Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA secondary structure binding

KMT2A FANCM

1.40e-0341272GO:0000217
PathwayREACTOME_METABOLISM_OF_RNA

CTNNBL1 SMG8 CHERP NSUN2 RPL4 EXOSC4

2.74e-04724196M16843
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

SLC1A3 PPFIA2

4.67e-0424192MM14834
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

SLC1A3 PPFIA2

4.67e-0424192M630
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

ZNF609 CHERP DNAJA1 NSUN2 RPL4 EXOSC4 NOM1

6.83e-0765528735819319
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

ODF2 DNAJA1 NSUN2 EXOSC4 NOM1

1.52e-0624828527926873
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

PPP1R9B CHERP DNAJA1 NSUN2 RPL4 PPFIA2

5.39e-0657328628330616
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

KMT2A ZNF609 CHERP FANCM DNAJA1 RPL4 EXOSC4 NOM1

5.74e-06129428830804502
Pubmed

Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.

CHERP DNAJA1 RPL4 EXOSC4 NOM1

1.26e-0538328529331416
Pubmed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

DNAJA1 NSUN2 RPL4 NOM1

2.88e-0522128429991511
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

CHERP NSUN2 RPL4 EXOSC4

4.73e-0525128428077445
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

PPP1R9B CHERP NSUN2 RPL4

6.65e-0527428434244482
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

PPP1R9B CHERP DNAJA1 NSUN2 RPL4 NOM1

9.15e-0594928636574265
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

KMT2A DNAJA1 RPL4 EXOSC4 NOM1

1.07e-0460128533658012
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

CHERP DNAJA1 NSUN2 RPL4 EXOSC4

1.19e-0461528531048545
Pubmed

Identification of cellular proteins required for replication of human immunodeficiency virus type 1.

AMT DNAJA1

1.30e-042128222404213
Pubmed

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.

NSUN2 NOM1

1.30e-042128225340873
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

CTNNBL1 DNAJA1 NSUN2 RPL4

1.39e-0433228432786267
Pubmed

Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.

CHERP DNAJA1 RPL4 EXOSC4

1.41e-0433328436779763
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

KMT2A SMG8 ZNF609 NSUN2 NOM1

1.55e-0465028538777146
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

KMT2A CHERP DNAJA1 NSUN2 RPL4

1.58e-0465328522586326
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

CHERP DNAJA1 RPL4 EXOSC4 NOM1

1.88e-0467828530209976
Pubmed

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PPP1R9B SLC1A3 PPFIA2

2.24e-0414728316959763
Pubmed

Novel interactors and a role for supervillin in early cytokinesis.

KMT2A ODF2

2.33e-042828220309963
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

CHERP DNAJA1 NSUN2 RPL4 EXOSC4

2.37e-0471328529802200
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

PPP1R9B ZNF609 DNAJA1 EXOSC4 NOM1

2.55e-0472428536232890
Pubmed

UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.

DNAJA1 RPL4 NOM1

2.62e-0415528334921745
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

DNAJA1 NSUN2 RPL4 EXOSC4 NOM1

3.17e-0475928535915203
Pubmed

Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex.

ODF2 MKS1

3.25e-043328230626697
Pubmed

Nucleolar proteome dynamics.

CTNNBL1 DNAJA1 RPL4 EXOSC4

3.38e-0441928415635413
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

PPP1R9B DNAJA1 NSUN2 RPL4 EXOSC4 NOM1

4.19e-04125728636526897
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

CHERP NSUN2 RPL4 NOM1 PURG

4.19e-0480728522681889
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

DNAJA1 NSUN2 RPL4

4.19e-0418228332239614
Pubmed

RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.

CTNNBL1 PPP1R9B RPL4

4.26e-0418328328186131
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

KMT2A DNAJA1 RPL4

4.26e-0418328336129980
Pubmed

High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.

CHERP DNAJA1 NSUN2 RPL4

5.17e-0446928437314180
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

CTNNBL1 KMT2A EXOSC4 NOM1

5.17e-0446928427634302
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

KMT2A CHERP RPL4 EXOSC4 NOM1

5.22e-0484728535850772
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

CTNNBL1 DNAJA1 NSUN2 RPL4 EXOSC4 NOM1

5.76e-04133528629229926
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

DNAJA1 NSUN2 RPL4 NOM1

5.91e-0448628430940648
Pubmed

Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.

COL12A1 CHERP RPL4

5.93e-0420528327976729
Pubmed

Knockout mice with pituitary malformations help identify human cases of hypopituitarism.

