Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 KCNJ5 ATP12A PKD1L3 OPRM1	3.85e-07	465	67	11	GO:0046873
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 OPRM1	7.65e-07	152	67	7	GO:0022843
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 ATP12A PKD1L3 OPRM1	1.02e-06	627	67	12	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 ATP12A PKD1L3 OPRM1	1.86e-06	664	67	12	GO:0008324
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	KCNH6 KCNH7 KCNH2 KCNJ5	2.23e-06	28	67	4	GO:0005242
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 OPRM1	2.55e-06	182	67	7	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 OPRM1	2.75e-06	184	67	7	GO:0022832
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 ATP12A PKD1L3 OPRM1	7.23e-06	758	67	12	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 ATP12A PKD1L3 OPRM1	1.14e-05	793	67	12	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 PKD1L3 OPRM1	1.89e-05	343	67	8	GO:0005261
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKD3 PRKD2 PRKD1	1.96e-05	16	67	3	GO:0004697
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	KCNH6 KCNH7 SLC9A5 KCNH2 KCNJ5 ATP12A	2.05e-05	167	67	6	GO:0015079
GeneOntologyMolecularFunction	transporter activity	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 SLC35E1 RFT1 ATP12A PKD1L3 OPRM1	7.87e-05	1289	67	14	GO:0005215
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	KCNH6 KCNH7 CATSPER2 KCNH2 KCNJ5	1.07e-04	140	67	5	GO:0099094
GeneOntologyMolecularFunction	gated channel activity	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 OPRM1	1.27e-04	334	67	7	GO:0022836
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 SLC35E1 ATP12A PKD1L3 OPRM1	1.28e-04	1180	67	13	GO:0022857
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 PKD1L3 OPRM1	1.46e-04	459	67	8	GO:0005216
GeneOntologyMolecularFunction	channel activity	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 PKD1L3 OPRM1	3.62e-04	525	67	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 PKD1L3 OPRM1	3.66e-04	526	67	8	GO:0022803
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCNH6 KCNH7 KCNH2 KCNJ5	3.84e-04	102	67	4	GO:0005249
GeneOntologyMolecularFunction	glycosyltransferase activity	ST6GAL2 GLT6D1 PIGP UGCG UGGT2 GALNT16	4.08e-04	288	67	6	GO:0016757
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	KCNH6 KCNH7 CATSPER2 KCNH2 KCNJ5	4.76e-04	193	67	5	GO:0015276
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1S CATSPER2 OPRM1	4.94e-04	46	67	3	GO:0005245
GeneOntologyMolecularFunction	ligand-gated channel activity	KCNH6 KCNH7 CATSPER2 KCNH2 KCNJ5	5.23e-04	197	67	5	GO:0022834
GeneOntologyMolecularFunction	hexosyltransferase activity	GLT6D1 PIGP UGCG UGGT2 GALNT16	7.13e-04	211	67	5	GO:0016758
GeneOntologyMolecularFunction	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	KCNH2 KCNJ5	7.16e-04	12	67	2	GO:1902282
GeneOntologyMolecularFunction	UDP-glucosyltransferase activity	UGCG UGGT2	8.45e-04	13	67	2	GO:0035251
GeneOntologyMolecularFunction	vinculin binding	DMD UTRN	8.45e-04	13	67	2	GO:0017166
GeneOntologyMolecularFunction	potassium channel activity	KCNH6 KCNH7 KCNH2 KCNJ5	9.04e-04	128	67	4	GO:0005267
GeneOntologyMolecularFunction	calcium channel activity	CACNA1S CATSPER2 PKD1L3 OPRM1	9.30e-04	129	67	4	GO:0005262
GeneOntologyMolecularFunction	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	KCNH2 KCNJ5	1.13e-03	15	67	2	GO:0086008
GeneOntologyMolecularFunction	prenyltransferase activity	FNTB DHDDS	1.64e-03	18	67	2	GO:0004659
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1S CATSPER2 PKD1L3 OPRM1	1.66e-03	151	67	4	GO:0015085
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	PIGP UGCG UGGT2 GALNT16	1.75e-03	153	67	4	GO:0008194
GeneOntologyMolecularFunction	ubiquitin-specific protease binding	SART3 MARCHF6	2.03e-03	20	67	2	GO:1990381
GeneOntologyMolecularFunction	glucosyltransferase activity	UGCG UGGT2	2.45e-03	22	67	2	GO:0046527
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	USP11 CTSK SENP7	3.03e-03	86	67	3	GO:0004197
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 PRKD1 DMD ATP12A PKD1L3 UTRN OPRM1	1.99e-07	922	67	15	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 PRKD1 DMD ATP12A PKD1L3 UTRN OPRM1	2.62e-07	942	67	15	GO:0098655
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 PRKD1 DMD ATP12A PKD1L3 UTRN OPRM1	6.93e-07	1017	67	15	GO:0098660
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 PRKD1 DMD ATP12A PKD1L3 UTRN OPRM1	2.18e-06	1115	67	15	GO:0034220
GeneOntologyBiologicalProcess	metal ion transport	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 KCNJ5 PRKD1 DMD ATP12A PKD1L3 UTRN OPRM1	3.20e-06	1000	67	14	GO:0030001
