Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin binding

DIAPH1 DIAPH2 FMN2 DAAM2 WASL DAAM1 WAS INF2 FMN1 SHANK3 FMNL1 VASP WASF2 WASF3 KLHL17

2.20e-144794215GO:0003779
GeneOntologyMolecularFunctioncytoskeletal protein binding

DIAPH1 DIAPH2 FMN2 DAAM2 WASL DAAM1 WAS INF2 FMN1 SHANK3 FMNL1 VASP WASF2 WASF3 KLHL17

2.84e-0910994215GO:0008092
GeneOntologyMolecularFunctionSH3 domain binding

WAS FMN1 SHANK3 DTX1 VASP WASF2

5.15e-07143426GO:0017124
GeneOntologyMolecularFunctionprofilin binding

DIAPH1 FMNL1 VASP

2.44e-0613423GO:0005522
GeneOntologyMolecularFunctionsmall GTPase binding

DIAPH1 DIAPH2 DAAM2 DAAM1 WAS INF2 FMNL1

4.33e-06321427GO:0031267
GeneOntologyMolecularFunctionGTPase binding

DIAPH1 DIAPH2 DAAM2 DAAM1 WAS INF2 FMNL1

9.15e-06360427GO:0051020
GeneOntologyMolecularFunctionprotein domain specific binding

WT1 WBP11 WAS HCN2 FMN1 SHANK3 DTX1 VASP WASF2 KLHL17

1.02e-058754210GO:0019904
GeneOntologyMolecularFunctionArp2/3 complex binding

WASF2 WASF3

5.09e-0416422GO:0071933
GeneOntologyMolecularFunctionprotein kinase A regulatory subunit binding

WASF2 WASF3

1.26e-0325422GO:0034237
GeneOntologyBiologicalProcessactin cytoskeleton organization

DIAPH1 DIAPH2 FMN2 DAAM2 WASL DAAM1 WAS INF2 FMN1 SHANK3 FMNL1 VASP WASF2 WASF3 KLHL17

1.55e-118034115GO:0030036
GeneOntologyBiologicalProcessactin nucleation

DIAPH1 FMN2 WASL INF2 FMN1 WASF2 WASF3

4.57e-1165417GO:0045010
GeneOntologyBiologicalProcessactin filament-based process

DIAPH1 DIAPH2 FMN2 DAAM2 WASL DAAM1 WAS INF2 FMN1 SHANK3 FMNL1 VASP WASF2 WASF3 KLHL17

9.30e-119124115GO:0030029
GeneOntologyBiologicalProcessactin filament polymerization

DIAPH1 DIAPH2 DAAM2 WASL WAS INF2 FMN1 VASP WASF3

1.07e-10190419GO:0030041
GeneOntologyBiologicalProcessactin filament organization

DIAPH1 DIAPH2 FMN2 DAAM2 WASL WAS INF2 FMN1 SHANK3 VASP WASF2 WASF3

1.85e-105094112GO:0007015
GeneOntologyBiologicalProcessactin polymerization or depolymerization

DIAPH1 DIAPH2 DAAM2 WASL WAS INF2 FMN1 VASP WASF3

4.28e-10222419GO:0008154
GeneOntologyBiologicalProcessprotein polymerization

DIAPH1 DIAPH2 DAAM2 WASL WAS INF2 FMN1 VASP WASF3

1.53e-08334419GO:0051258
GeneOntologyBiologicalProcesssupramolecular fiber organization

DIAPH1 DIAPH2 FMN2 DAAM2 WASL WAS INF2 FMN1 SHANK3 VASP WASF2 WASF3

2.11e-079574112GO:0097435
GeneOntologyBiologicalProcessregulation of actin filament organization

DAAM2 WAS FMN1 SHANK3 VASP WASF2 WASF3

1.89e-06300417GO:0110053
GeneOntologyBiologicalProcesspositive regulation of actin nucleation

FMN1 WASF2 WASF3

2.61e-0614413GO:0051127
GeneOntologyBiologicalProcessregulation of actin cytoskeleton organization

DAAM2 WAS FMN1 SHANK3 VASP WASF2 WASF3

9.56e-06384417GO:0032956
GeneOntologyBiologicalProcessregulation of cytoskeleton organization

DIAPH1 DAAM2 WAS FMN1 SHANK3 VASP WASF2 WASF3

1.55e-05579418GO:0051493
GeneOntologyBiologicalProcessregulation of actin filament-based process

DAAM2 WAS FMN1 SHANK3 VASP WASF2 WASF3

2.24e-05438417GO:0032970
GeneOntologyBiologicalProcessregulation of supramolecular fiber organization

DAAM2 WAS FMN1 SHANK3 VASP WASF2 WASF3

2.24e-05438417GO:1902903
GeneOntologyBiologicalProcessneuron projection retraction

DIAPH1 DIAPH2

2.31e-054412GO:0106028
GeneOntologyBiologicalProcessmulticellular organismal locomotion

DIAPH1 DIAPH2

2.31e-054412GO:0071965
GeneOntologyBiologicalProcesspositive regulation of clathrin-dependent endocytosis

DGKD WASL

3.84e-055412GO:2000370
GeneOntologyBiologicalProcessregulation of actin nucleation

FMN1 WASF2 WASF3

7.37e-0541413GO:0051125
GeneOntologyBiologicalProcessaxon midline choice point recognition

DIAPH1 DIAPH2

8.04e-057412GO:0016199
GeneOntologyBiologicalProcessnegative regulation of actin filament bundle assembly

WAS SHANK3 WASF2

9.76e-0545413GO:0032232
GeneOntologyBiologicalProcesspositive regulation of Arp2/3 complex-mediated actin nucleation

WASF2 WASF3

1.07e-048412GO:2000601
GeneOntologyBiologicalProcessneuron projection organization

DIAPH1 DIAPH2 WASL SHANK3

1.16e-04127414GO:0106027
GeneOntologyBiologicalProcessaxon choice point recognition

DIAPH1 DIAPH2

1.38e-049412GO:0016198
GeneOntologyBiologicalProcessregulation of cellular component size

DAAM2 WAS INF2 FMN1 SHANK3 VASP

1.83e-04426416GO:0032535
GeneOntologyBiologicalProcessregulation of actin polymerization or depolymerization

DAAM2 WAS FMN1 VASP

4.14e-04177414GO:0008064
GeneOntologyBiologicalProcessregulation of actin filament length

DAAM2 WAS FMN1 VASP

4.41e-04180414GO:0030832
GeneOntologyBiologicalProcesslamellipodium assembly

WAS WASF2 WASF3

5.19e-0479413GO:0030032
GeneOntologyBiologicalProcessactin filament bundle assembly

FMN2 WAS SHANK3 WASF2

5.52e-04191414GO:0051017
GeneOntologyBiologicalProcessactin filament bundle organization

FMN2 WAS SHANK3 WASF2

5.97e-04195414GO:0061572
GeneOntologyBiologicalProcesspositive regulation of supramolecular fiber organization

FMN1 VASP WASF2 WASF3

6.08e-04196414GO:1902905
GeneOntologyBiologicalProcesspositive regulation of cytoskeleton organization

FMN1 VASP WASF2 WASF3

7.20e-04205414GO:0051495
GeneOntologyBiologicalProcessregulation of clathrin-dependent endocytosis

DGKD WASL

7.90e-0421412GO:2000369
GeneOntologyBiologicalProcessnegative regulation of neuron projection regeneration

DIAPH1 DIAPH2

8.68e-0422412GO:0070571
GeneOntologyBiologicalProcessmetanephric nephron morphogenesis

WT1 FMN1

9.50e-0423412GO:0072273
GeneOntologyBiologicalProcesslamellipodium organization

WAS WASF2 WASF3

1.00e-0399413GO:0097581
GeneOntologyBiologicalProcessregulation of organelle organization

DIAPH1 DAAM2 WAS INF2 FMN1 SHANK3 VASP WASF2 WASF3

1.07e-031342419GO:0033043
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

DIAPH1 DIAPH2 DAAM2 WASL WAS SHANK3 WASF2

1.27e-03846417GO:0120035
GeneOntologyBiologicalProcessregulation of anatomical structure size

DAAM2 WAS INF2 FMN1 SHANK3 VASP

1.30e-03618416GO:0090066
GeneOntologyBiologicalProcessepithelial tube morphogenesis

