Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	ATP13A5 DNAH10 DDX21 ATP5F1A ABCB5 ABCB4	1.97e-04	441	39	6	GO:0016887
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHB2 ROR2 EPHB1	2.77e-04	65	39	3	GO:0004714
GeneOntologyMolecularFunction	axon guidance receptor activity	EPHB2 EPHB1	2.86e-04	13	39	2	GO:0008046
GeneOntologyMolecularFunction	transmembrane-ephrin receptor activity	EPHB2 EPHB1	3.84e-04	15	39	2	GO:0005005
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	EPHB2 ROR2 EPHB1	6.09e-04	85	39	3	GO:0019199
GeneOntologyMolecularFunction	ephrin receptor activity	EPHB2 EPHB1	6.22e-04	19	39	2	GO:0005003
GeneOntologyMolecularFunction	ATP-dependent activity	ATP13A5 DNAH10 DDX21 ATP5F1A ABCB5 ABCB4	1.13e-03	614	39	6	GO:0140657
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ATP13A5 ABCB5 ABCB4	1.25e-03	109	39	3	GO:0042626
GeneOntologyMolecularFunction	protein tyrosine kinase activity	EPHB2 ROR2 EPHB1	2.83e-03	145	39	3	GO:0004713
GeneOntologyMolecularFunction	peptide binding	EPHB2 CSNK1A1L CTSL CSNK1A1	3.35e-03	318	39	4	GO:0042277
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ATP13A5 DNAH10 DDX21 ATP5F1A ABCB5 ABCB4	3.66e-03	775	39	6	GO:0017111
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCB5 ABCB4	4.13e-03	49	39	2	GO:0140359
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ATP13A5 ABCB5 ABCB4	5.03e-03	178	39	3	GO:0015399
GeneOntologyMolecularFunction	pyrophosphatase activity	ATP13A5 DNAH10 DDX21 ATP5F1A ABCB5 ABCB4	5.39e-03	839	39	6	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ATP13A5 DNAH10 DDX21 ATP5F1A ABCB5 ABCB4	5.42e-03	840	39	6	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ATP13A5 DNAH10 DDX21 ATP5F1A ABCB5 ABCB4	5.42e-03	840	39	6	GO:0016818
GeneOntologyMolecularFunction	protein kinase activity	EPHB2 CSNK1A1L CSNK1A1 ROR2 EPHB1	5.96e-03	600	39	5	GO:0004672
GeneOntologyBiologicalProcess	negative regulation of NMDA glutamate receptor activity	EPHB2 SLC6A9	3.48e-06	2	39	2	GO:1904782
GeneOntologyBiologicalProcess	regulation of NMDA receptor activity	EPHB2 SLC6A9 RELN	5.00e-06	18	39	3	GO:2000310
GeneOntologyBiologicalProcess	hindbrain tangential cell migration	EPHB2 EPHB1	3.47e-05	5	39	2	GO:0021934
GeneOntologyBiologicalProcess	optic nerve morphogenesis	EPHB2 EPHB1	5.20e-05	6	39	2	GO:0021631
GeneOntologyBiologicalProcess	regulation of neurotransmitter receptor activity	EPHB2 SLC6A9 RELN	1.62e-04	56	39	3	GO:0099601
GeneOntologyBiologicalProcess	modulation of chemical synaptic transmission	EPHB2 SLC6A9 RELN ZDHHC17 NALCN ROR2 EPHB1	2.16e-04	663	39	7	GO:0050804
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling	EPHB2 SLC6A9 RELN ZDHHC17 NALCN ROR2 EPHB1	2.18e-04	664	39	7	GO:0099177
GeneOntologyBiologicalProcess	regulation of TOR signaling	PKHD1 RELN CSNK1A1L CSNK1A1	2.21e-04	158	39	4	GO:0032006
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	EPHB2 SLC6A9 RELN ZDHHC17 NALCN ROR2 NTSR1 EPHB1	2.95e-04	931	39	8	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	EPHB2 SLC6A9 RELN ZDHHC17 NALCN ROR2 NTSR1 EPHB1	2.95e-04	931	39	8	GO:0007268
GeneOntologyBiologicalProcess	trans-synaptic signaling	EPHB2 SLC6A9 RELN ZDHHC17 NALCN ROR2 NTSR1 EPHB1	3.13e-04	939	39	8	GO:0099537
GeneOntologyBiologicalProcess	TOR signaling	PKHD1 RELN CSNK1A1L CSNK1A1	3.71e-04	181	39	4	GO:0031929
GeneOntologyBiologicalProcess	synaptic signaling	EPHB2 SLC6A9 RELN ZDHHC17 NALCN ROR2 NTSR1 EPHB1	4.06e-04	976	39	8	GO:0099536
GeneOntologyBiologicalProcess	positive regulation of TOR signaling	RELN CSNK1A1L CSNK1A1	4.31e-04	78	39	3	GO:0032008
GeneOntologyBiologicalProcess	dendritic spine morphogenesis	EPHB2 RELN EPHB1	4.82e-04	81	39	3	GO:0060997
GeneOntologyBiologicalProcess	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	FBXO22 CSNK1A1L CSNK1A1	5.55e-04	85	39	3	GO:0032436
GeneOntologyBiologicalProcess	negative regulation of NLRP3 inflammasome complex assembly	CSNK1A1L CSNK1A1	5.84e-04	19	39	2	GO:1900226
GeneOntologyBiologicalProcess	positive regulation of small GTPase mediated signal transduction	RELN CSNK1A1L CSNK1A1	6.99e-04	92	39	3	GO:0051057
GeneOntologyBiologicalProcess	negative regulation of inflammasome-mediated signaling pathway	CSNK1A1L CSNK1A1	7.15e-04	21	39	2	GO:0141086
GeneOntologyBiologicalProcess	regulation of ERK1 and ERK2 cascade	EPHB2 PKHD1 ZDHHC17 ROR2 EPHB1	7.54e-04	385	39	5	GO:0070372
GeneOntologyBiologicalProcess	regulation of synapse organization	EPHB2 RELN ZDHHC17 ROR2 EPHB1	7.72e-04	387	39	5	GO:0050807
