Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfatty acid binding

UGT1A9 NME2 UGT1A10 UGT1A8 UGT1A7

2.89e-0769415GO:0005504
GeneOntologyMolecularFunctionretinoic acid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.02e-0728414GO:0001972
GeneOntologyMolecularFunctionglucuronosyltransferase activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.65e-0735414GO:0015020
GeneOntologyMolecularFunctionmonocarboxylic acid binding

UGT1A9 NME2 UGT1A10 UGT1A8 UGT1A7

2.58e-06107415GO:0033293
GeneOntologyMolecularFunctionretinoid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.79e-0648414GO:0005501
GeneOntologyMolecularFunctionisoprenoid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.03e-0649414GO:0019840
GeneOntologyMolecularFunctionprotein kinase C binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.01e-0566414GO:0005080
GeneOntologyMolecularFunctionnucleoside diphosphate kinase activity

NME2P1 NME1 NME2

1.04e-0521413GO:0004550
GeneOntologyMolecularFunctionphosphotransferase activity, phosphate group as acceptor

NME2P1 NME1 NME2

8.11e-0541413GO:0016776
GeneOntologyMolecularFunctionnucleobase-containing compound kinase activity

NME2P1 NME1 NME2

1.22e-0447413GO:0019205
GeneOntologyMolecularFunctioncarboxylic acid binding

UGT1A9 NME2 UGT1A10 UGT1A8 UGT1A7

1.24e-04239415GO:0031406
GeneOntologyMolecularFunctionsteroid binding

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.57e-04133414GO:0005496
GeneOntologyMolecularFunctionorganic acid binding

UGT1A9 NME2 UGT1A10 UGT1A8 UGT1A7

1.65e-04254415GO:0043177
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.69e-04153414GO:0008194
GeneOntologyMolecularFunctionintermediate filament binding

NME1 NME2

4.25e-0415412GO:0019215
GeneOntologyMolecularFunctionhexosyltransferase activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.03e-04211414GO:0016758
GeneOntologyMolecularFunctionglycosyltransferase activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.82e-03288414GO:0016757
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing N-glycosyl compounds

SMUG1 BST1

3.21e-0341412GO:0016799
GeneOntologyMolecularFunctionprotein-folding chaperone binding

LRP2 FKBP1A HLA-F

4.38e-03161413GO:0051087
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

AIP FKBP1A

4.73e-0350412GO:0003755
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC38A7 TRPM4 SLC5A3

5.18e-03171413GO:0015081
GeneOntologyMolecularFunctiontransmembrane transporter binding

TSPAN18 FKBP1A SLC5A3

5.27e-03172413GO:0044325
GeneOntologyMolecularFunctioncis-trans isomerase activity

AIP FKBP1A

5.30e-0353412GO:0016859
GeneOntologyMolecularFunctionprotein homodimerization activity

UGT1A9 UGT1A10 UGT1A8 UGT1A7 SDS HLA-F

6.02e-03815416GO:0042803
GeneOntologyBiologicalProcessestrogen catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.05e-115404GO:0006711
GeneOntologyBiologicalProcessphenylpropanoid catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.81e-106404GO:0046271
GeneOntologyBiologicalProcesscoumarin catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.81e-106404GO:0046226
GeneOntologyBiologicalProcessflavone metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.81e-106404GO:0051552
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.52e-0910404GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.52e-0910404GO:0009804
GeneOntologyBiologicalProcessflavonoid metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.56e-0913404GO:0009812
GeneOntologyBiologicalProcessflavonoid glucuronidation

UGT1A9 UGT1A8 UGT1A7

6.74e-085403GO:0052696
GeneOntologyBiologicalProcesscellular glucuronidation

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.08e-0821404GO:0052695
GeneOntologyBiologicalProcesshormone catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.08e-0821404GO:0042447
GeneOntologyBiologicalProcessglucuronate metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.76e-0726404GO:0019585
GeneOntologyBiologicalProcessuronic acid metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.76e-0726404GO:0006063
GeneOntologyBiologicalProcesssteroid catabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.39e-0734404GO:0006706
GeneOntologyBiologicalProcesspyrimidine-containing compound metabolic process

DPYSL5 NME2P1 NME1 SMUG1 NME2

9.20e-0792405GO:0072527
GeneOntologyBiologicalProcessUTP biosynthetic process

NME2P1 NME1 NME2

1.10e-0611403GO:0006228
GeneOntologyBiologicalProcessxenobiotic glucuronidation

UGT1A9 UGT1A8 UGT1A7

1.47e-0612403GO:0052697
GeneOntologyBiologicalProcessUTP metabolic process

NME2P1 NME1 NME2

1.91e-0613403GO:0046051
GeneOntologyBiologicalProcessGTP biosynthetic process

NME2P1 NME1 NME2

1.91e-0613403GO:0006183
GeneOntologyBiologicalProcessCTP biosynthetic process

NME2P1 NME1 NME2

3.02e-0615403GO:0006241
GeneOntologyBiologicalProcessestrogen metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.07e-0652404GO:0008210
GeneOntologyBiologicalProcesspyrimidine ribonucleoside triphosphate biosynthetic process

NME2P1 NME1 NME2

3.72e-0616403GO:0009209
GeneOntologyBiologicalProcesspyrimidine nucleotide metabolic process

NME2P1 NME1 SMUG1 NME2

3.85e-0655404GO:0006220
GeneOntologyBiologicalProcessCTP metabolic process

NME2P1 NME1 NME2

4.51e-0617403GO:0046036
GeneOntologyBiologicalProcesspyrimidine ribonucleoside triphosphate metabolic process

NME2P1 NME1 NME2

6.41e-0619403GO:0009208
GeneOntologyBiologicalProcesspyrimidine nucleoside triphosphate biosynthetic process

NME2P1 NME1 NME2

7.53e-0620403GO:0009148
GeneOntologyBiologicalProcessxenobiotic metabolic process

UGT1A9 AIP UGT1A10 UGT1A8 UGT1A7

7.55e-06141405GO:0006805
GeneOntologyBiologicalProcesssecondary metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.51e-0667404GO:0019748
GeneOntologyBiologicalProcesspyrimidine ribonucleotide biosynthetic process

