Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	3.57e-12	37	88	8	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	4.51e-12	38	88	8	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.13e-07	11	88	4	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	3.41e-07	14	88	4	GO:0003964
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 TENT4B ERVK-8 ERVK-7 ERVK-10	6.63e-07	38	88	5	GO:0034061
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.99e-06	21	88	4	GO:0035613
GeneOntologyMolecularFunction	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	ALG10 ALG10B	1.92e-05	2	88	2	GO:0106073
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10	2.08e-05	37	88	4	GO:0016891
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10	4.99e-05	46	88	4	GO:0016893
GeneOntologyMolecularFunction	group III metabotropic glutamate receptor activity	GRM4 GRM7	1.15e-04	4	88	2	GO:0001642
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 TMPRSS11E ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	1.16e-04	430	88	9	GO:0004175
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 DIS3L2 ERVK-8 ERVK-7 ERVK-10	3.39e-04	136	88	5	GO:0004540
GeneOntologyMolecularFunction	polysaccharide binding	CLEC18A CLEC18B CLEC18C	3.40e-04	31	88	3	GO:0030247
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	4.11e-04	79	88	4	GO:0004521
GeneOntologyMolecularFunction	structural molecule activity	MRPS31 MPP2 ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 MRPL9	5.24e-04	891	88	12	GO:0005198
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 MARCHF8 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 ZZEF1 MARCHF1	5.24e-04	891	88	12	GO:0008270
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 TENT4B ERVK-8 ERVK-7 ERVK-10	5.64e-04	152	88	5	GO:0016779
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 TMPRSS11E ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 MINDY1	6.01e-04	654	88	10	GO:0008233
GeneOntologyMolecularFunction	transition metal ion binding	ADCY10 ERVK-6 MARCHF8 FA2H ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 ZZEF1 MARCHF1	6.70e-04	1189	88	14	GO:0046914
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM4 GRM7	6.78e-04	9	88	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM4 GRM7	6.78e-04	9	88	2	GO:0001640
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 TENT4B ERVK-8 ERVK-7 ERVK-10 PIF1	1.06e-03	262	88	6	GO:0140097
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH12 DNAH2	2.81e-03	18	88	2	GO:0008569
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	ERVK-6 DIS3L2 ARSF CES5A ERVK-8 ERVK-7 PLD1 ERVK-10 INPP5F UBASH3B	2.88e-03	807	88	10	GO:0016788
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	3.09e-03	136	88	4	GO:0004519
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 DIS3L2 ERVK-8 ERVK-7 ERVK-10	3.57e-03	231	88	5	GO:0004518
GeneOntologyMolecularFunction	glucosyltransferase activity	ALG10 ALG10B	4.19e-03	22	88	2	GO:0046527