NSUN2 MKS1

6.06e-044528238822427
Pubmed

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

KMT2A DNAJA1 EXOSC4

6.99e-0421728331685992
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

ZNF609 DNAJA1 NSUN2

7.28e-0422028335785414
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

CTNNBL1 DNAJA1 NSUN2 SLC1A3 RPL4 EXOSC4

7.82e-04141528628515276
InteractionRPLP0 interactions

KMT2A PPP1R9B CHERP DNAJA1 RPL4 NOM1 PURG

1.12e-05660257int:RPLP0
InteractionRNF113A interactions

ZNF609 CHERP DNAJA1 NSUN2 RPL4 EXOSC4 NOM1

1.53e-05692257int:RNF113A
InteractionSRPK2 interactions

SBK1 CTNNBL1 PPP1R9B CHERP RPL4 NOM1 PURG

1.92e-05717257int:SRPK2
InteractionCIT interactions

CTNNBL1 KMT2A CHERP DNAJA1 NSUN2 SLC1A3 RPL4 EXOSC4 DYRK3

3.58e-051450259int:CIT
InteractionGLDC interactions

PPP1R9B AMT CHERP NSUN2 RPL4

4.06e-05321255int:GLDC
InteractionKRR1 interactions

KMT2A CHERP RPL4 NOM1 PURG

8.93e-05379255int:KRR1
InteractionGRWD1 interactions

KMT2A DNAJA1 NSUN2 RPL4 NOM1

1.02e-04390255int:GRWD1
InteractionTHBS3 interactions

SMG8 NSUN2 MKS1

1.03e-0474253int:THBS3
InteractionPRKRA interactions

KMT2A CHERP RPL4 NOM1 PURG

1.15e-04400255int:PRKRA
InteractionH1-4 interactions

KMT2A PPP1R9B CHERP RPL4 EXOSC4 NOM1

1.21e-04656256int:H1-4
InteractionSURF6 interactions

CTNNBL1 NSUN2 RPL4 NOM1 PURG

1.54e-04426255int:SURF6
InteractionLRP1B interactions

DNAJA1 NMS MKS1

1.56e-0485253int:LRP1B
InteractionRPS16 interactions

PPP1R9B CHERP NSUN2 RPL4 EXOSC4 PURG

2.08e-04724256int:RPS16
InteractionLUC7L interactions

CTNNBL1 CHERP RPL4 NOM1

2.10e-04242254int:LUC7L
InteractionPIH1D1 interactions

KMT2A DNAJA1 NSUN2 RPL4 EXOSC4 MKS1

2.19e-04731256int:PIH1D1
InteractionSIRT7 interactions

CTNNBL1 KMT2A CHERP DNAJA1 NSUN2 RPL4

2.41e-04744256int:SIRT7
InteractionTENT5D interactions

C1orf94 RPL4

2.77e-0420252int:TENT5D
InteractionLRRC49 interactions

SMG8 ODF2 MKS1

2.83e-04104253int:LRRC49
InteractionCHERP interactions

CHERP C1orf94 RPL4 PURG

2.85e-04262254int:CHERP
Cytoband17q22

SMG8 MKS1

3.34e-044428217q22
CytobandEnsembl 112 genes in cytogenetic band chr17q22

SMG8 MKS1

1.33e-0388282chr17q22
CytobandEnsembl 112 genes in cytogenetic band chr15q22

ZNF609 RPL4

2.95e-03132282chr15q22
CytobandEnsembl 112 genes in cytogenetic band chr7q36

GALNT11 NOM1

4.25e-03159282chr7q36
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R9B NOM1

1.23e-02181172694
DiseaseAcute monocytic leukemia

KMT2A FANCM

2.78e-0426282C0023465
Diseasefasting blood glucose measurement

CTNNBL1 AMT NOM1

2.49e-03287283EFO_0004465
Diseasecup-to-disc ratio measurement

KMT2A PPP1R9B COL12A1

7.68e-03430283EFO_0006939
Diseasenasopharyngeal neoplasm

KMT2A PPFIA2

9.01e-03151282EFO_0004252

Protein segments in the cluster

PeptideGeneStartEntry
QKMRRKQTGTRERGR

CTNNBL1

26

Q8WYA6
EMVVLVVMGGRRRRR

H2AL3

126

A0A3B3IU63
LGGQRGFQKERRRMA

C1orf94

11

Q6P1W5
GRMQRERRGKNVVHQ

DNAJA1

96

P31689
MGRRSRGRRLQQQQR

NSUN2

1

Q08J23
GRRAGELRKIQARMG

EXOSC4

16

Q9NPD3
LANRRMKRILQRGSG

NMS

101

Q5H8A3
SPIRLVQRMGRTGRK

FANCM

566

Q8IYD8
VQRMGRTGRKRQGRI

FANCM

571

Q8IYD8
VIKMIQTRGRGRARG

DDX58

721

O95786
VIRNTKREGLIRGRM

GALNT11

216

Q8NCW6
AGKGKMRNRRRIQRR

RPL4

191

P36578
RKMGEGRQQRRAPVG

DCHS2

6

Q6V1P9
ERLQRLQGRGMEKTR

CMPK2

381

Q5EBM0
MRARRRKGQEKRNSG

CHERP

721

Q8IWX8
RTQAGMRPRARKIGV

COL12A1

1291

Q99715
MGGRMERFQQGVRKR

SLC1A3

11

P43003
QIGRKGVQIVRRRGR

KMT2A

291

Q03164
QLKGRVQRRRVGLMC

AMT

311

P48728
GMTRRVGCRVKRVSG

SBK1

196

Q52WX2
RVVLVGGRSRRGKKR

DYRK3

461

O43781
TTKVIRRPRRGRMGV

PPFIA2

571

O75334
QRGRFLRIRQTMMRG

PURG

191

Q9UJV8
RGMKGDTVNVRRSVR

ODF2

46

Q5BJF6
GKRSAVVMGRGRRRD

SMG8

826

Q8ND04
MRRCLRVKTRRGQLG

SMCR5

1

Q8TEV8
QGRVVRMKRRGGRGP

NOM1

16

Q5C9Z4
RQDRRGMEGGILKSR

MKS1

166

Q9NXB0
RNGRGRGKRMRPNSN

ZNF609

366

O15014
NTKGRVRFMIGRERP

PPP1R9B

571

Q96SB3