GeneOntologyBiologicalProcess	optic nerve development	EPHB2 EPHB1	7.86e-04	22	39	2	GO:0021554
GeneOntologyBiologicalProcess	positive regulation of proteolysis	FBXO22 CSNK1A1L CTSL KLKB1 CSNK1A1	7.99e-04	390	39	5	GO:0045862
GeneOntologyBiologicalProcess	regulation of synapse structure or activity	EPHB2 RELN ZDHHC17 ROR2 EPHB1	8.46e-04	395	39	5	GO:0050803
GeneOntologyBiologicalProcess	cell migration in hindbrain	EPHB2 EPHB1	8.60e-04	23	39	2	GO:0021535
Domain	RECEPTOR_TYR_KIN_V_2	EPHB2 EPHB1	3.81e-04	14	39	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB2 EPHB1	3.81e-04	14	39	2	PS00790
Domain	EphA2_TM	EPHB2 EPHB1	3.81e-04	14	39	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB2 EPHB1	3.81e-04	14	39	2	IPR016257
Domain	Eph_TM	EPHB2 EPHB1	3.81e-04	14	39	2	IPR027936
Domain	Ephrin_rcpt_lig-bd_dom	EPHB2 EPHB1	3.81e-04	14	39	2	IPR001090
Domain	Tyr_kinase_rcpt_V_CS	EPHB2 EPHB1	3.81e-04	14	39	2	IPR001426
Domain	EPH_LBD	EPHB2 EPHB1	3.81e-04	14	39	2	PS51550
Domain	EPH_lbd	EPHB2 EPHB1	3.81e-04	14	39	2	SM00615
Domain	Ephrin_lbd	EPHB2 EPHB1	3.81e-04	14	39	2	PF01404
Domain	-	EPHB2 LAMC1 EPHB1	4.73e-04	73	39	3	2.60.120.260
Domain	TyrKc	EPHB2 ROR2 EPHB1	8.17e-04	88	39	3	SM00219
Domain	Tyr_kinase_cat_dom	EPHB2 ROR2 EPHB1	8.17e-04	88	39	3	IPR020635
Domain	Galactose-bd-like	EPHB2 LAMC1 EPHB1	9.89e-04	94	39	3	IPR008979
Domain	PROTEIN_KINASE_TYR	EPHB2 ROR2 EPHB1	1.08e-03	97	39	3	PS00109
Domain	Tyr_kinase_AS	EPHB2 ROR2 EPHB1	1.08e-03	97	39	3	IPR008266
Domain	ABC_membrane	ABCB5 ABCB4	1.14e-03	24	39	2	PF00664
Domain	Ephrin_rec_like	EPHB2 EPHB1	1.24e-03	25	39	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB2 EPHB1	1.24e-03	25	39	2	IPR011641
Domain	ABC_TM1F	ABCB5 ABCB4	1.55e-03	28	39	2	PS50929
Domain	ABC1_TM_dom	ABCB5 ABCB4	1.55e-03	28	39	2	IPR011527
Domain	EGF_2	EPHB2 LAMC1 RELN EPHB1	2.21e-03	265	39	4	PS01186
Domain	Pkinase_Tyr	EPHB2 ROR2 EPHB1	2.45e-03	129	39	3	PF07714
Domain	PROTEIN_KINASE_ATP	EPHB2 CSNK1A1L CSNK1A1 ROR2 EPHB1	2.54e-03	459	39	5	PS00107
Domain	Ser-Thr/Tyr_kinase_cat_dom	EPHB2 ROR2 EPHB1	2.97e-03	138	39	3	IPR001245
Domain	Prot_kinase_dom	EPHB2 CSNK1A1L CSNK1A1 ROR2 EPHB1	3.33e-03	489	39	5	IPR000719
Domain	AAA+_ATPase	DNAH10 ABCB5 ABCB4	3.35e-03	144	39	3	IPR003593
Domain	AAA	DNAH10 ABCB5 ABCB4	3.35e-03	144	39	3	SM00382
Domain	PROTEIN_KINASE_DOM	EPHB2 CSNK1A1L CSNK1A1 ROR2 EPHB1	3.45e-03	493	39	5	PS50011
Domain	ABC_transporter_CS	ABCB5 ABCB4	3.47e-03	42	39	2	IPR017871
Domain	-	TYW1 NAGA	3.47e-03	42	39	2	3.20.20.70
Domain	Aldolase_TIM	TYW1 NAGA	3.80e-03	44	39	2	IPR013785
Domain	Growth_fac_rcpt_	EPHB2 LAMC1 EPHB1	4.19e-03	156	39	3	IPR009030
Domain	ABC_TRANSPORTER_2	ABCB5 ABCB4	4.51e-03	48	39	2	PS50893
Domain	ABC_tran	ABCB5 ABCB4	4.51e-03	48	39	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCB5 ABCB4	4.70e-03	49	39	2	PS00211
Domain	ABC_transporter-like	ABCB5 ABCB4	4.89e-03	50	39	2	IPR003439
Domain	Kinase-like_dom	EPHB2 CSNK1A1L CSNK1A1 ROR2 EPHB1	5.15e-03	542	39	5	IPR011009
Domain	Glycoside_hydrolase_SF	SI NAGA	5.47e-03	53	39	2	IPR017853
Domain	Protein_kinase_ATP_BS	EPHB2 CSNK1A1L CSNK1A1 EPHB1	7.84e-03	379	39	4	IPR017441
Domain	SAM_1	EPHB2 EPHB1	8.87e-03	68	39	2	PF00536
Pathway	PID_WNT_NONCANONICAL_PATHWAY	TAB1 CSNK1A1 ROR2	6.06e-05	32	34	3	M23
Pubmed	Reelin induces EphB activation.	EPHB2 RELN EPHB1	3.03e-08	6	41	3	23318582
Pubmed	The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.	EPHB2 CSNK1A1L CSNK1A1	5.30e-08	7	41	3	17686994
Pubmed	Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	35695793
Pubmed	Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	23354688
Pubmed	Atmin modulates Pkhd1 expression and may mediate Autosomal Recessive Polycystic Kidney Disease (ARPKD) through altered non-canonical Wnt/Planar Cell Polarity (PCP) signalling.	PKHD1 ATMIN	1.36e-06	2	41	2	30414501
Pubmed	Exploring the role of casein kinase 1α splice variants across cancer cell lines.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	38852281
Pubmed	EphB2 receptor cell-autonomous forward signaling mediates auditory memory recall and learning-driven spinogenesis.	EPHB2 EPHB1	1.36e-06	2	41	2	31633063
Pubmed	Tissue-specific distribution of mouse casein kinase I alpha mRNA.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	9522121
Pubmed	Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	23690993
Pubmed	Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	25994086
Pubmed	CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	37723657
