Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ATP8B3 ABCB1 CLPTM1L ANO3	3.28e-04	51	129	4	GO:0140303
GeneOntologyMolecularFunction	NAADP-sensitive calcium-release channel activity	MCOLN3 MCOLN2	4.09e-04	5	129	2	GO:0072345
GeneOntologyMolecularFunction	beta-galactosidase activity	GLB1L3 GLB1L2	4.09e-04	5	129	2	GO:0004565
GeneOntologyMolecularFunction	semaphorin receptor binding	SEMA6B SEMA4C SEMA6A	4.24e-04	23	129	3	GO:0030215
GeneOntologyMolecularFunction	phosphatidylinositol-5-phosphate binding	PLCZ1 TOM1 WASHC2A	4.24e-04	23	129	3	GO:0010314
GeneOntologyBiologicalProcess	phospholipid translocation	ATP8B3 ABCB1 CLPTM1L PRKCD ANO3	2.22e-05	55	127	5	GO:0045332
GeneOntologyBiologicalProcess	lipid translocation	ATP8B3 ABCB1 CLPTM1L PRKCD ANO3	3.41e-05	60	127	5	GO:0034204
GeneOntologyBiologicalProcess	regulation of membrane lipid distribution	ATP8B3 ABCB1 CLPTM1L PRKCD ANO3	5.02e-05	65	127	5	GO:0097035
Domain	FOXO_KIX-bd	FOXO1 FOXO3	4.44e-05	2	125	2	IPR032068
Domain	DNA_mismatch_repair_MutS	MSH2 MSH5	4.44e-05	2	125	2	IPR011184
Domain	FOXO_KIX_bdg	FOXO1 FOXO3	4.44e-05	2	125	2	PF16675
Domain	PKD_channel	PKD1 MCOLN3 MCOLN2	4.64e-05	11	125	3	PF08016
Domain	PKD1_2_channel	PKD1 MCOLN3 MCOLN2	4.64e-05	11	125	3	IPR013122
Domain	FOXO-TAD	FOXO1 FOXO3	1.33e-04	3	125	2	IPR032067
Domain	FOXO-TAD	FOXO1 FOXO3	1.33e-04	3	125	2	PF16676
Domain	TF_fork_head_CS_2	FOXO1 FOXO3 FOXD1 FOXE3	2.51e-04	46	125	4	IPR030456
Domain	Glyco_hydro_35	GLB1L3 GLB1L2	2.64e-04	4	125	2	PF01301
Domain	GLYCOSYL_HYDROL_F35	GLB1L3 GLB1L2	2.64e-04	4	125	2	PS01182
Domain	Gly_Hdrlase_35_cat	GLB1L3 GLB1L2	2.64e-04	4	125	2	IPR031330
Domain	Glycoside_Hdrlase_35	GLB1L3 GLB1L2	2.64e-04	4	125	2	IPR001944
Domain	B-gal_1-like	GLB1L3 GLB1L2	2.64e-04	4	125	2	IPR026283
Domain	TF_fork_head_CS_1	FOXO1 FOXO3 FOXD1 FOXE3	2.73e-04	47	125	4	IPR018122
Domain	Semaphorin	SEMA6B SEMA4C SEMA6A	3.07e-04	20	125	3	IPR027231
Domain	FH	FOXO1 FOXO3 FOXD1 FOXE3	3.21e-04	49	125	4	SM00339
Domain	FORK_HEAD_1	FOXO1 FOXO3 FOXD1 FOXE3	3.21e-04	49	125	4	PS00657
Domain	FORK_HEAD_2	FOXO1 FOXO3 FOXD1 FOXE3	3.21e-04	49	125	4	PS00658
Domain	Fork_head_dom	FOXO1 FOXO3 FOXD1 FOXE3	3.21e-04	49	125	4	IPR001766
Domain	FORK_HEAD_3	FOXO1 FOXO3 FOXD1 FOXE3	3.21e-04	49	125	4	PS50039
Domain	Forkhead	FOXO1 FOXO3 FOXD1 FOXE3	3.21e-04	49	125	4	PF00250
Domain	MUTSd	MSH2 MSH5	4.39e-04	5	125	2	SM00533
Domain	MUTSac	MSH2 MSH5	4.39e-04	5	125	2	SM00534
Domain	MutS_V	MSH2 MSH5	4.39e-04	5	125	2	PF00488
Domain	DNA_mismatch_repair_MutS_clamp	MSH2 MSH5	4.39e-04	5	125	2	IPR007861
Domain	DNA_MISMATCH_REPAIR_2	MSH2 MSH5	4.39e-04	5	125	2	PS00486
Domain	MutS_IV	MSH2 MSH5	4.39e-04	5	125	2	PF05190
Domain	MutS_III	MSH2 MSH5	4.39e-04	5	125	2	PF05192
Domain	DNA_mismatch_repair_MutS_C	MSH2 MSH5	4.39e-04	5	125	2	IPR000432
Domain	DUF4704	NBEAL1 WDFY3	4.39e-04	5	125	2	IPR031570
Domain	DNA_mismatch_repair_MutS_core	MSH2 MSH5	4.39e-04	5	125	2	IPR007696
Domain	FATC	SMG1 PRKDC	4.39e-04	5	125	2	PF02260
Domain	DUF4704	NBEAL1 WDFY3	4.39e-04	5	125	2	PF15787
Domain	ARM-type_fold	SMG1 NBEAL1 UBR4 ELMO2 ARMC5 TTC12 PRKDC WDFY3 EIF4G3	4.65e-04	339	125	9	IPR016024
Domain	PH_BEACH	NBEAL1 WDFY3	6.55e-04	6	125	2	PF14844
Domain	FAT	SMG1 PRKDC	6.55e-04	6	125	2	PS51189
Domain	FATC	SMG1 PRKDC	6.55e-04	6	125	2	PS51190
Domain	FATC_dom	SMG1 PRKDC	6.55e-04	6	125	2	IPR003152
Domain	PIK_FAT	SMG1 PRKDC	6.55e-04	6	125	2	IPR014009
Domain	FATC	SMG1 PRKDC	6.55e-04	6	125	2	SM01343
Domain	ZnF_UBR1	UBR4 UBR5	9.13e-04	7	125	2	SM00396
Domain	ZF_UBR	UBR4 UBR5	9.13e-04	7	125	2	PS51157
Domain	zf-UBR	UBR4 UBR5	9.13e-04	7	125	2	PF02207
Domain	Znf_UBR	UBR4 UBR5	9.13e-04	7	125	2	IPR003126
Domain	Semap_dom	SEMA6B SEMA4C SEMA6A	1.15e-03	31	125	3	IPR001627
Domain	SEMA	SEMA6B SEMA4C SEMA6A	1.15e-03	31	125	3	PS51004
Domain	Sema	SEMA6B SEMA4C SEMA6A	1.15e-03	31	125	3	SM00630
Domain	Sema	SEMA6B SEMA4C SEMA6A	1.15e-03	31	125	3	PF01403
Domain	DHC_N1	DNAH10 DYNC1H1	1.21e-03	8	125	2	PF08385
Domain	PH-BEACH_dom	NBEAL1 WDFY3	1.21e-03	8	125	2	IPR023362
Domain	-	NBEAL1 WDFY3	1.21e-03	8	125	2	2.30.29.40
Domain	PH_BEACH	NBEAL1 WDFY3	1.21e-03	8	125	2	PS51783
Domain	Dynein_heavy_dom-1	DNAH10 DYNC1H1	1.21e-03	8	125	2	IPR013594
Domain	Plexin_repeat	SEMA6B SEMA4C SEMA6A	1.26e-03	32	125	3	IPR002165
Domain	PSI	SEMA6B SEMA4C SEMA6A	1.26e-03	32	125	3	PF01437
Domain	BEACH	NBEAL1 WDFY3	1.55e-03	9	125	2	PS50197
Domain	Beach	NBEAL1 WDFY3	1.55e-03	9	125	2	PF02138
Domain	-	NBEAL1 WDFY3	1.55e-03	9	125	2	1.10.1540.10
Domain	Beach	NBEAL1 WDFY3	1.55e-03	9	125	2	SM01026
Domain	BEACH_dom	NBEAL1 WDFY3	1.55e-03	9	125	2	IPR000409
Domain	PSI	SEMA6B SEMA4C SEMA6A	3.17e-03	44	125	3	IPR016201
Domain	PSI	SEMA6B SEMA4C SEMA6A	3.60e-03	46	125	3	SM00423
Domain	-	CLGN NBEAL1 CELSR3 WDFY3	3.81e-03	95	125	4	2.60.120.200
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DYNC1H1	3.84e-03	14	125	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DYNC1H1	3.84e-03	14	125	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DYNC1H1	3.84e-03	14	125	2	IPR013602
Domain	DHC_N2	DNAH10 DYNC1H1	3.84e-03	14	125	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH10 DYNC1H1	3.84e-03	14	125	2	IPR011704
Domain	MT	DNAH10 DYNC1H1	3.84e-03	14	125	2	PF12777
Domain	AAA_8	DNAH10 DYNC1H1	3.84e-03	14	125	2	PF12780
Domain	AAA_5	DNAH10 DYNC1H1	3.84e-03	14	125	2	PF07728
Domain	DHC_fam	DNAH10 DYNC1H1	4.41e-03	15	125	2	IPR026983
Domain	Dynein_heavy	DNAH10 DYNC1H1	4.41e-03	15	125	2	PF03028
Domain	PI3/4_kinase_CS	SMG1 PRKDC	4.41e-03	15	125	2	IPR018936