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7 ERVK-10	2.05e-07	13	87	4	GO:0015074
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 TENT4B ERVK-8 ERVK-7 ERVK-10 PIF1	1.38e-06	83	87	6	GO:0006278
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9 ERVPABLB-1	1.58e-06	85	87	6	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9 ERVPABLB-1	1.58e-06	85	87	6	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9 ERVPABLB-1	2.08e-06	89	87	6	GO:0006949
GeneOntologyBiologicalProcess	viral process	TYRO3 ERVK-6 TMPRSS11E ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	3.99e-06	464	87	11	GO:0016032
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7 ERVK-10	4.99e-05	48	87	4	GO:0000731
GeneOntologyBiologicalProcess	phosphatidylserine metabolic process	SERINC1 SLC27A1 OSBPL5	1.56e-04	25	87	3	GO:0006658
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ADCY10 GHRHR VIPR1 PRMT5 GRM4 GRM7 CNR1	2.08e-04	286	87	7	GO:0007188
GeneOntologyBiologicalProcess	synaptic transmission, glutamatergic	ALS2 GRM4 ZZEF1 GRM7 CNR1	2.42e-04	132	87	5	GO:0035249
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	GHRHR TYRO3 CLGN LMF2 WFS1 SERINC1 MARCHF8 FA2H PIGS SLC27A1 ALG10 OSBPL5 PEX16 PDIA5 LSS PLD1 MARCHF1 ALG10B	1.01e-05	1327	89	18	GO:0042175
GeneOntologyCellularComponent	endoplasmic reticulum membrane	TYRO3 CLGN LMF2 WFS1 SERINC1 MARCHF8 FA2H PIGS SLC27A1 ALG10 OSBPL5 PEX16 PDIA5 LSS PLD1 MARCHF1 ALG10B	2.78e-05	1293	89	17	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	TYRO3 CLGN LMF2 WFS1 SERINC1 MARCHF8 FA2H PIGS SLC27A1 ALG10 OSBPL5 PEX16 PDIA5 LSS PLD1 MARCHF1 ALG10B	2.94e-05	1299	89	17	GO:0098827
GeneOntologyCellularComponent	presynaptic active zone	TENM3 FZD3 GRM4 ZZEF1 GRM7	3.43e-04	141	89	5	GO:0048786
GeneOntologyCellularComponent	presynaptic active zone membrane	TENM3 FZD3 GRM4 GRM7	3.44e-04	78	89	4	GO:0048787
GeneOntologyCellularComponent	inner dynein arm	DNAH12 DNAH2	7.89e-04	10	89	2	GO:0036156
GeneOntologyCellularComponent	presynaptic membrane	SLC6A11 TENM3 FZD3 GRM4 GRM7 CNR1	1.19e-03	277	89	6	GO:0042734
GeneOntologyCellularComponent	axon	ADCY10 CNTNAP3B TENM3 FZD3 SNX18 CNTNAP3 ALS2 INPP5F GRM4 GRM7 CNR1	1.39e-03	891	89	11	GO:0030424
MousePheno	abnormal motor learning	CNTNAP3B FA2H CNTNAP3 ALS2 GRM4	3.97e-06	60	56	5	MP:0002804
MousePheno	increased sperm motility	WFS1 CNR1	1.58e-05	2	56	2	MP:0031426
Domain	Alg10	ALG10 ALG10B	1.68e-05	2	77	2	IPR016900
Domain	DIE2_ALG10	ALG10 ALG10B	1.68e-05	2	77	2	PF04922
Domain	-	CLEC18A CLEC18B CLEC18C	2.96e-05	15	77	3	3.40.33.10
Domain	CAP	CLEC18A CLEC18B CLEC18C	2.96e-05	15	77	3	PF00188
Domain	CAP_domain	CLEC18A CLEC18B CLEC18C	2.96e-05	15	77	3	IPR014044
Domain	SCP	CLEC18A CLEC18B CLEC18C	2.96e-05	15	77	3	SM00198
Domain	Allrgn_V5/Tpx1	CLEC18A CLEC18B CLEC18C	2.96e-05	15	77	3	IPR001283
Domain	GPCR_2_VIP_rcpt_1	GHRHR VIPR1	5.02e-05	3	77	2	IPR001771
Domain	EGF_3	CNTNAP3B CLEC18A CLEC18B TENM3 CNTNAP3 CLEC18C	4.19e-04	235	77	6	PS50026
Domain	EGF	CNTNAP3B CLEC18A CLEC18B TENM3 CNTNAP3 CLEC18C	4.19e-04	235	77	6	SM00181
