Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of neurogenesis

HDAC6 SMURF1 FXN SYNGAP1 PARP6 RNF6 ASCL1 FBXO31 ULK1 ARHGEF2 TNFRSF1B SPEN

4.81e-065159612GO:0050767
GeneOntologyBiologicalProcesscell morphogenesis

NRN1L ROCK2 CACNA1A HDAC6 ANK3 SMURF1 TRIOBP FXN SYNGAP1 PARP6 KIRREL3 MYO3A RNF6 ABI2 FBXO31 HRH2 ULK1 ARHGEF2

8.66e-0611949618GO:0000902
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

ROCK2 CACNA1A HDAC6 ANK3 SMURF1 TRIOBP FXN SYNGAP1 PARP6 MYO3A RNF6 ABI2 FBXO31 ULK1

9.18e-067489614GO:0048667
GeneOntologyBiologicalProcessneuron projection morphogenesis

NRN1L ROCK2 CACNA1A HDAC6 ANK3 SMURF1 FXN SYNGAP1 PARP6 KIRREL3 RNF6 ABI2 FBXO31 ULK1

2.00e-058029614GO:0048812
GeneOntologyBiologicalProcessneuron projection development

NRN1L ROCK2 CACNA1A HDAC6 ANK3 SMURF1 TRIOBP SPIRE1 FXN SYNGAP1 PARP6 KIRREL3 MYO3A PBRM1 RNF6 ABI2 FBXO31 ULK1

2.33e-0512859618GO:0031175
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

NRN1L ROCK2 CACNA1A HDAC6 ANK3 SMURF1 FXN SYNGAP1 PARP6 KIRREL3 RNF6 ABI2 FBXO31 ULK1

2.52e-058199614GO:0120039
GeneOntologyBiologicalProcessdendrite development

ROCK2 CACNA1A HDAC6 SPIRE1 SYNGAP1 PARP6 PBRM1 ABI2 FBXO31

2.65e-05335969GO:0016358
GeneOntologyBiologicalProcesscell projection morphogenesis

NRN1L ROCK2 CACNA1A HDAC6 ANK3 SMURF1 FXN SYNGAP1 PARP6 KIRREL3 RNF6 ABI2 FBXO31 ULK1

2.77e-058269614GO:0048858
GeneOntologyBiologicalProcessregulation of axonogenesis

CACNA1A HDAC6 SMURF1 FXN SYNGAP1 RNF6 ULK1

3.22e-05192967GO:0050770
GeneOntologyBiologicalProcessregulation of nervous system development

HDAC6 SMURF1 FXN SYNGAP1 PARP6 RNF6 ASCL1 FBXO31 ULK1 ARHGEF2 TNFRSF1B SPEN

3.30e-056259612GO:0051960
GeneOntologyBiologicalProcessneuron development

NRN1L ROCK2 CACNA1A HDAC6 ANK3 SMURF1 TRIOBP SPIRE1 FXN SYNGAP1 PARP6 KIRREL3 MYO3A PBRM1 RNF6 ABI2 ASCL1 FBXO31 ULK1

3.79e-0514639619GO:0048666
GeneOntologyBiologicalProcessregulation of cell development

ROCK2 HDAC6 SMURF1 KAT2A FXN SYNGAP1 PARP6 PBRM1 RNF6 ASCL1 FBXO31 ULK1 ARHGEF2 TNFRSF1B SPEN LILRA4

4.28e-0510959616GO:0060284
GeneOntologyBiologicalProcessmusculoskeletal movement, spinal reflex action

CACNA1A ASCL1

6.41e-053962GO:0050883
GeneOntologyBiologicalProcessvestibular nucleus development

CACNA1A ASCL1

6.41e-053962GO:0021750
GeneOntologyBiologicalProcessneuron migration

ADGRG1 KIRREL3 ABI2 ASCL1 FBXO31 ULK1 ARHGEF2

7.19e-05218967GO:0001764
GeneOntologyBiologicalProcessresponse to mitochondrial depolarisation

HDAC6 SMURF1 ULK1

1.62e-0423963GO:0098780
GeneOntologyBiologicalProcessnegative regulation of axonogenesis

HDAC6 SYNGAP1 RNF6 ULK1

2.00e-0462964GO:0050771
GeneOntologyBiologicalProcessmedulla oblongata development

CACNA1A ASCL1

2.12e-045962GO:0021550
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

HDAC6 SMURF1 FXN PARP6 ASCL1 FBXO31 TNFRSF1B SPEN

2.48e-04354968GO:0050769
GeneOntologyBiologicalProcessregulation of extent of cell growth

HDAC6 SMURF1 FXN RNF6 ULK1

2.65e-04122965GO:0061387
GeneOntologyBiologicalProcessdendrite morphogenesis

ROCK2 CACNA1A HDAC6 PARP6 ABI2 FBXO31

3.28e-04198966GO:0048813
GeneOntologyBiologicalProcessmitophagy

HDAC6 SMURF1 ABI2 ULK1

4.16e-0475964GO:0000423
GeneOntologyBiologicalProcessneuron projection extension

NRN1L HDAC6 SMURF1 FXN RNF6 ULK1

4.16e-04207966GO:1990138
GeneOntologyBiologicalProcessaxon extension

HDAC6 SMURF1 FXN RNF6 ULK1

4.23e-04135965GO:0048675
GeneOntologyBiologicalProcesstype 2 mitophagy

HDAC6 SMURF1

4.43e-047962GO:0061734
GeneOntologyBiologicalProcessregulation of anatomical structure morphogenesis

ROCK2 CACNA1A SP1 HDAC6 HIPK1 SMURF1 SPIRE1 FXN SYNGAP1 PARP6 RNF6 ABI2 FBXO31 ULK1

5.06e-0410909614GO:0022603
GeneOntologyCellularComponentsomatodendritic compartment