Domain	Dynein_heavy_dom	DNAH10 DYNC1H1	4.41e-03	15	125	2	IPR004273
Domain	-	SMG1 PRKDC	5.01e-03	16	125	2	1.10.1070.11
Domain	PI3Kc	SMG1 PRKDC	5.01e-03	16	125	2	SM00146
Domain	TF_T-box	EOMES MGA	5.66e-03	17	125	2	IPR001699
Domain	TBOX	EOMES MGA	5.66e-03	17	125	2	SM00425
Domain	TF_T-box_CS	EOMES MGA	5.66e-03	17	125	2	IPR018186
Domain	-	EOMES MGA	5.66e-03	17	125	2	2.60.40.820
Domain	TBOX_3	EOMES MGA	5.66e-03	17	125	2	PS50252
Domain	T-box	EOMES MGA	5.66e-03	17	125	2	PF00907
Domain	TBOX_1	EOMES MGA	5.66e-03	17	125	2	PS01283
Domain	TBOX_2	EOMES MGA	5.66e-03	17	125	2	PS01264
Domain	LRR_6	NLRP12 NRROS CIITA	5.96e-03	55	125	3	PF13516
Domain	VWA	VWF COL6A6 ITGAX	6.27e-03	56	125	3	PF00092
Domain	PI3_PI4_kinase	SMG1 PRKDC	6.34e-03	18	125	2	PF00454
Domain	PI3_4_KINASE_1	SMG1 PRKDC	6.34e-03	18	125	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 PRKDC	6.34e-03	18	125	2	PS00916
Domain	Terpenoid_cyclase/PrenylTrfase	PGGT1B ELMO2	6.34e-03	18	125	2	IPR008930
Domain	PI3/4_kinase_cat_dom	SMG1 PRKDC	6.34e-03	18	125	2	IPR000403
Domain	PI3_4_KINASE_3	SMG1 PRKDC	6.34e-03	18	125	2	PS50290
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	HAUS6 HYOU1 UBR4 MSH2 OCRL SLC25A3 OXCT1 UBR5 BSG UCHL5 MCAT PRKDC DYNC1H1	1.06e-07	534	129	13	35032548
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SF3B4 VWF UBR4 PEG3 HECTD4 APBB1 ZNF224 ADAMTS8 UBASH3A SERPINE2 COMMD1 CELSR3 SLF2 NMT2 PKD1 PRKDC WDFY3 EIF4G3 DYNC1H1	2.91e-07	1285	129	19	35914814
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SMG1 CLGN HYOU1 MARK3 NPEPPS UBR4 TOM1 SMPD4 MSH2 NPM3 SLC25A3 LIG3 CLPTM1L OXCT1 COMMD1 UBR5 BSG PURB PRKDC DYNC1H1	3.68e-07	1440	129	20	30833792
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYH6 LPCAT1 HYOU1 NPEPPS UBR4 TRIM29 SLC25A3 UBR5 BSG PURB HPX PRKDC DYNC1H1	9.29e-07	647	129	13	26618866
Pubmed	mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.	FOXO1 FOXO3 TRIM63	9.89e-07	6	129	3	24570486
Pubmed	Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.	FOXO1 FOXO3 WDFY3	2.75e-06	8	129	3	23640897
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	VWF MTSS1 MSH2 ADAMTS13 ADAMTS8 PURB PKD1	3.71e-06	171	129	7	20201926
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	CDK20 FOXO1 FOXO3 UBR4 SMPD4 TRIM29 LIG3 PHKG2 BBX ZFHX4 UBR5 MGA DYNC1H1 FOXD1	3.90e-06	857	129	14	25609649
Pubmed	Noggin is required for correct guidance of dorsal root ganglion axons.	EPHB3 SEMA6B SEMA4C SEMA6A	3.99e-06	29	129	4	12435358
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	SLC25A5 SLC25A3 UBR5 PRKDC	4.59e-06	30	129	4	32867711
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	SF3B4 BBS2 SMPD4 TRIM29 TIAM2 CASP12 LIG3 UBR5 BSG UCHL5 MGA GOLGA2 DYNC1H1	4.95e-06	754	129	13	35906200
Pubmed	Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.	PHKG2 PRKCD PRKDC	5.87e-06	10	129	3	25495526
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	LPCAT1 CLGN UBR4 SMPD4 SYS1 CLPTM1L UBR5 ELMO2 FAM3C PRKDC MGA GOLGA2	6.55e-06	657	129	12	36180527
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	SLC25A5 SPTA1 UBR4 UBASH3A PRKCD PRKDC VASP DYNC1H1	7.23e-06	266	129	8	19380743
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	LPCAT1 CLGN HYOU1 UBR4 TOM1 MSH2 OCRL SEMA4C UBR5 BSG UCHL5 PRKDC EIF4G3 DYNC1H1	1.13e-05	942	129	14	31073040
Pubmed	GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.	FOXO1 FOXO3	1.37e-05	2	129	2	24895270
Pubmed	Plasma ADAMTS13 activity and von Willebrand factor antigen and activity in patients with subarachnoid haemorrhage.	VWF ADAMTS13	1.37e-05	2	129	2	28102428
Pubmed	FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway.	FOXO1 FOXO3	1.37e-05	2	129	2	24448243
Pubmed	The association between the L1565 variant of von Willebrand factor and susceptibility to proteolysis by ADAMTS13.	VWF ADAMTS13	1.37e-05	2	129	2	17296575
Pubmed	Interrelationship between ADAMTS13 activity, von Willebrand factor, and complement activation in remission from immune-mediated trhrombotic thrombocytopenic purpura.	VWF ADAMTS13	1.37e-05	2	129	2	32065383
Pubmed	Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring.	FOXO1 FOXO3	1.37e-05	2	129	2	25010393
Pubmed	ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.	VWF ADAMTS13	1.37e-05	2	129	2	22983446
Pubmed	N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity.	VWF ADAMTS13	1.37e-05	2	129	2	18981290
Pubmed	The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor.	VWF ADAMTS13	1.37e-05	2	129	2	15975930
Pubmed	Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis.	FOXO1 FOXO3	1.37e-05	2	129	2	24269635
Pubmed	A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13.	VWF ADAMTS13	1.37e-05	2	129	2	21779388
Pubmed	Platelet-free shear flow assay facilitates analysis of shear-dependent functions of VWF and ADAMTS13.	VWF ADAMTS13	1.37e-05	2	129	2	25201004
Pubmed	Interactions of von Willebrand factor and ADAMTS13 in von Willebrand disease and thrombotic thrombocytopenic purpura.	VWF ADAMTS13	1.37e-05	2	129	2	25010251
Pubmed	Von Willebrand factor and ADAMTS13: a candidate couple for preeclampsia pathophysiology.	VWF ADAMTS13	1.37e-05	2	129	2	21512165
Pubmed	Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus.	VWF ADAMTS13	1.37e-05	2	129	2	26168189
Pubmed	Multi-step binding of ADAMTS-13 to von Willebrand factor.	VWF ADAMTS13	1.37e-05	2	129	2	19765212
Pubmed	Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling.	FOXO1 FOXO3	1.37e-05	2	129	2	16952979