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 PRKD1 DMD ATP12A PKD1L3 UTRN OPRM1	3.44e-06	1157	67	15	GO:0006812
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	PRKD3 PRKD2 PIGP UGCG PRKD1 PIGU	1.20e-05	157	67	6	GO:0046467
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC6A18 KCNH6 CACNA1S KCNH7 SLC9A5 CATSPER2 KCNH2 SLC15A4 KCNJ5 PRKD1 DMD ATP12A PKD1L3 UTRN OPRM1	2.69e-05	1374	67	15	GO:0006811
GeneOntologyBiologicalProcess	membrane repolarization during cardiac muscle cell action potential	KCNH6 KCNH2 KCNJ5	9.06e-05	27	67	3	GO:0086013
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1S SLC9A5 KCNH2 KCNJ5 ATP12A	9.88e-05	142	67	5	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1S SLC9A5 KCNH2 KCNJ5 ATP12A	9.88e-05	142	67	5	GO:0098659
GeneOntologyBiologicalProcess	membrane lipid metabolic process	PRKD3 PRKD2 PIGP UGCG PRKD1 PIGU	9.95e-05	229	67	6	GO:0006643
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1S SLC9A5 KCNH2 SLC15A4 KCNJ5 ATP12A	1.02e-04	230	67	6	GO:0098739
GeneOntologyBiologicalProcess	potassium ion transmembrane transport	KCNH6 KCNH7 SLC9A5 KCNH2 KCNJ5 ATP12A	1.07e-04	232	67	6	GO:0071805
GeneOntologyBiologicalProcess	ventricular cardiac muscle cell membrane repolarization	KCNH6 KCNH2 KCNJ5	1.25e-04	30	67	3	GO:0099625
GeneOntologyBiologicalProcess	membrane repolarization during action potential	KCNH6 KCNH2 KCNJ5	1.38e-04	31	67	3	GO:0086011
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	KCNH6 KCNH2 KCNJ5 DMD	1.85e-04	87	67	4	GO:0086001
GeneOntologyBiologicalProcess	glycosylation	ST6GAL2 GLT6D1 DHDDS UGGT2 RFT1 GALNT16	2.43e-04	270	67	6	GO:0070085
GeneOntologyBiologicalProcess	potassium ion transport	KCNH6 KCNH7 SLC9A5 KCNH2 KCNJ5 ATP12A	2.53e-04	272	67	6	GO:0006813
GeneOntologyBiologicalProcess	regulation of skeletal muscle contraction by calcium ion signaling	PRKD1 DMD	2.87e-04	8	67	2	GO:0014722
GeneOntologyBiologicalProcess	cardiac muscle cell membrane repolarization	KCNH6 KCNH2 KCNJ5	3.20e-04	41	67	3	GO:0099622
GeneOntologyBiologicalProcess	regulation of heart rate by cardiac conduction	KCNH6 KCNH2 KCNJ5	3.20e-04	41	67	3	GO:0086091
GeneOntologyBiologicalProcess	carbohydrate derivative metabolic process	ST6GAL2 MDP1 PDE4C PIGP JMJD8 UGCG DHDDS UGGT2 RFT1 PIGU GALNT16 DGAT1	5.28e-04	1226	67	12	GO:1901135
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	PRKD3 PRKD2 UGCG PRKD1	5.72e-04	117	67	4	GO:0030148
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC6A18 SLC9A5 DMD ATP12A UTRN	5.78e-04	208	67	5	GO:0035725
GeneOntologyBiologicalProcess	regulation of system process	KCNH6 CACNA1S UTS2R KCNH2 KCNJ5 PRKD1 DMD DGAT1 OPRM1	5.88e-04	734	67	9	GO:0044057
GeneOntologyBiologicalProcess	potassium ion import across plasma membrane	KCNH2 KCNJ5 ATP12A	6.10e-04	51	67	3	GO:1990573
GeneOntologyBiologicalProcess	striated muscle contraction	CACNA1S KCNH2 KCNJ5 PRKD1 DMD	7.00e-04	217	67	5	GO:0006941
GeneOntologyBiologicalProcess	membrane repolarization	KCNH6 KCNH2 KCNJ5	8.03e-04	56	67	3	GO:0086009
GeneOntologyBiologicalProcess	regulation of heart rate	KCNH6 KCNH2 KCNJ5 DMD	8.25e-04	129	67	4	GO:0002027
GeneOntologyCellularComponent	membrane protein complex	SNF8 KCNH6 CACNA1S KCNH7 SYNE3 PIGP CATSPER2 KCNH2 KCNJ5 MARCHF6 DMD ATP12A PKD1L3 PIGU UTRN	5.19e-05	1498	66	15	GO:0098796
GeneOntologyCellularComponent	inward rectifier potassium channel complex	KCNH2 KCNJ5	5.87e-05	4	66	2	GO:1902937
GeneOntologyCellularComponent	monoatomic ion channel complex	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 PKD1L3	1.86e-04	378	66	7	GO:0034702
GeneOntologyCellularComponent	transmembrane transporter complex	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 ATP12A PKD1L3	2.34e-04	523	66	8	GO:1902495
GeneOntologyCellularComponent	transporter complex	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2 KCNJ5 ATP12A PKD1L3	3.28e-04	550	66	8	GO:1990351
GeneOntologyCellularComponent	sarcolemma	CACNA1S KCNJ5 DMD UTRN OPRM1	3.36e-04	190	66	5	GO:0042383
GeneOntologyCellularComponent	polyprenyl diphosphate synthase complex	FNTB DHDDS	6.35e-04	12	66	2	GO:0032476
GeneOntologyCellularComponent	cation channel complex	CACNA1S CATSPER2 KCNH2 KCNJ5 PKD1L3	8.80e-04	235	66	5	GO:0034703
GeneOntologyCellularComponent	dystrophin-associated glycoprotein complex	DMD UTRN	1.80e-03	20	66	2	GO:0016010
GeneOntologyCellularComponent	filopodium membrane	DMD UTRN	1.98e-03	21	66	2	GO:0031527
GeneOntologyCellularComponent	T-tubule	CACNA1S KCNJ5 OPRM1	2.00e-03	79	66	3	GO:0030315
Domain	Protein_Kinase_C_mu-related	PRKD3 PRKD2 PRKD1	4.21e-08	3	66	3	IPR015727
Domain	K_chnl_volt-dep_ERG	KCNH6 KCNH7 KCNH2	4.21e-08	3	66	3	IPR003967
Domain	PAS_9	KCNH6 KCNH7 KCNH2	4.97e-06	10	66	3	PF13426
