Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A SCN8A

2.24e-0914264GO:0031402
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN3A SCN8A

3.31e-0826264GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A SCN8A

3.31e-0826264GO:0031420
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN3A SCN8A

5.86e-0752264GO:0005272
GeneOntologyMolecularFunctionmonoatomic cation channel activity

ANO10 TRPM3 SCN1A SCN2A SCN3A SCN8A

4.24e-06343266GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

ANO10 TRPM3 SCN1A SCN2A SCN3A SCN8A

2.22e-05459266GO:0005216
GeneOntologyMolecularFunctionchannel activity

ANO10 TRPM3 SCN1A SCN2A SCN3A SCN8A

4.72e-05525266GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

ANO10 TRPM3 SCN1A SCN2A SCN3A SCN8A

4.77e-05526266GO:0022803
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN1A SCN2A SCN3A SCN8A

6.70e-05171264GO:0015081
GeneOntologyMolecularFunctiontransmembrane transporter activity

ANO10 SLCO1C1 ABCB9 TRPM3 SCN1A SCN2A SCN3A SCN8A

8.71e-051180268GO:0022857
GeneOntologyMolecularFunctiontransporter activity

ANO10 SLCO1C1 ABCB9 TRPM3 SCN1A SCN2A SCN3A SCN8A

1.61e-041289268GO:0005215
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

ANO10 TRPM3 SCN1A SCN2A SCN3A SCN8A

1.72e-04664266GO:0008324
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A

2.19e-0417262GO:0099508
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TRPM3 SCN1A SCN2A SCN3A SCN8A

2.94e-04465265GO:0046873
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

ANO10 TRPM3 SCN1A SCN2A SCN3A SCN8A

3.52e-04758266GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

ANO10 TRPM3 SCN1A SCN2A SCN3A SCN8A

4.48e-04793266GO:0015075
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TRPM3 SCN1A SCN2A SCN3A SCN8A

1.14e-03627265GO:0022890
GeneOntologyMolecularFunctiongated channel activity

ANO10 SCN1A SCN2A

9.07e-03334263GO:0022836
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN2A SCN3A SCN8A

1.14e-0736264GO:0086010
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN1A SCN2A SCN3A SCN8A

1.05e-0662264GO:0086002
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN2A SCN3A SCN8A

1.12e-0663264GO:0019228
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN1A SCN2A SCN3A SCN8A

4.11e-0687264GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN1A SCN2A SCN3A SCN8A

5.37e-0693264GO:0086003
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN1A SCN2A SCN3A SCN8A

1.12e-05112264GO:0019226
GeneOntologyBiologicalProcessmembrane depolarization

SCN1A SCN2A SCN3A SCN8A

1.52e-05121264GO:0051899
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN1A SCN2A SCN3A SCN8A

1.84e-05127264GO:0070252
GeneOntologyBiologicalProcessmonoatomic ion transport

ANO10 SLCO1C1 HTR7 TRPM3 ITGB3 SCN1A SCN2A SCN3A SCN8A

2.79e-051374269GO:0006811
GeneOntologyBiologicalProcessactin filament-based movement

SCN1A SCN2A SCN3A SCN8A

3.83e-05153264GO:0030048
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN1A SCN2A SCN3A SCN8A

5.39e-05167264GO:0060048
GeneOntologyBiologicalProcessaction potential

SCN1A SCN2A SCN3A SCN8A

1.11e-04201264GO:0001508
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

ANO10 TRPM3 ITGB3 SCN1A SCN2A SCN3A SCN8A

1.24e-04942267GO:0098655
GeneOntologyBiologicalProcessmuscle contraction

HTR7 SCN1A SCN2A SCN3A SCN8A

1.26e-04400265GO:0006936
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SCN1A SCN2A SCN3A SCN8A

1.26e-04208264GO:0035725
GeneOntologyBiologicalProcessstriated muscle contraction

SCN1A SCN2A SCN3A SCN8A

1.49e-04217264GO:0006941
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

ANO10 TRPM3 ITGB3 SCN1A SCN2A SCN3A SCN8A

2.00e-041017267GO:0098660
GeneOntologyBiologicalProcesscirculatory system process

SLCO1C1 HTR7 SCN1A SCN2A SCN3A SCN8A

2.47e-04733266GO:0003013
GeneOntologyBiologicalProcessnerve development

SCN1A SCN2A SCN8A

3.42e-04109263GO:0021675
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

ANO10 TRPM3 ITGB3 SCN1A SCN2A SCN3A SCN8A

3.51e-041115267GO:0034220
GeneOntologyBiologicalProcesssodium ion transport

SCN1A SCN2A SCN3A SCN8A

3.67e-04275264GO:0006814
GeneOntologyBiologicalProcessmonoatomic cation transport

ANO10 TRPM3 ITGB3 SCN1A SCN2A SCN3A SCN8A

4.40e-041157267GO:0006812
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception of pain

HTR7 SCN1A

4.87e-0426262GO:0050966
GeneOntologyBiologicalProcessheart contraction

SCN1A SCN2A SCN3A SCN8A

4.97e-04298264GO:0060047
GeneOntologyBiologicalProcessmuscle system process

HTR7 SCN1A SCN2A SCN3A SCN8A

5.34e-04547265GO:0003012
GeneOntologyBiologicalProcessheart process

SCN1A SCN2A SCN3A SCN8A

5.69e-04309264GO:0003015
GeneOntologyBiologicalProcessbehavior

GAD1 HTR7 SCN1A SCN2A SCN3A SCN8A

7.00e-04891266GO:0007610
GeneOntologyBiologicalProcessserotonin transport

HTR7 ITGB3

7.40e-0432262GO:0006837
GeneOntologyBiologicalProcessbehavioral response to pain

HTR7 SCN3A

7.40e-0432262GO:0048266
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

TRPM3 ITGB3 SCN1A SCN2A SCN3A SCN8A

8.37e-04922266GO:0098662
GeneOntologyBiologicalProcessvery long-chain fatty acid metabolic process

