Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF729 CPHXL ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 CPHXL2 ZNF766 ZNF470 ZNF350 CXXC1 TOP1 GLIS1	1.11e-06	1271	55	15	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF729 CPHXL USF3 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 CPHXL2 NFX1 ZNF766 ZNF470 ZNF350 TOP1 GLIS1	1.18e-06	1459	55	16	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF729 CPHXL USF3 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 CPHXL2 NFX1 ZNF766 ZNF470 ZNF350 GLIS1	4.12e-06	1412	55	15	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF729 CPHXL ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 CPHXL2 ZNF766 ZNF470 ZNF350 TOP1 GLIS1	4.81e-06	1244	55	14	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF729 USF3 ZFAT GZF1 EGR2 EGR3 EGR4 GLIS1	1.39e-04	560	55	8	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF729 USF3 ZFAT GZF1 EGR2 EGR3 EGR4 GLIS1	1.49e-04	566	55	8	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF729 GZF1 NFX1 ZNF350 GLIS1	1.85e-03	320	55	5	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF729 GZF1 NFX1 ZNF350 GLIS1	2.01e-03	326	55	5	GO:0001217
MousePheno	abnormal abducens nerve morphology	EGR2 KIF21A	5.27e-05	4	42	2	MP:0001070
Domain	NPIP	NPIPB13 NPIPB3 NPIPB5 NPIPA2	7.09e-08	14	56	4	IPR009443
Domain	ZINC_FINGER_C2H2_1	ZNF729 TUT4 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 ZFR ZNF766 ZNF470 ZNF350 GLIS1	3.65e-07	777	56	13	PS00028
Domain	Znf_C2H2-like	ZNF729 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 ZFR ZNF766 ZNF470 ZNF350 ZMAT1 GLIS1	4.80e-07	796	56	13	IPR015880
Domain	Znf_C2H2	ZNF729 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 ZFR ZNF766 ZNF470 ZNF350 ZMAT1 GLIS1	5.45e-07	805	56	13	IPR007087
Domain	ZnF_C2H2	ZNF729 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 ZFR ZNF766 ZNF470 ZNF350 ZMAT1 GLIS1	5.68e-07	808	56	13	SM00355
Domain	-	ZNF729 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 ZNF766 ZNF470 ZNF350 GLIS1	4.53e-06	679	56	11	3.30.160.60
Domain	zf-C2H2	ZNF729 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 ZNF766 ZNF470 ZNF350 GLIS1	5.50e-06	693	56	11	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 ZNF766 ZNF470 ZNF350 GLIS1	5.58e-06	694	56	11	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF729 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 ZNF766 ZNF470 ZNF350 GLIS1	1.58e-05	775	56	11	PS50157
Domain	DUF3446	EGR2 EGR3	2.64e-05	3	56	2	IPR021849
Domain	DUF3446	EGR2 EGR3	2.64e-05	3	56	2	PF11928
Domain	Actinin_actin-bd_CS	SPTBN5 SYNE1	2.15e-03	23	56	2	IPR001589
Domain	ACTININ_2	SPTBN5 SYNE1	2.15e-03	23	56	2	PS00020
Domain	ACTININ_1	SPTBN5 SYNE1	2.15e-03	23	56	2	PS00019
Domain	Spectrin	SPTBN5 SYNE1	2.15e-03	23	56	2	PF00435
Domain	SPRY	TRIM9 HERC1 CMYA5	2.82e-03	94	56	3	PF00622
Domain	SPRY_dom	TRIM9 HERC1 CMYA5	2.82e-03	94	56	3	IPR003877
Domain	B30.2/SPRY	TRIM9 HERC1 CMYA5	2.91e-03	95	56	3	IPR001870
Domain	B302_SPRY	TRIM9 HERC1 CMYA5	2.91e-03	95	56	3	PS50188
Domain	ZnF_U1	ZFR ZMAT1	3.40e-03	29	56	2	SM00451