WT1 ZIC5 FMN1 SHANK3 VASP

1.42e-03421415GO:0060562
GeneOntologyBiologicalProcessregulation of cell projection organization

DIAPH1 DIAPH2 DAAM2 WASL WAS SHANK3 WASF2

1.42e-03863417GO:0031344
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection assembly

DAAM2 WASL WAS WASF2

1.46e-03248414GO:0120032
GeneOntologyBiologicalProcessmetanephros morphogenesis

WT1 FMN1

1.51e-0329412GO:0003338
GeneOntologyBiologicalProcessregulation of cell projection assembly

DAAM2 WASL WAS WASF2

1.52e-03251414GO:0060491
GeneOntologyBiologicalProcessgliogenesis

DAAM2 MMP24 SHANK3 DTX1 WASF3

1.64e-03435415GO:0042063
GeneOntologyBiologicalProcesspostsynaptic actin cytoskeleton organization

WASL WASF2

1.73e-0331412GO:0098974
GeneOntologyBiologicalProcesssex determination

WT1 SF1

1.73e-0331412GO:0007530
GeneOntologyBiologicalProcessregulation of Arp2/3 complex-mediated actin nucleation

WASF2 WASF3

1.73e-0331412GO:0034315
GeneOntologyBiologicalProcessregulation of actin filament bundle assembly

WAS SHANK3 WASF2

1.87e-03123413GO:0032231
GeneOntologyBiologicalProcesscell morphogenesis

DIAPH1 DIAPH2 WASL SHANK3 FMNL1 VASP WASF2 WASF3

2.13e-031194418GO:0000902
GeneOntologyBiologicalProcesspostsynaptic cytoskeleton organization

WASL WASF2

2.20e-0335412GO:0099188
GeneOntologyCellularComponentactin cytoskeleton

DIAPH1 DIAPH2 FMN2 WASL DAAM1 WAS INF2 FMN1 VASP WASF2 KLHL17

1.25e-085764211GO:0015629
GeneOntologyCellularComponentactin filament

DIAPH1 DIAPH2 FMN2 WAS INF2 FMN1

4.46e-07146426GO:0005884
GeneOntologyCellularComponentSCAR complex

WASF2 WASF3

2.57e-0412422GO:0031209
GeneOntologyCellularComponentcell leading edge

DIAPH1 WASL HCN2 VASP WASF2 WASF3

4.59e-04500426GO:0031252
GeneOntologyCellularComponentcollagen trimer

COL8A1 GLDN EMID1

7.35e-0488423GO:0005581
GeneOntologyCellularComponentlamellipodium

WASL VASP WASF2 WASF3

1.15e-03230424GO:0030027
GeneOntologyCellularComponentnuclear body

WT1 WBP11 RBM27 CPSF6 SF1 DTX1 ZBTB4

1.97e-03903427GO:0016604
DomainFH2

DIAPH1 DIAPH2 FMN2 DAAM2 DAAM1 INF2 FMN1 FMNL1

2.05e-1815428PS51444
DomainFH2_Formin

DIAPH1 DIAPH2 FMN2 DAAM2 DAAM1 INF2 FMN1 FMNL1

2.05e-1815428IPR015425
DomainFH2

DIAPH1 DIAPH2 FMN2 DAAM2 DAAM1 INF2 FMN1 FMNL1

2.05e-1815428PF02181
DomainFH2

DIAPH1 DIAPH2 FMN2 DAAM2 DAAM1 INF2 FMN1 FMNL1

2.05e-1815428SM00498
DomainDrf_GBD

DIAPH1 DIAPH2 DAAM2 DAAM1 INF2 FMNL1

7.44e-159426PF06371
DomainFH3_dom

DIAPH1 DIAPH2 DAAM2 DAAM1 INF2 FMNL1

7.44e-159426IPR010472
DomainGTPase-bd

DIAPH1 DIAPH2 DAAM2 DAAM1 INF2 FMNL1

7.44e-159426IPR010473
DomainDrf_FH3

DIAPH1 DIAPH2 DAAM2 DAAM1 INF2 FMNL1

7.44e-159426PF06367
DomainDrf_FH3

DIAPH1 DIAPH2 DAAM2 DAAM1 INF2 FMNL1

7.44e-159426SM01139
DomainDrf_GBD

DIAPH1 DIAPH2 DAAM2 DAAM1 INF2 FMNL1

7.44e-159426SM01140
DomainGBD/FH3_dom

DIAPH1 DIAPH2 DAAM2 DAAM1 INF2 FMNL1

4.08e-1411426IPR014768
DomainGBD_FH3

DIAPH1 DIAPH2 DAAM2 DAAM1 INF2 FMNL1

4.08e-1411426PS51232
DomainDAD_dom

DIAPH1 DIAPH2 DAAM2 DAAM1 FMNL1

2.50e-128425IPR014767
DomainDAD

DIAPH1 DIAPH2 DAAM2 DAAM1 FMNL1

2.50e-128425PS51231
DomainWH2

WASL WAS INF2 WASF2 WASF3

8.86e-1114425SM00246
DomainWH2

WASL WAS INF2 WASF2 WASF3

1.93e-1016425PF02205
DomainWH2_dom

WASL WAS INF2 WASF2 WASF3

8.91e-1021425IPR003124
DomainWH2

WASL WAS INF2 WASF2 WASF3

1.85e-0924425PS51082
DomainWH1

WASL WAS VASP

1.72e-0611423SM00461
DomainWH1/EVH1_dom

WASL WAS VASP

1.72e-0611423IPR000697
DomainWH1

WASL WAS VASP

1.72e-0611423PF00568
DomainWH1

WASL WAS VASP

2.98e-0613423PS50229
DomainWASPfam_EVH1

WASL WAS

4.94e-062422IPR033927
DomainDrf_FH1

DIAPH1 FMN2

4.94e-062422PF06346
DomainFormin_homology_1

DIAPH1 FMN2

4.94e-062422IPR009408
DomainDrf_DAD

DIAPH1 DIAPH2

1.48e-053422IPR010465
DomainDrf_DAD

DIAPH1 DIAPH2

1.48e-053422PF06345
DomainSCAR/WAVE_fam

WASF2 WASF3

1.48e-053422IPR028288
DomainWASP_C

WASL WAS

1.03e-047422IPR011026
DomainARM-type_fold

DIAPH1 DIAPH2 DAAM2 DAAM1 INF2 FMNL1

1.03e-04339426IPR016024
Domainzf-CCCH

RBM22 RBM27 ZC3H4

1.81e-0449423PF00642
DomainZnf_CCCH

RBM22 RBM27 ZC3H4

2.99e-0458423IPR000571
DomainZF_C3H1

RBM22 RBM27 ZC3H4

2.99e-0458423PS50103
Domain-

WASL WAS

3.21e-04124223.90.810.10
DomainPBD

WASL WAS

5.81e-0416422SM00285
DomainPBD

WASL WAS

6.57e-0417422PF00786
DomainCRIB

WASL WAS

9.14e-0420422PS50108
DomainCollagen

COL8A1 GLDN EMID1

9.19e-0485423PF01391
DomainCollagen

COL8A1 GLDN EMID1

9.19e-0485423IPR008160
DomainCRIB_dom

WASL WAS

1.01e-0321422IPR000095
Domainzf-CCHC

ZCCHC2 SF1

1.21e-0323422PF00098
Domain-

ZCCHC2 SF1

1.55e-03264224.10.60.10
DomainZF_CCHC

ZCCHC2 SF1

2.80e-0335422PS50158
DomainKH_1

SF1 MEX3C

3.30e-0338422PF00013
Domain-

SF1 MEX3C

3.47e-03394223.30.1370.10
DomainKH

SF1 MEX3C

3.65e-0340422SM00322
Domain-

RBM27 ZC3H4

3.65e-03404224.10.1000.10
DomainKH_dom

SF1 MEX3C

3.65e-0340422IPR004087
DomainKH_TYPE_1

SF1 MEX3C

4.02e-0342422PS50084
DomainKH_dom_type_1

SF1 MEX3C

4.40e-0344422IPR004088
DomainZnF_C3H1

RBM22 ZC3H4

5.22e-0348422SM00356
DomainZnF_C2HC

ZCCHC2 SF1

6.80e-0355422SM00343
DomainZnf_CCHC

ZCCHC2 SF1

6.80e-0355422IPR001878
Domain-

DGKD WASL WAS VASP

1.13e-023914242.30.29.30
DomainRRM_1

RBM22 RBM27 CPSF6

1.14e-02208423PF00076
DomainRRM

RBM22 RBM27 CPSF6

1.27e-02217423SM00360
DomainRRM_dom

RBM22 RBM27 CPSF6

1.44e-02227423IPR000504
DomainRRM

RBM22 RBM27 CPSF6

1.49e-02230423PS50102
DomainPH_dom-like

DGKD WASL WAS VASP

1.51e-02426424IPR011993
PathwayREACTOME_RHO_GTPASE_EFFECTORS

DIAPH1 DIAPH2 WASL DAAM1 WAS FMNL1 WASF2 WASF3

4.54e-07323328M27080
PathwayREACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES

