Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tyrosine kinase activity	TYRO3 BTK SYK ROS1 TXK	7.46e-05	145	60	5	GO:0004713
GeneOntologyMolecularFunction	protein-arginine omega-N monomethyltransferase activity	PRMT8 PRMT1	8.83e-05	5	60	2	GO:0035241
GeneOntologyMolecularFunction	protein-arginine omega-N asymmetric methyltransferase activity	PRMT8 PRMT1	1.85e-04	7	60	2	GO:0035242
GeneOntologyMolecularFunction	trace-amine receptor activity	TAAR2 TAAR1	2.46e-04	8	60	2	GO:0001594
GeneOntologyMolecularFunction	non-membrane spanning protein tyrosine kinase activity	BTK SYK TXK	3.57e-04	46	60	3	GO:0004715
GeneOntologyMolecularFunction	arginine N-methyltransferase activity	PRMT8 PRMT1	5.75e-04	12	60	2	GO:0016273
GeneOntologyMolecularFunction	protein-arginine N-methyltransferase activity	PRMT8 PRMT1	5.75e-04	12	60	2	GO:0016274
GeneOntologyMolecularFunction	histone H4 methyltransferase activity	PRMT8 PRMT1	1.17e-03	17	60	2	GO:0140939
GeneOntologyMolecularFunction	histone methyltransferase activity	PRMT8 EED PRMT1	1.27e-03	71	60	3	GO:0042054
GeneOntologyMolecularFunction	GABA-gated chloride ion channel activity	GABRR1 GABRR2	1.32e-03	18	60	2	GO:0022851
GeneOntologyMolecularFunction	GABA-A receptor activity	GABRR1 GABRR2	1.47e-03	19	60	2	GO:0004890
GeneOntologyMolecularFunction	GABA receptor activity	GABRR1 GABRR2	1.97e-03	22	60	2	GO:0016917
GeneOntologyMolecularFunction	protein kinase activity	TYRO3 BMPR2 BTK SYK ROS1 CSNK2A3 TXK	2.08e-03	600	60	7	GO:0004672
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	TYRO3 BMPR2 ROS1	2.14e-03	85	60	3	GO:0019199
GeneOntologyMolecularFunction	S-adenosyl-L-methionine binding	PRMT8 PRMT1	2.16e-03	23	60	2	GO:1904047
GeneOntologyMolecularFunction	phospholipase activator activity	EED BTK	2.16e-03	23	60	2	GO:0016004
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H	MIOX NDUFB7 KMO	2.93e-03	95	60	3	GO:0016651
GeneOntologyMolecularFunction	lipase activator activity	EED BTK	2.97e-03	27	60	2	GO:0060229
GeneOntologyMolecularFunction	protein methyltransferase activity	PRMT8 EED PRMT1	3.69e-03	103	60	3	GO:0008276
GeneOntologyMolecularFunction	methyltransferase activity	PRMT8 PRDM11 EED PRMT1	3.85e-03	213	60	4	GO:0008168
GeneOntologyMolecularFunction	phospholipase binding	BTK SYK	4.16e-03	32	60	2	GO:0043274
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	PRMT8 PRDM11 EED PRMT1	4.60e-03	224	60	4	GO:0016741
GeneOntologyMolecularFunction	histone modifying activity	PRMT8 EED PRMT1 OGA	4.97e-03	229	60	4	GO:0140993
GeneOntologyMolecularFunction	monooxygenase activity	TYR MIOX KMO	5.02e-03	115	60	3	GO:0004497
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TYRO3 BMPR2 BTK SYK ROS1 CSNK2A3 TXK	5.21e-03	709	60	7	GO:0016773