NME2P1 NME1 NME2

1.51e-0525403GO:0009220
GeneOntologyBiologicalProcesspyrimidine nucleoside triphosphate metabolic process

NME2P1 NME1 NME2

1.51e-0525403GO:0009147
GeneOntologyBiologicalProcessGTP metabolic process

NME2P1 NME1 NME2

2.38e-0529403GO:0046039
GeneOntologyBiologicalProcessretinoid metabolic process

LRP2 UGT1A9 UGT1A8 UGT1A7

2.63e-0589404GO:0001523
GeneOntologyBiologicalProcesspyrimidine deoxyribonucleotide metabolic process

NME1 SMUG1 NME2

2.65e-0530403GO:0009219
GeneOntologyBiologicalProcesspigment metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.26e-0594404GO:0042440
GeneOntologyBiologicalProcessditerpenoid metabolic process

LRP2 UGT1A9 UGT1A8 UGT1A7

3.26e-0594404GO:0016101
GeneOntologyBiologicalProcesspyrimidine nucleotide biosynthetic process

NME2P1 NME1 NME2

3.54e-0533403GO:0006221
GeneOntologyBiologicalProcesspyrimidine ribonucleotide metabolic process

NME2P1 NME1 NME2

3.88e-0534403GO:0009218
GeneOntologyBiologicalProcessterpenoid metabolic process

LRP2 UGT1A9 UGT1A8 UGT1A7

5.03e-05105404GO:0006721
GeneOntologyBiologicalProcessretinoic acid metabolic process

UGT1A9 UGT1A8 UGT1A7

6.35e-0540403GO:0042573
GeneOntologyBiologicalProcesscellular response to xenobiotic stimulus

UGT1A9 AIP UGT1A10 UGT1A8 UGT1A7

6.68e-05222405GO:0071466
GeneOntologyBiologicalProcessdTMP biosynthetic process

NME1 NME2

7.65e-057402GO:0006231
GeneOntologyBiologicalProcesspyrimidine deoxyribonucleoside monophosphate biosynthetic process

NME1 NME2

7.65e-057402GO:0009177
GeneOntologyBiologicalProcesspyrimidine-containing compound biosynthetic process

NME2P1 NME1 NME2

7.90e-0543403GO:0072528
GeneOntologyBiologicalProcesssteroid metabolic process

LRP2 UGT1A9 MBTPS2 UGT1A10 UGT1A8 UGT1A7

8.02e-05376406GO:0008202
GeneOntologyBiologicalProcessprotein maturation by protein folding

AIP FKBP1A

1.31e-049402GO:0022417
GeneOntologyBiologicalProcess2'-deoxyribonucleotide metabolic process

NME1 SMUG1 NME2

1.65e-0455403GO:0009394
GeneOntologyBiologicalProcessisoprenoid metabolic process

LRP2 UGT1A9 UGT1A8 UGT1A7

1.71e-04144404GO:0006720
GeneOntologyBiologicalProcessdeoxyribose phosphate metabolic process

NME1 SMUG1 NME2

1.74e-0456403GO:0019692
GeneOntologyBiologicalProcessdeoxyribonucleotide metabolic process

NME1 SMUG1 NME2

1.84e-0457403GO:0009262
GeneOntologyBiologicalProcesspyrimidine deoxyribonucleotide biosynthetic process

NME1 NME2

1.99e-0411402GO:0009221
GeneOntologyBiologicalProcessdeoxyribonucleoside monophosphate biosynthetic process

NME1 NME2

2.39e-0412402GO:0009157
GeneOntologyBiologicalProcessregulation of hormone levels

UGT1A9 TRPM4 HCFC1 UGT1A10 UGT1A8 UGT1A7 ITSN1

3.07e-04684407GO:0010817
GeneOntologyBiologicalProcessdTMP metabolic process

NME1 NME2

3.29e-0414402GO:0046073
GeneOntologyBiologicalProcessmonocarboxylic acid metabolic process

UGT1A9 ACSF3 ACAT2 UGT1A10 UGT1A8 UGT1A7 SDS

4.58e-04731407GO:0032787
GeneOntologyBiologicalProcessresponse to xenobiotic stimulus

UGT1A9 SRP68 AIP UGT1A10 UGT1A8 UGT1A7

4.86e-04525406GO:0009410
GeneOntologyBiologicalProcesspyrimidine deoxyribonucleoside monophosphate metabolic process

NME1 NME2

4.90e-0417402GO:0009176
GeneOntologyBiologicalProcess2'-deoxyribonucleotide biosynthetic process

NME1 NME2

6.14e-0419402GO:0009265
GeneOntologyBiologicalProcessdeoxyribonucleotide biosynthetic process

NME1 NME2

6.14e-0419402GO:0009263
GeneOntologyBiologicalProcessdeoxyribose phosphate biosynthetic process

NME1 NME2

6.14e-0419402GO:0046385
GeneOntologyBiologicalProcesspyrimidine nucleoside monophosphate biosynthetic process

NME1 NME2

6.14e-0419402GO:0009130
GeneOntologyBiologicalProcessliver development

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.19e-04202404GO:0001889
GeneOntologyBiologicalProcesshepaticobiliary system development

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.54e-04205404GO:0061008
GeneOntologyBiologicalProcesslipid catabolic process

UGT1A9 ACAT2 UGT1A10 UGT1A8 UGT1A7

8.20e-04382405GO:0016042
GeneOntologyBiologicalProcesspurine ribonucleotide biosynthetic process

NME2P1 ACSF3 NME1 NME2

1.04e-03232404GO:0009152
GeneOntologyBiologicalProcesspyrimidine nucleoside monophosphate metabolic process

NME1 NME2

1.16e-0326402GO:0009129
GeneOntologyBiologicalProcessribonucleotide biosynthetic process

NME2P1 ACSF3 NME1 NME2

1.31e-03247404GO:0009260
GeneOntologyBiologicalProcessribose phosphate biosynthetic process

NME2P1 ACSF3 NME1 NME2

1.43e-03253404GO:0046390
GeneOntologyBiologicalProcessneuron development

DPYSL5 LRP2 KIF3C NME1 NME2 TMEM132E ITSN1 GRK1 HLA-F

1.63e-031463409GO:0048666
GeneOntologyBiologicalProcesspurine ribonucleoside triphosphate biosynthetic process

