Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1E CACNB3 CACNB4	2.71e-05	14	86	3	GO:0008331
GeneOntologyMolecularFunction	flippase activity	TMEM30B ATP8A2 ATP10A	5.02e-05	17	86	3	GO:0140327
GeneOntologyMolecularFunction	phosphotransferase activity, for other substituted phosphate groups	SAMD8 FKTN SELENOI	1.12e-04	22	86	3	GO:0016780
GeneOntologyMolecularFunction	protein kinase A binding	ARFGEF2 ARFGEF1 NBEA LRBA	1.14e-04	58	86	4	GO:0051018
GeneOntologyMolecularFunction	metalloendopeptidase activity	CLCA4 MMP21 ADAM29 MMP16 MMP19	1.70e-04	120	86	5	GO:0004222
GeneOntologyMolecularFunction	protein-arginine omega-N monomethyltransferase activity	PRMT6 PRMT8	1.82e-04	5	86	2	GO:0035241
GeneOntologyMolecularFunction	metallopeptidase activity	CPA6 CLCA4 MMP21 ADAM29 MMP16 MMP19	2.26e-04	200	86	6	GO:0008237
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	TMEM30B ATP8A2 ATP10A	2.34e-04	28	86	3	GO:0140326
GeneOntologyMolecularFunction	calcium channel activity	CACNA1E CACNB3 CACNB4 GRIN2C ITPR2	2.39e-04	129	86	5	GO:0005262
GeneOntologyMolecularFunction	aminophospholipid flippase activity	TMEM30B ATP8A2	3.80e-04	7	86	2	GO:0015247
GeneOntologyMolecularFunction	MutSalpha complex binding	ATR MLH1	3.80e-04	7	86	2	GO:0032407
GeneOntologyMolecularFunction	protein-arginine omega-N asymmetric methyltransferase activity	PRMT6 PRMT8	3.80e-04	7	86	2	GO:0035242
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1E CACNB3 CACNB4 GRIN2C ITPR2	4.93e-04	151	86	5	GO:0015085
GeneOntologyMolecularFunction	peptidase activity	CPA6 ATXN3L CLCA4 USP11 PARL ATXN3 MMP21 ADAM29 MMP16 MMP19	5.00e-04	654	86	10	GO:0008233
GeneOntologyMolecularFunction	gated channel activity	CACNA1E CACNB3 CACNB4 CLCA4 GRIN2C KCNH5 ITPR2	5.97e-04	334	86	7	GO:0022836
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1E CACNB4	6.47e-04	9	86	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1E CACNB4	6.47e-04	9	86	2	GO:0099626
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1E CACNB3 CACNB4 GRIN2C UNC80 KCNH5 ITPR2	6.98e-04	343	86	7	GO:0005261
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1E CACNB3 CACNB4 CLCA4 GRIN2C UNC80 KCNH5 ITPR2	8.12e-04	459	86	8	GO:0005216
GeneOntologyMolecularFunction	mismatch repair complex binding	ATR MLH1	9.83e-04	11	86	2	GO:0032404
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1E CACNB3 CACNB4	1.02e-03	46	86	3	GO:0005245
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1E CACNB3 CACNB4 GRIN2C KCNH5	1.14e-03	182	86	5	GO:0005244
GeneOntologyMolecularFunction	transporter activity	TMEM30B CACNA1E CACNB3 CACNB4 CLCA4 ATP8A2 LRP2 SLC35F2 GRIN2C ATP10A UNC80 ATP6V0A2 KCNH5 ITPR2	1.16e-03	1289	86	14	GO:0005215
GeneOntologyMolecularFunction	arginine N-methyltransferase activity	PRMT6 PRMT8	1.18e-03	12	86	2	GO:0016273
GeneOntologyMolecularFunction	protein-arginine N-methyltransferase activity	PRMT6 PRMT8	1.18e-03	12	86	2	GO:0016274
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1E CACNB3 CACNB4 GRIN2C KCNH5	1.20e-03	184	86	5	GO:0022832
GeneOntologyMolecularFunction	ATP-dependent activity	TMEM30B DNAH3 MYO7B ATP8A2 DNAH17 MLH1 CHD3 ATP10A ATP6V0A2	1.30e-03	614	86	9	GO:0140657
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	TMEM30B ATP8A2 ATP10A	1.38e-03	51	86	3	GO:0140303
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	ATP8A2 ATP10A	1.61e-03	14	86	2	GO:0140333
GeneOntologyMolecularFunction	channel activity	CACNA1E CACNB3 CACNB4 CLCA4 GRIN2C UNC80 KCNH5 ITPR2	1.91e-03	525	86	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1E CACNB3 CACNB4 CLCA4 GRIN2C UNC80 KCNH5 ITPR2	1.93e-03	526	86	8	GO:0022803
GeneOntologyMolecularFunction	transcription corepressor binding	ATXN3L USP11 ATXN3	2.11e-03	59	86	3	GO:0001222
GeneOntologyMolecularFunction	K63-linked deubiquitinase activity	ATXN3L ATXN3	2.12e-03	16	86	2	GO:0061578
GeneOntologyMolecularFunction	floppase activity	ATP8A2 ATP10A	2.12e-03	16	86	2	GO:0140328
GeneOntologyMolecularFunction	histone H4 methyltransferase activity	PRMT6 PRMT8	2.39e-03	17	86	2	GO:0140939
GeneOntologyMolecularFunction	endopeptidase activity	CLCA4 USP11 PARL MMP21 ADAM29 MMP16 MMP19	2.55e-03	430	86	7	GO:0004175
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH3 DNAH17	2.68e-03	18	86	2	GO:0008569
GeneOntologyMolecularFunction	histone modifying activity	PRMT6 ATXN3L PRMT8 ATR ATXN3	3.11e-03	229	86	5	GO:0140993
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	ATXN3L ATXN3	3.65e-03	21	86	2	GO:1990380
GeneOntologyMolecularFunction	phospholipid transporter activity	TMEM30B ATP8A2 ATP10A	4.01e-03	74	86	3	GO:0005548
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1E CACNB3 CACNB4 KCNH5	4.23e-03	152	86	4	GO:0022843
GeneOntologyMolecularFunction	histone deacetylase activity	ATXN3L ATXN3	4.76e-03	24	86	2	GO:0004407
GeneOntologyMolecularFunction	protein lysine deacetylase activity	ATXN3L ATXN3	5.16e-03	25	86	2	GO:0033558
GeneOntologyMolecularFunction	protein kinase A regulatory subunit binding	ARFGEF2 ARFGEF1	5.16e-03	25	86	2	GO:0034237