Pubmed	Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	36929849
Pubmed	Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	34216174
Pubmed	Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	37108197
Pubmed	Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.	CSNK1A1L CSNK1A1	1.36e-06	2	41	2	36542875
Pubmed	EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells.	EPHB2 ABCB4	1.36e-06	2	41	2	29416088
Pubmed	Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.	LAMC1 CTSL KLKB1 GNS	1.52e-06	71	41	4	12754519
Pubmed	EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.	EPHB2 EPHB1	4.06e-06	3	41	2	15722342
Pubmed	EphB receptors couple dendritic filopodia motility to synapse formation.	EPHB2 EPHB1	4.06e-06	3	41	2	18614029
Pubmed	Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase.	EPHB2 EPHB1	4.06e-06	3	41	2	29731254
Pubmed	Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.	CSNK1A1L CSNK1A1	4.06e-06	3	41	2	25242043
Pubmed	CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.	CSNK1A1L CSNK1A1	4.06e-06	3	41	2	28878021
Pubmed	Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.	EPHB2 EPHB1	4.06e-06	3	41	2	35025117
Pubmed	Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.	CSNK1A1L CSNK1A1	4.06e-06	3	41	2	26811327
Pubmed	Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.	CSNK1A1L CSNK1A1	4.06e-06	3	41	2	28655862
Pubmed	EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis.	EPHB2 EPHB1	4.06e-06	3	41	2	18057206
Pubmed	A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.	EPHB2 EPHB1	4.06e-06	3	41	2	23143520
Pubmed	Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.	EPHB2 EPHB1	4.06e-06	3	41	2	9499402
Pubmed	Completing the structural family portrait of the human EphB tyrosine kinase domains.	EPHB2 EPHB1	4.06e-06	3	41	2	24677421
Pubmed	Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.	CSNK1A1L CSNK1A1	4.06e-06	3	41	2	19805514
Pubmed	Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1.	EPHB2 EPHB1	4.06e-06	3	41	2	25051176
Pubmed	EphrinB1-EphB signaling regulates thymocyte-epithelium interactions involved in functional T cell development.	EPHB2 EPHB1	4.06e-06	3	41	2	17668899
Pubmed	Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation and Innate Fear.	EPHB2 EPHB1	4.06e-06	3	41	2	27683910
Pubmed	Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.	CSNK1A1L CSNK1A1	4.06e-06	3	41	2	24616378
Pubmed	Intracellular expression of P-170 glycoprotein in peripheral blood mononuclear cell subsets from healthy donors and HIV-infected patients.	ABCB5 ABCB4	4.06e-06	3	41	2	9542318
Pubmed	A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition.	EPHB2 EPHB1	4.06e-06	3	41	2	22622783
Pubmed	Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues.	EPHB2 EPHB1	4.06e-06	3	41	2	11532925
Pubmed	Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus.	EPHB2 EPHB1	4.06e-06	3	41	2	14691139
Pubmed	Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.	CSNK1A1L CSNK1A1	8.12e-06	4	41	2	38147624
Pubmed	EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak.	EPHB2 EPHB1	8.12e-06	4	41	2	23147113
Pubmed	Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis.	ITGA8 LAMC1	8.12e-06	4	41	2	15572035
Pubmed	Ephrin-B stimulation of calvarial bone formation.	EPHB2 EPHB1	8.12e-06	4	41	2	23129351
Pubmed	FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning.	CSNK1A1L CSNK1A1	8.12e-06	4	41	2	31338967
Pubmed	Cx43 phosphorylation sites regulate pancreatic cancer metastasis.	CSNK1A1L CSNK1A1	8.12e-06	4	41	2	33603164
Pubmed	The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.	CSNK1A1L CSNK1A1	8.12e-06	4	41	2	32728212
Pubmed	A neuronal molecular switch through cell-cell contact that regulates quiescent neural stem cells.	EPHB2 EPHB1	8.12e-06	4	41	2	30820459
Pubmed	Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization.	EPHB2 EPHB1	8.12e-06	4	41	2	26549443
Pubmed	FoxG1 Directly Represses Dentate Granule Cell Fate During Forebrain Development.	RELN EPHB1	8.12e-06	4	41	2	30532694
Pubmed	Regulation of p53-MDMX interaction by casein kinase 1 alpha.	CSNK1A1L CSNK1A1	8.12e-06	4	41	2	16024788
Pubmed	GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking.	EPHB2 EPHB1	8.12e-06	4	41	2	15965473
Pubmed	A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.	CSNK1A1L CSNK1A1	8.12e-06	4	41	2	30487124
Pubmed	A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses.	EPHB2 EPHB1	8.12e-06	4	41	2	21964490
Pubmed	Eph receptor deficiencies lead to altered cochlear function.	EPHB2 EPHB1	8.12e-06	4	41	2	12684184
