Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

MICAL1 MICAL3 MICAL2

3.55e-0540323GO:0016709
GeneOntologyMolecularFunctionFAD binding

MICAL1 MICAL3 MICAL2

4.73e-0544323GO:0071949
GeneOntologyMolecularFunctionNAD(P)H oxidase H2O2-forming activity

MICAL1 MICAL2

1.63e-0412322GO:0016174
GeneOntologyMolecularFunctionphosphoserine residue binding

YWHAB YWHAE

1.63e-0412322GO:0050815
GeneOntologyMolecularFunctionflavin adenine dinucleotide binding

MICAL1 MICAL3 MICAL2

4.54e-0494323GO:0050660
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

MICAL1 MICAL2

4.64e-0420322GO:0050664
GeneOntologyMolecularFunctionmonooxygenase activity

MICAL1 MICAL3 MICAL2

8.17e-04115323GO:0004497
GeneOntologyMolecularFunctionMHC class II protein complex binding

YWHAE ANXA11

8.52e-0427322GO:0023026
GeneOntologyMolecularFunctionactin binding

MICAL1 MICAL3 NEB MICAL2 SPTBN2

9.17e-04479325GO:0003779
GeneOntologyMolecularFunctionMHC protein complex binding

YWHAE ANXA11

1.96e-0341322GO:0023023
GeneOntologyBiologicalProcesssulfur oxidation

MICAL1 MICAL2

2.33e-062322GO:0019417
GeneOntologyBiologicalProcessactin filament depolymerization

MICAL1 MICAL3 MICAL2 SPTBN2

3.21e-0666324GO:0030042
GeneOntologyBiologicalProcessprotein depolymerization

MICAL1 MICAL3 MICAL2 SPTBN2

7.04e-05144324GO:0051261
GeneOntologyBiologicalProcesscalcium ion export across plasma membrane

SLC8A3 YWHAE

1.52e-0412322GO:1990034
DomainFAD_binding_3

MICAL1 MICAL3 MICAL2

8.25e-086313PF01494
DomainFAD-bd

MICAL1 MICAL3 MICAL2

8.25e-086313IPR002938
DomainKRAB_RELATED

SSX8P SSX1 SSX2

6.77e-0711313PS50806
DomainKrueppel-associated_box-rel

SSX8P SSX1 SSX2

1.17e-0613313IPR003655
DomainCH

MICAL1 MICAL3 MICAL2 SPTBN2

3.92e-0665314SM00033
DomainCH

MICAL1 MICAL3 MICAL2 SPTBN2

5.27e-0670314PF00307
Domain-

MICAL1 MICAL3 MICAL2 SPTBN2

5.58e-06713141.10.418.10
DomainCH

MICAL1 MICAL3 MICAL2 SPTBN2

6.24e-0673314PS50021
DomainCH-domain

MICAL1 MICAL3 MICAL2 SPTBN2

6.95e-0675314IPR001715
DomainSSX

SSX1 SSX2

3.98e-056312IPR028804
Domain14_3_3

YWHAB YWHAE

5.57e-057312SM00101
Domain1433_1

YWHAB YWHAE

5.57e-057312PS00796
Domain1433_2

YWHAB YWHAE

5.57e-057312PS00797
DomainDUF3585

MICAL1 MICAL3

5.57e-057312PF12130
Domain14-3-3_domain

YWHAB YWHAE

5.57e-057312IPR023410
Domain14-3-3_CS

YWHAB YWHAE

5.57e-057312IPR023409
Domain14-3-3

YWHAB YWHAE

5.57e-057312PF00244
DomainDUF3585

MICAL1 MICAL3

5.57e-057312IPR022735
Domain14-3-3

YWHAB YWHAE

7.42e-058312IPR000308
DomainSSXRD

SSX1 SSX2

7.42e-058312PF09514
DomainSSXRD_motif

SSX1 SSX2

7.42e-058312IPR019041
Domain-

MICAL1 MICAL3 MICAL2

1.08e-04563133.50.50.60
DomainFAD/NAD-binding_dom

MICAL1 MICAL3 MICAL2

1.14e-0457313IPR023753
DomainLIM

MICAL1 MICAL3 MICAL2

2.01e-0469313PF00412
Domain-

MICAL1 MICAL3 MICAL2

2.10e-04703132.10.110.10
DomainLIM_DOMAIN_2

MICAL1 MICAL3 MICAL2

2.19e-0471313PS50023
DomainZnf_LIM

MICAL1 MICAL3 MICAL2

2.19e-0471313IPR001781
DomainLIM_DOMAIN_1

MICAL1 MICAL3 MICAL2

2.19e-0471313PS00478
DomainLIM

MICAL1 MICAL3 MICAL2

2.19e-0471313SM00132
DomainKRAB

SSX8P SSX1 SSX2 ZNF445

2.77e-03358314PF01352
DomainKRAB

SSX8P SSX1 SSX2 ZNF445

3.09e-03369314SM00349
DomainKRAB

SSX8P SSX1 SSX2 ZNF445

3.12e-03370314IPR001909
DomainIg_E-set

ASCC3 KCNJ4

1.29e-02104312IPR014756
PathwayPID_PI3KCI_AKT_PATHWAY

YWHAB YWHAE CHUK

1.32e-0535193M249
PathwayPID_FOXO_PATHWAY

YWHAB YWHAE CHUK

3.68e-0549193M136
PathwayKEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION

