Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlipid binding

PTEN ESYT2 PDZD8 SLC38A9

9.84e-04988104GO:0008289
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP2D6 KDM5B

4.01e-03194102GO:0016705
GeneOntologyBiologicalProcesslipid transport

ESYT2 MAPK9 PDZD8 KDM5B

6.68e-05506104GO:0006869
GeneOntologyBiologicalProcesslipid localization

ESYT2 MAPK9 PDZD8 KDM5B

1.03e-04565104GO:0010876
GeneOntologyBiologicalProcesscircadian rhythm

PTEN MAPK9 KDM5B

1.94e-04248103GO:0007623
GeneOntologyBiologicalProcessregulation of secretion

MAPK9 GRM8 TFF2 KDM5B

3.93e-04801104GO:0051046
GeneOntologyBiologicalProcessFc receptor signaling pathway

PTEN MAPK9

3.94e-0462102GO:0038093
GeneOntologyBiologicalProcesslipid export from cell

MAPK9 KDM5B

4.20e-0464102GO:0140353
GeneOntologyBiologicalProcessrhythmic process

PTEN MAPK9 KDM5B

5.78e-04360103GO:0048511
GeneOntologyBiologicalProcessorganelle localization by membrane tethering

ESYT2 PDZD8

7.39e-0485102GO:0140056
GeneOntologyBiologicalProcessmembrane docking

ESYT2 PDZD8

8.47e-0491102GO:0022406
GeneOntologyCellularComponentorganelle membrane contact site

ESYT2 PDZD8

3.24e-0457102GO:0044232
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

PTEN ESYT2

3.35e-03185102GO:0009898
GeneOntologyCellularComponentcytoplasmic side of membrane

PTEN ESYT2

5.12e-03230102GO:0098562
MousePhenoenlarged cerebellum

PTEN PDZD8

1.72e-06482MP:0008914
MousePhenoreduced long-term potentiation

PTEN MAPK9 PDZD8

5.42e-0514183MP:0001473
MousePhenodecreased paired-pulse facilitation

MAPK9 PDZD8

8.54e-052582MP:0002920
MousePhenoabnormal long-term potentiation

PTEN MAPK9 PDZD8

2.06e-0422183MP:0002207
MousePhenoincreased stereotypic behavior

PTEN PDZD8

3.89e-045382MP:0001409
MousePhenoabnormal paired-pulse facilitation

MAPK9 PDZD8

5.33e-046282MP:0002918
DomainC2_dom

PTEN ESYT2

3.29e-03164102IPR000008
Pubmed

KDM5B Is Essential for the Hyperactivation of PI3K/AKT Signaling in Prostate Tumorigenesis.

PTEN KDM5B

7.44e-08210232868382
Pubmed

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.

PTEN MAPK9

1.56e-06710222753496
Pubmed

JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression.

PTEN MAPK9

2.68e-06910231089135
Pubmed

Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages.

PTEN MAPK9

4.09e-061110218322234
Pubmed

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.

PTEN MAPK9

2.41e-052610221367821
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PTEN ESYT2 MAPK9 PDZD8

1.49e-04104910427880917
InteractionRAB3GAP1 interactions

PTEN ESYT2 PDZD8

3.42e-0515293int:RAB3GAP1
InteractionCLCC1 interactions

PTEN ESYT2 PDZD8

6.65e-0519093int:CLCC1
InteractionRAB5C interactions

PTEN ESYT2 PDZD8 SLC38A9

8.70e-0560094int:RAB5C
InteractionLAMP2 interactions

PTEN ESYT2 PDZD8 SLC38A9

9.22e-0560994int:LAMP2
InteractionELL2 interactions

PTEN ESYT2

9.29e-053392int:ELL2
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Neuronal|GW08 / Sample Type, Dataset, Time_group, and Cell type.

