Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H4K20 methyltransferase activity	NSD2 NSD1 SMYD5	1.18e-05	10	94	3	GO:0042799
GeneOntologyMolecularFunction	histone H4 methyltransferase activity	NSD2 NSD1 SMYD5	6.55e-05	17	94	3	GO:0140939
GeneOntologyMolecularFunction	pyruvate dehydrogenase (acetyl-transferring) activity	PDHA1 PDHA2	6.56e-05	3	94	2	GO:0004739
GeneOntologyMolecularFunction	histone H3K36 dimethyltransferase activity	NSD2 NSD1	1.31e-04	4	94	2	GO:0140954
GeneOntologyMolecularFunction	pyruvate dehydrogenase (NAD+) activity	PDHA1 PDHA2	3.25e-04	6	94	2	GO:0034604
GeneOntologyMolecularFunction	pyruvate dehydrogenase [NAD(P)+] activity	PDHA1 PDHA2	3.25e-04	6	94	2	GO:0034603
GeneOntologyMolecularFunction	pyruvate dehydrogenase activity	PDHA1 PDHA2	3.25e-04	6	94	2	GO:0004738
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	PDHA1 PDHA2	7.73e-04	9	94	2	GO:0016624
Domain	Zinc_finger_PHD-type_CS	NSD2 NSD1 KDM5D SP140L SP140	1.89e-05	65	94	5	IPR019786
Domain	Pyrv_DH_E1_asu_subgrp-y	PDHA1 PDHA2	2.51e-05	2	94	2	IPR017597
Domain	PHD	NSD2 NSD1 KDM5D SP140L SP140	3.79e-05	75	94	5	PF00628
Domain	Znf_C2H2	ZBTB38 ZNF585A ZNF695 CBLL2 MAZ ZFY ZNF585B RLF ZNF610 GTF2H2 ZNF451 ZNF540 ZNF81 ZNF512	4.83e-05	805	94	14	IPR007087
Domain	Znf_PHD-finger	NSD2 NSD1 KDM5D SP140L SP140	4.87e-05	79	94	5	IPR019787
Domain	PHD	NSD2 NSD1 KDM5D SP140L SP140	8.62e-05	89	94	5	SM00249
Domain	Znf_PHD	NSD2 NSD1 KDM5D SP140L SP140	9.59e-05	91	94	5	IPR001965
Domain	VWC_out	FRAS1 FCGBP MUC6	1.13e-04	19	94	3	SM00215
Domain	ZF_PHD_2	NSD2 NSD1 KDM5D SP140L SP140	1.18e-04	95	94	5	PS50016
Domain	ZF_PHD_1	NSD2 NSD1 KDM5D SP140L SP140	1.24e-04	96	94	5	PS01359
Domain	ZINC_FINGER_C2H2_2	ZBTB38 ZNF585A ZNF695 CBLL2 MAZ ZFY ZNF585B RLF ZNF610 ZNF451 ZNF540 ZNF81 ZNF512	1.32e-04	775	94	13	PS50157
Domain	PWWP	NSD2 NSD1 MSH6	1.32e-04	20	94	3	SM00293
Domain	ZINC_FINGER_C2H2_1	ZBTB38 ZNF585A ZNF695 CBLL2 MAZ ZFY ZNF585B RLF ZNF610 ZNF451 ZNF540 ZNF81 ZNF512	1.36e-04	777	94	13	PS00028
Domain	Znf_C2H2-like	ZBTB38 ZNF585A ZNF695 CBLL2 MAZ ZFY ZNF585B RLF ZNF610 ZNF451 ZNF540 ZNF81 ZNF512	1.72e-04	796	94	13	IPR015880
Domain	zf-C2H2	ZBTB38 ZNF585A ZNF695 MAZ ZFY ZNF585B RLF ZNF610 ZNF451 ZNF540 ZNF81 ZNF512	1.83e-04	693	94	12	PF00096
Domain	ZnF_C2H2	ZBTB38 ZNF585A ZNF695 CBLL2 MAZ ZFY ZNF585B RLF ZNF610 ZNF451 ZNF540 ZNF81 ZNF512	1.99e-04	808	94	13	SM00355
Domain	PWWP	NSD2 NSD1 MSH6	2.03e-04	23	94	3	PF00855
Domain	PWWP_dom	NSD2 NSD1 MSH6	2.03e-04	23	94	3	IPR000313
Domain	PWWP	NSD2 NSD1 MSH6	2.31e-04	24	94	3	PS50812
Domain	AWS	NSD2 NSD1	2.48e-04	5	94	2	SM00570
Domain	RDM	RFPL4AL1 RFPL4A	2.48e-04	5	94	2	PF11002
Domain	RDM_domain_RFPL	RFPL4AL1 RFPL4A	2.48e-04	5	94	2	IPR022723
Domain	AWS	NSD2 NSD1	2.48e-04	5	94	2	PS51215
Domain	AWS_dom	NSD2 NSD1	2.48e-04	5	94	2	IPR006560
Domain	HSR	SP140L SP140	2.48e-04	5	94	2	PS51414
Domain	HSR	SP140L SP140	2.48e-04	5	94	2	PF03172
Domain	HSR_dom	SP140L SP140	2.48e-04	5	94	2	IPR004865
Domain	DUF3398	DOCK8 DOCK7	3.71e-04	6	94	2	PF11878
Domain	E1_dh	PDHA1 PDHA2	3.71e-04	6	94	2	PF00676
Domain	Tyr_kinase_CSF1/PDGF_rcpt	FLT3 PDGFRB	3.71e-04	6	94	2	IPR016243
Domain	DOCK_C/D_N	DOCK8 DOCK7	3.71e-04	6	94	2	IPR021816
Domain	DH_E1	PDHA1 PDHA2	3.71e-04	6	94	2	IPR001017
Domain	-	CBLL2 NSD2 NSD1 TRIM65 KDM5D RFPL4AL1 RFPL4A SP140L SP140	4.33e-04	449	94	9	3.30.40.10
Domain	Znf_RING/FYVE/PHD	CBLL2 NSD2 NSD1 TRIM65 KDM5D RFPL4AL1 RFPL4A SP140L SP140	5.07e-04	459	94	9	IPR013083
Domain	SAND_dom	SP140L SP140	6.88e-04	8	94	2	IPR000770
Domain	Tyr_kinase_rcpt_3_CS	FLT3 PDGFRB	6.88e-04	8	94	2	IPR001824
Domain	SAND	SP140L SP140	6.88e-04	8	94	2	PF01342
Domain	RECEPTOR_TYR_KIN_III	FLT3 PDGFRB	6.88e-04	8	94	2	PS00240
Domain	SAND	SP140L SP140	6.88e-04	8	94	2	PS50864
Domain	SAND	SP140L SP140	6.88e-04	8	94	2	SM00258
Domain	Znf_FYVE_PHD	NSD2 NSD1 KDM5D SP140L SP140	8.83e-04	147	94	5	IPR011011
Domain	TyrKc	EPHB3 FLT3 PDGFRB ZAP70	1.02e-03	88	94	4	SM00219