HACD4 ACOT1

8.86e-0435262GO:0000038
GeneOntologyBiologicalProcessblood circulation

HTR7 SCN1A SCN2A SCN3A SCN8A

1.15e-03648265GO:0008015
GeneOntologyBiologicalProcessmetal ion transport

TRPM3 ITGB3 SCN1A SCN2A SCN3A SCN8A

1.28e-031000266GO:0030001
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception of pain

HTR7 SCN1A

1.34e-0343262GO:0062149
GeneOntologyBiologicalProcessadult walking behavior

SCN1A SCN8A

1.80e-0350262GO:0007628
GeneOntologyBiologicalProcessresponse to pain

HTR7 SCN3A

1.88e-0351262GO:0048265
GeneOntologyBiologicalProcessmonocarboxylic acid metabolic process

GAD1 HACD4 ACOT1 DAGLA ACBD5

1.95e-03731265GO:0032787
GeneOntologyBiologicalProcessdetermination of adult lifespan

SCN1A SCN2A

2.10e-0354262GO:0008340
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

HTR7 SCN1A

2.34e-0357262GO:0050974
GeneOntologyBiologicalProcessfatty acid metabolic process

HACD4 ACOT1 DAGLA ACBD5

2.49e-03461264GO:0006631
GeneOntologyBiologicalProcesswalking behavior

SCN1A SCN8A

2.59e-0360262GO:0090659
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A SCN8A

5.19e-0917274GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN3A SCN8A

5.13e-0829274GO:0034706
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A SCN8A

2.16e-0620273GO:0033268
GeneOntologyCellularComponentmain axon

DAGLA SCN1A SCN2A SCN8A

5.00e-0689274GO:0044304
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN2A SCN8A

6.87e-0629273GO:0043194
GeneOntologyCellularComponentsynaptic membrane

HTR7 ITGB3 DAGLA SCN1A SCN2A SCN8A

8.24e-05583276GO:0097060
GeneOntologyCellularComponentaxon

GAD1 HTR7 DAGLA SCN1A SCN2A SCN3A SCN8A

1.05e-04891277GO:0030424
GeneOntologyCellularComponentcation channel complex

SCN1A SCN2A SCN3A SCN8A

2.23e-04235274GO:0034703
GeneOntologyCellularComponentpresynaptic membrane

HTR7 SCN1A SCN2A SCN8A

4.16e-04277274GO:0042734
GeneOntologyCellularComponentmonoatomic ion channel complex

SCN1A SCN2A SCN3A SCN8A

1.33e-03378274GO:0034702
GeneOntologyCellularComponentpostsynaptic membrane

HTR7 ITGB3 DAGLA SCN8A

1.71e-03405274GO:0045211
GeneOntologyCellularComponentplasma membrane protein complex

ITGB3 SCN1A SCN2A SCN3A SCN8A

2.99e-03785275GO:0098797
GeneOntologyCellularComponentintercalated disc

SCN1A SCN2A

3.47e-0368272GO:0014704
GeneOntologyCellularComponentneuronal cell body

GAD1 HTR7 SCN1A SCN3A SCN8A

3.90e-03835275GO:0043025
GeneOntologyCellularComponentsomatodendritic compartment

GAD1 HTR7 DAGLA SCN1A SCN3A SCN8A

4.14e-031228276GO:0036477
GeneOntologyCellularComponenttransmembrane transporter complex

SCN1A SCN2A SCN3A SCN8A

4.30e-03523274GO:1902495
GeneOntologyCellularComponentT-tubule

SCN1A SCN2A

4.66e-0379272GO:0030315
GeneOntologyCellularComponentpresynapse

GAD1 HTR7 SCN1A SCN2A SCN8A

5.02e-03886275GO:0098793
GeneOntologyCellularComponenttransporter complex

SCN1A SCN2A SCN3A SCN8A

5.14e-03550274GO:1990351
GeneOntologyCellularComponentcell body

GAD1 HTR7 SCN1A SCN3A SCN8A

6.12e-03929275GO:0044297
GeneOntologyCellularComponentcell-cell contact zone

SCN1A SCN2A

6.53e-0394272GO:0044291
HumanPhenoSimple febrile seizure

SCN1A SCN2A SCN3A SCN8A

4.33e-0727134HP:0011171
HumanPhenoFocal automatism seizure

SCN1A SCN2A SCN8A

2.82e-0612133HP:0032898
HumanPhenoComplex febrile seizure

SCN1A SCN2A SCN8A

7.14e-0616133HP:0011172
HumanPhenoFocal hemiclonic seizure

SCN1A SCN2A SCN8A

2.89e-0525133HP:0006813
HumanPhenoClonic seizure

SCN1A SCN2A SCN3A SCN8A

3.80e-0581134HP:0020221
HumanPhenoProgressive gait ataxia

ANO10 SCN1A SCN2A

5.07e-0530133HP:0007240
HumanPhenoProgressive ataxia

ANO10 SCN1A SCN2A

5.07e-0530133HP:0001329
HumanPhenoFocal head nodding automatism seizure

SCN2A SCN8A

5.99e-055132HP:0032906
HumanPhenoNeonatal electro-clinical non-motor seizure

SCN2A SCN8A

5.99e-055132HP:0032812
HumanPhenoNeonatal seizure with electrographic correlate

SCN2A SCN8A

5.99e-055132HP:0032808
HumanPhenoNeonatal electro-clinical seizure

SCN2A SCN8A

5.99e-055132HP:0032809
HumanPhenoNeonatal electro-clinical seizure with behavior arrest