Domain	Znf_U1	ZFR ZMAT1	3.40e-03	29	56	2	IPR003604
Domain	Spectrin_repeat	SPTBN5 SYNE1	3.40e-03	29	56	2	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN5 SYNE1	4.13e-03	32	56	2	IPR018159
Domain	SPEC	SPTBN5 SYNE1	4.13e-03	32	56	2	SM00150
Domain	KRAB	ZNF729 ZNF570 ZNF766 ZNF470 ZNF350	4.32e-03	358	56	5	PS50805
Domain	KRAB	ZNF729 ZNF570 ZNF766 ZNF470 ZNF350	4.32e-03	358	56	5	PF01352
Domain	KRAB	ZNF729 ZNF570 ZNF766 ZNF470 ZNF350	4.90e-03	369	56	5	SM00349
Domain	KRAB	ZNF729 ZNF570 ZNF766 ZNF470 ZNF350	4.96e-03	370	56	5	IPR001909
Pathway	REACTOME_NGF_STIMULATED_TRANSCRIPTION	EGR2 EGR3 EGR4	1.54e-04	39	38	3	M29793
Pathway	WP_OREXIN_RECEPTOR_PATHWAY	EGR2 EGR3 TRIM9 DDX52 GLIS1	1.88e-04	200	38	5	M48048
Pathway	PID_NFAT_TFPATHWAY	EGR2 EGR3 EGR4	2.37e-04	45	38	3	M60
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	EGR2 EGR3 EGR4	5.84e-04	61	38	3	M152
Pubmed	An amphioxus Krox gene: insights into vertebrate hindbrain evolution.	EGR2 EGR3 EGR4	1.95e-08	4	60	3	11180801
Pubmed	Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse.	EGR2 EGR3 EGR4	1.95e-08	4	60	3	11891986
Pubmed	No association between EGR gene family polymorphisms and schizophrenia in the Chinese population.	EGR2 EGR3 EGR4	9.73e-08	6	60	3	20144677
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	RPL21 TUT4 NSA2 DDX52 SYNE1 DHX38 NFX1 ZFR TOP1 GNL3	1.13e-06	807	60	10	22681889
Pubmed	EGR1 and EGR2 involvement in vertebrate tendon differentiation.	EGR2 EGR3 EGR4	1.38e-06	13	60	3	21173153
Pubmed	EGR3 as a potential susceptibility gene for schizophrenia in Korea.	EGR2 EGR3	2.93e-06	2	60	2	20687139
Pubmed	Genetic and functional analyses of early growth response (EGR) family genes in schizophrenia.	EGR2 EGR4	2.93e-06	2	60	2	22691714
Pubmed	The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells.	EGR2 EGR3	2.93e-06	2	60	2	23021953
Pubmed	Egr-2 and Egr-3 are negative regulators of T cell activation.	EGR2 EGR3	2.93e-06	2	60	2	15834410
Pubmed	Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.	EGR2 EGR3	2.93e-06	2	60	2	29314730
Pubmed	Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.	EGR2 EGR3	2.93e-06	2	60	2	28487311
Pubmed	NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression.	EGR2 EGR3	2.93e-06	2	60	2	23485457
Pubmed	Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity.	EGR2 EGR3	2.93e-06	2	60	2	27856665
Pubmed	Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cells.	EGR2 EGR3	2.93e-06	2	60	2	32709717
Pubmed	Interaction of brefeldin A-inhibited guanine nucleotide-exchange protein (BIG) 1 and kinesin motor protein KIF21A.	KIF21A ARFGEF1	2.93e-06	2	60	2	19020088
Pubmed	Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.	EGR2 EGR3	2.93e-06	2	60	2	36342511
Pubmed	Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.	EGR2 EGR3 EGR4	3.91e-06	18	60	3	9858769
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPL21 FAM184B FRA10AC1 NSA2 DDX52 SYNE1 KIF21A ZFR ZNF350 C2orf78 CXXC1 TOP1	5.45e-06	1442	60	12	35575683
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	RPL21 ARHGAP5 PBRM1 GZF1 ZFR TOP1 GNL3	7.57e-06	417	60	7	36537216