NME2P1 NME1 NME2

1.78e-03124403GO:0009206
GeneOntologyBiologicalProcesspurine nucleoside triphosphate biosynthetic process

NME2P1 NME1 NME2

1.82e-03125403GO:0009145
GeneOntologyBiologicalProcessdeoxyribonucleoside monophosphate metabolic process

NME1 NME2

1.86e-0333402GO:0009162
GeneOntologyBiologicalProcessribonucleoside triphosphate biosynthetic process

NME2P1 NME1 NME2

2.04e-03130403GO:0009201
GeneOntologyBiologicalProcesspurine nucleotide biosynthetic process

NME2P1 ACSF3 NME1 NME2

2.07e-03280404GO:0006164
GeneOntologyBiologicalProcesshormone metabolic process

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.23e-03286404GO:0042445
GeneOntologyBiologicalProcesspurine-containing compound biosynthetic process

NME2P1 ACSF3 NME1 NME2

2.29e-03288404GO:0072522
GeneOntologyBiologicalProcessnucleoside triphosphate biosynthetic process

NME2P1 NME1 NME2

2.37e-03137403GO:0009142
GeneOntologyBiologicalProcessmetal ion transport

LRP2 SLC38A7 SLC41A2 TRPM4 TSPAN18 FKBP1A SLC5A3

2.83e-031000407GO:0030001
GeneOntologyBiologicalProcessregulation of T cell cytokine production

TRPM4 HLA-F

2.87e-0341402GO:0002724
GeneOntologyBiologicalProcessnucleotide biosynthetic process

NME2P1 ACSF3 NME1 NME2

3.31e-03319404GO:0009165
GeneOntologyBiologicalProcessnucleoside phosphate biosynthetic process

NME2P1 ACSF3 NME1 NME2

3.35e-03320404GO:1901293
GeneOntologyBiologicalProcessnucleobase-containing small molecule metabolic process

DPYSL5 NME2P1 ACSF3 NME1 SMUG1 NME2

3.38e-03767406GO:0055086
GeneOntologyBiologicalProcesscarboxylic acid metabolic process

UGT1A9 ACSF3 ACAT2 UGT1A10 UGT1A8 UGT1A7 SDS

3.42e-031035407GO:0019752
GeneOntologyBiologicalProcesspositive regulation of peptide hormone secretion

TRPM4 HCFC1 ITSN1

3.48e-03157403GO:0090277
GeneOntologyBiologicalProcesspyrimidine-containing compound catabolic process

DPYSL5 SMUG1

3.60e-0346402GO:0072529
GeneOntologyBiologicalProcesspositive regulation of peptide secretion

TRPM4 HCFC1 ITSN1

3.73e-03161403GO:0002793
GeneOntologyBiologicalProcessoxoacid metabolic process

UGT1A9 ACSF3 ACAT2 UGT1A10 UGT1A8 UGT1A7 SDS

3.86e-031058407GO:0043436
DomainUDPGT

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-0721404PS00375
DomainUDPGT

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-0721404PF00201
DomainUDP_glucos_trans

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-0721404IPR002213
DomainNDP_KINASES

NME2P1 NME1 NME2

7.58e-079403PS00469
DomainNDK

NME2P1 NME1 NME2

1.08e-0610403SM00562
DomainNDK

NME2P1 NME1 NME2

1.08e-0610403PF00334
DomainNucleoside_diP_kinase

NME2P1 NME1 NME2

1.98e-0612403IPR001564
DomainNucleoside_diP_kinase_AS

NME1 NME2

4.45e-055402IPR023005
DomainKelch_2

LCMT2 HCFC1

3.44e-0413402IPR011498
DomainKelch_2

LCMT2 HCFC1

3.44e-0413402PF07646
DomainFKBP_C

AIP FKBP1A

5.27e-0416402PF00254
DomainFKBP_PPIASE

AIP FKBP1A

5.27e-0416402PS50059
DomainPPIase_FKBP_dom

AIP FKBP1A

8.29e-0420402IPR001179
Domain-

LCMT2 HCFC1

4.74e-03484022.120.10.80
DomainKelch-typ_b-propeller

LCMT2 HCFC1

6.18e-0355402IPR015915
DomainVWA

VWA3A VIT

6.40e-0356402PF00092
PathwayREACTOME_DRUG_ADME

UGT1A9 NME1 NME2 UGT1A10 UGT1A8 UGT1A7

1.43e-07109326M45012
PathwayWP_ESTROGEN_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.55e-0722324MM15888
PathwayREACTOME_GLUCURONIDATION

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.25e-0724324MM14599
PathwayREACTOME_DRUG_ADME

UGT1A9 NME1 NME2 UGT1A10 UGT1A8 UGT1A7

2.41e-07119326MM15692
PathwayREACTOME_GLUCURONIDATION

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.67e-0725324M17787
PathwayWP_GLUCURONIDATION

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.67e-0725324MM15820
PathwayKEGG_ASCORBATE_AND_ALDARATE_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.67e-0725324M605
PathwayWP_GLUCURONIDATION

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.16e-0726324M39404
PathwayKEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.31e-0728324M19580
PathwayREACTOME_PARACETAMOL_ADME

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.70e-0639324MM15695
PathwayKEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.09e-0641324M7399
PathwayREACTOME_ASPIRIN_ADME

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.05e-0645324MM15694
PathwayWP_CODEINE_AND_MORPHINE_METABOLISM

UGT1A9 UGT1A10 UGT1A8

3.80e-0614323M39328
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.07e-0651324M17726
PathwayKEGG_STARCH_AND_SUCROSE_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.48e-0652324M14171
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.88e-0655324M14933
PathwayKEGG_RETINOL_METABOLISM

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.26e-0564324M9488
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.80e-0570324M16794
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.02e-0572324M9257
PathwayWP_METAPATHWAY_BIOTRANSFORMATION

UGT1A9 NAT14 UGT1A10 UGT1A8 UGT1A7

2.24e-05153325MM15844
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.58e-05107324MM14595
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.03e-04109324M18788
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

