Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	DSP PKP2	2.22e-04	5	95	2	GO:0086083
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	2.22e-04	5	95	2	GO:0140444
GeneOntologyCellularComponent	supramolecular fiber	HAUS6 MYO1A DSP SYNE1 SPTAN1 MYO1B TUBGCP5 DNAH1 DPP9 SYNE2 PKP2 RP1 DNAH6 ATP2B4 MX1	3.01e-04	1179	96	15	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	HAUS6 MYO1A DSP SYNE1 SPTAN1 MYO1B TUBGCP5 DNAH1 DPP9 SYNE2 PKP2 RP1 DNAH6 ATP2B4 MX1	3.23e-04	1187	96	15	GO:0099081
GeneOntologyCellularComponent	presynaptic active zone membrane	P2RX2 AFDN ATP2B2 ATP2B4	4.59e-04	78	96	4	GO:0048787
GeneOntologyCellularComponent	nuclear outer membrane	SYNE1 SLC22A3 SYNE2	8.20e-04	40	96	3	GO:0005640
GeneOntologyCellularComponent	inner dynein arm	DNAH1 DNAH6	9.17e-04	10	96	2	GO:0036156
GeneOntologyCellularComponent	cell-cell contact zone	DSP SPTAN1 PKP2 AFDN	9.29e-04	94	96	4	GO:0044291
GeneOntologyCellularComponent	microtubule organizing center attachment site	SYNE1 SYNE2	1.12e-03	11	96	2	GO:0034992
GeneOntologyCellularComponent	meiotic nuclear membrane microtubule tethering complex	SYNE1 SYNE2	1.12e-03	11	96	2	GO:0034993
GeneOntologyCellularComponent	nuclear membrane protein complex	SYNE1 SYNE2	1.12e-03	11	96	2	GO:0106083
GeneOntologyCellularComponent	nuclear membrane microtubule tethering complex	SYNE1 SYNE2	1.12e-03	11	96	2	GO:0106094
GeneOntologyCellularComponent	fascia adherens	DSP SPTAN1	1.58e-03	13	96	2	GO:0005916
Domain	Spectrin_repeat	DSP SYNE1 SPTAN1 CCDC141 SYNE2	2.66e-07	29	91	5	IPR002017
Domain	Spectrin	SYNE1 SPTAN1 CCDC141 SYNE2	4.35e-06	23	91	4	PF00435
Domain	Spectrin/alpha-actinin	DSP SYNE1 SPTAN1 SYNE2	1.71e-05	32	91	4	IPR018159
Domain	SPEC	DSP SYNE1 SPTAN1 SYNE2	1.71e-05	32	91	4	SM00150
Domain	-	FBXW10B FBXW10 BIRC6 WDFY4 TBL3 DMXL1 WDR97 SEMA5B WDR89	3.55e-05	333	91	9	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	FBXW10B FBXW10 BIRC6 WDFY4 TBL3 DMXL1 WDR97 SEMA5B WDR89	3.72e-05	335	91	9	IPR015943
Domain	TIR	TLR8 TLR1 TLR3	1.40e-04	21	91	3	SM00255
Domain	ATP_Ca_trans_C	ATP2B2 ATP2B4	1.40e-04	4	91	2	IPR022141
Domain	KASH	SYNE1 SYNE2	1.40e-04	4	91	2	PF10541
Domain	KASH	SYNE1 SYNE2	1.40e-04	4	91	2	IPR012315
Domain	ATP_Ca_trans_C	ATP2B2 ATP2B4	1.40e-04	4	91	2	PF12424
Domain	KASH	SYNE1 SYNE2	1.40e-04	4	91	2	PS51049
Domain	P-type_ATPase_IIB	ATP2B2 ATP2B4	1.40e-04	4	91	2	IPR006408
Domain	KASH	SYNE1 SYNE2	1.40e-04	4	91	2	SM01249
Domain	TIR	TLR8 TLR1 TLR3	1.61e-04	22	91	3	PF01582
Domain	-	TLR8 TLR1 TLR3	1.85e-04	23	91	3	3.40.50.10140
Domain	LRR_8	ISLR2 ERBIN OMG TLR8 TLR1 TLR3	1.89e-04	171	91	6	PF13855
Domain	TIR	TLR8 TLR1 TLR3	2.10e-04	24	91	3	PS50104
Domain	Leu-rich_rpt_typical-subtyp	ISLR2 ERBIN OMG TLR8 TLR1 TLR3	2.28e-04	177	91	6	IPR003591
Domain	LRR_TYP	ISLR2 ERBIN OMG TLR8 TLR1 TLR3	2.28e-04	177	91	6	SM00369
Domain	TIR_dom	TLR8 TLR1 TLR3	2.38e-04	25	91	3	IPR000157
Domain	ARM-type_fold	USP34 CUL7 WDFY4 VIRMA PIK3CD PKP2 ATM ARMH3	2.49e-04	339	91	8	IPR016024
Domain	WD40	FBXW10B FBXW10 WDFY4 TBL3 DMXL1 WDR97 WDR89	2.73e-04	259	91	7	PF00400
Domain	WD40	FBXW10B FBXW10 WDFY4 TBL3 DMXL1 WDR97 WDR89	3.36e-04	268	91	7	SM00320
Domain	WD40_repeat	FBXW10B FBXW10 WDFY4 TBL3 DMXL1 WDR97 WDR89	3.67e-04	272	91	7	IPR001680
Domain	WD_REPEATS_1	FBXW10B FBXW10 WDFY4 TBL3 DMXL1 WDR97 WDR89	4.19e-04	278	91	7	PS00678
Domain	WD_REPEATS_2	FBXW10B FBXW10 WDFY4 TBL3 DMXL1 WDR97 WDR89	4.28e-04	279	91	7	PS50082
Domain	WD_REPEATS_REGION	FBXW10B FBXW10 WDFY4 TBL3 DMXL1 WDR97 WDR89	4.28e-04	279	91	7	PS50294
Domain	LRR	ISLR2 ERBIN OMG TLR8 TLR1 TLR3	4.50e-04	201	91	6	PS51450
Domain	Myosin_TH1	MYO1A MYO1B	4.85e-04	7	91	2	PF06017
Domain	APC_su10/DOC_dom	MYCBP2 CUL7	4.85e-04	7	91	2	IPR004939
Domain	DOC	MYCBP2 CUL7	4.85e-04	7	91	2	PS51284
Domain	Myosin_TH1	MYO1A MYO1B	4.85e-04	7	91	2	IPR010926
Domain	TH1	MYO1A MYO1B	4.85e-04	7	91	2	PS51757
Domain	APC10	MYCBP2 CUL7	4.85e-04	7	91	2	SM01337
Domain	ANAPC10	MYCBP2 CUL7	4.85e-04	7	91	2	PF03256
Domain	WD40_repeat_dom	FBXW10B FBXW10 WDFY4 TBL3 DMXL1 WDR97 WDR89	6.20e-04	297	91	7	IPR017986
Domain	LRR_1	ISLR2 ERBIN OMG TLR8 TLR1 TLR3	7.06e-04	219	91	6	PF00560
Domain	Cys-rich_flank_reg_C	ISLR2 TLR8 TLR1 TLR3	9.79e-04	90	91	4	IPR000483
Domain	LRRCT	ISLR2 TLR8 TLR1 TLR3	9.79e-04	90	91	4	SM00082
Domain	WD40_repeat_CS	FBXW10B FBXW10 WDFY4 TBL3 WDR97	1.24e-03	164	91	5	IPR019775
Domain	EH	SYNRG ITSN2	1.25e-03	11	91	2	PS50031
Domain	EH	SYNRG ITSN2	1.25e-03	11	91	2	SM00027
Domain	EH_dom	SYNRG ITSN2	1.25e-03	11	91	2	IPR000261
Domain	Dynein_heavy_chain_D4_dom	DNAH1 DNAH6	2.06e-03	14	91	2	IPR024317
Domain	Dynein_HC_stalk	DNAH1 DNAH6	2.06e-03	14	91	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH1 DNAH6	2.06e-03	14	91	2	IPR013602
Domain	DHC_N2	DNAH1 DNAH6	2.06e-03	14	91	2	PF08393
Domain	MT	DNAH1 DNAH6	2.06e-03	14	91	2	PF12777
Domain	AAA_8	DNAH1 DNAH6	2.06e-03	14	91	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH1 DNAH6	2.06e-03	14	91	2	IPR011704
Domain	AAA_5	DNAH1 DNAH6	2.06e-03	14	91	2	PF07728
Domain	Leu-rich_rpt	ISLR2 ERBIN OMG TLR8 TLR1 TLR3	2.10e-03	271	91	6	IPR001611
Domain	Spectrin_alpha_SH3	SPTAN1 ITSN2	2.37e-03	15	91	2	IPR013315
Domain	DHC_fam	DNAH1 DNAH6	2.37e-03	15	91	2	IPR026983
Domain	Dynein_heavy_dom	DNAH1 DNAH6	2.37e-03	15	91	2	IPR004273
Domain	Dynein_heavy	DNAH1 DNAH6	2.37e-03	15	91	2	PF03028
Domain	PI3/4_kinase_CS	PIK3CD ATM	2.37e-03	15	91	2	IPR018936
Domain	-	ATP2B2 ATP2B4	2.70e-03	16	91	2	1.20.1110.10
Domain	-	PIK3CD ATM	2.70e-03	16	91	2	1.10.1070.11
Domain	ATPase_P-typ_TM_dom	ATP2B2 ATP2B4	2.70e-03	16	91	2	IPR023298