WASL WAS WASF2 WASF3

1.22e-0636324M27549
PathwayBIOCARTA_ACTINY_PATHWAY

WASL WASF2 WASF3

1.26e-0610323MM1528
PathwayKEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

WASL WAS VASP WASF2 WASF3

2.30e-0696325M16121
PathwayBIOCARTA_ACTINY_PATHWAY

WASL WASF2 WASF3

2.31e-0612323M7825
PathwayREACTOME_RHO_GTPASE_CYCLE

DIAPH1 DIAPH2 WASL DAAM1 WAS FMNL1 WASF2 WASF3

5.43e-06450328M27078
PathwayREACTOME_RHO_GTPASE_EFFECTORS

DIAPH1 DIAPH2 DAAM1 FMNL1 WASF2 WASF3

2.11e-05257326MM14755
PathwayKEGG_ADHERENS_JUNCTION

WASL WAS WASF2 WASF3

2.13e-0573324M638
PathwayREACTOME_RAC1_GTPASE_CYCLE

WASL WAS FMNL1 WASF2 WASF3

5.43e-05184325M41809
PathwayWP_G13_SIGNALING

DIAPH1 WASL WAS

8.49e-0538323M39606
PathwayWP_G13_SIGNALING_PATHWAY

DIAPH1 WASL WAS

9.19e-0539323MM15898
PathwayKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

DIAPH1 DIAPH2 WASL WAS WASF2

1.09e-04213325M18306
PathwayREACTOME_PARASITE_INFECTION

WASL WAS WASF2 WASF3

1.31e-04116324M29843
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

DIAPH1 DIAPH2 WASL DAAM1 WAS FMNL1 WASF2 WASF3

1.57e-04720328M41838
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

DIAPH1 DIAPH2 DAAM1 FMNL1

2.70e-04140324M27550
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

DIAPH1 DIAPH2 DAAM1 FMNL1

2.77e-04141324MM15266
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

WASL WAS WASF2 WASF3

2.93e-04143324M27107
PathwayREACTOME_CDC42_GTPASE_CYCLE

WASL DAAM1 WAS FMNL1

3.98e-04155324M41808
PathwayREACTOME_RHO_GTPASE_CYCLE

DIAPH1 DIAPH2 DAAM1 FMNL1 WASF2 WASF3

4.01e-04439326MM15595
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_TO_RAC_SIGNALING_PATHWAY

WASF2 WASF3

9.25e-0420322M47737
PathwayPID_ECADHERIN_KERATINOCYTE_PATHWAY

FMN1 VASP

1.02e-0321322M184
PathwayREACTOME_LEISHMANIA_INFECTION

WASL WAS WASF2 WASF3

1.45e-03219324M29836
PathwayKEGG_MEDICUS_REFERENCE_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

WASF2 WASF3

1.45e-0325322M47716
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

WASF2 WASF3

1.95e-0329322M47717
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

WASF2 WASF3

2.09e-0330322M47738
PathwayREACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES

WASF2 WASF3

2.68e-0334322MM15265
PathwaySIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES

WASL VASP

2.83e-0335322M16801
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

DIAPH1 DIAPH2 DAAM1 FMNL1 WASF2 WASF3

3.02e-03649326MM15690
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM22 WBP11 CPSF6 SF1

3.40e-03277324MM15414
PathwayREACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES

WAS VASP

3.51e-0339322M16523
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM22 WBP11 CPSF6 SF1

3.67e-03283324M13087
PathwayPID_ECADHERIN_STABILIZATION_PATHWAY

DIAPH1 VASP

3.87e-0341322M232
PathwayREACTOME_RHOF_GTPASE_CYCLE

DIAPH1 DIAPH2

3.87e-0341322MM15630
PathwayREACTOME_RHOF_GTPASE_CYCLE

DIAPH1 DIAPH2

4.06e-0342322M41821
PathwayWP_NEPHROTIC_SYNDROME

WT1 INF2

4.65e-0345322M39864
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

DIAPH1 WAS WASF2

4.67e-03150323M39520
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

DIAPH1 WAS WASF2

4.85e-03152323MM15834
PathwayWP_RETT_SYNDROME

GABBR2 SHANK3

5.28e-0348322M39759
Pubmed

Expression of multiple formins in adult tissues and during developmental stages of mouse brain.

DIAPH1 DIAPH2 FMN2 DAAM2 DAAM1 INF2 FMN1 FMNL1

6.65e-211442826272686
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

DIAPH1 DIAPH2 WASL WBP11 WAS CPSF6 CCNK FMNL1 SF1 VASP WASF2

3.39e-17154421116055720
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

DIAPH1 FMN2 WASL WBP11 INF2 ZC3H4 CPSF6 CCNK SF1 VASP WASF2

1.58e-11506421130890647
Pubmed

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.

WASL WAS WASF2 WASF3

1.28e-10842410381382
Pubmed

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex.

WASL WAS WASF2 WASF3

1.28e-10842411146629
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

WASL WAS WASF2 WASF3

1.30e-091342416723544
Pubmed

Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).

DIAPH1 DIAPH2 INF2

6.54e-09442321278336
Pubmed

FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.

WASL WASF2 WASF3

1.63e-08542314697212
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

DIAPH1 MLLT1 RBM22 WASL INF2 CPSF6 AHDC1 SF1 VASP WASF2 MEX3C

1.86e-071247421127684187
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

WASL WAS CPSF6 AHDC1 WASF2

2.34e-0711142522558309
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

WT1 RBM22 WBP11 RBM27 CPSF6 CCNK AHDC1 SF1 VASP FOXK1

5.78e-071103421034189442
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

RBM27 ZC3H4 CPSF6 CCNK AHDC1 FOXK1

8.23e-0726842633640491
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

WBP11 RBM27 ZC3H4 CPSF6 SF1

9.77e-0714842532538781
Pubmed

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.

WASL WAS

1.42e-06242211584271
Pubmed

A WASp-VASP complex regulates actin polymerization at the plasma membrane.

WAS VASP

1.42e-06242211598004
Pubmed

Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.

WASL WAS

1.42e-06242220071778
Pubmed

Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1.

DIAPH1 FMNL1

1.42e-06242216943183
Pubmed

mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.

DIAPH1 DIAPH2

1.42e-06242230256801
Pubmed

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters.

WASL WAS

1.42e-06242238085658
Pubmed

N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis.

WASL WAS

1.42e-06242220599953
Pubmed

Identification and characterization of human DAAM2 gene in silico.

DAAM2 FMNL1

1.42e-06242212632087
Pubmed

Coordination of microtubule acetylation and the actin cytoskeleton by formins.

FMN2 INF2

1.42e-06242229947928
Pubmed

Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2.

FMN1 FMNL1

1.42e-06242216480715
Pubmed

Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system.

DAAM2 DAAM1

1.42e-06242215464228
Pubmed

Wiskott-Aldrich syndrome: a comprehensive review.

WASL WAS

1.42e-06242223527602
Pubmed

The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.

DIAPH1 DIAPH2

1.42e-06242214992721
Pubmed

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2.

DAAM2 DAAM1

1.42e-06242238000028
Pubmed

Neuronal Wiskott-Aldrich syndrome protein regulates Pseudomonas aeruginosa-induced lung vascular permeability through the modulation of actin cytoskeletal dynamics.

