Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPkinase_C

ROCK2 PRKCH RPS6KB1

1.80e-0537263IPR017892
DomainPkinase_C

ROCK2 PRKCH RPS6KB1

2.65e-0542263PF00433
DomainAGC-kinase_C

ROCK2 PRKCH RPS6KB1

6.32e-0556263IPR000961
DomainAGC_KINASE_CTER

ROCK2 PRKCH RPS6KB1

6.32e-0556263PS51285
DomainS_TK_X

ROCK2 PRKCH RPS6KB1

6.32e-0556263SM00133
DomainSer/Thr_kinase_AS

ROCK2 PRKCH MAPK6 RPS6KB1

1.41e-03357264IPR008271
DomainS_TKc

ROCK2 PRKCH MAPK6 RPS6KB1

1.44e-03359264SM00220
DomainPROTEIN_KINASE_ST

ROCK2 PRKCH MAPK6 RPS6KB1

1.48e-03362264PS00108
DomainProtein_kinase_ATP_BS

ROCK2 PRKCH MAPK6 RPS6KB1

1.75e-03379264IPR017441
DomainPkinase

ROCK2 PRKCH MAPK6 RPS6KB1

1.79e-03381264PF00069
DomainC1_1

ROCK2 PRKCH

2.84e-0357262PF00130
DomainPROTEIN_KINASE_ATP

ROCK2 PRKCH MAPK6 RPS6KB1

3.50e-03459264PS00107
DomainZF_DAG_PE_1

ROCK2 PRKCH

3.56e-0364262PS00479
DomainZF_DAG_PE_2

ROCK2 PRKCH

3.56e-0364262PS50081
DomainC1

ROCK2 PRKCH

3.67e-0365262SM00109
DomainPE/DAG-bd

ROCK2 PRKCH

3.78e-0366262IPR002219
DomainProt_kinase_dom

ROCK2 PRKCH MAPK6 RPS6KB1

4.39e-03489264IPR000719
DomainPROTEIN_KINASE_DOM

ROCK2 PRKCH MAPK6 RPS6KB1

4.52e-03493264PS50011
DomainKinase-like_dom

ROCK2 PRKCH MAPK6 RPS6KB1

6.31e-03542264IPR011009
DomainKRAB

ZNF713 ZNF43 ZNF551

1.31e-02358263PS50805
DomainKRAB

ZNF713 ZNF43 ZNF551

1.31e-02358263PF01352
DomainKRAB

ZNF713 ZNF43 ZNF551

1.42e-02369263SM00349
DomainC2

PRKCH MCTP1

1.42e-02131262PF00168
DomainKRAB

ZNF713 ZNF43 ZNF551

1.43e-02370263IPR001909
Domainzf-C2H2

ZFHX3 ZNF713 ZNF43 ZNF551

1.47e-02693264PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZFHX3 ZNF713 ZNF43 ZNF551

1.47e-02694264IPR013087
DomainC2

PRKCH MCTP1

1.55e-02137262SM00239
DomainC2

PRKCH MCTP1

1.66e-02142262PS50004
Domain-

PRKCH MCTP1

1.79e-021482622.60.40.150
DomainZINC_FINGER_C2H2_2

ZFHX3 ZNF713 ZNF43 ZNF551

2.13e-02775264PS50157
DomainZINC_FINGER_C2H2_1

ZFHX3 ZNF713 ZNF43 ZNF551

2.14e-02777264PS00028
DomainC2_dom

PRKCH MCTP1

2.17e-02164262IPR000008
Pubmed

Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.

ROCK2 RPS6KB1

3.22e-06426226818518
Pubmed

A genome-wide association study for reading and language abilities in two population cohorts.

PRKCH ZFHX3

4.17e-051326223738518
Pubmed

Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.

BEX4 RPS6KB1

1.01e-042026233100228
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CACTIN ZFHX3 MCTP1 ZNF43 SLC25A13 NSD3

1.43e-04111626631753913
Pubmed

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

MAPK6 KIAA0232

2.47e-043126228089446
Pubmed

Multiple genes encoding zinc finger domains are expressed in human T cells.

ZNF43 ZNF551

2.47e-04312622288909
Pubmed

A human MAP kinase interactome.