Pubmed	Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization.	FOXO1 FOXO3	1.37e-05	2	129	2	16709600
Pubmed	FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients.	VWF ADAMTS13	1.37e-05	2	129	2	24740645
Pubmed	MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo.	CIITA PRKDC	1.37e-05	2	129	2	16081800
Pubmed	Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation.	VWF ADAMTS13	1.37e-05	2	129	2	27444201
Pubmed	Forkhead box O3 promotes colon cancer proliferation and drug resistance by activating MDR1 expression.	FOXO3 ABCB1	1.37e-05	2	129	2	30623608
Pubmed	Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis.	VWF ADAMTS13	1.37e-05	2	129	2	24106205
Pubmed	Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure.	VWF ADAMTS13	1.37e-05	2	129	2	19190805
Pubmed	Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia.	VWF ADAMTS13	1.37e-05	2	129	2	19190814
Pubmed	ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men.	VWF ADAMTS13	1.37e-05	2	129	2	17053057
Pubmed	Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients.	VWF ADAMTS13	1.37e-05	2	129	2	33606732
Pubmed	Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.	VWF ADAMTS13	1.37e-05	2	129	2	20200350
Pubmed	Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13.	VWF ADAMTS13	1.37e-05	2	129	2	19812385
Pubmed	Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage.	VWF ADAMTS13	1.37e-05	2	129	2	29729651
Pubmed	Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.	VWF ADAMTS13	1.37e-05	2	129	2	16141351
Pubmed	Foxo in T Cells Regulates Thermogenic Program through Ccr4/Ccl22 Axis.	FOXO1 FOXO3	1.37e-05	2	129	2	31756626
Pubmed	Domain-specific mechanical modulation of VWF-ADAMTS13 interaction.	VWF ADAMTS13	1.37e-05	2	129	2	31067148
Pubmed	Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).	VWF ADAMTS13	1.37e-05	2	129	2	21705658
Pubmed	Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13.	VWF ADAMTS13	1.37e-05	2	129	2	33343584
Pubmed	Zinc and calcium ions cooperatively modulate ADAMTS13 activity.	VWF ADAMTS13	1.37e-05	2	129	2	16286459
Pubmed	von Willebrand factor self-association is regulated by the shear-dependent unfolding of the A2 domain.	VWF ADAMTS13	1.37e-05	2	129	2	30936056
Pubmed	von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans.	VWF ADAMTS13	1.37e-05	2	129	2	25977583
Pubmed	Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.	VWF ADAMTS13	1.37e-05	2	129	2	16322474
Pubmed	An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF.	VWF ADAMTS13	1.37e-05	2	129	2	20032502
Pubmed	Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors.	FOXO1 FOXO3	1.37e-05	2	129	2	15069012
Pubmed	Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling.	FOXO1 FOXO3	1.37e-05	2	129	2	27936162
Pubmed	Role of PKCdelta in IFN-gamma-inducible CIITA gene expression.	CIITA PRKCD	1.37e-05	2	129	2	17346795
Pubmed	Lower FOXO3 mRNA expression in granulosa cells is involved in unexplained infertility.	FOXO1 FOXO3	1.37e-05	2	129	2	28621049
Pubmed	Development of a Hyperactive Primary Hemostatic System During Off-Pump Lung Transplantation Resulting From an Unbalance Between von Willebrand Factor and Its Cleaving Protease ADAMTS13.	VWF ADAMTS13	1.37e-05	2	129	2	25846964
Pubmed	Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules.	MCOLN3 MCOLN2	1.37e-05	2	129	2	22753890
Pubmed	The Role of von Willebrand Factor, ADAMTS13, and Cerebral Artery Thrombus Composition in Patient Outcome Following Mechanical Thrombectomy for Acute Ischemic Stroke.	VWF ADAMTS13	1.37e-05	2	129	2	29887594
Pubmed	Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13.	VWF ADAMTS13	1.37e-05	2	129	2	19897584
Pubmed	Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration.	FOXO1 FOXO3	1.37e-05	2	129	2	28430387
Pubmed	Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism.	VWF ADAMTS13	1.37e-05	2	129	2	36736832
Pubmed	Foxd1 is a mediator and indicator of the cell reprogramming process.	FOXO1 FOXD1	1.37e-05	2	129	2	24496101
Pubmed	Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity.	VWF ADAMTS13	1.37e-05	2	129	2	32441353
Pubmed	The p.R1819_C1948delinsS mutation makes von Willebrand factor ADAMTS13-resistant and reduces its collagen-binding capacity.	VWF ADAMTS13	1.37e-05	2	129	2	25904363
Pubmed	ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.	VWF ADAMTS13	1.37e-05	2	129	2	12775718
Pubmed	Altered von Willebrand Factor and ADAMTS13 Levels in Children With Cirrhosis and Extrahepatic Portal Hypertension.	VWF ADAMTS13	1.37e-05	2	129	2	33369998
Pubmed	Decreased von Willebrand factor ristocetin cofactor activity and increased ADAMTS13 antigen increase postoperative drainage after coronary artery bypass grafting.	VWF ADAMTS13	1.37e-05	2	129	2	24351199
Pubmed	Disulfide bond reduction of von Willebrand factor by ADAMTS-13.	VWF ADAMTS13	1.37e-05	2	129	2	20946172
Pubmed	Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?	VWF ADAMTS13	1.37e-05	2	129	2	16203734
Pubmed	ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery.	VWF ADAMTS13	1.37e-05	2	129	2	28428179
Pubmed	Identification of ADAMTS13 peptide sequences binding to von Willebrand factor.	VWF ADAMTS13	1.37e-05	2	129	2	19944670
Pubmed	ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals.	VWF ADAMTS13	1.37e-05	2	129	2	18983500
Pubmed	Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease.	VWF ADAMTS13	1.37e-05	2	129	2	25782102