SCN2A SCN8A

5.99e-055132HP:0032823
HumanPhenoHypsarrhythmia

GAD1 SCN1A SCN2A SCN3A SCN8A

6.08e-05185135HP:0002521
HumanPhenoGeneralized clonic seizure

SCN1A SCN2A SCN8A

7.43e-0534133HP:0011169
HumanPhenoInterictal EEG abnormality

GAD1 TRPM3 SCN1A SCN2A SCN3A SCN8A

7.54e-05325136HP:0025373
HumanPhenoNormal interictal EEG

SCN2A SCN8A

8.97e-056132HP:0002372
HumanPhenoEpileptic spasm

GAD1 TRPM3 SCN1A SCN2A SCN8A

1.04e-04207135HP:0011097
HumanPhenoHyperkinetic movements

GAD1 SCN1A SCN2A

1.22e-0440133HP:0002487
HumanPhenoFocal non-motor seizure

SCN1A SCN2A SCN8A

1.22e-0440133HP:0032679
HumanPhenoEyelid myoclonia seizure

SCN2A SCN8A

1.25e-047132HP:0032678
HumanPhenoFocal clonic seizure

SCN1A SCN2A SCN8A

1.41e-0442133HP:0002266
HumanPhenoGeneralized-onset seizure

GAD1 ANO10 TRPM3 SCN1A SCN2A SCN3A SCN8A

1.47e-04544137HP:0002197
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A

1.67e-048132HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A

1.67e-048132HP:0200048
HumanPhenoEpileptic encephalopathy

SCN1A SCN2A SCN3A SCN8A

1.72e-04119134HP:0200134
HumanPhenoChoreoathetosis

TRPM3 SCN1A SCN2A SCN8A

1.96e-04123134HP:0001266
HumanPhenoFocal impaired awareness seizure

SCN1A SCN2A SCN3A SCN8A

2.15e-04126134HP:0002384
HumanPhenoBilateral tonic-clonic seizure

GAD1 TRPM3 SCN1A SCN2A SCN3A SCN8A

2.21e-04394136HP:0002069
HumanPhenoDialeptic seizure

TRPM3 SCN1A SCN2A SCN3A SCN8A

2.59e-04251135HP:0011146
HumanPhenoBilateral tonic-clonic seizure with focal onset

SCN1A SCN2A SCN8A

2.67e-0452133HP:0007334
HumanPhenoBilateral tonic-clonic seizure with generalized onset

GAD1 SCN1A SCN2A

2.67e-0452133HP:0025190
HumanPhenoSudden unexpected death in epilepsy

SCN1A SCN8A

2.67e-0410132HP:0033258
HumanPhenoLimited neck range of motion

SCN1A SCN2A

3.26e-0411132HP:0000466
HumanPhenoNeonatal seizure

SCN2A SCN8A

3.26e-0411132HP:0032807
HumanPhenoContinuous spike and waves during slow sleep

TRPM3 SCN2A

3.26e-0411132HP:0031491
HumanPhenoEEG with generalized epileptiform discharges

GAD1 SCN1A SCN2A SCN3A SCN8A

3.65e-04270135HP:0011198
HumanPhenoInfection-related seizure

SCN1A SCN2A SCN3A SCN8A

3.69e-04145134HP:0032892
HumanPhenoSeizure precipitated by febrile infection

SCN1A SCN2A SCN3A SCN8A

3.69e-04145134HP:0032894
HumanPhenoFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A SCN3A SCN8A

3.69e-04145134HP:0002373
HumanPhenoEpilepsia partialis continua

SCN1A SCN2A

3.91e-0412132HP:0012847
HumanPhenoImpulsivity

SCN1A SCN2A SCN3A SCN8A

4.09e-04149134HP:0100710
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN1A SCN2A

4.62e-0413132HP:0007058
HumanPhenoGeneralized tonic seizure

SCN1A SCN2A SCN8A

4.95e-0464133HP:0010818
HumanPhenoMultifocal epileptiform discharges

SCN1A SCN2A SCN8A

5.42e-0466133HP:0010841
HumanPhenoAthetosis

TRPM3 SCN1A SCN2A SCN8A

6.18e-04166134HP:0002305
HumanPhenoAortopulmonary collateral arteries

SCN1A SCN2A

6.20e-0415132HP:0031834
HumanPhenoPhotosensitive tonic-clonic seizure

SCN1A SCN2A

6.20e-0415132HP:0007207
HumanPhenoFacial tics

SCN1A SCN2A

6.20e-0415132HP:0011468
HumanPhenoDysgenesis of the hippocampus

SCN1A SCN2A

7.07e-0416132HP:0025101
HumanPhenoGeneralized non-motor (absence) seizure

TRPM3 SCN1A SCN2A SCN8A

7.71e-04176134HP:0002121
HumanPhenoInterictal epileptiform activity

GAD1 SCN1A SCN2A SCN3A SCN8A

7.91e-04319135HP:0011182
HumanPhenoAtypical absence status epilepticus

SCN1A SCN2A

8.00e-0417132HP:0011151
HumanPhenoFocal motor status epilepticus

SCN1A SCN2A

8.00e-0417132HP:0032663
HumanPhenoFocal emotional seizure with laughing

SCN1A SCN2A

8.00e-0417132HP:0010821
HumanPhenoVisually-induced seizure

SCN1A SCN2A

8.99e-0418132HP:0020216
HumanPhenoGeneralized non-convulsive status epilepticus without coma