Domain	MARCH-like	MARCHF8 MARCHF1	4.62e-04	8	77	2	IPR033275
Domain	GPCR_3_mtglu_rcpt	GRM4 GRM7	4.62e-04	8	77	2	IPR000162
Domain	EGF-like_dom	CNTNAP3B CLEC18A CLEC18B TENM3 CNTNAP3 CLEC18C	5.69e-04	249	77	6	IPR000742
Domain	EGF_1	CNTNAP3B CLEC18A CLEC18B TENM3 CNTNAP3 CLEC18C	6.44e-04	255	77	6	PS00022
Domain	C-type_lectin_CS	CLEC18A CLEC18B CLEC18C	7.38e-04	43	77	3	IPR018378
Domain	EGF_2	CNTNAP3B CLEC18A CLEC18B TENM3 CNTNAP3 CLEC18C	7.87e-04	265	77	6	PS01186
Domain	RINGv	MARCHF8 MARCHF1	9.01e-04	11	77	2	PF12906
Domain	ZF_RING_CH	MARCHF8 MARCHF1	9.01e-04	11	77	2	PS51292
Domain	NCD3G	GRM4 GRM7	1.27e-03	13	77	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM4 GRM7	1.27e-03	13	77	2	IPR011500
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH2	1.48e-03	14	77	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DNAH2	1.48e-03	14	77	2	IPR013602
Domain	DHC_N2	DNAH12 DNAH2	1.48e-03	14	77	2	PF08393
Domain	AAA_8	DNAH12 DNAH2	1.48e-03	14	77	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH2	1.48e-03	14	77	2	IPR011704
Domain	GPCR_3_CS	GRM4 GRM7	1.48e-03	14	77	2	IPR017979
Domain	AAA_5	DNAH12 DNAH2	1.48e-03	14	77	2	PF07728
Domain	DHC_fam	DNAH12 DNAH2	1.70e-03	15	77	2	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH2	1.70e-03	15	77	2	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH2	1.70e-03	15	77	2	PF03028
Domain	GPCR_2_secretin-like	GHRHR VIPR1 FZD3	1.95e-03	60	77	3	IPR000832
Domain	GPCR_2-like	GHRHR VIPR1 FZD3	1.95e-03	60	77	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	GHRHR VIPR1 FZD3	2.04e-03	61	77	3	PS50261
Domain	Znf_RING-CH	MARCHF8 MARCHF1	2.19e-03	17	77	2	IPR011016
Domain	RINGv	MARCHF8 MARCHF1	2.19e-03	17	77	2	SM00744
Domain	Integrin_alpha-2	ITGA11 ITGA7	2.46e-03	18	77	2	IPR013649
Domain	Integrin_alpha2	ITGA11 ITGA7	2.46e-03	18	77	2	PF08441
Domain	Integrin_alpha	ITGA11 ITGA7	2.46e-03	18	77	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGA11 ITGA7	2.46e-03	18	77	2	PS00242
Domain	Int_alpha_beta-p	ITGA11 ITGA7	2.74e-03	19	77	2	IPR013519
Domain	Int_alpha	ITGA11 ITGA7	2.74e-03	19	77	2	SM00191
Domain	FA58C	CNTNAP3B CNTNAP3	3.35e-03	21	77	2	SM00231
Domain	GPCR_3	GRM4 GRM7	3.35e-03	21	77	2	IPR000337
Domain	FA58C_3	CNTNAP3B CNTNAP3	3.35e-03	21	77	2	PS50022
Domain	FA58C_1	CNTNAP3B CNTNAP3	3.35e-03	21	77	2	PS01285
Domain	FA58C_2	CNTNAP3B CNTNAP3	3.35e-03	21	77	2	PS01286
Domain	7tm_3	GRM4 GRM7	3.67e-03	22	77	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GRM4 GRM7	3.67e-03	22	77	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM4 GRM7	3.67e-03	22	77	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM4 GRM7	3.67e-03	22	77	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GRM4 GRM7	3.67e-03	22	77	2	PS50259
Domain	FG_GAP	ITGA11 ITGA7	3.67e-03	22	77	2	PS51470
Domain	GPCR_3_C	GRM4 GRM7	3.67e-03	22	77	2	IPR017978
Domain	zf-CCHC	ERVK-6 ERVK-5	4.01e-03	23	77	2	PF00098
Pathway	WP_GPCRS_NONODORANT	GHRHR VIPR1 FZD3 ACKR3 P2RY10 RXFP4 GRM4 GRM7 CNR1	5.68e-07	266	53	9	MM15843
