Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

FGD1 FGD6 FGD3 FARP2

3.30e-04231294GO:0005085
GeneOntologyMolecularFunctionmonoatomic ion-gated channel activity

ANO10 KCNT2

9.23e-0431292GO:0022839
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1F ANO10 KCNT2 SLC4A11

1.45e-03343294GO:0005261
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP9B ANO10

2.48e-0351292GO:0140303
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1F ANO10 KCNT2 SLC4A11

4.15e-03459294GO:0005216
GeneOntologyMolecularFunctionGTPase regulator activity

FGD1 FGD6 FGD3 FARP2

5.90e-03507294GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

FGD1 FGD6 FGD3 FARP2

5.90e-03507294GO:0060589
GeneOntologyMolecularFunctionchannel activity

CACNA1F ANO10 KCNT2 SLC4A11

6.66e-03525294GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1F ANO10 KCNT2 SLC4A11

6.70e-03526294GO:0022803
GeneOntologyBiologicalProcessplasma membrane bounded cell projection assembly

FGD1 PLD1 FGD6 KIF24 PLXNB3 CFAP221 FGD3

3.09e-05670297GO:0120031
GeneOntologyBiologicalProcesscell projection assembly

FGD1 PLD1 FGD6 KIF24 PLXNB3 CFAP221 FGD3

3.56e-05685297GO:0030031
GeneOntologyBiologicalProcessregulation of cell morphogenesis

FGD1 PDZD8 FGD6 PLXNB3 FGD3

5.79e-05302295GO:0022604
GeneOntologyBiologicalProcessregulation of cell shape

FGD1 FGD6 PLXNB3 FGD3

6.95e-05159294GO:0008360
GeneOntologyBiologicalProcessfilopodium assembly

FGD1 FGD6 FGD3

1.77e-0478293GO:0046847
GeneOntologyCellularComponentlamellipodium

FGD1 PLD1 FGD6 FGD3

2.73e-04230294GO:0030027
DomainRhoGEF

FGD1 FGD6 FGD3 FARP2

3.56e-0668294SM00325
DomainDH_2

FGD1 FGD6 FGD3 FARP2

4.00e-0670294PS50010
DomainRhoGEF

FGD1 FGD6 FGD3 FARP2

4.00e-0670294PF00621
DomainDH-domain

FGD1 FGD6 FGD3 FARP2

4.24e-0671294IPR000219
Domain-

FGD1 FGD6 FGD3 FARP2

4.24e-06712941.20.900.10
DomainFYVE

FGD1 FGD6 FGD3

1.20e-0529293PF01363
DomainFYVE

FGD1 FGD6 FGD3

1.20e-0529293SM00064
DomainZnf_FYVE-rel

FGD1 FGD6 FGD3

1.95e-0534293IPR017455
DomainPH

FGD1 PLD1 FGD6 FGD3 FARP2

2.48e-05229295PF00169
DomainZnf_FYVE

FGD1 FGD6 FGD3

2.74e-0538293IPR000306
DomainZF_FYVE

FGD1 FGD6 FGD3

3.20e-0540293PS50178
DomainPH

FGD1 PLD1 FGD6 FGD3 FARP2

6.25e-05278295SM00233
DomainPH_DOMAIN

FGD1 PLD1 FGD6 FGD3 FARP2

6.35e-05279295PS50003
DomainPH_domain

FGD1 PLD1 FGD6 FGD3 FARP2

6.46e-05280295IPR001849
Domain-

FGD1 PLD1 FGD6 FGD3 FARP2

3.08e-043912952.30.29.30
DomainPH_dom-like

FGD1 PLD1 FGD6 FGD3 FARP2

4.56e-04426295IPR011993
DomainZnf_FYVE_PHD

FGD1 FGD6 FGD3

1.50e-03147293IPR011011
DomainGDS_CDC24_CS

FGD1 FARP2

1.66e-0339292IPR001331
DomainDH_1

FGD1 FARP2

4.29e-0363292PS00741
Pubmed

Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1.

FGD1 FGD3

4.02e-06429218363964
Pubmed

Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue.

FGD1 FGD3

4.02e-06429210721717
Pubmed

Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.

FGD1 FGD3

4.02e-06429217564959
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

FGD1 ATP9B DPY19L3 PLD1 GTPBP8 FGD6

2.42e-0571929635337019
Pubmed

Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

FGD1 FGD3

4.63e-043829211756498
Pubmed

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

FGD1 FGD3

5.93e-044329212376548
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

FGD1 FGD6 FGD3 FARP2

9.25e-0766214722
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

FGD1 PLD1 FGD6 FGD3 FARP2

3.21e-06206215682
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

FGD1 FGD6 FGD3

5.94e-063121381
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CACNA1F HEATR5A SLC4A11 FGD3

8.09e-06199294d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

CACNA1F KCNT2 FGD6

1.13e-04145293cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

CACNA1F KCNT2 FGD6

1.13e-0414529380684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ST3GAL6 TOPAZ1 SLC4A11

1.37e-0415529390e629681a72baacc7981b82883866a487638dbc
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1F ST3GAL6 SLC4A11

1.65e-04165293d8b0a9b6f704b98e8f0412c11739879a26c036e2
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CACNA1F HEATR5A FGD3

1.68e-04166293417cfb207da08fa1a0fd5f2a13c8786628667a8e
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CACNA1F HEATR5A FGD3

1.68e-04166293063d68f2ffb40770cb4601fa1cb6426ae26f7a37
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CACNA1F HEATR5A FGD3

1.68e-04166293f28d07715e6b00ca2a0df39273c5f569744be5a8
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1F ST3GAL6 SLC4A11

1.71e-041672938b223333c0c7a85b5a1af6f2f5b12ee0d94357f6
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DPY19L3 SETX PLD1