Domain	Tyr_kinase_cat_dom	EPHB3 FLT3 PDGFRB ZAP70	1.02e-03	88	94	4	IPR020635
Domain	SET	NSD2 NSD1 SMYD5	1.15e-03	41	94	3	PF00856
Domain	VWF_dom	FRAS1 FCGBP MUC6	1.23e-03	42	94	3	IPR001007
Domain	Znf_RING	CBLL2 NSD2 NSD1 TRIM65 RFPL4AL1 RFPL4A GTF2H2	1.29e-03	326	94	7	IPR001841
Domain	DOCK_C	DOCK8 DOCK7	1.34e-03	11	94	2	IPR010703
Domain	DHR-1_domain	DOCK8 DOCK7	1.34e-03	11	94	2	IPR027007
Domain	DHR_2	DOCK8 DOCK7	1.34e-03	11	94	2	PS51651
Domain	DHR_1	DOCK8 DOCK7	1.34e-03	11	94	2	PS51650
Domain	DOCK-C2	DOCK8 DOCK7	1.34e-03	11	94	2	PF14429
Domain	DHR-2	DOCK8 DOCK7	1.34e-03	11	94	2	IPR027357
Domain	DHR-2	DOCK8 DOCK7	1.34e-03	11	94	2	PF06920
Domain	DOCK	DOCK8 DOCK7	1.34e-03	11	94	2	IPR026791
Domain	PROTEIN_KINASE_TYR	EPHB3 FLT3 PDGFRB ZAP70	1.46e-03	97	94	4	PS00109
Domain	Tyr_kinase_AS	EPHB3 FLT3 PDGFRB ZAP70	1.46e-03	97	94	4	IPR008266
Domain	TIL	FCGBP MUC6	1.60e-03	12	94	2	PF01826
Domain	-	SP140L SP140	1.60e-03	12	94	2	3.10.390.10
Domain	SAND_dom-like	SP140L SP140	1.60e-03	12	94	2	IPR010919
Domain	C8	FCGBP MUC6	1.60e-03	12	94	2	PF08742
Domain	SET	NSD2 NSD1 SMYD5	1.60e-03	46	94	3	SM00317
Domain	Unchr_dom_Cys-rich	FCGBP MUC6	1.89e-03	13	94	2	IPR014853
Domain	THDP-binding	PDHA1 PDHA2	1.89e-03	13	94	2	IPR029061
Domain	-	PDHA1 PDHA2	1.89e-03	13	94	2	3.40.50.970
Domain	C8	FCGBP MUC6	1.89e-03	13	94	2	SM00832
Domain	SET_dom	NSD2 NSD1 SMYD5	2.04e-03	50	94	3	IPR001214
Domain	SET	NSD2 NSD1 SMYD5	2.04e-03	50	94	3	PS50280
Domain	-	ZBTB38 ZNF585A ZNF695 MAZ ZFY ZNF585B RLF ZNF610 ZNF540 ZNF81	2.19e-03	679	94	10	3.30.160.60
Domain	TIL_dom	FCGBP MUC6	2.19e-03	14	94	2	IPR002919
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB38 ZNF585A ZNF695 MAZ ZFY ZNF585B RLF ZNF610 ZNF540 ZNF81	2.56e-03	694	94	10	IPR013087
Domain	Post-SET_dom	NSD2 NSD1	2.87e-03	16	94	2	IPR003616
Domain	VWD	FCGBP MUC6	2.87e-03	16	94	2	SM00216
Domain	PostSET	NSD2 NSD1	2.87e-03	16	94	2	SM00508
Domain	VWF_type-D	FCGBP MUC6	2.87e-03	16	94	2	IPR001846
Domain	VWFD	FCGBP MUC6	2.87e-03	16	94	2	PS51233
Domain	POST_SET	NSD2 NSD1	2.87e-03	16	94	2	PS50868
Domain	VWD	FCGBP MUC6	2.87e-03	16	94	2	PF00094
Domain	Pkinase_Tyr	EPHB3 FLT3 PDGFRB ZAP70	4.10e-03	129	94	4	PF07714
Domain	ConA-like_dom	TRIM65 CLSTN1 RFPL4AL1 RFPL4A NRXN3	5.00e-03	219	94	5	IPR013320
Pubmed	Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins.	CBLL2 NSD2 TRIM65	5.89e-06	13	97	3	27249653
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	RB1CC1 UBN2 CDC42BPB	7.49e-06	14	97	3	28263302
Pubmed	A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.	NSD2 NSD1 MSH6	7.49e-06	14	97	3	26912663
Pubmed	The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.	KALRN HTT	7.70e-06	2	97	2	29789657
Pubmed	Role of EphB3 Receptor in Mediating Head and Neck Tumor Growth, Cell Migration, and Response to PI3K Inhibitor.	EPHB3 PIK3CA	7.70e-06	2	97	2	29970482
Pubmed	NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis.	NSD2 NSD1	7.70e-06	2	97	2	29176703
Pubmed	Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.	KALRN HTT	7.70e-06	2	97	2	9285789
Pubmed	Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.	SP140L SP140	7.70e-06	2	97	2	36130593
Pubmed	Pyruvate dehydrogenase E1 alpha subunit genes in the mouse: mapping and comparison with human homologs.	PDHA1 PDHA2	7.70e-06	2	97	2	2122529
Pubmed	Isolation and characterisation of the mouse pyruvate dehydrogenase E1 alpha genes.	PDHA1 PDHA2	7.70e-06	2	97	2	1581363
Pubmed	Pyruvate dehydrogenase complex: mRNA and protein expression patterns of E1α subunit genes in human spermatogenesis.	PDHA1 PDHA2	7.70e-06	2	97	2	22750801
Pubmed	Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.	ZNF585A ZNF585B	7.70e-06	2	97	2	37668106
Pubmed	The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors.	FLT3 PDGFRB	7.70e-06	2	97	2	17229632
Pubmed	ZBTB38, a novel regulator of autophagy initiation targeted by RB1CC1/FIP200 in spinal cord injury.	ZBTB38 RB1CC1	7.70e-06	2	97	2	30075197