Domain	PI3Kc	PIK3CD ATM	2.70e-03	16	91	2	SM00146
Domain	ATPase_P-typ_cation-transptr_C	ATP2B2 ATP2B4	3.04e-03	17	91	2	IPR006068
Domain	Cation_ATPase_C	ATP2B2 ATP2B4	3.04e-03	17	91	2	PF00689
Domain	PI3/4_kinase_cat_dom	PIK3CD ATM	3.41e-03	18	91	2	IPR000403
Domain	Cation_ATPase_N	ATP2B2 ATP2B4	3.41e-03	18	91	2	PF00690
Domain	PI3_PI4_kinase	PIK3CD ATM	3.41e-03	18	91	2	PF00454
Domain	Cation_ATPase_N	ATP2B2 ATP2B4	3.41e-03	18	91	2	SM00831
Domain	PI3_4_KINASE_3	PIK3CD ATM	3.41e-03	18	91	2	PS50290
Domain	PI3_4_KINASE_1	PIK3CD ATM	3.41e-03	18	91	2	PS00915
Domain	PI3_4_KINASE_2	PIK3CD ATM	3.41e-03	18	91	2	PS00916
Domain	ATPase_P-typ_cation-transptr_N	ATP2B2 ATP2B4	3.80e-03	19	91	2	IPR004014
Domain	-	ISLR2 ERBIN OMG TLR8 TLR1 TLR3	4.83e-03	321	91	6	3.80.10.10
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 MYCBP2 DSP SPTAN1 MYO1B PSMD12 CUL7 BIRC6 VIRMA TBL3 SYNE2 AFDN ATM	3.99e-08	653	98	13	22586326
Pubmed	Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.	TLR8 TLR1 TLR3	1.20e-06	8	98	3	20100933
Pubmed	Polymorphism in 3'-untranslated region of toll-like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation.	TLR8 TLR1 TLR3	1.80e-06	9	98	3	20977567
Pubmed	Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.	TLR8 TLR1 TLR3	1.80e-06	9	98	3	24091496
Pubmed	Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.	TLR8 TLR1 TLR3	2.57e-06	10	98	3	20227302
Pubmed	A family of human receptors structurally related to Drosophila Toll.	TLR8 TLR1 TLR3	2.57e-06	10	98	3	9435236
Pubmed	[Expression of toll-like receptors in human epidermal keratinocytes].	TLR8 TLR1 TLR3	2.57e-06	10	98	3	18686608
Pubmed	Toll-like receptors.	TLR8 TLR1 TLR3	2.57e-06	10	98	3	11782555
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	FOXM1 UGT1A10 GBE1 GCKR BIRC6 TLR1 EHMT1 KDR	3.07e-06	313	98	8	20800603
Pubmed	Toll-like receptors.	TLR8 TLR1 TLR3	3.52e-06	11	98	3	18394314
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SYNRG HAUS6 MYCBP2 DSP SPTAN1 ERBIN ASH2L JMJD1C TMEM33 AFDN	3.58e-06	549	98	10	38280479
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 MYCBP2 SYNE1 BIRC6 ERBIN SYNE2 EHMT1	3.63e-06	225	98	7	12168954
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	HAUS6 RIPK1 DSP MYO1B PSMD12 ANKRD50 ERBIN JMJD1C TMEM33 PKP2 AFDN	5.18e-06	708	98	11	39231216
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	MYCBP2 PSMD12 DMXL1 SLF2 SYNE2	6.49e-06	92	98	5	15840729
Pubmed	YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes.	TLR8 TLR1 TLR3	7.72e-06	14	98	3	34206257
Pubmed	A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.	GCKR JMJD1C ZBTB10	7.72e-06	14	98	3	22829776
Pubmed	Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.	TLR8 TLR1 TLR3	7.72e-06	14	98	3	20595247
Pubmed	LncRNA RP1-276N6.2 Expression and RP1-276N6.2 Gene Polymorphisms Contribute to the Risk of Coronary Artery Disease in Chinese Han Population.	SLC22A3 RP1	7.86e-06	2	98	2	37843894
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	7.86e-06	2	98	2	11792814
Pubmed	Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases.	RIPK1 AFDN	7.86e-06	2	98	2	37828052
Pubmed	N6-methyladenosine (m6A) writer KIAA1429 accelerates gastric cancer oxaliplatin chemoresistance by targeting FOXM1.	FOXM1 VIRMA	7.86e-06	2	98	2	36326914
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	7.86e-06	2	98	2	24931616
Pubmed	GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling.	ADGRG6 KDR	7.86e-06	2	98	2	25217645
Pubmed	Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region.	ATP2B2 ATP2B4	7.86e-06	2	98	2	1313367
Pubmed	Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2.	ATP2B2 ATP2B4	7.86e-06	2	98	2	22252018
Pubmed	Erbin alleviates sepsis-induced cardiomyopathy by inhibiting RIPK1-dependent necroptosis through activating PKA/CREB pathway.	RIPK1 ERBIN	7.86e-06	2	98	2	39216682
Pubmed	Plasma membrane Ca²⁺-ATPases can shape the pattern of Ca²⁺ transients induced by store-operated Ca²⁺ entry.	ATP2B2 ATP2B4	7.86e-06	2	98	2	25690014
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	7.86e-06	2	98	2	22768332
Pubmed	Ubiquitin-specific protease 34 in macrophages limits CD8 T cell-mediated onset of vitiligo in mice.	USP34 ATM	7.86e-06	2	98	2	37043976
Pubmed	FBXW10 promotes hepatocarcinogenesis in male patients and mice.	FBXW10B FBXW10	7.86e-06	2	98	2	31400758
Pubmed	Epicardial Ventricular Tachycardia Ablation in a Patient With Brugada ECG Pattern and Mutation of PKP2 and DSP Genes.	DSP PKP2	7.86e-06	2	98	2	25900994
Pubmed	Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma.	RIPK1 TLR3	7.86e-06	2	98	2	33036630
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	7.86e-06	2	98	2	17267447
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	7.86e-06	2	98	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	7.86e-06	2	98	2	24586179
Pubmed	Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.	FBXW10B FBXW10	7.86e-06	2	98	2	37450367
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	7.86e-06	2	98	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	7.86e-06	2	98	2	31578382
Pubmed	Activation of Toll-like receptors inhibits herpes simplex virus-1 infection of human neuronal cells.	TLR8 TLR3	7.86e-06	2	98	2	19437550
Pubmed	Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines.	ATP2B2 ATP2B4	7.86e-06	2	98	2	16216224
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HAUS6 CUL7 TUBGCP5 BIRC6 WDFY4 JMJD1C SACS TLR1 NCEH1	1.11e-05	493	98	9	15368895
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SYNE1 ANKRD50 BIRC6 ERBIN ITSN2	1.13e-05	103	98	5	10574462