Pubmed	[Analysis of FOXO1A and FOXO3A Gene Allele Association with Human Longevity].	FOXO1 FOXO3	1.37e-05	2	129	2	27529982
Pubmed	Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men.	VWF ADAMTS13	1.37e-05	2	129	2	30745808
Pubmed	Activity of Von Willebrand factor and levels of VWF-cleaving protease (ADAMTS13) in preterm and full term neonates.	VWF ADAMTS13	1.37e-05	2	129	2	28087247
Pubmed	ADAMTS-13-VWF axis in sickle cell disease patients.	VWF ADAMTS13	1.37e-05	2	129	2	33404693
Pubmed	Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells.	FOXO1 FOXO3	1.37e-05	2	129	2	25952685
Pubmed	The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis.	FOXO1 FOXO3	1.37e-05	2	129	2	32332845
Pubmed	Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene.	MSH2 MSH5	1.37e-05	2	129	2	9740671
Pubmed	A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.	VWF ADAMTS13	1.37e-05	2	129	2	19587373
Pubmed	Molecular mapping of the chloride-binding site in von Willebrand factor (VWF): energetics and conformational effects on the VWF/ADAMTS-13 interaction.	VWF ADAMTS13	1.37e-05	2	129	2	16899464
Pubmed	Blood group antigen A on von Willebrand factor is more protective against ADAMTS13 cleavage than antigens B and H.	VWF ADAMTS13	1.37e-05	2	129	2	30929293
Pubmed	Assessment of the Diagnostic Value of Plasma Levels, Activities, and Their Ratios of von Willebrand Factor and ADAMTS13 in Patients with Cerebral Infarction.	VWF ADAMTS13	1.37e-05	2	129	2	25916953
Pubmed	von Willebrand factor and its cleaving protease ADAMTS13 balance in coronary artery vessels: Lessons learned from thrombotic thrombocytopenic purpura. A narrative review.	VWF ADAMTS13	1.37e-05	2	129	2	28521259
Pubmed	Binding of ADAMTS13 to von Willebrand factor.	VWF ADAMTS13	1.37e-05	2	129	2	15824096
Pubmed	Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis.	VWF ADAMTS13	1.37e-05	2	129	2	15886321
Pubmed	Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions.	VWF ADAMTS13	1.37e-05	2	129	2	16102037
Pubmed	Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.	VWF ADAMTS13	1.37e-05	2	129	2	24713928
Pubmed	The expression of ADAMTS13 in human microvascular endothelial cells.	VWF ADAMTS13	1.37e-05	2	129	2	26366828
Pubmed	Relationship between ADAMTS13 activity, von Willebrand factor antigen levels and platelet function in the early and late phases after TIA or ischaemic stroke.	VWF ADAMTS13	1.37e-05	2	129	2	25498844
Pubmed	Plasma ADAMTS13, von Willebrand Factor (VWF), and VWF Propeptide Profiles in Patients With Connective Tissue Diseases and Antiphospholipid Syndrome.	VWF ADAMTS13	1.37e-05	2	129	2	26759371
Pubmed	Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth.	FOXO1 FOXO3	1.37e-05	2	129	2	30511639
Pubmed	VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13.	VWF ADAMTS13	1.37e-05	2	129	2	14512308
Pubmed	Physical stress as a model to study variations in ADAMTS-13 activity, von Willebrand factor level and platelet activation.	VWF ADAMTS13	1.37e-05	2	129	2	16634765
Pubmed	C2362F mutation gives rise to an ADAMTS13-resistant von Willebrand factor.	VWF ADAMTS13	1.37e-05	2	129	2	23446343
Interaction	FURIN interactions	VWF HYOU1 SLC25A5 UBR4 SMPD4 SLC25A3 LIG3 SERPINE2 SERPINB8 BSG PRKDC WDFY3 GOLGA2	8.31e-09	255	127	13	int:FURIN
Cytoband	11q25	GLB1L3 ADAMTS8 GLB1L2	5.37e-05	26	129	3	11q25
GeneFamily	Forkhead boxes	FOXO1 FOXO3 FOXD1 FOXE3	5.35e-05	43	87	4	508
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA6B SEMA4C SEMA6A	1.16e-04	20	87	3	736
GeneFamily	MutS homologs\|PWWP domain containing	MSH2 MSH5	2.27e-04	5	87	2	1026
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR4 UBR5	4.73e-04	7	87	2	785
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 WDFY3	8.06e-04	9	87	2	1230
GeneFamily	T-boxes	EOMES MGA	3.33e-03	18	87	2	766
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS13 ADAMTS8	3.71e-03	19	87	2	50
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	VWF COL6A6 GLB1L3 HPX MCOLN2	4.61e-06	84	129	5	39196f7af1a3199ca611acbe7b2e7a76d79c8fdd
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)\|Thalamus / BrainAtlas - Mouse McCarroll V32	VWF COL6A6 GLB1L3 HPX MCOLN2	4.61e-06	84	129	5	79cdb04e91aa119a128f0fef7a09b59a0edf00a0
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	VWF COL6A6 GLB1L3 HPX MCOLN2	4.61e-06	84	129	5	66fc8327fc9c0f9a135e874ad2056ca414cd5148
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SF3B4 SPSB1 EML5 ELF4 MCAT MAPK7	6.79e-06	158	129	6	91d8c93af328c3bbebe1d8f019b94849ebc548c0
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 VWF SERPINB8 MCTP1 BSG FAM3C	9.01e-06	166	129	6	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 VWF SERPINB8 MCTP1 BSG FAM3C	9.01e-06	166	129	6	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell	facs-GAT-Fat-18m-Myeloid-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRROS ITGAX MCTP1 CIITA PRKCD VASP	9.98e-06	169	129	6	7a7416fcbffcf57d19b477d9da091e04e3499524
ToppCell	facs-GAT-Fat-18m-Myeloid\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRROS ITGAX MCTP1 CIITA PRKCD VASP	9.98e-06	169	129	6	0e1a99cd77edcf32bcb513abd247b2b27409ac63
ToppCell	facs-GAT-Fat-18m-Myeloid-myeloid_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRROS ITGAX MCTP1 CIITA PRKCD VASP	9.98e-06	169	129	6	9bbad31ef03078f5aa456f2e1b17b49c91545ff0
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK20 ITGAX AGBL3 ELMO2 ARMC5 MCOLN3	1.43e-05	180	129	6	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	T_cells-Resident_memory_CD8+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	EPHB3 NBEAL1 PARP8 UBASH3A NACAD ABCB1	1.52e-05	182	129	6	111d434b89902ec11fb07f41b8ee1a98f3991b61