Pubmed	The expression pattern of the pyruvate dehydrogenase E1 alpha subunit genes during spermatogenesis in adult mouse.	PDHA1 PDHA2	7.70e-06	2	97	2	1735460
Pubmed	Adhesion of ZAP-70+ chronic lymphocytic leukemia cells to stromal cells is enhanced by cytokines and blocked by inhibitors of the PI3-kinase pathway.	ZAP70 PIK3CA	7.70e-06	2	97	2	23981382
Pubmed	Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.	SP140L SP140	7.70e-06	2	97	2	35952671
Pubmed	The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice.	SP140L SP140	7.70e-06	2	97	2	34156030
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	NSD2 MAZ SMC6 NSD1 UBN2 RLF MSH6 ZNF451 ZNF512 KPNA1	7.97e-06	608	97	10	36089195
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIF21A THADA ZNF451 DOCK7 SSH2	1.02e-05	102	97	5	11214970
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF585A ZNF695 ZNF585B ZNF610	1.09e-05	49	97	4	9630514
Pubmed	The NSD family of protein methyltransferases in human cancer.	NSD2 NSD1	2.31e-05	3	97	2	25942451
Pubmed	NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report.	FLT3 NSD1	2.31e-05	3	97	2	25145343
Pubmed	Identification of novel FLT3 kinase inhibitors.	FLT3 PDGFRB	2.31e-05	3	97	2	23567961
Pubmed	Potent co-operation between the NUP98-NSD1 fusion and the FLT3-ITD mutation in acute myeloid leukemia induction.	FLT3 NSD1	2.31e-05	3	97	2	24951466
Pubmed	Smcy transgene does not rescue spermatogenesis in sex-reversed mice.	KDM5D ZFY	2.31e-05	3	97	2	11210179
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5D ZFY	2.31e-05	3	97	2	7544442
Pubmed	The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation.	NSD2 NSD1	2.31e-05	3	97	2	37150325
Pubmed	The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.	NSD2 NSD1	2.31e-05	3	97	2	35532818
Pubmed	NUP98::Nsd1 and FLT3-ITD collaborate to generate acute myeloid leukemia.	FLT3 NSD1	2.31e-05	3	97	2	37147424
Pubmed	Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons.	SP140L SP140	4.60e-05	4	97	2	34151776
Pubmed	Transposition of RhoA to the murine Y chromosome.	KDM5D ZFY	4.60e-05	4	97	2	9598304
Pubmed	Screening for hotspot mutations in PI3K, JAK2, FLT3 and NPM1 in patients with myelodysplastic syndromes.	FLT3 PIK3CA	4.60e-05	4	97	2	21789382
Pubmed	Binding to the platelet-derived growth factor receptor transiently activates the p85alpha-p110alpha phosphoinositide 3-kinase complex in vivo.	PDGFRB PIK3CA	4.60e-05	4	97	2	8702949
Pubmed	Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates.	PDGFRB PIK3CA	4.60e-05	4	97	2	12933652
Pubmed	Alternative modes of binding of proteins with tandem SH2 domains.	PDGFRB ZAP70	4.60e-05	4	97	2	10752619
Pubmed	Cytogenetically cryptic ZMYM2-FLT3 and DIAPH1-PDGFRB gene fusions in myeloid neoplasms with eosinophilia.	FLT3 PDGFRB	4.60e-05	4	97	2	28751768
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	PDHA1 KDM5D	4.60e-05	4	97	2	7951230
Pubmed	Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.	NSD2 NSD1	4.60e-05	4	97	2	34271259
Pubmed	Molecular analysis of an isoYq chromosome in a sterile male mouse.	KDM5D ZFY	4.60e-05	4	97	2	8678984
Pubmed	Association of THADA, FOXP4, GPRC6A/RFX6 genes and 8q24 risk alleles with prostate cancer in Northern Chinese men.	RFX6 THADA	4.60e-05	4	97	2	26537068
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CLSTN1 UBN2 CDC42BPB ZNF610 THADA POP1 SSH2 ZNF512	7.39e-05	493	97	8	15368895
Pubmed	In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.	NSD2 NSD1	7.66e-05	5	97	2	25494638
Pubmed	Analysis of pyruvate dehydrogenase expression in embryonic mouse brain: localization and developmental regulation.	PDHA1 PDHA2	7.66e-05	5	97	2	7510589
Pubmed	Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.	NLRP2 POP1	7.66e-05	5	97	2	17178784
Pubmed	Chromosome mapping and expression of a putative testis-determining gene in mouse.	ZFY GLA	7.66e-05	5	97	2	2563174