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R33 TAS2R46	6.00e-03	27	86	2	GO:0033038
GeneOntologyBiologicalProcess	protein localization to cytosolic proteasome complex	ATXN3L ATXN3	1.76e-05	2	87	2	GO:1904327
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	TMEM30B ATP8A2 ATP10A	2.45e-05	14	87	3	GO:1990531
GeneOntologyCellularComponent	transporter complex	TMEM30B CACNA1E CACNB3 CACNB4 ATP8A2 GRIN2C ATP10A UNC80 ATP6V0A2 KCNH5	9.53e-05	550	87	10	GO:1990351
GeneOntologyCellularComponent	CKM complex	CDK8 CDK19	1.70e-04	5	87	2	GO:1990508
Domain	DUF1088	NBEA LRBA	1.95e-05	2	83	2	IPR010508
Domain	Ataxin-3	ATXN3L ATXN3	1.95e-05	2	83	2	IPR033865
Domain	DUF1088	NBEA LRBA	1.95e-05	2	83	2	PF06469
Domain	Pept_M10A_stromelysin-type	MMP21 MMP16 MMP19	6.58e-05	18	83	3	IPR016293
Domain	PG_binding_1	MMP21 MMP16 MMP19	9.13e-05	20	83	3	PF01471
Domain	Peptidoglycan-bd-like	MMP21 MMP16 MMP19	9.13e-05	20	83	3	IPR002477
Domain	DUF1981	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	PF09324
Domain	VDCC_L_bsu	CACNB3 CACNB4	1.16e-04	4	83	2	IPR000584
Domain	JOSEPHIN	ATXN3L ATXN3	1.16e-04	4	83	2	PS50957
Domain	Sec7_N	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	IPR032691
Domain	Josephin	ATXN3L ATXN3	1.16e-04	4	83	2	IPR006155
Domain	Sec7_N	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	PF12783
Domain	VGCC_beta4Aa_N	CACNB3 CACNB4	1.16e-04	4	83	2	PF12052
Domain	DCB_dom	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	IPR032629
Domain	-	MMP21 MMP19	1.16e-04	4	83	2	1.10.101.10
Domain	Josephin	ATXN3L ATXN3	1.16e-04	4	83	2	PF02099
Domain	DCB	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	PF16213
Domain	Josephin	ATXN3L ATXN3	1.16e-04	4	83	2	SM01246
Domain	Sec7_C	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	IPR015403
Domain	Hemopexin-like_dom	MMP21 MMP16 MMP19	1.41e-04	23	83	3	IPR000585
Domain	Hemopexin-like_repeat	MMP21 MMP16 MMP19	1.41e-04	23	83	3	IPR018487
Domain	M10A_MMP	MMP21 MMP16 MMP19	1.41e-04	23	83	3	IPR033739
Domain	Hemopexin	MMP21 MMP16 MMP19	1.41e-04	23	83	3	PF00045
Domain	HEMOPEXIN	MMP21 MMP16 MMP19	1.41e-04	23	83	3	PS00024
Domain	-	MMP21 MMP16 MMP19	1.41e-04	23	83	3	2.110.10.10
Domain	HEMOPEXIN_2	MMP21 MMP16 MMP19	1.41e-04	23	83	3	PS51642
Domain	HX	MMP21 MMP16 MMP19	1.41e-04	23	83	3	SM00120
Domain	Pept_M10A	MMP21 MMP16 MMP19	1.41e-04	23	83	3	IPR021190
Domain	Peptidase_M10	MMP21 MMP16 MMP19	1.60e-04	24	83	3	PF00413
Domain	DUF4704	NBEA LRBA	1.93e-04	5	83	2	IPR031570
Domain	DUF4704	NBEA LRBA	1.93e-04	5	83	2	PF15787
Domain	ZnMc	MMP21 MMP16 MMP19	2.84e-04	29	83	3	SM00235
Domain	Peptidase_Metallo	MMP21 MMP16 MMP19	2.84e-04	29	83	3	IPR006026
Domain	Pectin_lyas_fold	FBXO10 PKHD1	2.89e-04	6	83	2	IPR012334
Domain	PbH1	FBXO10 PKHD1	2.89e-04	6	83	2	SM00710
Domain	PH_BEACH	NBEA LRBA	2.89e-04	6	83	2	PF14844
Domain	-	FBXO10 PKHD1	2.89e-04	6	83	2	2.160.20.10
Domain	PbH1	FBXO10 PKHD1	2.89e-04	6	83	2	IPR006626
Domain	MetalloPept_cat_dom	MMP21 ADAM29 MMP16 MMP19	4.65e-04	81	83	4	IPR024079
Domain	-	MMP21 ADAM29 MMP16 MMP19	4.65e-04	81	83	4	3.40.390.10
Domain	PH-BEACH_dom	NBEA LRBA	5.37e-04	8	83	2	IPR023362
Domain	-	NBEA LRBA	5.37e-04	8	83	2	2.30.29.40
Domain	PH_BEACH	NBEA LRBA	5.37e-04	8	83	2	PS51783
Domain	Pectin_lyase_fold/virulence	FBXO10 PKHD1	5.37e-04	8	83	2	IPR011050
Domain	EGF_CA	THBS2 SUSD1 LRP2 LRP4	5.84e-04	86	83	4	PF07645
Domain	BEACH_dom	NBEA LRBA	6.88e-04	9	83	2	IPR000409
Domain	BEACH	NBEA LRBA	6.88e-04	9	83	2	PS50197
Domain	Beach	NBEA LRBA	6.88e-04	9	83	2	PF02138
Domain	-	NBEA LRBA	6.88e-04	9	83	2	1.10.1540.10
Domain	SAM_MT_PRMT	PRMT6 PRMT8	6.88e-04	9	83	2	PS51678
Domain	Beach	NBEA LRBA	6.88e-04	9	83	2	SM01026
Domain	Arg_MeTrfase	PRMT6 PRMT8	6.88e-04	9	83	2	IPR025799
Domain	ARM-type_fold	ATR ARFGEF2 ARFGEF1 NBEA TAF2 LRBA ITPR2	7.77e-04	339	83	7	IPR016024
Domain	CYSTEINE_SWITCH	MMP21 MMP16 MMP19	7.99e-04	41	83	3	PS00546
Domain	Pept_M10_metallopeptidase	MMP21 MMP16 MMP19	9.19e-04	43	83	3	IPR001818
Domain	ZINC_PROTEASE	MMP21 ADAM29 MMP16 MMP19	9.54e-04	98	83	4	PS00142
Domain	P_typ_ATPase_c	ATP8A2 ATP10A	1.72e-03	14	83	2	IPR032630
Domain	P-type_ATPase_N	ATP8A2 ATP10A	1.72e-03	14	83	2	IPR032631
Domain	Ldl_recept_b	LRP2 LRP4	1.72e-03	14	83	2	PF00058
Domain	LDLRB	LRP2 LRP4	1.72e-03	14	83	2	PS51120
Domain	P-type_ATPase_IV	ATP8A2 ATP10A	1.72e-03	14	83	2	IPR006539
Domain	PhoLip_ATPase_C	ATP8A2 ATP10A	1.72e-03	14	83	2	PF16212
Domain	PhoLip_ATPase_N	ATP8A2 ATP10A	1.72e-03	14	83	2	PF16209
Domain	-	ARFGEF2 ARFGEF1	1.97e-03	15	83	2	1.10.1000.11
Domain	Sec7	ARFGEF2 ARFGEF1	1.97e-03	15	83	2	PF01369
Domain	Sec7_alpha_orthog	ARFGEF2 ARFGEF1	1.97e-03	15	83	2	IPR023394
Domain	LY	LRP2 LRP4	1.97e-03	15	83	2	SM00135
Domain	LDLR_classB_rpt	LRP2 LRP4	1.97e-03	15	83	2	IPR000033
Domain	EGF_CA	THBS2 SUSD1 LRP2 LRP4	2.14e-03	122	83	4	SM00179
Domain	Sec7	ARFGEF2 ARFGEF1	2.25e-03	16	83	2	SM00222
Domain	SEC7	ARFGEF2 ARFGEF1	2.25e-03	16	83	2	PS50190
Domain	Sec7_dom	ARFGEF2 ARFGEF1	2.25e-03	16	83	2	IPR000904