NCOA2 CACNA1A KIF21B CACNA1S PDE4B HDAC6 ANK3 SMURF1 CHRM5 SYNGAP1 KIRREL3 ABI2 ASCL1 FBXO31 HRH2 ULK1 ARHGEF2 TNFRSF1B

1.06e-0512289618GO:0036477
GeneOntologyCellularComponentdendrite

NCOA2 CACNA1A KIF21B CACNA1S PDE4B HDAC6 ANK3 CHRM5 SYNGAP1 KIRREL3 ABI2 HRH2 ARHGEF2

1.48e-048589613GO:0030425
GeneOntologyCellularComponentdendritic tree

NCOA2 CACNA1A KIF21B CACNA1S PDE4B HDAC6 ANK3 CHRM5 SYNGAP1 KIRREL3 ABI2 HRH2 ARHGEF2

1.52e-048609613GO:0097447
GeneOntologyCellularComponentcentrosome

ROCK2 PDE4B HDAC6 RBBP6 HIPK1 UBXN6 TRIOBP SORBS1 KAT2A CDC14B MTUS1 FBXO31

2.10e-047709612GO:0005813
GeneOntologyCellularComponentpostsynapse

NCOA2 ROCK2 CACNA1A KIF21B CACNA1S PDE4B ANK3 CHRM5 SYNGAP1 ABI2 PLEKHA5 ARHGEF2 RAB4A

7.60e-0410189613GO:0098794
DomainPH

ROCK2 TRIOBP SYNGAP1 PLEKHM2 PLEKHA5 ARHGEF2 AGAP1

1.38e-04229927PF00169
DomainSPOC_C

DIDO1 SPEN

3.55e-046922IPR012921
DomainSPOC

DIDO1 SPEN

3.55e-046922PF07744
DomainPH

ROCK2 TRIOBP SYNGAP1 PLEKHM2 PLEKHA5 ARHGEF2 AGAP1

4.47e-04278927SM00233
DomainPH_DOMAIN

ROCK2 TRIOBP SYNGAP1 PLEKHM2 PLEKHA5 ARHGEF2 AGAP1

4.57e-04279927PS50003
DomainPH_domain

ROCK2 TRIOBP SYNGAP1 PLEKHM2 PLEKHA5 ARHGEF2 AGAP1

4.67e-04280927IPR001849
DomainVDCC_a1su_IQ

CACNA1A CACNA1S

4.96e-047922IPR014873
DomainGPHH

CACNA1A CACNA1S

4.96e-047922PF16905
DomainGPHH_dom

CACNA1A CACNA1S

4.96e-047922IPR031649
DomainCa_chan_IQ

CACNA1A CACNA1S

4.96e-047922SM01062
DomainCa_chan_IQ

CACNA1A CACNA1S

4.96e-047922PF08763
DomainVDCCAlpha1

CACNA1A CACNA1S

1.05e-0310922IPR002077
Domain-

HDAC6 RBBP6 EXPH5 SPIRE1 DIDO1 NSD3 PHF2 RNF6

1.67e-034499283.30.40.10
DomainZnf_RING/FYVE/PHD

HDAC6 RBBP6 EXPH5 SPIRE1 DIDO1 NSD3 PHF2 RNF6

1.92e-03459928IPR013083
Domain-

ROCK2 TRIOBP SYNGAP1 PLEKHM2 PLEKHA5 ARHGEF2 AGAP1

3.18e-033919272.30.29.30
DomainRUN

SNX29 PLEKHM2

3.49e-0318922SM00593
DomainRUN

SNX29 PLEKHM2

3.89e-0319922PS50826
DomainRUN

SNX29 PLEKHM2

3.89e-0319922PF02759
DomainRun_dom

SNX29 PLEKHM2

3.89e-0319922IPR004012
DomainZinc_finger_PHD-type_CS

DIDO1 NSD3 PHF2

4.05e-0365923IPR019786
DomainPH_dom-like

ROCK2 TRIOBP SYNGAP1 PLEKHM2 PLEKHA5 ARHGEF2 AGAP1

5.08e-03426927IPR011993
DomainTNFR_c6

TNFRSF10B TNFRSF1B

5.20e-0322922PF00020
DomainZnf_FYVE_PHD

SPIRE1 DIDO1 NSD3 PHF2

6.03e-03147924IPR011011
DomainPHD

DIDO1 NSD3 PHF2

6.05e-0375923PF00628
DomainZnf_PHD-finger

DIDO1 NSD3 PHF2

6.98e-0379923IPR019787
DomainTNFR

TNFRSF10B TNFRSF1B

7.22e-0326922SM00208
DomainBromodomain_CS

KAT2A PBRM1

7.22e-0326922IPR018359
DomainDEATH

ANK3 TNFRSF10B

7.78e-0327922SM00005
DomainTNFR_NGFR_1

TNFRSF10B TNFRSF1B

8.94e-0329922PS00652
DomainTNFR_NGFR_2

TNFRSF10B TNFRSF1B

8.94e-0329922PS50050
DomainPHD

DIDO1 NSD3 PHF2

9.68e-0389923SM00249
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

SUPT20H RBBP6 MRM1 POLR2C TRIOBP ADGRG1 SPIRE1 DIDO1 ICE1 KAT2A NSD3 PHF2 LARP4B PBRM1 ABI2 SUPT6H TNRC6A ARHGEF2 EIF4G3 SPEN AGAP1

9.49e-101497982131527615
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

ROCK2 SP1 HDAC6 RBBP6 DIDO1 ANKLE2 LARP4B PBRM1 PLEKHA5 ARHGEF2 EIF4G3 SRRM2 SPEN

1.82e-09503981316964243
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NCOA2 ROCK2 CACNA1A KIF21B PDE4B ANK3 TRIOBP DIDO1 SORBS1 SYNGAP1 PBRM1 ABI2 NISCH PLEKHA5 ARHGEF2 UNC79

1.20e-08963981628671696
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZBTB2 SUPT20H HDAC6 RBBP6 POLR2C KAT2A TNFRSF10B SCEL NSD3 PHF2 LARP4B INTS14 PBRM1 MTUS1 TNRC6A CRNN SRRM2

1.42e-081116981731753913
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

PRUNE2 CACNA1S SP1 AFF2 ANK3 RBBP6 SYNGAP1 LARP4B USF3 EIF4G3 SPEN

3.88e-08430981135044719
Pubmed

A human MAP kinase interactome.

SP1 SUPT20H ANK3 RBBP6 EXPH5 HIPK1 SORBS1 NSD3 USF3 TNRC6A PLEKHA5

1.33e-07486981120936779
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KIF21B TRIOBP SPIRE1 DIDO1 ICE1 ANKLE2 MTUS1 SUPT6H TNRC6A PLEKHA5 AGAP1

3.09e-07529981114621295
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ROCK2 EXPH5 HIPK1 ANKLE2 PHF2 ARHGEF2

4.64e-071029869734811
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

MCM7 NSD3 PHF2 PBRM1 ARHGEF2 SPEN

6.87e-0710998633554859
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SUPT20H HDAC6 RBBP6 POLR2C SMURF1 TRIOBP DIDO1 NSD3 SYNGAP1 PHF2 SUPT6H ARHGEF2 SRRM2 SPEN

2.10e-061082981438697112
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

HIPK1 SMURF1 SORBS1 KIRREL3 PLEKHM2 NISCH ULK1 SRRM2 SPEN

2.37e-0640798912693553
Pubmed

Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.

RBBP6 UBXN6 TRIOBP SORBS1 ABI2 LNPK

3.35e-0614398632560809
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

NCOA2 SUPT20H RBBP6 HIPK1 POLR2C MCM7 SORBS1 SUPT6H TNRC6A SPEN

6.53e-06588981038580884
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

CACNA1A HIPK1 SORBS1 SYNGAP1 LNPK ARHGEF2 EIF4G3 SRRM2

6.53e-0634798817114649
Pubmed

Hypokalaemic periodic paralysis due to the CACNA1S R1239H mutation in a large African family.

CACNA1A CACNA1S

7.86e-06298217418573
Pubmed

Deletion of Ulk1 inhibits neointima formation by enhancing KAT2A/GCN5-mediated acetylation of TUBA/α-tubulin in vivo.

KAT2A ULK1

7.86e-06298233985412
Pubmed

Dido3-dependent HDAC6 targeting controls cilium size.