1.90e-041732934968712af1cca8c932abd3323631d7dcaffd4a66
ToppCellASK452-Immune-B_cell|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

HENMT1 ATP9B FARP2

1.93e-0417429369723f5666abc3af5f0431901a60246c9915ef81
ToppCell367C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PLD1 ANO10 MRPL15

2.10e-041792935aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KCNT2 ST3GAL6 SLC4A11

2.24e-041832937c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCNT2 ST3GAL6 SLC4A11

2.24e-04183293848fc6dd129150897ee339343e83c645b6e779eb
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PLD1 ST3GAL6 NTS

2.46e-041892930d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCelldroplet-Heart-HEART-1m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF24 SLC4A11 NTS

2.54e-041912934bfdf44d4402a42530d30c89d94946acdda4321b
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CACNA1F HEATR5A SLC4A11

2.82e-04198293b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CACNA1F HEATR5A FGD3

2.90e-04200293ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Epithelial|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MRPL15 SLC4A11 NTS

2.90e-04200293f611335436bb74d22496f7872dff2110c3d3061f
ToppCellNeuronal-Excitatory-eG(DAPK2)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLD1 KCNT2 FGD6

2.90e-042002937cea58e2691564e653cc972bf5aaff2df1f2666e
ToppCellNeuronal-Excitatory-eG(DAPK2)|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLD1 KCNT2 FGD6

2.90e-042002938444ae3c10b1152dec67ca812e6c417cc3b9cf89
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DPY19L3 ANO10 ST3GAL6

2.90e-042002930eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellNeuronal-Excitatory-eG(DAPK2)--|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLD1 KCNT2 FGD6

2.90e-04200293193c42c31a366a60d80c4c1fc6a1592a5b01a3ad
ToppCellNeuronal-Excitatory-eG(DAPK2)---|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLD1 KCNT2 FGD6

2.90e-042002937c780e995a5fc3793080da61b6bf7a12880e9df8
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CACNA1F HEATR5A SLC4A11

2.90e-042002938683445ad5b70748c4a1f12eb77d47623085147e
ToppCellNeuronal-Excitatory-eG(DAPK2)----L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLD1 KCNT2 FGD6

2.90e-04200293d0b31dc5eedc0635c0d7ceabaa6202386cf2a4a4
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

CACNA1F HEATR5A SLC4A11

2.90e-042002932dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MRPL15 SLC4A11 NTS

2.90e-0420029383afe771e9041c98703d8bad928a98cde601b704
Drug4-nitropyridine

NTS FARP2

9.38e-064292CID000070734
DiseaseCharcot-Marie-Tooth disease type 4H (implicated_via_orthology)

FGD1 FGD3

4.83e-064272DOID:0110192 (implicated_via_orthology)
DiseaseX-linked Aarskog syndrome (implicated_via_orthology)

FGD1 FGD3

4.83e-064272DOID:6683 (implicated_via_orthology)
DiseaseCharcot-Marie-Tooth disease (implicated_via_orthology)

FGD1 FGD3

2.20e-0424272DOID:10595 (implicated_via_orthology)
Diseasechronic lymphocytic leukemia

MRPL15 FARP2

5.30e-03119272EFO_0000095
Diseasemelanoma

PIGU FARP2

5.92e-03126272EFO_0000756

Protein segments in the cluster

PeptideGeneStartEntry
YLRDPNLQKRYPLAL

ACOT8

161

O14734
SILYRVLPIQKYLEP

DPY19L3

141

Q6ZPD9
SQYYPKLRVDIRPQL

HP1BP3

286

Q5SSJ5
PSYKRQLRIYLVSLP

ANO10

306

Q9NW15
VEYALKAQPLRRYIP

CACNA1F

1161

O60840
NYLRAEILYRLKIPP

NEIL1

176

Q96FI4
PLYVLKYLRRKLSPP

ATP9B

1126

O43861
PVNKLLYAREIPRYK

PLXNB3

1806

Q9ULL4
LLILPLPFLLKRFQY

OR51G1

156

Q8NGK1
RYIKPVPGLLLREYL

PDZD8

46

Q8NEN9
LKYQPLKRSLRQYRP

KIF24

781

Q5T7B8
PVQRVPRYELLLKDY

FGD3

296

Q5JSP0
PRYELLLKDYLKRLP

FGD3

301

Q5JSP0
IVPLRAYYRPKKELN

KCNT2

736

Q6UVM3
AYYRPKKELNPIVLL

KCNT2

741

Q6UVM3
VLRLPKQQLRKLLYP

GTPBP8

36

Q8N3Z3
QYPIIYDIRARPRKI

PHB2

76

Q99623
VPGLLYLLQRQYIPV

PIGU

201

Q9H490
YILKRQLYENKPRRP

NTS

146

P30990
QLYENKPRRPYILKR

NTS

151

P30990
VPLQRLLAYPKLNRL

HENMT1

341

Q5T8I9
VYRQRLYELLILLPP

HEATR5A

666

Q86XA9
YLPLNTFLLKPIQRL

FARP2

671

O94887
LQVPQLYKIKRYQPF

CFAP221

576

Q4G0U5
PIRYILLPRIIEAKY

SLC4A11

851

Q8NBS3
RQYKPLSLNRLQYLI

MRPL15

91

Q9P015
ENQKYRVYVVIPLLP

PLD1

811

Q13393
PVQRIPRYELLLKDY

FGD1

516

P98174
YKPYQIRILDPFIIR

ST3GAL6

221

Q9Y274
RVPLLEILKYPYLLL

SETX

111

Q7Z333
YLLKPVQRIPQYRLL

FGD6

1011

Q6ZV73
YPPLEGNLYRKLLLI

TOPAZ1

1566

Q8N9V7