Pathway	REACTOME_GPCR_LIGAND_BINDING	GHRHR VIPR1 FZD3 ACKR3 P2RY10 RXFP4 GRM4 GRM7 CNR1	5.04e-05	463	53	9	M507
Pathway	REACTOME_GPCR_LIGAND_BINDING	GHRHR VIPR1 ACKR3 P2RY10 RXFP4 GRM4 GRM7 CNR1	1.87e-04	430	53	8	MM15160
Pathway	BIOCARTA_CB1R_PATHWAY	PLD1 CNR1	2.88e-04	7	53	2	MM1569
Pathway	BIOCARTA_CB1R_PATHWAY	PLD1 CNR1	2.88e-04	7	53	2	M22054
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	GHRHR VIPR1 P2RY10 GRM4 GRM7 CNR1	5.24e-04	272	53	6	M13380
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	ZFYVE9 SERINC1 SLC27A1 OSBPL5 SNX18 LSS STAR	5.26e-04	381	53	7	M48063
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST	ALG10 ALG10B	7.46e-04	11	53	2	M47614
Pathway	PID_ARF6_TRAFFICKING_PATHWAY	ITGA11 PLD1 ITGA7	8.18e-04	49	53	3	M67
Pathway	REACTOME_SIGNALING_BY_GPCR	GHRHR VIPR1 FZD3 ACKR3 P2RY10 RXFP4 GRM4 GRM7 CNR1	1.11e-03	702	53	9	M746
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 ERVPABLB-1	5.42e-14	94	89	10	21542922
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9 ERVPABLB-1	2.16e-13	12	89	6	14557543
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	4.01e-11	4	89	4	10469592
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-5 ERVK-19 ERVK-10	4.01e-11	4	89	4	7983737
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-7 ERVK-21	2.00e-10	5	89	4	12629516
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21 ERVPABLB-1	8.31e-09	10	89	4	12970426
Pubmed	Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.	CLEC18A CLEC18B CLEC18C	1.62e-08	3	89	3	26170455
Pubmed	The C-type lectin-like domain superfamily.	CLEC18A CLEC18B CLEC18C	1.62e-08	3	89	3	16336259
Pubmed	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.	CLEC18A CLEC18B CLEC18C	1.62e-08	3	89	3	33603190
Pubmed	The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.	CLEC18A CLEC18B CLEC18C	6.47e-08	4	89	3	16709836
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-10 ERVK-24	1.19e-07	18	89	4	18664271
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-5 ERVK-7	1.61e-07	5	89	3	11401426
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	3.22e-07	6	89	3	15063128
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	NEMP1 ITGA11 CLGN LMF2 MAN2B2 TENM3 WFS1 ACKR3 PRMT5 PIGS CNTNAP3 PDIA5 ITGA7 ZZEF1	2.17e-06	1201	89	14	35696571
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	CLEC18A CLEC18B CLEC18C SVOPL	2.48e-06	37	89	4	22432025
Pubmed	The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.	CNTNAP3B CNTNAP3	6.48e-06	2	89	2	31150793
Pubmed	Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia.	GRM4 GRM7	6.48e-06	2	89	2	19351574
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	6.48e-06	2	89	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	6.48e-06	2	89	2	9460924
Pubmed	Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.	CNTNAP3B CNTNAP3	6.48e-06	2	89	2	26807827
Pubmed	MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.	MARCHF8 MARCHF1	6.48e-06	2	89	2	21757542