HDAC6 DIDO1

7.86e-06298224667272
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ANK3 ZNF174 POLR2C TRIOBP ANKLE2 CDC14B NSD3 PHF2 MTUS1 ABI2 TNRC6A ARHGEF2 SRRM2

7.98e-061049981327880917
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NCOA2 PDE4B HDAC6 ANK3 POLG SMURF1 SPIRE1 DIDO1 ANKLE2 LARP4B INTS14 LNPK SZRD1

1.13e-051084981311544199
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NCOA2 SUPT20H HDAC6 ANK3 HIPK1 POLG POLR2C TRIOBP SORBS1 SYNGAP1 ASCL1 NISCH EIF4G3 AGAP1

1.48e-051285981435914814
Pubmed

DNA cloning using in vitro site-specific recombination.

UBL3 TRIOBP SORBS1 EPX MRPL18 INTS14 FBXO31 ULK1 ARHGEF2 RAB4A CAPN15

1.51e-05794981111076863
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NCOA2 PRUNE2 ANK3 POLG SMURF1 TRIOBP ADGRG1 SPIRE1 CDC14B SNX29 PHF2 USF3 SUPT6H EIF4G3 AGAP1

1.79e-051489981528611215
Pubmed

TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors.

SP1 ASCL1

2.35e-05398220599619
Pubmed

Relation of ADRB3, GEF, ROCK2 gene polymorphisms to clinical findings in overactive bladder.

ROCK2 ARHGEF2

2.35e-05398231802204
Pubmed

Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1.

SP1 TNFRSF10B

2.35e-05398214561739
Pubmed

Piceatannol enhances TRAIL-induced apoptosis in human leukemia THP-1 cells through Sp1- and ERK-dependent DR5 up-regulation.

SP1 TNFRSF10B

2.35e-05398221167276
Pubmed

Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy.

PDE4B TNFRSF1B

2.35e-05398229752424
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ROCK2 ANK3 TRIOBP ANKLE2 ABI2 NISCH PLEKHA5 AGAP1

2.63e-0542198836976175
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

NCOA2 ROCK2 AFF2 RBBP6 EXPH5 SPEN

2.84e-0520898633230847
Pubmed

The Repeat Expansion Diseases: The dark side of DNA repair.

CACNA1A AFF2 FXN

3.69e-052398326002199
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

SP1 HDAC6 AFF2 PCDHA12 EPX LTBP2 SPEN

4.21e-0532998717474147
Pubmed

Novel transcription factors in human CD34 antigen-positive hematopoietic cells.

SUPT20H DIDO1

4.70e-05498212070015
Pubmed

DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells.

KAT2A TNFRSF10B

4.70e-05498225770212
Pubmed

Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries.

ANK3 PBRM1

4.70e-05498221037240
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

NCOA2 CACNA1A SP1 HIPK1 PLEKHM2 SRRM2

5.34e-0523398637704626
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

RBBP6 MCM7 LARP4B PBRM1 SUPT6H TNRC6A SPEN UNC79

5.62e-0546998827634302
Pubmed

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.

HDAC6 RBBP6 LARP4B MTUS1 ARHGEF2

6.86e-0515098522678362
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SP1 SUPT20H RBBP6 POLR2C DIDO1 KAT2A NSD3 PHF2 INTS14 PBRM1 SUPT6H SRRM2 SPEN

7.04e-051294981330804502
Pubmed

RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.

PBRM1 EIF4G3 SRRM2

7.52e-052998336800290
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

ANK3 RBBP6 DIDO1 ICE1 PLEKHA5 SRRM2 SPEN

7.54e-0536198726167880
Pubmed

RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product.

SP1 POLR2C

7.82e-05598216141233
Pubmed

ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65.

SP1 ZBTB2

7.82e-05598225609694
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ROCK2 PRUNE2 ZBTB2 EXPH5 PHF2 LARP4B USF3 LNPK

7.95e-0549398815368895
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

MCM7 ANKLE2 PBRM1 SUPT6H ARMC5 TNRC6A PLEKHA5 ARHGEF2 SRRM2

8.30e-0563998923443559
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

KIF21B SUPT20H ANK3 EXPH5 MRM1 SORBS1 SYNGAP1 PLEKHA5

8.40e-0549798836774506
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

CACNA1A UBE2J1 ANK3 TRIOBP SORBS1 ANKLE2 SYNGAP1 LARP4B ABI2 TNRC6A LNPK EIF4G3

8.75e-051139981236417873
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

ROCK2 RBBP6 MRM1 DIDO1 LARP4B SUPT6H TNRC6A EIF4G3 SRRM2 SPEN

9.53e-05807981022681889
Pubmed

Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.

NCOA2 ZBTB2 RBBP6 SRRM2

1.01e-048598416051665
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

CACNA1S LARP4B PBRM1

1.11e-043398322357600
Pubmed

ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.

ROCK2 SMURF1

1.17e-04698228049720
Pubmed

USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy.

HDAC6 ULK1

1.17e-04698230335599
Pubmed

Role of Unc51.1 and its binding partners in CNS axon outgrowth.

SYNGAP1 ULK1

1.17e-04698215014045
Pubmed

Akhirin regulates the proliferation and differentiation of neural stem cells/progenitor cells at neurogenic niches in mouse brain.

VIT ASCL1

1.17e-04698231943155
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

UBL3 SORBS1 LARP4B TNRC6A PLEKHA5 ARHGEF2 SZRD1 AGAP1

1.41e-0453698815840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

UBL3 SORBS1 LARP4B TNRC6A PLEKHA5 ARHGEF2 SZRD1 AGAP1

1.45e-0453898810512203
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

SUPT20H RBBP6 DIDO1 KAT2A LARP4B PBRM1

1.49e-0428198624163370
Pubmed

Mast cell-derived histamine mediates cystitis pain.

HRH2 TNFRSF1B

1.64e-04798218461160
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

NCOA2 ANK3 RBBP6 DIDO1 MCM7 NSD3 PLEKHA5 SPEN

1.66e-0454998838280479
Pubmed

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.

RBBP6 FXN LARP4B MRPL18 SUPT6H NISCH ARHGEF2

1.89e-0441998733001583
Pubmed

Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.

SORBS1 RNF6

2.18e-04898222905720
Pubmed

Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression.

SP1 HDAC6

2.18e-04898216288017
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

RBBP6 MCM7 PBRM1 RNF6 SPEN

2.34e-0419598519454010
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

POLR2C MCM7 LARP4B PBRM1 SUPT6H NISCH ARHGEF2

2.54e-0444098734244565
Pubmed

ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct.

SUPT20H POLR2C KAT2A

2.64e-044498337682711
Pubmed

Functional proteomics mapping of a human signaling pathway.

ANK3 RBBP6 EXPH5 HIPK1 SMURF1 FAM161B ANKLE2 PBRM1

2.73e-0459198815231748
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1S

2.79e-04998216382099
Pubmed

Genome wide association study of age at menarche in the Japanese population.

KIRREL3 AGAP1

2.79e-04998223667675
Pubmed

UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair.

HDAC6 KAT2A

2.79e-04998228854355
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

POLG SPIRE1 ICE1 KAT2A CDC14B NSD3 PLEKHM2 NISCH ULK1 ARHGEF2 SPEN

2.85e-041105981135748872
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

ROCK2 ANK3 SPIRE1 MCM7 ANKLE2 NISCH DACT3 CRNN AGMAT PLEKHA5 LNPK AGAP1

3.43e-041321981227173435
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ROCK2 SP1 HDAC6 RBBP6 DIDO1 MYO3A ARHGEF2 SRRM2 SPEN

3.45e-0477498915302935
Pubmed

A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP.