SCN1A SCN2A

8.99e-0418132HP:0032860
HumanPhenoFocal emotional seizure

SCN1A SCN2A

8.99e-0418132HP:0025613
HumanPhenoNon-convulsive status epilepticus without coma

SCN1A SCN2A

1.11e-0320132HP:0032671
HumanPhenoPsychomotor deterioration

SCN2A SCN8A

1.11e-0320132HP:0002361
HumanPhenoNon-motor seizure

TRPM3 SCN1A SCN2A SCN8A

1.18e-03197134HP:0033259
HumanPhenoTalipes valgus

SCN1A SCN2A

1.23e-0321132HP:0004684
HumanPhenoEEG with spike-wave complexes

SCN1A SCN2A SCN8A

1.26e-0388133HP:0010850
HumanPhenoEEG with abnormally slow frequencies

SCN1A SCN3A SCN8A

1.26e-0388133HP:0011203
HumanPhenoEEG abnormality

GAD1 TRPM3 SCN1A SCN2A SCN3A SCN8A

1.33e-03548136HP:0002353
HumanPhenoFocal sensory seizure

SCN1A SCN8A

1.35e-0322132HP:0011157
HumanPhenoReflex seizure

SCN1A SCN2A

1.35e-0322132HP:0020207
HumanPhenoStatus epilepticus

SCN1A SCN2A SCN3A SCN8A

1.42e-03207134HP:0002133
HumanPhenoFocal tonic seizure

SCN2A SCN8A

1.48e-0323132HP:0011167
HumanPhenoTibial torsion

SCN1A SCN2A

1.48e-0323132HP:0100694
HumanPhenoVertical nystagmus

ANO10 SCN1A

1.48e-0323132HP:0010544
HumanPhenoAction tremor

ANO10 SCN1A SCN2A ACBD5

1.50e-03210134HP:0002345
HumanPhenoRigidity

SCN1A SCN2A SCN3A SCN8A

1.61e-03214134HP:0002063
HumanPhenoIntellectual disability, borderline

SCN3A SCN8A

1.75e-0325132HP:0006889
HumanPhenoEpileptic aura

SCN1A SCN8A

1.75e-0325132HP:0033348
HumanPhenoAbnormality of vision

MAK BRIP1 ANO10 TXNL4A ITGB3 SCN1A SCN2A SCN3A SCN8A

1.75e-031373139HP:0000504
HumanPhenoMotor seizure

GAD1 TRPM3 SCN1A SCN2A SCN3A SCN8A

1.90e-03586136HP:0020219
HumanPhenoGeneralized-onset motor seizure

GAD1 SCN1A SCN2A SCN8A

2.03e-03228134HP:0032677
HumanPhenoLimited knee extension

SCN1A SCN2A

2.04e-0327132HP:0003066
HumanPhenoStatus epilepticus without prominent motor symptoms

SCN1A SCN2A

2.04e-0327132HP:0031475
HumanPhenoNystagmus

MAK BRIP1 ANO10 SCN1A SCN2A SCN3A ACBD5 SCN8A

2.11e-031102138HP:0000639
HumanPhenoFocal aware seizure

SCN1A SCN2A

2.19e-0328132HP:0002349
HumanPhenoIntellectual disability, profound

GAD1 SCN1A SCN8A

2.33e-03109133HP:0002187
HumanPhenoStatus epilepticus with prominent motor symptoms

SCN1A SCN2A

2.35e-0329132HP:0032658
HumanPhenoLimb myoclonus

SCN2A SCN8A

2.35e-0329132HP:0045084
HumanPhenoAbnormal involuntary eye movements

MAK BRIP1 ANO10 SCN1A SCN2A SCN3A ACBD5 SCN8A

2.40e-031123138HP:0012547
HumanPhenoChorea

TRPM3 SCN1A SCN2A SCN8A

2.77e-03248134HP:0002072
HumanPhenoCyanosis

SCN1A SCN2A SCN8A

2.85e-03117133HP:0000961
HumanPhenoCogwheel rigidity

SCN1A SCN2A

2.86e-0332132HP:0002396
HumanPhenoEEG with focal epileptiform discharges

SCN1A SCN2A SCN8A

2.92e-03118133HP:0011185
HumanPhenoTremor

ANO10 SCN1A SCN2A SCN3A ACBD5 SCN8A

2.99e-03639136HP:0001337
HumanPhenoObsessive-compulsive trait

SCN1A SCN2A

3.04e-0333132HP:0008770
HumanPhenoCalcaneovalgus deformity

SCN1A SCN2A

3.22e-0334132HP:0001848
HumanPhenoMyoclonic seizure

GAD1 SCN1A SCN2A SCN8A

3.38e-03262134HP:0032794
HumanPhenoDeformed tarsal bones

SCN1A SCN2A

3.41e-0335132HP:0008119
HumanPhenoLimitation of knee mobility

SCN1A SCN2A

3.41e-0335132HP:0010501
HumanPhenoGait ataxia

ANO10 SCN1A SCN2A SCN8A

3.43e-03263134HP:0002066
HumanPhenoLimitation of neck motion

SCN1A SCN2A

3.61e-0336132HP:0005986
HumanPhenoDisturbance of facial expression

SCN1A SCN2A

3.61e-0336132HP:0005324
HumanPhenoAbnormal neck physiology

SCN1A SCN2A

3.61e-0336132HP:0025669
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN8A

4.42e-116264PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN8A

4.42e-116264IPR024583
DomainNa_channel_asu

SCN1A SCN2A SCN3A SCN8A

6.16e-1010264IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN8A

6.16e-1010264IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN8A

6.16e-1010264PF06512
DomainIon_trans_dom

TRPM3 SCN1A SCN2A SCN3A SCN8A

4.61e-07114265IPR005821
DomainIon_trans

TRPM3 SCN1A SCN2A SCN3A SCN8A

4.61e-07114265PF00520
DomainChannel_four-helix_dom

SCN1A SCN2A SCN3A SCN8A

1.11e-0657264IPR027359
Domain-

SCN1A SCN2A SCN3A SCN8A

1.11e-06572641.20.120.350
DomainIQ

SCN1A SCN2A SCN3A SCN8A

4.56e-0681264SM00015
DomainIQ_motif_EF-hand-BS

SCN1A SCN2A SCN3A SCN8A

6.95e-0690264IPR000048
DomainIQ

SCN1A SCN2A SCN3A SCN8A

7.92e-0693264PS50096
DomainIQ

SCN1A SCN3A SCN8A

1.29e-0471263PF00612
DomainEF-hand-dom_pair

SCN1A SCN3A SCN8A

7.19e-03287263IPR011992
Domain-

ACOT1 DAGLA

1.18e-021192623.40.50.1820
DomainAB_hydrolase

ACOT1 DAGLA

1.18e-02119262IPR029058
Domain7tm_1

GPR161 GPR18 HTR7 OR2AJ1

1.36e-02677264PF00001
PathwayWP_DRAVET_SYNDROME

SCN1A SCN2A SCN3A SCN8A

1.29e-0728244M45519
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN3A SCN8A