UGT1A9 AIP UGT1A10 UGT1A8 UGT1A7

1.24e-04219325MM14838
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

UGT1A9 AIP UGT1A10 UGT1A8 UGT1A7

1.26e-04220325M10320
PathwayREACTOME_ASPIRIN_ADME

UGT1A9 UGT1A8 UGT1A7

1.32e-0444323M45014
PathwayWP_ARYL_HYDROCARBON_RECEPTOR_PATHWAY_WP2873

UGT1A9 AIP UGT1A7

1.41e-0445323M39615
PathwayREACTOME_RIBAVIRIN_ADME

NME1 NME2

2.71e-0411322M46429
PathwayWP_2Q37_COPY_NUMBER_VARIATION_SYNDROME

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.09e-04145324M45512
PathwayWP_IRINOTECAN_PATHWAY

UGT1A9 UGT1A10

3.25e-0412322M39611
PathwayREACTOME_RIBAVIRIN_ADME

NME1 NME2

3.25e-0412322MM16638
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

NME1 NME2

5.15e-0415322MM1387
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

NME1 NME2

6.65e-0417322M5940
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

UGT1A9 NAT14 UGT1A10 UGT1A7

7.44e-04183324M39588
PathwayWP_TAMOXIFEN_METABOLISM

UGT1A10 UGT1A8

1.02e-0321322M39631
PathwayREACTOME_AZATHIOPRINE_ADME

NME1 NME2

1.23e-0323322M45013
PathwayWP_ESTROGEN_METABOLISM_WP5276

UGT1A10 UGT1A8

1.34e-0324322M46445
PathwayREACTOME_AZATHIOPRINE_ADME

NME1 NME2

1.69e-0327322MM15693
PathwayREACTOME_PARACETAMOL_ADME

UGT1A9 UGT1A10

1.95e-0329322M45015
PathwayREACTOME_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES

NME1 NME2

1.95e-0329322M27408
PathwayREACTOME_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES

NME1 NME2

1.95e-0329322MM15158
PathwayPID_CDC42_REG_PATHWAY

NME1 ITSN1

2.09e-0330322M83
PathwayWP_NRF2_PATHWAY

UGT1A9 UGT1A7 SLC5A3

3.93e-03141323M39454
PathwayREACTOME_METABOLISM_OF_STEROIDS

LRP2 MBTPS2 ACAT2

5.03e-03154323M27832
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

UGT1A9 AIP UGT1A7 SLC5A3

5.31e-03314324M39428
Pubmed

Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.49e-11641420297805
Pubmed

Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.49e-11641432527940
Pubmed

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.80e-1174148467709
Pubmed

Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.80e-1174148464825
Pubmed

Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.80e-11741427514509
Pubmed

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.16e-10841417179145
Pubmed

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.16e-10841420610558
Pubmed

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.16e-10841418052087
Pubmed

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-10941422511988
Pubmed

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.47e-101041423642732
Pubmed

UDP-glucuronosyltransferases.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.47e-101041411465080
Pubmed

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.47e-101041423371916
Pubmed

A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.47e-101041422558097
Pubmed

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.17e-101241419419973
Pubmed

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.17e-101241420308471
Pubmed

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.17e-101241411434514
Pubmed

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.18e-091341422085899
Pubmed

Genome-wide analysis of hepatic lipid content in extreme obesity.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.18e-091341425246029
Pubmed

Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1.

NME2P1 NME1 NME2

1.52e-0934138270257
Pubmed

Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.

UGT1A9 UGT1A10 UGT1A8

1.52e-09341329519853
Pubmed

Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region.

UGT1A9 UGT1A10 UGT1A8

1.52e-09341312847094
Pubmed

Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.65e-091441421646302
Pubmed

Human UDP-glucuronosyltransferases: metabolism, expression, and disease.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.65e-091441410836148
Pubmed

Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.65e-091441414672974
Pubmed

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.65e-09144149295054
Pubmed

Genome-wide association meta-analysis for total serum bilirubin levels.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.99e-091641419414484
Pubmed

Genome-wide association of serum bilirubin levels in Korean population.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.91e-091741420639394
Pubmed

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.02e-091841420056724
Pubmed

Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28.

UGT1A9 UGT1A10 UGT1A7

6.08e-09441317558305
Pubmed

A genome-wide assessment of variability in human serum metabolism.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.36e-091941423281178
Pubmed

Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele.

UGT1A9 UGT1A8 UGT1A7

1.52e-08541320565459
Pubmed

Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.

UGT1A9 UGT1A10 UGT1A8

1.52e-08541315057901
Pubmed

Genetic determinants influencing human serum metabolome among African Americans.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.74e-082441424625756
Pubmed

Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.

UGT1A9 UGT1A10 UGT1A8

1.27e-07941320732626
Pubmed

Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.

UGT1A9 UGT1A8 UGT1A7

2.49e-071141318695635
Pubmed

Human metabolic individuality in biomedical and pharmaceutical research.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.27e-075741421886157
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.14e-066641419898482
Pubmed

Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene.

UGT1A9 UGT1A7

1.36e-06241211677206
Pubmed

Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.

UGT1A9 UGT1A10

1.36e-06241222031623
Pubmed

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development.

NME1 NME2

1.36e-0624122509941
Pubmed

Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10.

UGT1A10 UGT1A8

1.36e-06241210497143
Pubmed

Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.

UGT1A9 UGT1A8

1.36e-06241218568343
Pubmed

Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes.

UGT1A10 UGT1A8

1.36e-06241217603215
Pubmed

UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.

UGT1A9 UGT1A7

1.36e-06241215709193
Pubmed

Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs.

UGT1A9 UGT1A7

1.36e-06241212944498
Pubmed

Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.

UGT1A9 UGT1A10

1.36e-06241225547628
Pubmed

Human brain nucleoside diphosphate kinase activity is decreased in Alzheimer's disease and Down syndrome.

NME1 NME2

1.36e-06241212200143
Pubmed

Nme gene family evolutionary history reveals pre-metazoan origins and high conservation between humans and the sea anemone, Nematostella vectensis.

NME1 NME2

1.36e-06241221085602
Pubmed

The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.