Domain	EGF-like_Ca-bd_dom	THBS2 SUSD1 LRP2 LRP4	2.27e-03	124	83	4	IPR001881
Domain	UIM	ATXN3L ATXN3	2.85e-03	18	83	2	PF02809
Domain	PH_dom-like	CNKSR1 ARHGAP24 MYO7B APBB2 NBEA LRBA MPRIP	2.86e-03	426	83	7	IPR011993
Domain	UIM	ATXN3L ATXN3	3.88e-03	21	83	2	SM00726
Domain	FE2OG_OXY	ALKBH1 P4HA3	3.88e-03	21	83	2	PS51471
Domain	EGF_3	THBS2 SUSD1 LRP2 LRP4 ADAM29	3.96e-03	235	83	5	PS50026
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1E CACNB3 CACNB4	1.50e-05	11	65	3	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1E CACNB3 CACNB4	1.50e-05	11	65	3	M26913
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1E CACNB3 CACNB4	2.00e-04	25	65	3	M47948
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP21 MMP16 MMP19	3.14e-04	29	65	3	MM15981
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP21 MMP16 MMP19	3.48e-04	30	65	3	M39652
Pathway	WP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL	CACNB3 CACNB4 MAOB GABBR1	3.53e-04	73	65	4	MM16641
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1E CACNB3 CACNB4	1.56e-07	5	88	3	8825650
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1E CACNB3 CACNB4 ITPR2	2.64e-06	38	88	4	30786075
Pubmed	Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function.	CACNB3 CACNB4	6.33e-06	2	88	2	17028169
Pubmed	N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation.	ATXN3L ATXN3	6.33e-06	2	88	2	21653538
Pubmed	Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4.	CACNB3 CACNB4	6.33e-06	2	88	2	19755851
Pubmed	Mediator kinase inhibition further activates super-enhancer-associated genes in AML.	CDK8 CDK19	6.33e-06	2	88	2	26416749
Pubmed	The genomic structure and expression of MJD, the Machado-Joseph disease gene.	ATXN3L ATXN3	6.33e-06	2	88	2	11450850
Pubmed	Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).	ATXN3L ATXN3	6.33e-06	2	88	2	14661975
Pubmed	CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.	CDK8 CDK19	6.33e-06	2	88	2	28855340
Pubmed	YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.	ATXN3L ATXN3	6.33e-06	2	88	2	11978767
Pubmed	Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties.	ATXN3L ATXN3	6.33e-06	2	88	2	21060878
Pubmed	Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.	CDK8 CDK19	6.33e-06	2	88	2	35181333
Pubmed	Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.	ATXN3L ATXN3	6.33e-06	2	88	2	17488727
Pubmed	Regulatory functions of the Mediator kinases CDK8 and CDK19.	CDK8 CDK19	6.33e-06	2	88	2	30585107
Pubmed	Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.	ATXN3L ATXN3	6.33e-06	2	88	2	17764659
Pubmed	The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models.	ATXN3L ATXN3	6.33e-06	2	88	2	28676741
Pubmed	Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3.	ATXN3L ATXN3	6.33e-06	2	88	2	37122622
Pubmed	Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.	ATXN3L ATXN3	6.33e-06	2	88	2	30231063
Pubmed	Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.	ATXN3L ATXN3	6.33e-06	2	88	2	23955261
Pubmed	Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.	CDK8 CDK19	6.33e-06	2	88	2	27678455
Pubmed	Presynaptic Excitation via GABAB Receptors in Habenula Cholinergic Neurons Regulates Fear Memory Expression.	CACNA1E GABBR1	6.33e-06	2	88	2	27426949
Pubmed	Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.	ATXN3L ATXN3	6.33e-06	2	88	2	30576445
Pubmed	HIV Transcription Is Independent of Mediator Kinases.	CDK8 CDK19	6.33e-06	2	88	2	31044597
Pubmed	CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.	CDK8 CDK19	6.33e-06	2	88	2	36006697
Pubmed	Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.	ATXN3L ATXN3	6.33e-06	2	88	2	12914917
Pubmed	Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.	ATXN3L ATXN3	6.33e-06	2	88	2	20064935
Pubmed	ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.	ATR MLH1	6.33e-06	2	88	2	15282542
Pubmed	A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.	ATXN3L ATXN3	6.33e-06	2	88	2	17632007
Pubmed	Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3.	ATXN3L ATXN3	6.33e-06	2	88	2	30364204
Pubmed	Basal and stress-induced Hsp70 are modulated by ataxin-3.	ATXN3L ATXN3	6.33e-06	2	88	2	22777893
Pubmed	Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.	ATXN3L ATXN3	6.33e-06	2	88	2	17626202
Pubmed	Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.	ATXN3L ATXN3	6.33e-06	2	88	2	22843411
Pubmed	CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.	CDK8 CDK19	6.33e-06	2	88	2	37378433
Pubmed	Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3.	ATXN3L ATXN3	6.33e-06	2	88	2	36875652
Pubmed	PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.	ATXN3L ATXN3	6.33e-06	2	88	2	18668148
Pubmed	Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model.	ATXN3L ATXN3	6.33e-06	2	88	2	34220448
Pubmed	The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.	ATXN3L ATXN3	6.33e-06	2	88	2	24683430
Pubmed	Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo.	ATXN3L ATXN3	6.33e-06	2	88	2	8640226
