Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainCOS_domain

TRIM67 TRIM9

4.20e-0412482IPR017903
DomainCOS

TRIM67 TRIM9

4.20e-0412482PS51262
DomainBbox_C

TRIM67 TRIM9

6.65e-0415482IPR003649
DomainBBC

TRIM67 TRIM9

6.65e-0415482SM00502
Pubmed

A pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidance.

TRIM67 TRIM9

1.21e-05450231820781
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

ERBB4 KLHL25 KAT5 KSR2 ASB4 WNK4

1.54e-0537250622939624
Pubmed

Mammalian TRIM67 Functions in Brain Development and Behavior.

TRIM67 TRIM9

3.03e-05650229911180
Pubmed

TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis.

TRIM67 TRIM9

4.23e-05750222337885
Pubmed

Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.

KLHL25 AIMP2 TRIM9 ASB4

4.74e-0513850428786561
Pubmed

Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.

ERBB4 NBEAL2 CDC25A

9.96e-056250319367581
Pubmed

Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos.

ERBB4 CDC25A

1.10e-041150217822758
Pubmed

The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development.

KAT5 SP7

1.56e-041350237024457
Pubmed

Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.

ADAMTSL1 UNCX

2.72e-041750221897333
Pubmed

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

RIN1 ERBB4 CLNK

3.01e-049050316273093
Pubmed

Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.

KLHL25 LRRC28

3.05e-041850231541165
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ADAMTSL1 NBEAL2 PHLPP1

4.73e-041055039628581
Pubmed

Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding.

MEMO1 BPHL MYO1C NDUFV1 ARHGEF10L

5.35e-0446450532457219
Pubmed

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.

CTTNBP2 TRIM9 CDC25A

8.41e-0412850325332235
Pubmed

Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.

ZNF536 ERBB4

9.17e-043150227798109
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TRIM9 NBEAL2 DHX34 CEMIP2 ARHGEF10L

9.63e-0452950514621295
Pubmed

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.

ZNF536 ERBB4

1.04e-033350224159190
Pubmed

Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.

ERBB4 UNCX

1.10e-033450212086465
Pubmed

DNA Damage Regulates Translation through β-TRCP Targeting of CReP.

TRIM9 CDC25A

1.17e-033550226091241
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

CTTNBP2 MYO1C INTS4 CDC25A DOP1B

1.37e-0357350528330616
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ZNF536 KAT5 A2ML1 NFXL1 CDC25A NDUFV1

1.39e-0385750625609649
ToppCellPosterior_cortex-Neuronal-Inhibitory|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ZNF536 ERBB4 TRIM67 CLNK ALOX15B

1.23e-061675059a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Tmem182|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 ADAMTSL1 ZNF683 CLNK

1.15e-05124504690595d710b57b7cff8029a3bb06a8dd7e3c03c1
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Krt73|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZNF536 ERBB4 ADAMTSL1 SP7

1.42e-051315049ca209a8652aae603c4a867ea06b06ac51e7d189
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ERBB4 TRIM67 CLNK ALOX15B

1.80e-05139504408bc31aa5e1c2b379f79198fe8b5411f8d7bd08
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ERBB4 TRIM67 CLNK ALOX15B

2.07e-0514450404f9054895be2275eecda687a6eeb02fa5ec69b9
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ZNF536 ERBB4 TRIM67 CLNK

2.76e-05155504105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ZNF536 ERBB4 TRIM67 CLNK

3.05e-051595047f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAB21L4 NBEAL2 PHLPP1 ARHGEF10L

3.44e-05164504d6f71d804bb65301c02ea4e6673e20688b5fcd5b
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 ERBB4 WDR97 TRIM9

3.78e-05168504948d9e9972bd2a4b503d55fa69b70dd568a35a67
ToppCellFrontal_cortex-Neuronal-Inhibitory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ZNF536 ERBB4 TRIM67 ALOX15B

3.87e-0516950478eb70dd916724e476eabccf18fb7fcec4210308
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CTTNBP2 UNCX CCNP ARHGEF10L

3.96e-051705045d5f208682be21ed58320f5fc083a7898f8712da
ToppCell5'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KSR2 CATSPERG WNK4 DOP1B

4.05e-0517150448125d825ca2d7ef34564250f5b47d2a579e03c9
ToppCellCOVID-19-kidney-CD-IC-A|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERBB4 ADAMTSL1 CTTNBP2 CLNK

4.53e-0517650445028197364c64e93e3ffe86aff773d47a477d49
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Interneuron|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ZNF536 ERBB4 CEMIP2

4.89e-0563503c10d344bf32a091deb79e1f128f7dd5e9f4abaa3
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ZNF683 CLNK CEMIP2 ARHGEF10L

4.94e-05180504f24d4cbba4cb50fce3b3d9c4629aa856d9b05358
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CTTNBP2 UNCX CCNP ARHGEF10L

5.16e-05182504eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 NBEAL2 KSR2 DOP1B

6.61e-0519450446070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 NBEAL2 KSR2 DOP1B

6.61e-05194504abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 ERBB4 TRIM9 CEMIP2

7.15e-05198504c506334d81af672ef9ddc8c4fd2a790bdb58e63e
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 ERBB4 TRIM9 CEMIP2

7.29e-05199504ce699726ac4825c65bf934cb9a76202ad7340596
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 ERBB4 TRIM9 CEMIP2

7.29e-051995048d13a9ea87f685b5a34b84c4571db6be753cf2d9
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 ERBB4 TRIM9 CEMIP2

7.29e-05199504f1d5808ccb1d5d4e2d34f864e705e2484000e88f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Interneuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

ZNF536 ERBB4 CEMIP2

9.26e-05785038ad496ccbffb62a50f195c3789a95d8c80e2272d
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf|Thalamus / BrainAtlas - Mouse McCarroll V32