Domain	Dystrophin	DMD UTRN	1.23e-05	2	66	2	IPR016344
Domain	K_chnl_volt-dep_EAG/ELK/ERG	KCNH6 KCNH7 KCNH2	1.49e-05	14	66	3	IPR003938
Domain	Ion_trans_dom	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2	5.15e-05	114	66	5	IPR005821
Domain	Ion_trans	KCNH6 CACNA1S KCNH7 CATSPER2 KCNH2	5.15e-05	114	66	5	PF00520
Domain	DAG/PE-bd	PRKD3 PRKD2 PRKD1	5.36e-05	21	66	3	IPR020454
Domain	Spectrin	SYNE3 DMD UTRN	7.10e-05	23	66	3	PF00435
Domain	PAS-assoc_C	KCNH6 KCNH7 KCNH2	8.09e-05	24	66	3	IPR000700
Domain	PAC	KCNH6 KCNH7 KCNH2	1.03e-04	26	66	3	IPR001610
Domain	PAC	KCNH6 KCNH7 KCNH2	1.03e-04	26	66	3	SM00086
Domain	PAC	KCNH6 KCNH7 KCNH2	1.03e-04	26	66	3	PS50113
Domain	Spectrin_repeat	SYNE3 DMD UTRN	1.44e-04	29	66	3	IPR002017
Domain	EF-hand_dom_typ1	DMD UTRN	1.83e-04	6	66	2	IPR015153
Domain	EF-hand_dom_typ2	DMD UTRN	1.83e-04	6	66	2	IPR015154
Domain	EF-hand_2	DMD UTRN	1.83e-04	6	66	2	PF09068
Domain	EF-hand_3	DMD UTRN	1.83e-04	6	66	2	PF09069
Domain	-	GLT6D1 UGCG UGGT2 GALNT16	1.93e-04	81	66	4	3.90.550.10
Domain	CNMP_BINDING_1	KCNH6 KCNH7 KCNH2	1.94e-04	32	66	3	PS00888
Domain	CNMP_BINDING_2	KCNH6 KCNH7 KCNH2	1.94e-04	32	66	3	PS00889
Domain	Spectrin/alpha-actinin	SYNE3 DMD UTRN	1.94e-04	32	66	3	IPR018159
Domain	SPEC	SYNE3 DMD UTRN	1.94e-04	32	66	3	SM00150
Domain	cNMP	KCNH6 KCNH7 KCNH2	2.33e-04	34	66	3	SM00100
Domain	PAS	KCNH6 KCNH7 KCNH2	2.33e-04	34	66	3	IPR000014
Domain	PAS	KCNH6 KCNH7 KCNH2	2.33e-04	34	66	3	PS50112
Domain	cNMP_binding	KCNH6 KCNH7 KCNH2	2.33e-04	34	66	3	PF00027
Domain	cNMP-bd_dom	KCNH6 KCNH7 KCNH2	2.54e-04	35	66	3	IPR000595
Domain	CNMP_BINDING_3	KCNH6 KCNH7 KCNH2	2.54e-04	35	66	3	PS50042
Domain	Nucleotide-diphossugar_trans	GLT6D1 UGCG UGGT2 GALNT16	2.65e-04	88	66	4	IPR029044
Domain	cNMP-bd-like	KCNH6 KCNH7 KCNH2	3.25e-04	38	66	3	IPR018490
Domain	-	KCNH6 KCNH7 KCNH2	6.51e-04	48	66	3	2.60.120.10
Domain	RmlC-like_jellyroll	KCNH6 KCNH7 KCNH2	7.78e-04	51	66	3	IPR014710
Domain	C1_1	PRKD3 PRKD2 PRKD1	1.08e-03	57	66	3	PF00130
Domain	ZF_DAG_PE_1	PRKD3 PRKD2 PRKD1	1.51e-03	64	66	3	PS00479
Domain	ZF_DAG_PE_2	PRKD3 PRKD2 PRKD1	1.51e-03	64	66	3	PS50081
Domain	C1	PRKD3 PRKD2 PRKD1	1.57e-03	65	66	3	SM00109
Domain	PE/DAG-bd	PRKD3 PRKD2 PRKD1	1.65e-03	66	66	3	IPR002219
Domain	ZZ	DMD UTRN	1.81e-03	18	66	2	PF00569
Domain	ZF_ZZ_2	DMD UTRN	1.81e-03	18	66	2	PS50135
Domain	ZF_ZZ_1	DMD UTRN	1.81e-03	18	66	2	PS01357
Domain	Znf_ZZ	DMD UTRN	2.02e-03	19	66	2	IPR000433
Domain	ZnF_ZZ	DMD UTRN	2.02e-03	19	66	2	SM00291
Domain	Actinin_actin-bd_CS	DMD UTRN	2.97e-03	23	66	2	IPR001589
Domain	ACTININ_2	DMD UTRN	2.97e-03	23	66	2	PS00020
Domain	ACTININ_1	DMD UTRN	2.97e-03	23	66	2	PS00019
Domain	PAS	KCNH6 KCNH2	3.50e-03	25	66	2	PF00989
Domain	PAS_fold	KCNH6 KCNH2	3.50e-03	25	66	2	IPR013767
Domain	Glycos_transf_2	UGCG GALNT16	5.02e-03	30	66	2	PF00535
Domain	Glyco_trans_2-like	UGCG GALNT16	5.02e-03	30	66	2	IPR001173
Domain	PAS	KCNH7 KCNH2	5.70e-03	32	66	2	SM00091
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_NFKB_SIGNALING_PATHWAY	PRKD3 PRKD2 PRKD1	1.85e-05	15	50	3	M47816
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	PRKD3 PRKD2 PRKD1	3.00e-04	37	50	3	M554
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNH6 KCNH7 KCNH2 KCNJ5	3.96e-04	98	50	4	MM14545
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCNH6 KCNH7 KCNH2	4.07e-04	41	50	3	MM14546
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCNH6 KCNH7 KCNH2	4.69e-04	43	50	3	M1056
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNH6 KCNH7 KCNH2 KCNJ5	4.78e-04	103	50	4	M1073
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	PRKD3 PRKD2 UGCG PRKD1	5.52e-04	107	50	4	M14857
Pubmed	Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.	PRKD3 PRKD2 PRKD1	7.15e-09	3	68	3	26253275
Pubmed	Expression of the protein kinase D (PKD) family during mouse embryogenesis.	PRKD3 PRKD2 PRKD1	7.15e-09	3	68	3	16377259
Pubmed	Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3.	KCNH6 KCNH7 KCNH2	7.15e-09	3	68	3	14643686
Pubmed	A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.	PRKD3 PRKD2 PRKD1	7.15e-09	3	68	3	27662904
Pubmed	Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.	PRKD3 PRKD2 PRKD1	7.15e-09	3	68	3	32747433
Pubmed	Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.	PRKD3 PRKD2 PRKD1	7.15e-09	3	68	3	26426580
Pubmed	Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.	KCNH6 KCNH7 KCNH2	7.15e-09	3	68	3	35818223
Pubmed	HERG K(+) currents in human prolactin-secreting adenoma cells.	KCNH6 KCNH7 KCNH2	7.15e-09	3	68	3	12634931
Pubmed	Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart.	PRKD3 PRKD2 PRKD1	7.15e-09	3	68	3	38419169
Pubmed	Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.	PRKD3 PRKD2 PRKD1	2.86e-08	4	68	3	14743217