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	TYRO3 GABRR1 GABRR2 IL12RB1 BMPR2 GPR153 TAAR2 OR2B3 ROS1 TAAR1	6.65e-03	1353	60	10	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	TAAR2 TAAR1	6.75e-03	41	60	2	GO:0008227
GeneOntologyCellularComponent	receptor complex	TYRO3 GABRR1 GABRR2 IL12RB1 TRBV28 TRBV27 BMPR2 TRBV12-4 TRBV6-5 TRBV6-4 SYK ROS1 LRP1B	1.85e-08	581	64	13	GO:0043235
GeneOntologyCellularComponent	T cell receptor complex	TRBV28 TRBV27 TRBV12-4 TRBV6-5 TRBV6-4 SYK	1.06e-05	163	64	6	GO:0042101
GeneOntologyCellularComponent	plasma membrane signaling receptor complex	IL12RB1 TRBV28 TRBV27 TRBV12-4 TRBV6-5 TRBV6-4 SYK	9.51e-05	350	64	7	GO:0098802
GeneOntologyCellularComponent	membrane protein complex	GABRR1 GABRR2 IL12RB1 TRBV28 TRBV27 TRBV12-4 SYNE2 TRBV6-5 TRBV6-4 VPS8 SYK CACNA1I NDUFB7	5.23e-04	1498	64	13	GO:0098796
MousePheno	polysyndactyly	TYRO3 LRP4 IFT122	1.29e-05	15	44	3	MP:0004083
Domain	TyrKc	TYRO3 BTK SYK ROS1 TXK	7.15e-06	88	57	5	SM00219
Domain	Tyr_kinase_cat_dom	TYRO3 BTK SYK ROS1 TXK	7.15e-06	88	57	5	IPR020635
Domain	GABAAa_rho_rcpt	GABRR1 GABRR2	9.15e-06	2	57	2	IPR008057
Domain	PROTEIN_KINASE_TYR	TYRO3 BTK SYK ROS1 TXK	1.15e-05	97	57	5	PS00109
Domain	Tyr_kinase_AS	TYRO3 BTK SYK ROS1 TXK	1.15e-05	97	57	5	IPR008266
Domain	LY	LRP4 ROS1 LRP1B	1.19e-05	15	57	3	SM00135
Domain	LDLR_classB_rpt	LRP4 ROS1 LRP1B	1.19e-05	15	57	3	IPR000033
Domain	Pkinase_Tyr	TYRO3 BTK SYK ROS1 TXK	4.57e-05	129	57	5	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	TYRO3 BTK SYK ROS1 TXK	6.30e-05	138	57	5	IPR001245
Domain	Protein_kinase_ATP_BS	TYRO3 BMPR2 BTK SYK ROS1 CSNK2A3 TXK	1.48e-04	379	57	7	IPR017441
Domain	TAAR_fam	TAAR2 TAAR1	1.90e-04	7	57	2	IPR009132
Domain	-	LRP4 ROS1 LRP1B	2.28e-04	39	57	3	2.120.10.30
Domain	SAM_MT_PRMT	PRMT8 PRMT1	3.25e-04	9	57	2	PS51678
Domain	Arg_MeTrfase	PRMT8 PRMT1	3.25e-04	9	57	2	IPR025799
Domain	6-blade_b-propeller_TolB-like	LRP4 ROS1 LRP1B	3.73e-04	46	57	3	IPR011042
Domain	PROTEIN_KINASE_ATP	TYRO3 BMPR2 BTK SYK ROS1 CSNK2A3 TXK	4.73e-04	459	57	7	PS00107
Domain	FAD-dep_OxRdtase	PIPOX KMO	5.92e-04	12	57	2	IPR006076
Domain	DAO	PIPOX KMO	5.92e-04	12	57	2	PF01266
Domain	Prot_kinase_dom	TYRO3 BMPR2 BTK SYK ROS1 CSNK2A3 TXK	6.89e-04	489	57	7	IPR000719
Domain	PROTEIN_KINASE_DOM	TYRO3 BMPR2 BTK SYK ROS1 CSNK2A3 TXK	7.23e-04	493	57	7	PS50011
Domain	Ldl_recept_b	LRP4 LRP1B	8.13e-04	14	57	2	PF00058
Domain	LDLRB	LRP4 LRP1B	8.13e-04	14	57	2	PS51120
Domain	Kinase-like_dom	TYRO3 BMPR2 BTK SYK ROS1 CSNK2A3 TXK	1.25e-03	542	57	7	IPR011009
Domain	GABAA/Glycine_rcpt	GABRR1 GABRR2	2.22e-03	23	57	2	IPR006028
Domain	EGF_CA	LRP4 EGFL8 LRP1B	2.31e-03	86	57	3	PF07645
Domain	cEGF	LRP4 LRP1B	2.84e-03	26	57	2	IPR026823
Domain	cEGF	LRP4 LRP1B	2.84e-03	26	57	2	PF12662
Domain	EGF_Ca-bd_CS	LRP4 EGFL8 LRP1B	3.24e-03	97	57	3	IPR018097