Pubmed	Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	23918382
Pubmed	A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.	ATXN3L ATXN3	6.33e-06	2	88	2	25301414
Pubmed	Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.	ATXN3L ATXN3	6.33e-06	2	88	2	19666135
Pubmed	Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models.	ATXN3L ATXN3	6.33e-06	2	88	2	22337953
Pubmed	Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death.	ATXN3L ATXN3	6.33e-06	2	88	2	20637808
Pubmed	A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes.	ATXN3L ATXN3	6.33e-06	2	88	2	34716557
Pubmed	Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	17360629
Pubmed	Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	10716990
Pubmed	Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.	ATXN3L ATXN3	6.33e-06	2	88	2	23626768
Pubmed	Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.	CDK8 CDK19	6.33e-06	2	88	2	32560467
Pubmed	Polyglutamine-induced neurodegeneration in SCA3 is not mitigated by non-expanded ataxin-3: conclusions from double-transgenic mouse models.	ATXN3L ATXN3	6.33e-06	2	88	2	20079840
Pubmed	Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	18203920
Pubmed	A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.	ATXN3L ATXN3	6.33e-06	2	88	2	25320121
Pubmed	The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.	ATXN3L ATXN3	6.33e-06	2	88	2	33176149
Pubmed	Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture.	ATXN3L ATXN3	6.33e-06	2	88	2	36010688
Pubmed	Study of subcellular localization and proteolysis of ataxin-3.	ATXN3L ATXN3	6.33e-06	2	88	2	18353661
Pubmed	Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	10212200
Pubmed	Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology.	ATXN3L ATXN3	6.33e-06	2	88	2	23242710
Pubmed	[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].	CDK8 CDK19	6.33e-06	2	88	2	20408451
Pubmed	Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.	ATXN3L ATXN3	6.33e-06	2	88	2	23349684
Pubmed	Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.	ATXN3L ATXN3	6.33e-06	2	88	2	18502140
Pubmed	Ataxin-3 is subject to autolytic cleavage.	ATXN3L ATXN3	6.33e-06	2	88	2	16939621
Pubmed	Impaired Oligodendrocyte Maturation Is an Early Feature in SCA3 Disease Pathogenesis.	ATXN3L ATXN3	6.33e-06	2	88	2	35042771
Pubmed	Neurodegenerative phosphoprotein signaling landscape in models of SCA3.	ATXN3L ATXN3	6.33e-06	2	88	2	33741019
Pubmed	Identification of target genes for the CDK subunits of the Mediator complex.	CDK8 CDK19	6.33e-06	2	88	2	22117896
Pubmed	Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	18417613
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1E CACNB3 CACNB4	6.97e-06	15	88	3	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1E CACNB3 CACNB4	6.97e-06	15	88	3	24453333
Pubmed	Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics.	MAOB LRTM2 GABBR1	8.56e-06	16	88	3	35615067
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	GALNTL6 DNAH3 FBXO10 TLR3 PKHD1 LRP2 NBEA BRD3 FAM227B ITPR2	1.73e-05	736	88	10	29676528
Pubmed	Mouse ataxin-3 functional knock-out model.	ATXN3L ATXN3	1.90e-05	3	88	2	20945165
Pubmed	Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.	ATXN3L ATXN3	1.90e-05	3	88	2	25143392
Pubmed	Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).	ATXN3L ATXN3	1.90e-05	3	88	2	23100324
Pubmed	Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	19332778
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	1.90e-05	3	88	2	28814779
Pubmed	Specific functions of BIG1 and BIG2 in endomembrane organization.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	20360857
Pubmed	Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.	CDK8 CDK19	1.90e-05	3	88	2	26002960
Pubmed	AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	16866877
Pubmed	Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex.	CACNB3 CACNB4	1.90e-05	3	88	2	16525042
Pubmed	Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.	ATXN3L ATXN3	1.90e-05	3	88	2	15664989
Pubmed	Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.	ATXN3L ATXN3	1.90e-05	3	88	2	26505994
Pubmed	Genetic analysis of SCA 2 and 3 repeat expansions in essential tremor and atypical Parkinsonism.	ATXN3L ATXN3	1.90e-05	3	88	2	17712857
Pubmed	Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes.	ATXN3L ATXN3	1.90e-05	3	88	2	28854700
Pubmed	CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1.	ATXN3L ATXN3	1.90e-05	3	88	2	7874163
Pubmed	ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3.	ATXN3L ATXN3	1.90e-05	3	88	2	29802126
Pubmed	A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	18832381
Pubmed	Genomic structure, promoter activity, and developmental expression of the mouse homologue of the Machado-Joseph disease (MJD) gene.	ATXN3L ATXN3	1.90e-05	3	88	2	15233999
Pubmed	Expanding our understanding of polyglutamine diseases through mouse models.	ATXN3L ATXN3	1.90e-05	3	88	2	10595501
Pubmed	Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	31199673