PTEN KDM5B

1.39e-04801025c39136f5f855efbf61e1f5348ea97ea2130b241
ToppCellControl-Fibroblasts-Pericytes|Control / group, cell type (main and fine annotations)

PTEN GRM8

6.33e-04171102080003f698f867935c2bfc55d241d3650f45a0ab
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESYT2 KDM5B

7.41e-04185102d50406a9a5b8d75110ba5985741aa2293950c543
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESYT2 KDM5B

7.41e-04185102a2cae8c657e4f4d121476798e424876f7e247973
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTEN SLC38A9

7.56e-041871023699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTEN SLC38A9

7.56e-04187102033ba52c0c2f9978784947098fa697368ae44834
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CYP2D6 KDM5B

7.65e-04188102e239bcdbd210a398a5850cb6fbf171d402f45a4f
ToppCellCOVID_vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

PDZD8 KDM5B

7.73e-041891022157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTEN GRM8

7.97e-0419210209cb5b89a164ac7444774ccc8c90323c8ea2026b
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTEN PDZD8

8.05e-0419310206b65110db974f4ef90d3511ff34428976a52c9c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTEN GRM8

8.05e-041931022ddf9b2770a0be9689e01d1a3d19e4a6d42c7a50
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTEN GRM8

8.05e-04193102dd4bac8a93a5b9dcf7301f1d7d6e3eb6670f5c68
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTEN PDZD8

8.05e-041931029c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCellfacs-Brain_Myeloid-Hippocampus-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTEN PDZD8

8.05e-04193102a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTEN PDZD8

8.05e-04193102b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTEN GRM8

8.22e-04195102d760d1423f9a8a373fe7b250ea9b1d67a0c0059f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTEN GRM8

8.30e-04196102cb61757646653f89faba503cb5d99e5dd5197b4c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTEN GRM8

8.30e-0419610244e2df1b61e3819eae7e482bef0a733afe852d67
ToppCellControl-Control-Others-HSPC|Control / Disease, condition lineage and cell class