ATP6V1A MAP2K4 CHUK

9.84e-0568193M16848
PathwayREACTOME_SARS_COV_2_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS

YWHAB YWHAE

1.13e-0412192M45022
PathwayREACTOME_CHK1_CHK2_CDS1_MEDIATED_INACTIVATION_OF_CYCLIN_B_CDK1_COMPLEX

YWHAB YWHAE

1.13e-0412192MM15443
PathwayREACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA

YWHAB YWHAE

1.13e-0412192MM14482
PathwayKEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY

YWHAB YWHAE

1.33e-0413192M47589
PathwayREACTOME_CHK1_CHK2_CDS1_MEDIATED_INACTIVATION_OF_CYCLIN_B_CDK1_COMPLEX

YWHAB YWHAE

1.33e-0413192M27708
PathwayREACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA

YWHAB YWHAE

1.79e-0415192M26902
PathwayREACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION

MAP2K4 CHUK

2.04e-0416192M27567
PathwayREACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS

YWHAB YWHAE

2.04e-0416192M46428
PathwayWP_VEGFAVEGFR2_SIGNALING

MAP2K4 ASCC3 YWHAE MICAL2 RPL7

2.13e-04431195M39729
PathwayREACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS

YWHAB YWHAE

2.60e-0418192MM14510
PathwayREACTOME_SIGNALING_BY_HIPPO

YWHAB YWHAE

3.22e-0420192MM14813
PathwayREACTOME_SIGNALING_BY_HIPPO

YWHAB YWHAE

3.22e-0420192M591
PathwayWP_17P133_YWHAE_COPY_NUMBER_VARIATION

YWHAB YWHAE

3.56e-0421192M48088
PathwayPID_P38_MK2_PATHWAY

YWHAB YWHAE

3.56e-0421192M199
PathwayPID_ERBB1_DOWNSTREAM_PATHWAY

MAP2K4 YWHAB YWHAE

3.57e-04105193M164
PathwayREACTOME_RHO_GTPASES_ACTIVATE_PKNS

YWHAB YWHAE

4.28e-0423192MM15216
PathwayBIOCARTA_TOLL_PATHWAY

MAP2K4 CHUK

4.67e-0424192MM1518
PathwayBIOCARTA_STRESS_PATHWAY

MAP2K4 CHUK

4.67e-0424192MM1515
PathwayBIOCARTA_STRESS_PATHWAY

MAP2K4 CHUK

4.67e-0424192M9670
PathwayBIOCARTA_TOLL_PATHWAY

MAP2K4 CHUK

5.07e-0425192M984
PathwayPID_INSULIN_GLUCOSE_PATHWAY

YWHAB YWHAE

5.49e-0426192M247
PathwayPID_TRAIL_PATHWAY

MAP2K4 CHUK

6.37e-0428192M79
PathwayPID_PDGFRB_PATHWAY

MAP2K4 YWHAB YWHAE

6.52e-04129193M186
PathwayREACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS

YWHAB YWHAE

7.32e-0430192M17814
PathwayPID_HDAC_CLASSII_PATHWAY

YWHAB YWHAE

9.41e-0434192M30
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

SLC8A3 YWHAB YWHAE

9.52e-04147193MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

SLC8A3 YWHAB YWHAE

1.03e-03151193M39329
PathwayWP_HEPATITIS_B_INFECTION

MAP2K4 YWHAB CHUK

1.03e-03151193M39801
PathwayPID_PI3K_PLC_TRK_PATHWAY

YWHAB YWHAE

1.06e-0336192M271
PathwayWP_PDGF_PATHWAY

MAP2K4 CHUK

1.30e-0340192M39555
PathwayREACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS

YWHAB YWHAE

1.30e-0340192MM14473
PathwayREACTOME_MUSCLE_CONTRACTION

SLC8A3 NEB KCNJ4

1.33e-03165193MM15026
PathwayBIOCARTA_KERATINOCYTE_PATHWAY

MAP2K4 CHUK

1.72e-0346192MM1428
PathwayPID_A6B1_A6B4_INTEGRIN_PATHWAY

YWHAB YWHAE

1.72e-0346192M239
PathwayBIOCARTA_KERATINOCYTE_PATHWAY

MAP2K4 CHUK

1.72e-0346192M19118
PathwayPID_LKB1_PATHWAY

YWHAB YWHAE

1.79e-0347192M87
PathwayWP_INTERLEUKIN1_IL1_STRUCTURAL_PATHWAY

MAP2K4 CHUK

1.95e-0349192M39543
PathwaySIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES