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MYCBP2 DSP SYNE1 ANKRD50 CCDC141 BIRC6 ASH2L JMJD1C SYNE2	1.18e-05	497	98	9	23414517
Pubmed	Expression of Toll-like receptors in the developing brain.	TLR8 TLR1 TLR3	1.18e-05	16	98	3	22666391
Pubmed	Natural selection in the TLR-related genes in the course of primate evolution.	TLR8 TLR1 TLR3	1.18e-05	16	98	3	18810425
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FOXM1 SYNRG UBE4B MYCBP2 DSP SPTAN1 VIRMA ERBIN AFDN PLCB3 ATM	1.19e-05	774	98	11	15302935
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP34 HAUS6 DSCAM ANKRD50 BIRC6 ERBIN DMXL1 FAF2 EHMT1 PKP2 AFDN	1.24e-05	777	98	11	35844135
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYO1A DSP SPTAN1 MYO1B PSMD12 TMEM33 FAF2 NCEH1 ATP2B4 MX1	1.49e-05	647	98	10	26618866
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MYCBP2 SYNE1 SPTAN1 ERBIN TBL3 TMEM33 DMXL1 MRPS10 FAF2 DPP9 SACS SYNE2 EHMT1 ATM ATP2B4	1.76e-05	1487	98	15	33957083
Pubmed	Toll-like receptor signaling pathway variants and prostate cancer mortality.	TLR8 TLR1 TLR3	2.03e-05	19	98	3	19505919
Pubmed	Toll-like receptor 3 and 7/8 function is impaired in hepatitis C rapid fibrosis progression post-liver transplantation.	TLR8 TLR3	2.35e-05	3	98	2	23425350
Pubmed	Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents.	FOXM1 ATM	2.35e-05	3	98	2	34545188
Pubmed	IFNs activate toll-like receptor gene expression in viral infections.	TLR8 TLR1	2.35e-05	3	98	2	11607792
Pubmed	Myosin I can act as a molecular force sensor.	MYO1A MYO1B	2.35e-05	3	98	2	18599791
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	2.35e-05	3	98	2	16079285
Pubmed	The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy.	DSP PKP2	2.35e-05	3	98	2	24276085
Pubmed	Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.	TLR8 TLR3	2.35e-05	3	98	2	16935934
Pubmed	Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.	TLR8 TLR3	2.35e-05	3	98	2	19164128
Pubmed	KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.	FOXM1 VIRMA	2.35e-05	3	98	2	39060874
Pubmed	Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells.	TLR1 TLR3	2.35e-05	3	98	2	10820283
Pubmed	Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family.	MYO1A MYO1B	2.35e-05	3	98	2	8449986
Pubmed	Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population.	TLR8 TLR3	2.35e-05	3	98	2	24445780
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	2.35e-05	3	98	2	10878022
Pubmed	The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.	RIPK1 TLR3	2.35e-05	3	98	2	27270888
Pubmed	ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance.	FOXM1 ATM	2.35e-05	3	98	2	21518729
Pubmed	Modulation of TLR 3, 7 and 8 expressions in HCV genotype 3 infected individuals: potential correlations of pathogenesis and spontaneous clearance.	TLR8 TLR3	2.35e-05	3	98	2	25126563
Pubmed	Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1.	RIPK1 TLR3	2.35e-05	3	98	2	36310878
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	2.35e-05	3	98	2	12408964
Pubmed	Toll-Like Receptor mRNA Levels in Schizophrenia: Association With Complement Factors and Cingulate Gyrus Cortical Thinning.	TLR8 TLR3	2.35e-05	3	98	2	38102721
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE1 SYNE2	2.35e-05	3	98	2	17462627
Pubmed	The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection.	TLR8 TLR3	2.35e-05	3	98	2	29947302
Pubmed	Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.	TLR8 TLR3	2.35e-05	3	98	2	16111635
Pubmed	The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells.	ATP2B2 ATP2B4	2.35e-05	3	98	2	17689535
Pubmed	Endothelial nitric oxide synthase activity is inhibited by the plasma membrane calcium ATPase in human endothelial cells.	ATP2B2 ATP2B4	2.35e-05	3	98	2	20211863
Pubmed	Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly.	DSP PKP2	2.35e-05	3	98	2	18474624
Pubmed	Contribution of Toll like receptor polymorphisms to dengue susceptibility and clinical outcome among eastern Indian patients.	TLR8 TLR3	2.35e-05	3	98	2	31481269
Pubmed	Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants.	TLR8 TLR3	2.35e-05	3	98	2	27729782
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	SYNE1 SYNE2	2.35e-05	3	98	2	33472039
Pubmed	Arrhythmogenic right ventricular dysplasia.	DSP PKP2	2.35e-05	3	98	2	18596851
Pubmed	Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.	SYNE1 SYNE2	2.35e-05	3	98	2	25516977
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	DSCAM MYCBP2 VIRMA TBL3 AFDN ATP2B2	2.41e-05	202	98	6	24639526
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBE4B MYCBP2 DSP SPTAN1 MYO1B BIRC6 ERBIN TBL3 TOE1 TMEM33 FAF2 ZBTB10 PKP2 AFDN	2.62e-05	1353	98	14	29467282
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SYNRG MYCBP2 DSP SPTAN1 VIRMA ERBIN FSIP2 SLF2 SYNE2 PKP2 AFDN	3.18e-05	861	98	11	36931259
Pubmed	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors.	TLR8 TLR1 TLR3	3.21e-05	22	98	3	31729371
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	DSP SPTAN1 MYO1B OMG ATP2B2	3.60e-05	131	98	5	28634551
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	DSP SYNE1 SPTAN1 MYO1B VIRMA DMXL1 EHMT1	4.55e-05	333	98	7	32665550
Pubmed	Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.	ATP2B2 ATP2B4	4.70e-05	4	98	2	12209837
Pubmed	Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.	TLR8 TLR3	4.70e-05	4	98	2	21515789
Pubmed	Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.	ATP2B2 ATP2B4	4.70e-05	4	98	2	12784250