Pubmed	Protein kinase D regulates RhoA activity via rhotekin phosphorylation.	PRKD3 PRKD2 PRKD1	7.13e-08	5	68	3	22228765
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	SYNE3 DENND4B RETREG1 NUP98 TMEM209 SLC35E1 UGGT2 RFT1 PIGU	3.27e-07	468	68	9	31056421
Pubmed	Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.	KCNH6 KCNH7 KCNH2	8.49e-07	10	68	3	26503718
Pubmed	Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	10525423
Pubmed	Distribution of dystrophin- and utrophin-associated protein complexes during activation of human neutrophils.	DMD UTRN	3.77e-06	2	68	2	20434517
Pubmed	Plasma lipidomic analysis shows a disease progression signature in mdx mice.	DMD UTRN	3.77e-06	2	68	2	34155298
Pubmed	In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.	DMD UTRN	3.77e-06	2	68	2	28790199
Pubmed	Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice.	DMD UTRN	3.77e-06	2	68	2	24466085
Pubmed	Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.	PRKD3 PRKD2	3.77e-06	2	68	2	24840177
Pubmed	The Angiotensin Converting Enzyme Inhibitor Lisinopril Improves Muscle Histopathology but not Contractile Function in a Mouse Model of Duchenne Muscular Dystrophy.	DMD UTRN	3.77e-06	2	68	2	27110493
Pubmed	Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice.	DMD UTRN	3.77e-06	2	68	2	24781208
Pubmed	Isolation and characterization of a genomic clone from the murine utrophin locus.	DMD UTRN	3.77e-06	2	68	2	8268660
Pubmed	Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	25859846
Pubmed	G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain.	DMD UTRN	3.77e-06	2	68	2	7731967
Pubmed	Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models.	DMD UTRN	3.77e-06	2	68	2	27037492
Pubmed	Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue.	DMD UTRN	3.77e-06	2	68	2	16710609
Pubmed	Improvement in survival and muscle function in an mdx/utrn(-/-) double mutant mouse using a human retinal dystrophin transgene.	DMD UTRN	3.77e-06	2	68	2	16487708
Pubmed	Nonclinical Exon Skipping Studies with 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn-/- Mice Inspired by Clinical Trial Results.	DMD UTRN	3.77e-06	2	68	2	30672725
Pubmed	Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.	DMD UTRN	3.77e-06	2	68	2	21677768
Pubmed	Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.	PRKD3 PRKD2	3.77e-06	2	68	2	30841931
Pubmed	Talin, vinculin and DRP (utrophin) concentrations are increased at mdx myotendinous junctions following onset of necrosis.	DMD UTRN	3.77e-06	2	68	2	7962191
Pubmed	Consequences of the combined deficiency in dystrophin and utrophin on the mechanical properties and myosin composition of some limb and respiratory muscles of the mouse.	DMD UTRN	3.77e-06	2	68	2	9713852
Pubmed	Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	25607927
Pubmed	Does utrophin expression in muscles of mdx mice during postnatal development functionally compensate for dystrophin deficiency?	DMD UTRN	3.77e-06	2	68	2	8021701
Pubmed	Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.	DMD UTRN	3.77e-06	2	68	2	26974331
Pubmed	Developmental studies of dystrophin-positive fibers in mdx, and DRP localization.	DMD UTRN	3.77e-06	2	68	2	8433092
Pubmed	Second-generation compound for the modulation of utrophin in the therapy of DMD.	DMD UTRN	3.77e-06	2	68	2	25935002
Pubmed	Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice.	DMD UTRN	3.77e-06	2	68	2	16024571
Pubmed	Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	28453658
Pubmed	A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin.	DMD UTRN	3.77e-06	2	68	2	11801396
Pubmed	Apo-dystrophin-1 and apo-dystrophin-2, products of the Duchenne muscular dystrophy locus: expression during mouse embryogenesis and in cultured cell lines.	DMD UTRN	3.77e-06	2	68	2	7987307
Pubmed	Utility of dystrophin and utrophin staining in childhood muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	16295426
Pubmed	Comparative analysis of the human dystrophin and utrophin gene structures.	DMD UTRN	3.77e-06	2	68	2	11861579
Pubmed	Distinct mechanical properties in homologous spectrin-like repeats of utrophin.	DMD UTRN	3.77e-06	2	68	2	30914715
Pubmed	Dystrophin is a microtubule-associated protein.	DMD UTRN	3.77e-06	2	68	2	19651889
Pubmed	Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice.	DMD UTRN	3.77e-06	2	68	2	9590295
Pubmed	Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains.	DMD UTRN	3.77e-06	2	68	2	22284942
Pubmed	Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.	DMD UTRN	3.77e-06	2	68	2	29879154
Pubmed	Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.	DMD UTRN	3.77e-06	2	68	2	17889902