NME1 NME2

1.36e-06241232392889
Pubmed

Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon.

UGT1A10 UGT1A8

1.36e-0624129647757
Pubmed

Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.

NME1 NME2

1.36e-06241235259022
Pubmed

Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.

UGT1A9 UGT1A7

1.36e-06241217529886
Pubmed

Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396.

NME2P1 NME2

1.36e-0624127488060
Pubmed

A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential.

NME1 NME2

1.36e-0624128245015
Pubmed

Expression of cell surface NM23 proteins of human leukemia cell lines of various cellular lineage and differentiation stages.

NME1 NME2

1.36e-06241212007505
Pubmed

How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?

UGT1A9 UGT1A10

1.36e-06241220089735
Pubmed

Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases.

NME1 NME2

1.36e-06241212972261
Pubmed

Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues.

UGT1A10 UGT1A8

1.36e-06241211901093
Pubmed

Organization and expression of mouse nm23-M1 gene. Comparison with nm23-M2 expression.

NME1 NME2

4.06e-06341210452942
Pubmed

Histidine kinase NME1 and NME2 are involved in TGF-β1-induced HSC activation and CCl4-induced liver fibrosis.

NME1 NME2

4.06e-06341232860079
Pubmed

UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients.

UGT1A9 UGT1A8

4.06e-06341219225446
Pubmed

Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis.

NME1 NME2

4.06e-06341225748386
Pubmed

Nm23/NDP kinases in human male germ cells: role in spermiogenesis and sperm motility?

NME1 NME2

4.06e-06341214499630
Pubmed

[Influence of genetic polymorphisms in UGT1A1, UGT1A7 and UGT1A9 on the pharmacokynetics of irinotecan, SN-38 and SN-38G].

UGT1A9 UGT1A7

4.06e-06341223789755
Pubmed

Novel roles of NM23 proteins in skin homeostasis, repair and disease.

NME1 NME2

4.06e-06341216862176
Pubmed

Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis.

NME1 NME2

4.06e-06341211042679
Pubmed

Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma.

NME1 NME2

4.06e-06341233024267
Pubmed

Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.

UGT1A9 UGT1A7

4.06e-06341219364970
Pubmed

The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function.

NME1 NME2

4.06e-06341219805292
Pubmed

Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer.

UGT1A9 UGT1A7

4.06e-06341217406868
Pubmed

Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis.

NME1 NME2

4.06e-0634128392752
Pubmed

Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate.

NME1 NME2

4.06e-06341228767310
Pubmed

Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis.

NME1 NME2

4.06e-06341222080566
Pubmed

Association of nucleoside diphosphate kinase nm23-H2 with human telomeres.

NME1 NME2

4.06e-0634129480811
Pubmed

NME proteins regulate class switch recombination.

NME1 NME2

4.06e-06341230411342
Pubmed

Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin.

UGT1A9 UGT1A7

4.06e-06341216636344
Pubmed

Nm23-M2/NDP kinase B induces endogenous c-myc and nm23-M1/NDP kinase A overexpression in BAF3 cells. Both NDP kinases protect the cells from oxidative stress-induced death.

NME1 NME2

4.06e-06341215530864
Pubmed

Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.

UGT1A9 UGT1A10

4.06e-06341220007669
Pubmed

nm23 regulates decidualization through the PI3K-Akt-mTOR signaling pathways in mice and humans.

NME1 NME2

4.06e-06341227604954
Pubmed

Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1α and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.

UGT1A9 UGT1A8

4.06e-06341223721685
Pubmed

Increased lung metastasis in transgenic NM23-Null/SV40 mice with hepatocellular carcinoma.

NME1 NME2

4.06e-06341215928304
Pubmed

Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.

NME1 NME2

4.06e-0634121851158
Pubmed

Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis.

NME1 NME2

4.06e-0634129488696
Pubmed

Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites.

UGT1A10 UGT1A8

4.06e-06341219244109
Pubmed

Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene.

NME1 NME2

4.06e-06341211277919
Pubmed

mRNA levels of nm23 in murine ascites hepatoma (H22) clones with different lymphatic metastatic potential.

NME1 NME2

4.06e-0634128543593
Pubmed

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions.

UGT1A8 UGT1A7

4.06e-06341219996319
Pubmed

Structural comparison of highly similar nucleoside-diphosphate kinases: Molecular explanation of distinct membrane-binding behavior.

NME1 NME2

4.06e-06341225010650
Pubmed

Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9.

UGT1A9 UGT1A8

4.06e-06341226247833
Pubmed

Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.

UGT1A9 UGT1A8

4.06e-06341216397224
Pubmed

Transglutaminase 2 and nucleoside diphosphate kinase activity are correlated in epithelial membranes and are abnormal in cystic fibrosis.

NME1 NME2

4.06e-06341219619546
Pubmed

Identification of novel mRNA transcripts of the nm23-M1 gene that are modulated during mouse embryo development and are differently expressed in adult murine tissues.

NME1 NME2

4.06e-0634129881672
Pubmed

Delayed processing of bone marrow samples reveals a prognostic pattern of NME mRNA expression in cytogenetically normal acute myeloid leukemia.

NME1 NME2

4.06e-06341222421058
Pubmed

NM23 proteins: innocent bystanders or local energy boosters for CFTR?

NME1 NME2

4.06e-06341229251738
Pubmed

The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers.

UGT1A9 UGT1A8

4.06e-06341217339869
Pubmed

The N-myc and c-myc downstream pathways include the chromosome 17q genes nm23-H1 and nm23-H2.

NME1 NME2

4.06e-06341211960382
Pubmed

Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations.

UGT1A9 UGT1A7

4.06e-06341224453052
Pubmed

Phorbol 12-myristate 13-acetate enhances nm23 gene expression in murine melanocytes but not in syngeneic B16-BL6 melanoma variants.

NME1 NME2

4.06e-0634128600152
Pubmed

Deoxyribonucleotide metabolism, mutagenesis and cancer.

NME1 NME2

8.12e-06441226299592
Pubmed

Influence of uridine diphosphate (UDP)-glucuronosyltransferases and ABCC2 genetic polymorphisms on the pharmacokinetics of mycophenolic acid and its metabolites in Chinese renal transplant recipients.