YWHAB YWHAE

2.11e-0351192M7955
PathwayPID_NFAT_3PATHWAY

YWHAB YWHAE

2.28e-0353192M113
PathwayREACTOME_MUSCLE_CONTRACTION

SLC8A3 NEB KCNJ4

2.40e-03203193M5485
PathwayREACTOME_SARS_COV_2_HOST_INTERACTIONS

YWHAB YWHAE CHUK

2.44e-03204193M45011
PathwayWP_IL1_SIGNALING

MAP2K4 CHUK

2.45e-0355192M39346
PathwayWP_CARDIAC_HYPERTROPHIC_RESPONSE

MAP2K4 CHUK

2.45e-0355192M39685
PathwayREACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS

YWHAB YWHAE

2.45e-0355192M7455
PathwayREACTOME_INTERLEUKIN_17_SIGNALING

MAP2K4 CHUK

2.81e-0359192MM15128
PathwayPID_FCER1_PATHWAY

MAP2K4 CHUK

2.91e-0360192M7
PathwayWP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY

YWHAB YWHAE

3.51e-0366192MM15925
PathwaySIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES

YWHAB YWHAE

3.61e-0367192M295
PathwayPID_P75_NTR_PATHWAY

YWHAE CHUK

3.72e-0368192M153
PathwayPID_MTOR_4PATHWAY

YWHAB YWHAE

3.83e-0369192M121
PathwayREACTOME_CELLULAR_RESPONSES_TO_STIMULI

ATP6V1A MAP2K4 TALDO1 YWHAE RPL7

4.02e-03828195M27827
PathwayREACTOME_INTERLEUKIN_17_SIGNALING

MAP2K4 CHUK

4.05e-0371192M27382
PathwayREACTOME_G2_M_DNA_DAMAGE_CHECKPOINT

YWHAB YWHAE

4.16e-0372192MM15381
PathwayREACTOME_TRANSLOCATION_OF_SLC2A4_GLUT4_TO_THE_PLASMA_MEMBRANE

YWHAB YWHAE

4.16e-0372192M26954
PathwayREACTOME_TP53_REGULATES_METABOLIC_GENES

YWHAB YWHAE

4.27e-0373192MM15223
Pubmed

Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.

MICAL1 MICAL3 MICAL2

2.83e-09432324440334
Pubmed

The MICAL proteins and rab1: a possible link to the cytoskeleton?

MICAL1 MICAL3 MICAL2

2.83e-09432315694364
Pubmed

MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.

MICAL1 MICAL3 MICAL2

7.07e-09532312110185
Pubmed

Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.

SLC8A3 YWHAB YWHAE

2.47e-08732316679322
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ATP6V1A MICAL1 MAP2K4 MICAL3 C12orf50 YWHAB YWHAE MICAL2 RPL7 SPTBN2

3.79e-071431321037142655
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

UBR1 ATP6V1A MICAL1 MAP2K4 GDF9 YWHAB YWHAE RPL7 HMGXB4

5.34e-07112432921900206
Pubmed

Molecular diagnosis of synovial sarcoma: RT-PCR detection of SYT-SSX1/2 fusion transcripts in paraffin-embedded tissue.

SSX1 SSX2

8.20e-07232215735574
Pubmed

The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3β and ε are independent prognostic factors for these tumors.

YWHAB YWHAE

8.20e-07232221935479
Pubmed

[Analysis of SYT/SSX1 and SYT/SSX2 fusion genes from synovial sarcoma].

SSX1 SSX2

8.20e-07232222393780
Pubmed

Differential regulation of actin microfilaments by human MICAL proteins.

MICAL1 MICAL2

8.20e-07232222331357
Pubmed

A novel fluorescence in situ hybridization assay for synovial sarcoma.

SSX1 SSX2

8.20e-07232223623359
Pubmed

The SSX gene family: characterization of 9 complete genes.

SSX8P SSX1 SSX2

9.30e-072132312216073
Pubmed

14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.

YWHAB YWHAE

2.46e-06332214679215
Pubmed

Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation.

YWHAB YWHAE

2.46e-06332223615913
Pubmed

Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein.

SSX1 SSX2

2.46e-06332224130893
Pubmed

Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.

SSX1 SSX2

2.46e-0633227539744
Pubmed

Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas.

SSX1 SSX2

2.46e-0633227655467
Pubmed

Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma.

SSX1 SSX2

2.46e-06332216152617
Pubmed

Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases.