Pubmed	Identification of Dp71 isoforms in the platelet membrane cytoskeleton. Potential role in thrombin-mediated platelet adhesion.	DMD UTRN	3.77e-06	2	68	2	12370193
Pubmed	Ether-à-go-go-related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neurons.	KCNH7 KCNH2	3.77e-06	2	68	2	19359372
Pubmed	Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.	PRKD2 PRKD1	3.77e-06	2	68	2	18753385
Pubmed	Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models.	DMD UTRN	3.77e-06	2	68	2	32025735
Pubmed	Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice.	DMD UTRN	3.77e-06	2	68	2	27836895
Pubmed	BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle.	DMD UTRN	3.77e-06	2	68	2	27750047
Pubmed	Prevention of dystrophin-deficient cardiomyopathy in twenty-one-month-old carrier mice by mosaic dystrophin expression or complementary dystrophin/utrophin expression.	DMD UTRN	3.77e-06	2	68	2	17967782
Pubmed	Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.	DMD UTRN	3.77e-06	2	68	2	21062902
Pubmed	Matricellular Protein CCN5 Gene Transfer Ameliorates Cardiac and Skeletal Dysfunction in mdx/utrn (±) Haploinsufficient Mice by Reducing Fibrosis and Upregulating Utrophin Expression.	DMD UTRN	3.77e-06	2	68	2	35557546
Pubmed	Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice.	DMD UTRN	3.77e-06	2	68	2	37626761
Pubmed	Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin.	DMD UTRN	3.77e-06	2	68	2	15565469
Pubmed	Functional redundancy of protein kinase D1 and protein kinase D2 in neuronal polarity.	PRKD2 PRKD1	3.77e-06	2	68	2	25639845
Pubmed	The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains.	DMD UTRN	3.77e-06	2	68	2	26516677
Pubmed	Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging.	DMD UTRN	3.77e-06	2	68	2	22209498
Pubmed	A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET.	DMD UTRN	3.77e-06	2	68	2	37108685
Pubmed	Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene.	DMD UTRN	3.77e-06	2	68	2	10694796
Pubmed	Dystrophin and dystrophin-related protein in the central nervous system of normal controls and Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	8171962
Pubmed	Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice.	DMD UTRN	3.77e-06	2	68	2	27822449
Pubmed	Micro-dystrophin gene therapy prevents heart failure in an improved Duchenne muscular dystrophy cardiomyopathy mouse model.	DMD UTRN	3.77e-06	2	68	2	33651713
Pubmed	The eag family of K+ channels in Drosophila and mammals.	KCNH6 KCNH7	3.77e-06	2	68	2	10414305
Pubmed	Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.	DMD UTRN	3.77e-06	2	68	2	22275054
Pubmed	NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.	DMD UTRN	3.77e-06	2	68	2	27798264
Pubmed	The role of PKD in cell polarity, biosynthetic pathways, and organelle/F-actin distribution.	PRKD2 PRKD1	3.77e-06	2	68	2	24492625
Pubmed	Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice.	DMD UTRN	3.77e-06	2	68	2	31506484
Pubmed	Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells.	PRKD2 PRKD1	3.77e-06	2	68	2	20819079
Pubmed	Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	9288752
Pubmed	Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	9288751
Pubmed	Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system.	PRKD2 PRKD1	3.77e-06	2	68	2	22217708
Pubmed	Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.	DMD UTRN	3.77e-06	2	68	2	24337461
Pubmed	Combined gene therapy via VEGF and mini-dystrophin synergistically improves pathologies in temporalis muscle of dystrophin/utrophin double knockout mice.	DMD UTRN	3.77e-06	2	68	2	33987645
Pubmed	Activation of calcineurin and stress activated protein kinase/p38-mitogen activated protein kinase in hearts of utrophin-dystrophin knockout mice.	DMD UTRN	3.77e-06	2	68	2	11297940
Pubmed	Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice.	DMD UTRN	3.77e-06	2	68	2	29408646
Pubmed	Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.	PRKD3 PRKD2	3.77e-06	2	68	2	25802335
Pubmed	PKD Phosphorylation as Novel Pathway of KV11.1 Regulation.	KCNH2 PRKD1	3.77e-06	2	68	2	29949809
Pubmed	Genomic analysis of recurrences and high-grade forms of polymorphous adenocarcinoma.	PRKD2 PRKD1	3.77e-06	2	68	2	30843621
Pubmed	Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping.	DMD UTRN	3.77e-06	2	68	2	22388933
Pubmed	Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.	DMD UTRN	3.77e-06	2	68	2	25642938
Pubmed	Activation of non-myogenic mesenchymal stem cells during the disease progression in dystrophic dystrophin/utrophin knockout mice.	DMD UTRN	3.77e-06	2	68	2	25859011
Pubmed	Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice.	DMD UTRN	3.77e-06	2	68	2	15703201
Pubmed	Microtubule binding distinguishes dystrophin from utrophin.	DMD UTRN	3.77e-06	2	68	2	24706788