Pubmed	Dissociation of heterotrimeric g proteins in cells.	GHRHR VIPR1 ACKR3 P2RY10 RXFP4 CNR1	6.97e-06	179	89	6	18577758
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	GHRHR VIPR1 SLC6A11 PLD1 GRM4 GRM7 CNR1	1.25e-05	300	89	7	19086053
Pubmed	Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection.	MARCHF8 MARCHF1	1.94e-05	3	89	2	27503069
Pubmed	A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).	ALG10 ALG10B	1.94e-05	3	89	2	24303013
Pubmed	Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.	MARCHF8 MARCHF1	1.94e-05	3	89	2	23606747
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	1.94e-05	3	89	2	10516026
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	1.94e-05	3	89	2	9971820
Pubmed	Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain.	MARCHF8 MARCHF1	1.94e-05	3	89	2	38299743
Pubmed	Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.	GRM4 GRM7	1.94e-05	3	89	2	33068816
Pubmed	Ubiquitination by the membrane-associated RING-CH-8 (MARCH-8) ligase controls steady-state cell surface expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor 1.	MARCHF8 MARCHF1	1.94e-05	3	89	2	23300075
Pubmed	Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.	GRM4 GRM7	1.94e-05	3	89	2	9473604
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	CNTNAP3B CNTNAP3 CNR1	2.41e-05	22	89	3	26494785
Pubmed	Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.	MARCHF8 MARCHF1	3.87e-05	4	89	2	27503071
Pubmed	The HLA-DRalpha chain is modified by polyubiquitination.	MARCHF8 MARCHF1	3.87e-05	4	89	2	19117940
Pubmed	The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.	ALG10 ALG10B	3.87e-05	4	89	2	14525949
Pubmed	Distribution of group-III metabotropic glutamate receptors in the retina.	GRM4 GRM7	3.87e-05	4	89	2	17311335
Pubmed	Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.	CNTNAP3B CNTNAP3 CNR1	5.64e-05	29	89	3	31491374
Pubmed	Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.	GRM4 GRM7	9.65e-05	6	89	2	16144832
Pubmed	In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.	CNTNAP3B CNTNAP3	9.65e-05	6	89	2	34143959
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH12 DNAH2	1.35e-04	7	89	2	9256245
Pubmed	Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.	GRM4 GRM7	1.35e-04	7	89	2	9920659
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NEMP1 URB1 CLGN LMF2 WFS1 SERINC1 PIGS DNAH2 LSS MINDY1	1.49e-04	942	89	10	31073040
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	GHRHR VIPR1 ACKR3 P2RY10 CNR1	1.68e-04	200	89	5	18240029
Pubmed	Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.	GRM4 GRM7	2.88e-04	10	89	2	9069281
Pubmed	The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.	GRM4 GRM7	2.88e-04	10	89	2	17156446
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH12 DNAH2	5.78e-04	14	89	2	9373155
Pubmed	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	VIPR1 WFS1 CNR1	6.31e-04	65	89	3	19598235
Pubmed	Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.	MARCHF8 MARCHF1	7.59e-04	16	89	2	14722266