Pubmed	Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint.	EGR2 EGR3	8.77e-06	3	60	2	35045301
Pubmed	Early growth response transcriptional regulators are dispensable for macrophage differentiation.	EGR2 EGR3	8.77e-06	3	60	2	17312150
Pubmed	Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.	EGR2 EGR3	8.77e-06	3	60	2	15173177
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	8.77e-06	3	60	2	11948212
Pubmed	Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells.	EGR2 EGR3	8.77e-06	3	60	2	28455436
Pubmed	Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.	EGR2 EGR3	8.77e-06	3	60	2	27911796
Pubmed	Early Growth Response Genes 2 and 3 Regulate the Expression of Bcl6 and Differentiation of T Follicular Helper Cells.	EGR2 EGR3	8.77e-06	3	60	2	25979336
Pubmed	Early growth response genes 2 and 3 induced by AP-1 and NF-κB modulate TGF-β1 transcription in NK1.1- CD4+ NKG2D+ T cells.	EGR2 EGR3	8.77e-06	3	60	2	33011290
Pubmed	BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex.	BMP2 PHLDB2	8.77e-06	3	60	2	24885555
Pubmed	Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.	EGR2 EGR3	8.77e-06	3	60	2	19706684
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	RPL21 PBRM1 NSA2 DDX52 DHX38 ZFR TOP1 GNL3	9.25e-06	605	60	8	28977666
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	RPL21 ARHGAP5 CCPG1 PBRM1 NSA2 DDX52 DHX38 ZFR TOP1	1.40e-05	847	60	9	35850772
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ARHGAP5 FAM184B NSA2 DDX52 DHX38 NFX1 GFPT2 HERC1 ZMAT1 KIAA0753	1.52e-05	1084	60	10	11544199
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RPL21 PBRM1 NSA2 DDX52 DHX38 ZFR TOP1 GNL3	1.60e-05	653	60	8	22586326
Pubmed	Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.	KIF21A ARFGEF1	1.75e-05	4	60	2	22084092
Pubmed	EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.	EGR2 EGR3	1.75e-05	4	60	2	20506119
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	RPL21 ARHGAP5 PBRM1 MTIF2 NFX1 ZFR TOP1	1.75e-05	475	60	7	31040226
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	RPL21 PBRM1 NSA2 DDX52 ZFR TOP1 GNL3	1.95e-05	483	60	7	36912080
Pubmed	Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development.	CPHXL CPHXL2	2.92e-05	5	60	2	26360614
Pubmed	Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.	EGR2 EGR3	2.92e-05	5	60	2	30012846
Pubmed	Integrated analysis of DNA methylation and RNA‑sequencing data in Down syndrome.	EGR2 EGR3	2.92e-05	5	60	2	27667480
Pubmed	Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells.	EGR2 EGR3	2.92e-05	5	60	2	29728568
Pubmed	Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.	EGR2 EGR4	2.92e-05	5	60	2	12560487
Pubmed	The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells.	EGR2 EGR3	2.92e-05	5	60	2	19169262
Pubmed	Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.	EGR2 EGR3	2.92e-05	5	60	2	18203138
Pubmed	CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.	KIF21A PHLDB2	2.92e-05	5	60	2	24120883
Pubmed	HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.	EGR2 EGR3	2.92e-05	5	60	2	11909874