SSX1 SSX2

2.46e-06332222976541
Pubmed

SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma.

SSX1 SSX2

2.46e-06332224166495
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

ATP6V1A ASCC3 YWHAB YWHAE RPL7 ANXA11

4.69e-0648432631995728
Pubmed

Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas.

SSX1 SSX2

4.92e-06432212037676
Pubmed

HIV-1 Vpr induces G2 cell cycle arrest in fission yeast associated with Rad24/14-3-3-dependent, Chk1/Cds1-independent Wee1 upregulation.

YWHAB YWHAE

4.92e-06432216968670
Pubmed

Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo.

YWHAB YWHAE

4.92e-06432212507503
Pubmed

Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma.

SSX1 SSX2

4.92e-0643227951320
Pubmed

Binding of 14-3-3beta but not 14-3-3sigma controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B.

YWHAB YWHAE

4.92e-06432215173315
Pubmed

Cleavage of 14-3-3 protein by caspase-3 facilitates bad interaction with Bcl-x(L) during apoptosis.

YWHAB YWHAE

4.92e-06432212657644
Pubmed

The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

YWHAB YWHAE

4.92e-06432211784866
Pubmed

Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex.

YWHAB YWHAE

4.92e-06432215229649
Pubmed

Interaction of 14-3-3 with Bid during seizure-induced neuronal death.

YWHAB YWHAE

4.92e-06432212871587
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

AGAP7P NEB YWHAB YWHAE RPL7 CHUK

6.54e-0651332625798074
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

ATP6V1A MICAL3 ASCC3 TALDO1 YWHAB YWHAE RPL7 SPTBN2

7.19e-06114932835446349
Pubmed

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.

YWHAB YWHAE

8.19e-06532216227609
Pubmed

Structural basis for protein-protein interactions in the 14-3-3 protein family.

YWHAB YWHAE

8.19e-06532217085597
Pubmed

RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain.

YWHAB YWHAE

8.19e-06532211985497
Pubmed

An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel.

YWHAB YWHAE

8.19e-06532218687683
Pubmed

Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein.

TALDO1 RPL7

8.19e-06532225854864
Pubmed

A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection.

YWHAB YWHAE

8.19e-06532223938468
Pubmed

A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins.

YWHAB YWHAE

8.19e-06532216775625
Pubmed

Isoform-specific cleavage of 14-3-3 proteins in apoptotic JURL-MK1 cells.

YWHAB YWHAE

8.19e-06532219173300
Pubmed

MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.

MICAL1 MICAL2

8.19e-06532223911929
Pubmed

14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks.

YWHAB YWHAE

8.19e-06532221533173
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

ATP6V1A TALDO1 YWHAB YWHAE RPL7 ANXA11 SPTBN2

9.81e-0684732735235311
Pubmed

Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.

YWHAB YWHAE

1.23e-05632225588844
Pubmed

The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.

SSX1 SSX2

1.23e-05632226947017
Pubmed

14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels.

YWHAB YWHAE

1.23e-05632216613846
Pubmed

Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11.

YWHAB YWHAE

1.23e-0563229369453
Pubmed

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins.

YWHAB YWHAE

1.23e-05632210407019
Pubmed

14-3-3 proteins associate with cdc25 phosphatases.

YWHAB YWHAE

1.23e-0563227644510
Pubmed

Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.

YWHAB YWHAE

1.23e-05632210644344
Pubmed

Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase.

YWHAB YWHAE

1.23e-05632210713667
Pubmed

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.

YWHAB YWHAE

1.23e-05632210681541
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

YWHAB YWHAE RPL7 SPTBN2 LRP2BP

1.27e-0533332532665550
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

UBR1 ATP6V1A ASCC3 TALDO1 YWHAB YWHAE MICAL2 RPL7

1.30e-05124732827684187
Pubmed

Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins.

YWHAB YWHAE

1.72e-05732210441394
Pubmed

14-3-3 and erlin proteins differentially interact with RIPK2 complexes.

YWHAB YWHAE

1.72e-05732234152391
Pubmed

Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.

YWHAB YWHAE

1.72e-05732215023544
Pubmed

Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes.

YWHAB YWHAE

1.72e-05732217369396
Pubmed

The expression of seven 14-3-3 isoforms in human meningioma.

YWHAB YWHAE

1.72e-05732220388496
Pubmed

The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family.

YWHAB YWHAE

1.72e-05732210559254
Pubmed

cAMP-elevation mediated by β-adrenergic stimulation inhibits salt-inducible kinase (SIK) 3 activity in adipocytes.

YWHAB YWHAE

1.72e-05732222588126
Pubmed

Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets.

YWHAB YWHAE

1.72e-05732219558434
Pubmed

SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.

YWHAB YWHAE

1.72e-05732219640509
Pubmed

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

YWHAB YWHAE

1.72e-05732227030597
Pubmed

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.