Pubmed	SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.	SYNE1 SYNE2	4.70e-05	4	98	2	16648470
Pubmed	Arrhythmogenic right ventricular dysplasia: clinical characteristics and identification of novel desmosome gene mutations.	DSP PKP2	4.70e-05	4	98	2	18632414
Pubmed	Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1.	RIPK1 TLR3	4.70e-05	4	98	2	18442983
Pubmed	The plasma membrane calcium pump in health and disease.	ATP2B2 ATP2B4	4.70e-05	4	98	2	23413890
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B2 ATP2B4	4.70e-05	4	98	2	8245032
Pubmed	Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs.	TLR8 TLR3	4.70e-05	4	98	2	29777026
Pubmed	Association of Toll-like receptor polymorphisms with HIV status in North Americans.	TLR8 TLR1	4.70e-05	4	98	2	25253287
Pubmed	Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico.	TLR8 TLR3	4.70e-05	4	98	2	33138336
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B2 ATP2B4	4.70e-05	4	98	2	7989379
Pubmed	Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.	TLR8 MX1	4.70e-05	4	98	2	32740454
Pubmed	Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.	ATP2B2 ATP2B4	4.70e-05	4	98	2	11152753
Interaction	NUP43 interactions	USP34 DSCAM DSP CUL7 VIRMA JMJD1C TBL3 USP44 FSIP2 SLF2 SYNE2 ZBTB10 EHMT1	7.34e-06	625	95	13	int:NUP43
Interaction	SIRT7 interactions	USP34 MYCBP2 DSP SPTAN1 MYO1B PSMD12 CUL7 BIRC6 VIRMA TBL3 SYNE2 AFDN ELK4 ATM	9.91e-06	744	95	14	int:SIRT7
Interaction	HERC2P9 interactions	HAUS6 RIPK1 BIRC6 PKP2	1.16e-05	30	95	4	int:HERC2P9
GeneFamily	CD molecules\|Toll like receptors	TLR8 TLR1 TLR3	7.12e-06	10	72	3	948
GeneFamily	WD repeat domain containing	FBXW10B FBXW10 WDFY4 TBL3 DMXL1 WDR97 WDR89	8.17e-05	262	72	7	362
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	9.34e-05	4	72	2	1252
GeneFamily	Myosins, class I	MYO1A MYO1B	4.31e-04	8	72	2	1097
GeneFamily	ATPases Ca2+ transporting	ATP2B2 ATP2B4	5.53e-04	9	72	2	1209
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW10B FBXW10	8.40e-04	11	72	2	559
GeneFamily	Dyneins, axonemal	DNAH1 DNAH6	2.05e-03	17	72	2	536
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	USP34 SYNRG HAUS6 MYCBP2 SYNE1 SPTAN1 HECTD4 BIRC6 ERBIN JMJD1C TRANK1 SACS SLF2 PIK3CD ITSN2 ELK4 ATM ATP2B4	6.98e-06	1492	96	18	M40023
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 VIRMA ERBIN TRANK1 SLF2 SYNE2 ATP2B4 MX1	5.25e-09	177	97	8	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 VIRMA ERBIN TRANK1 SLF2 SYNE2 ATP2B4 MX1	5.25e-09	177	97	8	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	SYNE1 VIRMA ERBIN TRANK1 SLF2 SYNE2 ATP2B4 MX1	5.25e-09	177	97	8	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 VIRMA ERBIN TRANK1 SLF2 SYNE2 ATP2B4 MX1	5.25e-09	177	97	8	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE1 VIRMA ERBIN TRANK1 SLF2 SYNE2 ATP2B4 MX1	5.25e-09	177	97	8	d5aeda113afaa2425874394610344570c9078478
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 MYCBP2 BIRC6 JMJD1C SYNE2 ITSN2 ATM MX1	1.36e-08	200	97	8	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	COVID-19_Moderate-multiplets\|COVID-19_Moderate / disease group, cell group and cell class	SYNE1 GCKR ADGRG6 SYNE2 TLR3 PKP2 SH2D7	3.46e-08	147	97	7	baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM DNAH1 TRANK1 WDR89 RP1 DNAH6 ATP2B2	9.00e-08	169	97	7	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTAN1 VIRMA ERBIN TRANK1 SYNE2 AFDN MX1	1.49e-07	182	97	7	c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTAN1 VIRMA ERBIN TRANK1 SYNE2 AFDN MX1	1.49e-07	182	97	7	4cb182ef39be2044a6ad7266f332d4177591e550
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SYNE1 SLC22A23 HECTD4 MYO1B TUBGCP5 SLC22A3	1.72e-06	166	97	6	89e2b8453180983533faccb4275867861876d7ee
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXW10 CUL7 SLF2 RAVER2 AFDN MX1	2.19e-06	173	97	6	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	ICU-NoSEP-Myeloid-cDC1\|ICU-NoSEP / Disease, Lineage and Cell Type	FBXW10 WDFY4 ADGRG6 TLR3 PKP2 STRA6	2.50e-06	177	97	6	33cd2c183ee8b597012efcbcae72131ac6beaf4e
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC22A23 JMJD1C SEMA5B FCN2 SYNE2 KDR	2.76e-06	180	97	6	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ISLR2 CUL7 DNAH1 GXYLT2 SACS STRA6	2.76e-06	180	97	6	c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCell	droplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1B SACS SYNE2 AFDN KDR ELK4	2.85e-06	181	97	6	92d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPTAN1 VIRMA ERBIN TRANK1 SYNE2 MX1	2.94e-06	182	97	6	1aea96ee211f7b9caef7fd385233f51be6021a73
ToppCell	droplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1B SACS SYNE2 AFDN KDR ELK4	2.94e-06	182	97	6	81279877b920b5a1bc991a07d3031d6458700fe3
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPTAN1 VIRMA ERBIN TRANK1 SYNE2 MX1	2.94e-06	182	97	6	b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCell	COVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated\|COVID-19_Mild / Disease group, lineage and cell class	SPTAN1 VIRMA ERBIN TRANK1 SYNE2 MX1	3.03e-06	183	97	6	7717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	SYNE1 VIRMA ERBIN TRANK1 SLF2 MX1	3.03e-06	183	97	6	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 BIRC6 ERBIN JMJD1C SLF2 ITSN2	3.13e-06	184	97	6	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SACS SYNE2 AFDN KDR ELK4 ATP2B4	3.33e-06	186	97	6	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 DSP MYO1B ERBIN SYNE2 NCEH1	3.88e-06	191	97	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 DSP MYO1B ERBIN SYNE2 NCEH1	3.88e-06	191	97	6	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 DSP MYO1B ERBIN SYNE2 NCEH1	3.88e-06	191	97	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SYNE1 SLC22A23 MYO1B CCDC141 SLC22A3 AFDN	4.24e-06	194	97	6	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	Mild/Remission-B_activate-7\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYCBP2 DSP JMJD1C TRANK1 ZBTB10 MX1	4.24e-06	194	97	6	01c97543972159a9468272da06e7e611e2c21fae