UGT1A9 UGT1A8

8.12e-06441218946804
InteractionUGT1A7 interactions

UGT1A9 UGT1A10 UGT1A8 UGT1A7 HLA-F

1.05e-0757415int:UGT1A7
InteractionUGT1A9 interactions

UGT1A9 UGT1A10 UGT1A7

2.20e-0613413int:UGT1A9
InteractionUGT1A8 interactions

UGT1A8 UGT1A7

1.21e-053412int:UGT1A8
InteractionNME1-NME2 interactions

NME2P1 NME1 NME2 FKBP1A

3.94e-0594414int:NME1-NME2
InteractionUGT1A10 interactions

UGT1A9 UGT1A10 UGT1A7

4.09e-0533413int:UGT1A10
Cytoband2q37

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.69e-08314142q37
CytobandEnsembl 112 genes in cytogenetic band chr2q37

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.02e-05226414chr2q37
Cytoband17q21.3

NME1 NME2

9.26e-051641217q21.3
CytobandEnsembl 112 genes in cytogenetic band chr12q24

NME2P1 VSIG10 DDX55 SDS

5.12e-04415414chr12q24
Cytoband12q24.31

NME2P1 DDX55

2.35e-038041212q24.31
CytobandEnsembl 112 genes in cytogenetic band chr2p23

DPYSL5 KIF3C

7.90e-03149412chr2p23
GeneFamilyUDP glucuronosyltransferases

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.61e-0732284363
GeneFamilyNME/NM23 family

NME1 NME2

8.27e-059282961
GeneFamilyFKBP prolyl isomerases

AIP FKBP1A

3.48e-0418282910
GeneFamilySolute carriers

SLC38A7 SLC41A2 SLC22A20P SLC5A3

3.03e-03395284752
CoexpressionWAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR

UGT1A9 UGT1A10 UGT1A8 UGT1A7 ITSN1

4.14e-06154415MM1313
Drugnaringenin chalcone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.52e-115414ctd:C027329
Druganthrarobin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.52e-115414ctd:C032186
DrugWoodward's reagent K

UGT1A9 BST1 UGT1A10 UGT1A8 UGT1A7 GRK1

1.35e-1043416CID000077804
Drug1,2,5,8-tetrahydroxy anthraquinone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.35e-106414ctd:C543211
Drugalloin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.35e-106414ctd:C006457
Drug2',5'-dihydroxychalcone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.35e-106414ctd:C107497
Drug2',4'-dihydroxychalcone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.15e-107414ctd:C059354
Drug1,4-dihydroxyanthraquinone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.30e-108414ctd:C034890
DrugAC1MRQNQ

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.13e-099414CID003522271
DrugDHPASiU

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.13e-099414CID000197602
DrugChebi:32663

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.13e-099414CID005460873
Drug3-iodophenol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.13e-099414CID000012272
DrugAC1L4J7U

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.13e-099414CID000186631
Drug2,6-dihydroxyanthraquinone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.89e-0910414ctd:C034889
Drug4-nitrophenyl)imidazole

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.96e-0911414CID000123155
DrugAC1O5XMV

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.96e-0911414CID006442661
DrugN-OH-DABZ

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.43e-0912414CID000051366
Drug1-O-beta-D-glucopyranosyl-D-mannitol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.43e-0912414CID000088735
Drug4-hydroxyestrone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.43e-0912414ctd:C026418
Drug2,4,6-TCB

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.43e-0912414CID000037247
Drug7,7,7-triphenylheptanoic acid

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.43e-0912414CID000276709
Drugnonanoyl-N-methylglucamide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.43e-0912414CID000160090
Drug2-hydroxyestrone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.39e-0913414ctd:C024980
Drugtritanol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.39e-0913414CID000006457
Drug5-azido-UDP-glucuronic acid

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.39e-0913414CID003081279
Drugcotinine-N-glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.39e-0913414CID000000411
Drugalizarin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.39e-0913414ctd:C010078
Drugpropranolol glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.94e-0914414CID000119515
DrugPCB-61

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.94e-0914414CID000036401
Drug2,2',3,5,5'-pentachlorobiphenyl

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.22e-0815414CID000040469
Drugcoumarin-3-carboxylic acid

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.22e-0815414CID000010752
Drugbergamottin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.22e-0815414ctd:C068337
Drugsulforaphane nitrile

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.22e-0815414CID000543743
Drugafloqualone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.22e-0815414CID000002040
Drugnaphthyl sulphate

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.22e-0815414CID000114775
Drugquercetin-3,4'-diglucoside

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.62e-0816414CID005320835
Drug1'-hydroxyestragole

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.62e-0816414CID000040003
Drugbilirubin-phosphate

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.62e-0816414CID005497144
Drug7,3'-dihydroxy-4'-methoxyisoflavone

UGT1A9 NME1 UGT1A10 UGT1A8 UGT1A7

1.91e-0846415ctd:C121707
Drug3 beta,5 alpha,25R)- 3-hydroxyspirostan-12-one

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.12e-0817414CID000003573
Drug6-hydroxychrysene

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.12e-0817414CID000037766
Drug2-vanillin

UGT1A10 UGT1A8 UGT1A7

2.17e-084413ctd:C060843
Drughydratropic acid

UGT1A10 UGT1A8 UGT1A7

2.17e-084413ctd:C013025
Drugdiphenylacetic acid

UGT1A10 UGT1A8 UGT1A7

2.17e-084413ctd:C037760
Drugethyl-beta-D-6-glucosiduronic acid

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.72e-0818414CID000152226
DrugBr 2

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.72e-0818414CID003060900
DrugSureCN12722713

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.72e-0818414CID005488034
Drug2,3,7-trichlorodibenzo-p-dioxin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.72e-0818414CID000036614
DrugApApG

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.72e-0818414CID003081975
DrugC1 11-32

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.72e-0818414CID000443077
DrugC11131

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.72e-0818414CID000443076
Drugalmokalant

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.44e-0819414CID003033962
Drug9-OH-risperidone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.44e-0819414CID000475100
Drug5alpha-spirostan-3beta-ol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