WASL WAS

1.42e-06242231916311
Pubmed

X-ray scattering study of activated Arp2/3 complex with bound actin-WCA.

WASL WAS

1.42e-06242218462674
Pubmed

Failure of ureteric bud invasion: a new model of renal agenesis in mice.

WT1 FMN1

1.42e-06242211733383
Pubmed

Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.

DIAPH1 DIAPH2

1.42e-06242230808751
Pubmed

N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor.

WASL WASF2

1.42e-06242215496413
Pubmed

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

WASL WAS

1.42e-06242217878299
Pubmed

Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport.

DIAPH1 DIAPH2

1.42e-06242228760985
Pubmed

Diaphanous 1 and 2 regulate smooth muscle cell differentiation by activating the myocardin-related transcription factors.

DIAPH1 DIAPH2

1.42e-06242217170370
Pubmed

DAAM2 Variants Cause Nephrotic Syndrome via Actin Dysregulation.

DAAM2 INF2

1.42e-06242233232676
Pubmed

Formin family proteins in cytoskeletal control.

DAAM1 FMN1

1.42e-06242210631086
Pubmed

Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.

DIAPH1 DIAPH2

1.42e-06242221980468
Pubmed

Cellular signaling in macrophage migration and chemotaxis.

WASF2 WASF3

1.42e-06242211073096
Pubmed

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).

WASL WAS

1.42e-06242218650809
Pubmed

WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site.

WAS WASF2

1.42e-06242225342748
Pubmed

The ability to induce microtubule acetylation is a general feature of formin proteins.

FMN2 FMN1

1.42e-06242223110170
Pubmed

The mouse formin, FRLalpha, slows actin filament barbed end elongation, competes with capping protein, accelerates polymerization from monomers, and severs filaments.

FMN1 FMNL1

1.42e-06242214990563
Pubmed

The Wiskott-Aldrich syndrome protein (WASP) family.

WASF2 WASF3

1.42e-06242211246027
Pubmed

Mechanisms of actin filament severing and elongation by formins.

DIAPH1 INF2

1.42e-06242238843827
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DIAPH1 DIAPH2 WBP11 LMTK3 GABBR2 HCN2 ZC3H4 SHANK3 WASF2

1.81e-0696342928671696
Pubmed

SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.

WASF2 WASF3

4.27e-0634229732292
Pubmed

WAVE/Scars in platelets.

WASF2 WASF3

4.27e-06342215280206
Pubmed

Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function.

WASL WAS

4.27e-06342222411869
Pubmed

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

DIAPH1 VASP

4.27e-0634227737110
Pubmed

Characterization of the WAVE1 knock-out mouse: implications for CNS development.

WASF2 WASF3

4.27e-06342212716942
Pubmed

Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.

WASL WAS

4.27e-06342226463123
Pubmed

N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts.

WASL WAS

4.27e-06342217182853
Pubmed

Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin.

WASL WASF2

4.27e-06342216483316
Pubmed

Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules.

DIAPH1 INF2

4.27e-06342221998204
Pubmed

High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP.

DIAPH1 VASP

4.27e-06342218001770
Pubmed

Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons.

WASL WAS

4.27e-06342220150425
Pubmed

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

WAS WASF2

4.27e-06342221383498
Pubmed

Formin mDia1, a downstream molecule of FMNL1, regulates Profilin1 for actin assembly and spindle organization during mouse oocyte meiosis.

DIAPH1 FMNL1

4.27e-06342225447542
Pubmed

FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanisms.

DIAPH1 FMNL1

4.27e-06342239430739
Pubmed

Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling.

DIAPH2 INF2

4.27e-06342223620398
Pubmed

Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase.

DIAPH1 DAAM1

4.27e-06342220223827
Pubmed

Mechanostress resistance involving formin homology proteins: G- and F-actin homeostasis-driven filament nucleation and helical polymerization-mediated actin polymer stabilization.

DIAPH1 FMN1

4.27e-06342230309655
Pubmed

Mechanistic differences in actin bundling activity of two mammalian formins, FRL1 and mDia2.

DIAPH1 FMNL1

4.27e-06342216556604
Pubmed

Genomic organization and expression profile of the human and mouse WAVE gene family.

WASF2 WASF3

4.27e-06342212856283
Pubmed

Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein.

WAS WASF2

4.27e-06342210202051
Pubmed

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.

WASL WAS

4.27e-06342210724160
Pubmed

mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.

DIAPH1 DIAPH2

4.27e-06342227880913
Pubmed

Identification and comparative expression analyses of Daam genes in mouse and Xenopus.

DAAM2 DAAM1

4.27e-06342215533824
Pubmed

Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils.

DIAPH1 WAS

4.27e-06342219234535
Pubmed

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.

WASL WAS

4.27e-06342211340081
Pubmed

A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity.

DIAPH1 VASP

4.27e-06342212805219
Pubmed

Cdc42 interacts with the exocyst complex to promote phagocytosis.

WASL WASF2

4.27e-06342223295348
Pubmed

WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments.

WASL WASF2

4.27e-06342221769917
Pubmed

The filamentous actin cross-linking/bundling activity of mammalian formins.

DIAPH1 FMNL1

4.27e-06342218835565
Pubmed

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP.

WASL WAS

4.27e-0634229422512
Pubmed

Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.

WASL WAS

4.27e-06342219741094
Pubmed

Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage.

WASF2 WASF3

4.27e-06342215670045
Pubmed

Essential and nonredundant roles for Diaphanous formins in cortical microtubule capture and directed cell migration.

DIAPH1 DIAPH2

4.27e-06342224403606
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RBM22 WBP11 LMTK3 RBM27 ZC3H4 CPSF6 CCNK AHDC1 SF1

4.67e-06108242938697112
Pubmed

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.

DIAPH1 FMNL1 WASF3

5.85e-062942321834987
Pubmed

Disheveled-associated activator of morphogenesis 2 promotes invasion of colorectal cancer by activating PAK1 and promoting MMP7 expression.

DAAM2 DAAM1

8.53e-06442233974241
Pubmed

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.

HCN2 SHANK3

8.53e-06442226966193
Pubmed

Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.

WASL WAS

8.53e-06442222921828
Pubmed

Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion.

WASF2 WASF3

8.53e-06442219200726
Pubmed

Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein.

WASL WASF2

8.53e-0644229950691
Pubmed

mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation.

DIAPH1 WASF2

8.53e-06442222179776
Pubmed

Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.

WASL WAS

8.53e-06442222585739
Pubmed

The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis.

DIAPH1 WAS

8.53e-06442219265163
Pubmed

The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.

WASF2 WASF3

8.53e-06442217664349
Pubmed

An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries.

CPSF6 SF1

8.53e-06442217024186
Pubmed

Metastasis suppressor microRNA-335 targets the formin family of actin nucleators.

FMN2 DAAM2

8.53e-06442224223803
Pubmed

Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells.

DIAPH2 WASF2

8.53e-06442218044991
Pubmed

Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis.

DIAPH1 DIAPH2

8.53e-06442224239357
Pubmed

Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins.

FMN2 FMN1

8.53e-06442219605360
Pubmed

EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.

DIAPH1 DIAPH2

8.53e-06442223890216
Pubmed

Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase.

WAS WASF2

8.53e-06442210532312
Pubmed

N-wasp is essential for the negative regulation of B cell receptor signaling.

WASL WAS

1.42e-05542224223520
Pubmed

The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro.

WAS WASF2

1.42e-05542210427990
Pubmed

Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets.

