABCB9

576

Q9NP78
RTVVLVTHKLQYLPH

ABCC8

881

Q09428
HIIKLYQVISTPSDI

PRKAA1

86

Q13131
KTYIHIIDQRTRQPV

BCO1

281

Q9HAY6
NSYSIATKDVIVHPL

ADGRF5

551

Q8IZF2
LIEHPSLKYATTRSI

ASPA

156

P45381
PVNRATVKALISHLY

ARAP1

1076

Q96P48
PKLQLSVYTTTRSHL

CLPTM1L

51

Q96KA5
PTFAYNLSRKTHILI

CHST1

51

O43916
RTVPSHFIRTLSKVQ

CKAP2L

276

Q8IYA6
QRTTYIKRVIAHPSF

SUPT6H

1321

Q7KZ85
HKSYRPLTVLTFRIN

TMTC4

81

Q5T4D3
PSQHVVLSLTFKRYV

EEFSEC

571

P57772
LPSHVKISVSRQTLF

WWP2

511

O00308
NVAKPSTIFHTLLYI

ZNF826P

71

Q6ZT77
TYTLIIRLRHNVIKT

PSMD3

391

O43242
QLTHIELDRVSSIYP

RASGEF1A

221

Q8N9B8
YTLVDRVPTLLQHLA

RBP3

341

P10745
KSILTQPHLYSPVLI

SEC16A

1831

O15027
PKRVEIIEYTHIVTS

SSH2

1006

Q76I76
PRVIHSILNSPYAKL

TUBG1

71

P23258
AIHTQLRSSVYPLLA

PROM2

236

Q8N271
YVRPLHTLLSALVVA

PRAF2

61

O60831
LTHLSLKYNNLTVVP

TLR9

201

Q9NR96
DYTVNVTLLRSPKRH

SUSD1

466

Q6UWL2
ITNASKFHLPVRVYT

TMEM131

521

Q92545
KFTPVHNRTVSSLII

TMEM131

941

Q92545
PHRTQILYSTDIALI

TRMT61A

81

Q96FX7
IRDTNSIKYKLPVHT

GEMIN5

526

Q8TEQ6
LPTYISTLLHVNIRD

SLC17A2

296

O00624
AFTTTLNLLPYHKIV

NRDC

1136

O43847
PVVHLSRQVKYSRLV

SGMS1

396

Q86VZ5
LPSYEQAVALTRKHS

PRRG4

186

Q9BZD6
YVRHRPTLLTTVEFL

TMEM168

146

Q9H0V1
TVQIPVYDFVSHSRK

UCK2

106

Q9BZX2
VYTPKHIVRSLPLQL

ZSWIM2

316

Q8NEG5
IEARLSISHVQQKPY

ZNF221

156

Q9UK13
THTLTSRNLPLIYVN

VPS13B

1536

Q7Z7G8
PRVIHSILNSPYAKL

TUBG2

71

Q9NRH3
YTNNPLEKTVVRALH

TASOR2

761

Q5VWN6
VSPLQRIYSGVKTHI

ZNF766

146

Q5HY98
SILYVVPSRQKLTHV

TMEFF1

316

Q8IYR6
EKLRTLLYQEHVPTS

WNK2

1591

Q9Y3S1
IKHLPYTTRRDSVLQ

TMEM177

286

Q53S58
LSIPQITTKHRGLYT

PSG5

286

Q15238
VVLLQTSPYHVDSLL

TCF25

276

Q9BQ70
RVAYAPKDLIISISH

SIGLEC11

246

Q96RL6
KLTRHRVTYVPLLGS

TERT

1081

O14746
ETAPRLVYTQHRKSV

WDR81

1686

Q562E7
VIHPYSRKAAQITRE

TMA16

16

Q96EY4
LQTKLYTLPASHATR

TSC2

571

P49815
ADKVTQLYVPASRHV

UBE3C

636

Q15386
LDLINHPTSYIRTKT

ZFP69

256

Q49AA0
TRLKIVTIHQEPFVY

GRIN1

396

Q05586