NCOA2 KAT2A

3.48e-041098211964378
Pubmed

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.

CHRM5 AGAP1

3.48e-041098220664521
Pubmed

The genetic aetiology of late-onset chronic progressive cerebellar ataxia. A population-based study.

CACNA1A FXN

3.48e-041098219259763
Pubmed

Graft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant.

TNFRSF10B TNFRSF1B

3.48e-041098221768400
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

SORBS1 SYNGAP1 TNRC6A ARHGEF2 AGAP1

3.91e-0421898533378226
Pubmed

De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.

POLR2C SUPT6H

4.25e-041198231045206
Pubmed

Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.

SUPT20H KAT2A

4.25e-041198224051374
Pubmed

Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation.

NCOA2 KAT2A

4.25e-041198216109736
Pubmed

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.

MCM7 SUPT6H

5.09e-041298230479348
Pubmed

Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.

TNFRSF10B TNFRSF1B

5.09e-041298229436413
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

HDAC6 RBBP6 POLR2C LARP4B SUPT6H SRRM2

5.42e-0435898632460013
Pubmed

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

MTUS1 PLEKHA5 ARHGEF2

5.68e-045798329089450
Pubmed

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.

POLR2C PHF2 SUPT6H

6.29e-045998334108663
Pubmed

Human transcription factor protein interaction networks.

NCOA2 SP1 SUPT20H RBBP6 DIDO1 KAT2A PHF2 LARP4B PBRM1 TNRC6A SRRM2 SPEN

6.88e-041429981235140242
Pubmed

Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.

TRIOBP MYO3A

7.00e-041498226754646
Pubmed

Control of HIV latency by epigenetic and non-epigenetic mechanisms.

SP1 POLR2C

7.00e-041498222211660
Pubmed

Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation.

PDE4B KIRREL3

7.00e-041498219519663
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

ROCK2 ANK3 TNFRSF10B ABI2 PLEKHA5 AGAP1

7.10e-0437798638117590
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NCOA2 ZBTB2 HDAC6 HIPK1 MRPL18 ABI2 NISCH ARHGEF2 SPEN

7.16e-0485798925609649
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

EXPH5 SPIRE1 SORBS1 NSD3 MTUS1 PLEKHA5 ARHGEF2 EIF4G3 SRRM2

7.40e-0486198936931259
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

ANK3 TRIOBP SNX29 PLEKHA5 ARHGEF2

7.40e-0425198529778605
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

ROCK2 PDE4B ANK3 SORBS1 SYNGAP1

7.40e-0425198527507650
Pubmed

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.

MCM7 LARP4B MRPL18 PBRM1 SUPT6H

7.67e-0425398529911972
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1A CACNA1S

8.06e-041598220188150
Pubmed

The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB.

SP1 POLR2C

8.06e-04159828800208
Pubmed

TRIM28 functions as the SUMO E3 ligase for PCNA in prevention of transcription induced DNA breaks.

POLR2C MCM7

8.06e-041598232900933
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1A CACNA1S

8.06e-041598224453333
Pubmed

HIV latency.

SP1 POLR2C

8.06e-041598222229121
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

ROCK2 UBE2J1 HDAC6 ANK3 THSD1 ANKLE2 PLEKHA5 EIF4G3

8.93e-0470898839231216
InteractionH3-4 interactions

NCOA2 SUPT20H DIDO1 MCM7 KAT2A NSD3 PHF2 USF3 PBRM1 TNRC6A PLEKHA5 RAB4A

1.16e-064489412int:H3-4
InteractionTWIST1 interactions

HDAC6 MCM7 NSD3 PHF2 PBRM1 ARHGEF2 SPEN

1.48e-05170947int:TWIST1
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ROCK2 TRIOBP PLEKHM2 PLEKHA5 ARHGEF2 AGAP1

8.80e-05206646682
GeneFamilyLysine acetyltransferases|ATAC complex|SAGA complex|GCN5 related N-acetyltransferases

SUPT20H KAT2A

1.62e-03176421059
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

NCOA2 KAT2A

1.62e-0317642486
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN

ROCK2 KIF21B POLG ADGRG1 DIDO1 MCM7 KAT2A TNFRSF10B SNX29 CD300C PLEKHM2 STRADA NISCH ULK1 TNFRSF1B SRRM2 SPEN

3.43e-089059717M40865
CoexpressionGSE7568_CTRL_VS_3H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_DN

ROCK2 PDE4B HIPK1 ANKLE2 PARP6 PHF2 NISCH TNRC6A

2.05e-07167978M361
CoexpressionGSE6092_IFNG_VS_IFNG_AND_B_BURGDORFERI_INF_ENDOTHELIAL_CELL_UP

KIF21B HIPK1 MCM7 SNX29 CD300C PLEKHM2 EIF4G3

4.89e-06180977M6718
CoexpressionGSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_UP

ZBTB2 PDE4B UBL3 SMURF1 USF3 TNRC6A SPEN

7.47e-06192977M8272
CoexpressionLAKE_ADULT_KIDNEY_C3_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S1_S2

PRUNE2 ANK3 SNX29 TNRC6A PLEKHA5 SRRM2 AGAP1

1.86e-05221977M39222
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 ANK3 ADGRG1 SNX29 PLEKHA5 AGAP1

4.12e-061919863c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 ANK3 ADGRG1 SNX29 PLEKHA5 AGAP1

4.12e-061919861c1d13144259b998d4a0e85142f7afef2ef1e63f
Drugprazosin hydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A_EA

SP1 SUPT20H ANK3 ZNF174 MRM1 KAT2A RNF6 PLEKHM2 SZRD1

1.40e-07197959826_DN
DrugHydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; PC3; HT_HG-U133A

NCOA2 ROCK2 SP1 MRM1 POLG LARP4B RNF6 LTBP2

1.55e-061949585075_DN
DrugFoliosidine [2520-38-9]; Down 200; 13uM; MCF7; HT_HG-U133A

AFF2 MRM1 POLG POLR2C TRIOBP CDC14B NSD3 EIF4G3

1.74e-061979584761_DN
Drug9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A

NCOA2 ROCK2 UBE2J1 EXPH5 POLR2C ADGRG1 THSD1 NSD3

1.81e-061989587500_DN
Druggeldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A

NCOA2 UBE2J1 AFF2 SORBS1 MRPL18 LTBP2 ARHGEF2

1.18e-051839576946_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

MRM1 TRIOBP KAT2A NSD3 SUPT6H AGMAT CAPN15

1.66e-051939571284_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; SKMEL5; HG-U133A

UBE2J1 PDE4B HDAC6 UBL3 RBBP6 MRM1 POLG

1.66e-05193957629_DN
DrugAcenocoumarol [152-72-7]; Down 200; 11.4uM; MCF7; HT_HG-U133A

HDAC6 EXPH5 KAT2A TNFRSF10B SUPT6H SZRD1 CAPN15

1.66e-051939577232_DN
DrugICI182,780; Down 200; 1uM; PC3; HT_HG-U133A

SUPT20H ANK3 ZNF174 POLG CHRM5 NSD3 RNF6

1.78e-051959577539_DN
DrugIoxaglic acid [59017-64-0]; Down 200; 3.2uM; HL60; HT_HG-U133A