DIAPH1 DAAM1

1.42e-05542218218625
InteractionPRPF40A interactions

DIAPH1 WASL WBP11 DAAM1 WAS CPSF6 FMN1 FMNL1 SF1 VASP WASF2 WASF3

3.80e-114464012int:PRPF40A
InteractionAPBB1 interactions

DIAPH1 DIAPH2 WASL WBP11 WAS CPSF6 SF1 VASP WASF2

1.30e-10195409int:APBB1
InteractionFHDC1 interactions

DIAPH1 DIAPH2 DAAM2 DAAM1 FMN1

2.00e-1018405int:FHDC1
InteractionACTC1 interactions

DIAPH1 FMN2 WASL WBP11 WAS INF2 ZC3H4 CPSF6 CCNK SF1 VASP WASF2 KLHL17

4.37e-106944013int:ACTC1
InteractionFMNL3 interactions

DIAPH1 DIAPH2 DAAM2 DAAM1 FMN1 FMNL1

5.42e-1049406int:FMNL3
InteractionWBP4 interactions

DIAPH1 RBM22 WBP11 WAS CPSF6 FMN1 SF1

1.79e-09109407int:WBP4
InteractionDIAPH3 interactions

DIAPH1 DIAPH2 FMN2 DAAM2 DAAM1 FMN1 FMNL1

4.69e-09125407int:DIAPH3
InteractionDAAM1 interactions

DIAPH1 DIAPH2 DAAM2 DAAM1 FMN1 FMNL1

5.86e-0972406int:DAAM1
InteractionTCERG1 interactions

DIAPH1 DIAPH2 WAS CPSF6 FMN1 FMNL1 SF1 WASF2

6.28e-09207408int:TCERG1
InteractionGAS7 interactions

DIAPH1 WAS FMNL1 SF1 WASF2

1.14e-0838405int:GAS7
InteractionDAAM2 interactions

DIAPH1 DIAPH2 DAAM2 DAAM1 FMNL1

1.14e-0838405int:DAAM2
InteractionITSN2 interactions

RBM22 WASL WAS LMTK3 CPSF6 AHDC1 WASF2

1.45e-08147407int:ITSN2
InteractionPRMT2 interactions

RBM22 WASL WBP11 SALL2 SHANK3 SF1

2.43e-0891406int:PRMT2
InteractionNCK2 interactions

WASL WBP11 WAS CPSF6 SF1 VASP WASF2 WASF3

3.94e-08262408int:NCK2
InteractionPFN1 interactions

DIAPH1 DIAPH2 FMN2 MLLT1 WASL INF2 CPSF6 FMNL1 VASP WASF2

4.15e-085094010int:PFN1
InteractionDIAPH1 interactions

DIAPH1 DIAPH2 DAAM2 WASL DAAM1 FMNL1 VASP

5.03e-08176407int:DIAPH1
InteractionFMNL1 interactions

DIAPH1 DIAPH2 DAAM2 DAAM1 FMN1 FMNL1

7.20e-08109406int:FMNL1
InteractionFMN1 interactions

FMN2 DAAM1 FMN1 FMNL1

1.15e-0723404int:FMN1
InteractionARHGAP12 interactions

WASL SHANK3 SF1 WASF2 WASF3

2.26e-0768405int:ARHGAP12
InteractionDIAPH2 interactions

DIAPH1 DIAPH2 DAAM2 DAAM1 FMNL1

2.26e-0768405int:DIAPH2
InteractionPDE6B interactions

DIAPH1 DAAM2 DAAM1 FMNL1

3.05e-0729404int:PDE6B
InteractionVASP interactions

DIAPH1 FMN2 WAS INF2 VASP FOXK1 WASF2

1.62e-06294407int:VASP
InteractionGRB2 interactions

DIAPH1 WASL WBP11 WAS HCN2 CPSF6 SHANK3 DTX1 VASP WASF2

2.82e-068064010int:GRB2
InteractionPRPF18 interactions

DIAPH1 DIAPH2 DAAM2 DAAM1 FMNL1

3.83e-06120405int:PRPF18
InteractionPACSIN1 interactions

WASL WAS SHANK3 WASF2

5.99e-0660404int:PACSIN1
InteractionARHGEF19 interactions

RBM22 WBP11 DAAM1 SF1

5.99e-0660404int:ARHGEF19
InteractionCDC42 interactions

DIAPH1 DIAPH2 FMN2 WASL DAAM1 WAS INF2 ZC3H4 FMNL1 SF1 VASP WASF2

6.08e-0613234012int:CDC42
InteractionACTG1 interactions

FMN2 WASL INF2 CPSF6 VASP WASF2 WASF3 KLHL17

6.92e-06520408int:ACTG1
InteractionNCKIPSD interactions

DIAPH2 RBM22 WASL WAS SHANK3

7.33e-06137405int:NCKIPSD
InteractionWASF2 interactions

WASL SHANK3 VASP WASF2 WASF3

9.99e-06146405int:WASF2
InteractionDVL2 interactions

DIAPH1 WT1 WASL DAAM1 WAS DTX1 VASP FOXK1

1.14e-05557408int:DVL2
InteractionPFN2 interactions

DIAPH1 INF2 SHANK3 FMNL1 VASP

1.51e-05159405int:PFN2
InteractionARPC3 interactions

WASL WAS SHANK3 VASP WASF2

2.97e-05183405int:ARPC3
InteractionFMNL2 interactions

DIAPH1 DIAPH2 DAAM2 DAAM1 FMNL1

3.13e-05185405int:FMNL2
InteractionRAC1 interactions

DIAPH1 DIAPH2 FMN2 DAAM1 WAS INF2 SHANK3 FMNL1 WASF2 WASF3

3.18e-0510634010int:RAC1
InteractionACTR2 interactions

WASL WAS RBM27 INF2 SHANK3 WASF2

3.92e-05323406int:ACTR2
InteractionBAIAP2 interactions

DIAPH1 WASL SHANK3 VASP WASF2

4.65e-05201405int:BAIAP2
InteractionKLHL12 interactions

COL8A1 CPSF6 ZBTB4 KLHL17

5.30e-05104404int:KLHL12
InteractionCRTAP interactions

COL8A1 CPSF6 AHDC1 EMID1

6.14e-05108404int:CRTAP
InteractionUBE2N interactions

LMTK3 CPSF6 SF1 DTX1 VASP MEX3C

6.23e-05351406int:UBE2N
InteractionTRIP10 interactions

WASL WBP11 WAS SHANK3

6.37e-05109404int:TRIP10
InteractionABI1 interactions

WASL SHANK3 VASP WASF2 WASF3

7.61e-05223405int:ABI1
InteractionWASF1 interactions

WASL SHANK3 WASF2 WASF3

8.12e-05116404int:WASF1
InteractionWASL interactions

DIAPH1 WASL WASF2 WASF3

8.39e-05117404int:WASL
InteractionRHOD interactions

DIAPH1 DIAPH2 FMN2 DAAM1 INF2 FMNL1 WASF2

1.18e-04572407int:RHOD
InteractionCEBPA interactions

WT1 RBM22 WBP11 RBM27 CPSF6 CCNK AHDC1 SF1 VASP FOXK1

1.20e-0412454010int:CEBPA
InteractionHOMER3 interactions

RBM22 SHANK3 WASF2 ZBTB4

1.68e-04140404int:HOMER3
InteractionFYN interactions

DIAPH1 WASL WBP11 WAS FMN1 WASF2

1.92e-04431406int:FYN
InteractionWASF3 interactions

WASL WASF2 WASF3

1.97e-0457403int:WASF3
InteractionABI2 interactions

WASL SHANK3 VASP WASF2 WASF3

2.44e-04286405int:ABI2
InteractionCELF1 interactions

WBP11 RBM27 ZC3H4 CPSF6 SF1

2.51e-04288405int:CELF1
InteractionDHX8 interactions

WBP11 SALL2 RBM27 CPSF6 CCNK

2.68e-04292405int:DHX8
InteractionFMN2 interactions

FMN2 FMN1 VASP

2.78e-0464403int:FMN2
InteractionWBP11 interactions

COL8A1 WBP11 CPSF6 SHANK3

2.80e-04160404int:WBP11
InteractionHCN2 interactions

HCN2 SHANK3

2.95e-0413402int:HCN2
InteractionSOWAHB interactions

DIAPH1 DIAPH2

2.95e-0413402int:SOWAHB
InteractionSHANK3 interactions

WBP11 ZCCHC2 LMTK3 HCN2 SHANK3 WASF2

4.07e-04496406int:SHANK3
InteractionCYFIP2 interactions

DIAPH2 SHANK3 VASP WASF2 WASF3

4.26e-04323405int:CYFIP2
InteractionALG13 interactions

CPSF6 CCNK SF1 VASP

4.66e-04183404int:ALG13
InteractionCUL4B interactions

RBM22 SALL2 WAS LMTK3 CPSF6 SF1 VASP

5.14e-04728407int:CUL4B
InteractionABI3 interactions

WAS VASP WASF2

5.55e-0481403int:ABI3
InteractionDOCK1 interactions

DIAPH2 WASF2 KLHL17

5.75e-0482403int:DOCK1
InteractionHDAC4 interactions

DIAPH1 FMN2 LMTK3 CPSF6 FMN1 SF1 WASF2

5.85e-04744407int:HDAC4
InteractionEVL interactions

WAS VASP WASF2

5.96e-0483403int:EVL
InteractionHNRNPUL1 interactions

RBM22 CPSF6 MAPK1IP1L SF1 FOXK1

6.21e-04351405int:HNRNPUL1
InteractionKCTD10 interactions

CPSF6 FMNL1 SF1 WASF2

6.26e-04198404int:KCTD10
InteractionCAPN13 interactions

ZC3H4 SF1

6.43e-0419402int:CAPN13
InteractionJMJD6 interactions

WAS RBM27 ZC3H4 CPSF6

7.13e-04205404int:JMJD6
InteractionMECP2 interactions