MAB21L4 DCST1 SP7

9.26e-05785035b45aacaff2a2b98c4ef8e7ac51ad482a69a1d8b
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)|Thalamus / BrainAtlas - Mouse McCarroll V32

MAB21L4 DCST1 SP7

9.26e-0578503afed2f358c8a33889931bc5ad8cb24f92323e6f8
DiseaseOpitz GBBB syndrome (implicated_via_orthology)

TRIM67 TRIM9

4.04e-056492DOID:0080697 (implicated_via_orthology)
Diseaseunipolar depression, depressive symptom measurement

CTTNBP2 KSR2

8.56e-0426492EFO_0003761, EFO_0007006
Diseasecorpus callosum anterior volume measurement

ADAMTSL1 CTTNBP2

1.92e-0339492EFO_0010295
Diseasedentate gyrus volume measurement

TMEM219 ALOX15B

1.92e-0339492EFO_0010083
Diseasecognitive inhibition measurement

UNCX A2ML1

3.15e-0350492EFO_0007969
Diseaseidiopathic osteonecrosis of the femoral head

CTTNBP2 CLNK

3.40e-0352492EFO_1001930
Diseasemonoclonal gammopathy

ERBB4 KSR2

3.53e-0353492EFO_0000203
Diseaseheart failure

ADAMTSL1 MYO1C ACTN2

3.61e-03185493EFO_0003144
Diseaseleft ventricular diastolic function measurement

MYO1C SP7

3.66e-0354492EFO_0008204
Diseaseidiopathic pulmonary fibrosis

KLHL25 TMEM42

4.07e-0357492EFO_0000768
Diseaseirritable bowel syndrome symptom measurement

TRIM67 DOP1B

4.21e-0358492EFO_0021536

Protein segments in the cluster

PeptideGeneStartEntry
TFLLHIHGLPLSPKR

CATSPERG

1051

Q6ZRH7
DHPHLVRLLGVCLSP

ERBB4

776

Q15303
PVLCLRHSPFHLLAG

ARHGEF10L

926

Q9HCE6
KDGLGLCALIHRHRP

ACTN2

181

P35609
LHNRCHRAIPLLSLP

ASB4

396

Q9Y574
LKKRHLHCISFLVPP

A2ML1

71

A8K2U0
FRLHHPGPLLCLGLL

CCNP

201

Q9H8S5
CLKFLGSRHPTLVLP

INTS4

506

Q96HW7
CLATRKLPHFLHPQR

MAB21L4

331

Q08AI8
SKSRPLGCLHPCILR

NFXL1

706

Q6ZNB6
RLAQCLHPALPSGVH

DOP1B

66

Q9Y3R5
KEAPPCHLLIIHRGD

KSR2

451

Q6VAB6
LQRHLTKCDLRHPPG

KAT5

276

Q92993
LSVLLHCEAIGHPRP

ADAMTSL1

1196

Q8N6G6
LIPLGLLCALLPQHH

EDEM2

6

Q9BV94
PCARPRKAGHTLLIL

KLHL25

286

Q9H0H3
LLNKAVLHGCPLPRA

CTTNBP2

1406

Q8WZ74
KAPRHPLADILHRGC

DCST1

621

Q5T197
SHLLVPLGLAKPAHL

CEMIP2

1301

Q9UHN6
LLGALLKCIHPSPGR

FAM187B

346

Q17R55
FKHLPDGNICRHLLP

BPHL

216

Q86WA6
LPRALSLSCPVPHLH

C5orf34

296

Q96MH7
HCGLHAPLTPLERIA

DHX34

1071

Q14147
HSLPQKLLGCSPALK

CDC25A

106

P30304
ILGPSHHVPLSRCAL

MEMO1

76

Q9Y316
LGPMVLSKHPHLCLV

ABCB8

96

Q9NUT2
LATLRQLPHCHPLFK

ALOX15B

386

O15296
HPALRLQGALHPARC

RASL10A

186

Q92737
LHCSVLKPLRPILAA

RIN1

436

Q13671
PRSLLELLHCPLGHC

LRRC28

301

Q86X40
LRHDPHKLLEGCLVG

NDUFV1

131

P49821
DGHLVKTAPLRCPSL

NBEAL2

701

Q6ZNJ1
PPLSLLVLHRLLCEH

AIMP2

131

Q13155
KQCHLTQPLPLTRHL

CLNK

411

Q7Z7G1
LKCHPSRGPFAKHRL

TRIM67

236

Q6ZTA4
HSLALLGVPHCRKPL

TMEM256

51

Q8N2U0
LCTAPIPRKHLHRLV

SLC5A2

546

P31639
AGLRKKPIHSCHIPG

SP7

286

Q8TDD2
PVHCRPELKKLLHGL

WDR97

1301

A6NE52
HFGISLPLKICLHLG

nan

11

Q86TA4
RCHPPRGPLAKHRLV

TRIM9

196

Q9C026
HSLLGCLNLVPPLKS

ZNF536

486

O15090
HHPPLVCATLILLLL

TMEM219

16

Q86XT9
DKCVPLLTGHPHLKI

PHLPP1

1026

O60346
ILCGLTLIHRKLPPT

TMEM42

136

Q69YG0
LHSRVPPILHRDLKC

WNK4

291

Q96J92
LKLHHRLHAPQPCGL

ZNF683

441

Q8IZ20
PCAPRTLIGKGHFLL

UNCX

366

A6NJT0
HGSQPPRRCLALLHL

XKR8

76

Q9H6D3
LKPHRALHTLGLAKC

NLRP13

976

Q86W25
VVHPHRPCKLALGSD

MYO1C

16

O00159