ToppCell	COVID_non-vent-Lymphocytic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SYNRG SYNE1 SPTAN1 TRANK1 SYNE2 ATM	4.63e-06	197	97	6	c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCell	COVID_vent-Lymphocytic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	SYNRG SYNE1 SPTAN1 TRANK1 SYNE2 ATM	4.77e-06	198	97	6	ee80f647317377081b4bd194ee2801f556b3a53b
ToppCell	healthy_donor-Lymphocytic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	SYNRG SYNE1 SPTAN1 SYNE2 ATM ATP2B4	4.91e-06	199	97	6	2841e16d54acd344ba454f024e285c28abc37319
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T\|COVID-19_Mild / Disease, condition lineage and cell class	SYNRG SPTAN1 CCDC141 TRANK1 SYNE2 ATP2B4	4.91e-06	199	97	6	f307d4887b28cf60a591439e278fd668409cb104
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	USP34 SPTAN1 BIRC6 SYNE2 AFDN KDR	5.05e-06	200	97	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 TRANK1 SYNE2 ATM ATP2B4 MX1	5.05e-06	200	97	6	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPTAN1 ANKRD50 SYNE2 AFDN KDR MX1	5.05e-06	200	97	6	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	COVID-19-kidney-Mito-rich_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SYNE1 SLC22A23 FCN2 SYNE2 KDR	1.65e-05	145	97	5	afed661aef990edb8e7012ab67ace56443520c9f
ToppCell	VE-CD8-antiviral_CD4\|VE / Condition, Cell_class and T cell subcluster	MYO1B OMG TLR3 CCDC163 MX1	1.82e-05	148	97	5	f49f579650b57cc4c6c7a7fa726447740d3dc695
ToppCell	Control-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DSP WDFY4 VIRMA ERBIN ARMH3	2.27e-05	155	97	5	0a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBXW10 TOE1 GXYLT2 SACS ATP2B2	2.57e-05	159	97	5	9f6607e395bcca9cb1c83199bdbbaaa62a93938d
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	WDFY4 ERBIN SLF2 PIK3CD ARMH3	2.57e-05	159	97	5	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBXW10 TOE1 GXYLT2 SACS ATP2B2	2.57e-05	159	97	5	c8b42ebc25ebcc450832096fbffaa5c5f5fe88e7
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	SYNE1 SLC22A23 HECTD4 MYO1B SLC22A3	2.81e-05	162	97	5	2259e9536147e9cdee772e3a30ba7d104573262c
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	WDFY4 ADGRG6 RAVER2 TLR3 PKP2	2.89e-05	163	97	5	a09449a502627aa369db600dba5bda93de7ce5c0
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	WDFY4 ADGRG6 RAVER2 TLR3 PKP2	2.98e-05	164	97	5	ed888b55d9c685096fd785878fcb264f4fee88d6
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	WDFY4 ERBIN TRANK1 SLF2 AFDN	3.25e-05	167	97	5	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ISLR2 B3GNT5 SEMA5B SLC22A3 ATP2B4	3.34e-05	168	97	5	3fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCell	Control-B_naive-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DSP VIRMA ERBIN SLF2 ARMH3	3.63e-05	171	97	5	d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 SYNE2 ITSN2 KDR ELK4	4.40e-05	178	97	5	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH1 WDR97 RP1 DNAH6 CDHR4	4.40e-05	178	97	5	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	RSV-Healthy-0\|RSV / Virus stimulation, Condition and Cluster	USP34 VPS25 TLR1 SYNE2 MX1	4.64e-05	180	97	5	974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCell	RSV-Healthy-0\|Healthy / Virus stimulation, Condition and Cluster	USP34 VPS25 TLR1 SYNE2 MX1	4.64e-05	180	97	5	703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCell	Healthy-multiplets\|World / disease group, cell group and cell class	WDFY4 ADGRG6 RAVER2 TLR3 PKP2	4.76e-05	181	97	5	f8dbac3cd500cc8d80853312b00d124c27b8fd85
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	USP34 SPTAN1 JMJD1C SYNE2 ATM	4.76e-05	181	97	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 MYCBP2 JMJD1C ITSN2 ELK4	4.89e-05	182	97	5	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	droplet-Spleen-nan-18m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 MYCBP2 JMJD1C ITSN2 ELK4	5.02e-05	183	97	5	28cbf909424f3be4491d49832f0aca0386560814
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	DSP JMJD1C TRANK1 SYNE2 MX1	5.02e-05	183	97	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DSP WDFY4 DMXL1 TRANK1 MX1	5.02e-05	183	97	5	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT5 MYCBP2 JMJD1C ITSN2 ELK4	5.02e-05	183	97	5	3fa608aa6b119869ec3280dc388dfee57160e63a
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	WDFY4 TLR8 TLR1 CDHR4	5.12e-05	93	97	4	1a112bd4e5e63826efad0338ce99d7a7ad9c72b9
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	WDFY4 TLR8 TLR1 CDHR4	5.12e-05	93	97	4	9c566fc2a8c7630bea28e8e46df55454aa409bc1
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	WDFY4 TLR8 TLR1 CDHR4	5.12e-05	93	97	4	d102a0a015a2866e3fe549ac8796b9a0d5923d7e
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	WDFY4 TLR8 TLR1 CDHR4	5.12e-05	93	97	4	0967a93dcc72d2d8f12d56de186ec1af55c36001
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	WDFY4 TLR8 TLR1 CDHR4	5.12e-05	93	97	4	613c827a643a7b6d70ef932cfa1762e90bc5a338
