Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

SOX1 TSHZ3 TSHZ1 NPAS4 DLX6 PAX9

1.51e-031412196GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

SOX1 NPAS4 DLX6 TET1 PAX9

5.19e-031244195GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

SOX1 NPAS4 DLX6 TET1 PAX9

5.69e-031271195GO:0000987
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

TUBD1 SORBS3

6.69e-03130192GO:0005200
GeneOntologyCellularComponentserine-type peptidase complex

F7 COLEC10

1.99e-0422202GO:1905286
GeneOntologyCellularComponentchromatin

SOX1 TSHZ3 TSHZ1 NPAS4 DLX6 TET1 PAX9

3.00e-041480207GO:0000785
MousePhenoabnormal laryngeal cartilage morphology

TSHZ1 DLX6 PAX9

6.41e-0629183MP:0002256
MousePhenoaerophagia

TSHZ1 DLX6

9.38e-064182MP:0010994
MousePhenoabnormal tympanic ring morphology

TSHZ1 DLX6 PAX9

9.55e-0633183MP:0000030
MousePhenoabnormal larynx morphology

TSHZ1 DLX6 PAX9

1.72e-0540183MP:0002249
MousePhenoabsent mandibular coronoid process

DLX6 PAX9

4.36e-058182MP:0004912
MousePhenoabnormal intervertebral disk morphology

TSHZ1 DLX6 PAX9

8.16e-0567183MP:0004173
MousePhenoabnormal symphysis morphology

TSHZ1 DLX6 PAX9

9.70e-0571183MP:0030877
MousePhenoabnormal gonial bone morphology

TSHZ1 DLX6

1.21e-0413182MP:0008380
MousePhenodecreased tympanic ring size

DLX6 PAX9

1.63e-0415182MP:0006020
MousePhenoabnormal cartilaginous joint morphology

TSHZ1 DLX6 PAX9

1.66e-0485183MP:0030875
MousePhenoabnormal middle ear morphology

TSHZ1 DLX6 PAX9

2.10e-0492183MP:0000049
MousePhenoabnormal thyroid cartilage morphology

DLX6 PAX9

2.37e-0418182MP:0002260
MousePhenoabnormal mandibular coronoid process morphology