Pubmed	Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels.	CACNB3 CACNB4	1.90e-05	3	88	2	15170217
Pubmed	Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.	ATXN3L ATXN3	1.90e-05	3	88	2	22761419
Pubmed	Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.	ATXN3L ATXN3	1.90e-05	3	88	2	26490332
Pubmed	Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	18003980
Pubmed	Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	27162341
Pubmed	The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	23386609
Pubmed	Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.	CACNB3 CACNB4	1.90e-05	3	88	2	22737983
Pubmed	Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.	CDK8 CDK19	1.90e-05	3	88	2	28151579
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP21 MMP16 MMP19	2.33e-05	22	88	3	23421805
Pubmed	Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype.	ATXN3L ATXN3	3.79e-05	4	88	2	16099943
Pubmed	Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR).	ATXN3L ATXN3	3.79e-05	4	88	2	16432517
Pubmed	Proteotoxic stress increases nuclear localization of ataxin-3.	ATXN3L ATXN3	3.79e-05	4	88	2	19843543
Pubmed	Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks.	GABBR1 ITPR2	3.79e-05	4	88	2	28012274
GeneFamily	Ataxins\|MJD deubiquinating enzymes	ATXN3L ATXN3	6.69e-05	4	61	2	997
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP21 MMP16 MMP19	7.03e-05	24	61	3	891
GeneFamily	Calcium voltage-gated channel subunits	CACNA1E CACNB3 CACNB4	8.99e-05	26	61	3	253
GeneFamily	Protein arginine methyltransferases	PRMT6 PRMT8	3.97e-04	9	61	2	691
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LRBA	3.97e-04	9	61	2	1230
GeneFamily	Low density lipoprotein receptors	LRP2 LRP4	8.53e-04	13	61	2	634
GeneFamily	ATPase phospholipid transporting	ATP8A2 ATP10A	1.14e-03	15	61	2	1210
GeneFamily	Dyneins, axonemal	DNAH3 DNAH17	1.47e-03	17	61	2	536
GeneFamily	Cyclin dependent kinases	CDK8 CDK19	3.45e-03	26	61	2	496
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	CACNB3 CACNB4	3.45e-03	26	61	2	904
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	ARFGEF2 NBEA	4.29e-03	29	61	2	396
GeneFamily	Cyclins\|Mediator complex	CDK8 CDK19	5.53e-03	33	61	2	1061
GeneFamily	Taste 2 receptors	TAS2R33 TAS2R46	7.66e-03	39	61	2	1162
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SUSD1 GABBR1	1.59e-02	57	61	2	1179
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GALNTL6 CACNA1E DNAH3 ATP8A2 LRP2 KCNH5	9.41e-07	167	87	6	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNTL6 TRANK1 MYO7B PKHD1 LRP2 UNC80	1.65e-06	184	87	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNTL6 TRANK1 MYO7B PKHD1 LRP2 UNC80	1.65e-06	184	87	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNTL6 TRANK1 MYO7B PKHD1 LRP2 UNC80	1.65e-06	184	87	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNB4 ATP8A2 SYNE1 NBEA MMP16 UNC80	2.53e-06	198	87	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SYNE1 PKHD1 MMP21 PCNX1 LRBA	6.85e-06	135	87	5	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	Severe-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYO7B TCL1A APBB2 CHD3 LRTM2	9.69e-06	145	87	5	a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNTL6 ATXN3L ATP8A2 ADAM29 KCNH5	1.14e-05	150	87	5	0205318a870e091add66ee4305747dda9f51510d
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	GALNTL6 CPA6 DNAH3 ATP8A2 KCNH5	1.51e-05	159	87	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	GALNTL6 DNAH3 ATP8A2 ADAM29 KCNH5	1.71e-05	163	87	5	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	normal-na-Lymphocytic_T-T4_reg-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CPA6 PRMT8 SLC35F2 CHD3 LRBA	1.71e-05	163	87	5	43887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CPA6 P4HA3 SLC35F2 VARS1 GABBR1	1.92e-05	167	87	5	b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPA6 SYNE1 APBB2 NBEA MMP16	2.09e-05	170	87	5	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPA6 SYNE1 APBB2 NBEA MMP16	2.09e-05	170	87	5	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SUSD1 DNAH17 SLC35F2 CHD3 CMAHP	2.47e-05	176	87	5	218a072882d387adbbad6916d7214099c7354465
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4\|TCGA-Uvea / Sample_Type by Project: Shred V9	THBS2 SAMD8 ARFGEF1 TAF2 ITPR2	3.05e-05	184	87	5	9c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_P2ry12\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	THBS2 ANKRD60 RIPK4 ATP10A	3.07e-05	91	87	4	3f56358ff0dacdf6b8fc22cea64082231bceb851
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	CPA6 TMEM245 APBB2 LRP4 ITPR2	3.21e-05	186	87	5	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	CPA6 TMEM245 APBB2 LRP4 ITPR2	3.21e-05	186	87	5	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPA6 SYNE1 APBB2 MMP16 ATP10A	3.30e-05	187	87	5	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPA6 SYNE1 APBB2 MMP16 ATP10A	3.30e-05	187	87	5	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPA6 SYNE1 APBB2 MMP16 ATP10A	3.38e-05	188	87	5	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TMEM30B PRMT8 PKHD1 LRP2 RIPK4	3.47e-05	189	87	5	c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TMEM30B PRMT8 PKHD1 LRP2 RIPK4	3.56e-05	190	87	5	c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TMEM30B PRMT8 PKHD1 LRP2 RIPK4	3.65e-05	191	87	5	72dbd2e0fabfca8d6f604df35277d3574739a0b3