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 ERBIN JMJD1C TLR8 ITSN2	5.28e-05	185	97	5	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	SLC22A23 HECTD4 R3HDM2 SLF2 SCMH1	5.42e-05	186	97	5	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	SLC22A23 HECTD4 R3HDM2 SLF2 SCMH1	5.42e-05	186	97	5	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	Control-B_intermediate-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	WDFY4 TRANK1 SACS ITSN2 MX1	5.85e-05	189	97	5	11cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 OMG RP1 DNAH6 CDHR4	5.99e-05	190	97	5	9ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 OMG RP1 DNAH6 CDHR4	5.99e-05	190	97	5	833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCell	Mild/Remission-B_activate-7\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DSP JMJD1C TRANK1 ZBTB10 MX1	6.15e-05	191	97	5	382686d62f7b8576c44bb9726a4e10dc26fd348e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 SPTAN1 SYNE2 ATP2B4 CCDC107	6.15e-05	191	97	5	4a29b7d5cd10e9077699d3aa76e3db6c4d5a0cf6
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	SYNE1 MYO1B CCDC141 SLC22A3 SYNE2	6.30e-05	192	97	5	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 OMG RP1 DNAH6 CDHR4	6.30e-05	192	97	5	be592e661367affced9ebe80849b466e6adb3a34
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 SYNE2 AFDN NCEH1 RP1	6.46e-05	193	97	5	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 OMG RP1 DNAH6 CDHR4	6.46e-05	193	97	5	0b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKRD50 AFDN KDR ATP2B4 MX1	6.46e-05	193	97	5	a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 SYNE2 AFDN NCEH1 RP1	6.46e-05	193	97	5	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 OMG RP1 DNAH6 CDHR4	6.61e-05	194	97	5	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNE1 OMG RP1 DNAH6 CDHR4	6.61e-05	194	97	5	7a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCell	COVID-19-kidney-Glomerular_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SYNE1 SLC22A23 FCN2 SYNE2 KDR	6.61e-05	194	97	5	660535b492445063d965095a50e1e299ce04c50a
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FBXW10 SYNE1 RP1 DNAH6 CDHR4	6.61e-05	194	97	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	SYNE1 SLC22A23 SYNE2 RP1 DNAH6	6.78e-05	195	97	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	SYNE1 SLC22A23 MYO1B SYNE2 ATP2B4	6.78e-05	195	97	5	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	COVID-19_Mild-PLT_5\|COVID-19_Mild / Disease Group and Platelet Clusters	SYNRG SPTAN1 SYNE2 ATP2B4 MX1	6.78e-05	195	97	5	bdf9a6ea1bd83c72a834c45f86ce3f4643a9bef3
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	DSP DMXL1 TRANK1 ELK4 MX1	6.78e-05	195	97	5	b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	SYNE1 SLC22A23 SYNE2 RP1 DNAH6	6.78e-05	195	97	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	SYNE1 SLC22A23 MYO1B SYNE2 ATP2B4	6.78e-05	195	97	5	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SYNE1 SLC22A23 MYO1B SLC22A3 AFDN	6.78e-05	195	97	5	9406866f99555198a9be311fbd65751b70f35446
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	SYNE1 ERBIN SYNE2 ATM ATP2B4	6.78e-05	195	97	5	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	SYNE1 SYNE2 RP1 DNAH6 CDHR4	6.94e-05	196	97	5	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 ERBIN SYNE2 ATM ATP2B4	6.94e-05	196	97	5	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 ERBIN SYNE2 ATM ATP2B4	6.94e-05	196	97	5	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	SYNE1 SYNE2 RP1 DNAH6 CDHR4	6.94e-05	196	97	5	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE1 ERBIN SYNE2 ATM ATP2B4	6.94e-05	196	97	5	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SYNE1 OMG RP1 DNAH6 CDHR4	6.94e-05	196	97	5	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 ERBIN SYNE2 ATM ATP2B4	6.94e-05	196	97	5	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SYNE1 TRANK1 SYNE2 ATM ATP2B4	7.11e-05	197	97	5	836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 TRANK1 SYNE2 TRAV23DV6 MX1	7.11e-05	197	97	5	0b4fdf0131dd67a86ee3209fa66db0ca2e01a10e
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SYNE1 TUBGCP5 SYNE2 ATM	7.11e-05	197	97	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SYNE1 OMG RP1 DNAH6 CDHR4	7.11e-05	197	97	5	71fea4aa6ce96c7693fa94792d08770622873850
Disease	urate measurement, bone density	DSCAM UBE4B UGT1A10 SYNE1 GBE1 ERBIN DNAH1 FSIP2 GXYLT2 ATP2B2 ATP2B4	3.66e-06	619	92	11	EFO_0003923, EFO_0004531
Disease	Paroxysmal atrial fibrillation	USP34 UBE4B SCMH1 SYNE2 PKP2 ARMH3	9.72e-06	156	92	6	C0235480
Disease	familial atrial fibrillation	USP34 UBE4B SCMH1 SYNE2 PKP2 ARMH3	9.72e-06	156	92	6	C3468561
Disease	Persistent atrial fibrillation	USP34 UBE4B SCMH1 SYNE2 PKP2 ARMH3	9.72e-06	156	92	6	C2585653
Disease	Atrial Fibrillation	USP34 UBE4B SCMH1 SYNE2 PKP2 ARMH3	1.12e-05	160	92	6	C0004238
Disease	free androgen index	UBE4B UGT1A10 R3HDM2 GCKR JMJD1C SLC22A3 ATP2B2 ATP2B4	2.28e-05	374	92	8	EFO_0007005
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	R3HDM2 GCKR JMJD1C SYNE2 PLCB3	3.95e-05	121	92	5	EFO_0008595, EFO_0020943
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	R3HDM2 GCKR JMJD1C DNAH1 SYNE2 PLCB3	3.95e-05	200	92	6	EFO_0004611, EFO_0020945
Disease	testosterone measurement	FOXM1 HAUS6 DSCAM UGT1A10 R3HDM2 GCKR BIRC6 JMJD1C GSS SLC22A3 SYNE2 ZBTB10 ATP2B2 ATP2B4	3.97e-05	1275	92	14	EFO_0004908
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	R3HDM2 GCKR JMJD1C SYNE2 PLCB3	4.97e-05	127	92	5	EFO_0008595, EFO_0020947