3.44e-0819414CID000091433
Drugbropirimine

UGT1A9 AIP UGT1A10 UGT1A8 UGT1A7

3.59e-0852415CID000065457
Drugtectochrysin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.29e-0820414CID005281954
DrugAC1L1OBF

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.29e-0820414CID000032736
Drug4'-hydroxydiclofenac

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.29e-0820414CID000116545
Drugentacapone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.29e-0820414ctd:C071192
Drugestriol-16-glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.30e-0821414CID000122281
Drugdulcin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.30e-0821414CID000009013
DrugBenzamidoxime hydrochloride

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.30e-0821414CID000069186
Drugisovaleric acid

UGT1A10 UGT1A8 UGT1A7

5.41e-085413ctd:C008216
Drugbiphenylylacetic acid

UGT1A10 UGT1A8 UGT1A7

5.41e-085413ctd:C012776
Drugamonafide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.46e-0822414CID000050515
Drugplumbagin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.46e-0822414ctd:C014758
DrugN-methylpiperazine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.46e-0822414CID000053167
Drugamidoxime

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.82e-0823414CID000465967
Drugestradiol-3-glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.82e-0823414CID000066651
Drugphenanthridine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.82e-0823414CID000009189
DrugAS-3201

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.37e-0824414CID000153948
Drug3-phenylpropionic acid

UGT1A10 UGT1A8 UGT1A7

1.08e-076413ctd:C035253
DrugIndoprofen

UGT1A10 UGT1A8 UGT1A7

1.08e-076413ctd:D007216
Drug5-MOP

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.11e-0725414CID000002355
DrugHymecromone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.11e-0725414ctd:D006923
DrugAzMC

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.11e-0725414CID000064986
DrugN-acetylbenzidine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.11e-0725414CID000018787
Drug5,6-benzoquinoline

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.11e-0725414CID000006796
DrugN-phenylmaleimide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.11e-0725414CID000013662
DrugThymol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.31e-0726414ctd:D013943
DrugScopoletin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.54e-0727414ctd:D012603
DrugDiMeIQx

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.54e-0727414CID000104739
Druglicochalcone A

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.54e-0727414ctd:C070840
Drugdiflunisal

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.54e-0727414CID000003059
DrugN-hydroxy-4-aminobiphenyl

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.80e-0728414CID000081261
DrugCARMINE

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.80e-0728414CID000014749
Drugerucin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.80e-0728414CID000078160
DrugH-Ni

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.80e-0728414CID000445665
DrugAC1L1JAL

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0729414CID000004954
Drug7-hydroxy-4-trifluoromethylcoumarin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0729414CID005375667
Drugtrans-3'-hydroxycotinine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0729414CID000000414
Drug7-hydroxycoumarin glucuronide

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0729414CID000125641
Drugiberin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0729414CID000010455
Drug2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.08e-0729414ctd:C060533
Drug7-hydroxycoumarin

UGT1A9 UGT1A10 UGT1A8 UGT1A7 SDS

2.31e-0775415CID005281426
Drugtolcapone

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.40e-0730414CID004659569
Drugparicalcitol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.40e-0730414CID005281104
DrugAC1L9E0Q

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.40e-0730414CID000443095
Drugdihydroartemisinin

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.40e-0730414CID000107770
Drug4-ethylphenol

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.75e-0731414CID000031242
DiseaseN-acetyl-4-chlorophenylalanine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.60e-115414EFO_0801060
Disease5-hydroxyindole sulfate measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.60e-115414EFO_0800085
Diseasenuclear receptor subfamily 1 group D member 2 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.60e-115414EFO_0801853
DiseaseX-21339 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.12e-107414EFO_0800808
DiseaseX-11793--oxidized bilirubin measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0021260
DiseaseSuccinimide measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0022118
DiseaseX-24849 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0800909
DiseaseX-11530 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0021249
Diseasesulfate of piperine metabolite C16H19NO3 (2) measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0801034
Diseasecholelithiasis, bilirubin measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0004570, EFO_0004799
DiseaseX-11522 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0800696
DiseaseX-10458 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0800692
Diseaseserum N-desmethylclozapine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0600043
Diseaseplasma clozapine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0600038
Diseasemembrane-associated progesterone receptor component 1 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0802740
DiseaseX-16946 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.24e-108414EFO_0800766
DiseaseX-11442 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.02e-109414EFO_0021236
DiseaseX-11441 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.02e-109414EFO_0021235
Diseasecirculating cell free DNA measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.02e-109414EFO_0004739
Diseasetestis-specific chromodomain protein Y 1 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.02e-109414EFO_0802127
Diseasesulfate of piperine metabolite C18H21NO3 (3) measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.02e-109414EFO_0801037
Diseasesulfate of piperine metabolite C18H21NO3 (1) measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.02e-109414EFO_0801036
Diseasebilirubin measurement, response to xenobiotic stimulus

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.02e-109414EFO_0004570, GO_0009410
DiseaseX-11880 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.02e-109414EFO_0800698
Diseaseprotein-tyrosine kinase 6 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

4.02e-109414EFO_0020691
DiseaseX-21448 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.69e-1010414EFO_0800816
DiseaseUDP-glucuronosyltransferase 1-6 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.69e-1010414EFO_0802185
Diseasebilirubin measurement, response to tenofovir

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.69e-1010414EFO_0004570, EFO_0009279
DiseaseX-23974 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.69e-1010414EFO_0800867
Diseasepregnenetriol sulfate measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-0911414EFO_0800586
Diseaseplasma N-desmethylclozapine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-0911414EFO_0600039
Diseaseinsomnia, bilirubin measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-0911414EFO_0004570, EFO_0004698
Diseasehistidine betaine (hercynine) measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-0911414EFO_0800972
Diseasealdosterone measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-0911414EFO_0010219
DiseaseX-21796 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.05e-0911414EFO_0800825
Diseasebiliverdin measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.57e-0912414EFO_0021033
Diseasep-cresol glucuronide measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.57e-0912414EFO_0800079
Diseaseretinol dehydrogenase 16 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.27e-0913414EFO_0802007
Diseasepregnenetriol disulfate measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.27e-0913414EFO_0800587
Diseaseblood 4-oxo-retinoic acid measurement