DLX6 PAX9

2.37e-0418182MP:0004594
MousePhenoabnormal pterygoid process morphology

DLX6 PAX9

3.24e-0421182MP:0004452
MousePhenoabnormal neurocranium morphology

TSHZ1 DLX6 TET1 PAX9

3.32e-04269184MP:0000074
MousePhenoabnormal mandibular ramus morphology

DLX6 PAX9

3.90e-0423182MP:0010150
MousePhenoanencephaly

DLX6 TET1

4.25e-0424182MP:0001890
MousePhenoabnormal fibrous joint morphology

TSHZ1 DLX6 PAX9

6.46e-04135183MP:0030878
MousePhenoabnormal malleus morphology

TSHZ1 DLX6

8.57e-0434182MP:0000029
MousePhenoabnormal hyoid bone morphology

DLX6 PAX9

9.61e-0436182MP:0003056
MousePhenocraniofacial phenotype

F7 TSHZ1 TDG DLX6 COLEC10 TET1 PAX9

1.04e-031372187MP:0005382
MousePhenoabnormal craniofacial morphology

F7 TSHZ1 TDG DLX6 COLEC10 TET1 PAX9

1.04e-031372187MP:0000428
MousePhenoabnormal zygomatic bone morphology

DLX6 COLEC10

1.25e-0341182MP:0005270
MousePhenoabnormal pharyngeal arch morphology

TDG DLX6 PAX9

1.28e-03171183MP:0002884
MousePhenoabnormal carotid artery morphology

TDG PAX9

1.43e-0344182MP:0004181
MousePhenoabnormal first pharyngeal arch morphology

DLX6 PAX9

1.71e-0348182MP:0006337
MousePhenoabnormal craniofacial development

TSHZ1 TDG DLX6 PAX9

1.84e-03425184MP:0003935
MousePhenoabnormal head morphology

F7 TAOK1 TSHZ1 DLX6 TET1 PAX9

2.09e-031120186MP:0000432
MousePhenorespiratory distress

TSHZ3 TSHZ1 PAX9

2.13e-03204183MP:0001954
MousePhenoheart hemorrhage

F7 TDG

2.23e-0355182MP:0009698
MousePhenoabnormal middle ear ossicle morphology

TSHZ1 DLX6

2.31e-0356182MP:0005105
MousePhenoneonatal lethality

F7 TSHZ3 TSHZ1 DLX6 PAX9

2.76e-03799185MP:0002058
MousePhenoabnormal telencephalon morphology

SOX1 TAOK1 TSHZ1 TDG TET1

2.97e-03812185MP:0000787
MousePhenoabnormal cranium morphology

TSHZ1 DLX6 COLEC10 TET1 PAX9

2.98e-03813185MP:0000438
MousePhenoabnormal craniofacial bone morphology

TSHZ1 DLX6 COLEC10 TET1 PAX9

3.21e-03827185MP:0002116
DomainTeashirt_fam

TSHZ3 TSHZ1

2.94e-063192IPR027008
DomainHomeodomain-like

TSHZ3 TSHZ1 DLX6 PAX9

3.08e-04332194IPR009057
DomainHOMEOBOX_1

TSHZ3 TSHZ1 DLX6

1.66e-03236193PS00027
DomainHOX

TSHZ3 TSHZ1 DLX6

1.68e-03237193SM00389
DomainHomeobox_dom

TSHZ3 TSHZ1 DLX6

1.72e-03239193IPR001356
DomainHOMEOBOX_2

TSHZ3 TSHZ1 DLX6

1.72e-03239193PS50071
PathwayWP_CYTOSINE_METHYLATION

TDG TET1

4.29e-058182M39348
Pubmed

Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development.

TSHZ3 TSHZ1

1.04e-06321216631416
Pubmed

Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.

TSHZ3 TSHZ1

1.04e-06321214973285
Pubmed

Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer.

TDG TET1

1.04e-06321226207381
Pubmed

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.

TDG TET1

1.04e-06321224838012
Pubmed

TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.

TDG TET1

1.04e-06321236764492
Pubmed

Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.

TSHZ3 TSHZ1

1.04e-06321219745106
Pubmed

Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex.

TDG TET1

3.47e-06521228538185
Pubmed

Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a.

TDG TET1

3.47e-06521223820384
Pubmed

FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

TSHZ3 TSHZ1

7.28e-06721219343227
Pubmed

Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain.

TSHZ3 TSHZ1

9.70e-06821215834955
Pubmed

Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.

SOX1 PAX9

1.25e-05921215520281
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

SLITRK1 TSHZ3 TSHZ1 DLX6

1.44e-0525121429031500
Pubmed

Sonic hedgehog is essential for first pharyngeal arch development.

DLX6 PAX9

2.70e-051321216492970
Pubmed

Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling.

SOX1 TET1

3.63e-051521227930333
Pubmed

Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse.

TSHZ3 TSHZ1

5.90e-051921231427287
Pubmed

Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.

SOX1 TSHZ1 DLX6

6.46e-0513021319386638
Pubmed

Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.

SOX1 TSHZ1 DLX6

7.07e-0513421319030180
Pubmed

Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal.

F2RL3 F7

7.96e-052221230870413
Pubmed

Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning.

DLX6 PAX9

8.72e-052321219235731
Pubmed

Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract.

TDG TET1

9.51e-052421223920106
Pubmed

Identification of genes controlled by LMX1B in E13.5 mouse limbs.

SLITRK1 PAX9

1.12e-042621220589901
Pubmed

Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.