Domain	EGF_CA	LRP4 EGFL8 LRP1B	3.44e-03	99	57	3	PS01187
Domain	ARF	ARL8B ARL8A	3.52e-03	29	57	2	PS51417
Domain	Small_GTPase_ARF	ARL8B ARL8A	3.52e-03	29	57	2	IPR024156
Domain	ASX_HYDROXYL	LRP4 EGFL8 LRP1B	3.53e-03	100	57	3	PS00010
Domain	SH2	BTK SYK TXK	3.63e-03	101	57	3	PF00017
Domain	Arf	ARL8B ARL8A	4.02e-03	31	57	2	PF00025
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP4 EGFL8 LRP1B	4.16e-03	106	57	3	IPR000152
Domain	Small_GTPase_ARF/SAR	ARL8B ARL8A	4.55e-03	33	57	2	IPR006689
Domain	SH2	BTK SYK TXK	4.62e-03	110	57	3	SM00252
Domain	SH2	BTK SYK TXK	4.73e-03	111	57	3	PS50001
Domain	SH2	BTK SYK TXK	4.85e-03	112	57	3	IPR000980
Domain	-	BTK SYK TXK	4.85e-03	112	57	3	3.30.505.10
Domain	EGF_CA	LRP4 EGFL8 LRP1B	6.16e-03	122	57	3	SM00179
Domain	EGF-like_Ca-bd_dom	LRP4 EGFL8 LRP1B	6.44e-03	124	57	3	IPR001881
Domain	LDLR_class-A_CS	LRP4 LRP1B	6.63e-03	40	57	2	IPR023415
Domain	EGF	LRP4 EGFL8 LRP1B	6.73e-03	126	57	3	PF00008
Domain	Neurotransmitter_ion_chnl_CS	GABRR1 GABRR2	8.33e-03	45	57	2	IPR018000
Domain	Ldl_recept_a	LRP4 LRP1B	8.33e-03	45	57	2	PF00057
Domain	Neur_chan_memb	GABRR1 GABRR2	8.69e-03	46	57	2	PF02932
Domain	-	LRP4 LRP1B	8.69e-03	46	57	2	4.10.400.10
Domain	Neur_chan_LBD	GABRR1 GABRR2	9.06e-03	47	57	2	PF02931
Domain	NEUROTR_ION_CHANNEL	GABRR1 GABRR2	9.06e-03	47	57	2	PS00236
Domain	Neurotrans-gated_channel_TM	GABRR1 GABRR2	9.06e-03	47	57	2	IPR006029
Domain	-	GABRR1 GABRR2	9.06e-03	47	57	2	2.70.170.10
Domain	Neur_channel	GABRR1 GABRR2	9.06e-03	47	57	2	IPR006201
Domain	Neur_chan_lig-bd	GABRR1 GABRR2	9.06e-03	47	57	2	IPR006202
Pubmed	Physical localization of the mouse aryl hydrocarbon receptor nuclear translocator-2 (Arnt2) gene within the c112K deletion.	TYR FAH EED	2.37e-08	4	64	3	9722945
Pubmed	Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7.	TYR FAH EED	5.93e-08	5	64	3	7767008
Pubmed	N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations.	TYR FAH EED	3.31e-07	8	64	3	10224267
Pubmed	The protein tyrosine kinase family of the human genome.	TYRO3 BTK SYK ROS1 TXK	4.68e-07	83	64	5	11114734
Pubmed	The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.	TRBV28 TRBV27 TRBV12-4 TRBV6-5 TRBV6-4	9.18e-07	95	64	5	8650574
Pubmed	Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein.	ARL8B ARL8A	3.33e-06	2	64	2	14871887
Pubmed	The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.	GABRR1 GABRR2	3.33e-06	2	64	2	9153229
Pubmed	The albino-deletion complex of the mouse: molecular mapping of deletion breakpoints that define regions necessary for development of the embryonic and extraembryonic ectoderm.	TYR EED	3.33e-06	2	64	2	1684331
Pubmed	Elimination of the rho1 subunit abolishes GABA(C) receptor expression and alters visual processing in the mouse retina.	GABRR1 GABRR2	3.33e-06	2	64	2	12019334