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PARP8 ABCB1 ZNF707 SLFN12L COMMD1 NMT2	1.57e-05	183	129	6	a492b3827d2c368d33a7a5118748beaf4d7f6797
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM\|lymph-node_spleen / Manually curated celltypes from each tissue	PARP8 ABCB1 EOMES SLFN12L FOXD1 MCOLN2	1.88e-05	189	129	6	e8ff2c4fd2481bfbc99a5a6f02e0db8c995b3a23
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MTSS1 NRROS ITGAX SERPINB8 SEMA6A MCOLN2	1.94e-05	190	129	6	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	NS-critical-d_0-4-Lymphoid\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PARP8 UBASH3A ABCB1 EOMES SLFN12L NMT2	1.94e-05	190	129	6	84f9f5ac29ff0f929a589b76efa61d4c570e76b0
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF MTSS1 NRROS ABCB1 MCTP1 SEMA6A	1.94e-05	190	129	6	a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCell	Control-Lymphoid-T_Cytotoxic\|Control / Disease state, Lineage and Cell class	PARP8 UBASH3A ABCB1 EOMES SLFN12L MCOLN2	2.00e-05	191	129	6	03b5c5e0941c3402ab3f48cbf3da2a027d110421
ToppCell	10x5'v1-week_14-16-Lymphocytic_T-T_NK-NK_T_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PARP8 APBB1 UBASH3A ABCB1 EOMES SLFN12L	2.06e-05	192	129	6	e836e3e4f419acdca106bc666c3c687f02da2fb3
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF MTSS1 ABCB1 MCTP1 SEMA6A EIF4G3	2.12e-05	193	129	6	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF MTSS1 ABCB1 MCTP1 SEMA6A EIF4G3	2.12e-05	193	129	6	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	367C-Lymphocytic-NK_cells\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LPCAT1 MTSS1 ITGAX ABCB1 EOMES SERPINE2	2.31e-05	196	129	6	c6fac4ead13834483e780188de7d417e5cf37611
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-gdT\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PARP8 UBASH3A ABCB1 EOMES SLFN12L MCOLN2	2.51e-05	199	129	6	a0f1e0d1aa175c2dcc5e744fff8b56ddda5293df
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	NLRP12 VWF COL6A6 GLB1L3	6.35e-05	74	129	4	0288a3f4eafbc359d01cde4ba58f946dd07c77cb
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	NLRP12 VWF COL6A6 GLB1L3	6.35e-05	74	129	4	57884ade66fe39398351685189df5efd7aea0aab
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	NLRP12 VWF COL6A6 GLB1L3	6.35e-05	74	129	4	13093139a75bfe11f6b032c9fb402efcc703551c
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	NLRP12 VWF COL6A6 GLB1L3	6.35e-05	74	129	4	7f7de9e8142d2435391ee965cee5628e412f0705
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	FOXO1 AGBL3 EOMES FAM120C GOLGA2	7.85e-05	151	129	5	4533bccc996395f74b16af939ce79b6fe253c073
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	FOXO1 AGBL3 EOMES FAM120C GOLGA2	7.85e-05	151	129	5	edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR CLGN SPTA1 NACAD TTC12	1.03e-04	160	129	5	9f24ee4fe1ba4590dce5dd4d43707fb007dca82f
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR CLGN SPTA1 NACAD TTC12	1.03e-04	160	129	5	3b3b99305558f5b49d050fb9b249007630ea9085
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PEG3 OCRL NACAD ANO3 TCTN1	1.03e-04	160	129	5	778faada072e3abfa76a9a06fd4885fb63de7902
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPCAT1 APBB1 GGT1 ABCB1 EML5	1.06e-04	161	129	5	140b3c7077947c541cff54f6754e2df968345f4d
ToppCell	facs-SCAT-Fat-24m-Epithelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B3 MYH6 CLGN OXCT1 HPX	1.12e-04	163	129	5	9fd2e495efb6c447cdc52efdb3b695cb2fa8b914
ToppCell	facs-SCAT-Fat-24m-Epithelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B3 MYH6 CLGN OXCT1 HPX	1.12e-04	163	129	5	ade2f59bca0ab0c4856202f980464f3287bddd24
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A5 UBASH3A NPM3 ABCB1 FAM120C	1.12e-04	163	129	5	a24db9d266a40f3bffe4f18d277bc269791b4560
ToppCell	facs-SCAT-Fat-24m-Epithelial-epithelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B3 MYH6 CLGN OXCT1 HPX	1.12e-04	163	129	5	aaf5d96bab1957c7bde84c741c7f2fb86ef41e8b
ToppCell	facs-MAT-Fat-3m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRROS ITGAX MCTP1 CIITA PRKCD	1.16e-04	164	129	5	b81498c3934e0d52bf0329dc745e02966f9d8613
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	VWF COL6A6 GLB1L3 MCOLN2	1.19e-04	87	129	4	cc89f4176b70d4eb5b5bf0ff2319b5f1f9e292c0
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	VWF COL6A6 GLB1L3 MCOLN2	1.19e-04	87	129	4	4274e04fa4aca85c2cefd8c5e03d0fa4a4f15536
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	VWF COL6A6 GLB1L3 MCOLN2	1.19e-04	87	129	4	54cbdf80aae3595eaace20c7cbac763282558213
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	VWF COL6A6 GLB1L3 MCOLN2	1.19e-04	87	129	4	8b1a0bd5d6af32afaca19e9c69f86530bbaa309d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA6B VWF ABCB1 SLFN12L MCTP1	1.23e-04	166	129	5	8e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	HAUS6 PARP8 UBASH3A TUBGCP6 LIG3	1.23e-04	166	129	5	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	Severe-Lymphoid-NK-innate_T\|Severe / Condition, Lineage, Cell class and cell subclass	PARP8 ABCB1 EOMES SLFN12L ADHFE1	1.23e-04	166	129	5	ee5ee75131fc0e22da0ceba3917f2104516af4b7