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	5.75e-05	4	92	2	cv:CN293514
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	R3HDM2 GCKR DNAH1 SLC22A3 SYNE2 PLCB3	7.41e-05	224	92	6	EFO_0004530, EFO_0008317
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	9.56e-05	5	92	2	C1450051
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	9.56e-05	5	92	2	C0410190
Disease	triglyceride measurement, phospholipid measurement	R3HDM2 GCKR JMJD1C DNAH1 PLCB3	9.63e-05	146	92	5	EFO_0004530, EFO_0004639
Disease	cholesteryl esters to total lipids in large LDL percentage	GCKR JMJD1C SLC22A3	1.24e-04	31	92	3	EFO_0022249
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	1.43e-04	6	92	2	cv:C0410189
Disease	low density lipoprotein cholesterol measurement, body mass index	GCKR SLC22A3	1.43e-04	6	92	2	EFO_0004340, EFO_0004611
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	1.43e-04	6	92	2	C0410189
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B2 ATP2B4	1.43e-04	6	92	2	DOID:0050429 (implicated_via_orthology)
Disease	atrial fibrillation	USP34 UBE4B JMJD1C SCMH1 SYNE2 PKP2 ARMH3	1.64e-04	371	92	7	EFO_0000275
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	FOXM1 HECTD4 GCKR JMJD1C SYNE2 PLCB3	1.82e-04	264	92	6	EFO_0008317, EFO_0020944
Disease	Arrhythmogenic right ventricular cardiomyopathy	DSP PKP2	2.00e-04	7	92	2	cv:C0349788
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	2.00e-04	7	92	2	C0751337
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	R3HDM2 GCKR JMJD1C PLCB3	2.27e-04	95	92	4	EFO_0004529, EFO_0008317, EFO_0008596
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	R3HDM2 GCKR BIRC6 JMJD1C DNAH1 PLCB3	2.31e-04	276	92	6	EFO_0004612, EFO_0020943
Disease	cups of coffee per day measurement	HECTD4 GCKR STRA6	2.67e-04	40	92	3	EFO_0006782
Disease	primary immunodeficiency disease (is_implicated_in)	TLR8 DPP9 TLR3	3.08e-04	42	92	3	DOID:612 (is_implicated_in)
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	GCKR JMJD1C SYNE2 PLCB3	3.09e-04	103	92	4	EFO_0008595, EFO_0020944
Disease	triglycerides in large LDL measurement	GCKR SLC22A3 SYNE2	3.31e-04	43	92	3	EFO_0022319
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	R3HDM2 GCKR JMJD1C PLCB3	3.45e-04	106	92	4	EFO_0008317, EFO_0008596
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement	R3HDM2 GCKR JMJD1C PLCB3	3.83e-04	109	92	4	EFO_0004639, EFO_0008317, EFO_0008596
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	R3HDM2 GCKR JMJD1C PLCB3	3.97e-04	110	92	4	EFO_0008317, EFO_0008596, EFO_0010351
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	R3HDM2 GCKR JMJD1C PLCB3	3.97e-04	110	92	4	EFO_0008317, EFO_0008591, EFO_0008596
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	R3HDM2 GCKR JMJD1C PLCB3	3.97e-04	110	92	4	EFO_0004574, EFO_0008317, EFO_0008596
Disease	Human papillomavirus infectious disease (is_marker_for)	TLR3 MX1	4.26e-04	10	92	2	DOID:11166 (is_marker_for)
Disease	arrhythmogenic right ventricular cardiomyopathy (is_implicated_in)	DSP PKP2	4.26e-04	10	92	2	DOID:0050431 (is_implicated_in)
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	R3HDM2 GCKR DNAH1 SYNE2 PLCB3	4.75e-04	206	92	5	EFO_0004612, EFO_0020947
Disease	level of Ceramide (d40:1) in blood serum	GCKR SYNE2	5.19e-04	11	92	2	OBA_2045185
Disease	follistatin measurement	R3HDM2 GCKR	5.19e-04	11	92	2	EFO_0010614
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	6.22e-04	12	92	2	DOID:11726 (implicated_via_orthology)
Disease	alcohol consumption measurement, alcohol drinking	HECTD4 GCKR	6.22e-04	12	92	2	EFO_0004329, EFO_0007878
Disease	puberty onset measurement	GCKR BIRC6 JMJD1C SLF2	6.43e-04	125	92	4	EFO_0005677
Disease	fibrinogen measurement, factor VII measurement	HECTD4 GCKR JMJD1C	7.99e-04	58	92	3	EFO_0004619, EFO_0004623
Disease	very low density lipoprotein particle size measurement	FOXM1 GCKR JMJD1C PLCB3	8.11e-04	133	92	4	EFO_0008594
Disease	triglycerides to total lipids in small LDL percentage	GCKR JMJD1C PLCB3	8.40e-04	59	92	3	EFO_0022337
Disease	Hamman-Rich syndrome	DSP DPP9	8.54e-04	14	92	2	C0085786
Disease	diacylglycerol 42:7 measurement	SYNE2 WDR89	8.54e-04	14	92	2	EFO_0020068
Disease	liver volume	GCKR JMJD1C	9.83e-04	15	92	2	EFO_0600048
Disease	YKL40 measurement	GCKR ATP2B4	9.83e-04	15	92	2	EFO_0004869
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	R3HDM2 GCKR JMJD1C DNAH1 PLCB3	9.99e-04	243	92	5	EFO_0004612, EFO_0020944
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	GCKR JMJD1C SYNE2 PLCB3	1.09e-03	144	92	4	EFO_0004611, EFO_0020943
Disease	cholesterol in large VLDL measurement	GCKR JMJD1C SLC22A3	1.11e-03	65	92	3	EFO_0021902
Disease	triacylglycerol 50:5 measurement	MYO1B GCKR	1.12e-03	16	92	2	EFO_0010412
Disease	behavioural inhibitory control measurement	ZBTB10 STRA6	1.12e-03	16	92	2	EFO_0008467
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	PIK3CD ATM	1.12e-03	16	92	2	C0334634
Disease	breast carcinoma (is_marker_for)	AFDN KDR ATM	1.16e-03	66	92	3	DOID:3459 (is_marker_for)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	CUL7 SYNE2 KDR ATM	1.21e-03	148	92	4	C0279702
Disease	interstitial lung disease	DSP GBE1 DPP9	1.22e-03	67	92	3	EFO_0004244
Disease	hemoglobin A1 measurement	SLC22A23 GCKR JMJD1C SLC22A3 SYNE2 PLCB3 ATP2B4	1.22e-03	520	92	7	EFO_0007629
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	GCKR JMJD1C SYNE2 PLCB3	1.27e-03	150	92	4	EFO_0004611, EFO_0020947
Disease	low density lipoprotein cholesterol measurement, body fat percentage	UGT1A10 SLC22A3	1.27e-03	17	92	2	EFO_0004611, EFO_0007800