Pubmed	Identification of cAMP analogue inducible genes in RAW264 macrophages.	INPP5F MINDY1	7.59e-04	16	89	2	11004510
Pubmed	Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages.	CNTNAP3B CNTNAP3	8.59e-04	17	89	2	26389685
Pubmed	Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.	ACKR3 RXFP4 CNR1	9.57e-04	75	89	3	2834384
Pubmed	Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.	MARCHF8 MARCHF1	9.65e-04	18	89	2	35411049
Pubmed	The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.	CLGN LMF2 WFS1 PIGS	1.11e-03	176	89	4	28692057
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	RXFP4 GRM4 GRM7	1.11e-03	79	89	3	12679517
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	VIPR1 GRM4 GRM7	1.20e-03	81	89	3	22723691
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	DIS3L2 OSBPL5 PEX16 FAM91A1 PLD1 KLHDC10	1.22e-03	462	89	6	31138677
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	ITGA11 TENM3	1.45e-03	22	89	2	35245678
Pubmed	Functional genetic analysis of mouse chromosome 11.	ALG10 ALG10B	1.58e-03	23	89	2	12955145
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRM4 GRM7	1.72e-03	24	89	2	35746896
Pubmed	PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.	TENT4B PLD1	1.72e-03	24	89	2	24710276
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	GLT6D1 MAN2B2	1.87e-03	25	89	2	2283726
Pubmed	Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation.	FA2H LSS	1.87e-03	25	89	2	32266943
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	GLT6D1 MAN2B2	2.02e-03	26	89	2	8218172
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGA11 ITGA7	2.18e-03	27	89	2	31541017
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	TYRO3 TENM3 FZD3 PRMT5 PLD1	2.30e-03	358	89	5	32460013
Pubmed	Novel genes differentially expressed in cortical regions during late neurogenesis.	TENM3 SVOPL	2.34e-03	28	89	2	17614941
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TENM3 OSBPL5 DNAH2	2.38e-03	103	89	3	10819331
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NEMP1 SERINC1 OSBPL5 INPP5F ZZEF1 MINDY1	2.41e-03	529	89	6	14621295
Interaction	SLC22A9 interactions	CLGN LMF2 SERINC1 SLC27A1 ALG10 ITGA7	8.24e-06	120	80	6	int:SLC22A9
Interaction	APOM interactions	CNTNAP3B CLGN CNTNAP3 ITGA7	2.53e-05	43	80	4	int:APOM
GeneFamily	Alpha-1,2-glucosyltransferases	ALG10 ALG10B	9.77e-06	2	57	2	448
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM4 GRM7	2.70e-04	8	57	2	281
GeneFamily	C-type lectin domain family	CLEC18A CLEC18B CLEC18C	4.37e-04	47	57	3	494
GeneFamily	Ring finger proteins\|Membrane associated ring-CH-type fingers	MARCHF8 MARCHF1	5.27e-04	11	57	2	60
GeneFamily	Dyneins, axonemal	DNAH12 DNAH2	1.29e-03	17	57	2	536
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA11 ITGA7	1.45e-03	18	57	2	1160