Pubmed	Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.	GABRR1 GABRR2	3.33e-06	2	64	2	28660714
Pubmed	GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.	GABRR1 GABRR2	3.33e-06	2	64	2	19536785
Pubmed	Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2.	TAAR2 TAAR1	3.33e-06	2	64	2	23315425
Pubmed	Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma.	BTK SYK	3.33e-06	2	64	2	30872780
Pubmed	Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.	BTK SYK	3.33e-06	2	64	2	25170122
Pubmed	An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility.	ARL8B ARL8A	3.33e-06	2	64	2	16537643
Pubmed	Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.	ARL8B ARL8A	3.33e-06	2	64	2	30174114
Pubmed	Novel helical assembly in arginine methyltransferase 8.	PRMT8 PRMT1	3.33e-06	2	64	2	26876602
Pubmed	Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress.	TYR FAH	3.33e-06	2	64	2	12899938
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	TYR LRP4 LRP1B	7.72e-06	21	64	3	21337463
Pubmed	Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.	BTK SYK	9.99e-06	3	64	2	15509800
Pubmed	Splice variants of the mouse Tec gene are differentially expressed in vivo.	BTK TXK	9.99e-06	3	64	2	10343129
Pubmed	Cloning and characterization of mouse GABA(C) receptor subunits.	GABRR1 GABRR2	9.99e-06	3	64	2	9507960
Pubmed	Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS.	PRMT8 PRMT1	9.99e-06	3	64	2	23635657
Pubmed	Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.	GABRR1 GABRR2	9.99e-06	3	64	2	9839716
Pubmed	A mouse model of renal tubular injury of tyrosinemia type 1: development of de Toni Fanconi syndrome and apoptosis of renal tubular cells in Fah/Hpd double mutant mice.	TYR FAH	9.99e-06	3	64	2	10665936
Pubmed	Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis.	BTK SYK	9.99e-06	3	64	2	18566394
Pubmed	Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.	GABRR1 GABRR2	9.99e-06	3	64	2	10542332
Pubmed	BLNK mediates Syk-dependent Btk activation.	BTK SYK	9.99e-06	3	64	2	11226282
Pubmed	Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets.	BTK SYK	9.99e-06	3	64	2	37175486
Pubmed	Murine fumarylacetoacetate hydrolase (Fah) gene is disrupted by a neonatally lethal albino deletion that defines the hepatocyte-specific developmental regulation 1 (hsdr-1) locus.	TYR FAH	9.99e-06	3	64	2	1741389
Pubmed	Genomic mapping within the albino-deletion complex using individual early postimplantation mouse embryos.	TYR EED	9.99e-06	3	64	2	1617218
Pubmed	Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.	PRMT8 PRMT1	9.99e-06	3	64	2	23620769
Pubmed	Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice.	TYR FAH	9.99e-06	3	64	2	1644288
Pubmed	GABAC receptor sensitivity is modulated by interaction with MAP1B.	GABRR1 GABRR2	9.99e-06	3	64	2	11102469