Pubmed	Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology.	RHOJ DOCK8	7.66e-05	5	97	2	15304341
Pubmed	Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.	NSD2 NSD1	7.66e-05	5	97	2	39390582
Pubmed	Recombinant expression and evaluation of the lipoyl domains of the dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex.	PDHA1 PDHA2	7.66e-05	5	97	2	7864652
Pubmed	A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation.	NSD2 NSD1	7.66e-05	5	97	2	33135541
Pubmed	The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.	RFPL4AL1 RFPL4A	7.66e-05	5	97	2	11850190
Pubmed	The protein tyrosine kinase family of the human genome.	EPHB3 FLT3 PDGFRB ZAP70	8.82e-05	83	97	4	11114734
Pubmed	Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases.	NSD2 NSD1	1.15e-04	6	97	2	24019522
Pubmed	The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins.	PDGFRB PIK3CA	1.15e-04	6	97	2	15377662
Pubmed	Component co-expression and purification of recombinant human pyruvate dehydrogenase complex from baculovirus infected SF9 cells.	PDHA1 PDHA2	1.15e-04	6	97	2	24534072
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	PDHA1 ZC3H8 UBN2 THADA GLA KDSR GNPAT KPNA1	1.26e-04	533	97	8	25544563
Pubmed	Sex-specific perturbation of complex lipids in response to medium-chain fatty acids in very long-chain acyl-CoA dehydrogenase deficiency.	KDSR GNPAT	1.60e-04	7	97	2	31971349
Pubmed	Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.	ZFY GLA	1.60e-04	7	97	2	9196009
Pubmed	Mouse models for the Wolf-Hirschhorn deletion syndrome.	NSD2 HTT	1.60e-04	7	97	2	11152656
Pubmed	Specific and ubiquitous expression of different Zn finger protein genes in the mouse.	ZNF585A ZNF585B	1.60e-04	7	97	2	3143103
Pubmed	Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β during Human Immunodeficiency Virus-Transactivator of Transcription and Cocaine-Mediated Smooth Muscle Hyperplasia.	PDGFRB PIK3CA	1.60e-04	7	97	2	25569182
Pubmed	The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region.	KDM5D ZFY	1.60e-04	7	97	2	9736773
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	EPHB3 FLT3 PDGFRB	1.93e-04	40	97	3	30898150
Pubmed	Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal.	KDM5D ZFY	2.13e-04	8	97	2	7479793
Pubmed	Common variants in the trichohyalin gene are associated with straight hair in Europeans.	FRAS1 THADA	2.13e-04	8	97	2	19896111
Pubmed	RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.	RFPL4AL1 RFPL4A	2.13e-04	8	97	2	12525704
Pubmed	Atrial natriuretic peptide signaling co-regulates lipid metabolism and ventricular conduction system gene expression in the embryonic heart.	PDHA1 PDHA2	2.13e-04	8	97	2	38235330
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	PDGFRB NSD2 NSD1 ZFY	2.53e-04	109	97	4	33554859
Pubmed	Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.	ZBTB38 POP1	2.74e-04	9	97	2	22210626
Pubmed	Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis.	SP140L SP140	2.74e-04	9	97	2	38029747
Pubmed	PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.	EPHB3 NRXN3	2.74e-04	9	97	2	9707552
Pubmed	Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.	PDHA1 PDHA2 IDH3B GLA	3.00e-04	114	97	4	28245920
Pubmed	Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.	EPHB3 PDGFRB	3.41e-04	10	97	2	16413489
Pubmed	Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis.	USP18 KDM5D	3.41e-04	10	97	2	36646704
Pubmed	Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.	PDGFRB PIK3CA	4.17e-04	11	97	2	16135792
Pubmed	Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function.	IDH3B MGME1 GNPAT	4.97e-04	55	97	3	29111377
Pubmed	The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.	ZAP70 TNFRSF11B	4.99e-04	12	97	2	18799150
Pubmed	The role of Dby mRNA in early development of male mouse zygotes.	KDM5D ZFY	4.99e-04	12	97	2	20543856
Pubmed	Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.	KALRN ASIC2 SYT9 GJB7	5.53e-04	134	97	4	24324551