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VIPR1 CNTNAP3B ITGA11 TENM3 CNTNAP3 MARCHF1	8.87e-07	180	80	6	e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCell	COVID-19_Mild-Neu_2\|World / 5 Neutrophil clusters in COVID-19 patients	NEMP1 ITGA11 HECTD2 PCNX4 CARNMT1	5.41e-06	140	80	5	b1429028c52f84127b894b93b55961badcd5246f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B GLT6D1 TENM3 CNTNAP3 UBASH3B	1.78e-05	179	80	5	d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLGN ACKR3 TMEM158 PDIA5 SLC52A3	1.88e-05	181	80	5	cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VIPR1 CNTNAP3B ITGA11 TENM3 CNTNAP3	1.93e-05	182	80	5	72e65a23cd36085bc880087d3cae92395de918a1
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VIPR1 CNTNAP3B ITGA11 TENM3 CNTNAP3	1.93e-05	182	80	5	05c167158815bf25d509df59ab386e1990712765
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CNTNAP3B SLC6A11 TENM3 WFS1 CNTNAP3	1.98e-05	183	80	5	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CNTNAP3B SLC6A11 TENM3 WFS1 CNTNAP3	2.14e-05	186	80	5	40070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell	Anterior_Cingulate_gyrus_(CgG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B TENM3 HECTD2 CNTNAP3 CNR1	2.14e-05	186	80	5	32af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MARCHF8 ACKR3 FAM91A1 INPP5F ITGA7	3.03e-05	200	80	5	be46efc899d06c55ee297bee3126f69bcdb2048b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ITGA11 URB1 ZFYVE9 CLEC18B TENM3	3.03e-05	200	80	5	fe772d98c461c973dfc082e1fc50117c27ced804
Disease	Long Qt Syndrome 2	ALG10 ALG10B	2.07e-05	3	78	2	C3150943
Disease	nonsyndromic deafness (implicated_via_orthology)	ALG10 ALG10B	1.03e-04	6	78	2	DOID:0050563 (implicated_via_orthology)
Disease	autosomal recessive intellectual developmental disorder (implicated_via_orthology)	CNTNAP3B CNTNAP3	1.91e-04	8	78	2	DOID:0060308 (implicated_via_orthology)
Disease	gut microbiome measurement, bone density	MPP2 ACKR3 PLD1	1.17e-03	78	78	3	EFO_0003923, EFO_0007874
Disease	alcohol dependence	MPP2 CLGN ALG10 ALG10B	1.43e-03	183	78	4	MONDO_0007079
Disease	Attention Deficit Disorder	GRM7 CNR1	1.54e-03	22	78	2	C0041671
Disease	Minimal Brain Dysfunction	GRM7 CNR1	1.54e-03	22	78	2	C1321905
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM4 CNR1	1.68e-03	23	78	2	C0393672
Disease	Epilepsy, Lateral Temporal	GRM4 CNR1	1.68e-03	23	78	2	C0393682
Disease	Uncinate Epilepsy	GRM4 CNR1	1.68e-03	23	78	2	C0014558
Disease	Epilepsy, Temporal Lobe	GRM4 CNR1	1.68e-03	23	78	2	C0014556
Disease	visual epilepsy (biomarker_via_orthology)	SLC6A11 WFS1 PLD1	1.77e-03	90	78	3	DOID:11832 (biomarker_via_orthology)
Disease	Attention deficit hyperactivity disorder	GRM7 CNR1	1.83e-03	24	78	2	C1263846
Disease	triacylglycerol 52:6 measurement	CACNA2D4 GRM7	1.99e-03	25	78	2	EFO_0010418
Disease	amino acid measurement	MPP2 GHRHR ITGA11 DNAH12 CNTNAP3 CLEC18C GRM7	2.11e-03	678	78	7	EFO_0005134

Protein segments in the cluster

Peptide	Gene	Start	Entry
GKLSGWVSVPWLLIF	ARSF	206	P54793
PSWWQKILIVLATLW	ERVPABLB-1	446	P60509
WAVLKVLLLLPTQTW	CNTNAP3	6	Q9BZ76
LTWLEWEELKIPLHG	C2orf80	61	Q0P641
DTIWKILKPGGIWIN	CARNMT1	326	Q8N4J0
LPSLRTEVWTWGKGK	ALS2	521	Q96Q42