Pubmed	Gene expression profiles of homogentisate-treated Fah-/- Hpd-/-mice using DNA microarrays.	TYR FAH	9.99e-06	3	64	2	16899383
Pubmed	A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.	BTK SYK	9.99e-06	3	64	2	16460447
Pubmed	GABAC receptors are functionally expressed in the intermediate zone and regulate radial migration in the embryonic mouse neocortex.	GABRR1 GABRR2	9.99e-06	3	64	2	20123002
Pubmed	Complete rescue of lethal albino c14CoS mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway.	TYR FAH	9.99e-06	3	64	2	9305902
Pubmed	Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.	PRMT8 SYNE2 PRMT1	1.03e-05	23	64	3	18320585
Pubmed	Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation.	ARL8B ARL8A	2.00e-05	4	64	2	15331635
Pubmed	Developmentally regulated expression of GABA receptor rho1 and rho2 subunits, L7 and cone-rod homeobox (CRX) genes in mouse retina.	GABRR1 GABRR2	2.00e-05	4	64	2	11520487
Pubmed	Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.	BTK SYK	2.00e-05	4	64	2	14656219
Pubmed	Tyro3 Modulates Mertk-Associated Retinal Degeneration.	TYR TYRO3	2.00e-05	4	64	2	26656104
Pubmed	Physical localization of eed: a region of mouse chromosome 7 required for gastrulation.	TYR EED	2.00e-05	4	64	2	7558026
Pubmed	Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.	BTK SYK	2.00e-05	4	64	2	25767114
Pubmed	Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.	GABRR1 GABRR2	2.00e-05	4	64	2	20820800
Pubmed	Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1.	TYR FAH	2.00e-05	4	64	2	11209059
Pubmed	Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.	LRP4 LRP1B	3.32e-05	5	64	2	20383322
Pubmed	ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.	GABRR1 GABRR2	3.32e-05	5	64	2	12431995
Pubmed	Identification of mutations from phenotype-driven ENU mutagenesis in mouse chromosome 7.	TYR FAH	3.32e-05	5	64	2	16180137
Pubmed	PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1.	GABRR1 GABRR2	3.32e-05	5	64	2	18325784
Pubmed	PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family.	PRMT8 PRMT1	3.32e-05	5	64	2	16051612
Pubmed	Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice.	TYR FAH	3.32e-05	5	64	2	9168903
Pubmed	The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro.	BTK SYK	3.32e-05	5	64	2	10427990
Pubmed	BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.	BTK SYK	3.32e-05	5	64	2	11163197
Pubmed	CD303 (BDCA-2) signals in plasmacytoid dendritic cells via a BCR-like signalosome involving Syk, Slp65 and PLCgamma2.	BTK SYK	3.32e-05	5	64	2	18022864
Pubmed	Genetic analysis of B cell antigen receptor signaling.	BTK SYK	4.98e-05	6	64	2	10358768
Pubmed	Regulation of Btk function by a major autophosphorylation site within the SH3 domain.	BTK SYK	4.98e-05	6	64	2	8630736