PRKCH MAPK6 KIAA0232 NSD3

4.41e-0448626420936779
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ARFGEF3 ZFHX3 MAPK6 KIAA0232 RPS6KB1 TRPM2

6.71e-04148926628611215
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFHX3 ZNF713 ZNF43 ZNF551

4.84e-0371818428
CoexpressionTBK1.DF_DN

ROCK2 PCBD1 SLC25A13 RPS6KB1 NSD3

8.14e-06286265M2864
CoexpressionGSE14308_TH1_VS_TH17_UP

CACTIN MAPK6 DUSP22 NSD3

4.31e-05200264M3371
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ROCK2 PRKCH ZFHX3 MCTP1

4.28e-06190264a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ROCK2 PRKCH MCTP1 APOL2

4.37e-06191264a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 PRKCH MCTP1 APOL2

5.25e-0620026472ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

ROCK2 PRKCH MCTP1 APOL2

5.25e-062002646f531a418ff25b59a543800cf4bce7b72404ce08
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 PRKCH MCTP1 APOL2

5.25e-062002642d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 PRKCH MCTP1 APOL2

5.25e-062002645c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAPK6 SLC25A13 TRPM2

6.39e-05134263197599d26db97c4fe815f4812f6362e606fe347a
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell|E16.5-samps / Age Group, Lineage, Cell class and subclass

BEX4 MAPK6 PCBD1

1.29e-041702635a64e05c263df915085988d881808221e2c0f2e2
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRKCH MCTP1 APOL2

1.66e-04185263808d5e880069aff8866cd2c733b9fe568a37701f
ToppCelldroplet-Lung-LUNG-1m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 BEX4 PCBD1

1.69e-04186263e52cf44989c57c433bf82e9fa13b4643e88f3577
ToppCelldroplet-Lung-LUNG-1m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 BEX4 PCBD1

1.69e-041862634c0b59d845b79323e7a3287e7c4d249f5f322556
ToppCelldroplet-Lung-nan-18m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 BEX4 PCBD1

1.79e-04190263b057bea6e55cef872290893b6e439bbcdcee2f2e
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 BEX4 PCBD1

1.79e-04190263aaf5f1c1ff7b1454f4e5dacfeb48e1c3627e3372
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 BEX4 PCBD1

1.79e-04190263a20123d5c6cb8c2f0dfd99bbfdb571a73c36234d
ToppCellfacs-Lung-EPCAM-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 BEX4 PCBD1

1.82e-04191263629007189034ee8451411428f1c6cc57daee2d91
ToppCelldroplet-Lung-18m-Epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARFGEF3 BEX4 PCBD1

1.82e-041912631b59f1cad6c1a6a5938afa9195164918e3ff4e86
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK6 APOL2 GSDMC

1.88e-04193263463274f394757fb2570ae885d58e1f9fa7e60c4a
ToppCell5'-Adult-LargeIntestine-Hematopoietic-T_cells-TRGV2_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHST12 PRKCH PHTF1

1.91e-041942634b208bb429a1e3d58a9b757b05ef4df85a1e7f1e
ToppCellSevere-Lymphoid-T-Treg|Severe / Condition, Lineage, Cell class and cell subclass

CHST12 PRKCH NSD3

1.97e-0419626329d4db6816fead2ad9136ef824e0775463b02159
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRKCH MCTP1 TRPM2

2.00e-04197263c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCellBL-critical-LOC-Lymphoid-CTL|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CHST12 PRKCH NSD3

2.00e-04197263fb70918867fbd111bb192a797dcafed5f39ea299
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

MCTP1 SLC25A13 PHTF1

2.00e-04197263179b56147cfb0a5f53c58615f2612b8ef68c8bb8
ToppCellSevere_COVID-19-T/NK-CD4+_T_2|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

CHST12 PRKCH NSD3

2.03e-04198263c8c9343c19198b6534f8f07e74405e29b3a164bf
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CHST12 PRKCH NSD3

2.03e-0419826393773b1abbf46b39e320d628077bf94958b872a4
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CHST12 PRKCH NSD3

2.03e-04198263812ffe7369bf83ae5071970934c8831611db9557
ToppCellMS-IIF-Lymphocyte-T/NK-NK_CD56bright|IIF / Disease, condition lineage and cell class

CHST12 BEX4 PHTF1

2.06e-041992639eb2b7d4900b118338590db778a47504559e228d
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PRKCH MCTP1 APOL2