SP1 POLR2C KAT2A NSD3 RNF6 AGMAT EIF4G3

1.78e-051959572966_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

NCOA2 SP1 POLR2C SMURF1 EPX LARP4B AGMAT

1.78e-051959572208_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A_EA

NCOA2 ROCK2 TRIOBP TNFRSF10B LARP4B RNF6 PLEKHM2

1.78e-05195957989_DN
DrugHarmol hydrochloride monohydrate [40580-83-4]; Down 200; 15.8uM; PC3; HT_HG-U133A

UBE2J1 SUPT20H ANK3 ZNF174 HIPK1 TNFRSF10B ABI2

1.83e-051969577320_DN
DrugNiridazole [61-57-4]; Up 200; 18.6uM; HL60; HT_HG-U133A

SP1 MRM1 SMURF1 CDC14B LARP4B PLEKHM2 LTBP2

1.83e-051969572440_UP
DrugAcenocoumarol [152-72-7]; Down 200; 11.4uM; HL60; HG-U133A

RBBP6 MRM1 POLR2C TRIOBP PLEKHM2 EIF4G3 SZRD1

1.90e-051979571394_DN
DrugDebrisoquin sulfate [581-88-4]; Up 200; 9uM; HL60; HG-U133A

ROCK2 UBE2J1 ANK3 MRM1 POLG ABI2 SZRD1

1.90e-051979571591_UP
DrugTetrahydroxy-1,4-quinone monohydrate [319-89-1]; Down 200; 21uM; MCF7; HT_HG-U133A

ROCK2 EXPH5 KAT2A CDC14B NSD3 RNF6 PLEKHM2

1.90e-051979573338_DN
DrugDelsoline [509-18-2]; Up 200; 8.6uM; HL60; HT_HG-U133A

ROCK2 CACNA1A SMURF1 THSD1 ST7L CDC14B CRNN

1.90e-051979572513_UP
Drug2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A

HDAC6 ZNF174 POLG DIDO1 LARP4B SUPT6H CAPN15

1.90e-051979576974_DN
DrugTomatidine [77-59-8]; Down 200; 9.6uM; MCF7; HT_HG-U133A

ROCK2 HDAC6 POLR2C MTUS1 SUPT6H SRRM2 CAPN15

1.96e-051989577166_DN
Drug5140203; Up 200; 15uM; MCF7; HT_HG-U133A_EA

NCOA2 ROCK2 ANK3 EXPH5 LARP4B RNF6 ARHGEF2

1.96e-05198957908_UP
DrugGabazine [105538-73-6]; Down 200; 10.8uM; HL60; HT_HG-U133A

UBL3 EXPH5 POLG TRIOBP TNFRSF10B PLEKHM2 PLEKHA5

1.96e-051989571316_DN
DrugSulfamonomethoxine [1220-83-3]; Down 200; 14.2uM; MCF7; HT_HG-U133A

NCOA2 AFF2 EXPH5 POLR2C SMURF1 MTUS1 SRRM2

1.96e-051989577200_DN
DrugClorgyline hydrochloride [17780-75-5]; Down 200; 13uM; MCF7; HT_HG-U133A

HDAC6 ZNF174 POLR2C TNFRSF10B LARP4B RNF6 SUPT6H

1.96e-051989573219_DN
DrugSulfamethoxypyridazine [80-35-3]; Down 200; 14.2uM; MCF7; HT_HG-U133A

NCOA2 ROCK2 ZNF174 POLG POLR2C THSD1 ARHGEF2

1.96e-051989574733_DN
DrugAC1L1JG6

ROCK2 CACNA1A CACNA1S

2.48e-0514953CID000005026
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

NCOA2 PHF2 LARP4B RNF6 SRRM2 CAPN15

6.52e-051649564388_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SMURF1 TRIOBP DIDO1 PHF2 INTS14 SRRM2

9.05e-051749563993_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NCOA2 UBE2J1 TRIOBP PHF2 INTS14 SRRM2

9.34e-051759567387_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

NCOA2 MRM1 POLG DIDO1 PHF2 SRRM2

9.64e-051769562639_DN
Drug(-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; HL60; HT_HG-U133A

KIF21B UBE2J1 MRM1 POLR2C KAT2A AGMAT

1.03e-041789562977_DN
DrugEtifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT_HG-U133A

RBBP6 EXPH5 CDC14B SRRM2 SPEN SZRD1

1.03e-041789563998_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

NCOA2 MRM1 DIDO1 KAT2A PHF2 SRRM2

1.03e-041789564710_DN
Drugtrichostatin A; Down 200; 0.1uM; MCF7; HG-U133A

POLG ADGRG1 PHF2 PLEKHM2 ASCL1 CAPN15

1.06e-04179956332_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NCOA2 UBE2J1 TRIOBP PHF2 INTS14 SRRM2

1.06e-041799564483_DN
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; PC3; HT_HG-U133A

NCOA2 RBBP6 EXPH5 TRIOBP PLEKHA5 EIF4G3

1.12e-041819561791_DN
Drugirinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A

NCOA2 ROCK2 DIDO1 LARP4B PLEKHA5 AGAP1

1.19e-041839567498_DN
DrugSulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A

EXPH5 HIPK1 TNFRSF10B LARP4B SRRM2 SPEN

1.27e-041859561673_DN
DrugEthaverine hydrochloride [985-13-7]; Up 200; 9.2uM; HL60; HT_HG-U133A

PDE4B EPX RNF6 MTUS1 ASCL1 CRNN

1.34e-041879563037_UP
DrugTolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A

ZNF174 HIPK1 UBXN6 ADGRG1 LTBP2 SRRM2

1.47e-041909564362_DN
DrugFenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A

NCOA2 EXPH5 HIPK1 THSD1 CDC14B NSD3

1.51e-041919564279_DN
Drug17-AAG; Down 200; 1uM; HL60; HT_HG-U133A

KIF21B UBE2J1 EXPH5 MRM1 POLR2C PLEKHM2

1.51e-041919562685_DN
DrugEconazole nitrate [24169-02-6]; Down 200; 9uM; MCF7; HT_HG-U133A

UBE2J1 POLG TRIOBP CDC14B LARP4B SRRM2

1.55e-041929567427_DN
DrugSulfadiazine [68-35-9]; Down 200; 16uM; HL60; HT_HG-U133A

ROCK2 MRM1 POLG POLR2C TNFRSF10B RNF6

1.60e-041939561852_DN
DrugNomifensine maleate [32795-47-4]; Down 200; 11.2uM; HL60; HG-U133A

ROCK2 POLR2C UBXN6 EPX ABI2 SZRD1

1.60e-041939561378_DN
DrugNaltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; HL60; HG-U133A

ROCK2 HIPK1 MRM1 ABI2 SZRD1 CAPN15

1.60e-041939561363_DN
Drugrapamycin, Streptomyces hygroscepicus; Up 200; 0.1uM; PC3; HT_HG-U133A

ROCK2 SUPT20H DIDO1 TNFRSF10B SCEL ULK1

1.60e-041939565932_UP
DrugClemastine fumarate [14976-57-9]; Up 200; 8.6uM; HL60; HT_HG-U133A