SOX1 TSHZ1

1.30e-042821230796806
Pubmed

Multimodal Hox5 activity generates motor neuron diversity.

TSHZ3 TSHZ1

1.40e-042921239289460
Pubmed

A census of human transcription factors: function, expression and evolution.

SOX1 TSHZ3 TSHZ1 DLX6 PAX9

1.72e-0490821519274049
Pubmed

Gene expression profiling in the developing secondary palate in the absence of Tbx1 function.

PAX9 COX6A2

1.93e-043421229866044
Cytoband13q34

SOX1 F7

2.81e-045421213q34
CytobandEnsembl 112 genes in cytogenetic band chr13q34

SOX1 F7

7.45e-0488212chr13q34
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

TSHZ3 TSHZ1

8.67e-0515172529
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Hippocampus / BrainAtlas - Mouse McCarroll V32

SOX1 DLX6 COX6A2

5.71e-05161213b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCell10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD56bright_CD16-|GI_small-bowel / Manually curated celltypes from each tissue

F2RL3 LINC02910 COX6A2

6.03e-0516421336e64e4f717dd59b352c20ff9742ca1e232342bb
ToppCellPosterior_cortex-Neuronal-Inhibitory|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SOX1 DLX6 COX6A2

6.36e-051672139a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

SOX1 DLX6 COX6A2

6.59e-05169213c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell11.5-Airway-Epithelial-Basal_cell|Airway / Age, Tissue, Lineage and Cell class

SEMA4A PAX9 COX6A2

6.94e-051722139d4d92e2d16dfc8a394f2641653bb97de20a2530
ToppCell10x5'-GI_small-bowel-Lymphocytic_NK|GI_small-bowel / Manually curated celltypes from each tissue

F2RL3 LINC02910 COX6A2

7.18e-0517421309b216f07cffd3ea2149ea95ffb5cd7219b3a98c
ToppCellCOVID-19-kidney-Stressed_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

F2RL3 TSHZ1 NPAS4

7.81e-05179213754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCellHippocampus-Neuronal-Inhibitory|Hippocampus / BrainAtlas - Mouse McCarroll V32

SOX1 DLX6 COX6A2

8.21e-05182213b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX1 DLX6 COX6A2

8.21e-05182213f2a1784ffcba9b27132e0db21e574cbd8a0a6418
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX1 DLX6 COX6A2

8.61e-05185213739260f8abebaf10a5cc49d91726278579e26170
ToppCellMesenchymal_cells-Ng2+_MSCs|Mesenchymal_cells / Lineage and Cell class

F2RL3 F7 DLX6

8.89e-05187213e899b906409f3fad69cb3d3c6432c3fd862ae3c1
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Immature_INs|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

SOX1 DLX6 TET1

9.32e-05190213842760bfe0a52e67bad800efa7d99448a4a23ebb
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW12-Stem_cells|GW12 / Sample Type, Dataset, Time_group, and Cell type.

ANAPC1 TSHZ1 TET1

1.08e-042002134a57d6ba1531ce4e263daccd5de487977e6a1fdd
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW12-Stem_cells-Stem_cells|GW12 / Sample Type, Dataset, Time_group, and Cell type.

ANAPC1 TSHZ1 TET1

1.08e-04200213b706526b9c3485889a31253a1ffd017ad3f3fddc
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons|GW23 / Sample Type, Dataset, Time_group, and Cell type.