1.97e-0731244M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN3A SCN8A

2.25e-0732244M27455
PathwayREACTOME_L1CAM_INTERACTIONS

ITGB3 SCN1A SCN2A SCN3A SCN8A

1.60e-06121245M872
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

GAD1 HTR7 DAGLA SCN1A SCN2A SCN3A SCN8A

1.81e-06367247M48346
PathwayREACTOME_CARDIAC_CONDUCTION

SCN1A SCN2A SCN3A SCN8A

6.36e-05130244M27454
PathwayWP_RETT_SYNDROME

SCN1A SCN2A SCN8A

7.13e-0548243M39759
PathwayWP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL

GAD1 SCN1A SCN3A

2.49e-0473243MM16641
PathwayREACTOME_MUSCLE_CONTRACTION

SCN1A SCN2A SCN3A SCN8A

3.54e-04203244M5485
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A SCN8A

2.88e-13427417537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A SCN8A

2.88e-13427435031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A SCN8A

2.88e-13427429578003
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

GAD1 SCN1A SCN2A SCN3A

2.88e-1342748974318
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A SCN8A

4.31e-12627423652591
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A SCN8A

3.62e-11927415746173
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A SCN8A

3.62e-11927416382098
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

GAD1 SCN1A SCN2A SCN3A

1.42e-10122748169823
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A SCN8A

1.42e-101227430175250
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN8A

2.05e-101327415123669
Pubmed

Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.

GAD1 SCN1A SCN2A

4.17e-10327328784306
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

4.17e-10327312610651
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A SCN8A

4.17e-10327317928448
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

4.17e-10327323859570
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

4.17e-10327314973256
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

4.17e-10327318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

4.17e-10327317544618
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A SCN8A

4.17e-10327332845893
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A SCN8A

4.17e-10327328518218
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A SCN8A

1.67e-09427321156207
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

1.67e-09427335801810
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

4.17e-0952731679748
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A

4.17e-0952738812438
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

4.17e-09527324337656
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A SCN8A

4.17e-09527317724025
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A SCN8A

1.46e-08727325818041
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN2A SCN3A

1.89e-07152739726281
Pubmed

Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.

GAD1 SCN1A SCN2A SCN3A

2.70e-07712748751373
Pubmed

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.

GAD1 SCN2A SCN8A

3.38e-071827337321992
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

5.80e-07227229649454
Pubmed

Sodium channel expression within chronic multiple sclerosis plaques.

SCN2A SCN8A

5.80e-07227217805013
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

5.80e-07227220346423
Pubmed

Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.

SCN1A SCN2A

5.80e-07227226311622
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

5.80e-07227237901435
Pubmed

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.

SCN1A SCN8A

5.80e-07227233411788
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

5.80e-07227226410685
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

5.80e-07227231943325
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

5.80e-07227210827969
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

5.80e-07227215249644
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

5.80e-07227227690330
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

5.80e-07227219694741
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

5.80e-07227235348308
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

5.80e-07227211245985
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

5.80e-07227215760941
Pubmed

The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.

SCN1A SCN2A

5.80e-07227221377452
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

5.80e-0722721317301
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

5.80e-07227218601978
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

5.80e-07227223965409
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

5.80e-07227223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

5.80e-07227227153334
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

5.80e-07227233096315
Pubmed

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

SCN2A SCN8A

5.80e-07227219465131
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

5.80e-07227224990319
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

5.80e-07227231439038
Pubmed

Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.

SCN1A SCN8A

5.80e-07227237665666
Pubmed

The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.

SCN1A SCN8A

5.80e-07227217881658
Pubmed

SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.

SCN1A SCN2A

5.80e-07227230693367
Pubmed

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.

SCN2A SCN8A

5.80e-07227223735284
Pubmed

Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.

SCN1A SCN8A

1.74e-06327224704313
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A

1.74e-06327219284629
Pubmed

Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.

SCN1A SCN2A

1.74e-06327219270815
Pubmed

Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.

SCN2A SCN3A

1.74e-06327216052353
Pubmed

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

SCN1A SCN2A

1.74e-06327232185219
Pubmed

Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.

SCN1A SCN2A

1.74e-06327232005694
Pubmed

Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.

SCN1A SCN2A

1.74e-06327225155934
Pubmed

The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.

SCN1A SCN8A

1.74e-06327228117367
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A

1.74e-06327233895391
Pubmed

Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.

SCN2A SCN8A

1.74e-06327238514708
Pubmed

Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.

SCN1A SCN8A

1.74e-06327226182346
Pubmed

Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.

SCN2A SCN8A

1.74e-06327216033895
Pubmed

Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.

SCN2A SCN8A

1.74e-06327229991598
Pubmed

De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.

SCN1A SCN8A

1.74e-06327231054517
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

SCN1A SCN3A

1.74e-06327227816501
Pubmed

Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.

GAD1 SCN1A

3.48e-06427225024183
Pubmed

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

SCN1A SCN2A

3.48e-06427226637798
Pubmed

Models for discovery of targeted therapy in genetic epileptic encephalopathies.

SCN1A SCN8A

3.48e-06427228742937
Pubmed

Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels.

GAD1 SCN1A

3.48e-06427234491914
Pubmed

Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.

SCN2A SCN8A

5.80e-06527224077057
Pubmed

Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism.

HTR7 ITGB3

5.80e-06527217406648
Pubmed

Small CTD phosphatases function in silencing neuronal gene expression.

GAD1 SCN2A

5.80e-06527215681389
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN3A SCN8A

5.80e-06527222875929
Pubmed

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.

GAD1 SCN1A

5.80e-06527223922229
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN3A SCN8A

8.69e-06627223711479
Pubmed

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?

SCN2A SCN8A

8.69e-06627217513486
Pubmed

Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene.

GAD1 SCN3A

8.69e-0662729143501
Pubmed

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.

SCN1A SCN8A

1.22e-05727215272007
Pubmed

Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

GAD1 SCN3A

2.08e-0592728854872
Pubmed

Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory.

GAD1 SCN2A

2.08e-05927231249508
Pubmed

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

SCN1A SCN8A

2.08e-05927217884088
Pubmed

Common variants associated with general and MMR vaccine-related febrile seizures.

SCN1A SCN2A

2.60e-051027225344690
Pubmed

Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area.

GAD1 SLCO1C1

2.60e-051027229377458
Pubmed

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding.

GAD1 DAGLA

2.60e-051027220962221
Pubmed

Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.