IPIIKLEWGSPWAVL	GRM4	576	Q14833
VLTEPGVWKVGEAIW	LINC00528	141	Q8N1L1
VSVGVVKPAIWIFAW	ALG10B	71	Q5I7T1
WLQTILSLPSWEKIV	ADCY10	1571	Q96PN6
VIWTLTPEGKILDEW	DIS3L2	466	Q8IYB7
VVFGKWENLPLWTLE	TENT4B	181	Q8NDF8
ITAIWETRLKAQPWL	NUDT22	41	Q9BRQ3
LLPIKPVEIAIEAWW	FAM91A1	156	Q658Y4
WWIPSAAKVLALLNT	HECTD2	311	Q5U5R9
GVLPWSVALDWLTEK	PCNX4	1001	Q63HM2
FKIWLVVPSLLELAW	KLHDC10	396	Q6PID8
VLIPKWHDIWTRIQI	NEMP1	71	O14524
ILIWAIWVLAAPTKG	CES5A	11	Q6NT32
AVAIPSWGKFWLAVL	LSS	186	P48449
RKWVVFDGPIDTLWI	DNAH12	1611	Q6ZR08
VKWIPWKGEQTPIIT	MINDY1	116	Q8N5J2
GILEWPFWTKLVVVA	MARCHF8	191	Q5T0T0
EKLRTEPQWVPVSWV	MPP2	561	Q14168
EDWQVPIWIIVGSTL	ITGA11	1136	Q9UKX5
GVLEWPFWTKLVVVA	MARCHF1	191	Q8TCQ1
IVSWVLGFLSEIWPV	OR9A1P	146	Q8NGU1
KTVWYSVPIIWVPLV	FA2H	166	Q7L5A8
IIPLTVWNDWAIIKA	ERVK-10	76	P87889
IIPLTVWNDWAIIKA	ERVK-19	76	Q9YNA8
IIPLTVWNDWAIIKA	ERVK-21	76	P62683
IIPLTVWNDWAIIKA	ERVK-24	76	P63145
IIPLTVWNDWAIIKA	ERVK-5	76	Q9HDB9
IIPLTVWNDWAIIKA	ERVK-6	76	Q7LDI9
IIPLTVWNDWAIIKA	ERVK-7	76	P63130
IIPLTVWNDWAIIKA	ERVK-8	76	P62685
IIPLTVWNDWAIIKA	ERVK-9	76	P63126
IIPLTVWNDWAIIKA	HERVK_113	76	P62684
GWDTVLGTIRFLKPW	CD1E	66	P15812
ITKTDWLAPVLWEGT	GLT6D1	46	Q7Z4J2
AWGQAKIPLETVKLW	CACNA2D4	66	Q7Z3S7
LAIADLWVVLTIPVW	ACKR3	86	P25106
RDWNTLIVGKLSPWI	PRMT5	76	O14744
WTIAIVIAVLPLLGW	CNR1	241	P21554
YWWIIKGPIVLSVGV	GHRHR	281	Q02643
VVHPVLWLLLGSWSL	MAN2B2	816	Q9Y2E5
ILTITWFLAAVPKWG	FZD3	306	Q9NPG1
IIKLEWHSPWAVIPV	GRM7	581	Q14831
VAEGVPWWVILLAVL	ITGA7	1076	Q13683
PWWVILLAVLAGLLV	ITGA7	1081	Q13683
EKWILFDGPVDTLWI	DNAH2	2161	Q9P225
LLDWKVTQEKVPWGI	SLC13A5	396	Q86YT5
VIGKIQLHSDLPWWL	INPP5F	51	Q9Y2H2
WAVLKVLLLLPTQTW	CNTNAP3B	6	Q96NU0
LAIWVVLPSWLSSAK	PDIA5	11	Q14554
GFVIPVIIIAWCTWK	P2RY10	206	O00398
SWTKLWCVLKPGVLL	OSBPL5	141	Q9H0X9
VAIVLGLPLWWKTTE	PIGS	26	Q96S52
RSWKPWLLAGVVDVT	PEX16	241	Q9Y5Y5
LIQWTKEGKLWEFPI	MRPS31	301	Q92665
TLWGVLVKFDLVPWN	RXFP4	266	Q8TDU9
WKRCVPVTLELTKVW	PIF1	366	Q9H611
ILSEWWLKEPIRSTG	AK9	1106	Q5TCS8
SWVTINGLWVELPLL	SLC52A3	16	Q9NQ40
PIWLWKLLVVAGASV	TMEM185B	46	Q9H7F4
LPTVWLGVASLVWEL	LMF2	366	Q9BU23
WWLSPEIFLKRPVVE	PLD1	381	Q13393
LSKILPDLNTVVWVW	URB1	501	O60287
WIGIVLYVWTLVAPL	SERINC1	431	Q9NRX5
LASVIIPTIGWRWLI	SVOPL	191	Q8N434
IIPLTVWNDWAIIKA	ERVK-9	76	P63128
VSIGVIKPAIWIFGW	ALG10	71	Q5BKT4
WLWLIYLVTAGVPIA	CLGN	471	O14967
VLLALLGTAWAEVWP	CLEC18A	16	A5D8T8
VLLALLGTTWAEVWP	CLEC18B	16	Q6UXF7
VLLALLGTAWAEVWP	CLEC18C	16	Q8NCF0
RGTVIVERWWKVPLA	MRPL9	51	Q9BYD2
WEPWVIGLVIFISLI	TMPRSS11E	16	Q9UL52
SSLWWIIKGPILTSI	VIPR1	291	P32241
VTSWPGKQVETLRLW	VEZF1	356	Q14119
LTWWTLAQDVPLGTK	SLC5A10	546	A0PJK1
VVSLALLWLLGLPWT	SLC27A1	11	Q6PCB7
WLLSIDLKGWLPKSI	STAR	241	P49675
LVIVVWSVAALIWPV	TMEM158	231	Q8WZ71
GKAWPLEQVIWSVLC	SNX18	541	Q96RF0
IIILVPCWWHAVIVT	UNQ5815/PRO19632	76	Q6UWF5
PLWICITVWKTEGTL	SLC6A11	566	P48066
ATVQGWWETKLLLPK	TMDD1	261	P0DPE3
AGRWTTPDIEIWKRI	TENM3	2361	Q9P273
HLPLAKIWEWLVGVA	ZZEF1	2821	O43149
LKIRVEPGLFEWTKW	UBASH3B	491	Q8TF42
PEPVTIVWWRGTTKI	TYRO3	166	Q06418
GILIQKWETPWAKVF	ZFYVE9	1056	O95405
VAVCSVPLLLRWWTK	WFS1	601	O76024