2.09e-04200263a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 PRKCH MCTP1

2.09e-04200263dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_anti-TNF-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PRKCH MCTP1 APOL2

2.09e-042002631d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCellLPS_IL1RA_TNF-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PRKCH MCTP1 APOL2

2.09e-04200263d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCellLPS_anti-TNF-Endothelial-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PRKCH MCTP1 APOL2

2.09e-0420026360d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

ROCK2 MCTP1 APOL2

2.09e-04200263edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PRKCH MCTP1 APOL2

2.09e-042002633585484c7e24e941708bee471ca607d8ccee74e6
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

PRKCH MCTP1 APOL2

2.09e-0420026381e76508c9050d533853d5fd2f3097b27613d836
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-NK_CD56bright|COVID-19_Severe / Disease, condition lineage and cell class

CHST12 PRKCH BEX4

2.09e-0420026312626d046a3ed8db1c9bd603ada5b97ead93e587
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

PRKCH MCTP1 APOL2

2.09e-042002634bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell356C-Lymphocytic-ILC-ILC-3|ILC / Donor, Lineage, Cell class and subclass (all cells)

KLHL11 BEX4

5.75e-0461262d0b33a48ee2faf68b270f9279c630437f3e8b20b
ToppCelldroplet-Liver-LIVER_NPC-30m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCBD1 POLE

1.36e-039426247e02e184a259a61c86c81503f36da243c5e3e8d
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KY TRPM2

1.82e-031092620d4128af237afcc0adb4dfdd206fa3ddbe5b0e86
ToppCellThalamus|World / BrainAtlas - Mouse McCarroll V32

PRKCH ZFHX3

2.06e-031162625ddfb2dd5459ff6d7ae38163a38eae64fda283b7
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAPK6 TRPM2

2.16e-03119262e6f1b9f29dc8fe6b6132c7885234c385159da393
ToppCellMild/Remission-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

KY NSD3

2.23e-0312126268940a552233d255b90ce5a081339c0d9d46ab02
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRKCH MAPK6

2.23e-03121262b6dada0712b1f9793bc61e54ec7f10c9eaf53b86
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Sema3c|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GSDMC SLC25A13

2.27e-03122262eae9d94f8510ac0f434942451d55c7260977b178
ToppCellLPS_only-Lymphocytic_NKT-T_cells-iNKT-MAIT|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CHST12 GSDMC

2.35e-0312426205e114fcfe84cfc8d92978a4eda6db4d8a616e0e
ToppCelldroplet-Heart-HEART-1m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP1 SLC25A13

2.46e-03127262983489a69d3b1f1fe21110a862ac1dba53e9d31c
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KY NSD3

2.61e-03131262a3a086ce6e69707ca6a042f3b15c130f81909acb
ToppCellCOVID-19_Mild-Neu_2|World / 5 Neutrophil clusters in COVID-19 patients

ARFGEF3 KLHL11

2.98e-03140262b1429028c52f84127b894b93b55961badcd5246f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DUSP22 TRPM2

3.06e-03142262199a0a1024b6cc446f5ca1f277846a2bdb227a9f
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ARFGEF3 TRPM2

3.10e-031432624622c221b5d2d4cd4f37e4f81662e073924e1507
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARFGEF3 TRPM2

3.10e-031432629836a040a2ebcf6f05431e658a7b8fd566621452
ToppCellBAL-Control-cDC_4|Control / Compartment, Disease Groups and Clusters

KLHL11 ZFHX3

3.19e-031452623b2a2965dc18abd39d5ed70c0fcad0210e7f12c8
ToppCell356C-Lymphocytic-NK_cells-NK_cell_D3|356C / Donor, Lineage, Cell class and subclass (all cells)

GLIPR1L1 ZNF551

3.27e-03147262551c249f921ee0e70208abe207f2044d234d1ddc
ToppCell356C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GLIPR1L1 ZNF551

3.40e-03150262580ed7733857402345f43ca2623f72cdd1edf22c
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-neutrophil|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP1 TRPM2

3.40e-031502626e806a028c0519489151c181d9907e05289e27e0
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma|TCGA-Uterus / Sample_Type by Project: Shred V9

ARFGEF3 GSDMC

3.45e-031512622810bfa01bd3016aeba29735eb4a9284792e8aac
ToppCellP03-Epithelial-epithelial_progenitor_cell-epi_progenitor|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BEX4 PCBD1