SOX1 TSHZ3 DLX6

1.08e-04200213c6bbd33bca86ac7a76a7ba704b3e141237d04549
ComputationalNeighborhood of JAG1

F7 PAX9 COX6A2

3.63e-059583MORF_JAG1
ComputationalNeighborhood of PPP2R5B

F2RL3 PAX9 COX6A2

2.16e-0417383MORF_PPP2R5B
ComputationalNeighborhood of BCL2L11

F2RL3 PAX9 COX6A2

2.68e-0418683MORF_BCL2L11
ComputationalNeighborhood of BCL2

F7 PAX9 COX6A2

4.57e-0422383MORF_BCL2
ComputationalNeighborhood of MT4

F7 PAX9 COX6A2

6.16e-0424783MORF_MT4
ComputationalNeighborhood of TNFRSF25

F7 PAX9 COX6A2

7.65e-0426683MORF_TNFRSF25
ComputationalNeighborhood of CAMK4

F2RL3 PAX9 COX6A2

9.84e-0429083MORF_CAMK4
ComputationalNeighborhood of ETV3

PAX9 COX6A2

9.85e-046582MORF_ETV3
ComputationalNeighborhood of MLLT10

F2RL3 PAX9 COX6A2

1.11e-0330283MORF_MLLT10
ComputationalNeighborhood of ARL3

F2RL3 PAX9 COX6A2

1.13e-0330483MORF_ARL3
ComputationalNeighborhood of ERCC4

F2RL3 PAX9 COX6A2

1.32e-0332183MORF_ERCC4
ComputationalNeighborhood of MYC

F7 PAX9

1.49e-038082MORF_MYC
ComputationalNeighborhood of PTEN

PAX9 COX6A2

1.68e-038582MORF_PTEN
ComputationalNeighborhood of KDR

F2RL3 COX6A2

2.05e-039482MORF_KDR
ComputationalNeighborhood of JAK3

F7 PAX9

2.13e-039682MORF_JAK3
ComputationalNeighborhood of RAD51L3

F2RL3 PAX9 COX6A2

2.27e-0338783MORF_RAD51L3
ComputationalNeighborhood of FOSL1

F2RL3 PAX9 COX6A2

2.60e-0340683MORF_FOSL1
ComputationalNeighborhood of PRKACA

PAX9 COX6A2

2.89e-0311282MORF_PRKACA
ComputationalNeighborhood of MAGEA9

F2RL3 PAX9 COX6A2

2.92e-0342383MORF_MAGEA9
ComputationalNeighborhood of CASP10

PAX9 COX6A2

3.15e-0311782MORF_CASP10
ComputationalNeighborhood of CD8A

F2RL3 COX6A2

3.64e-0312682MORF_CD8A
ComputationalNeighborhood of FLT1

F7 PAX9

3.64e-0312682MORF_FLT1
ComputationalNeighborhood of RAP1A

PAX9 COX6A2

4.48e-0314082MORF_RAP1A
ComputationalNeighborhood of LTK

F7 PAX9

4.93e-0314782MORF_LTK
ComputationalGenes in the cancer module 15.