Pubmed	Utrophin suppresses low frequency oscillations and coupled gating of mechanosensitive ion channels in dystrophic skeletal muscle.	DMD UTRN	3.77e-06	2	68	2	25941878
Pubmed	Duchenne muscular dystrophy and the neuromuscular junction: the utrophin link.	DMD UTRN	3.77e-06	2	68	2	9297964
Pubmed	Dystrophin and utrophin do not play crucial roles in nonmuscle tissues in mice.	DMD UTRN	3.77e-06	2	68	2	10204788
Pubmed	Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.	PRKD3 PRKD2	3.77e-06	2	68	2	23393329
Pubmed	SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.	DMD UTRN	3.77e-06	2	68	2	25652448
Pubmed	Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis.	DMD UTRN	3.77e-06	2	68	2	28785010
Pubmed	The role of proteases in excitation-contraction coupling failure in muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	25298424
Pubmed	Restoration of all dystrophin protein interactions by functional domains in trans does not rescue dystrophy.	DMD UTRN	3.77e-06	2	68	2	16307000
Pubmed	Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice.	DMD UTRN	3.77e-06	2	68	2	21949353
Pubmed	Dystrophin and utrophin "double knockout" dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities.	DMD UTRN	3.77e-06	2	68	2	23097179
Pubmed	rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.	DMD UTRN	3.77e-06	2	68	2	16819550
Cytoband	Ensembl 112 genes in cytogenetic band chr5p15	SLC6A18 MARCHF6 RETREG1 NSUN2	2.47e-04	204	68	4	chr5p15
GeneFamily	Potassium voltage-gated channels	KCNH6 KCNH7 KCNH2	1.72e-04	40	49	3	274
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	DMD UTRN	1.07e-03	18	49	2	91
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGP PIGU	1.46e-03	21	49	2	680
Coexpression	GSE39022_LN_VS_SPLEEN_DC_DN	PIGP GCLM JMJD8 RETREG1 TXNRD3 UTRN	1.28e-05	198	68	6	M9018
Coexpression	GSE22935_UNSTIM_VS_48H_MBOVIS_BCG_STIM_MYD88_KO_MACROPHAGE_DN	SLC6A18 PIGP JMJD8 DMD DGAT1 OPRM1	1.35e-05	200	68	6	M7774
Coexpression	GSE43955_TH0_VS_TGFB_IL6_IL23_TH17_ACT_CD4_TCELL_52H_DN	SART3 KLHDC2 UGCG RNFT1 NAV1 DGAT1	1.35e-05	200	68	6	M9653
Drug	bupivacaine	PRKD3 PRKD2 KCNH2 KCNJ5 PRKD1 DMD UTRN OPRM1	3.27e-09	125	67	8	CID000002474
Drug	1-stearoyl-2-arachidonylglycerol	PRKD3 PRKD2 KCNH2 PRKD1	9.12e-08	15	67	4	CID006443869
Drug	Doxazosin	KCNH6 KCNH7 KCNH2	4.84e-07	6	67	3	DB00590
Drug	Prazosin	KCNH6 KCNH7 KCNH2	4.84e-07	6	67	3	DB00457
Drug	Terazosin	KCNH6 KCNH7 KCNH2	4.84e-07	6	67	3	DB01162
Drug	loperamide	PRKD3 PRKD2 CACNA1S PRKD1 PKD1L3 OPRM1	6.62e-07	105	67	6	CID000003954
Drug	Miconazole	KCNH6 KCNH7 KCNH2	1.35e-06	8	67	3	DB01110
Drug	AC1L3G0K	PRKD3 PRKD2 CACNA1S PRKD1	1.77e-06	30	67	4	CID000114822
Drug	pimozide	KCNH6 CACNA1S KCNH7 KCNH2 PKD1L3 OPRM1	2.02e-06	127	67	6	CID000016362
Drug	Ibutilide	KCNH6 KCNH7 KCNH2	2.88e-06	10	67	3	DB00308
Drug	WAY-123,398	KCNH6 KCNH7 KCNH2	2.88e-06	10	67	3	CID000132160
Drug	HOE 694	PRKD3 PRKD2 SLC9A5 PRKD1	4.20e-06	37	67	4	CID000123840
Drug	AC1NPP2V	PRKD3 KCNH6 PRKD2 UGCG PRKD1	4.34e-06	82	67	5	CID005207744
Drug	diazoxide	PRKD3 KCNH6 PRKD2 KCNH7 KCNH2 KCNJ5 PRKD1	4.67e-06	227	67	7	CID000003019
Drug	barium	PRKD3 PRKD2 CACNA1S KCNH2 KCNJ5 PRKD1	4.91e-06	148	67	6	CID000104810
Drug	Bay K 8644	PRKD3 PRKD2 CACNA1S UTS2R PRKD1 PKD1L3	5.30e-06	150	67	6	CID000002303
Drug	AC1L1KEH	PRKD3 PRKD2 KCNH2 PRKD1	5.78e-06	40	67	4	CID000005462
Drug	tetracaine	PRKD3 PRKD2 CACNA1S MAOA PRKD1	6.15e-06	88	67	5	CID000005411
Drug	guanosine 3',5'-cyclic monophosphoric acid	PRKD3 PRKD2 CACNA1S PDE4C KCNH2 UGCG TXNRD3 PRKD1 DMD PKD1L3	6.84e-06	577	67	10	CID000000295
Drug	sodium dodecyl sulfate	PRKD3 PRKD2 GCLM DHDDS PRKD1	7.25e-06	91	67	5	CID000008778
Drug	rhodamine 6G	PRKD3 KCNH6 PRKD2 PRKD1	8.51e-06	44	67	4	CID000013806
Drug	N-(1-(2,3-dimethoxyphenyl)-4-methyl-3-penten-1-yl)-1-(5-bromofurfuryl)-1-piperidyl-4-amine	KCNH6 KCNH2	8.53e-06	2	67	2	ctd:C531033
Drug	NPC 15437	PRKD3 PRKD2 UTS2R PRKD1	1.02e-05	46	67	4	CID000004548
Drug	dansyl-DAG	PRKD3 PRKD2 PRKD1	1.08e-05	15	67	3	CID000129493
Drug	RK-1409B	PRKD3 PRKD2 PRKD1	1.08e-05	15	67	3	CID003036125
Drug	lavendustin A	PRKD3 PRKD2 CACNA1S KCNH2 PRKD1 PKD1L3	1.12e-05	171	67	6	CID000003894
Drug	verapamil	PRKD3 KCNH6 PRKD2 CACNA1S KCNH7 KCNH2 KCNJ5 PRKD1 PKD1L3	1.30e-05	490	67	9	CID000002520
Drug	ladostigil	PRKD3 PRKD2 MAOA PRKD1	1.31e-05	49	67	4	CID000208907
Drug	(S)-1,2-Diolein	PRKD3 PRKD2 PRKD1 DGAT1	1.42e-05	50	67	4	CID000001324
Drug	pyraclofos	KCNH6 CACNA1S KCNH7 KCNH2 NAV1	1.53e-05	106	67	5	CID000093460
Drug	AC1L1JQC	PRKD3 PRKD2 PRKD1	1.61e-05	17	67	3	CID000005157
Drug	daphnoretin	PRKD3 PRKD2 PRKD1	1.61e-05	17	67	3	CID005281406
Drug	sodium	SLC6A18 PRKD3 KCNH6 PRKD2 CACNA1S KCNH7 SLC9A5 KCNH2 KCNJ5 NAV1 PRKD1 ATP12A	1.76e-05	944	67	12	CID000000923