SCN1A SCN2A

2.60e-051027220602612
Pubmed

Thyroid Hormone Transporter Deficiency in Mice Impacts Multiple Stages of GABAergic Interneuron Development.

GAD1 SLCO1C1

4.50e-051327234339499
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

SCN2A SCN8A

4.50e-051327216723544
Pubmed

Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunits.

GAD1 SCN3A

5.25e-05142727490102
Pubmed

Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.

GAD1 DAGLA

6.92e-051627218562289
Pubmed

Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome.

GAD1 SLCO1C1

7.84e-051727219641107
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

SCN1A SCN3A SCN8A

1.70e-0413927316985003
Pubmed

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

GAD1 SCN8A

5.63e-044527225979088
InteractionSCN4B interactions

SCN1A SCN2A SCN8A

1.20e-078273int:SCN4B
Cytoband2q24.3

SCN1A SCN2A

3.98e-05162722q24.3
CytobandEnsembl 112 genes in cytogenetic band chr2q24

SCN1A SCN2A SCN3A

5.76e-05127273chr2q24
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A SCN8A

8.64e-1191841203
GeneFamilyG protein-coupled receptors, Class A orphans

GPR161 GPR18

2.69e-0378182262
CoexpressionAtlasBM Top 100 - thalamus

GAD1 SCN1A SCN2A

5.21e-0562253BM Top 100 - thalamus
CoexpressionAtlasBM Top 100 - vestibular nuclei superior

GAD1 SCN1A SCN2A

6.87e-0568253BM Top 100 - vestibular nuclei superior
CoexpressionAtlasBM Top 100 - cerebral cortex

GAD1 SCN1A SCN2A

8.15e-0572253BM Top 100 - cerebral cortex
CoexpressionAtlasBM Top 100 - occipital lobe

GAD1 SCN1A SCN2A

8.49e-0573253BM Top 100 - occipital lobe
CoexpressionAtlasBM Top 100 - parietal lobe

GAD1 SCN1A SCN2A

9.20e-0575253BM Top 100 - parietal lobe
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ACOT1 TRPM3 SCN3A ACBD5

1.81e-06147274b66ccc710b3c04f6fc7fed69f3c892fc110e98fc
ToppCellHippocampus-Neuronal-Inhibitory|Hippocampus / BrainAtlas - Mouse McCarroll V32

GAD1 TM6SF1 HTR7 SCN1A

4.23e-06182274b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAD1 ACOT1 ITGB3 SCN8A

4.41e-06184274e33bb572af9dfd11127105f1ac99bc958a7cafbb
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAD1 SCN1A SCN2A SCN8A

4.91e-06189274f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPR161 TRPM3 SCN1A SCN2A

5.55e-06195274787e95fb59c40bba784544b662fac37606ae1427
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN3A SCN8A

5.90e-06198274c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN3A SCN8A

5.90e-061982746d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN3A SCN8A

5.90e-061982744ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 SCN1A SCN2A SCN3A

6.14e-062002744fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 SCN1A SCN2A SCN3A

6.14e-06200274f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 SCN1A SCN2A SCN3A

6.14e-06200274cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 SCN1A SCN2A SCN3A

6.14e-06200274310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 SCN1A SCN2A SCN3A

6.14e-06200274c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 SCN1A SCN2A SCN3A

6.14e-06200274961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GAD1 TM6SF1 HTR7

4.79e-051172730602bbad908cb28c5093b74d717da5f2af577943
ToppCell|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HACD4 HTR7 ENPP3

5.29e-05121273da8fe561dcf50792d0cbcaad383d564f900a6677
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

BRIP1 GPR18 HTR7

8.88e-0514427338ff324366ad5be626e3657c1e33277fc36ddd4c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

9.44e-051472732885978bcfc5623967c0c1204dadf5c78c74a082
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACOT1 BRIP1 SCN2A

9.63e-0514827318cfecd6ae20edb74f5d44ba759909df356acf3a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.04e-04152273eee86b508b8f140ea44e21d8c04c409a7b689e39
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SCN1A SCN2A SCN3A

1.10e-0415527377fdae85d36efb776db977eb424b32487ef222e4
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRPM3 DAGLA ENPP3

1.10e-0415527396c48d835725eac1bc7926f4cddecb67c29b7d7c
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM6SF1 HTR7 SCN1A

1.17e-04158273bd37d567754b660bfff7aef81cb307a384ec20a0
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Hippocampus / BrainAtlas - Mouse McCarroll V32

GAD1 TM6SF1 SCN1A

1.24e-04161273b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.24e-04161273133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.24e-04161273cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.24e-041612739466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.26e-04162273285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.26e-0416227396c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.30e-041642736fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.33e-04165273347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.33e-041652731890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.33e-04165273507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.33e-0416527339a25be081a5d59c7cf107a997d352793d5025fb
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OSER1 BRIP1 ABCB9

1.33e-04165273ba68090d79e2243af2bdee0c27a32e65f540f8ac
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TM6SF1 TMEM269 SCN8A

1.40e-0416827384977db9d71e59208727885320cc18d80d064380
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 HTR7 TRPM3

1.40e-041682732eed7dc1a2aff11be024823c4323c42bc94362f6
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.43e-04169273f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.43e-041692730332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

GAD1 TM6SF1 HTR7

1.43e-04169273c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.45e-0417027335e3945d8a540a3e2cec1b559316265aaad023d1
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 HTR7 ENPP3

1.45e-0417027340675b55269ffa57fb7fcdb903c81b02b4e01f8f
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR18 ANO10 ITGB3

1.45e-041702733ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.45e-041702730ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP3 SCN1A SCN3A

1.45e-041702730b5ddc7d452db0a389927a367914f7d257703f7e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 HARBI1 SCN8A

1.53e-04173273506efcaa5afd6ed5e565c4c4def6a4505fea97c5
ToppCell10x5'-GI_small-bowel-Mast|GI_small-bowel / Manually curated celltypes from each tissue