ToppCell	systemic_lupus_erythematosus-flare-Hematopoietic-Progen-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GLB1L3 APBB1 MSH2 NMT2 MGA	1.26e-04	167	129	5	b89ebd4906f52b1fe6b6540ec9339284e7caddd2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK-NK\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PARP8 ABCB1 EOMES SLFN12L ELF4	1.37e-04	170	129	5	9a47d03f7eea6299a836a0eb1e7c1252c03f76df
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK-NK-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PARP8 ABCB1 EOMES SLFN12L ELF4	1.37e-04	170	129	5	4252c0a335762508bd1f8f71c6e78a657d7df125
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PARP8 ABCB1 EOMES SLFN12L ELF4	1.37e-04	170	129	5	0aa11d8cb44403b6769860dac2d3b05da6fff79d
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A5 ITGAX TIAM2 SLF2 PRKCD	1.37e-04	170	129	5	8e774af244cfe787fa0ea2b6be0c3c2d00bfe4fc
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A5 ITGAX TIAM2 SLF2 PRKCD	1.37e-04	170	129	5	f5140eb9313c0d1bb31f8a761d9c062c56733a61
ToppCell	COVID-19_Convalescent-cDC\|COVID-19_Convalescent / Disease condition and Cell class	DNAH10 GLB1L3 MSH5 CIITA MCOLN2	1.41e-04	171	129	5	9ccaa9f1629818b0f63a5d930ee78c01e04cd98d
ToppCell	COVID-19_Convalescent-cDC-\|COVID-19_Convalescent / Disease condition and Cell class	DNAH10 GLB1L3 MSH5 CIITA MCOLN2	1.41e-04	171	129	5	fb5fae8b3adafcbb7c5618d887966b418355ed4d
ToppCell	Control-PLT_5\|Control / Disease Group and Platelet Clusters	NBEAL1 APBB1 RAB42 NPM3 MGA	1.45e-04	172	129	5	950d0a5b7908ee6ef8d30f123c9c7f7180dd4c26
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 SLC25A5 ADAMTS8 HPX TRIM63	1.45e-04	172	129	5	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 SLC25A5 ADAMTS8 HPX TRIM63	1.45e-04	172	129	5	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel\|Adult / Lineage, Cell type, age group and donor	VWF SPTA1 ABCB1 OXCT1 SEMA6A	1.45e-04	172	129	5	ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	UBASH3A ADHFE1 ACOT11 NMT2 MCOLN3	1.57e-04	175	129	5	a3f8c54c77bce9b035a4835945ab341909be4946
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PARP8 MSH2 UBASH3A AGBL3 SLFN12L	1.70e-04	178	129	5	31c847d7f7aa0f6d820afbb45d507992f5e9dc2f
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-SELL+_CD4_T\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP8B3 NRROS UBASH3A ABCB1 EOMES	1.79e-04	180	129	5	702673c0b7c5b0d22a6af3884374804b8c4d6254
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR CLGN UBASH3A NPM3 EOMES	1.79e-04	180	129	5	8cef63866c205df3825df84ce51fa61aa04ae491
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ATP8B3 TICRR AGBL3 OXCT1 MCOLN2	1.83e-04	181	129	5	e4dbc09f0210de465d8347969b301c22463a2b7d
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FOXO3 MARK3 SPTA1 HECTD4 BSG	1.88e-04	182	129	5	0c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCell	CF-Lymphoid-T_cell_&_NK_cell\|CF / Disease state, Lineage and Cell class	UBASH3A EOMES SLFN12L OXCT1 NMT2	1.88e-04	182	129	5	a8dfc59a3974e3433f434676b7c2749d0fcfc8b2
ToppCell	IPF-Lymphoid-ILC_A\|World / Disease state, Lineage and Cell class	PARP8 ABCB1 EOMES SLFN12L SERPINE2	1.88e-04	182	129	5	f91bb45baaec76cb3bb26eedbcf0709b2492e93f
ToppCell	(4)_B_cells-(4)_B_mantle\|(4)_B_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	MTSS1 NPM3 ABCB1 THRB TCTN1	1.93e-04	183	129	5	21b7fb6482eb1d5d31a4029e47e0992e8ddc8e2c
ToppCell	NS-critical-d_0-4-Lymphoid-Treg\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FOXO1 UBASH3A ABCB1 SLFN12L NMT2	1.93e-04	183	129	5	f478dfa231fc1b12ead0183cc9d22077cdf43d1f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 MYO7B SPTA1 ZFHX4 ANO3	1.98e-04	184	129	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 MYO7B SPTA1 ZFHX4 ANO3	1.98e-04	184	129	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 MYO7B SPTA1 ZFHX4 ANO3	1.98e-04	184	129	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF ABCB1 CASP12 MCTP1 CIITA	2.03e-04	185	129	5	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	Control-T_cells-CD8+_T_cells\|Control / group, cell type (main and fine annotations)	PARP8 UBASH3A ABCB1 EOMES SLFN12L	2.03e-04	185	129	5	02ab64c0166c0646d1d4c6ed110ef0b75a1096d0
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXO1 VWF TIAM2 SERPINE2 MCTP1	2.08e-04	186	129	5	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	Control-Endothelial-Endothelial-Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MTSS1 ABCB1 THRB SEMA6A EIF4G3	2.13e-04	187	129	5	ea9d34bcd3bd1f36745846309ede349773de501a
ToppCell	facs-Spleen-nan-3m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTSS1 NRROS CIITA HPX PRKCD	2.13e-04	187	129	5	3ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF ABCB1 MCTP1 CIITA SEMA6A	2.13e-04	187	129	5	dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLCZ1 VWF MCTP1 BSG FAM3C	2.13e-04	187	129	5	7170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PARP8 ABCB1 EOMES SLFN12L MCOLN2	2.19e-04	188	129	5	f8e6247bedc0ba494c5bb551539cb8ba5a97f557
ToppCell	COPD-Lymphoid-NK\|COPD / Disease state, Lineage and Cell class	LPCAT1 PARP8 MTSS1 ABCB1 SLFN12L	2.19e-04	188	129	5	c9a227c8e71b69929d43e9afb8306a95c8163778
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PARP8 ABCB1 EOMES SLFN12L MCOLN2	2.19e-04	188	129	5	8155bc5476fc333bedcc78c5ddcc8e4912536caa
ToppCell	COVID-19-kidney-T-cells-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TICRR PARP8 UBASH3A SLFN12L MCOLN2	2.19e-04	188	129	5	15484c05cb496cd98ed3f79a6134c5cec8f09a4d