Pubmed	Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development.	TNFRSF11B PIK3CA	5.89e-04	13	97	2	37704707
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK8 DOCK7	6.85e-04	14	97	2	12432077
Pubmed	Genetic mutations associated with cigarette smoking in pancreatic cancer.	FLT3 MSH6 PIK3CA	7.40e-04	63	97	3	19351817
Pubmed	Huntingtin functions as a scaffold for selective macroautophagy.	RB1CC1 HTT	7.89e-04	15	97	2	25686248
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	KDM5D ZFY	7.89e-04	15	97	2	14762062
Pubmed	Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.	ZAP70 PIK3CA	7.89e-04	15	97	2	20702582
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KCNH8 NSD2 ZC3H8 UBN2 CDC42BPB RLF THADA GTF2H2 ZNF512 VPS13B HTT KPNA1	8.97e-04	1489	97	12	28611215
Pubmed	Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.	FLT3 PDGFRB	9.01e-04	16	97	2	10022833
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MAZ SMC6 UBN2 CDC42BPB CEP78 DOCK7 ZMYM1 ZNF512	9.64e-04	724	97	8	36232890
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	PDHA1 ZFY	1.02e-03	17	97	2	19571810
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FRAS1 ZNF585A KALRN NSD2 NSD1 ELP6 LYST CDC42BPB THADA HTT	1.04e-03	1105	97	10	35748872
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	FLT3 MSH6 PIK3CA	1.05e-03	71	97	3	28319113
Pubmed	Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.	FRAS1 ZNF512	1.14e-03	18	97	2	20602751
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM5D ZFY	1.14e-03	18	97	2	12023983
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KALRN ZNRD2 KIF21A NSD1 UBN2 CDC42BPB DOCK7 SSH2 KPNA1	1.50e-03	963	97	9	28671696
Pubmed	New gene functions in megakaryopoiesis and platelet formation.	KALRN DOCK8 THADA	1.53e-03	81	97	3	22139419
Pubmed	Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality.	CYP27A1 TNFRSF11B	1.56e-03	21	97	2	23895994
Pubmed	Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells.	PDGFRB PIK3CA	1.56e-03	21	97	2	21593423
Pubmed	BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	RB1CC1 PIK3CA	1.56e-03	21	97	2	20301425
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	FLT3 NLRP2 MSH6 SP140L HTT	1.88e-03	313	97	5	20800603
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZC3H8 KDM5D ZC3H6 MSH6 ZNF610 GTF2H2 ZNF451 ZNF512	1.93e-03	808	97	8	20412781
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB38 ZNF585A ZNF695 MAZ ZFY ZNF585B RLF ZNF610 ZNF451 ZNF540 ZNF81 ZNF512	2.79e-05	718	73	12	28
GeneFamily	PHD finger proteins	NSD2 NSD1 KDM5D SP140L SP140	3.14e-05	90	73	5	88
GeneFamily	PWWP domain containing	NSD2 NSD1 MSH6	9.20e-05	22	73	3	1147
Coexpression	GSE20727_CTRL_VS_H2O2_TREATED_DC_DN	SMC6 ZC3H6 LYST CDC42BPB ZNF610 THADA SSH2	8.55e-06	196	97	7	M9243
ToppCell	PCW_07-8.5-Epithelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FRAS1 KCNH8 KIF21A RFX6 ANOS1 NRXN3 P3H2	2.30e-07	194	97	7	f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_mem-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KCNH8 SMC6 KDM5D AK8 ZFY SP140	1.91e-06	169	97	6	e3ec9468141b6456398dca17dd8eeaabd2462710
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 KIF21A CLSTN1 PTGFR FCGBP P3H2	3.43e-06	187	97	6	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 KIF21A CLSTN1 PTGFR FCGBP P3H2	3.76e-06	190	97	6	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KCNH8 KIF21A RFX6 NRXN3 SLFN13 P3H2	4.00e-06	192	97	6	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB3 DRP2 LRRC9 POP1 HTT	7.42e-06	123	97	5	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP18 BTBD8 CLSTN1 NRXN3 GLA	2.20e-05	154	97	5	2d98bb7a784fc3215e0d4a1670d662e5df4716c3
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP18 BTBD8 CLSTN1 NRXN3 GLA	2.20e-05	154	97	5	0dec222101530f1727184dbb7c03969d3884f111
