Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglutamine N-acyltransferase activity

GLYATL1 GLYATL1B

4.32e-062422GO:0047946
GeneOntologyMolecularFunctionglycine N-acyltransferase activity

GLYATL1 GLYATL1B

4.30e-055422GO:0047961
GeneOntologyMolecularFunctionWnt receptor activity

FZD4 PKD1

5.76e-0417422GO:0042813
DomainGOLGA6L

GOLGA6L10 GOLGA6L9 GOLGA6L19 GOLGA6L4

4.00e-106444IPR026737
DomainGOLGA2L5

GOLGA6L10 GOLGA6L9 GOLGA6L19 GOLGA6L4

8.00e-0818444PF15070
DomainGolgin_A

GOLGA6L10 GOLGA6L9 GOLGA6L19 GOLGA6L4

8.00e-0818444IPR024858
DomainGrowth_fac_rcpt_

MEGF6 MEGF8 UMODL1 GPR179

4.90e-04156444IPR009030
DomainEMI_domain

MEGF6 UMODL1

6.37e-0416442IPR011489
DomainEMI

MEGF6 UMODL1

7.21e-0417442PS51041
DomainEGF_CA

MEGF6 MEGF8 UMODL1

1.09e-0386443PF07645
DomainEGF_Ca-bd_CS

MEGF6 MEGF8 UMODL1

1.54e-0397443IPR018097
DomainEGF_CA

MEGF6 MEGF8 UMODL1

1.63e-0399443PS01187
DomainASX_HYDROXYL

MEGF6 MEGF8 UMODL1

1.68e-03100443PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

MEGF6 MEGF8 UMODL1

1.99e-03106443IPR000152
DomainEGF

MEGF6 MEGF8 UMODL1 GPR179

2.24e-03235444SM00181
DomainEGF_CA

MEGF6 MEGF8 UMODL1

2.96e-03122443SM00179
DomainLaminin_EGF

MEGF6 MEGF8

3.07e-0335442PF00053
DomainEGF_Lam

MEGF6 MEGF8

3.07e-0335442SM00180
DomainEGF-like_Ca-bd_dom

MEGF6 MEGF8 UMODL1

3.10e-03124443IPR001881
DomainLaminin_EGF

MEGF6 MEGF8

3.61e-0338442IPR002049
PathwayREACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

MMP25 PRSS3 CMA1

5.05e-0538273MM14611
Pubmed

Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.

FRY PKD1

4.98e-05847225907116
Pubmed

Analysis of the DNA sequence and duplication history of human chromosome 15.

GOLGA6L10 GOLGA6L19 GOLGA6L4

6.10e-055647316572171
Pubmed

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

MEGF6 MEGF8

6.40e-0594729693030
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

MEGF8 DYNC2H1 PKD1

3.41e-0410047325807483
Pubmed

Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation.

SOX17 UNC5B

4.06e-042247237823339
Pubmed

The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing.

SOX17 FZD4

6.14e-042747236197846
Pubmed

Genetic link between renal birth defects and congenital heart disease.

DYNC2H1 PKD1

6.61e-042847227002738
Pubmed

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.

FOXRED2 EDEM1 PIK3R2

1.11e-0315047332423001
Cytoband15q25.2

GOLGA6L10 GOLGA6L9 GOLGA6L4

1.13e-054346315q25.2
CytobandEnsembl 112 genes in cytogenetic band chr9q34

ODF2 C9orf163 TMEM210 PTRH1

3.18e-04325464chr9q34
CytobandEnsembl 112 genes in cytogenetic band chr15q25

GOLGA6L10 GOLGA6L9 GOLGA6L4

5.65e-04160463chr15q25
Cytoband9q34.11

ODF2 PTRH1

1.31e-03534629q34.11
Cytoband9q34.3

C9orf163 TMEM210

5.12e-031064629q34.3
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 MMP25 PRSS3 FRY UNC5B

6.22e-08198476e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 MMP25 PRSS3 UNC5B

2.07e-0619847572e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 MMP25 PRSS3 UNC5B