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PRMT8 TRANK1 UNC80 KCNH5	3.83e-05	193	87	5	461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PRMT8 TRANK1 UNC80 KCNH5	3.83e-05	193	87	5	0dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCell	PCW_05-06-Epithelial-Epithelial_airway\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TMEM30B PRMT8 PKHD1 LRP2 RIPK4	3.83e-05	193	87	5	af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCell	P28-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFB3 CACNA1E THBS2 MAOB P4HA3	3.93e-05	194	87	5	3c661c6768c3f05d2aba03d329adb257ca201b2d
ToppCell	PCW_05-06-Epithelial\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TMEM30B PRMT8 PKHD1 LRP2 RIPK4	3.93e-05	194	87	5	47a1369c22fcbfe00b08376eb610a61c355548db
ToppCell	PCW_07-8.5-Epithelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TMEM30B PRMT8 PKHD1 LRP2 RIPK4	3.93e-05	194	87	5	f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNB4 ATP8A2 SYNE1 NBEA UNC80	4.12e-05	196	87	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNB4 ATP8A2 SYNE1 NBEA UNC80	4.33e-05	198	87	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNB4 ATP8A2 SYNE1 NBEA UNC80	4.33e-05	198	87	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNB4 ATP8A2 SYNE1 NBEA UNC80	4.33e-05	198	87	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNB4 ATP8A2 SYNE1 NBEA UNC80	4.54e-05	200	87	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Mesenchymal\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	CPA6 ARHGAP24 SUSD1 IDUA UNC80	4.54e-05	200	87	5	e5b7d9622b96bb20c81ac76b4e60e8b44fa9cca1
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_naive\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GALNTL6 GANC MYO7B TCL1A	4.61e-05	101	87	4	86acaa2502f61baa714ae988b73e3e73a71e897e
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB4 NECAB2 LRP2 LRP4	1.12e-04	127	87	4	6b24630978eb0772b4cd3bf59e5bc4390be47619
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFB3 ARFGEF2 F2RL2 KCNH5	2.19e-04	151	87	4	29d91a7d1470121af45fb8bb35175f2acced4551
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFB3 ARFGEF2 F2RL2 KCNH5	2.19e-04	151	87	4	9ebfbdccc9656fce8990d06622f225009633f07c
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1E SUSD1 CMAHP VARS1	2.24e-04	152	87	4	b750302d442160a1007659c2386ac90282bf95d2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPA6 CACNB3 CLEC6A CHD3	2.41e-04	155	87	4	72a19a9ecfd13f6769c4b447d3ce01a855ec6ec7
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BTBD8 GANC ATP8A2 PKHD1	2.47e-04	156	87	4	58b9520fce6e259b36c3d59e82b712f5e7729e3e
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CACNB4 CLEC6A SELENOI MMP19	2.54e-04	157	87	4	f896997490bb2eec598c6581f161220e70f9a991
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CACNB4 CLEC6A SELENOI MMP19	2.54e-04	157	87	4	14a8516346a89a89f1119b744625bd9844a74a03
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLEC6A MMP21 MMP19 ATP10A	2.60e-04	158	87	4	6811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLH1 SLC35F2 IDUA ATP6V0A2	2.60e-04	158	87	4	1d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPA6 SYNE1 NBEA MMP16	2.66e-04	159	87	4	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B PKHD1 LRP2 UNC80	2.73e-04	160	87	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B PKHD1 LRP2 UNC80	2.73e-04	160	87	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPA6 CLEC6A MAOB P4HA3	2.79e-04	161	87	4	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLEC6A MMP21 MMP19 ATP10A	2.86e-04	162	87	4	d712bc31840ad1523e3dbf884acbb428a8995001
ToppCell	normal_Lymph_Node-B_lymphocytes-Undetermined\|normal_Lymph_Node / Location, Cell class and cell subclass	ARHGAP24 TCL1A TAS2R46 F2RL2	2.86e-04	162	87	4	91ac35ae7fde411cd6a44e715a33dac62419cab8
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E SUSD1 CMAHP VARS1	3.13e-04	166	87	4	3e3e9296e6919a38602e417a6606c046af3bd101
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CACNB3 MAOB APBB2 ITPR2	3.21e-04	167	87	4	49d9220f22d10ff06c0512c9c40c26ad51728e4f
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CACNB3 MAOB APBB2 ITPR2	3.21e-04	167	87	4	7ec032a98a13504d15c7e3a4e259278d07f40180
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E SUSD1 CMAHP VARS1	3.21e-04	167	87	4	3c3e1c31aacca48099693aea2efdfa22fc0e4af4
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1E ATP8A2 MMP16 UNC80	3.21e-04	167	87	4	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CACNB3 MAOB APBB2 ITPR2	3.21e-04	167	87	4	5e3588eee73693a996bb4846427cf0038ceafbca