PDZD8 KDM5B

8.56e-04199102b71169be0d916b2ed139a3122d78bb154c71edb4
DrugHemin

PTEN MAPK9 CYP2D6

7.03e-0690103ctd:D006427
Drug1-methyl-4-phenylpyridinium

MAPK9 GRM8 CYP2D6

2.88e-05144103CID000039484
Drugveliparib

PTEN CYP2D6

3.99e-0522102ctd:C521013
DrugNPS R-568

GRM8 CYP2D6

6.06e-0527102CID000158796
Drugsalvin

PTEN MAPK9

1.41e-0441102ctd:C018381
Druggefitinib

PTEN MAPK9 TFF2

1.57e-04255103CID000123631
DrugAC1O4QII

PTEN MAPK9

1.63e-0444102CID006398468
Drug1tom

PTEN TFF2

2.19e-0451102CID000448763
DrugRacemic mixture

GRM8 CYP2D6

2.83e-0458102CID000365464
Drugethanol

PTEN MAPK9 TFF2 CYP2D6

3.19e-04837104CID000000702
DrugAC1L89QG

GRM8 CYP2D6

3.89e-0468102CID000323970
Drugdopamine quinone

MAPK9 CYP2D6

4.01e-0469102CID000162602
DrugBenzene

PTEN MAPK9 CYP2D6 KDM5B

4.07e-04892104ctd:D001554
DrugAM251

MAPK9 GRM8

4.13e-0470102CID000002125
DrugRotenone

PTEN MAPK9 GRM8 KDM5B

5.77e-04978104ctd:D012402
Drugrimonabant

GRM8 TFF2

5.94e-0484102CID000104849
Druggarlic oil

MAPK9 CYP2D6

5.94e-0484102CID000011617
Drug3-aminophenylboronic acid

GRM8 TFF2

6.08e-0485102CID000092269
Drugnogalonic acid methyl ester

PTEN CYP2D6

6.37e-0487102CID000443820
DrugAG213

MAPK9 TFF2

6.66e-0489102CID005328803
Druganiline

MAPK9 CYP2D6

7.12e-0492102ctd:C023650
DrugHydrochloric Acid

TFF2 KDM5B

7.43e-0494102ctd:D006851
Druglevo-dromoran tartrate

GRM8 CYP2D6

8.07e-0498102CID000003918
Drugticlopidine

TFF2 CYP2D6

8.91e-04103102CID000005472
Drugracemethorphan

GRM8 CYP2D6

9.61e-04107102CID000003008
Drugmorphine hydrochloride

MAPK9 GRM8 CYP2D6

1.01e-03481103CID000004253
DrugHU-211

MAPK9 GRM8

1.09e-03114102CID000107778
Drughydroxybutyrate

MAPK9 TFF2

1.11e-03115102CID000010413
Drug2-arachidonoylglycerol (2-AG

MAPK9 GRM8

1.19e-03119102CID000001541
Drug1c88

MAPK9 CYP2D6

1.33e-03126102CID000444766
DrugAsbestos, Crocidolite

PTEN MAPK9 GRM8 KDM5B

1.42e-031241104ctd:D017638
Drugethylnylestradiol

PTEN MAPK9 TFF2 CYP2D6

1.46e-031251104CID000003285
Drugcarvedilol

MAPK9 CYP2D6

1.54e-03136102ctd:C043211
Drugethyl acetate

MAPK9 GRM8

1.57e-03137102CID000008857
Drugmangiferin

MAPK9 CYP2D6

1.71e-03143102ctd:C013592
Diseasesyndromic intellectual disability (implicated_via_orthology)

PDZD8 KDM5B

9.90e-061692DOID:0050888 (implicated_via_orthology)
Diseaseprostate cancer (is_marker_for)

PTEN TFF2 KDM5B

1.19e-0515693DOID:10283 (is_marker_for)
DiseaseAutistic Disorder

PTEN GRM8 KDM5B

5.53e-0526193C0004352
Diseasehigh grade glioma (is_implicated_in)

PTEN KDM5B

7.08e-054292DOID:3070 (is_implicated_in)
DiseaseSquamous cell carcinoma of the head and neck

PTEN MAPK9

1.09e-045292C1168401
DiseaseSmall cell carcinoma of lung

PTEN GRM8

1.17e-045492C0149925
DiseaseDystonia

PTEN CYP2D6

2.98e-048692C0013421
DiseaseReperfusion Injury

PTEN MAPK9

3.19e-048992C0035126
DiseaseAdenocarcinoma of large intestine

PTEN MAPK9

3.72e-049692C1319315
Diseaseurinary bladder cancer (is_marker_for)

PTEN KDM5B

4.61e-0410792DOID:11054 (is_marker_for)
Diseasebreast cancer (is_implicated_in)

PTEN KDM5B

9.03e-0415092DOID:1612 (is_implicated_in)
Diseaseautism spectrum disorder (implicated_via_orthology)

PTEN KDM5B

9.27e-0415292DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
EPVWEENFTFFIHNP

ESYT2

581

A0FGR8
FEELFPDWIFPSESE

MAPK9

271

P45984
VPFTHWFFSFVEDPL

PDZD8

236

Q8NEN9
WFFSFVEDPLIDFEV

PDZD8

241

Q8NEN9
EPSWEEFADPFAFIH

KDM5B

36

Q9UGL1
FVWFVVDPPHIIIDY

GRM8

711

O00222
EAVWEKPFRFHPEHF

CYP2D6

406

P10635
EFHWFIPTEFFVPEI

SLC38A9

341

Q8NBW4
FHFWVNTFFIPGPEE

PTEN

271

P60484
LEDVHIWIGVPFFFV

OR52E8

26

Q6IFG1
FIFEVPWCFFPKSVE

TFF2

111

Q03403