3.45e-03151262fce04bce66411c21cd5d4d41375f26f1f50f3348
ToppCell390C-Lymphocytic-NK_cells-NK_cell_D2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

BEX4 ZNF713

3.49e-03152262595afcfa8b161e291fcaf2afc7336bac9b6fae0f
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Cpa6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZFHX3 MCTP1

3.58e-0315426212cbc38bc1f7231c67e1d2d5e86e95bc12e24682
ToppCellLeuk-UTI-Lymphocyte-T_NK-CD4_CTL|Leuk-UTI / Disease, Lineage and Cell Type

CHST12 PRKCH

3.58e-03154262170a421fd69dba2929568c72e983ae9cfaf2aabc
ToppCellP28-Epithelial-epithelial_progenitor_cell-epi_progenitor|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ARFGEF3 BEX4

3.63e-03155262be575a0096415705dba425002247289ff8f89474
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Sema3c|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GSDMC SLC25A13

3.63e-031552625c7b68b59244525e3714806c205a57a2daebf423
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX3 SLC25A13

3.68e-0315626258b9520fce6e259b36c3d59e82b712f5e7729e3e
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

ZNF43 POLE

3.68e-0315626219472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCellfacs-Spleen-nan-3m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP1 TRPM2

3.68e-03156262f532ef4e92ac7661b1a8a4f2e98d80ce8d4e3655
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZFHX3 MCTP1

3.68e-03156262fe383ce3a0c37f7343d7026cb51260a04d4c2829
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BEX4 POLE

3.68e-03156262b28bbdb515317368f1231b0b15d7442352f3b400
ToppCellPND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCTP1 SLC25A13

3.68e-03156262af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCellfacs-Spleen-nan-3m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP1 TRPM2

3.68e-03156262da4f35353a84d919e683554932f110e29568df33
ToppCellfacs-Spleen-nan-3m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP1 TRPM2

3.68e-03156262f1e25ff85c5f2f8555f9fb5ae5daed7ddb418fd1
ToppCellfacs-Heart-Unknown-3m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSDMC POLE

3.72e-031572622ac4695d9e4ca8d4ba19c555e9a1d86ac8f398ab
ToppCellfacs-Heart-Unknown-3m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSDMC POLE

3.72e-031572628a393eece90fb9a1b7c356736bdb36277261fbd3
ToppCell368C-Lymphocytic-NK_cells|368C / Donor, Lineage, Cell class and subclass (all cells)

PRKCH ZNF713

3.72e-03157262ef5c0ace4cd500b6cc50fb7076298f3d3543b40c
ToppCellfacs-Heart-Unknown-3m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSDMC POLE

3.72e-031572628d30d8e6fae93afcada6bd68799439335cd65b69
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACTIN POLE

3.77e-031582622ae863ccef201414b82a2ecf7cf1bbb1b0ce4a3c
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-CD45|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP1 TRPM2

3.77e-03158262e0b862e4b9ebaa12869640b5d18d5fa852861bef
ToppCellLeuk-UTI-Lymphocyte-T_NK-gdT|Leuk-UTI / Disease, Lineage and Cell Type

CHST12 PRKCH

3.77e-03158262c4b0af25608cee3d0d2b0193f5ff45d9dc87078b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ROCK2 PHTF1

3.77e-031582624d997efc36fd8946775fe74dd9ac9ccd5ade64ff
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GLIPR1L1 PHTF1

3.86e-031602629049707a4487f2337a17976ceb5fbd8815ab9e1d
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GLIPR1L1 PHTF1

3.86e-03160262f2cfec54cf48a655f473b830be7d141c54b521ff
ToppCellICU-NoSEP-Lymphocyte-T_NK-gdT|ICU-NoSEP / Disease, Lineage and Cell Type

CHST12 PRKCH

3.86e-031602622798c5bd971407f27dd4d3a4831d63d9c88003c3
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GLIPR1L1 PHTF1

3.86e-031602620eb50b3c494e1b65d40104b3b5411b57bb72b959
ToppCelldroplet-Marrow-BM-30m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX3 DUSP22

3.86e-03160262822adcf5f9208f305cafffd8ed97f3a061e82b03
ToppCellCV-Healthy-3|CV / Virus stimulation, Condition and Cluster