ROCK2 PDE4B ANK3 LARP4B LTBP2 SRRM2

1.60e-041939562412_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

NCOA2 ROCK2 CACNA1A POLG NSD3 AGMAT

1.60e-041939562721_DN
DrugIopromide [73334-07-3]; Up 200; 5uM; MCF7; HT_HG-U133A

NCOA2 SUPT20H EXPH5 NSD3 ARHGEF2 SZRD1

1.64e-041949563481_UP
Drugretinoic acid; Down 200; 1uM; PC3; HT_HG-U133A

PDE4B SMURF1 TNFRSF10B THSD1 SUPT6H SRRM2

1.64e-041949561211_DN
DrugDiphenidol hydrochloride [3254-89-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A

ROCK2 UBE2J1 SUPT20H ZNF174 SUPT6H EIF4G3

1.64e-041949567406_DN
Drugnordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A_EA

UBE2J1 ZNF174 DIDO1 TNFRSF10B CDC14B NSD3

1.64e-041949561061_UP
Drugalpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA

UBE2J1 HDAC6 TRIOBP DIDO1 CDC14B SRRM2

1.64e-04194956990_DN
DrugBiotin [58-85-5]; Down 200; 16.4uM; PC3; HT_HG-U133A

CACNA1A AFF2 SMURF1 TRIOBP CDC14B LARP4B

1.69e-041959566689_DN
DrugChelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; PC3; HT_HG-U133A

SUPT20H RBBP6 SORBS1 NSD3 MYO3A EIF4G3

1.69e-041959565760_UP
DrugPargyline hydrochloride [306-07-0]; Down 200; 20.4uM; PC3; HT_HG-U133A

ANK3 SCEL MTUS1 NISCH SZRD1 CAPN15

1.69e-041959562102_DN
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A

SP1 EXPH5 MTUS1 ABI2 PLEKHA5 SRRM2

1.69e-041959562566_UP
DrugOxprenolol hydrochloride [6452-73-9]; Down 200; 13.2uM; MCF7; HT_HG-U133A

NCOA2 HDAC6 EXPH5 PHF2 ULK1 EIF4G3

1.69e-041959567225_DN
DrugSTOCK1N-35874; Up 200; 14uM; PC3; HT_HG-U133A

ZNF174 HIPK1 SMURF1 TNFRSF10B CDC14B SRRM2

1.69e-041959566561_UP
DrugMycophenolic acid [24280-93-1]; Down 200; 12.4uM; PC3; HT_HG-U133A

AFF2 POLR2C SMURF1 NSD3 SRRM2 CAPN15

1.69e-041959564019_DN
DrugEthionamide [536-33-4]; Up 200; 24uM; PC3; HT_HG-U133A

SUPT20H POLR2C EPX NSD3 RNF6 ARHGEF2

1.69e-041959564593_UP
DrugDiphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

ROCK2 MRM1 TRIOBP RNF6 SUPT6H SZRD1

1.74e-041969561708_DN
DrugLoxapine succinate [27833-64-3]; Down 200; 9uM; MCF7; HT_HG-U133A

ANK3 MRM1 POLR2C TRIOBP KAT2A SUPT6H

1.74e-041969565293_DN
DrugDiltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; PC3; HG-U133A

NCOA2 HIPK1 CDC14B AGMAT PLEKHA5 SPEN

1.74e-041969561948_DN
DrugPrilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A

AFF2 POLR2C UBXN6 CDC14B NSD3 EIF4G3

1.74e-041969564749_DN
DrugFoliosidine [2520-38-9]; Down 200; 13uM; PC3; HT_HG-U133A

CACNA1A SP1 MRM1 POLR2C THSD1 NSD3

1.74e-041969563739_DN
DrugFlurandrenolide [1524-88-5]; Up 200; 9.2uM; PC3; HT_HG-U133A

CACNA1A SP1 SUPT20H ST7L CDC14B CD300C

1.74e-041969567378_UP
DrugLevonordefrin [829-74-3]; Up 200; 21.8uM; MCF7; HT_HG-U133A

NCOA2 ROCK2 UBE2J1 SORBS1 EPX LTBP2

1.74e-041969567208_UP
DrugTerazosin hydrochloride [63590-64-7]; Up 200; 9.4uM; HL60; HT_HG-U133A

NCOA2 ROCK2 HDAC6 SMURF1 ASCL1 SUPT6H

1.74e-041969562530_UP
Drug17-AAG; Up 200; 1uM; PC3; HT_HG-U133A

PDE4B HDAC6 AFF2 DIDO1 SORBS1 PARP6

1.74e-041969565919_UP
DrugGlafenine hydrochloride [65513-72-6]; Down 200; 9.8uM; PC3; HT_HG-U133A

NCOA2 ROCK2 UBE2J1 ANK3 LTBP2 EIF4G3

1.74e-041969567257_DN
DrugDiethylstilbestrol [56-53-1]; Up 200; 15uM; PC3; HT_HG-U133A

PRUNE2 PDE4B SORBS1 SCEL PARP6 RNF6

1.74e-041969564547_UP
DrugOxybenzone [131-57-7]; Down 200; 17.6uM; PC3; HT_HG-U133A

NCOA2 TNFRSF10B MTUS1 SUPT6H ULK1 CAPN15

1.74e-041969566309_DN
Drugestradiol; Up 200; 0.01uM; PC3; HT_HG-U133A

PDE4B POLR2C SORBS1 EPX PARP6 HRH2

1.74e-041969565910_UP
DrugSuramin sodium salt; Down 200; 10uM; MCF7; HT_HG-U133A

NCOA2 ROCK2 UBE2J1 TNFRSF10B SNX29 RNF6

1.74e-041969567496_DN
DrugPinacidil [85371-64-8]; Down 200; 16.4uM; HL60; HT_HG-U133A

TRIOBP NSD3 PLEKHM2 ABI2 SUPT6H CAPN15

1.74e-041969562406_DN
DrugSuxibuzone [27470-51-5]; Down 200; 9.2uM; PC3; HT_HG-U133A

HDAC6 ANK3 POLR2C CDC14B MTUS1 SZRD1

1.74e-041969565806_DN
DrugAlclometasone dipropionate [667634-13-2]; Down 200; 7.6uM; MCF7; HT_HG-U133A

UBXN6 DIDO1 TNFRSF10B LARP4B PBRM1 AGMAT

1.78e-041979566229_DN
DrugIfosfamide [3778-73-2]; Down 200; 15.4uM; MCF7; HT_HG-U133A

HDAC6 MRM1 SMURF1 KAT2A CDC14B SRRM2

1.78e-041979566279_DN
DrugTolbutamide [64-77-7]; Up 200; 14.8uM; PC3; HT_HG-U133A

SP1 ADGRG1 KAT2A CDC14B RNF6 MTUS1

1.78e-041979564540_UP
DrugFolic acid [59-30-3]; Down 200; 9uM; MCF7; HT_HG-U133A

ROCK2 ANK3 KAT2A CDC14B SZRD1 CAPN15

1.78e-041979567201_DN
DrugLevonordefrin [829-74-3]; Down 200; 21.8uM; MCF7; HT_HG-U133A