RBM22 WBP11 LMTK3 RBM27 ZC3H4 CPSF6 CCNK AHDC1 SF1

7.74e-041287409int:MECP2
InteractionMEN1 interactions

WT1 COL8A1 ZC3H4 CPSF6 CCNK AHDC1 SF1 FOXK1

8.03e-041029408int:MEN1
InteractionEZH1 interactions

WBP11 RBM27 ZC3H4

8.05e-0492403int:EZH1
InteractionDMRTB1 interactions

RBM22 SF1 VASP

8.57e-0494403int:DMRTB1
InteractionLINC02910 interactions

WBP11 RBM27 ZC3H4

8.84e-0495403int:LINC02910
InteractionPSTPIP1 interactions

WASL WAS WASF2

9.39e-0497403int:PSTPIP1
InteractionZCCHC2 interactions

ZCCHC2 SHANK3

9.47e-0423402int:ZCCHC2
InteractionABHD10 interactions

SHANK3 SF1 FOXK1

1.06e-03101403int:ABHD10
InteractionACTB interactions

DIAPH1 FMN2 WASL DAAM1 INF2 VASP WASF2 WASF3

1.12e-031083408int:ACTB
InteractionAPBB1IP interactions

VASP WASF2

1.12e-0325402int:APBB1IP
InteractionPQBP1 interactions

RBM22 WBP11 CPSF6

1.18e-03105403int:PQBP1
InteractionANKRD28 interactions

INF2 SHANK3 VASP FOXK1

1.18e-03235404int:ANKRD28
InteractionRHOB interactions

DIAPH1 DIAPH2 FMN2 DGKD DAAM1 FMNL1 WASF2

1.19e-03840407int:RHOB
InteractionMETTL22 interactions

SF1 FOXK1

1.21e-0326402int:METTL22
InteractionCCNL2 interactions

DIAPH1 DAAM1 FMNL1

1.21e-03106403int:CCNL2
InteractionHCN1 interactions

GABBR2 HCN2 SHANK3

1.28e-03108403int:HCN1
InteractionEYA4 interactions

CPSF6 CCNK MAPK1IP1L SF1

1.34e-03243404int:EYA4
InteractionBCR interactions

INF2 CPSF6 SHANK3 VASP

1.36e-03244404int:BCR
InteractionNCK1 interactions

WASL WAS SHANK3 WASF2

1.36e-03244404int:NCK1
InteractionPPP1R7 interactions

WBP11 LMTK3 SHANK3

1.39e-03111403int:PPP1R7
InteractionSORBS2 interactions

WASL WAS SHANK3

1.39e-03111403int:SORBS2
InteractionNUP35 interactions

RBM22 RBM27 CPSF6 AHDC1 FOXK1

1.44e-03424405int:NUP35
InteractionNHSL3 interactions

VASP WASF2 WASF3

1.46e-03113403int:NHSL3
InteractionSNRNP40 interactions

RBM22 WBP11 ZC3H4 CPSF6 AHDC1 ZBTB4

1.50e-03637406int:SNRNP40
InteractionSNRPB2 interactions

RBM22 WBP11 CPSF6 SF1

1.60e-03255404int:SNRPB2
InteractionKRTAP19-7 interactions

COL8A1 CCNK MAPK1IP1L

1.61e-03117403int:KRTAP19-7
InteractionCEP55 interactions

COL8A1 RBM22 MAPK1IP1L SF1

1.62e-03256404int:CEP55
Cytoband19q13.32

ZC3H4 VASP

2.12e-037442219q13.32
GeneFamilyWiskott-Aldrich Syndrome protein family

WASL WAS WASF2 WASF3

9.58e-091629414
GeneFamilyZinc fingers CCCH-type

RBM22 RBM27 ZC3H4

2.35e-053529373
GeneFamilyZinc fingers CCHC-type|RNA binding motif containing

ZCCHC2 SF1

7.28e-042529274
GeneFamilyRNA binding motif containing

RBM22 RBM27 CPSF6

4.70e-03213293725
GeneFamilySterile alpha motif domain containing

DGKD SHANK3

8.73e-0388292760
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB4 KLHL17

1.94e-02134292861
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

WT1 SALL2 ZIC5 ZBTB4

2.66e-0271829428
CoexpressionGSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_DN

DIAPH1 DIAPH2 WAS SF1 WASF2

1.66e-05200425M7080
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 FMN2 WASL INF2

1.37e-0515542490e629681a72baacc7981b82883866a487638dbc
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 FMN2 WASL INF2

1.37e-05155424e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 FMN2 WASL INF2

1.37e-051554245a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 DAAM2 ZFTA EMID1

2.21e-0517542412f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAAM2 COL8A1 HCN2 EMID1

2.26e-05176424e2b59a904c5c8f9c88e1e63788e9b6485f22edd0
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAAM2 COL8A1 HCN2 EMID1

2.26e-05176424f931192e3cc65414e2245354f443473696cc7ce8
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 ZC3H4 AHDC1 EMID1

2.31e-051774247c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 ZC3H4 AHDC1 EMID1

2.31e-05177424e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DAAM2 COL8A1 RBM27 EMID1

2.36e-0517842409475e522dc1b8cf9ff1c25de5d1e3082b162948
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DAAM2 COL8A1 RBM27 EMID1

2.36e-0517842435de8f791b0e78a6caf52ff095f05e204a59e828
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DAAM2 COL8A1 RBM27 EMID1

2.36e-05178424000d25f3f13cc76cf39c46c312c6fafc2ea4f368
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_Erythro-Mega|lymph-node_spleen / Manually curated celltypes from each tissue

WT1 AHDC1 SHANK3 EMID1

2.41e-05179424957c08ad4b46eb4cc1717c45056fc3db50015fdc
ToppCell3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic-Meg|bone_marrow / Manually curated celltypes from each tissue

WT1 SHANK3 EMID1 WASF3

2.46e-0518042444ba37bead1ac39bce4d3eef00961063c50ced0d
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 COL8A1 HCN2 EMID1

2.57e-051824249edaccf1154cec92ca9a28e9b1f9075cfd422bfd
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 COL8A1 HCN2 EMID1

2.57e-05182424aba4c06d5d7618ac21b2695bca8e7a1346a91090
ToppCellwk_08-11-Epithelial-PNS-PCP4+_neuron|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

FMN2 MMP24 HCN2 DTX1

2.68e-05184424eac2a9089913f33a961ba11519b53645790f2056
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAAM2 COL8A1 HCN2 EMID1

2.68e-0518442439bb0eb55bdc2cea46e41c7f21d8c5883f14e6bd
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAAM2 COL8A1 HCN2 EMID1

2.68e-051844244cb5f299dd7413e0be1ad7af817ee614b23a18ae
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIAPH1 DIAPH2 WAS WASF2

2.74e-051854247adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FMN2 GLDN EMID1 KLHL17

2.92e-05188424c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

DAAM2 GLDN EMID1 WASF3

3.50e-05197424b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

DAAM2 GLDN EMID1 WASF3

3.50e-051974245afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

DAAM2 GLDN EMID1 WASF3

3.50e-051974241baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

COL8A1 GLDN DAAM1 EMID1

3.50e-05197424f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellBiopsy_Control_(H.)-Immune|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

GLDN WAS FMNL1 VASP

3.72e-05200424e1d50556ca116ef4b65ec29ab2ef7341f0d21451
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 FMN2 COL8A1