YWHAB YWHAE

1.72e-05732221390248
Pubmed

A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo.

YWHAB YWHAE

1.72e-05732212383250
Pubmed

Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins.

YWHAB YWHAE

1.72e-05732236096339
Pubmed

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.

YWHAB YWHAE

1.72e-05732210869435
Pubmed

The cyclin-dependent kinase 11 interacts with 14-3-3 proteins.

YWHAB YWHAE

1.72e-05732215883043
Pubmed

Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members.

YWHAB YWHAE

1.72e-05732216868027
Pubmed

Differential Subcellular Distribution and Translocation of Seven 14-3-3 Isoforms in Response to EGF and During the Cell Cycle.

YWHAB YWHAE

1.72e-05732231906564
Pubmed

Protein binding and signaling properties of RIN1 suggest a unique effector function.

YWHAB YWHAE

2.29e-0583229144171
Pubmed

Activation of PKCβII through nuclear trafficking guided by βγ subunits of trimeric G protein and 14-3-3ε.

YWHAB YWHAE

2.29e-05832236503900
Pubmed

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.

YWHAB YWHAE

2.29e-05832216099986
Pubmed

Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest.

YWHAB YWHAE

2.29e-05832215708996
Pubmed

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.

YWHAB YWHAE

2.29e-0583229524113
Pubmed

14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.

YWHAB YWHAE

2.29e-05832223622247
Pubmed

14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules.

YWHAB YWHAE

2.29e-0583228702721
Pubmed

The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.

SSX1 SSX2

2.29e-05832212007189
Pubmed

BCR kinase phosphorylates 14-3-3 Tau on residue 233.

YWHAB YWHAE

2.29e-05832216045749
Pubmed

Regulation of the stability and activity of CDC25A and CDC25B by protein phosphatase PP2A and 14-3-3 binding.

YWHAB YWHAE

2.29e-05832230468767
Pubmed

Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation.

YWHAB YWHAE

2.29e-05832218332103
Pubmed

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding.

YWHAB YWHAE

2.29e-05832218356162
Pubmed

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.

YWHAB YWHAE

2.94e-05932218458160
Pubmed

MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage.

YWHAB YWHAE

2.94e-05932216888623
Pubmed

14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains.

YWHAB YWHAE

2.94e-05932234294877
Pubmed

Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression.

YWHAB YWHAE

2.94e-05932216581770
Pubmed

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

YWHAB YWHAE

2.94e-05932216511560
Pubmed

A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.

YWHAB YWHAE

2.94e-05932212446771
Pubmed

14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).

YWHAB YWHAE

2.94e-05932212438239
Pubmed

14-3-3ζ loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature.

YWHAB YWHAE

2.94e-05932229118970
Pubmed

Identification and characterization of the interaction between tuberin and 14-3-3zeta.

YWHAB YWHAE

2.94e-05932212176984
Pubmed

14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).

YWHAB YWHAE

2.94e-05932215057270
Pubmed

Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression.

SSX8P SSX1

2.94e-05932214611804
Pubmed

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.

YWHAB YWHAE ANXA11

3.26e-056732329357390
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

ATP6V1A ASCC3 YWHAB YWHAE RPL7 ANXA11 SPTBN2

3.32e-05102432724711643
Pubmed

Involvement of protein kinase PKN1 in G2/M delay caused by arsenite.

YWHAB YWHAE

3.67e-051032215791647
Pubmed

14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation.

YWHAB YWHAE

3.67e-051032224161943
Pubmed

Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor.

YWHAB YWHAE

3.67e-051032214505491
Pubmed

14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation.