Pubmed	CoA Synthase is phosphorylated on tyrosines in mammalian cells, interacts with and is dephosphorylated by Shp2PTP.	BTK SYK	4.98e-05	6	64	2	19763791
Pubmed	Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.	BTK SYK	4.98e-05	6	64	2	10981967
Pubmed	Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo.	BTK SYK	4.98e-05	6	64	2	16788103
Pubmed	Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.	BTK SYK	4.98e-05	6	64	2	8629002
Pubmed	PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.	BTK SYK	6.96e-05	7	64	2	11598012
Pubmed	Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.	BTK SYK	6.96e-05	7	64	2	20167705
Pubmed	Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4.	GABRR1 GABRR2	6.96e-05	7	64	2	1315307
Pubmed	A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells.	GABRR1 GABRR2	6.96e-05	7	64	2	8940147
Pubmed	The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses.	TYR LRP4	6.96e-05	7	64	2	25368159
Pubmed	Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.	BTK SYK	6.96e-05	7	64	2	11606584
Pubmed	The distribution and characterization of endogenous protein arginine N-methyltransferase 8 in mouse CNS.	PRMT8 PRMT1	6.96e-05	7	64	2	19576965
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	EED SYNE2 FBRS IFT122 MSH4 IDE	9.26e-05	398	64	6	35016035
Pubmed	Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen.	PRMT8 PRMT1	9.27e-05	8	64	2	22179613
Pubmed	Mouse thioredoxin gene maps on chromosome 4, whereas its pseudogene maps on chromosome 1.	GABRR1 GABRR2	9.27e-05	8	64	2	8088797
Pubmed	Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.	TYR FAH	9.27e-05	8	64	2	11247670
Pubmed	Receptor association and tyrosine phosphorylation of S6 kinases.	BTK SYK	9.27e-05	8	64	2	16640565
Pubmed	Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.	PRMT8 PRMT1	1.19e-04	9	64	2	17925405
Pubmed	Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.	TAAR2 TAAR1	1.19e-04	9	64	2	15718104
Pubmed	Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size.	GABRR1 GABRR2	1.19e-04	9	64	2	15883645
Pubmed	A second class of chemosensory receptors in the olfactory epithelium.	TAAR2 TAAR1	1.19e-04	9	64	2	16878137
Pubmed	Phosphorylation of the recombinant rho1 GABA receptor.	GABRR1 GABRR2	1.19e-04	9	64	2	12175859
Pubmed	The DNA sequence and analysis of human chromosome 6.	GABRR1 GABRR2 TAAR2 OR2B3 ROS1 TAAR1 EGFL8	1.45e-04	622	64	7	14574404
Pubmed	Expression of trace amine-associated receptors in the Grueneberg ganglion.	TAAR2 TAAR1	1.49e-04	10	64	2	17556730
Pubmed	Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.	BTK SYK	1.49e-04	10	64	2	15814670
Pubmed	Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ.	BTK SYK	1.49e-04	10	64	2	21482705
Pubmed	Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing.	GABRR1 GABRR2	1.49e-04	10	64	2	30902970