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FAM184B CCPG1 SYNE1 PARP14	3.11e-05	103	60	4	10574462
Pubmed	HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.	EGR2 EGR3 EGR4	3.94e-05	38	60	3	25613138
Pubmed	Bone morphogenetic protein 2- and estradiol-17β-induced changes in ovarian transcriptome during primordial follicle formation†.	BMP2 EGR2	4.37e-05	6	60	2	35639639
Pubmed	Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system.	EGR2 EGR3	4.37e-05	6	60	2	37443284
Pubmed	Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses.	EGR2 EGR3	4.37e-05	6	60	2	14560009
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	PBRM1 SYNE1 TEX15 HERC1 GNL3	5.34e-05	234	60	5	36243803
Pubmed	Regulation of low affinity neurotrophin receptor (p75(NTR)) by early growth response (Egr) transcriptional regulators.	EGR2 EGR3	6.11e-05	7	60	2	17916431
Pubmed	Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.	PBRM1 GNL3	6.11e-05	7	60	2	22763110
Pubmed	Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice.	BMP2 EGR2	6.11e-05	7	60	2	17900554
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RPL21 NSA2 DDX52 KIF21A DHX38 ZFR CXXC1 TOP1 GNL3 PHLDB2	9.84e-05	1353	60	10	29467282
Pubmed	Human transcription factor protein interaction networks.	PBRM1 TRIM9 NSA2 DDX52 ZFR GFPT2 HERC1 CXXC1 TOP1 GNL3	1.54e-04	1429	60	10	35140242
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	SYNE1 ZNF350	1.59e-04	11	60	2	27621083
Pubmed	Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.	EGR2 EGR3	1.59e-04	11	60	2	23792428
Pubmed	Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.	PBRM1 ZFR TOP1 GNL3	1.68e-04	159	60	4	22751105
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	GZF1 EGR2 ARFGEF1 NPIPB3 ZNF766 ZNF470 CMYA5 ODAD3	1.70e-04	915	60	8	32393512
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	RPL21 NSA2 DDX52 SYNE1 ZFR GFPT2 TOP1 GNL3	2.18e-04	949	60	8	36574265
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	SPTBN5 TUT4 NSA2 MTIF2 SYNE1 NFX1 ZFR HERC1 TOP1 GNL3	2.23e-04	1496	60	10	32877691
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	RPL21 DDX52 SYNE1 DHX38 ZFR TOP1 GNL3	2.24e-04	714	60	7	28302793
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	PBRM1 NSA2 KIF21A TOP1 GNL3	2.66e-04	330	60	5	33301849
Pubmed	Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome.	RPL21 TOP1 GNL3	2.67e-04	72	60	3	12777385
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	PBRM1 NSA2 DDX52 SYNE1 GNL3	2.73e-04	332	60	5	25693804
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	RPL21 PBRM1 NSA2 DHX38 TOP1 GNL3	3.13e-04	533	60	6	30554943
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RPL21 PBRM1 NSA2 DDX52 ZFR TOP1 GNL3	3.25e-04	759	60	7	35915203
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ARHGAP5 TRIM9 MTIF2 SYNE1 KIF21A ZNF350 GFPT2 CMYA5 TOP1	3.38e-04	1285	60	9	35914814
Pubmed	The mouse Ovol2 gene is required for cranial neural tube development.	BMP2 EGR2	3.46e-04	16	60	2	16423343
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RPL21 PBRM1 DDX52 SYNE1 ZFR TOP1 GNL3 PHLDB2	3.62e-04	1024	60	8	24711643