YWHAB YWHAE

3.67e-051032225154416
InteractionSLC8A2 interactions

SLC8A3 YWHAB YWHAE

1.48e-0615313int:SLC8A2
InteractionSLC8A3 interactions

SLC8A3 YWHAB YWHAE

2.21e-0617313int:SLC8A3
InteractionMAP3K3 interactions

MAP2K4 YWHAB YWHAE CHUK

8.11e-0684314int:MAP3K3
InteractionNCAM2 interactions

MICAL3 YWHAB YWHAE

1.30e-0530313int:NCAM2
InteractionKCTD13 interactions

ATP6V1A MICAL1 MAP2K4 MICAL3 C12orf50 YWHAB YWHAE MICAL2 RPL7 SPTBN2

2.81e-0513943110int:KCTD13
InteractionFOXO3 interactions

NEB YWHAB YWHAE CHUK

3.78e-05124314int:FOXO3
InteractionDMTN interactions

UBR1 YWHAB YWHAE

4.18e-0544313int:DMTN
InteractionSASH1 interactions

YWHAB YWHAE CHUK

6.15e-0550313int:SASH1
InteractionKCNK15 interactions

YWHAB YWHAE

6.38e-058312int:KCNK15
InteractionKCNK9 interactions

YWHAB YWHAE

8.19e-059312int:KCNK9
InteractionSMN1 interactions

ATP6V1A GDF9 RPL7 SFMBT2 CHUK

8.61e-05299315int:SMN1
InteractionSH3RF3 interactions

MAP2K4 YWHAB YWHAE

8.64e-0556313int:SH3RF3
InteractionSHANK3 interactions

ATP6V1A MAP2K4 AGAP7P YWHAB YWHAE SPTBN2

9.41e-05496316int:SHANK3
InteractionOTOG interactions

YWHAB YWHAE

1.02e-0410312int:OTOG
InteractionDOCK9 interactions

NEB YWHAB YWHAE

1.12e-0461313int:DOCK9
InteractionHLA-DRB4 interactions

YWHAE ANXA11

1.50e-0412312int:HLA-DRB4
InteractionPPP1R3E interactions

YWHAB YWHAE

1.50e-0412312int:PPP1R3E
InteractionGNGT2 interactions

YWHAB KCNJ4

1.50e-0412312int:GNGT2
InteractionPDE7B interactions

YWHAB YWHAE

1.50e-0412312int:PDE7B
InteractionDLGAP1 interactions

YWHAB YWHAE KCNJ4 SPTBN2

1.60e-04180314int:DLGAP1
InteractionMAP3K10 interactions

MAP2K4 YWHAB YWHAE

1.61e-0469313int:MAP3K10
InteractionKCNK3 interactions

YWHAB YWHAE

1.77e-0413312int:KCNK3
InteractionVIM interactions

UBR1 MICAL1 ASCC3 NEB YWHAB YWHAE URGCP

1.78e-04804317int:VIM
InteractionMAP3K2 interactions

MAP2K4 YWHAB YWHAE

1.91e-0473313int:MAP3K2
InteractionMATCAP2 interactions

ATP6V1A MICAL1

2.06e-0414312int:MATCAP2
InteractionSLC8A1 interactions

YWHAB YWHAE

2.06e-0414312int:SLC8A1
InteractionNEK4 interactions

AGAP7P NEB YWHAB YWHAE RPL7 CHUK

2.25e-04582316int:NEK4
InteractionARL3 interactions

UBR1 YWHAB YWHAE

2.32e-0478313int:ARL3
InteractionLY6G5C interactions

UBR1 TEX15

2.37e-0415312int:LY6G5C
InteractionLGALS9 interactions

ATP6V1A ASCC3 YWHAB YWHAE RPL7 ANXA11

2.38e-04588316int:LGALS9
InteractionSAMSN1 interactions

YWHAB YWHAE

2.71e-0416312int:SAMSN1
InteractionTESPA1 interactions

YWHAB YWHAE

2.71e-0416312int:TESPA1
InteractionZNF395 interactions

YWHAB YWHAE

3.07e-0417312int:ZNF395
InteractionFAM53B interactions

YWHAB YWHAE

3.45e-0418312int:FAM53B
InteractionRIPK2 interactions

YWHAB YWHAE CHUK

3.77e-0492313int:RIPK2
InteractionAFAP1L1 interactions

YWHAB YWHAE

3.85e-0419312int:AFAP1L1
InteractionFAM163A interactions

YWHAB YWHAE

3.85e-0419312int:FAM163A
InteractionDLEU1 interactions

UBR1 GDF9

4.28e-0420312int:DLEU1
InteractionPARP8 interactions

YWHAB YWHAE

4.28e-0420312int:PARP8
InteractionMLXIP interactions

YWHAB YWHAE

4.28e-0420312int:MLXIP
InteractionNUDCD2 interactions

YWHAB YWHAE RPL7 SPTBN2 LRP2BP

4.36e-04424315int:NUDCD2
InteractionMICALL1 interactions

MICAL1 YWHAB YWHAE

4.41e-0497313int:MICALL1
InteractionKIF5A interactions