2.12e-061994759c40b3ee39860e9d8edafd007daec11abdd95435
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 MMP25 PRSS3 UNC5B

2.12e-0619947572b34bce8157abe389e95cd3ed8ba578dce0cbf6
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MMP25 CSF1 MEGF6 TMEM210

1.48e-051414742d2c468783730d81e3cacb0336027ba0ce1e5f4f
ToppCelldroplet-Pancreas-Exocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRSS3 EDEM1 KIF18B UMODL1

2.75e-05165474c17e00ec9dbe30fcded65a461231dbb13665ddac
ToppCellwk_20-22-Hematologic-Myeloid-Basophil|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

USP36 MMP25 FRY CSF1

4.12e-0518347493d821d5340caed0eef455d3d738be213ce5fff8
ToppCellfacs-GAT-Fat-24m-Endothelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX17 FRY ADIPOQ UNC5B

4.77e-05190474da2fcd4a2cc6e45c8174109d892f1424e39919a1
ToppCellfacs-GAT-Fat-24m-Endothelial-endothelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX17 FRY ADIPOQ UNC5B

4.77e-05190474e584eaccbc22aa7f7a4340ed8a2a8b45ddca93f4
ToppCellfacs-GAT-Fat-24m-Endothelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX17 FRY ADIPOQ UNC5B

4.77e-051904743395b2ff6ffadf84cdb1b5a37a5b6be05b56c30f
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX17 MEGF6 PCDH9 SPATA25

4.87e-05191474b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CSF1 MEGF8 PCDH9 PKD1

5.38e-05196474b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 MMP25 UNC5B

5.38e-05196474ed818de15f84f7f28bd06fd69d7876710da232a0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 PRSS3 UNC5B

5.49e-051974749244f087ba4b60fdc81d54ce91860de715b3e12c
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 PRSS3 FRY

5.49e-051974749e948b2e0f7e426f1e6f95bbbf4282fbddc2b99d
ToppCellmetastatic_Brain-Endothelial_cells-Tumor_ECs|metastatic_Brain / Location, Cell class and cell subclass

SOX17 FZD4 FRY UNC5B

5.60e-051984745e274f29cc796dae7d64d6035e904816c25f9914
ToppCellmetastatic_Brain-Endothelial_cells|metastatic_Brain / Location, Cell class and cell subclass

SOX17 FZD4 FRY UNC5B

5.60e-0519847497ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 PRSS3 FRY

5.71e-05199474236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 PRSS3 FRY

5.71e-05199474c5c12c8288fe868322bae9d691b91fee953ceb3e
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 MMP25 PRSS3

5.71e-05199474d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 PRSS3 FRY

5.71e-051994740602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 MMP25 PRSS3

5.71e-05199474cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 PRSS3 FRY

5.82e-0520047486ec951234015ced7126b016199e5869a0f22478
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 PRSS3 FRY

5.82e-05200474c239e6f5d23caa9a59b83e9b352b2d6a691dcb28
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX17 FZD4 PRSS3 FRY

5.82e-05200474061ba851f941c616ddb462512e826c412881c3ce
Diseaseamyloidosis (is_marker_for)

ADIPOQ CSF1

2.07e-055432DOID:9120 (is_marker_for)
Diseaseintracranial aneurysm (is_implicated_in)

SOX17 PKD1

1.36e-0412432DOID:10941 (is_implicated_in)
DiseasePolydactyly

MEGF8 DYNC2H1 PIK3R2

6.68e-04117433C0152427
Diseasehypertrophic cardiomyopathy (implicated_via_orthology)

XIRP1 PKD1

8.21e-0429432DOID:11984 (implicated_via_orthology)
Diseaselung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma

FRY DYNC2H1

2.63e-0352432EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Diseaseheart rate

ECHDC3 UMODL1 TNRC6A

4.31e-03225433EFO_0004326
Diseasecortical surface area measurement, neuroimaging measurement