CACTIN BEX4

3.91e-03161262fd4a79385ea967b9900dc76a3add813b894a3a28
ToppCellIIF-Lymphocyte-T_NK-NK_CD56bright|IIF / Disease, Lineage and Cell Type

CHST12 BEX4

3.91e-03161262b1bd1074ecba4cf171d748e2f686e9a99c0f0e89
ToppCelldroplet-Thymus-nan-21m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCTP1 TRPM2

3.91e-03161262441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZFHX3 MCTP1

3.96e-0316226258da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCelldroplet-Marrow-BM-30m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DUSP22 KIAA0232

3.96e-0316226275df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX3 SLC25A13

3.96e-03162262ded08da888d8c481f0f96d1e0bfd03d617966910
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B2|367C / Donor, Lineage, Cell class and subclass (all cells)

CHST12 PRKCH

3.96e-0316226259c0dcb5b51c1803660aeec51b60deceeeaeea66
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZFHX3 MCTP1

3.96e-031622624d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCelldroplet-Marrow-BM-30m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX3 DUSP22

3.96e-0316226276e289ad9fd3694f77fd0d19e74c1cb8e87b8094
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZFHX3 MCTP1

4.00e-03163262b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B2|390C / Donor, Lineage, Cell class and subclass (all cells)

CHST12 PRKCH

4.00e-03163262036e65de0f8fc391f3e4d299bf4c05ee5c3b5a37
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRKCH PHTF1

4.00e-0316326211cc18f36604d9a5f4e7fb8626a8f0fb141da5e1
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL11 TRPM2

4.00e-031632627a04192710f55acf5a4681d5f09942358fdb02ff
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

APOL2 GSDMC

4.00e-03163262d005115aa1e1458b51de7eb719794617a4168608
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL11 ZFHX3

4.05e-0316426243630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL11 ZFHX3

4.05e-03164262108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL11 ZFHX3

4.05e-0316426246208f18325976c89f572f6627aea0582142b92d
DrugMephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; PC3; HT_HG-U133A

ROCK2 PRKCH BEX4 NSD3 TRPM2

2.55e-061962653685_DN
DrugPyridoxine hydrochloride [58-56-0]; Down 200; 19.4uM; MCF7; HT_HG-U133A

ROCK2 CHST12 PRKCH BEX4 ZFHX3

2.62e-061972657171_DN
DrugConvolamine hydrochloride [500-56-1]; Down 200; 11.8uM; PC3; HT_HG-U133A

ROCK2 ZFHX3 MCTP1 NSD3 TRPM2

2.75e-061992655876_DN
DrugEthacrynic acid [58-54-8]; Up 200; 13.2uM; HL60; HG-U133A

APOL2 PCBD1 KIAA0232 PHTF1

5.72e-051872641565_UP
DrugAlverine citrate salt [5560-59-8]; Down 200; 8.4uM; PC3; HT_HG-U133A

ROCK2 ZFHX3 MCTP1 APOL2

6.47e-051932646345_DN
DrugAmikacin hydrate [37517-28-5]; Down 200; 6.6uM; PC3; HT_HG-U133A

CACTIN PRKCH BEX4 TRPM2

6.60e-051942646715_DN
Drug5279552; Down 200; 22uM; MCF7; HT_HG-U133A_EA

CACTIN BEX4 ZFHX3 APOL2

6.73e-05195264843_DN
DrugTetrahydroalstonine [6474-90-4]; Down 200; 11.4uM; PC3; HT_HG-U133A

CACTIN ZFHX3 APOL2 KIAA0232

6.86e-051962645728_DN
DrugTetrahydroxy-1,4-quinone monohydrate [319-89-1]; Down 200; 21uM; MCF7; HT_HG-U133A

ROCK2 PRKCH POLE NSD3

7.00e-051972643338_DN
DrugAconitine [302-27-2]; Down 200; 6.2uM; PC3; HT_HG-U133A

CACTIN APOL2 ZNF43 KIAA0232

7.00e-051972647149_DN
DrugMerbromin [129-16-8]; Down 200; 5uM; MCF7; HT_HG-U133A

CACTIN BEX4 APOL2 NSD3

7.00e-051972643439_DN
DrugDesipramine hydrochloride [58-28-6]; Down 200; 13.2uM; HL60; HG-U133A

ROCK2 POLE NSD3 TRPM2

7.14e-051982641596_DN
DrugIopamidol [60166-93-0]; Down 200; 5.2uM; MCF7; HT_HG-U133A