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 EFCAB6 KALRN RFX6 MUC6	2.57e-05	159	97	5	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 EFCAB6 KALRN RFX6 MUC6	2.57e-05	159	97	5	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	normal-na-Lymphocytic_NK-NK_bright-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	TMEM241 KIF21A KDM5D CEP78 SLFN13	2.98e-05	164	97	5	b5a91f2cbfad9a2bc38aea576085a37865df955d
ToppCell	LV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	KALRN PDGFRB DOCK8 TTLL7 P3H2	3.06e-05	165	97	5	f37fd95adc95d7753cf6e55ae819976513c7ec77
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 EFCAB6 KALRN RFX6 MUC6	3.15e-05	166	97	5	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	droplet-Thymus-nan-3m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 ANKUB1 CAPG CDC42BPB SP140	3.15e-05	166	97	5	c0af93db981dfd448abc7efcd257f3e5ff066aae
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 EFCAB6 KALRN RFX6 MUC6	3.15e-05	166	97	5	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	KALRN PDGFRB DOCK8 TTLL7 P3H2	3.63e-05	171	97	5	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDGFRB KIF21A ZAP70 CEP78 SLFN13	3.74e-05	172	97	5	86f52f486d67217fc1b8443ab362c975df2974a4
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDGFRB KIF21A ZAP70 CEP78 SLFN13	3.74e-05	172	97	5	fb2df8fea6df5947165f13978f1d1006d15b60fd
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDGFRB KIF21A ZAP70 CEP78 SLFN13	3.74e-05	172	97	5	e38ebb216e4ddcd008148fcbaf709b4f3c83706a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 KIF21A LRRC9 NRXN3 CEP78	3.84e-05	173	97	5	0bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	KALRN NSD1 LYST ZMYM1 HTT	4.17e-05	176	97	5	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	KALRN NSD1 LYST ZMYM1 HTT	4.28e-05	177	97	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	COVID-19-kidney-NK\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LYST ZAP70 CEP78 SLFN13 SP140	4.76e-05	181	97	5	8906ee8a7a1616dfe8c3b5c73988416641213629
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	KALRN PDGFRB TNFRSF11B TTLL7 P3H2	5.02e-05	183	97	5	818fd886e0188091310825f9145fa53328f2c979
ToppCell	IPF-Myeloid-DC_Langerhans\|Myeloid / Disease state, Lineage and Cell class	KALRN KIF21A FCGBP P3H2 SP140	5.28e-05	185	97	5	ced17f69486591c3cbbdc852a3e82c3f3a4a30d7
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FRAS1 KIF21A SYT9 ANOS1 NRXN3	5.42e-05	186	97	5	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	Endothelial-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	RHOJ KALRN ASIC2 ZNF610 CARD14	5.70e-05	188	97	5	ecb74d67314a43b5805b7f2a7bb9ff6c5a60200a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FRAS1 KCNH8 KIF21A RFX6 P3H2	5.85e-05	189	97	5	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FRAS1 KCNH8 ANOS1 NRXN3 P3H2	5.85e-05	189	97	5	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FRAS1 KCNH8 ANOS1 NRXN3 P3H2	5.99e-05	190	97	5	c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 KIF21A PTGFR FCGBP P3H2	5.99e-05	190	97	5	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	COVID-19-kidney-NK\|kidney / Disease (COVID-19 only), tissue and cell type	LYST ZAP70 CEP78 SLFN13 SP140	5.99e-05	190	97	5	e3ca3c9fb9e27670a5dd128dd6564ff98a57159e
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMH+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB38 KDM5D ZAP70 ZFY CEP78	6.15e-05	191	97	5	b2d0ea24970da09209da9d9dda76e30fbfe22917
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB TTLL7 ANOS1 NRXN3	6.30e-05	192	97	5	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB TTLL7 ANOS1 NRXN3	6.30e-05	192	97	5	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KCNH8 KIF21A RFX6 NRXN3 P3H2	6.30e-05	192	97	5	1aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZFY ZNF585B CEP78 ZNF81 SP140	6.61e-05	194	97	5	6be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZBTB38 PDGFRB KIF21A ZAP70 CEP78	6.78e-05	195	97	5	0b50b5c71a4949f3f8fb9f5c30f9d50f53ca050d