Pubmed	Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors.	EPHB2 EPHB1	8.12e-06	4	41	2	22475621
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	EPHB2 LAMC1 OGFOD3 TYW1 FBXO22 CTSL GNS ROR2 NAGA	8.76e-06	1201	41	9	35696571
Pubmed	Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping.	EPHB2 EPHB1	1.35e-05	5	41	2	21847105
Pubmed	Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome.	CSNK1A1L CSNK1A1	1.35e-05	5	41	2	30651631
Pubmed	Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.	EPHB2 EPHB1	1.35e-05	5	41	2	8798570
Pubmed	Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice.	CSNK1A1L CSNK1A1	1.35e-05	5	41	2	30064974
Pubmed	Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex.	EPHB2 EPHB1	1.35e-05	5	41	2	21559471
Pubmed	A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.	CSNK1A1L CSNK1A1	1.35e-05	5	41	2	23890787
Pubmed	A critical function of the pial basement membrane in cortical histogenesis.	LAMC1 RELN	1.35e-05	5	41	2	12122064
Pubmed	CK1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3β pathway and inhibiting Foxa2 expression through p53 pathway†.	CSNK1A1L CSNK1A1	1.35e-05	5	41	2	37944068
Pubmed	Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification.	CSNK1A1L CSNK1A1	1.35e-05	5	41	2	36989576
Pubmed	Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.	CSNK1A1L CSNK1A1	1.35e-05	5	41	2	25628462
Pubmed	CKIα ablation highlights a critical role for p53 in invasiveness control.	CSNK1A1L CSNK1A1	1.35e-05	5	41	2	21331045
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	EPHB2 ROR2 EPHB1	1.46e-05	40	41	3	30898150
Pubmed	Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.	CSNK1A1L CSNK1A1	2.03e-05	6	41	2	15687492
Pubmed	EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure.	EPHB2 EPHB1	2.03e-05	6	41	2	26148571
Pubmed	Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.	CSNK1A1L CSNK1A1	2.03e-05	6	41	2	19118383
Pubmed	Ephrin-B/EphB Signaling Is Required for Normal Innervation of Lingual Gustatory Papillae.	EPHB2 EPHB1	2.03e-05	6	41	2	27035151
Pubmed	Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways.	CSNK1A1L CSNK1A1	2.03e-05	6	41	2	11884395
Pubmed	Physiological role for casein kinase 1 in glutamatergic synaptic transmission.	CSNK1A1L CSNK1A1	2.03e-05	6	41	2	16014721
Pubmed	Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord.	EPHB2 EPHB1	2.03e-05	6	41	2	16786562
Pubmed	Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning.	EPHB2 EPHB1	2.03e-05	6	41	2	19182796
Pubmed	MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling.	CSNK1A1L CSNK1A1	2.03e-05	6	41	2	32511789
Pubmed	Abnormal hippocampal axon bundling in EphB receptor mutant mice.	EPHB2 EPHB1	2.03e-05	6	41	2	15014111
Pubmed	MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.	CSNK1A1L CSNK1A1	2.03e-05	6	41	2	33667384
Pubmed	Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.	CSNK1A1L CSNK1A1	2.84e-05	7	41	2	25644602
Pubmed	Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain.	RELN EPHB1	2.84e-05	7	41	2	26269635
Pubmed	EphB regulates L1 phosphorylation during retinocollicular mapping.	EPHB2 EPHB1	2.84e-05	7	41	2	22579729
Pubmed	Forward signaling by EphB1/EphB2 interacting with ephrin-B ligands at the optic chiasm is required to form the ipsilateral projection.	EPHB2 EPHB1	2.84e-05	7	41	2	22103419
Pubmed	NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly.	CSNK1A1L CSNK1A1	2.84e-05	7	41	2	34615873
Pubmed	Similarities and Differences in the Way Transmembrane-Type Ligands Interact with the Elk Subclass of Eph Receptors.	EPHB2 EPHB1	2.84e-05	7	41	2	8954633
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	LAMC1 SI CTSL KLKB1 GNS ATP5F1A ABCB4 NAGA	3.03e-05	1070	41	8	23533145
Pubmed	Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.	CSNK1A1L CSNK1A1	3.78e-05	8	41	2	17244647
Pubmed	Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.	EPHB2 EPHB1	3.78e-05	8	41	2	14988728
Pubmed	Mis-expression of L1 on pre-crossing spinal commissural axons disrupts pathfinding at the ventral midline.	EPHB2 EPHB1	3.78e-05	8	41	2	17884558
Pubmed	EphB3 marks delaminating endocrine progenitor cells in the developing pancreas.	EPHB2 EPHB1	3.78e-05	8	41	2	22434763
Pubmed	Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin.	CSNK1A1L CSNK1A1	3.78e-05	8	41	2	17101137
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	CSNK1A1L CSNK1A1	3.78e-05	8	41	2	21930935
Pubmed	Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation.	EPHB2 EPHB1	3.78e-05	8	41	2	17310244