DGKI MEGF6 TNRC6A

4.42e-03227433EFO_0004346, EFO_0010736
DiseaseAlveolitis, Fibrosing

ADIPOQ CMA1

6.55e-0383432C4721507
DiseasePulmonary Fibrosis

ADIPOQ CMA1

6.86e-0385432C0034069

Protein segments in the cluster

PeptideGeneStartEntry
PPGKRWMVAGLGNPG

PTRH1

26

Q86Y79
CPWSGGRYCMAPAPQ

UMODL1

146

Q5DID0
PDMADGSGWQPPRPC

C22orf39

36

Q6P5X5
MAGPGVPGAPAARWK

ATG16L2

1

Q8NAA4
LPKGACTGWMAGIPG

ADIPOQ

31

Q15848
MPGPLTCTPAWQGQG

C9orf163

1

Q8N9P6
MWPAGAGTKLPCPRD

NWD2

1

Q9ULI1
MGPNWLDCPAPSSGP

MMP25

501

Q9NPA2
AVMPPPMWGLLGCCF

GPR179

6

Q6PRD1
ALPAAWNPGMGSLQP

IHO1

301

Q8IYA8
GASGPMCLRRGPWAQ

ECHDC3

11

Q96DC8
LGHSDNCWMPPGLGP

PCDH9

1136

Q9HC56
PAACMLGPEGVPVSW

GLYATL1

206

Q969I3
PQGWAGPHCRMALCP

MEGF8

1436

Q7Z7M0
GAPVPQGAWMCGQAG

GOLGA6L4

516

A6NEF3
PVAGAPVPQGAWMCG

GOLGA6L9

371

A6NEM1
PVPGAPVPQGAWMCG

GOLGA6L10

461

A6NI86
PGAPVPQGAWMCGQA

GOLGA6L19

491

H0YKK7
MGLSAAAPLWGPPGL

FOXRED2

1

Q8IWF2
PGPNCTPAQGSRWPM

KIF18B

611

Q86Y91
MPAPAWDQGNRKGGP

PROX2

116

Q3B8N5
GGERCPQSVGWMPGL

PIK3R2

46

O00459
MAWRGAGPSVPGAPG

FZD4

1

Q9ULV1
LPCFMGWIPQDACGP

DYNC2H1

4246

Q8NCM8
MTAPGAAGRCPPTTW

CSF1

1

P09603
PRYCAGTMPWGNPGD

DGKI

611

O75912
PAACMLGPEGVPVSW

GLYATL1B

206

A0A0U1RQE8
APRRPGPGMCGPANW

EDEM1

86

Q92611
LPMPCTGGCWAPLVD

FRY

1611

Q5TBA9
LAPACMPGGRWCPGA

PKD1

636

P98161
MPGGRWCPGANICLP

PKD1

641

P98161
PWMPPGKSSARPVGC

ODF2

66

Q5BJF6
APGWMGPSCLQACPA

MEGF6

1021

O75095
PAVMAGLGPCPWAES

SOX17

21

Q9H6I2
WGPALAMPQARGCPG

SPATA25

61

Q9BR10
MLPAAARPLWGPCLG

MRPL12

1

P52815
CSWMGTGLCPGPLSP

ATAD3B

616

Q5T9A4
NFVPPGRMCRVAGWG

CMA1

136

P23946
MPAGWGSPGGLFLPC

C10orf55

101

Q5SWW7
MAPGPWPVSCLRGGP

TMEM210

1

A6NLX4
MAGWPGAGPLCVLGG

TMIE

1

Q8NEW7
REMWQDCLGPPVPGA

TMEM102

156

Q8N9M5
WRSRECMAPPPQNGG

UNC5B

321

Q8IZJ1
MCGPDDRCPARWPGP

PRSS3

1

P35030
PVLGPCWDPMALGTQ

ZGLP1

76

P0C6A0
PGGCTQMAWGPPGKA

XIRP1

1196

Q702N8
WCGDDMPLPGNRPTG

TNRC6A

1126

Q8NDV7
WCPGDRMGLSQAPPV

USP36

1001

Q9P275