Drug	ziprasidone	KCNH6 KCNH7 KCNH2 KCNJ5	1.80e-05	53	67	4	CID000060853
Drug	dipalmitin	PRKD3 PRKD2 PRKD1	1.93e-05	18	67	3	CID000068149
Drug	Cgp-42700	PRKD3 PRKD2 PRKD1	1.93e-05	18	67	3	CID000188390
Drug	dihydrosterculic acid	PRKD3 PRKD2 PRKD1	1.93e-05	18	67	3	CID000160788
Drug	thiopental	PRKD3 PRKD2 CACNA1S PRKD1 DMD	1.99e-05	112	67	5	CID003000715
Drug	Ridauran	PRKD3 PRKD2 TXNRD3 PRKD1	2.09e-05	55	67	4	CID006333887
Drug	dihydropyridine	PRKD3 PRKD2 CACNA1S PRKD1 DMD PKD1L3	2.23e-05	193	67	6	CID000104822
Drug	TAPP-Br	PRKD3 PRKD2 PRKD1	2.28e-05	19	67	3	CID000160326
Drug	Hdba	KCNH6 KCNH7 KCNH2	2.28e-05	19	67	3	CID000003896
Drug	sapintoxin A	PRKD3 PRKD2 PRKD1	2.28e-05	19	67	3	CID000108085
Drug	MK-499	KCNH6 KCNH7 KCNH2	2.28e-05	19	67	3	CID000127718
Drug	lamotrigine	CACNA1S MAOA KCNH2 NAV1 PKD1L3	2.36e-05	116	67	5	CID000003878
Drug	AC1L1DXE	PRKD3 PRKD2 CACNA1S DHDDS PRKD1 PKD1L3 OPRM1	2.78e-05	299	67	7	CID000002548
Drug	KS-619-1	PRKD3 PRKD2 PRKD1	3.12e-05	21	67	3	CID000128369
Drug	K-259-2	PRKD3 PRKD2 PRKD1	3.12e-05	21	67	3	CID006438946
Drug	debromoaplysiatoxin	PRKD3 PRKD2 PRKD1	3.12e-05	21	67	3	CID000002967
Drug	broussochalcone A	PRKD3 PRKD2 PRKD1	3.12e-05	21	67	3	CID006438825
Drug	MDL 27,032	PRKD3 PRKD2 PRKD1	3.12e-05	21	67	3	CID000163812
Drug	vanadyl	PRKD3 PRKD2 DNAH3 PDE4C KCNJ5 DHDDS PRKD1	3.29e-05	307	67	7	CID000061671
Drug	ether-a	KCNH6 KCNH7 KCNH2	3.60e-05	22	67	3	CID000501025
Drug	nsc25485	PRKD3 PRKD2 SLC9A5 TXNRD3 PRKD1 ATP12A PKD1L3	3.65e-05	312	67	7	CID000004605
Drug	amiloride	PRKD3 PRKD2 CACNA1S SLC9A5 MAOA PRKD1 PKD1L3	3.88e-05	315	67	7	CID000016230
Drug	AC1L1ET5	PRKD3 PRKD2 KCNH2 PRKD1	4.05e-05	65	67	4	CID000002936
Drug	piperidine	KCNH6 KCNH7 KCNH2 DMD OPRM1	4.09e-05	130	67	5	CID000008082
Drug	AC1L4NFY	PRKD3 PRKD2 PRKD1	4.14e-05	23	67	3	CID000160335
Drug	ethoxytriethyleneglycol	PRKD3 PRKD2 PRKD1 TRRAP	4.30e-05	66	67	4	CID000008190
Drug	Barium permanganate	PRKD3 PRKD2 CACNA1S KCNJ5 PRKD1	4.56e-05	133	67	5	CID000024587
Drug	2-methylthioadenosine triphosphate	PRKD3 PRKD2 KCNJ5 PRKD1	4.84e-05	68	67	4	CID000001581
Drug	IDETA	DMD UTRN	5.10e-05	4	67	2	CID003036201
Drug	NS1643	KCNH6 KCNH2	5.10e-05	4	67	2	CID010177784
Drug	Methadyl Acetate	KCNH2 OPRM1	5.10e-05	4	67	2	ctd:D008692
Drug	4 alpha-phorbol 12,13-didecanoate	PRKD3 PRKD2 TXNRD3 PRKD1	5.43e-05	70	67	4	CID000452543
Drug	C-1b	PRKD3 PRKD2 PRKD1 CDC6	6.06e-05	72	67	4	CID006102740
Drug	AC1L1JVU	PRKD3 PRKD2 CACNA1S PRKD1	6.06e-05	72	67	4	CID000005229
Drug	3-(1H-pyrrole-2-carboxylate	PRKD3 PRKD2 CACNA1S KCNH2 PRKD1 DMD	6.38e-05	233	67	6	CID000005114
Drug	BCECF	PRKD3 PRKD2 SLC9A5 PRKD1	6.40e-05	73	67	4	CID004241719
Drug	beta-tocopherol	PRKD3 PRKD2 PRKD1	6.77e-05	27	67	3	CID000008989
Drug	ilmofosine	PRKD3 PRKD2 PRKD1	6.77e-05	27	67	3	CID000055008
Drug	C15720	PRKD3 PRKD2 PRKD1	6.77e-05	27	67	3	CID000003979
Drug	pseudohypericin	PRKD3 PRKD2 PRKD1	6.77e-05	27	67	3	CID005281751
Drug	tetraethylammonium	PRKD3 PRKD2 CACNA1S KCNH2 KCNJ5 PRKD1	6.85e-05	236	67	6	CID000005413
Drug	AC1L1JCO	PRKD3 PRKD2 OXA1L PRKD1	7.11e-05	75	67	4	CID000004982
Drug	R59022	PRKD3 PRKD2 TXNRD3 PRKD1	7.49e-05	76	67	4	CID000003012
Drug	bisindolylmaleimide II	PRKD3 PRKD2 PRKD1	7.57e-05	28	67	3	CID000002397
Drug	bisindolylmaleimide V	PRKD3 PRKD2 PRKD1	7.57e-05	28	67	3	CID000002400
Drug	aplysiatoxin	PRKD3 PRKD2 PRKD1	7.57e-05	28	67	3	CID000040465
Drug	HBDDE	PRKD3 PRKD2 PRKD1	7.57e-05	28	67	3	CID000003568
Drug	SC-10	PRKD3 PRKD2 PRKD1	7.57e-05	28	67	3	CID000005175
Drug	NCDC	PRKD3 PRKD2 PRKD1	7.57e-05	28	67	3	CID000001583
Drug	cerbroside	PRKD3 PRKD2 UGCG PRKD1	7.88e-05	77	67	4	CID000025437
Drug	6,9,12-octadecatrienoic acid	PRKD3 PRKD2 KLHDC2 PRKD1	8.29e-05	78	67	4	CID000003453
Drug	miltefosine	PRKD3 PRKD2 OXA1L PRKD1	8.29e-05	78	67	4	CID000003599
Drug	AC1Q6DXY	PRKD3 PRKD2 PRKD1	8.43e-05	29	67	3	CID000003719
Drug	AC1L1B58	PRKD3 PRKD2 PRKD1	8.43e-05	29	67	3	CID000001288
Drug	Polychlorinated biphenyls	PRKD3 PRKD2 PRKD1	8.43e-05	29	67	3	CID000006636
Drug	thioridazine	KCNH6 KCNH7 KCNH2 KCNJ5	8.72e-05	79	67	4	CID000005452
Drug	procaine	PRKD3 PRKD2 CACNA1S PRKD1 PKD1L3	8.86e-05	153	67	5	CID000004914
Drug	Gf 109	PRKD3 PRKD2 PRKD1	9.34e-05	30	67	3	CID000196144
Drug	12-deoxyphorbol 13-phenylacetate	PRKD3 PRKD2 PRKD1	9.34e-05	30	67	3	CID000105100
Drug	HMBA	PRKD3 PRKD2 PRKD1 IL1RL1 TRRAP	1.00e-04	157	67	5	CID000003616
Drug	plakin	SYNE3 DHDDS DMD UTRN	1.01e-04	82	67	4	CID000018752
Drug	N,n,n-tms	PRKD3 PRKD2 PRKD1	1.03e-04	31	67	3	CID006439410
Drug	lidocaine	PRKD3 PRKD2 CACNA1S PRKD1 DMD	1.09e-04	160	67	5	CID000003676
Drug	magnesium	PRKD3 PRKD2 CACNA1S DNAH3 FNTB KCNH2 KCNJ5 DHDDS PRKD1 CDC6 ATP12A DGAT1 OPRM1	1.11e-04	1325	67	13	CID000000888
Drug	CGS 9343B	PRKD3 PRKD2 PRKD1	1.25e-04	33	67	3	CID000065909