4.25e-04156423abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 FMN2 COL8A1

4.25e-04156423dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DAAM2 RBM22 DTX1

4.33e-04157423f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 DAAM2 EMID1

4.49e-041594235ca96db4281abb5f646150ccf36adc66ab201c78
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DAAM2 COL8A1 EMID1

4.49e-041594232607b562903228274fbd96168ba826782fab0b53
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DAAM2 COL8A1 EMID1

4.49e-04159423e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 DAAM2 EMID1

4.66e-041614231b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCellAT1_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

MMP24 COL8A1 WASF3

4.75e-04162423ae2ba4f21f6f6c512006fa531d670b88be7c04c9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 DAAM2 EMID1

4.92e-04164423f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHANK3 DTX1 EMID1

5.01e-04165423347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHANK3 DTX1 EMID1

5.01e-041654231890f9c33b0c5b381d57f97042da2610a093a6de
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMN1 DTX1 EMID1

5.01e-041654238c7a6f9e2ca0ce077426d3d0726e3f5a4c03b296
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHANK3 DTX1 EMID1

5.01e-04165423507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHANK3 DTX1 EMID1

5.01e-0416542339a25be081a5d59c7cf107a997d352793d5025fb
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

LMTK3 SHANK3 FMNL1

5.18e-041674239efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 WAS EMID1

5.18e-04167423b4ef07117d14da3d5fbced949e4dfcb01c392295
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

LMTK3 SHANK3 FMNL1

5.18e-04167423904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 WAS EMID1

5.18e-0416742394fc7df7ca55cd722a8dbd153201a29891217473
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 WAS EMID1

5.18e-04167423eff3723fe60755272eca237459165e436e919ece
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GABBR2 DTX1 EMID1

5.37e-04169423f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-B_cells-Pro-B|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WAS FMNL1 DTX1

5.37e-041694237fd13b6e6041032697d36dd215f6b943d4675cf2
ToppCellEndothelial-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ZIC5 SHANK3 DTX1

5.37e-0416942395c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-B_cells|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WAS FMNL1 DTX1

5.46e-04170423e319ab46842d028898c09d6d8f056f896edb1558
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GABBR2 DTX1 EMID1

5.46e-0417042335e3945d8a540a3e2cec1b559316265aaad023d1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 DAAM2 EMID1

5.46e-04170423876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GABBR2 DTX1 EMID1

5.46e-041704230ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 DAAM2 EMID1

5.46e-041704231f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GABBR2 DTX1 EMID1

5.46e-041704230b5ddc7d452db0a389927a367914f7d257703f7e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 SALL2 WAS

5.55e-04171423f047a0cc2ce0a062ec502aa9cb91b1202f437f29
ToppCellmetastatic_Brain-B_lymphocytes-Undetermined|B_lymphocytes / Location, Cell class and cell subclass

SALL2 HCN2 FMN1

5.55e-041714230d14bc9688c427ba2265984987dc3eea195b19eb
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

WBP11 SHANK3 EMID1

5.55e-041714231ae4b6a25bc9c1065cf5d95998ebcc70aee21ab5
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WT1 DAAM2 SHANK3

5.65e-04172423073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 FMN2 INF2

5.65e-041724236c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 DAAM2 EMID1

5.65e-04172423553701349444eb366df3c11f54bb093434f153c6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 DAAM2 EMID1

5.65e-0417242308a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 FMN2 INF2

5.65e-04172423381ae1c3c07d0a424f43455ec571653b192a946a
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DTX1 EMID1 WASF3

5.74e-041734237dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCellfacs-Lung-EPCAM-18m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WAS FMNL1 VASP

5.74e-0417342350b25b7f8f29b60c22782a4492fe4b089fe7d69d
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL8A1 HCN2 EMID1

5.74e-04173423cbd65dd5b01cc959e3ccbc89330ddd0122296ea3
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL8A1 HCN2 EMID1

5.74e-04173423f9d6e892d66f9b94e4d5beb9f5dec9b606bc868a
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

COL8A1 SALL2 EMID1

5.74e-0417342375e26a65071b0d2f30ed0b2aa9859c488f5cf362
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

COL8A1 SALL2 EMID1

5.74e-0417342326e2e674f5d312fa8f61c11b553dc6101f063b16
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GLDN ZCCHC2 FMNL1

5.84e-04174423d5c22b43531414951666ee7542a66ed9380e2d14
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 FMN2 INF2

5.84e-04174423dbdcdec08f1fc69fcdb5d8a6d78df8ef9c374d89
ToppCellfacs-Heart-RV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 VASP EMID1

5.94e-04175423bfac175b79bb7d3d81074a2407c206a7647ee75d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DAAM2 DGKD GLDN

5.94e-04175423d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 COL8A1 EMID1

5.94e-04175423a7310950e8d51b3004ea3aee8ce9948fe8655112
ToppCell11.5-Distal-Immune-Hematopoietic,_B_Cells|Distal / Age, Tissue, Lineage and Cell class

WAS FMNL1 DTX1

5.94e-04175423d8ca8fbe5309dab293c335b32f1b138edfdd0b07
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL8A1 HCN2 WASF3

5.94e-041754238362a46f5804333baa84cd56d450bc147f372a7e
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 COL8A1 EMID1

5.94e-04175423d2ff8fedca9039cbd45cfd9dec88f4edbe7fe4fc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DAAM2 DGKD GLDN

5.94e-04175423454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCellP15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ZIC5 DTX1 EMID1

5.94e-0417542384d252f3e432231687613299bbea14978bb4b06b
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL8A1 HCN2 WASF3

5.94e-041754238b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCellfacs-Heart-RV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 VASP EMID1

5.94e-04175423c94fb35bbac95123201ca87ca835aecaefc0c490
ToppCellP15-Endothelial-lymphatic_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ZIC5 DTX1 EMID1

5.94e-04175423a00c6fa9b33640710dd05a3799031147196f0986
ToppCellwk_08-11-Hematologic_Lymphocytic-B-Large_pre-B|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

WAS FMNL1 DTX1

6.04e-0417642378417a5ac2e45e97e7b4c56c78c25879a1b58f97
ToppCell3'_v3-blood-Hematopoietic_progenitors|blood / Manually curated celltypes from each tissue

WT1 SHANK3 EMID1

6.14e-0417742322c77077951889e63489abfabf90900655655c82
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 LMTK3 SHANK3

6.14e-041774238ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCellfacs-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAAM2 COL8A1 EMID1

6.24e-041784238bae5db100f4563aa1fc7f881e7f8c59d669e37a
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIAPH1 DIAPH2 WASF2

6.24e-0417842301dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DIAPH2 ZFTA MEX3C

6.24e-04178423c87945146b2734141f07b39d268e0d8086ee0364
ToppCellfacs-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAAM2 COL8A1 EMID1

6.24e-04178423bc0336692b84bd0fa49747ed5a031b8ed8afa0fd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 FMN2 INF2

6.24e-04178423edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 COL8A1 EMID1

6.34e-04179423bfc226bcf0b93525992344f968268a261d86fcbf
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WT1 HCN2 EMID1

6.34e-041794239dd8d19050223cdebec2579014892b759e5e9de8
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WT1 MMP24 COL8A1

6.34e-04179423056df2aaff750e0e283e7da78fcc3c90c366aac0
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 COL8A1 EMID1

6.34e-0417942336ad18f52e175ab636ceaa3be81212fa362c96c1
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WT1 MMP24 COL8A1

6.34e-04179423f5f3945ef3b9efc5921a71fd51deeb2c80f0ce11
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WAS HCN2 FMNL1

6.34e-04179423dd3cf8fd10dc257d933a7f45860dc2e244c158b7
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells-Pre-B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DGKD FMNL1 DTX1

6.34e-04179423dc0b806904ef4c2f74f34ade2b1c0d6893f3b2ec
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 COL8A1 EMID1

6.45e-041804230153667e44fdbc3c0d444dcb023069925a2b69a2
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAAM2 COL8A1 EMID1

6.45e-0418042340a28b410f46215d6d7cf8a02a18078eb046b5b0
ToppCellfacs-Lung-18m-Mesenchymal-myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAAM2 COL8A1 EMID1

6.55e-04181423dff264815a3569f5666d0bbc3867c0496cd78774
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 DAAM2 EMID1