MICAL3 YWHAB YWHAE

4.54e-0498313int:KIF5A
InteractionMAP3K20 interactions

MAP2K4 YWHAB YWHAE

4.68e-0499313int:MAP3K20
InteractionSPATA13 interactions

YWHAB YWHAE

4.72e-0421312int:SPATA13
InteractionSTOX2 interactions

YWHAB YWHAE

4.72e-0421312int:STOX2
InteractionSPIRE2 interactions

YWHAB YWHAE

4.72e-0421312int:SPIRE2
InteractionDENND1B interactions

YWHAB YWHAE

4.72e-0421312int:DENND1B
InteractionMYO9A interactions

AK9 YWHAB YWHAE

4.96e-04101313int:MYO9A
InteractionATAT1 interactions

YWHAB YWHAE

5.19e-0422312int:ATAT1
InteractionPPP1R3D interactions

YWHAB YWHAE

5.19e-0422312int:PPP1R3D
InteractionPDE7A interactions

YWHAB YWHAE

5.19e-0422312int:PDE7A
InteractionPPP4R4 interactions

YWHAB YWHAE

5.19e-0422312int:PPP4R4
InteractionGSTA1 interactions

SSX2 YWHAE

5.19e-0422312int:GSTA1
InteractionCCSER1 interactions

YWHAB YWHAE

5.68e-0423312int:CCSER1
InteractionGLCCI1 interactions

YWHAB YWHAE

5.68e-0423312int:GLCCI1
InteractionARRB2 interactions

MAP2K4 YWHAB YWHAE RPL7 CHUK

5.94e-04454315int:ARRB2
InteractionPACS2 interactions

YWHAB YWHAE

6.19e-0424312int:PACS2
InteractionE2F8 interactions

YWHAB YWHAE

6.19e-0424312int:E2F8
InteractionCNTLN interactions

YWHAB YWHAE

6.19e-0424312int:CNTLN
InteractionBAP1 interactions

ATP6V1A MICAL3 ASCC3 TALDO1 YWHAB YWHAE RPL7 SPTBN2

6.53e-041314318int:BAP1
InteractionCDC14A interactions

ASCC3 YWHAB YWHAE

6.53e-04111313int:CDC14A
InteractionHJURP interactions

YWHAB YWHAE HMGXB4

6.53e-04111313int:HJURP
InteractionGSK3A interactions

MICAL3 ASCC3 TALDO1 YWHAB YWHAE

6.56e-04464315int:GSK3A
InteractionTMCC1 interactions

YWHAB YWHAE

6.72e-0425312int:TMCC1
InteractionLNP1 interactions

YWHAB YWHAE

6.72e-0425312int:LNP1
InteractionC6orf132 interactions

YWHAB YWHAE

6.72e-0425312int:C6orf132
InteractionMYCBP interactions

GDF9 YWHAB YWHAE

6.88e-04113313int:MYCBP
InteractionCALD1 interactions

MICAL3 YWHAE ANXA11 SPTBN2

6.95e-04265314int:CALD1
InteractionPDE3B interactions

SLC8A3 YWHAB YWHAE

7.24e-04115313int:PDE3B
InteractionPLEKHM3 interactions

YWHAB YWHAE

7.27e-0426312int:PLEKHM3
InteractionFAM83G interactions

YWHAB YWHAE

7.27e-0426312int:FAM83G
InteractionMAST4 interactions

YWHAB YWHAE

7.27e-0426312int:MAST4
InteractionPIK3R4 interactions

YWHAB YWHAE RPL7

7.80e-04118313int:PIK3R4
InteractionSPIRE1 interactions

YWHAB YWHAE

7.85e-0427312int:SPIRE1
InteractionKIF23 interactions

MICAL1 MICAL3 AK9 YWHAB YWHAE MICAL2 RPL7

8.01e-041031317int:KIF23
InteractionAAK1 interactions

YWHAB YWHAE URGCP

8.39e-04121313int:AAK1
InteractionMAP3K8 interactions

MAP2K4 CHUK

8.44e-0428312int:MAP3K8
InteractionCARMIL2 interactions

YWHAB YWHAE

8.44e-0428312int:CARMIL2
InteractionSPATA18 interactions

YWHAB YWHAE

8.44e-0428312int:SPATA18
InteractionUSP31 interactions

YWHAB YWHAE

8.44e-0428312int:USP31
InteractionWWC2 interactions

YWHAB YWHAE

8.44e-0428312int:WWC2
InteractionRGL2 interactions

YWHAB YWHAE

8.44e-0428312int:RGL2
InteractionKIAA0930 interactions

YWHAB YWHAE

8.44e-0428312int:KIAA0930
InteractionDENND2B interactions

YWHAB YWHAE

8.44e-0428312int:DENND2B
InteractionFAM13A interactions

YWHAB YWHAE

9.06e-0429312int:FAM13A
InteractionRICTOR interactions

TALDO1 YWHAB YWHAE RPL7 HMGXB4 CHUK

9.20e-04759316int:RICTOR