ToppCell	(0)_NK_CD160pos\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PARP8 ABCB1 EOMES SLFN12L SERPINE2	2.24e-04	189	129	5	713991025bb92d38cb0507ff01fd91b48c8af45a
ToppCell	COVID-19-T_cells-CD8+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	PARP8 UBASH3A EOMES SLFN12L MCOLN2	2.24e-04	189	129	5	2c018d6120f65f0b2704b483bc9da1c0984872e3
ToppCell	NS-critical-d_0-4-Lymphoid-CTL\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PARP8 ABCB1 EOMES SLFN12L NMT2	2.24e-04	189	129	5	fb7572fb4c7c43886d57a025decad076f32a14c4
ToppCell	Control-Lymphoid-T_Cytotoxic\|World / Disease state, Lineage and Cell class	PARP8 UBASH3A ABCB1 EOMES SLFN12L	2.24e-04	189	129	5	ee4c1d930534788a7759d92dc8ff9c62e6ee2301
ToppCell	T_cells-GZMK+_CD8+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PARP8 UBASH3A EOMES SLFN12L MCOLN2	2.24e-04	189	129	5	e2ca075aedf7c370ab4ede6272254ffd06cbcdec
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PARP8 ABCB1 EOMES SLFN12L NMT2	2.30e-04	190	129	5	05e6af222d0ad97cb69f399a96c9038f9dd989b9
ToppCell	IPF-Lymphoid-T_Cytotoxic\|IPF / Disease state, Lineage and Cell class	PARP8 UBASH3A EOMES SLFN12L MCOLN2	2.30e-04	190	129	5	e5d0186bfb416a3eda76ac12b9379650afb6f409
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	HAUS6 SPSB1 MSH2 UCHL5 PRKDC	2.30e-04	190	129	5	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	Severe-Lymphoid-T-NK\|Severe / Condition, Lineage, Cell class and cell subclass	PARP8 ABCB1 EOMES SLFN12L SERPINE2	2.30e-04	190	129	5	60642de433f84fa2cecd796c3a1a4aab9219d3db
ToppCell	(1)_T_cells-(1)_T_CD8_gd\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	ITGAX ABCB1 EOMES SERPINE2 FAM3C	2.30e-04	190	129	5	268772d2adff34f7175b8474e95b67fd96dc1234
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	VWF ABCB1 MCTP1 CIITA SEMA6A	2.30e-04	190	129	5	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	COVID-19-Heart-T_cell\|Heart / Disease (COVID-19 only), tissue and cell type	SPTA1 PARP8 EOMES SLFN12L MCOLN2	2.30e-04	190	129	5	e6c3a6e01fef6c5b49f72661d4fb0414ba9046bf
ToppCell	NS-control-d_0-4-Lymphoid-CTL\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	UBASH3A ABCB1 EOMES SLFN12L MCOLN2	2.35e-04	191	129	5	27f2151da2f41015a979499f274ab1284a36189f
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_dendritic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SEMA6B ITGAX MCTP1 CIITA MCOLN2	2.35e-04	191	129	5	a5ee4d72b2311c8fa98ff73adc2499debb2014f1
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	HYOU1 ZNF224 CIITA PRKDC MCOLN2	2.35e-04	191	129	5	9454f642c3621370fa23640b631301346b300950
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A6 PEG3 SERPINE2 ZFHX4 SLF2	2.35e-04	191	129	5	7d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF ABCB1 MCTP1 CIITA SEMA6A	2.35e-04	191	129	5	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	COVID-19-lung-CD8+_T_cells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PARP8 UBASH3A EOMES SLFN12L MCOLN2	2.35e-04	191	129	5	543f8ae07cc2e6950c888115a5ca9445e3c0f618
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-cDC2\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRROS ITGAX MCTP1 CIITA MCOLN2	2.35e-04	191	129	5	a898153490fb9e8c4331c5dce63dbfb5185bccf2
ToppCell	droplet-Heart-nan-18m-Hematologic-erythrocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXO3 SPTA1 NACAD CELSR3	2.38e-04	104	129	4	060f0baca239ab89c18be40c1aa31931f4791b62
Drug	NSC78027	UBR5 HPX MCAT	1.76e-06	5	129	3	CID000151490
Disease	level of NAD-dependent protein deacetylase sirtuin-3, mitochondrial in blood serum	APBB1 HPX	1.81e-05	2	126	2	OBA_2044358
Disease	GTPase kras measurement	APBB1 HPX	1.81e-05	2	126	2	EFO_0020432
Disease	mucolipidosis type IV (implicated_via_orthology)	MCOLN3 MCOLN2	5.41e-05	3	126	2	DOID:0080490 (implicated_via_orthology)
Disease	head and neck carcinoma, lung cancer	MSH5 CLPTM1L	1.08e-04	4	126	2	MONDO_0002038, MONDO_0008903
Disease	PEELING SKIN SYNDROME	CHST8 SERPINB8	1.08e-04	4	126	2	C1849193
Disease	glycoproteinosis (implicated_via_orthology)	MCOLN3 MCOLN2	1.08e-04	4	126	2	DOID:3343 (implicated_via_orthology)
Disease	gallbladder carcinoma (is_implicated_in)	CLPTM1L UBR5	1.79e-04	5	126	2	DOID:4948 (is_implicated_in)
Disease	e3 ubiquitin-protein ligase RNF43 measurement	APBB1 HPX	1.79e-04	5	126	2	EFO_0021886
Disease	tumor necrosis factor ligand superfamily member 18 measurement	APBB1 HPX	2.68e-04	6	126	2	EFO_0020795
Disease	WAP four-disulfide core domain protein 3 measurement	NLRP12 SF3B4	2.68e-04	6	126	2	EFO_0802220
Disease	peeling skin syndrome (is_implicated_in)	CHST8 SERPINB8	2.68e-04	6	126	2	DOID:0060283 (is_implicated_in)
Disease	ficolin-1 measurement	APBB1 HPX	2.68e-04	6	126	2	EFO_0008134
Disease	muellerian-inhibiting factor measurement	APBB1 HPX	2.68e-04	6	126	2	EFO_0020584
Disease	common variable immunodeficiency	MSH5 EOMES	3.75e-04	7	126	2	MONDO_0015517
Disease	cytokine measurement	EPHB3 BBS2 ZNF224 CHST8 ABCB1 BBX MCTP1 SEMA6A	8.42e-04	461	126	8	EFO_0004873
Disease	Alcohol Use Disorder	CDK20 VWF GGT1	8.86e-04	44	126	3	C0001956
Disease	invasive ductal carcinoma (is_implicated_in)	ABCB1 UBR5	9.70e-04	11	126	2	DOID:3008 (is_implicated_in)
Disease	primary ovarian insufficiency (implicated_via_orthology)	MSH2 MSH5 NPM3	1.01e-03	46	126	3	DOID:5426 (implicated_via_orthology)
Disease	lung adenocarcinoma (is_implicated_in)	MSH2 CLPTM1L UBR5	1.21e-03	49	126	3	DOID:3910 (is_implicated_in)