6.55e-04181423a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FMN2 COL8A1 SALL2

6.55e-04181423ab0f300d14b62cef57f1b0bdae143b8dfe8e6975
DrugAC1LD8HW

DIAPH1 DIAPH2 DAAM2 DAAM1 WAS FMN1 FMNL1 VASP

1.02e-1275428CID000644061
Drugmethenamine silver

DIAPH1 DIAPH2 MLLT1 DAAM2 DAAM1 WAS FMN1 FMNL1 VASP

9.43e-11201429CID000004101
DrugF-dd

DIAPH1 DIAPH2 DAAM2 DAAM1 FMN1 FMNL1

7.95e-0981426CID006102682
DrugC18:1n-7

WASL WAS VASP WASF2 WASF3

7.30e-0792425CID000122325
Drug3 SA

WASL WAS WASF2 WASF3

9.64e-0741424CID000449164
Drug(1Z)-2-methylbutanal oxime

WT1 WAS

9.95e-063422CID005362772
DrugAC1L1S5D

WT1 WAS

9.95e-063422CID000009023
DrugC3H2N2O3S

DIAPH1 DIAPH2 WASL WAS

1.05e-0574424CID000448652
DrugmDia

DIAPH1 DIAPH2 WASL VASP

2.59e-0593424CID000128346
Drug5213008; Up 200; 18uM; MCF7; HT_HG-U133A_EA

DIAPH1 DIAPH2 COL8A1 WAS VASP

2.81e-05194425898_UP
Drugetheno-NAD

WASL WAS VASP WASF2

4.02e-05104424CID005288160
DrugAC1OAGFB

DGKD WASL WAS HCN2 VASP WASF2 WASF3

5.27e-05539427CID006857345
Diseaseautosomal dominant auditory neuropathy 1 (implicated_via_orthology)

DIAPH1 DIAPH2

5.65e-063412DOID:0060690 (implicated_via_orthology)
DiseaseWiskott-Aldrich syndrome (implicated_via_orthology)

WASL WAS

1.13e-054412DOID:9169 (implicated_via_orthology)
DiseaseHereditary Nephrotic Syndromes, Autosomal Dominant

WT1 INF2

1.03e-0411412cv:CN043612
DiseaseFamilial idiopathic steroid-resistant nephrotic syndrome

WT1 INF2

1.46e-0413412cv:C4273714
DiseaseRenal glomerular disease

WT1 INF2

4.68e-0423412C0268731
DiseaseGlomerulopathy Assessment

WT1 INF2

4.68e-0423412C4521256
DiseaseBilateral Wilms Tumor

WT1 MLLT1

7.47e-0429412C2930471
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

WT1 INF2

7.99e-0430412C1868672
DiseaseNephroblastoma

WT1 MLLT1

1.15e-0336412C0027708
Diseaseurate measurement, bone density

DIAPH1 DGKD SALL2 HCN2 MEX3C

1.61e-03619415EFO_0003923, EFO_0004531

Protein segments in the cluster

PeptideGeneStartEntry
PPGGQPPVPPPIPPP

CCNK

551

O75909
GPPGPPGPPGPPGPP

GLDN

236

Q6ZMI3
PPPPPPPPALPGPGP

AHDC1

431

Q5TGY3
PPPPPPPPPPLPGGV

DIAPH1

611

O60610
PPPPLPGGPGIPPPP

DIAPH1

716

O60610
PLPGVGPPPPPPAPP

DIAPH2

556

O60879
GPPPPPPAPPLPGGA

DIAPH2

561

O60879
PPPPPPPLLFGGPPP

DIAPH2

591

O60879
PPPPGIAPPPPPGFG

RBM22

366

Q9NW64
FPPPPPGLPPPPPPG

RBM27

316

Q9P2N5
PPNPGGPPPAPPPPG

FMN1

936

Q68DA7
GPPPAPPPPGLAPPP

FMN1

941

Q68DA7
CCPPPPPPPLPPGGP

DAAM2

551

Q86T65
PPPPLPPGGPPTPPG

DAAM2

556

Q86T65
PGPPPPPPPPGQAPR

MMP24

11

Q9Y5R2
PPRPPPPPPPPRDGP

LMTK3

416

Q96Q04
GRGPPPAPPPPPPPP

LMTK3

746

Q96Q04
APPAPPLPPPPPPGG

DTX1

226

Q86Y01
PPPLPGLGCPPPPPP

INF2

491

Q27J81
PPPPPPLPGGMLPPP

DAAM1

551

Q9Y4D1
MLPPPPPPLPPGGPP

DAAM1

561

Q9Y4D1
PPPLPPGGPPPPPGP

DAAM1

566

Q9Y4D1
GPGPEAPPPPPPQPP

KLHL17

21

Q6TDP4
PPRPPLGPPGPPGPP

CPSF6

236

Q16630
LGPPGPPGPPGPPPP

CPSF6

241

Q16630
PPPPVPGYGPPPGPP

CPSF6

296

Q16630
PPPPPGPFPPRPPGP

CPSF6

316

Q16630
GPPPPPPPPLPPGAI

FOXK1

51

P85037
PPGPPGPPGPPAVMP

COL8A1

561

P27658
PPPPPPPPPPGTDGP

FMNL1

586

O95466
PPPPPGTDGPVPPPP

FMNL1

591

O95466
GTDGPVPPPPPPPPP

FMNL1

596

O95466
GAPPPGPPQPPPPPP

DGKD

6

Q16760
SSGQPGPPPPPPPPP

GABBR2

6

O75899
PPGPPGPPGPPGPPA

EMID1

246

Q96A84
TSPKGGPPPPPPPPP

MLLT1

266

Q03111
PPPPLPGAGIPPPPP

FMN2

911

Q9NZ56
PPPPPLPGAGIPPPP

FMN2

976

Q9NZ56
PPPPLPGAGIPPPPP

FMN2

1021

Q9NZ56
PPPPPLPGAGIPPPP

FMN2

1031

Q9NZ56
PPPPLPGAGIPPPPP

FMN2

1076

Q9NZ56
PPPPPLPGAGIPPPP

FMN2

1086

Q9NZ56
PPPPLPGAGIPPPPP

FMN2

1131

Q9NZ56
PPPPPLPGAGIPPPP

FMN2

1196

Q9NZ56
PPPPPPPPPPGVGSG

SALL2

161

Q9Y467
PPPPPPAPPPGPGPA

HCN2

36

Q9UL51
PPTGPPPGPPAPFPP

MAPK1IP1L

76

Q8NDC0
PPPPPPLPPPSGGPE

MEX3C

26

Q5U5Q3
GPLPPPPPPRGLGPP

ZCCHC2

56

Q9C0B9
PGPGPAPPAPPAPPP

SHANK3

446

Q9BYB0
PPPGPPPPPPGPPGP

WASF3

396

Q9UPY6
LPPPPPGAGGPPMPP

WAS

381

P42768
PGAGGPPMPPPPPPP

WAS

386

P42768
PPPPPPPPPSSGNGP

WAS

396

P42768
LGGPAPPPAPPPPPP

WT1

51

P19544
PPGPPPAPEPGPPPS

ZBTB4

456

Q9P1Z0
PMQGGPPPPPPPPPP

ZC3H4

536

Q9UPT8
PTGGAPPPPPPPPPP

WASF2

386

Q9Y6W5
PPPPPGPPPPPFTGA

WASF2

396

Q9Y6W5
APPPPPPSRGGPPPP

WASL

276

O00401
PPSRGGPPPPPPPPH

WASL

281

O00401
GPPPPPPPPHNSGPP

WASL

286

O00401
PMPGPPPLGPPPAPP

WBP11

406

Q9Y2W2
PPTGLPPGPPPGAPP

WBP11

426

Q9Y2W2
GPPPGRPPGPPPGPP

WBP11

461

Q9Y2W2
RPPGPPPGPPPGLPP

WBP11

466

Q9Y2W2
PPGPPPGLPPGPPPR

WBP11

471

Q9Y2W2
PPPPPSGQPPPPPSG

SF1

481

Q15637
GGLALPPPPPPPPPP

ZFTA

556

C9JLR9
PAGGPPPPPGPPPPP

VASP

166

P50552
PPPPPPPPPAGGAKP

ZIC5

416

Q96T25