InteractionHLA-DRB5 interactions

YWHAE ANXA11

9.70e-0430312int:HLA-DRB5
InteractionTICRR interactions

YWHAB YWHAE

9.70e-0430312int:TICRR
InteractionMAGEC2 interactions

SSX1 SSX2

9.70e-0430312int:MAGEC2
InteractionARAP2 interactions

YWHAB YWHAE

9.70e-0430312int:ARAP2
InteractionZFP36L1 interactions

YWHAB YWHAE

9.70e-0430312int:ZFP36L1
InteractionSTAC interactions

YWHAB YWHAE

9.70e-0430312int:STAC
InteractionPABIR1 interactions

YWHAB YWHAE

1.04e-0331312int:PABIR1
InteractionMAP3K9 interactions

YWHAB YWHAE

1.04e-0331312int:MAP3K9
InteractionALS2 interactions

YWHAB YWHAE

1.04e-0331312int:ALS2
InteractionRASGRF1 interactions

YWHAB YWHAE

1.04e-0331312int:RASGRF1
InteractionCRTC1 interactions

YWHAB YWHAE

1.04e-0331312int:CRTC1
InteractionMACIR interactions

YWHAB YWHAE

1.04e-0331312int:MACIR
InteractionAKT1S1 interactions

YWHAB YWHAE

1.10e-0332312int:AKT1S1
Cytoband22q13.1

KCNJ4 HMGXB4

1.62e-038532222q13.1
CytobandXp11.23

SSX8P SSX1

2.02e-0395322Xp11.23
Cytoband6q21

MICAL1 AK9

2.06e-03963226q21
CytobandEnsembl 112 genes in cytogenetic band chrXp11

SSX8P SSX1 SSX2

2.28e-03377323chrXp11
CytobandEnsembl 112 genes in cytogenetic band chr6q21

MICAL1 AK9

3.24e-03121322chr6q21
GeneFamily14-3-3 phospho-serine/phospho-threonine binding proteins

YWHAB YWHAE

2.69e-0572121053
GeneFamilyLIM domain containing

MICAL1 MICAL3 MICAL2

4.21e-05592131218
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AGAP7P SPTBN2

2.35e-02206212682
CoexpressionMYLLYKANGAS_AMPLIFICATION_HOT_SPOT_1

SSX1 SSX2

1.89e-056302M5931
Diseasesynovial sarcoma

SSX1 SSX2

1.40e-056292C0039101
Diseasechronic widespread pain

MAP2K4 AGAP7P

2.33e-0423292EFO_0010099
DiseaseParkinson Disease

TALDO1 KCNJ4

3.17e-0385292C0030567
Diseasebrain ischemia (biomarker_via_orthology)

SLC8A3 YWHAB

4.52e-03102292DOID:2316 (biomarker_via_orthology)
Diseaseforced expiratory volume

MICAL1 MICAL3 AK9 SPTBN2

7.08e-03789294EFO_0004314

Protein segments in the cluster

PeptideGeneStartEntry
ESKVFYYKMKGDYHR

YWHAE

116

P62258
NEYFSTKYKIMRKYD

ARL14EPL

71

P0DKL9
SKVFYLKMKGDYFRY

YWHAB

116

P31946
SEYKRMYGKSLYHDI

ANXA11

471

P50995
SMHDYRYFVSKFETK

ADAM18

361

Q9Y3Q7
MSTSFDKFYKYVYSV

MAP2K4

181

P45985
KSHYKVDYSRFHKTY

KCNJ4

326

P48050
YYKDDTHYFVMTAKK

MICAL3

291

Q7RTP6
SYMVYLFDKSKTVYE

CHUK

381

O15111
EYYYKMKFFTKCVAF

LRP2BP

251

Q9P2M1
YYKDDTHYFVMTAKK

MICAL1

286

Q8TDZ2
THKKKRKHSSDDYYY

HMGXB4

71

Q9UGU5
YEKAKHYHKEYRQMY

RPL7

51

P18124
TYYSSLGDYMKYIHK

AGAP7P

291

Q5VUJ5
LHYMKKLYKTYATKE

GDF9

86

O60383
YYKDCTHYFVMTAKK

MICAL2

291

O94851
KMLTFTYKYISSFGY

AK9

1336

Q5TCS8
KYSEKISYVYMKRNY

SSX1

41

Q16384
YYYLKHQTVKMFKDR

ASCC3

1821

Q8N3C0
KEMCYKSGEYYRFHT

C12orf50

116

Q8NA57
KLLYSMKESTTKYYF

URGCP

371

Q8TCY9
TYVATYYHYFSKMKA

SPTBN2

271

O15020
KASEKIFYVYMKRKY

SSX2

41

Q16385
KYSEKISYVYMKRNY

SSX8P

41

Q7RTT4
HTKTKYTYYYGKRKK

SFMBT2

656

Q5VUG0
ESLKDFNMYFYHYSK

UBR1

826

Q8IWV7
KYMRALDEYYDKHFT

ATP6V1A

456

P38606
FRMSSHHYDYKKYGK

ZNF445

421

P59923
YNYYKKFSYKTIVMG

TALDO1

221

P37837
KYYSTKHFSSKRKYD

TEX15

1056

Q9BXT5
ADKRLLFYKYMHKKY

SLC8A3

251

P57103
LFYKYMHKKYRTDKH

SLC8A3

256

P57103
KHIKDTRYMSSYFKY

NEB

4971

P20929
TRYMSSYFKYKEAYE

NEB

4976

P20929