GPR161 TM6SF1 ENPP3

1.55e-04174273e94c980b25edfd0e8598c416828801fcc00e8ead
ToppCell10x5'-GI_small-bowel-Mast-Mast_cells|GI_small-bowel / Manually curated celltypes from each tissue

GPR161 TM6SF1 ENPP3

1.55e-0417427305525bf0a2bde2be4f7c147b17a24530ce8819e0
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 HTR7 TRPM3

1.63e-041772732b675840b7d2bb536c2c600936733bd9e97e7120
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 HTR7 TRPM3

1.63e-041772735e0fca9bd5e5ffe6d39f5bcd81f36512f3b0cb1b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAD1 SCN2A SCN3A

1.63e-04177273dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.63e-04177273f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCelldroplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACOT1 MAK BRIP1

1.66e-04178273de6cd81e6d58e7687386df163471bf1901b9c0aa
ToppCellPND10-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAD1 HACD4 ITGB3

1.66e-04178273aa659bd283c4dfbe292cd8698bbf6b1999ca3314
ToppCellPND10-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAD1 HACD4 ITGB3

1.66e-041782739e1f2596fcea5b79cc50b58d83706bb8605e224f
ToppCellPND10-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAD1 HACD4 ITGB3

1.66e-04178273bf1d273802a4f42e52ea1bd2a0cae2039559c093
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SCN1A SCN2A SCN3A

1.69e-04179273af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 SCN2A SCN3A

1.72e-04180273401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.72e-04180273788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCelldroplet-Lung-nan-18m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAD1 MAK TRPM3

1.72e-0418027343fd5c498a87bb078d101298b472656f3294686a
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

SCN2A SCN3A SCN8A

1.77e-0418227357bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAD1 SCN2A SCN3A

1.77e-041822735f513bbb7125956eb528e3120de3fd776770a7c3
ToppCellGlobus_pallidus-Neuronal-Inhibitory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

GAD1 HTR7 SCN1A

1.77e-0418227304ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.80e-04183273b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.80e-04183273d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCelldroplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GAD1 MAK TRPM3

1.80e-04183273e91f00b75d43ee6293fdd4a129b789cd95f8d11a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

1.83e-041842737d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.89e-0418627308632045d499e61dd96ff29a5a9a208afe58dc58
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

1.89e-041862737278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPR161 GAD1 HTR7

1.89e-0418627377592a6397b44b2b59a4fc39d7224dd95343efe6
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SCN2A SCN3A SCN8A

1.89e-04186273b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.92e-04187273f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.92e-041872732d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

1.92e-041872737b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.92e-04187273e3095455d2f255854f339f6b05fa87852af0700f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GAD1 SCN2A SCN3A

1.95e-04188273eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

GAD1 SCN2A SCN3A

1.95e-041882731d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GPR161 SCN2A SCN3A

1.95e-04188273b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SCN2A SCN3A SCN8A

1.95e-04188273c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAD1 SCN1A SCN8A

1.95e-041882731efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GAD1 SCN2A SCN3A

1.95e-04188273bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.98e-041892733a295c215b5c18e7c673f92b7af5be523421682c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

1.98e-04189273532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GPR18 SCN2A SCN3A

2.01e-04190273a7498fe55b7810c482291db782dc5282675d246a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPR161 GAD1 HTR7

2.01e-041902732f54da2bee411f8868348a4c37034184b8f58a89
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 TM6SF1 HTR7

2.01e-0419027339ab890104b4264c68a968f920f4ccd84f0bc681
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 TM6SF1 HTR7

2.01e-041902730acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

GAD1 HTR7 SCN2A

2.04e-041912735d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

GAD1 HTR7 SCN2A

2.04e-0419127373dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

2.04e-0419127396b78b4e819ea6052334bfcbc7abbf35897df885
ToppCellCOVID-19-kidney-CNT|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRPM3 SCN2A SCN3A

2.08e-04192273760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

2.08e-041922730bb06738e1c3ec0c044a7ee61f6cf1d4781fb53c
ToppCellEntopeduncular-Neuronal|Entopeduncular / BrainAtlas - Mouse McCarroll V32

HTR7 SCN2A SCN8A

2.08e-041922734c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

2.11e-04193273be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

2.11e-041932730c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

2.11e-041932738689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

2.11e-041932735fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

2.14e-04194273be869e186386d03ebb670971dd24fa656b4b0edf
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 SCN2A SCN3A

2.14e-041942734d6c9b016e3a0641954a8ea10c97d1cd76fadd9f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN2A SCN3A SCN8A

2.20e-04196273676c56b44ac29f7baecb62f49bb8597cc74c0a88
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A SCN8A

2.97e-086273ctd:C475726
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN3A SCN8A

8.30e-088273ctd:C489827
DrugZonisamide

SCN1A SCN2A SCN3A

1.00e-0617273DB00909
DrugProxyphylline [603-00-9]; Up 200; 16.8uM; PC3; HT_HG-U133A

GAD1 ABCB9 HTR7 DAGLA SCN3A

3.35e-061992757290_UP
DrugAPETx2 protein, Anthopleura elegantissima

SCN2A SCN8A

8.11e-064272ctd:C501880
DrugTetrodotoxin

SCN2A SCN3A SCN8A

1.43e-0540273ctd:D013779
Drugfenpropathrin

SCN2A SCN3A

2.03e-056272ctd:C044267
Drugdecamethrin

SCN1A SCN2A SCN3A SCN8A

2.54e-05146274ctd:C017180
Drugminaprine

BRIP1 HTR7 ENPP3

3.54e-0554273CID000004199
DrugLY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A

GPR161 MAK ITGB3 SCN8A

7.85e-051952745576_UP
Drug(1)-Nipecotic acid [498-95-3]; Up 200; 31uM; MCF7; HT_HG-U133A

TRPM3 ITGB3 DAGLA SCN8A

8.00e-051962745999_UP
DrugCitalopram hydrobromide [59729-32-7]; Up 200; 1uM; PC3; HT_HG-U133A

GPR161 GAD1 ABCB9 SCN8A

8.16e-051972744555_UP
DrugPempidine tartrate [546-48-5]; Up 200; 13uM; MCF7; HT_HG-U133A