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21A NSD1 RFX6 KDM5D TTLL7	6.78e-05	195	97	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	distal-Hematologic-Platelet/Megakaryocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANKUB1 KIF21A AK8 RFPL4A GJB7	7.11e-05	197	97	5	751ffb8792058384079ebfe94872b3525f1aea84
ToppCell	Healthy_donor-NK\|World / disease group, cell group and cell class (v2)	ZBTB38 PDGFRB ZAP70 CEP78 SLFN13	7.28e-05	198	97	5	4c9c40e91173836ad0df2eba635a4cb3385e80c6
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHB3 FRAS1 KIF21A ANOS1 NRXN3	7.28e-05	198	97	5	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EPHB3 FRAS1 KIF21A ANOS1 NRXN3	7.28e-05	198	97	5	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	Control_saline-Epithelial_alveolar\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHB3 KIF21A ANOS1 NRXN3 P3H2	7.28e-05	198	97	5	532b7ef4ad46fe35ad2c6bdf89f70a17f1a2e2e2
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZAP70 CEP78 SLFN13 ZNF451 VPS13B	7.46e-05	199	97	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EPHB3 FRAS1 KIF21A ANOS1 NRXN3	7.46e-05	199	97	5	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	severe-NK_CD56bright\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FRAS1 CAPG ZAP70 CEP78 SLFN13	7.64e-05	200	97	5	82818ab1796fdd0b8be02b341818897595eed841
ToppCell	severe-NK_CD56bright\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FRAS1 CAPG ZAP70 CEP78 SLFN13	7.64e-05	200	97	5	2e67068b98696c313b815a2f0c98643f892e8bc0
Disease	Sotos syndrome 1 (implicated_via_orthology)	NSD2 NSD1	2.82e-05	3	91	2	DOID:0112103 (implicated_via_orthology)
Disease	pyruvate decarboxylase deficiency (implicated_via_orthology)	PDHA1 PDHA2	2.82e-05	3	91	2	DOID:3649 (implicated_via_orthology)
Disease	prostate carcinoma, type 2 diabetes mellitus	ZBTB38 RFX6 THADA ZNF512	3.38e-05	59	91	4	EFO_0001663, MONDO_0005148
Disease	heart septal defect	ASIC2 P3H2	1.40e-04	6	91	2	MONDO_0002078
Disease	lymphocyte count	FRAS1 FLT3 ZBTB38 KALRN ASIC2 NSD1 CLSTN1 LYST TNFRSF11B PRTFDC1 THADA SSH2 HTT SP140	1.53e-04	1464	91	14	EFO_0004587
Disease	postherpetic neuralgia	TMEM241 NRXN3	2.60e-04	8	91	2	MONDO_0041052
Disease	Leigh syndrome	PDHA1 SCN4A	2.60e-04	8	91	2	cv:C0023264
Disease	Crohn's disease	ZBTB38 BTBD8 KALRN THADA NRXN3 DOCK7 SP140	4.37e-04	441	91	7	EFO_0000384
Disease	Mitochondrial disease	PDHA1 SCN4A MGME1	4.72e-04	49	91	3	cv:C0751651
Disease	quality of life during menstruation measurement, dysmenorrheic pain measurement	RB1CC1 VPS13B	5.08e-04	11	91	2	EFO_0007889, EFO_0009366
Disease	neutrophil percentage of leukocytes	FLT3 ZBTB38 KALRN DOCK8 RFX6 THADA GJB7 HTT	6.01e-04	610	91	8	EFO_0007990
Disease	facial morphology measurement	EPHB3 ZNF585A ASIC2 THADA NRXN3 P3H2 VPS13B	6.06e-04	466	91	7	EFO_0007841
Disease	serum non-albumin protein measurement	FLT3 ZBTB38 CDC42BPB ZAP70 SP140L SP140	8.95e-04	361	91	6	EFO_0004568
Disease	platelet storage pool deficiency (implicated_via_orthology)	LYST DOCK7	9.62e-04	15	91	2	DOID:2223 (implicated_via_orthology)
Disease	syndrome (implicated_via_orthology)	NSD2 NSD1	1.39e-03	18	91	2	DOID:225 (implicated_via_orthology)
Disease	parahippocampal gyrus volume measurement	EPHB3 PTGFR	1.39e-03	18	91	2	EFO_0010318
Disease	prion disease	ZBTB38 POP1	1.55e-03	19	91	2	EFO_0004720
Disease	Malignant neoplasm of breast	KALRN NSD2 SMC6 RB1CC1 MSH6 CLCA2 PIK3CA P3H2 POP1 VPS13B	1.75e-03	1074	91	10	C0006142
Disease	BREAST CANCER	RB1CC1 PIK3CA	1.90e-03	21	91	2	114480
Disease	Infiltrating duct carcinoma of female breast	PDGFRB CDC42BPB	1.90e-03	21	91	2	C3165106
Disease	disease of metabolism (implicated_via_orthology)	PDHA1 PDHA2	1.90e-03	21	91	2	DOID:0014667 (implicated_via_orthology)
Disease	colorectal carcinoma (is_implicated_in)	MSH6 PIK3CA	2.09e-03	22	91	2	DOID:0080199 (is_implicated_in)
Disease	Hereditary Diffuse Gastric Cancer	PDHA1 IDH3B FCGBP PIK3CA MUC6	2.16e-03	293	91	5	C1708349