Pubmed	Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion.	EPHB2 EPHB1	4.86e-05	9	41	2	18713744
Pubmed	EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis.	EPHB2 EPHB1	4.86e-05	9	41	2	33253166
Pubmed	Effects of Fam83h truncation mutation on enamel developmental defects in male C57/BL6J mice.	CSNK1A1L CSNK1A1	4.86e-05	9	41	2	36272714
Pubmed	EphB/syndecan-2 signaling in dendritic spine morphogenesis.	EPHB2 EPHB1	4.86e-05	9	41	2	11580899
Pubmed	Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.	EPHB2 EPHB1	4.86e-05	9	41	2	11403717
Pubmed	Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.	CSNK1A1L CSNK1A1	4.86e-05	9	41	2	9601641
Pubmed	Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons.	EPHB2 EPHB1	4.86e-05	9	41	2	10704386
Pubmed	Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina.	EPHB2 EPHB1	4.86e-05	9	41	2	10683176
Cytoband	7p22.1	RSPH10B2 RSPH10B	8.20e-04	47	41	2	7p22.1
Cytoband	12q24.31	CFAP251 DNAH10	2.35e-03	80	41	2	12q24.31
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	TAB1 TCF20 NAGA	3.21e-03	330	41	3	chr22q13
GeneFamily	ATP binding cassette subfamily B	ABCB5 ABCB4	1.00e-04	11	25	2	806
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB2 EPHB1	1.65e-04	14	25	2	1095
GeneFamily	Sterile alpha motif domain containing	EPHB2 EPHB1	6.53e-03	88	25	2	760
GeneFamily	Fibronectin type III domain containing	EPHB2 EPHB1	2.04e-02	160	25	2	555
Coexpression	GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_DN	LAMC1 RBM47 CTSL ABCB4 NAGA	1.30e-05	200	40	5	M4612
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 ATP13A5 NALCN DNAH10 KLKB1	4.73e-07	169	41	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN NALCN KLKB1 PGM5 EPHB1	7.01e-07	183	41	5	764ea07621f77fbd13a877aed5806ae2b3dfb43e
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN NALCN KLKB1 PGM5 EPHB1	7.01e-07	183	41	5	38a54216458ad57f356bb4ddf272e1af8036ddeb
ToppCell	wk_20-22-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RELN NALCN CTSL PGM5 EPHB1	8.44e-07	190	41	5	103e78c2233c3ee0c215a9dafe70705477e9ee5e
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN NALCN CTSL KLKB1 PGM5	8.89e-07	192	41	5	5388f3115ab285f3f3001af1d71543ed64b9e044
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN NALCN CTSL KLKB1 PGM5	9.12e-07	193	41	5	ef007b736da56529ec628fc3df86a335e7ec3f18
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN NALCN PGM5 EPHB1	1.44e-05	161	41	4	fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN NALCN PGM5 EPHB1	1.44e-05	161	41	4	c53c461fc721a7960cef86662f49e2a495520701
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKHD1 ATP13A5 DNAH10 KLKB1	1.48e-05	162	41	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHB2 RELN KLKB1 PGM5	1.91e-05	173	41	4	85083b9ce20351dd69aa2327ad087b848b4307ff
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RELN NALCN KLKB1 EPHB1	2.19e-05	179	41	4	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RELN NALCN KLKB1 EPHB1	2.19e-05	179	41	4	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN CTSL KLKB1 PGM5	2.38e-05	183	41	4	a90ffd9c50caa65f537a2e441e37655e1b622327
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN CTSL KLKB1 PGM5	2.38e-05	183	41	4	13ad20ec140ef5b96fdace3369b5befc0f40bb76
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RELN NALCN PGM5 EPHB1	2.49e-05	185	41	4	f9f48251bc33eb6bf2cff580d1a3207d21450aa0
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RELN NALCN PGM5 EPHB1	2.71e-05	189	41	4	0d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RELN NALCN PGM5 EPHB1	2.71e-05	189	41	4	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LAMC1 RELN NALCN PGM5	2.76e-05	190	41	4	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	wk_20-22-Endothelial-Lymph_endothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RELN KLKB1 PGM5 EPHB1	2.82e-05	191	41	4	631f95fd80dd3678b5b2ef201abf7fe646049af6
ToppCell	wk_20-22-Endothelial-Lymph_endothelial-Lymphatic_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RELN KLKB1 PGM5 EPHB1	3.00e-05	194	41	4	640ff8da7084a9486fc2752493b8d8059ecf4ab7
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN NALCN RSPH10B PGM5	3.06e-05	195	41	4	590c0dc0db4dc62879645ed7f61292ff97d2c7d5
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	RELN CFAP251 CTSL PGM5	3.12e-05	196	41	4	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	10x5'v1-week_12-13-Hematopoietic-erythroid-mid_erythroid\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SLC6A9 RELN ZDHHC17 CTSL	3.18e-05	197	41	4	d8f99a9f2367c8bc9308b0c64d0226875262927a