Pubmed	Characterization of 16 novel human genes showing high similarity to yeast sequences.	NSA2 DDX52	3.91e-04	17	60	2	11124703
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	NPIPB4 DHX38 NPIPB3	4.07e-04	83	60	3	9039502
Pubmed	EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.	RPL21 TOP1	4.40e-04	18	60	2	15064750
Pubmed	Genome-wide association of mood-incongruent psychotic bipolar disorder.	PBRM1 GNL3	4.40e-04	18	60	2	23092984
Pubmed	Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.	GZF1 EGR4	4.91e-04	19	60	2	30385546
Pubmed	Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression.	BMP2 EGR2	4.91e-04	19	60	2	22075149
Pubmed	Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development.	PBRM1 EGR2	4.91e-04	19	60	2	35173232
Pubmed	PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis.	PBRM1 DDX52 GNL3	5.15e-04	90	60	3	30699358
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	RPL21 ARHGAP5 PBRM1 GZF1 NSA2 DDX52 NFX1 TOP1 GNL3	5.41e-04	1371	60	9	36244648
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	PBRM1 DDX52 ZFR TOP1	5.66e-04	219	60	4	31353912
Pubmed	Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.	PBRM1 GNL3	6.02e-04	21	60	2	22479202
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	RPL21 ZFR TOP1 GNL3	6.06e-04	223	60	4	20020773
Pubmed	Ectopic expression of Hoxb1 induces cardiac and craniofacial malformations.	BMP2 EGR2	6.61e-04	22	60	2	30134070
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RPL21 PBRM1 DDX52 SYNE1 DHX38 ZFR CMYA5 TOP1 GNL3	7.13e-04	1425	60	9	30948266
Pubmed	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	EGR2 EGR3	7.23e-04	23	60	2	20379146
Pubmed	Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.	PBRM1 SYNE1 GNL3	7.42e-04	102	60	3	21926972
Pubmed	Nucleolar proteome dynamics.	RPL21 NSA2 DDX52 ZFR TOP1	7.85e-04	419	60	5	15635413
Pubmed	Functional proteomic analysis of human nucleolus.	NSA2 DDX52 GNL3	8.30e-04	106	60	3	12429849
Pubmed	Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.	FRA10AC1 PBRM1	1.23e-03	30	60	2	11483580
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	CDKL5 EGR3	1.32e-03	31	60	2	27798109
Pubmed	DNA-binding specificities of human transcription factors.	EGR3 EGR4	1.32e-03	31	60	2	23332764
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	RPL21 NSA2 DDX52 DHX38 ZFR TOP1 GNL3 PHLDB2	1.37e-03	1257	60	8	36526897
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	RPL21 NSA2 DDX52 DHX38 ZFR TOP1 GNL3	1.53e-03	989	60	7	36424410
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	RPL21 NSA2 DDX52 ZFR TOP1 GNL3	1.61e-03	731	60	6	29298432
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RPL21 PBRM1 DDX52 DHX38 ZFR CXXC1 TOP1 GNL3	1.65e-03	1294	60	8	30804502
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	SPTBN5 ZFR CXXC1 GNL3 PHLDB2	1.66e-03	496	60	5	31343991
Pubmed	Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.	BMP2 FAM184B ZFAT	1.70e-03	136	60	3	25429064
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	1.60e-05	37	60	3	16p12.2