Pubmed	Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder.	GABRR1 GABRR2	1.49e-04	10	64	2	20583128
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SYNE2 FBRS DNAH2 ARL8A IDE NEB IFIT1	1.70e-04	638	64	7	31182584
Pubmed	The genomic structure of human V beta 6 T cell antigen receptor genes.	TRBV28 TRBV6-4	1.81e-04	11	64	2	1660526
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP4 LRP1B	1.81e-04	11	64	2	24639464
Pubmed	Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.	BTK SYK	2.17e-04	12	64	2	10872802
Pubmed	M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.	SHOC1 MSH4	2.57e-04	13	64	2	36440627
Pubmed	BORC, a multisubunit complex that regulates lysosome positioning.	ARL8B ARL8A	2.57e-04	13	64	2	25898167
Pubmed	The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.	ARL8B ARL8A	2.57e-04	13	64	2	28325809
Pubmed	Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts.	GABRR1 GABRR2	2.99e-04	14	64	2	8649829
Pubmed	Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.	BTK SYK TXK	3.37e-04	73	64	3	24728074
Pubmed	A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias.	BTK SYK	3.93e-04	16	64	2	19464057
Pubmed	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.	BTK SYK TXK	3.94e-04	77	64	3	22973453
Pubmed	Wnt signaling and Dupuytren's disease.	SFRP4 MAFB	5.00e-04	18	64	2	21732829
Pubmed	Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.	GABRR1 GABRR2	5.00e-04	18	64	2	19078961
Pubmed	Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis.	SHOC1 MSH4	6.84e-04	21	64	2	30272023
Pubmed	A systematic survey of loss-of-function variants in human protein-coding genes.	GUCA1C KLK12	7.52e-04	22	64	2	22344438
Cytoband	7q34	TRBV28 TRBV27 TRBV12-4 TRBV6-5 TRBV6-4	3.84e-06	167	64	5	7q34
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRBV28 TRBV27 TRBV12-4 TRBV6-5 TRBV6-4	6.33e-06	185	64	5	chr7q34
Cytoband	6q15	GABRR1 GABRR2	8.67e-04	31	64	2	6q15
Cytoband	Ensembl 112 genes in cytogenetic band chr6q15	GABRR1 GABRR2	2.33e-03	51	64	2	chr6q15
GeneFamily	T cell receptor beta locus at 7q34	TRBV28 TRBV27 TRBV12-4 TRBV6-5 TRBV6-4	2.70e-06	87	46	5	372
GeneFamily	Protein arginine methyltransferases	PRMT8 PRMT1	2.25e-04	9	46	2	691
GeneFamily	Trace amine receptors	TAAR2 TAAR1	2.25e-04	9	46	2	188
GeneFamily	Low density lipoprotein receptors	LRP4 LRP1B	4.85e-04	13	46	2	634
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRR1 GABRR2	1.05e-03	19	46	2	563
GeneFamily	SH2 domain containing	BTK SYK TXK	2.16e-03	101	46	3	741
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	ARL8B ARL8A	2.81e-03	31	46	2	357
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	TYRO3 ROS1	4.64e-03	40	46	2	321
GeneFamily	Fibronectin type III domain containing	TYRO3 IL12RB1 ROS1	7.81e-03	160	46	3	555