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E SUSD1 CMAHP VARS1	3.21e-04	167	87	4	77a4d7ce44847c76074d4f5340d61b398fe43e6c
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	MAOB ATP8A2 NBEA ATP6V0A2	3.35e-04	169	87	4	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1E ATP8A2 MMP16 UNC80	3.35e-04	169	87	4	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRANK1 PKHD1 LRP2 UNC80	3.35e-04	169	87	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	MAOB ATP8A2 NBEA ATP6V0A2	3.43e-04	170	87	4	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-mature_NK_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GVINP1 ATP8A2 SLC35F2 F2RL2	3.51e-04	171	87	4	d322cc042a6f4b4aa8ef80ae977edbce9e266d48
ToppCell	356C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SAMD8 DNAH17 IDUA MMP19	3.51e-04	171	87	4	3d26ef58fe5231373d7df9ac79d225546918cf82
ToppCell	356C-Lymphocytic-ILC-ILC-2\|ILC / Donor, Lineage, Cell class and subclass (all cells)	SAMD8 DNAH17 IDUA MMP19	3.59e-04	172	87	4	4977e1f4deae781750e27a8054deccd336cfb74a
ToppCell	Severe-B_naive-8\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYO7B TCL1A APBB2 CHD3	3.75e-04	174	87	4	f3f8c924420f46321bd47e2b97f18c7241541599
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB3 CACNB4 GRIN2C PAPOLG	3.83e-04	175	87	4	91cb819a1786020713b7e64480de0545380daae9
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E THBS2 GANC ATP8A2	3.83e-04	175	87	4	9d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1E CLCA4 BTBD8 UNC80	3.83e-04	175	87	4	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1E CLCA4 BTBD8 UNC80	3.83e-04	175	87	4	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E THBS2 GANC ATP8A2	3.83e-04	175	87	4	f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCell	droplet-Lung-LUNG-30m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM30B PRMT8 PKHD1 LRP2	3.91e-04	176	87	4	5201f003192c033655ba47f0faf8c47a96eae03d
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNB3 CACNB4 GRIN2C PAPOLG	4.00e-04	177	87	4	4672cc75225a4a23b298afa8ce439628262519db
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	SAMD8 SYNE1 GABBR1 MPRIP	4.00e-04	177	87	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	droplet-Lung-30m-Epithelial-alveolar_epithelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM30B PRMT8 MAOB LRP2	4.08e-04	178	87	4	76e71fff99cf64302e2e3c0d66dd8ba0ff13624e
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	THBS2 SYNE1 P4HA3 MMP19	4.08e-04	178	87	4	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	droplet-Lung-30m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM30B PRMT8 MAOB LRP2	4.08e-04	178	87	4	82f78ea1ea3ff3e2347cd8bc2f06e2a10e96f220
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-1\|TCGA-Liver / Sample_Type by Project: Shred V9	CACNB3 ATP8A2 PKHD1 SLC35F2	4.08e-04	178	87	4	51c59dabf2d7aef1b1964f6f766d5ec07ef90f5a
ToppCell	droplet-Lung-30m-Epithelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM30B PRMT8 MAOB LRP2	4.08e-04	178	87	4	5442bc52b8e902da1383f44d97a9f95e471a8d4d
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	MYO7B TCL1A APBB2 CHD3	4.08e-04	178	87	4	71ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCell	droplet-Lung-30m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM30B PRMT8 MAOB LRP2	4.08e-04	178	87	4	523b286ebe0359c7f1902f28cbd71f452626fc0d
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SYNE1 P4HA3 MMP19 ATP10A	4.17e-04	179	87	4	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BTBD8 SYNE1 CMAHP F2RL2	4.26e-04	180	87	4	ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 NECAB2 TLR3 LRTM2	4.26e-04	180	87	4	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E MYO7B PKHD1 LRP2	4.26e-04	180	87	4	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BTBD8 SYNE1 CMAHP F2RL2	4.26e-04	180	87	4	4e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 NECAB2 TLR3 LRTM2	4.26e-04	180	87	4	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BTBD8 SYNE1 CMAHP F2RL2	4.26e-04	180	87	4	466381bf93c3da6a2a241daadb68e9aad2964eae
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E MYO7B PKHD1 LRP2	4.35e-04	181	87	4	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PRMT8 NECAB2 TRANK1	4.44e-04	182	87	4	d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TRANK1 PCNX1 CHD3 MPRIP	4.44e-04	182	87	4	1aea96ee211f7b9caef7fd385233f51be6021a73
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNB4 ARHGAP24 APBB2 LRBA	4.44e-04	182	87	4	5f513bbb7125956eb528e3120de3fd776770a7c3
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP24 SUSD1 ARFGEF2 ARFGEF1	4.44e-04	182	87	4	03992d0ae519795239e4f2cc8e63f33c4482de6a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PRMT8 NECAB2 TRANK1	4.44e-04	182	87	4	6cde859edfe7607bd7ada89d20258413d06f4207