Cytoband	3q13.2	USF3 PHLDB2	7.62e-04	31	60	2	3q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB4 NPIPB3 NPIPB5	1.51e-03	172	60	3	chr16p12
Cytoband	1p32.3	TUT4 GLIS1	2.93e-03	61	60	2	1p32.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 ZFAT GZF1 EGR2 EGR3 EGR4 ZNF570 ZNF766 ZNF470 ZNF350 GLIS1	4.45e-08	718	34	11	28
GeneFamily	PHD finger proteins	NFX1 CXXC1	1.24e-02	90	34	2	88
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM9 CMYA5	1.37e-02	95	34	2	59
Coexpression	GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_DN	USF3 EGR2 CRTAM GFPT2 HERC1 ZMAT1	3.47e-06	189	57	6	M8275
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	EGR4 SYNE1 KIF21A CRTAM NPIPB3 GFPT2	1.43e-07	177	60	6	84930899eb2978598bc8a351cbcd9e714e46799d
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPIPB4 SYNE1 ARFGEF1 HERC1 NPIPB5 PARP14	2.85e-07	199	60	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF729 FAM184B NPIPB13 EGR2 KCNN3	2.27e-06	157	60	5	beab0ac47202266b04543c02cfcdda012375e879
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 PBRM1 KIF21A PALMD TOP1	5.47e-06	188	60	5	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21A ARFGEF1 ZFR HERC1 PHLDB2	6.54e-06	195	60	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21A ARFGEF1 ZFR HERC1 PHLDB2	6.54e-06	195	60	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	CPHXL NPIPB4 SYNE1 HERC1	3.32e-05	135	60	4	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Rrad\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	EGR2 EGR3 EGR4 PALMD	3.62e-05	138	60	4	b3a040c5d0e1cc94d9b19155bca8700edba2d243
ToppCell	metastatic_Brain-T/NK_cells-Naive_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	CDKL5 CMYA5 GLIS1 FRMD5	4.63e-05	147	60	4	4f7a0c287721befeffabf95b8c5f9ff64149c7c1
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKL5 EGR2 EGR4 CMYA5	5.54e-05	154	60	4	2d98bb7a784fc3215e0d4a1670d662e5df4716c3
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKL5 EGR2 EGR4 CMYA5	5.54e-05	154	60	4	0dec222101530f1727184dbb7c03969d3884f111
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	USF3 ZFAT NPIPB4 GFPT2	7.08e-05	164	60	4	d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell	10x5'-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	BMP2 EGR4 CRTAM PHLDB2	7.42e-05	166	60	4	ba42349a68b22e91a0340bda1ccecd6c7592392f
ToppCell	systemic_lupus_erythematosus-flare-Hematopoietic-Progen-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CDKL5 FAM184B TUT4 TRIM9	7.59e-05	167	60	4	b89ebd4906f52b1fe6b6540ec9339284e7caddd2
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-TRGV5/7_gdT\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPTBN5 NFX1 ZNF350 HERC1	7.77e-05	168	60	4	235c368669c017e13a7312fce3d8b91d7d106c7a
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	TUT4 NPIPB4 SYNE1 HERC1	8.32e-05	171	60	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 DHX38 ARFGEF1 GLIS1	9.10e-05	175	60	4	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 SYNE1 PALMD PARP14	9.72e-05	178	60	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNN3 NPIPB3 NPIPB5 ZMAT1	9.72e-05	178	60	4	ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GZF1 NPIPB13 EGR2 EGR3	1.06e-04	182	60	4	4a85429d365c4b2d73fc921f261b4b7635ac40bd