Drug	Flunarizine dihydrochloride [30484-77-6]; Up 200; 8.4uM; HL60; HT_HG-U133A	GABRR2 FERMT1 PIPOX TAAR2 KLK12 KMO TXK	7.35e-07	196	59	7	2381_UP
Disease	N-acetylcarnosine measurement	GABRR1 GABRR2	1.13e-04	8	60	2	EFO_0022101
Disease	R-6-hydroxywarfarin measurement	DNAH2 MAFB LRP1B	1.64e-03	114	60	3	EFO_0803327
Disease	melanoma	TYR SYK ROS1 LRP1B	1.64e-03	248	60	4	C0025202
Disease	obsessive-compulsive symptom measurement	TAAR2 TAAR1	1.82e-03	31	60	2	EFO_0007802
Disease	Large cell carcinoma of lung	BTK ROS1	1.94e-03	32	60	2	C0345958

Protein segments in the cluster

Peptide	Gene	Start	Entry
ECVQDMDHENMFWYR	TRBV28	41	A0A5B6
WMEYLNMERIYHEFQ	EPG5	1446	Q9HCE0
CSTYRTMYRVMWREV	EGFL8	71	Q99944
IEMYEWYSKHMTRSQ	BTK	276	Q06187
MYLRCDHENQYAQWM	FERMT1	451	Q9BQL6
WMGYCLFYESMLNTV	PRMT8	186	Q9NR22
SEWMGYCLFYESMLN	PRMT1	161	Q99873
LYWKDCYEALMVNMH	NBEAL1	1711	Q6ZS30
MWERYCRGVNAIVYM	ARL8B	81	Q9NVJ2
MWERYCRGVSAIVYM	ARL8A	81	Q96BM9
HYVVIMNYWFCLRMA	OR2B3	131	O76000
YYYWMLSMQCLDIAQ	IFT122	916	Q9HBG6
MDVYYQRDMIIWSTQ	LRP1B	3926	Q9NZR2
HLEDLYWMASNYQQM	MAFB	81	Q9Y5Q3
WRTKQNLDYCFLMMY	MGAT4B	241	Q9UQ53
YTYICKYVDWIRMIM	KLK12	231	Q9UKR0
MYDLMNLCWTYDVEN	SYK	601	P43405
YHRMWMVCWPVNYRL	GPR153	106	Q6NV75
TQETHVWYRTFMMEY	GUCA1C	16	O95843
YDNHPFWFRCMYMLI	LPCAT3	261	Q6P1A2
FDYSQCDIWYMRFSM	EED	356	O75530
MEIRCHRYGWMTEDL	POGK	431	Q9P215
DWDYCEHRDYVMRMK	NDUFB7	86	P17568
MQAMYLQRYWVCFSL	FADS2B	321	A8MWK0
YQMYDYSLDMWRLGC	CSNK2A3	206	Q8NEV1
WCAMHVRVAYMILRH	FBRS	86	Q9HAH7
MDFTMTLYLRHYWKD	GABRR1	116	P24046
MYNYIEMRAHVNSSW	KMO	361	O15229
LEGWVEIMYYVMDAH	CACNA1I	356	Q9P0X4
MYALGLIYWEIFMRC	BMPR2	406	Q13873
MMWEYSHYLLFLQAI	DPY19L4	261	Q7Z388
MYWPARAQSMTYCIE	IL12RB1	356	P42701
FAWMYYHMGRLAEAQ	IFIT1	101	P09914
HAMYYLRLLMTEVAW	IDE	681	P14735
YMYWTMLQQLTHHSV	FAH	321	P16930
LCMWVRAMELYGRLY	DNAH2	3196	Q9P225
MDFTMTLYLRHYWKD	GABRR2	96	P28476
DRVLMSWGHDEYMYQ	MIOX	186	Q9UGB7
YDEVNMMTIRFWYCM	SYNE2	5286	Q8WXH0
YKHRMFWREMYSVEE	OGA	101	O60502
RVWYSEDYMKRLHSM	PRDM11	256	Q9NQV5
WLFSYCMEDIHMAFI	SLC46A3	316	Q7Z3Q1
NEYYMMWQLERCRSP	SHOC1	306	Q5VXU9
MRLMALSLQYRYCWI	SHOC1	941	Q5VXU9
QRICKMLYYLWMLHS	SCAMP2	146	O15127
CQESLREIYHMTYMI	MSH4	581	O15457
LMCWENRLYDAMIYV	VPS8	671	Q8N3P4
MLSYYRTMEWHEKHD	VPS50	336	Q96JG6
QYYDMRWSCEHLIMV	TMEM39A	311	Q9NV64
HQDVLIMCYEWRSRM	SFRP4	251	Q6FHJ7
YDLFKREHMMSCYWE	TBC1D8	821	O95759
FVWMHYYVSMDALLG	TYR	176	P14679
WLYQRMYFIMDELVC	ROS1	376	P08922
VMPYSMVRSAEHCWY	TAAR1	76	Q96RJ0
IMPYSMIRSVENCWY	TAAR2	96	Q9P1P5
TCSQNMNHEYMSWYR	TRBV27	41	A0A0K0K1C4
SGHDYLFWYRQTMMR	TRBV12-4	46	A0A0B4J2E0
APMSIYEVMYSCWHE	TXK	491	P42681
EDFYTRMMHECYQIW	PIPOX	61	Q9P0Z9
RCTQDMRHNAMYWYR	TRBV6-4	41	A0A1B0GX49
ECMEDVYDLMYQCWS	TYRO3	756	Q06418
RLYREVMWENYTNVM	ZNF214	26	Q9UL59
QCAQDMNHEYMSWYR	TRBV6-5	41	A0A0K0K1A5
AIVLYHEMGFMYWTD	LRP4	1171	O75096
VSDMDYRNYLHQWTC	NEB	4076	P20929