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TRANK1 PCNX1 CHD3 MPRIP	4.44e-04	182	87	4	b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TRANK1 PCNX1 CHD3 MPRIP	4.44e-04	182	87	4	c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TRANK1 PCNX1 CHD3 MPRIP	4.44e-04	182	87	4	4cb182ef39be2044a6ad7266f332d4177591e550
Disease	Intellectual Disability	CDK8 CACNA1E CNKSR1 ATP8A2 SYNE1 LRP2 NBEA CHD3 TAF2	5.77e-06	447	85	9	C3714756
Disease	developmental and epileptic encephalopathy 87 (implicated_via_orthology)	CDK8 CDK19	8.20e-06	2	85	2	DOID:0112221 (implicated_via_orthology)
Disease	Global developmental delay	CDK8 CACNA1E NBEA CHD3 DEGS1	4.24e-05	133	85	5	C0557874
Disease	Machado-Joseph disease (implicated_via_orthology)	ATXN3L ATXN3	4.90e-05	4	85	2	DOID:1440 (implicated_via_orthology)
Disease	Seizures	CDK8 CACNA1E FKTN NBEA DEGS1	4.27e-04	218	85	5	C0036572
Disease	Macrocephaly	CACNA1E CHD3	4.44e-04	11	85	2	C0221355
Disease	biological sex	GALNTL6 CACNB4 PKHD1 MMP16 GABBR1	5.44e-04	230	85	5	PATO_0000047
Disease	Tinnitus	PKHD1 ADAM29 ATP10A KCNH5	5.53e-04	130	85	4	HP_0000360
Disease	amino acid measurement	CDK8 GALNTL6 SUSD1 SYNE1 PARL LRP2 LRBA CMAHP	7.58e-04	678	85	8	EFO_0005134
Disease	response to phenylephrine	F2RL2 ATP10A	1.08e-03	17	85	2	EFO_0010152
Disease	muscular dystrophy (is_implicated_in)	FKTN SYNE1	1.08e-03	17	85	2	DOID:9884 (is_implicated_in)
Disease	aspartate aminotransferase measurement	BTBD8 SLC35F2 BRD3 FAM227B LRBA ST7L CMAHP VARS1 GABBR1	1.18e-03	904	85	9	EFO_0004736
Disease	Malignant neoplasm of endometrium	ATR MLH1	1.22e-03	18	85	2	C0007103
Disease	Carcinoma in situ of endometrium	ATR MLH1	1.22e-03	18	85	2	C0346191
Disease	Alzheimer disease, polygenic risk score	CACNA1E ARHGAP24 TMEM245 PKHD1 P4HA3 LRBA GABBR1	1.52e-03	586	85	7	EFO_0030082, MONDO_0004975
Disease	short-term memory	PRMT6 GALNTL6 TCL1A	1.80e-03	83	85	3	EFO_0004335

Protein segments in the cluster

Peptide	Gene	Start	Entry
QNGFWTLEMHKRKYW	BTN2A3P	386	Q96KV6
KQSSYVGWWIHFRIV	ADAM29	186	Q9UKF5
KFQNWDYWPREIHFR	FAM227B	31	Q96M60
VVKTLWKHQFAWPFY	BRD3	46	Q15059
LHRWFGSFFTLKWED	ERVK11-1	166	P61568
WKRVSDIAGTYYWHI	APBB2	296	Q92870
RKVWLLFDYAEHDLW	CDK19	91	Q9BWU1
DFLHIKEKYSNDWWI	CACNB3	91	P54284
REWKRHEFHYDNIIW	CACNA1E	1346	Q15878
EKLRWVTVGYHYNWD	ALKBH1	166	Q13686
GHTYEKHWWQDLFRI	ARFGEF1	1416	Q9Y6D6
LYWKWFVSHFRSNLE	GVINP1	2376	Q7Z2Y8
WREAFKQHYLASKTW	FBXO10	71	Q9UK96
FEKHWWQDLFRIVFR	ARFGEF2	1366	Q9Y6D5
KWKHWTSQRAFVALY	ANKRD60	211	Q9BZ19
IEDRQYKDFKIHWWE	PRMT8	226	Q9NR22
DGYHFSWTNDRFWRK	CPA6	241	Q8N4T0
LHIKEKYNNDWWIGR	CACNB4	126	O00305
LYWNRSHGEKNWYIK	ATP8A2	336	Q9NTI2
VGHGLWIWRYQEKKS	ATP10A	326	O60312
RYFNEHWKEEFTWLD	C17orf113	21	A0A1B0GUU1
NEGSWFYIHPFWKLR	ITPR2	156	Q14571
LVGDKWVANKWIHEY	P4HA3	516	Q7Z4N8
WVANKWIHEYGQEFR	P4HA3	521	Q7Z4N8
ETHEVSALWFLWYVK	MAOB	176	P27338
KQYEDGQWKKHWFVL	MPRIP	396	Q6WCQ1
ERLFGKKYVWFLIGW	GABBR1	381	Q9UBS5
YKEHWFTVRKLGKQW	ATXN3	116	P54252
IILHYCAFKTTWDWV	KCNH5	206	Q8NCM2
YKQHWFTIRKFGKHW	ATXN3L	116	Q9H3M9
WFEKLHVWLLFVEKN	PCNX1	1346	Q96RV3
TQWIHFFKGDKVWRY	MMP19	346	Q99542
AFVHIWTWKRDERYF	MMP21	396	Q8N119
WLDIEHTEGKRYFTW	GANC	396	Q8TET4
ILLYHAVKYEWGGWR	LRBA	896	P50851
WVGRHIYWSDVKNKR	LRP2	4151	P98164
AYDHRWLWYVKASLL	F2RL2	291	O00254
TLVHKFFLVFSKWEW	PAPOLG	266	Q9BWT3
WHTRWFVLKGDQLYY	ARHGAP24	36	Q8N264
YVERAKWLWSKGDVH	ATR	1956	Q13535
YRVEFSKWWINEFKT	DNAH17	2371	Q9UFH2
RQWIDHGYWFDKKDT	DNAH3	2161	Q8TD57
SEREFFVKWVGLSYW	CHD3	546	Q12873
WYEKNKHIFPASRWE	FAM50A	311	Q14320
WIVKHFARFWSERSF	BTBD8	341	Q5XKL5
LDRSGIAWWTDYHVK	TMEM30B	191	Q3MIR4
GAFYIVKDLDWKWVI	DEGS1	56	O15121
VKDLDWKWVIFGAYA	DEGS1	61	O15121
LEWRLGFWSQVKQHY	PRMT6	201	Q96LA8
QYHLWKNEEGWFRIA	FKTN	116	O75072
RYGLAHVSKWNFETW	IDUA	166	P35475
WVVLFSFILSHWEKY	SELENOI	161	Q9C0D9
RKVWLLFDYAEHDLW	CDK8	91	P49336
FGIWYVTYGHELIWK	PARL	341	Q9H300
FILDWKFDRVHKWSE	RPIA	256	P49247
QFYSWTDGLRRKDWH	GALNTL6	56	Q49A17
LSVFWQVRYWVKGEK	TAS2R33	291	P0DSN6
LSVLWHVRYWVKGEK	TAS2R46	291	P59540
VWKWKEEKGDRIYHQ	VARS1	416	P26640
GWEEIKHLKSELWIY	SYNE1	4131	Q8NF91
YGSVWEKLHRAFAIW	SAMD8	266	Q96LT4
LREFKHWMEWFSYRG	LRTM2	206	Q8N967
WMKKTFGVNEYRHWI	TAF2	381	Q6P1X5
RILLYHAIKYEWGGW	NBEA	921	Q8NFP9
RYISWEAIHGRKDDW	PKHD1	2276	P08F94
IVEYKDIASIHWDWK	SLC35F2	246	Q8IXU6
SWKWTVEHIVYKALR	MLH1	711	P40692
DIFGRIIWHKFKQWV	MRPL47	171	Q9HD33
VYKVRHVHWKTWLAI	RIPK4	36	P57078
WEKFVYLDEKQHAWL	TCL1A	21	P56279
EIFLHSSWIKEYFTW	CMAHP	346	Q9Y471
WIDKTPYEKNVRFWH	CLEC6A	151	Q6EIG7
KLFVHEWAHLRWGVF	CLCA4	151	Q14CN2
RRWFVLKGHTLYWYR	CNKSR1	426	Q969H4
LLIHFEGWRISFYWN	TLR3	721	O15455
LKFHTLWRFRYQVWP	UNC80	1646	Q8N2C7
SAIWWEDVGKTYFFK	MMP16	441	P51512
YLFHIWGQRWYQKEF	SUSD1	521	Q6UWL2
ISGLIFIFEWWYFHK	ST7L	91	Q8TDW4
VPLYFTVKLHWWRFL	RNF121	91	Q9H920
VVDFLEKRYHVWWGI	TMEM245	396	Q9H330
EKRYHVWWGIIESFL	TMEM245	401	Q9H330
LELWDRLYHSWFVKN	TMEM245	561	Q9H330
NIGWKDYTAYRWHLT	THBS2	1101	P35442
LWKKFHVYWEKAEQA	TRANK1	1046	O15050
LRAGESWFLVEKHWY	USP11	96	P51784
YIDFRQDLGWKWVHE	TGFB3	321	P10600
ALFVHYINIYKTVWW	TMEM39B	91	Q9GZU3
TGEVIKWYVFLISFW	ATP6V0A2	216	Q9Y487
IAVFPRKGYLFWTDW	LRP4	1476	O75096
WRIYFRKEFFTPWHD	MYO7B	1281	Q6PIF6
LVFAWEHLVYWKLRH	GRIN2C	831	Q14957
YEFWETEEAWKRHLQ	NECAB2	336	Q7Z6G3