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GZF1 NPIPB13 EGR2 EGR3	1.06e-04	182	60	4	53213af34af3337f5edc734d3b7b79e4349eac0d
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GZF1 NPIPB13 EGR2 EGR3	1.06e-04	182	60	4	7909089ed6325c44edd6f9b7e8b1d542398222ea
ToppCell	CD8+_Memory_T_cell-RSV-0\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	RPL21 EGR2 NSA2 CRTAM	1.15e-04	186	60	4	7926941dc44db3c1272778cb45127efd99e6f4b1
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	NPIPB4 ARFGEF1 HERC1 PARP14	1.20e-04	188	60	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Control-Lymphoid-T_Cytotoxic\|Lymphoid / Disease state, Lineage and Cell class	RPL21 KIF21A CRTAM GFPT2	1.27e-04	191	60	4	ff7204f9b645233548cf804cf6fe0c86417be87f
ToppCell	droplet-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSA2 KIF21A PALMD TOP1	1.33e-04	193	60	4	cba070019db30604ebddb610eedf92e48221ac58
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	EGR2 PALMD GFPT2 PHLDB2	1.33e-04	193	60	4	194e7fa00a50cc4e026987b715323d125d79594e
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RPL21 NPIPB4 NPIPB3 NPIPB5	1.33e-04	193	60	4	9c9434a3297b85774b4f0ecab6294f44d738e29f
ToppCell	droplet-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSA2 KIF21A PALMD TOP1	1.33e-04	193	60	4	07ddb9525b686c31fa7df4286557d1e58f7ead52
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPIPB4 SYNE1 HERC1 NPIPB5	1.33e-04	193	60	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 KIF21A CRTAM GFPT2	1.35e-04	194	60	4	b0a7f5ca0c6f4f5764a8b35b5de80d82b828c66c
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT2-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	BMP2 EGR2 EGR3 EGR4	1.35e-04	194	60	4	5bfc26668fa8f109f2ebc0d5fd98ab5bd219e62c
ToppCell	10x5'-Lung-Lymphocytic_T_CD8-Trm/em_CD8\|Lung / Manually curated celltypes from each tissue	RPL21 SYNE1 CRTAM GFPT2	1.41e-04	196	60	4	cbb63b9ea85b2060e90dd551aa4e697b3f1494fc
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPIPB4 SYNE1 HERC1 NPIPB5	1.44e-04	197	60	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	distal-Endothelial-Bronchial_Vessel_2-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EGR3 KCNN3 ZNF470 PALMD	1.44e-04	197	60	4	9fcfbfbe78e8fe90c76eb37a58ed9dc8ece652a1
ToppCell	tumor_Lung-Epithelial_cells-tS1\|Epithelial_cells / Location, Cell class and cell subclass	RPL21 BMP2 EGR2 SYNE1	1.44e-04	197	60	4	7190143468939cf26c069d125a5e88e4bf026299
ToppCell	distal-3-Endothelial-Bronchial_Vessel_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EGR3 KCNN3 ZNF470 PALMD	1.46e-04	198	60	4	f701d06e3d7fd2192afae3698c5ec3c355e96da3
ToppCell	Biopsy_Control_(H.)-Epithelial-KRT5-/KRT17+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	SPTBN5 BMP2 BNIP5 FRMD5	1.49e-04	199	60	4	3b1f56c8b40bb36922a31d2d440a8c468a8aa3f1
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD8+_Tem\|Int-URO / Disease, condition lineage and cell class	RPL21 SYNE1 KIF21A CRTAM	1.52e-04	200	60	4	d17a9e3b215490ef9dfc560ff43f190fc688ddc2