UGT1A9 UGT1A10 UGT1A8

2.49e-093413EFO_0022216
Diseaseindole-3-carboxylate measurement

UGT1A9 UGT1A10 UGT1A8

2.49e-093413EFO_0800043
DiseaseX-21441 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.53e-0917414EFO_0800814
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.53e-0917414EFO_0004611, EFO_0007800
Diseaseangiopoietin-related protein 1 measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

9.68e-0918414EFO_0801382
Diseasetissue factor measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.89e-0821414EFO_0010623
Disease3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) measurement

UGT1A9 UGT1A10 UGT1A8

4.97e-086413EFO_0800566
Diseaseneuroblastoma, cutaneous melanoma

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.41e-0828414EFO_0000389, EFO_0000621
Diseasexanthurenate measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

7.43e-0829414EFO_0010551
Diseaseresponse to dolutegravir

UGT1A9 UGT1A10 UGT1A8 UGT1A7

8.56e-0830414EFO_0600017
Diseasevitamin D deficiency

UGT1A9 UGT1A10 UGT1A8 UGT1A7

2.05e-0737414EFO_0003762
Diseaseindoleacetate measurement

UGT1A9 UGT1A10 UGT1A8

2.97e-0710413EFO_0021015
Diseasevitamin D measurement, COVID-19

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.49e-0749414EFO_0004631, MONDO_0100096
DiseaseX-24588 measurement

UGT1A9 UGT1A10 UGT1A8

7.05e-0713413EFO_0800898
Diseaseurate measurement, spine bone mineral density

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.29e-0658414EFO_0004531, EFO_0007701
Diseasethyroxine measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.44e-0683414EFO_0005130
Diseasehormone measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.71e-0684414EFO_0004730
Diseasecholelithiasis

UGT1A9 UGT1A10 UGT1A8 UGT1A7

6.87e-0688414EFO_0004799
Diseasegallstones

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.55e-05108414EFO_0004210
Diseaseteratoma (is_implicated_in)

NME1 NME2

1.88e-055412DOID:3307 (is_implicated_in)
Diseasenucleoside diphosphate kinase B measurement

NME1 NME2

3.94e-057412EFO_0020615
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

UGT1A9 UGT1A10 UGT1A8 UGT1A7

5.19e-05147414DOID:9352 (biomarker_via_orthology)
Diseasedodecanedioate measurement

UGT1A10 UGT1A8

1.23e-0412412EFO_0021054
Diseasetemporal horn of lateral ventricle volume measurement

QRFPR UGT1A10 UGT1A8

1.39e-0472413EFO_0010333
Diseasemetabolite measurement

UGT1A9 BST1 UGT1A10 UGT1A8 UGT1A7

1.03e-03560415EFO_0004725
Diseasevitamin D measurement

UGT1A9 UGT1A10 UGT1A8 UGT1A7

1.20e-03336414EFO_0004631

Protein segments in the cluster

PeptideGeneStartEntry
RIEIWVMHEIGGPNV

BST1

221

Q10588
VGWGIPAIMVAITVS

ADGRG4

2856

Q8IZF6
DVAVIGVPDMTWGQR

ACSF3

501

Q4G176
GVPDMTWGQRVTAVV

ACSF3

506

Q4G176
VIRGWEEGVAQMSVG

FKBP1A

56

P62942
PVWETIVCTMREGEI

AIP

71

O00170
LGVVWLVAVIVGSPM

QRFPR

166

Q96P65
GAVVTGAVVAAVMWR

HLA-F

316

P30511
GPVVAMVWEGLNVVK

NME2

71

P22392
GGWVPLVMDDVKVAT

HCFC1

271

P51610
DVMARGIDIPEVNWV

DDX55

326

Q8NHQ9
TMQGTWVEPELRGVI

KIF3C

106

O14782
VVPVAVAAWGVGGML

NAT14

166

Q8WUY8
VMQPDGIAVDWVGRH

LRP2

4141

P98164
DILEVVGGWPVAMDR

MMEL1

191

Q495T6
IQPGDIVMVKGEWVD

ITSN1

761

Q15811
MIPVSLVVVVVGGWT

MBTPS2

1

O43462
IPWQEEMIETGIFGE

GRK1

516

Q15835
LVVEWMPTRGRTVAG

SLC22A20P

211

A6NK97
QEVGWGDVPVIAMET

SDS

181

P20132
VQDRMSVIWERGVVG

DPYSL5

351

Q9BPU6
QVVTMLGPDWLVEVT

TMEM132E

611

Q6IEE7
GPVVAMVWEGLNVVK

NME1

71

P15531
GPVVAMVWEGLNVVK

NME2P1

56

O60361
PEVKTWGGVVTAAMV

SLC38A7

271

Q9NVC3
ISIAWVPIIVEMQGG

SLC5A3

421

P53794
WEPVITAMVISSIGG

SLC41A2

381

Q96JW4
ATMSEVEWRGRTVPV

SRP68

291

Q9UHB9
RGHEVVVVMPEVSWQ

UGT1A10

51

Q9HAW8
VSWSQVGVEPSIMGI

ACAT2

281

Q9BWD1
RSGAPNVVVVMVDGW

VIT

391

Q6UXI7
NVVVVMVDGWPTDKV

VIT

396

Q6UXI7
RGHEVVVVMPEVSWQ

UGT1A9

51

O60656
VPFGEVSMVRDWLGI

SMUG1

96

Q53HV7
VSMVRDWLGIVGPVL

SMUG1

101

Q53HV7
GIWVMVDPTGFREIV

TSPAN18

31

Q96SJ8
DSPVGVREMEIWLSV

VSIG10

391

Q8N0Z9
VGTMAWVRIPVEGEV

LCMT2

516

O60294
CVTAGTPEVWVQVRM

PVRIG

36

Q6DKI7
TKVVAMGVAPWGVVR

TRPM4

181

Q8TD43
RGHEVVVVMPEVSWQ

UGT1A7

51

Q9HAW7
GVVRHIQWTPREMEV

VWA3A

911

A6NCI4
RGHEVVVVMPEVSWQ

UGT1A8

51

Q9HAW9
MKGIGWVPIDSLEVV

NEB

3391

P20929