Disease	Stomach Neoplasms	PDHA1 IDH3B FCGBP PIK3CA MUC6	2.29e-03	297	91	5	C0038356
Disease	Malignant neoplasm of stomach	PDHA1 IDH3B FCGBP PIK3CA MUC6	2.40e-03	300	91	5	C0024623
Disease	monocyte count	FLT3 KALRN PDGFRB DOCK8 POLR3H CLSTN1 LYST PRTFDC1 THADA SSH2 KDSR	2.46e-03	1320	91	11	EFO_0005091
Disease	breast cancer (implicated_via_orthology)	MSH6 PIK3CA	2.69e-03	25	91	2	DOID:1612 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EADNLQCGKLICKYV	ADAM2	536	Q99965
QCGKLICKYVGKFLL	ADAM2	541	Q99965
LLKFDGCYCDSLENL	GLA	166	P06280
YKDVTFQLCKALKGC	CEP78	101	Q5JTW2
DCLYTCKEGLDLQVL	CLSTN1	556	O94985
FYLKANCKVCFVALI	ELP6	41	Q0PNE2
FCDKCDLPIKIYGRI	CBLL2	56	Q8N7E2
ALGLLAEKDSNYCLC	ASIC2	346	Q16515
EDVKRCLLPLCGKFY	NSD1	1601	Q96L73
VLCVLKGGYKFCADL	PRTFDC1	71	Q9NRG1
EDCCVQLLGKGLLVY	RFX6	26	Q8HWS3
EIIKELCLCNGLSYE	LRRC9	11	Q6ZRR7
YEVAKKLCSFCEGLV	RB1CC1	126	Q8TDY2
CLTSCEFLKYILLVK	ANOS1	116	P23352
CPCILEGYKFILAEQ	MUC6	721	Q6W4X9
LLLEAQCVQECGKGY	FRAS1	1026	Q86XX4
LLDCVAEYQGKLCVI	MGME1	236	Q9BQP7
FLKKNSCYTLLEVLC	KDM5D	1076	Q9BY66
KYRLVNVCCGQLLKE	AK8	291	Q96MA6
VLKNLYKLASQCCGV	PTGFR	311	P43088
KEYVCQLCEKPGSLL	NSD2	666	O96028
YQLLLKELLTCCEEG	KALRN	1421	O60229
IDLCKNGDIDYCELK	NRXN3	846	Q9Y4C0
ICALCAKEFKNGYNL	MAZ	191	P56270
GGRDDLLYNVICKKC	EPHB3	366	P54753
KFLCEGLRYPECKLQ	NLRP2	886	Q9NX02
LPLICFLLYKVCKLQ	LRIT3	596	Q3SXY7
KDLEEAVQLKCGYAC	RFPL4A	16	A6NLU0
VCDCKLFLYDLPEGK	CDC42BPB	1121	Q9Y5S2
EYVKALECAKAYLLC	P3H2	321	Q8IVL5
GCVFYLKKCLIDQEL	MSH6	686	P52701
VKLAKAIGAQCYLEC	RHOJ	161	Q9H4E5
LCVLEYQGKYILKVC	PIK3CA	241	P42336
DLSYYCCLELKGKEE	POP1	246	Q99575
AIKGFLVKCCAYNSL	FLT3	506	P36888
IGKCVEEILGYLKSC	HTT	1286	P42858
QCCEEVAELYPKIKF	IDH3B	231	O43837
EQELCQEKIACFLGY	GRID2IP	456	A4D2P6
CLLQGFKKCLAEYLS	CARD14	846	Q9BXL6
DLLYLCVSCFEYKGK	DOCK7	1361	Q96N67
LFICVLCFEYKGKQS	DOCK8	1331	Q8NF50
NTLKDFEEGCYLLCK	GNPAT	531	O15228
YCDFIQSCVLLLKAK	EFCAB6	1381	Q5THR3
CVYDLCAQKGDKAFL	FCGBP	5076	Q9Y6R7
ELGEDLLKLYVKPCC	BTBD8	191	Q5XKL5
AICYILFEKRIGCLQ	CYP27A1	216	Q02318
IVGFYILKTLLEGCC	LYST	1871	Q99698
LVLKCFIKCCLQKYL	GJB7	201	Q6PEY0
DCFVLDNGLCGKIYI	CAPG	281	P40121
ELYGYLCVIKVKAFC	SLFN13	306	Q68D06
KCIAIECYKQGAFIT	KDSR	46	Q06136
ACLCGTEVKEKLQYL	DRP2	501	Q13474
NVLICEGKLVKICDF	PDGFRB	831	P09619
ALACKYKGNDEICLT	PDHA2	176	P29803
CGKLNFILKYDCDLE	SYT9	221	Q86SS6
AKYCELPVECKICGL	GTF2H2C;	296	Q6P1K8
KDLEEAVQLKCGYAC	RFPL4AL1	16	F8VTS6
LIFVKYLCKHLFCLL	THADA	1841	Q6YHU6
LFGKSYKECVCKIAL	SCN4A	721	P35499
IKYLVELGCIKPLCD	KPNA1	416	P52294
KLCGRYLVKEIEKLC	INSL6	31	Q9Y581
LVFLISCVLYDCRGK	SMIM36	26	A0A1B0GVT2
CDAKCYKLPLFIAFI	SLCO6A1	571	Q86UG4
RGCLKKAYDLFCGLQ	SLC5A4	596	Q9NY91
NKVVYNVGLCICLFD	POLR3H	36	Q9Y535
EEQLKCEFLLLKVYC	SP140L	471	Q9H930
LKAFVNYSVLCLECK	ANKUB1	256	A6NFN9
CIISKLFKEGCTFIY	CLCA2	216	Q9UQC9
KCNECDKVFGRKLYL	ZNF610	401	Q8N9Z0
NEIKIKYFCGLCDLI	ZNF451	661	Q9Y4E5
LKADGLIYCLKEACP	ZAP70	241	P43403
ECKEGRYLEIEFCLK	TNFRSF11B	106	O00300
CKECGKVFQLIFYFK	ZNF540	301	Q8NDQ6
TLLCNLVEIKLGCYE	UBN2	611	Q6ZU65
QICKYFLEGRCIKGD	ZC3H6	276	P61129
CEECGKVFKLLSYLT	ZNF695	326	Q8IW36
LYKQKIIRGFCHLCD	PDHA1	81	P08559
LQYKFFCLLCKRECI	RLF	551	Q13129
AKLGYLDLCKDCLPE	SSH2	1261	Q76I76
AKYCELPVECKICGL	GTF2H2	296	Q13888
IQCIEKLIEGCFEGY	KIF21A	66	Q7Z4S6
KLYVCIECGRAFVQK	ZNF585B	156	Q52M93
LAIESCLKGLLQAYC	SMC6	521	Q96SB8
VLAGEKLYVCIECGK	ZNF585A	151	Q6P3V2
KLYVCIECGKAFVQK	ZNF585A	156	Q6P3V2
CGTILLQDKQRKIYC	ZNRD2	56	O60232
EVIICGYQKCFQKEK	TMEM241	106	Q24JQ0
EYKEKCFIKLCITLN	VPS13B	3496	Q7Z7G8
KNYIVNKCGLEFKFC	ZBED9	951	Q6R2W3
LKCEFLLLKVYCCSE	SP140	761	Q13342
LELAYCLQKCNVPLF	USP18	121	Q9UMW8
LQNLKLCFSEFDYCK	ZMYM1	976	Q5SVZ6
LGLKEFVCQYCNKAF	ZBTB38	1061	Q8NAP3
KILRENYLFVCSCPK	SMYD5	366	Q6GMV2
LEEKLTCAICLGLYQ	TRIM65	6	Q6PJ69
TLGNFVAGKYKCLLC	ZNF512	431	Q96ME7
VAGKYKCLLCQKEFV	ZNF512	436	Q96ME7
VELCKQCLLVVYKYA	TTLL7	816	Q6ZT98
DEKLYICTKCGKAFI	ZNF81	326	P51508
KCKFCEYETAEQGLL	ZFY	516	P08048
ICKYFLERKCIKGDQ	ZC3H8	196	Q8N5P1
VKALTYCDLQCIILK	KCNH8	631	Q96L42
YCDLQCIILKGLFEV	KCNH8	636	Q96L42