Disease	Rett Syndrome	CDKL5 EGR2	3.40e-05	5	55	2	C0035372
Disease	diet measurement, body mass index	FRA10AC1 CMYA5	6.34e-04	20	55	2	EFO_0004340, EFO_0008111
Disease	atrial fibrillation	ZFAT KCNN3 PALMD HERC1 PHLDB2	6.35e-04	371	55	5	EFO_0000275
Disease	lung carcinoma, family history of lung cancer	SYT9 KIAA0753	1.34e-03	29	55	2	EFO_0001071, EFO_0006953
Disease	waist-hip ratio	BMP2 ZFAT PBRM1 ARFGEF1 KCNN3 TOP1 GNL3 PHLDB2	1.86e-03	1226	55	8	EFO_0004343
Disease	Bipolar Disorder	PBRM1 EGR2 EGR3 SYNE1 KCNN3	1.93e-03	477	55	5	C0005586
Disease	Facial wrinkling	GFPT2 GLIS1	2.18e-03	37	55	2	HP_0009762
Disease	Paroxysmal atrial fibrillation	KCNN3 HERC1 PHLDB2	3.11e-03	156	55	3	C0235480
Disease	Persistent atrial fibrillation	KCNN3 HERC1 PHLDB2	3.11e-03	156	55	3	C2585653
Disease	familial atrial fibrillation	KCNN3 HERC1 PHLDB2	3.11e-03	156	55	3	C3468561
Disease	Atrial Fibrillation	KCNN3 HERC1 PHLDB2	3.34e-03	160	55	3	C0004238

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKEKINFLRNKHKIH	DDX52	136	Q9Y2R4
GRVSVHCKKKHKREE	CCDC117	61	Q8IWD4
VIKGHSDQVRKNKHK	C2orf78	491	A6NCI8
ADKEVKKAHHSQLRK	ARFGEF1	21	Q9Y6D6
FKRKKDVKRHVLQVH	GZF1	386	Q9H116
LHKREKRQAKHKQRK	BMP2	276	P12643
HEKKRKKESREAHER	NSA2	21	O95478
KIRKRKVTTKINHHD	NPIPB3	156	Q92617
DERKRHTKIHLRQKE	EGR2	411	P11161
KIRKRKVTTKINHHD	NPIPB12	156	F8W0I5
QKRLKIEEDKLKHQH	PALMD	26	Q9NP74
KHLHNDVEKERKEKL	PBRM1	896	Q86U86
KIIEEKRKEHKEAHQ	MTIF2	461	P46199
RKIKHQTEEEKKHLK	FAM184B	411	Q9ULE4
TKRHEKKHRHESEEK	HERC1	2411	Q15751
IKLNFHHRRKEIKSK	FRA10AC1	216	Q70Z53
KIDHAKVRKHQRKFL	KCNN3	591	Q9UGI6
WQKLRNEKHHIRVKK	NFX1	106	Q12986
KIRKRKVTTKINHHD	NPIPB5	156	A8MRT5
ARSDEKKRHSKVHLK	EGR4	551	Q05215
RHDKINGKRKTAKEH	NPIPA2	151	E9PIF3
KIRKRKVTTKINHHD	NPIPB4	156	C9JG80
REKKKTVDVKINHRH	PARP14	1561	Q460N5
KHSEKLERKIAEIHK	FRMD5	166	Q7Z6J6
KEFVRHHKEKIKQAK	CCPG1	501	Q9ULG6
KEERYKRHRQKQKHK	CXXC1	341	Q9P0U4
RKKQGHKKHAAEVTK	BNIP5	156	P0C671
NHEVKERHIQLVKKR	GFPT2	46	O94808
KRKENVQHSKLEEKH	CRTAM	371	O95727
DHHNEERQTKKKRKT	CPHXL2	11	A0A1W2PPK0
DERKRHAKIHLKQKE	EGR3	346	Q06889
DEVKKVRKRTHKSKH	CMYA5	126	Q8N3K9
IQKKVREHHRKLRKE	GNL3	21	Q9BVP2
KHVKAHSAKEQQVRK	GLIS1	341	Q8NBF1
RHKETHEIVAIKKFK	CDKL5	31	O76039
HHNEERQTKNKRKTK	CPHXL	16	A0A1W2PPM1
KIRKRKVTTKINHHD	NPIPB13	156	A6NJU9
PDRKTKHQTKVHRKT	SYT9	266	Q86SS6
LHHQQKTKRISAKKR	SYNE1	1276	Q8NF91
KIRSQKLIESHKKHR	ODAD3	576	A5D8V7
KHIEQLKQEHIRKRR	ARHGAP5	321	Q13017
RDVKRRQFEKHIKEH	KIAA0753	106	Q2KHM9
KEHFRSLEERKKQHK	PHLDB2	876	Q86SQ0
QSLHRKHKELQVEVK	SPTBN5	1556	Q9NRC6
LKVHIERVHKKIKQH	ZFAT	341	Q9P243
RAVKHLFKSIEEKKH	KIF21A	116	Q7Z4S6
THSVVKKHKQDRGEK	ZNF470	211	Q6ECI4
AKRINVRIEHIKHSK	RPL21	86	P46778
VRKHREQKERKKAQH	DHX38	451	Q92620
ETHNAVERHRKKKIN	USF3	21	Q68DE3
ARVNKEHEHKLKVVR	TRIM9	336	Q9C026
CLVKHKRIHTREKQE	ZNF350	416	Q9GZX5
IRGAKHQKVVKLHTK	ZFR	401	Q96KR1
EEKVHKHDTQKRSFK	ZNF570	186	Q96NI8
LVRHQKIHTREKPHK	ZNF766	286	Q5HY98
KLDKAVVHLKKAHRR	TEX15	996	Q9BXT5
IQGAHKHIKEKRHKK	TUT4	316	Q5TAX3
REHRHKEHKKEKDRE	TOP1	31	P11387
HKTIHTREKPTNVKK	ZNF729	1206	A6NN14
QKHQKRKRHLEEGKE	ZMAT1	536	Q5H9K5