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated-Deuterosomal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RSPH10B2 CFAP251 DNAH10 RSPH10B	3.24e-05	198	41	4	f31790442ef142f1c0c49bf3daf2d0efb193d2c9
ToppCell	Monocytes-Phagocytic_CD16+_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	EPHB2 RBM47 CTSL GNS	3.24e-05	198	41	4	09009cc966bf1503c3b15dfa079a6c5f6ad1f507
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CIDEB SI RBM47 GNS	3.31e-05	199	41	4	f26c20f5d7470e90eaa79613d0b87bd4865585a8
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Pleural_Mac\|normal_Pleural_Fluid / Location, Cell class and cell subclass	RBM47 CTSL GNS NAGA	3.37e-05	200	41	4	1798eb621dccb4ccae18d9b3df558a6428d30542
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	RSPH10B2 CFAP251 DNAH10 RSPH10B	3.37e-05	200	41	4	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RSPH10B2 CFAP251 DNAH10 RSPH10B	3.37e-05	200	41	4	73ac1cf40ddd764be1100cbfaaa29563665457d8
ToppCell	LPS-IL1RA-Epithelial_alveolar-Mes-Like-AT1_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PKHD1 SI TKTL1	1.70e-04	117	41	3	f3c77b234e461566aac81ede0ef84008c9a9f51e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CTSL ROR2 NTSR1	3.26e-04	146	41	3	1e81ad3d6d5d5ad2f0176d2a9593a954d38fa294
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	EPHB2 ABCB5 ABCB4	3.46e-04	149	41	3	a6c24d8f3b5f08587f0a12cd63d166b68ea000c7
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RBM47 ATP5F1A RSPH10B	3.74e-04	153	41	3	0307f10e772021ae68a42690634df458672a6df9
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CTSL ABCB5 ABCB4	4.18e-04	159	41	3	d9e535cf9a0a2302268f2897b010dcecc6426e41
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CTSL ABCB5 ABCB4	4.18e-04	159	41	3	29999c87f5823f734e5cbf8ea8b729ec017db9b3
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CTSL ABCB5 ABCB4	4.18e-04	159	41	3	4b840da854390f8285c219314cff4434d7ffcacc
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 ATP13A5 DNAH10	4.26e-04	160	41	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 ATP13A5 DNAH10	4.26e-04	160	41	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 KLKB1 ABCB4	4.26e-04	160	41	3	c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TKTL1 GNS NAGA	4.34e-04	161	41	3	5cb91ae9674b370a27be0d5852c3816b4434239e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN NALCN PGM5	4.42e-04	162	41	3	2ac02523348660e514d464f8f2434ee0c312d784
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D231\|Adult / Lineage, Cell type, age group and donor	ITGA8 NALCN ROR2	4.58e-04	164	41	3	3d8ff70fe5582d1fb56b338be8b76fa1428b3657
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intermediate_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	EPHB2 RBM47 CTSL	4.66e-04	165	41	3	c3fa9225d2f9c9e821d4fbd2315fcc98ce1f1c55
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ITGA8 RELN EPHB1	4.74e-04	166	41	3	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|356C / Donor, Lineage, Cell class and subclass (all cells)	RELN PGM5 EPHB1	4.74e-04	166	41	3	6bd5aa205b6e4b88ba9f8cd0999e2191d7d1d16c
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	RELN PGM5 EPHB1	4.74e-04	166	41	3	5ba45407a47207ff01e4a3f9f5d91d8247fe9b6f
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	ITGA8 RELN EPHB1	4.74e-04	166	41	3	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN NALCN CTSL	4.74e-04	166	41	3	941d6aa94ab9d36e5f6c40f446c926754e070d56
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN NALCN CTSL	4.74e-04	166	41	3	6f5ecf3b2cf613ae0535ab3d21d93622f1497571
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	ITGA8 NALCN ROR2	4.83e-04	167	41	3	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 KLKB1 ABCB4	4.91e-04	168	41	3	b98af4043dfa5dfa4413e482879fad88de484675
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP251 DNAH10 RSPH10B	4.91e-04	168	41	3	fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP251 DNAH10 RSPH10B	4.91e-04	168	41	3	7edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 KLKB1 ABCB4	4.91e-04	168	41	3	073b53d4cee6bc8c5c6fce51cf6cd9c316478f69
ToppCell	Endothelial-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	RELN PGM5 EPHB1	5.00e-04	169	41	3	95c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCell	droplet-Liver-HEPATOCYTES\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 KLKB1 ABCB4	5.00e-04	169	41	3	f195467438c589f87224bde7da720dea072d110c