ROCK2 CHST12 CACTIN NSD3

7.14e-051982647189_DN
Drugcatechin; Down 200; 11uM; MCF7; HT_HG-U133A_EA

ROCK2 CHST12 ZNF43 KIAA0232

7.14e-051982641101_DN
DrugN6,2-O-dibutyryladenosine 3,5-cyclic monophosphate sodium salt; Down 200; 2uM; MCF7; HT_HG-U133A_EA

BEX4 ZFHX3 APOL2 ZNF551

7.14e-05198264842_DN
DrugAscorbic acid [50-81-7]; Down 200; 22.4uM; PC3; HT_HG-U133A

CACTIN PRKCH APOL2 KIAA0232

7.28e-051992646306_DN
DrugMeropenem [96036-03-2]; Down 200; 10.4uM; PC3; HT_HG-U133A

CACTIN MCTP1 APOL2 KIAA0232

7.28e-051992645824_DN
DrugTrapidil [15421-84-8]; Down 200; 19.4uM; MCF7; HT_HG-U133A

CHST12 CACTIN PRKCH PHTF1

7.42e-052002647475_DN
DrugPkcs

ROCK2 PRKCH MAPK6 RPS6KB1

9.13e-05211264CID000164073
DrugPD98059

ROCK2 PRKCH MAPK6 RPS6KB1

1.34e-04233264CID000004713
Diseaserheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement

DUSP22 PHTF1

1.30e-0363252EFO_0000685, EFO_0007791, EFO_0009459
Diseaseword reading

PRKCH ZFHX3

1.39e-0365252EFO_0005300
Diseasemultiple sclerosis

CHST12 ZFHX3 MCTP1 RPS6KB1

1.47e-03594254MONDO_0005301
DiseaseAdenocarcinoma of large intestine

PRKCH POLE

2.99e-0396252C1319315
Diseaselung non-small cell carcinoma (is_implicated_in)

ZFHX3 POLE

6.16e-03139252DOID:3908 (is_implicated_in)
Diseaserheumatoid arthritis

PRKCH DUSP22 PHTF1

6.79e-03462253EFO_0000685
Diseaseblood phosphate measurement

ZFHX3 RPS6KB1

9.49e-03174252EFO_0010972

Protein segments in the cluster

PeptideGeneStartEntry
HDKDQQHRQWFLKEF

APOL2

71

Q9BQE5
NFRWAIPNRHIEHNE

BEX4

61

Q9NWD9
PFWQNFKHLQEEVFQ

GSDMC

311

Q9BYG8
KTLNPQWREQFDFHL

MCTP1

511

Q6DN14
ALFIEDHFPDNKNWQ

KY

311

Q8NBH2
QAEKLDHHPEWFNVY

PCBD1

56

P61457
HRQLWKPFVSFEQND

KIAA0232

986

Q92628
QFSEHDWPVHNNFDI

MAPK6

361

Q16659
VQAHPFFRHINWEEL

RPS6KB1

346

P23443
NEPDEAHLIQRWFEH

POLE

336

Q07864
FVDEDRWVNLPHIHN

KLHL11

381

Q9NVR0
LTDWNEPPHFHFNEA

ARFGEF3

1241

Q5TH69
QEFEKHEVHQYRQWL

DUSP22

136

Q9NRW4
PHFIDNCIEAHNEWR

GLIPR1L1

31

Q6UWM5
HFKTWEEQEDNFHLQ

CACTIN

276

Q8WUQ7
IHQHIPFNWDSEFVQ

SLC25A13

121

Q9UJS0
HTEKLAPFNEHWRQV

CHST12

311

Q9NRB3
PKEDVFQQNHLFWLQ

PHTF1

416

Q9UMS5
QEHTDQIWKFQRHDL

TRPM2

1056

O94759
DLHQHQKHYNEEEPW

ZNF551

146

Q7Z340
EEIRQHPFFKNDQWH

ROCK2

346

O75116
QFFSNQPERAWVHEK

NSD3

311

Q9BZ95
HFTQDFWPEQHIKDP

ZNF43

81

P17038
LWDFDYHPEFNQENH

ZNF713

146

Q8N859
KLAFPSFEHWQEHQQ

ZFHX3

2536

Q15911
HPFFKEIDWAQLNHR

PRKCH

611

P24723