Disease	Alzheimer disease, cognitive decline measurement, Cognitive impairment	SPSB1 TIAM2	1.37e-03	13	126	2	EFO_0007710, HP_0100543, MONDO_0004975
Disease	tumor necrosis factor measurement	APBB1 HPX	1.83e-03	15	126	2	EFO_0010834
Disease	Gastro-enteropancreatic neuroendocrine tumor	EOMES CIITA	1.83e-03	15	126	2	C2930967
Disease	renal cell carcinoma (is_marker_for)	VWF MSH2 ABCB1 BSG	2.25e-03	128	126	4	DOID:4450 (is_marker_for)
Disease	type 1 diabetes mellitus (biomarker_via_orthology)	VWF CASP12	2.95e-03	19	126	2	DOID:9744 (biomarker_via_orthology)
Disease	factor VIII measurement, Ischemic stroke	VWF HECTD4	2.95e-03	19	126	2	EFO_0004630, HP_0002140
Disease	lung non-small cell carcinoma (is_implicated_in)	MSH2 MSH5 ABCB1 CLPTM1L	3.03e-03	139	126	4	DOID:3908 (is_implicated_in)
Disease	corneal hysteresis	FOXO1 ADAMTS8	3.27e-03	20	126	2	EFO_0010066

Protein segments in the cluster

Peptide	Gene	Start	Entry
GFLSMFEVLNAASDV	TDRD5	171	Q8NAT2
PAAMLSDTDAGDAFA	EOMES	76	O95936
FLHDAFLSGAQVDMA	ACOX2	591	Q99424
DNTLMFEARFESGNL	AGBL3	166	Q8NEM8
GFVLAFEFMLSDLAE	CDK20	76	Q8IZL9
FFSLAALAEVAAMEN	BBX	896	Q8WY36
DALFELSGFSMEQAQ	CIITA	561	P33076
VADASMAAFYGADLQ	ADAMTS8	226	Q9UP79
MTDAAVSFAKDFLAG	SLC25A5	1	P05141
INSAFMTFVVLDADD	ACOT11	316	Q8WXI4
ALLSGSFAEAQMDLV	ARMC5	776	Q96C12
ASLLFGMRNSAASDE	APBB1	206	O00213
MEFATEEALAAFAQE	ATP8B3	676	O60423
MDALEGESFALSFSS	ARL2BP	1	Q9Y2Y0
GDIFDMLLTFTDFLA	ARL2BP	106	Q9Y2Y0
TFLDGIFDDLMENNV	CASP12	21	Q6UXS9
SESSQAEMEFSEGFL	ADAMTS13	1381	Q76LX8
AEMEFSEGFLKAQAS	ADAMTS13	1386	Q76LX8
NNSLSFFDLSELGMG	ANO3	866	Q9BYT9
SITNDMGFSDDFSLL	NBEAL1	1416	Q6ZS30
AQEAEELAASLGMAF	RAB42	141	Q8N4Z0
LDPESADMFDNGSFL	FOXD1	201	Q16676
SFELEMAQEGFSAVF	ITGAX	346	P20702
SDINDTGFFMNLEED	ABCB1	96	P08183
MDASLGNLFARSALD	FAM3C	31	Q92520
DLEEFLNQSFDMGVA	MAPK7	746	Q13164
FAFQTLGVMNEAADE	PARP8	536	Q8N3A8
SDLLEDMFSLFDESG	LPCAT1	381	Q8NF37
SAEFFADIALAPMEA	SLC25A3	171	Q00325
QDDFMGSAFLDLTQL	MCTP1	336	Q6DN14
SKGFDVFNALDLMEN	NMT2	446	O60551
DFLGFMDTDSALSEV	MGA	331	Q8IWI9
LFSLINGDDMFATFA	MCOLN3	451	Q8TDD5
MAAGTAAALAFLSQE	NPM3	1	O75607
LIDSMDQSAFAGFSF	PRKCD	651	Q05655
QPSDLIFEFASNGMD	ELF4	6	Q99607
DFSGNLDLEAFVLMA	GLB1L3	136	Q8NCI6
MGSEAAQLLEAADFA	HDDC3	1	Q8N4P3
AAGASDNDFMILTLV	ELAPOR1	461	Q6UXG2
FTFMESGVLVATAFD	OR51F1	116	A6NGY5
AAAFLDAFQKVADMA	MTSS1	51	O43312
FASFDLVAQMTAEDL	EPHB3	951	P54753
MVAFFNSAVASAEEE	GOLGA2P5	26	Q9HBQ8
LGITDMFDSSKANFA	SERPINE2	311	P07093
MEDGEFAQSLSDLLF	TUBGCP6	1526	Q96RT7
DLIAIADFAAGAMEN	NPEPPSL1	306	A6NEC2
AFDGDLVQEFDMTSA	LIG3	961	P49916
ISANFEALPFAMASD	HECTD4	2156	Q9Y4D8
MVAFFNSAVASAEEE	GOLGA2	736	Q08379
LDDNMQIRLSDFGFS	PHKG2	161	P15735
DFTDGRDAFMQSSEL	PEG3	686	Q9GZU2
QMAALCSRDDFLGSF	SMPD4	761	Q9NXE4
FFTDDFLAQLFMDTG	METTL6	221	Q8TCB7
EFAALVFAGAMEFAE	MCAT	156	Q8IVS2
ENERFFGDSAASMAI	HYOU1	76	Q9Y4L1
DLMDGDTLDFNFDNV	FOXO1	621	Q12778
IDLAGDIIQSMASFF	BBS2	561	Q9BXC9
MGFLKSALSFAEDEE	CYP3A43	111	Q9HB55
SADVTFATEFINMDG	ELMO2	111	Q96JJ3
AALFMSGVDTALFAN	FAM120C	821	Q9NX05
SEDKALMNGSESRFF	BSG	261	P35613
LDADMNIKIADFGFS	MARK3	186	P27448
SIASADMDFNQLEAF	COMMD1	61	Q8N668
AFIMDESNVLDSGFL	DYNC1H1	2991	Q14204
MADFLLETTVSDFGQ	HAUS6	636	Q7Z4H7
FSGNLDLEAFVLMAA	GLB1L2	111	Q8IW92
DGSFLMANADTLEDL	EML5	1061	Q05BV3
SLDFSLFQDTMAVGS	CELSR3	1871	Q9NYQ7
DIILLSEMFSDNFGQ	DNAH10	3776	Q8IVF4
FKGFSETLELADDMA	EIF4G3	1296	O43432
FEDILFGNNDMSASI	MSH2	131	P43246
DLIAIADFAAGAMEN	NPEPPS	306	P55786
LFSLVNGDDMFATFA	MCOLN2	456	Q8IZK6
VFLLDMSINGSEENF	COL6A6	231	A6NMZ7
AAFLLDASRNMGSAE	COL6A6	1966	A6NMZ7
SMAVAAEFRDSLGDF	PURB	76	Q96QR8
SFMALDFSGFGNLRD	NRROS	526	Q86YC3
AFVGQMKSDLFLDDS	PKD1	3391	P98161
SSFDFLKADDMGEIN	OR13C3	21	Q8NGS6
DSSFMEAIEFAQKGA	ADHFE1	116	Q8IWW8
AVSGQESLSEFFEML	NXT1	51	Q9UKK6
VEASDFEINGLDFMF	MSH5	456	O43196
ELMDADGLDFNFDSL	FOXO3	631	O43524
FDATTLDDNGTMLFF	HPX	56	P02790
AFFALSGLDMLDSLD	PGGT1B	51	P53609
SLDQMFDAEILGFST	SYS1	46	Q8N2H4
MAAGSDLLDEVFFNS	TAF4	1	O00268
SDSVLFLQEFGALMS	TRIM29	371	Q14134
CLASDAQFSDFLGSM	RIMS4	86	Q9H426
ATFGESLLSDMLDDF	PLCZ1	266	Q86YW0
FSTTLLGQFLEDMEA	SMG1	356	Q96Q15
TLDPAAADMFDNGSF	FOXE3	146	Q13461
GASFFSSDESFAMIR	OXCT1	376	P55809
SLSDVAAVFFNMGID	SLF2	851	Q8IX21
EALFAFSMEALELQG	SEMA4C	71	Q9C0C4
MATDSAFDVLGFTSE	MYH6	331	P13533
EILIFAFAGFDMISS	OR8U3	196	Q8NH85
SGLLGFEDNFSSMNL	OCRL	146	Q01968
LGMIDAFDEAKADFS	SERPINB8	286	P50452
LNVMADNFVFDGSSL	CLPTM1L	176	Q96KA5
GLLFISINAEFMDDD	CLGN	11	O14967
GKFESMEDDANFFLS	CHST8	346	Q9H2A9
GFENMDFFTLDLEHI	TRIM63	301	Q969Q1
EFSQSFDAAMKGLAL	UCHL5	116	Q9Y5K5
FDAAMKGLALSNSDV	UCHL5	121	Q9Y5K5
VMLDNFSSVAALGFC	ZNF707	36	Q96C28
FSDGMLFTATVTDFL	SEMA6B	186	Q9H3T3
FSTAMFLDSLASAGE	ZFHX4	161	Q86UP3
SSDLMESFGLLQAAS	TICRR	506	Q7Z2Z1
EEFKAFAADTGMNRS	WDFY3	1926	Q8IZQ1
ATAAEEFAFLMQSLG	RBP3	546	P10745
NIFAEDDFMTQEGTL	VWF	166	P04275
NETFLTQDEMESLFG	TIAM2	1131	Q8IVF5
EESNMEALAADFFNR	SLFN12L	191	Q6IEE8
SFLVALDMDDGTLSF	SPSB1	176	Q96BD6
FDMFALTRGSSLADQ	TOM1	366	O60784
NSGFLNDSLFLEEMS	SEMA6A	456	Q9H2E6
DAIFDLGMSLSSFNL	THRB	351	P10828
DENNFDTLMKTSDGF	TCTN1	171	Q2MV58
HEAFLLDLNSFGDSM	SPTA1	941	P02549
SGFMSNLIFEFCGAD	TXNDC8	101	Q6A555
MDSILADEAFFSVNS	PRKDC	541	P78527
MFPALGEASSDDDLF	WASHC2A	1171	Q641Q2
FDDDMDDIFSSGIQA	WASHC2A	1291	Q641Q2
FSDKEANTAMGLFTD	TTC12	396	Q9H892
DLMINSSQFSKEGDF	ZNF224	116	Q9NZL3
SQARKAMEEFFSDSG	UBR4	1391	Q5T4S7
SFDASDAAIEAMNGQ	SF3B4	151	Q15427
ADAVFSAMDLAFAID	UBR5	2591	O95071
EFAMTFATEASLLAG	UBASH3A	171	P57075
KEDAAQFAAGMASAL	VASP	96	P50552
PVSGILFNNEMDDFS	GGT1	411	P19440
LDGEDVSAFLNMNIF	NLRP12	486	P59046
SDLSITEGMDEAFAF	NACAD	366	O15069
VGFMASVFENLDASD	MYO7B	331	Q6PIF6