ABCB9 TM6SF1 ITGB3 SCN8A

8.16e-051972743832_UP
DrugNitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; MCF7; HT_HG-U133A

GPR161 GAD1 ABCB9 TRPM3

8.16e-051972746043_UP
DrugTHIP Hydrochloride; Up 200; 22.6uM; MCF7; HT_HG-U133A

GAD1 ABCB9 TRPM3 ITGB3

8.49e-051992746511_UP
DrugKetanserin tartrate hydrate [83846-83-7]; Up 200; 7uM; MCF7; HT_HG-U133A

MAK ABCB9 HTR7 DAGLA

8.49e-051992744995_UP
DrugEsculin Hydrate [531-75-9]; Up 200; 11.8uM; HL60; HT_HG-U133A

GAD1 SLCO1C1 HTR7 SCN2A

8.49e-051992743052_UP
DrugPargyline hydrochloride [306-07-0]; Up 200; 20.4uM; MCF7; HT_HG-U133A

GAD1 MAK ABCB9 ITGB3

8.65e-052002742265_UP
Drugtrimethylammonium bromide

ENPP3 SCN2A

8.87e-0512272CID000071370
DrugN-(p-amylcinnamoyl)anthranilic acid

TRPM3 DAGLA

1.22e-0414272CID000001974
Drugtetradotoxin

GAD1 HTR7 SCN2A SCN3A SCN8A

1.32e-04428275CID000020382
DrugSodium

SCN2A SCN3A SCN8A

1.33e-0484273ctd:D012964
Drug6-oxohexanoate

GAD1 MPG

1.41e-0415272CID000440918
DrugPD 150606

SCN2A SCN3A

1.82e-0417272ctd:C100442
DrugPGW5 compound

GAD1 HTR7

1.82e-0417272ctd:C000593032
DrugScorpion Venoms

SCN2A SCN3A

2.05e-0418272ctd:D012604
Drugsuccinamide

ENPP3 SCN2A

2.05e-0418272CID000008036
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN8A

9.91e-1110264DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN8A

9.91e-1110264DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN8A

2.33e-1012264DOID:0060170 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

HTR7 SCN1A SCN2A SCN3A

3.43e-0922264DOID:2030 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

GAD1 SCN1A SCN2A SCN3A SCN8A

2.90e-07163265DOID:1826 (implicated_via_orthology)
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

2.24e-063262cv:C5575231
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

1.12e-056262C0220669
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

1.56e-057262C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

1.56e-057262C0751057
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A

2.68e-059262C3502809
DiseaseFebrile Convulsions

SCN1A SCN2A

2.68e-059262C0009952
DiseaseEpilepsy, Cryptogenic

SCN1A SCN2A SCN8A

5.14e-0582263C0086237
DiseaseAwakening Epilepsy

SCN1A SCN2A SCN8A

5.14e-0582263C0751111
DiseaseAura

SCN1A SCN2A SCN8A

5.14e-0582263C0236018
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A

5.79e-0513262C0751122
DiseaseNeurodevelopmental Disorders

SCN1A SCN2A SCN8A

7.48e-0593263C1535926
DiseaseMMR-related febrile seizures

SCN1A SCN2A

7.78e-0515262EFO_0006519
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

8.89e-0516262C0393706
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

1.13e-0418262HP_0002373
DiseaseEpilepsy

SCN1A SCN2A SCN8A

1.20e-04109263C0014544
Diseasesoluble triggering receptor expressed on myeloid cells 2 measurement

MAK ANO10 DAGLA SCN1A

1.25e-04296264EFO_0010151
Diseasethrombocytopenia (is_implicated_in)

BRIP1 ITGB3

2.59e-0427262DOID:1588 (is_implicated_in)
DiseaseIntellectual Disability

TRPM3 SCN1A SCN3A SCN8A

5.96e-04447264C3714756

Protein segments in the cluster

PeptideGeneStartEntry
MALAYYNYEDLPKTM

ACOT1

186

Q86TX2
FQPTNEMMLKFYSFY

ACBD5

61

Q5T8D3
FIMTLPFRMFYYAKD

GPR18

71

Q14330
LYFSLYVMMIYFDME

ANO10

326

Q9NW15
YFPYVLKIYLMMLFI

HACD4

191

Q5VWC8
NMYSIMAARYKYFPE

GAD1

256

Q99259
MSMYGFPRQFIYYLV

HARBI1

36

Q96MB7
YFPYKAYPSQLAMMN

BRIP1

16

Q9BX63
YMRAMYPTKTFPNHY

ENPP3

196

O14638
LYVYIIYGMYFCMNI

MPG

156

P29372
YFIFEYMKENLYQLM

MAK

76

P20794
MLRYKEVCYYMLFAL

DAGLA

286

Q9Y4D2
YPVDIYYLMDLSYSM

ITGB3

136

P05106
YYAVLYPMVYPMKIT

GPR161

126

Q8N6U8
IVVTMYYGPFIFTYM

OR2AJ1

246

Q8NGZ0
EMVLKIIAMDPYYYF

SCN3A

806

Q9NY46
GYMEYYLYIPKKMSH

OSER1

271

Q9NX31
FLKIIAMDPYYYFQE

SCN1A

816

P35498
FPIIMMVSNIYGKYY

ABCB9

336

Q9NP78
VAFYIPMSVMLFMYY

HTR7

246

P34969
ILFMMDQSYYPYDKI

TMEM269

176

A0A1B0GVZ9
AKNIFYMPYWMIYGE

TRPM3

1066

Q9HCF6
IAMPQFFMEQYKYER

SLCO1C1

126

Q9NYB5
MFLKIIAMDPYYYFQ

SCN2A

806

Q99250
FLKLIAMDPYYYFQE

SCN8A

801

Q9UQD0
KMYELYDPCTVMFFF

TXNL4A

71

P83876
MQLTFRKMAFDYYPF

UHRF1BP1

356

Q6BDS2
AAYPKIQMLAYMFYS

TM6SF1

261

Q9BZW5
IQMLAYMFYSVPYFV

TM6SF1

266

Q9BZW5