F7 TDG PAX9

4.94e-0350983MODULE_16
ComputationalNeighborhood of RAGE

F7 PAX9

4.99e-0314882MORF_RAGE
ComputationalNeighborhood of RUNX1

PAX9 COX6A2

5.26e-0315282MORF_RUNX1
ComputationalNeighborhood of TNFRSF6

F2RL3 COX6A2

6.32e-0316782MORF_TNFRSF6
ComputationalNeighborhood of PSMF1

PAX9 COX6A2

6.32e-0316782MORF_PSMF1
ComputationalNeighborhood of NF1

PAX9 COX6A2

6.54e-0317082MORF_NF1
ComputationalNeighborhood of ESR1

PAX9 COX6A2

6.69e-0317282MORF_ESR1
ComputationalNeighborhood of STK17A

PAX9 COX6A2

6.69e-0317282MORF_STK17A
ComputationalNeighborhood of BNIP1

PAX9 COX6A2

8.11e-0319082MORF_BNIP1
ComputationalNeighborhood of RBBP8

F7 PAX9

1.01e-0221382MORF_RBBP8
ComputationalNeighborhood of ATRX

PAX9 COX6A2

1.03e-0221582MORF_ATRX
ComputationalNeighborhood of FDXR

F7 PAX9

1.13e-0222682MORF_FDXR
ComputationalNeighborhood of TFDP2

PAX9 COX6A2

1.17e-0223082MORF_TFDP2
ComputationalNeighborhood of IL13

PAX9 COX6A2

1.21e-0223482MORF_IL13
ComputationalNeighborhood of IL16

PAX9 COX6A2

1.26e-0223982MORF_IL16
ComputationalNeighborhood of MSH3

PAX9 COX6A2

1.30e-0224382MORF_MSH3
ComputationalNeighborhood of PTPRB

F2RL3 COX6A2

1.42e-0225482MORF_PTPRB
ComputationalNeighborhood of BRCA1

PAX9 COX6A2

1.51e-0226382MORF_BRCA1
ComputationalNeighborhood of PAX7

PAX9 COX6A2

1.55e-0226682MORF_PAX7
ComputationalNeighborhood of MDM2

PAX9 COX6A2

1.70e-0227982MORF_MDM2
ComputationalNeighborhood of FSHR

F2RL3 COX6A2

1.70e-0227982MORF_FSHR
ComputationalNeighborhood of NOS2A

PAX9 COX6A2

1.80e-0228882MORF_NOS2A
ComputationalNeighborhood of SUPT3H

F2RL3 COX6A2

2.30e-0232882MORF_SUPT3H
ComputationalNeighborhood of ATF2

F2RL3 COX6A2

2.33e-0233082MORF_ATF2
DiseasePROSTATE CANCER, HEREDITARY, 1

TSHZ1 PAX9

7.55e-0460202C4722327
DiseaseProstate cancer, familial

TSHZ1 PAX9

9.96e-0469202C2931456
DiseaseAutism Spectrum Disorders

TSHZ3 TET1

1.51e-0385202C1510586
DiseaseHypermetropia

SLITRK1 TSHZ3

2.20e-03103202HP_0000540
Diseasechronotype measurement

TUBD1 TSHZ3 TSHZ1 TET1

2.62e-03882204EFO_0008328
Diseaseautism spectrum disorder (implicated_via_orthology)

TAOK1 TSHZ3

4.71e-03152202DOID:0060041 (implicated_via_orthology)
Diseasefemoral neck bone mineral density

ANAPC1 COLEC10

7.71e-03196202EFO_0007785

Protein segments in the cluster

PeptideGeneStartEntry
AYKGHHYPGPGNHFW

TDG

146

Q13569
YSNWNEGEPSDPYGH

COLEC10

231

Q9Y6Z7
QHSPYWQADGYGHSH

LINC02910

6

Q8N268
NSYMPGYSHWYSSPH

DLX6

151

P56179
WYNVHSAPGGPSYHS

ANAPC1

641

Q9H1A4
AAPSGYVAGHGWQHA

PAX9

291

P55771
YGSGHWDPTPFSVHS

CELF2-AS1

156

Q8N7Q2
HYSDPSPSAWGNLYG

F2RL3

306

Q96RI0
GRFHAHPPGAYWAGN

NPAS4

171

Q8IUM7
PYPWGDGNHTLFHNS

COX6A2

71

Q02221
GPHATHYRGTWYLTG

F7

406

P08709
PHLSALASYYWSHGP

SEMA4A

581

Q9H3S1
SHSYPGASGWSHNPT

TAOK1

901

Q7L7X3
YAHVNGWANGAYPGS

SOX1

181

O00570
PGLAWYKPAAGHSSY

NPB

21

Q8NG41
SPYALTHVAGPYNHW

TET1

2121

Q8NFU7
GNNWAYGYSVHGPRH

TUBD1

101

Q9UJT1
SYWHNGPYNADGAHR

SLITRK1

671

Q96PX8
AWSSSYPHAPYLGSA

SORBS3

321

O60504
TPSWGGYPSIHAAYQ

TSHZ3

541

Q63HK5
PSWGGYPSIHAAYQL

TSHZ1

571

Q6ZSZ6