HDAC6 MRM1 KAT2A EIF4G3 SRRM2 CAPN15

1.78e-041979567208_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

DIDO1 MCM7 FXN RNF6 AGMAT LTBP2

1.78e-041979562375_DN
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

ROCK2 HIPK1 THSD1 LARP4B MTUS1 SUPT6H

1.78e-041979561183_DN
DrugMoxisylyte hydrochoride [964-52-3]; Down 200; 12.6uM; HL60; HT_HG-U133A

PDE4B ZNF174 MRM1 TRIOBP RNF6 CAPN15

1.78e-041979561846_DN
DrugAlprostadil [745-65-3]; Up 200; 11.2uM; MCF7; HT_HG-U133A

NCOA2 PRUNE2 AFF2 UBXN6 NSD3 PBRM1

1.78e-041979567358_UP
DrugIfenprodil tartrate [23210-58-4]; Down 200; 8.4uM; PC3; HT_HG-U133A

SP1 POLG TRIOBP THSD1 MTUS1 LTBP2

1.78e-041979565044_DN
DrugNicardipine hydrochloride [54527-84-3]; Down 200; 7.8uM; HL60; HG-U133A

ROCK2 UBE2J1 SUPT20H POLR2C NSD3 PLEKHM2

1.78e-041979561600_DN
DrugICI182,780; Down 200; 1uM; PC3; HT_HG-U133A

ROCK2 AFF2 POLR2C CD300C NSD3 PARP6

1.78e-041979566867_DN
DrugBezafibrate [41859-67-0]; Up 200; 11uM; PC3; HT_HG-U133A

CACNA1A AFF2 SNX29 CD300C PLEKHM2 ASCL1

1.78e-041979566653_UP
DrugCiprofloxacin hydrochloride [93107-08-5]; Down 200; 10.8uM; HL60; HG-U133A

PDE4B MRM1 POLR2C DIDO1 TNFRSF10B SZRD1

1.78e-041979562022_DN
Drug2-propylpentanoic acid; Down 200; 500uM; PC3; HT_HG-U133A

UBE2J1 PDE4B POLR2C PHF2 PLEKHM2 SRRM2

1.78e-041979561240_DN
DrugClemastine fumarate [14976-57-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A

UBE2J1 ZNF174 POLR2C TRIOBP TNFRSF10B NSD3

1.83e-041989567443_DN
Drugtroglitazone; Down 200; 10uM; MCF7; HT_HG-U133A

SP1 POLR2C CDC14B LARP4B PLEKHM2 CAPN15

1.83e-041989566991_DN
DrugNalidixic acid sodium salt hydrate; Down 200; 14.6uM; MCF7; HT_HG-U133A

SP1 ZNF174 THSD1 LARP4B RNF6 PLEKHM2

1.83e-041989562297_DN
DrugAmyleine hydrochloride [532-59-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A

NCOA2 SP1 ZNF174 POLR2C SMURF1 INTS14

1.83e-041989561491_DN
DrugDicyclomine hydrochloride [67-92-5]; Up 200; 11.6uM; HL60; HG-U133A

POLG DIDO1 THSD1 CD300C NSD3 SUPT6H

1.83e-041989561983_UP
DrugMecamylamine hydrochloride [826-39-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A

ZNF174 POLR2C CDC14B LARP4B RNF6 EIF4G3

1.83e-041989567023_DN
DrugBacitracin [1405-87-4]; Up 200; 2.8uM; HL60; HT_HG-U133A

ANK3 EXPH5 SMURF1 ST7L EPX CDC14B

1.83e-041989563109_UP
Diseaseskin conductance response frequency, electrodermal activity measurement

RBBP6 TNRC6A

3.20e-053972EFO_0006866, EFO_0006869
Diseaseelectrodermal activity measurement

RBBP6 TNRC6A

3.20e-053972EFO_0006866
Diseasethrombospondin type-1 domain-containing protein 1 measurement

THSD1 KIRREL3

1.06e-045972EFO_0802131
DiseaseEsophageal carcinoma

RNF6 CRNN

2.22e-047972C0152018
DiseaseWithdrawal Symptoms

SMURF1 CHRM5 HRH2

9.32e-0458973C0087169
DiseaseDrug Withdrawal Symptoms

SMURF1 CHRM5 HRH2

9.32e-0458973C0086189
DiseaseSubstance Withdrawal Syndrome

SMURF1 CHRM5 HRH2

9.32e-0458973C0038587
DiseaseNonorganic psychosis

SP1 ANK3 PBRM1

1.54e-0369973C0349204
Diseaseage at first sexual intercourse measurement

PDE4B SNX29 PHF2 TNRC6A PLEKHA5 UNC79

1.68e-03383976EFO_0009749
Diseaseage at onset, smoking initiation

NCOA2 SCEL

1.76e-0319972EFO_0004847, EFO_0005670
Diseasered blood cell density measurement

NRN1L SP1 SORBS1 EPX LARP4B PBRM1 STRADA EIF4G3 AGAP1

2.47e-03880979EFO_0007978
Diseasethyroxine measurement

DIDO1 SNX29 KIRREL3

2.62e-0383973EFO_0005130
Diseaseneuroticism measurement, cognitive function measurement