ToppCell	droplet-Liver-HEPATOCYTES-1m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 KLKB1 ABCB4	5.00e-04	169	41	3	7785cab967a33560830c394c918d6ce625103858
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_PENK\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ROR2 NTSR1	5.00e-04	169	41	3	eb3b8e473192c4b8688f2f8da400116dd6fe193d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN PGM5 EPHB1	5.08e-04	170	41	3	dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN PGM5 EPHB1	5.08e-04	170	41	3	6035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN PGM5 EPHB1	5.08e-04	170	41	3	c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCell	droplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA8 RELN RBM47	5.08e-04	170	41	3	29deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCell	droplet-Thymus-nan-21m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA8 RELN RBM47	5.08e-04	170	41	3	dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN NALCN PGM5	5.35e-04	173	41	3	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RELN RSPH10B PGM5	5.53e-04	175	41	3	9a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RELN RSPH10B PGM5	5.53e-04	175	41	3	54c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN KLKB1 PGM5	5.53e-04	175	41	3	43be63976da5ad0764d24d90919a77ce46068f52
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN DNAH10 PGM5	5.53e-04	175	41	3	f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 KLKB1 ABCB4	5.53e-04	175	41	3	5c38d4b6c03473d841e6203a7efaa6dcb2d59386
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RELN RSPH10B PGM5	5.53e-04	175	41	3	2b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	RELN PGM5 EPHB1	5.62e-04	176	41	3	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	Ciliated_cells-A-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	RSPH10B2 CFAP251 DNAH10	5.62e-04	176	41	3	1c364155f46b9a7c995bdc2cc2333c437cd90f5b
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	CFAP251 DNAH10 NAGA	5.62e-04	176	41	3	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	RELN PGM5 EPHB1	5.62e-04	176	41	3	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN NALCN PGM5	5.72e-04	177	41	3	c274fbdc141855ff4581d437d4997c64cc193278
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN NALCN PGM5	5.72e-04	177	41	3	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN NALCN PGM5	5.72e-04	177	41	3	c8a51e480b978dc0ded85583261f2c892e085be8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN NALCN PGM5	5.72e-04	177	41	3	f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCell	15-Airway-Epithelial-Multiciliated_precursor\|Airway / Age, Tissue, Lineage and Cell class	RSPH10B2 CFAP251 DNAH10	5.81e-04	178	41	3	d8e0a696bdd6af6422d72af0413f9dbd6bc02afa
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN KLKB1 EPHB1	5.91e-04	179	41	3	abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN KLKB1 EPHB1	5.91e-04	179	41	3	0b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TKTL1 CTSL GNS	5.91e-04	179	41	3	6624a2e731ab2d6c2eec19445e3dc509f581a8a9
ToppCell	367C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ITGA8 TAB1 GNS	5.91e-04	179	41	3	5aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	EPHB2 CTSL NAGA	6.00e-04	180	41	3	b94618c1c2592ecf7da3535294aee9243755247a
ToppCell	facs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 RBM47 CTSL	6.00e-04	180	41	3	bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCell	facs-Marrow-B-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 RBM47 CTSL	6.00e-04	180	41	3	839defb40f7cfb2711e9025194de636533f51bcd
ToppCell	facs-Marrow-B-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 RBM47 CTSL	6.00e-04	180	41	3	82965ed1b72a1873c24dd4553d39681596057316
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ITGA8 NALCN ROR2	6.00e-04	180	41	3	01f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Ciliated\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFAP251 DNAH10 RSPH10B	6.10e-04	181	41	3	8eed9d46d924b16f6dd1a025ff612244b02b4391
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ITGA8 PGM5 ROR2	6.10e-04	181	41	3	9b2d207dc9fc2228a1555ed360286bb7c2d988ff
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RSPH10B2 CFAP251 DNAH10	6.10e-04	181	41	3	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMC1 RELN EPHB1	6.20e-04	182	41	3	0cde2775bdaaa2172499925bd59b0ac2d545eb27