Drug	naphthalenesulfonamide	PRKD3 PRKD2 PRKD1	1.25e-04	33	67	3	CID000163571
Drug	AC1L1FGW	PRKD3 PRKD2 PRKD1	1.25e-04	33	67	3	CID000003231
Disease	long QT syndrome (implicated_via_orthology)	KCNH6 KCNH7 KCNH2	1.33e-06	10	67	3	DOID:2843 (implicated_via_orthology)
Disease	short QT syndrome (implicated_via_orthology)	KCNH6 KCNH2	1.52e-05	3	67	2	DOID:0050793 (implicated_via_orthology)
Disease	heart conduction disease (implicated_via_orthology)	KCNH6 KCNH7 KCNH2	5.29e-05	32	67	3	DOID:10273 (implicated_via_orthology)
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1S DMD UTRN	7.57e-05	36	67	3	DOID:11723 (implicated_via_orthology)
Disease	Psychotic Disorders	KCNH6 MAOA KCNH2 OPRM1	8.40e-05	101	67	4	C0033975
Disease	candidiasis (implicated_via_orthology)	PRKD3 PRKD2 PRKD1	1.39e-04	44	67	3	DOID:1508 (implicated_via_orthology)
Disease	Congenital long QT syndrome	KCNH2 KCNJ5	2.76e-04	11	67	2	cv:C1141890
Disease	Long QT syndrome	KCNH2 KCNJ5	3.30e-04	12	67	2	cv:C0023976
Disease	Methionine sulfoxide measurement	KCNH6 SLC15A4	3.30e-04	12	67	2	EFO_0021650
Disease	Respiratory Depression	CACNA1S OPRM1	3.90e-04	13	67	2	C0235063
Disease	Hepatic Encephalopathy	MAOA OPRM1	3.90e-04	13	67	2	C0019151
Disease	Hepatic Coma	MAOA OPRM1	3.90e-04	13	67	2	C0019147
Disease	Respiratory Insufficiency	CACNA1S OPRM1	3.90e-04	13	67	2	C0035229
Disease	Respiratory Failure	CACNA1S OPRM1	3.90e-04	13	67	2	C1145670
Disease	Fulminant Hepatic Failure with Cerebral Edema	MAOA OPRM1	3.90e-04	13	67	2	C0751197
Disease	Hepatic Stupor	MAOA OPRM1	3.90e-04	13	67	2	C0751198
Disease	alkaline phosphatase measurement	PRKD2 PDE4C CATSPER2 FAM167A DHDDS PKD1L3 UTRN DGAT1 SENP7	4.65e-04	1015	67	9	EFO_0004533
Disease	epilepsy (implicated_via_orthology)	KCNH6 KCNH7 KCNH2 ATP12A	5.25e-04	163	67	4	DOID:1826 (implicated_via_orthology)
Disease	Nonorganic psychosis	KCNH6 KCNH2 OPRM1	5.27e-04	69	67	3	C0349204
Disease	Romano-Ward Syndrome	KCNH2 KCNJ5	5.97e-04	16	67	2	C0035828
Disease	muscular dystrophy (implicated_via_orthology)	DMD UTRN	1.04e-03	21	67	2	DOID:9884 (implicated_via_orthology)
Disease	Psychoses, Drug	GCLM OPRM1	1.04e-03	21	67	2	C0033937
Disease	Seizures	PIGP PIGU TRRAP OPRM1	1.54e-03	218	67	4	C0036572

Protein segments in the cluster

Peptide	Gene	Start	Entry
LYPEEILDTHWELWK	CTSK	16	P43235
LEFWVQALISQHLWY	EPG5	1146	Q9HCE0
LDHWYALLQDVWKVP	CATSPER2	296	Q96P56
DIQAHEWVPLWLLRY	GCLM	236	P48507
YLELHWDFQSWVPLL	ANKRD13C	226	Q8N6S4
LEEVWACWHELLSYL	DMD	1261	P11532
WLVPLHYDLELWPQL	LVRN	101	Q6Q4G3
LAVPNHLIWLIFFYW	DGAT1	326	O75907
GSLLVWHVDWLDEYQ	DMXL1	501	Q9Y485
FDWSLHFKWEQIPLE	GALNT16	261	Q8N428
VLWLPHWGLYIFSLA	RFT1	171	Q96AA3
FIWWLIAYIRGDLDH	KCNJ5	106	P48544
QPLSWYPEELAWHTN	NSUN2	116	Q08J23
PHEVSALWFLWYVKQ	MAOA	186	P21397
TADPLDYRLSWHLWE	NUP98	1516	P52948
LTFSHPTWYWENLLK	OPRM1	221	P35372
HPWLQDYQTWLDLRE	PRKD1	836	Q15139
APFSPVLHYWLLLWD	LRRN4CL	106	Q8ND94
VLHYWLLLWDGSEAA	LRRN4CL	111	Q8ND94
DLDYTLWPFWVDTHV	MDP1	11	Q86V88
LHYSPFKAVWDWLIL	KCNH7	401	Q9NS40
AQYWFVAVPHAILIW	ATP12A	1001	P54707
LHYSPFKAVWDWLIL	KCNH2	401	Q12809
HYSPFKAVWDWLILL	KCNH6	251	Q9H252
IDYIAHPLWETWADL	PDE4C	601	Q08493
SLSHPWLQEYQTWLD	PRKD2	801	Q9BZL6
SLSHPWLQDYQTWLD	PRKD3	826	O94806
LFYPWQDWALGVLHA	MARCHF6	756	O60337
WWFQDLTVSDPIYIL	OXA1L	251	Q15070
SLLFPVLWHLWIYAG	PIGU	366	Q9H490
FWQQVLDPAWHLLFD	METTL7A	186	Q9H8H3
WEKLYTWHFAEVPVL	PALB2	906	Q86YC2
IDLYNWTAPLEWFKN	IL1RL1	136	Q01638
PIELLRQWIDHGYWF	DNAH3	2156	Q8TD57
WKLIYDSAWPHEEQL	DNAH3	3446	Q8TD57
TLGPLVAQLHAWWYF	GLT6D1	186	Q7Z4J2
KHSYWLDLWLFILFD	C4orf3	41	Q8WVX3
GNEWPWIYFVTLILL	CACNA1S	306	Q13698
IYIFLSALWDPTISW	UGCG	361	Q16739
VLYTLFEWPWLSNSH	CDC6	296	Q99741
AHPIIFWNLLWYFQR	DENND4B	1296	O75064
PWLCYWILHSLELLD	FNTB	101	P49356
HYLNLDTWEWNELIP	KLHDC2	246	Q9Y2U9
LWPEYTFWNLFEAIL	DHDDS	231	Q86SQ9
IFPLTEELWLEWLHD	SART3	141	Q15020
AADLSLWWQVPQYLL	SLC15A4	446	Q8N697
WLWEPPGYLHSSLFL	FAM87A	61	P0C7U9
FILYLVWAFIPESWL	PIGP	51	P57054
LIWTYDAPHLGYWIA	FAM171B	316	Q6P995
WFLNPLKSARYFLWH	OTOF	1946	Q9HC10
YLEWQARLEEHTWPF	FAM167A	46	Q96KS9
LDWVPKLWYHLHTFL	NAV1	1716	Q8NEY1
VWSCWIELLHYLDLE	UTRN	1231	P46939
WYLAVICFPWLEEAV	SENP7	861	Q9BQF6
VWLHWSEYLLARDEF	SYNE3	111	Q6ZMZ3
FWFLALTPWRVYHLI	RETREG1	106	Q9H6L5
YLWLSIATRHPWNQF	PKD1L3	886	Q7Z443
FYILHPKFIWQLWDI	ST6GAL2	406	Q96JF0
WHEVEAPYLVALWIL	SLC9A5	41	Q14940
DLTYVYQWPWTLLLL	SLC35E1	251	Q96K37
WVLWYLLNSFQHPLP	SLC6A18	121	Q96N87
LAWLDLQAPGEAHYW	SNF8	221	Q96H20
WTDPALPLENQVWYH	SHF	311	Q7M4L6
NPTLDHLSFWEVFWI	RNFT1	236	Q5M7Z0
WPLWYIELALASLFS	TMEM209	61	Q96SK2
FLPFWLWQLLAQYHQ	UTS2R	271	Q9UKP6
ENLEIYHTLFWPLEW	TXNRD3	541	Q86VQ6
WINDLENDDLYITWP	UGGT2	446	Q9NYU1
WLAWLIHVGESLYAI	TMEM254	66	Q8TBM7
PAIFPEYQLWEDHWI	TRRAP	2811	Q9Y4A5
VLLPAAAWHYLVSWY	USP11	156	P51784
YFPDRWWHATLNLDT	JMJD8	241	Q96S16