PCDHA12 SNX29 SYNGAP1 TNRC6A LNPK EIF4G3 AGAP1

2.68e-03566977EFO_0007660, EFO_0008354
Diseasedepressive symptom measurement

CACNA1A PHF2 KIRREL3 ASCL1 LNPK EIF4G3

2.86e-03426976EFO_0007006
Diseaseresponse to venlafaxine

POLG AGAP1

3.05e-0325972EFO_0006328

Protein segments in the cluster

PeptideGeneStartEntry
EVPQNLSASRPQDRQ

TRBV30

76

A0A0K0K1B3
RPLVVDPQENRNNNT

CACNA1A

821

O00555
RQPSAPQTLRQRQHT

BRWD1-AS2

46

P59051
IKNRQNAARNNSPPT

ANKLE2

651

Q86XL3
RRNNNRNNSSGRVPT

AGAP1

841

Q9UPQ3
IRSSTQQDPRRRDPQ

CDC14B

31

O60729
KPPNTRENNSSRRAN

AFF2

891

P51816
SSQRDRNGNQLRSPQ

ARHGEF2

721

Q92974
LRQRRDPNGASPTSQ

ARMC5

331

Q96C12
QSPVRTASVNQRNRT

ABI2

226

Q9NYB9
NRPQRSSRSRQNWPK

CD300C

206

Q08708
QLRSPRRAQAPNAQE

RAB4A

201

P20338
PARPGLSQQQRASQR

KAT2A

76

Q92830
SSTLQNNPVPRSRRE

CAPN15

236

O75808
TPRRASSNQRGLNQI

FXN

51

Q16595
RERAAQQQQPSASPR

PBRM1

1441

Q86U86
QRSPPRCSQEANSRK

LILRA4

471

P59901
ESRAQNRRLLPDAPN

PIP5KL1

316

Q5T9C9
QTQDPSRNELQVPRS

H2AP

16

O75409
DNRNPSADRAVSPQR

MTUS1

741

Q9ULD2
PTSQERSSNPAPRRQ

HIPK1

1056

Q86Z02
RSSNPAPRRQQAFVA

HIPK1

1061

Q86Z02
NQRTSPRAPANIQVS

FNDC7

196

Q5VTL7
SPQTRQAGQTRTRIQ

LARP4B

451

Q92615
RVQATFRNADAPSPQ

FBXO31

511

Q5XUX0
RSNTLRERSQQAPPN

PCDHGC5

811

Q9Y5F6
RSAPSCPQNKNRVRN

EPX

286

P11678
QLPPLSQRQSERART

PDE4B

51

Q07343
PRNDRNVFSRLTSNQ

KIF21B

1246

O75037
ASQLSRTQSREPRQQ

HRH2

321

P25021
PASDPSDGQRRRQQQ

POLG

31

P54098
SSNRANPQPRTATRT

FAM161B

336

Q96MY7
FSQISDDRRNPQSPN

EXPH5

631

Q8NEV8
DDRRNPQSPNLQNPT

EXPH5

636

Q8NEV8
NQTTEMRPERQPQTR

CRNN

201

Q9UBG3
QRSRDPGMVRSPQNQ

MCM7

111

P33993
RSPQAFRGQSPNKRN

RBBP6

771

Q7Z6E9
NPQSRPEARSDAGRQ

ICE1

1341

Q9Y2F5
RQNSVRQRPPDASPS

DACT3

281

Q96B18
SLPQQQPAAVARRNE

ASCL1

111

P50553
PRTNPLARANTNNAN

CACNA1S

1651

Q13698
ATQNQRSESNRFPLP

INTS14

131

Q96SY0
TQSQPQRTFPEIQRR

IGHD

46

P01880
AAPSQPNSQIRQNIR

DIDO1

661

Q9BTC0
ASRRPSAAPASQQLQ

ADGRG1

196

Q9Y653
RQQAAASQSPSLPER

ANK3

2001

Q12955
QSRRVQPPAQTRRST

LTBP2

111

Q14767
SQNSDPSRPLQRRMQ

KIRREL3

761

Q8IZU9
QDSTTTRQRRSRQNP

HDAC6

6

Q9UBN7
PTSASLTQRQRQRQQ

CCDC201

106

A0A1B0GTI1
PIERLQRRNSNPSAE

C4orf54

1336

D6RIA3
DSQNLNSRRSPVPAQ

EIF4G3

486

O43432
PQTRSIQSRFLQSRN

PARP6

546

Q2NL67
SQQRRQRVCSAESPP

PCDHA12

751

Q9UN75
STRSPTQRQNPFNEE

PLEKHM2

261

Q8IWE5
ESLQQEARQAPRPNN

NRN1L

96

Q496H8
TRISQPEDSRQPNNV

SZRD1

121

Q7Z422
QRNPDARPSASTLLN

STRADA

361

Q7RTN6
SRGQPRETRNVEPQS

SNX29

796

Q8TEQ0
TSPQANEQSVTPQRR

SRRM2

856

Q9UQ35
TQRRPSASSPNNNTA

PHF2

1051

O75151
PPQSLQQSSRNRISS

PRUNE2

1011

Q8WUY3
RRQLLQDPQEPSARS

MRM1

316

Q6IN84
RSNVTVRNTNQRLEP

RNF6

286

Q9Y252
RQSRQASDAPRNQPP

AGMAT

31

Q9BSE5
ENSPDAQPQAGRRTR

SP1

586

P08047
AQRDNPRASRTSSPN

TRIOBP

456

Q9H2D6
QRDNPRASRTSSPNR

TRIOBP

506

Q9H2D6
AQRDNPRASSPNRAA

TRIOBP

531

Q9H2D6
QRDNPRASSPNRATR

TRIOBP

581

Q9H2D6
PNRATRDNPRTSCAQ

TRIOBP

616

Q9H2D6
RDNPRTSCAQRDNPR

TRIOBP

621

Q9H2D6
RDNPRASSPNRTTQQ

TRIOBP

631

Q9H2D6
SSPNRTIQQENPRTS

TRIOBP

661

Q9H2D6
NPRASSPSRTIQQEN

TRIOBP

681

Q9H2D6
PNRTTQQENPRTSCA

TRIOBP

711

Q9H2D6
QQENPRTSCARRDNP

TRIOBP

716

Q9H2D6
RDNPRTSCAQRDNPR

TRIOBP

741

Q9H2D6
RDNPRASSPNRTIQQ

TRIOBP

751

Q9H2D6
LRASSPIRATQQDNP

TRIOBP

801

Q9H2D6
RVIPVTSRNRDNDPN

POLR2C

126

P19387
PSQDQRLQAQRLRNP

SMURF1

201

Q9HCE7
CPRPTLAQRERNQAS

CHRM5

256

P08912
TALRISQSTFNNPRP

NCOA2

861

Q15596
SAQAQPQPSSSSRQR

SUPT6H

1646

Q7KZ85
TPARQRTQRADTQPS

TMEM31

36

Q5JXX7
DRQRRVFQPSPLASQ

UBXN6

271

Q9BZV1
EPRLSRRQVSSPNAQ

ZNF174

256

Q15697
RNQSPQRLASQASRP

SPEN

251

Q96T58
RNPNIQRQPSRQSER

SYNGAP1

726

Q96PV0
QQRAQSPARPRDSSL

SOGA3

36

Q5TF21
RETLPEPNSQGQRNR

UBL3

91

O95164
NVRQFLPPSRQSSRS

SPIRE1

531

Q08AE8
SPVSSPNQLRQDNRQ

SCEL

196

O95171
FTNSLPEARRNSRQP

THSD1

171

Q9NS62
QAQQRRVTPDRSQTS

SORBS1

1216

Q9BX66
SAENRPEQSLPQQRF

SUPT20H

706

Q8NEM7
QPAERRASNDQRPQE

NISCH

1031

Q9Y2I1
RRSRSQTPSCQNLDP

nan

41

A6NN06
NEAVAPEFTNRNPRN

MRPL18

41

Q9H0U6
RAQQQSQRRLSTSPD

UBE2J1

256

Q9Y385
SSQNRPRADPGIQRQ

VIT

236

Q6UXI7
QNQSIRRPSRQLAPN

ROCK2

1371

O75116
PSRNRENETSRQNLS

ST7L

136

Q8TDW4
RQPERNRSGNQRQST

USF3

1991

Q68DE3
LAPQQRAAPQQKRSS

TNFRSF10B

61

O14763
RRSRSQTPSCQNLDP

nan

41

Q5XG85
RPRSVLNTQPEQTNA

NSD3

421

Q9BZ95
GRDPRPQTSRISQEQ

ZBTB2

156

Q8N680
SALDRRAPTRNQPQA

TNFRSF1B

336

P20333
QSPSNLRDNPFRTTQ

PLEKHA5

936

Q9HAU0
AQSQRSVPSGNRPQQ

TNRC6A

1426

Q8NDV7
RNLQSPTQFQTPRSS

ULK1

446

O75385
NRDPRTTAVSSNRNP

nan

381

Q8N7P7
RPNDPGRSRQNSATR

UNC79

1541

Q9P2D8
IRQRTAAQRNLSPTP

LNPK

166

Q9C0E8
PSLRERRPQQELQNQ

MYO3A

1556

Q8NEV4