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMC1 RELN EPHB1	6.20e-04	182	41	3	2cc434e46985c66fc36de05344a67aa96d90abc9
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RELN ZDHHC17 PGM5	6.20e-04	182	41	3	53c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMC1 RELN EPHB1	6.20e-04	182	41	3	3e7457b2a70b45735fb75d6617b7f34cef28758e
ToppCell	P03-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN PGM5 EPHB1	6.30e-04	183	41	3	89727b4f65949ed2dce9d2e0228c79fe4280230c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RBM47 CTSL GNS	6.30e-04	183	41	3	745271bfe15e94a58157cd97d771e610f964341b
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RELN NALCN PGM5	6.30e-04	183	41	3	bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 RELN DNAH10	6.30e-04	183	41	3	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	P03-Endothelial-lymphatic_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN PGM5 EPHB1	6.30e-04	183	41	3	113e6d8d4bb271be984af06cd6c22b180425dcfc
Computational	Genes in the cancer module 85.	EPHB2 ROR2 EPHB1	3.03e-04	51	28	3	MODULE_85
Computational	Genes in the cancer module 199.	EPHB2 ROR2 EPHB1	4.22e-04	57	28	3	MODULE_199
Drug	Troleandomycin [2751-09-9]; Down 200; 5uM; PC3; HT_HG-U133A	EPHB2 CIDEB SLC6A9 TAB1 ZDHHC17 NTSR1	9.71e-07	196	39	6	3985_DN
Drug	AC1Q5W8U	CSNK1A1L CSNK1A1 ATP5F1A	2.08e-06	15	39	3	CID000006483
Drug	Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; MCF7; HT_HG-U133A	RELN OGFOD3 TAB1 ZDHHC17 GNS	2.09e-05	197	39	5	7177_UP
Drug	Memantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; PC3; HT_HG-U133A	EPHB2 CIDEB SLC6A9 TAB1 NTSR1	2.09e-05	197	39	5	4017_DN
Drug	IC261	CSNK1A1L DNAH10 CSNK1A1 ABCB4	2.18e-05	96	39	4	CID000003674
Drug	AC1L2MCS	ABCB5 ABCB4	2.85e-05	5	39	2	CID000023441
Drug	beryllium fluoride	PPP4C ATP5F1A ABCB5 ABCB4	2.88e-05	103	39	4	CID000024589
Drug	v 104	ABCB5 ABCB4	4.27e-05	6	39	2	CID000107262
Drug	AC1L99H3	ABCB5 ABCB4	4.27e-05	6	39	2	CID000440540
Drug	tBCEU	ABCB5 ABCB4	7.95e-05	8	39	2	CID000164059
Drug	nicotine glucuronide	ABCB5 ABCB4	7.95e-05	8	39	2	CID003035848
Drug	iodoarylazidoprazosin	ABCB5 ABCB4	7.95e-05	8	39	2	CID000115344
Drug	tXMP	ABCB5 ABCB4	7.95e-05	8	39	2	CID003081384
Drug	So324	ABCB5 ABCB4	1.02e-04	9	39	2	CID000462261
Drug	Emd 51921	ABCB5 ABCB4	1.28e-04	10	39	2	CID000164353
Drug	di-t-butylphosphite	CSNK1A1L CSNK1A1	1.28e-04	10	39	2	CID000518693
Drug	2-amino-5-(N-ethylcarboxyamido)-pentanoic acid	CSNK1A1L CSNK1A1	1.28e-04	10	39	2	CID000194789
Drug	diC4PC	ABCB5 ABCB4	1.28e-04	10	39	2	CID000193375
Drug	CKI-8	CSNK1A1L CSNK1A1	1.28e-04	10	39	2	CID000486026
Drug	Asptpsa	CSNK1A1L CSNK1A1	1.28e-04	10	39	2	CID000132853
Drug	AC1MZ4R5	ABCB5 ABCB4	1.28e-04	10	39	2	CID003842392
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1A1L CSNK1A1	3.75e-05	7	40	2	DOID:0060807 (implicated_via_orthology)
Disease	cystic fibrosis (implicated_via_orthology)	ABCB5 ABCB4	6.41e-05	9	40	2	DOID:1485 (implicated_via_orthology)
Disease	Tourette syndrome, schizophrenia	TCF20 DNAH10	2.70e-04	18	40	2	EFO_0004895, MONDO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
ACLGVMGFFYALGVY	ATP13A5	406	Q4VNC0
LGAVYFFMNGTYGLA	ABCB5	291	Q2M3G0
CFVSYFMQGLFYGRA	ABCB5	746	Q2M3G0
FCSFGSRLMGRGYYV	ATXN7L1	466	Q9ULK2
YSGCSMGEYFRDNGK	ATP5F1A	291	P25705
GMAVSYDGCYAFTAG	CFAP251	896	Q8TBY9
FDGKNRGYAFVMYCH	RBM47	106	A0AV96
YGFGAAFDADGDRYM	PGM5	286	Q15124
AAFQGGCTYRGMFSE	RSPH10B	101	P0C881
AAFQGGCTYRGMFSE	RSPH10B2	101	B2RC85
NGFYLAFQDYGACMS	EPHB1	171	P54762
GFMFACVGRGFQYYR	FBXO22	321	Q8NEZ5
YLSNYLEDFGGGRFM	OGFOD3	246	Q6PK18
GCGTQMYFFFFFGSS	OR10A7	96	Q8NGE5
FGDAGCRGYYFLRDA	NTSR1	136	P30989
RSGFYLAFQDYGGCM	EPHB2	171	P29323
GFPAEFAMYLNYCRG	CSNK1A1L	251	Q8N752
GQGYCQAGFSLDFYK	ITGA8	196	P53708
YGNLRFYFVMGGICD	RELN	471	P78509
AFMYFSYAGCFRFGA	ABCB4	946	P21439
YGCRGNSNFLGLEMF	ATMIN	686	O43313
LRSMCGYQTFFAGKY	GNS	136	P15586
YENAFFRGGDVASMY	KLKB1	26	P03952
YGGQFCEMCLSGYRR	LAMC1	696	P11047
CFYGGTPYGGQFERM	DDX21	291	Q9NR30
RQCTGTFGYGYEYMG	DNAH10	1786	Q8IVF4
NCFLYGVFNGYDGNR	TAB1	61	Q15750
GFPAEFAMYLNYCRG	CSNK1A1	251	P48729
VCGAGYGYFFHLMTN	PKHD1	2336	P08F94
FGMSYTGADICGFFN	SI	1521	P14410
GRYHQCYNGSGMDYR	ROR2	311	Q01974
EGCNGGLMDYAFQYV	CTSL	176	P07711
FYGLYSMSCDFQGLG	CIDEB	156	Q9UHD4
FPYLCYRNGGGAFMF	SLC6A9	126	P48067
GFRKEAGDFYYMAGN	TCF20	81	Q9UGU0
GNCVGAGNHRYFMGY	ZDHHC17	471	Q8IUH5
LCYVGFYFLGAGLME	TRBV25-1	6	A0A075B6N4
GMRYAVFGLGNSAYA	TYW1	171	Q9NV66
NYLFMGDFVDRGFYS	PPP4C	76	P60510
GVACGMAYTGKYFDR	TKTL1	101	P51854
DCGNYAGALMYFCSF	NALCN	1416	Q8IZF0
LGIYADMGNFTCMGY	NAGA	116	P17050