Disease	sphingomyelin 14:0 measurement	SYNE2 WDR89	1.27e-03	17	92	2	EFO_0010390
Disease	level of Sphingomyelin (d32:1) in blood serum	SYNE2 WDR89	1.27e-03	17	92	2	OBA_2045173
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR1 TLR3	1.27e-03	17	92	2	DOID:8677 (biomarker_via_orthology)
Disease	triglycerides in very small VLDL measurement	R3HDM2 GCKR SLC22A3	1.27e-03	68	92	3	EFO_0022144
Disease	triglycerides to phosphoglycerides ratio	GCKR JMJD1C PLCB3	1.27e-03	68	92	3	EFO_0022327
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	GCKR SEMA5B MX1	1.32e-03	69	92	3	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	very low density lipoprotein cholesterol measurement	R3HDM2 GCKR JMJD1C SLC22A3 PLCB3	1.35e-03	260	92	5	EFO_0008317
Disease	Contact Dermatitis	PSMD12 TLR8 GSS	1.44e-03	71	92	3	C0011616
Disease	Contact hypersensitivity	PSMD12 TLR8 GSS	1.44e-03	71	92	3	C0162351
Disease	triglycerides to total lipids in small HDL percentage	GCKR JMJD1C PLCB3	1.50e-03	72	92	3	EFO_0022336
Disease	cancer (implicated_via_orthology)	PSMD12 VPS25 PIK3CD KDR ATM	1.54e-03	268	92	5	DOID:162 (implicated_via_orthology)
Disease	Usual Interstitial Pneumonia	DSP DPP9	1.59e-03	19	92	2	C4721509
Disease	Hamman-Rich Disease	DSP DPP9	1.59e-03	19	92	2	C4721508
Disease	triglyceride measurement, body mass index	GCKR SLC22A3	1.59e-03	19	92	2	EFO_0004340, EFO_0004530
Disease	reticulocyte measurement	USP34 HECTD4 MYO1B GCKR BIRC6 JMJD1C SYNE2 AFDN PLCB3 ATP2B4	1.64e-03	1053	92	10	EFO_0010700
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	SEMA5B MX1	1.76e-03	20	92	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	Familial Idiopathic Pulmonary Fibrosis	DSP DPP9	1.76e-03	20	92	2	C4721952
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	R3HDM2 GCKR SYNE2 PLCB3	1.84e-03	166	92	4	EFO_0004530, EFO_0004611
Disease	urate measurement	USP34 HECTD4 R3HDM2 GCKR BIRC6 JMJD1C DNAH1 SLC22A3 PLCB3	1.92e-03	895	92	9	EFO_0004531
Disease	prothrombin time measurement	GCKR JMJD1C	1.94e-03	21	92	2	EFO_0008390
Disease	systemising measurement	DSCAM PIK3CD	1.94e-03	21	92	2	EFO_0010221
Disease	Idiopathic Pulmonary Fibrosis	DSP DPP9	1.94e-03	21	92	2	C1800706
Disease	alcohol drinking	HECTD4 GCKR TLR1	2.10e-03	81	92	3	EFO_0004329
Disease	phosphatidylcholine 34:3 measurement	MYO1B GCKR	2.13e-03	22	92	2	EFO_0010377
Disease	bilirubin measurement	UGT1A10 GCKR ANKRD50 BIRC6 JMJD1C ATP2B4	2.63e-03	442	92	6	EFO_0004570
Disease	cholelithiasis	UGT1A10 GCKR JMJD1C	2.66e-03	88	92	3	EFO_0004799
Disease	coronary artery calcification	PSMD12 GCKR FSIP2 TLR1 ARMH3 DNAH6	2.88e-03	450	92	6	EFO_0004723
Disease	anogenital venereal wart (is_marker_for)	TLR8 TLR3	2.98e-03	26	92	2	DOID:11168 (is_marker_for)
Disease	maximal oxygen uptake measurement	CCDC141 ERBIN	2.98e-03	26	92	2	EFO_0004887
Disease	uric acid measurement	USP34 DSCAM HECTD4 GCKR ANKRD50 BIRC6 SLC22A3	3.00e-03	610	92	7	EFO_0004761

Protein segments in the cluster

Peptide	Gene	Start	Entry
WMANASELLNFIKQD	AFDN	691	P55196
LSGLKEFWMDANRLT	ERBIN	206	Q96RT1
SFTKLQQLTAMWLSD	ERBIN	386	Q96RT1
LLDQELFELLFNWSM	BIRC6	3516	Q9NR09
RLWNFTMNAKILSNL	ADGRG6	311	Q86SQ4
WTKANYTLLLLQMCN	FBXW10	131	Q5XX13
LWSALINLLKFLMSN	ARMH3	496	Q5T2E6
NSNLQLETAELALWM	ANKRD50	461	Q9ULJ7
MNTSLSWFEQLDVLL	CCDC163	1	A0A0D9SF12
VLLSEWSKNADMLFS	DMXL1	481	Q9Y485
LWASAKLNLTMNVQL	CDHR4	316	A6H8M9
LWVNLIMDTFASLAL	ATP2B2	911	Q01814
LWVNLIMDTFASLAL	ATP2B4	876	P23634
KEMCLSALANLTWQS	ASH2L	166	Q9UBL3
WSDLRNLSALQLLKM	ISLR2	116	Q6UXK2
LFTQLAMSGAKIQWL	R3HDM2	886	Q9Y2K5
SALFAQWMDVNLLAS	RAVER2	211	Q9HCJ3
ALIFVNWKELIMSNT	ITSN2	1251	Q9NZM3
AMELLWLQQAINSRK	IQCC	171	Q4KMZ1
WTKANYTLLLLQMCN	FBXW10B	131	O95170
LLFRDLLQAMWKAQH	MYO1A	526	Q9UBC5
MNISLWKAESISLDF	JMJD1C	2201	Q15652
KNITVSWLNEMNTLF	FSIP2	3996	Q5CZC0
WKLMLLDATFRGAQQ	NCEH1	31	Q6PIU2
STVQMWLLLYLNDLK	CUL7	1466	Q14999
WKLLRLFNSTQLAAM	GXYLT2	226	A0PJZ3
KVLNLALMFADGWQA	TUBGCP5	956	Q96RT8
NDWSQKLNSLMSLVN	PSMD12	426	O00232
LAMAFAEQLLSWKSE	HECTD4	2696	Q9Y4D8
SNSKLFWRALAMLQR	GCKR	511	Q14397
SFLCDWILLTFMNKN	P2RX2	356	Q9UBL9
WSEELFKLAMNILAQ	PLCB3	131	Q01970
YNLTLKLLMQFSWAN	B3GNT5	166	Q9BYG0
LNTQELWTKALKFML	BECN2	401	A8MW95
SFSHWLRLKMENEQL	DNAH1	2126	Q9P2D7
KELQWTFIMLTYLNN	ATM	1706	Q13315
NNLTLEWKDGLMALS	DNAH6	1806	Q9C0G6
DQALVGDKSLAFWLM	GBE1	481	Q04446
LAGAQQELLNMKLWT	CCDC107	141	Q8WV48
SLQFILDLRQKWNDM	CCDC141	716	Q6ZP82
MDSAITLWQFLLQLL	ELK4	1	P28324
SNMKQSWLIFLDTTL	LINC00473	106	A8K010
LLLSWKQMLDHFQAT	DPP9	101	Q86TI2
LLSFLGMAWALQAAD	FCN2	16	Q15485
EAILALWNQLYINMK	DSP	531	P15924
TKNFTMNWLLCQESL	DPY19L4	391	Q7Z388
LSNIQWLRKMSSDGL	FOXM1	181	Q08050
SLWASVNETLMFLEK	HAUS6	236	Q7Z4H7
MATNWGSLLQDKQQL	GSS	1	P48637
AWMLDLTQAILNLGF	SLC22A3	151	O75751
QLMLWVLENLSSLKN	SACS	1011	Q9NZJ4
LNSQVWSALQMSKAL	EHMT1	981	Q9H9B1
AWLLVLNLKGSMNSF	RP1	1131	P56715
LKSLIMALSNSSWRL	OR52L2P	11	Q8NGH6
MWILALSLFQSFANV	DSCAM	1	O60469
MWLAANLSIFYLLKI	TAS2R50	96	P59544
LLLSTNMKWVQFSNL	MRPS10	36	P82664
QQLQSVKDMWASLLS	SYNE1	3361	Q8NF91
LRASLAQFEQKWTML	SYNE2	5026	Q8WXH0
DKVWNNLIGFMSLAT	SYNRG	1206	Q9UMZ2
SLRWLMATQQFESAK	SLC22A23	366	A1A5C7
MKSWNNTIILEFLLL	OR7A10	1	O76100
LINTRMLFWACSTNK	FAF2	201	Q96CS3
SSLQQMALRCWSLKF	MYCBP2	3671	O75592
FQSLLINLMKNIRDW	SLF2	961	Q8IX21
DLGLASFKMWSKLNN	RIPK1	156	Q13546
LWNMSAANNNIKLLD	OMG	101	P23515
WLTLALAVILQNMAA	STRA6	476	Q9BX79
LNASSWPMFLLKTLN	SCMH1	131	Q96GD3
WTKSLLSLNMSSNIL	TLR1	421	Q15399
SMSFKNLSMLLLLTW	ALG10	241	Q5BKT4
INDNMLKFFNWTLLQ	TLR8	671	Q9NR97
NLEWLDKSKSSFLIM	VPS25	86	Q9BRG1
LKWTNLTMLDLSYNN	TLR3	271	O15455
AQWKAQAQSIFSLLM	UGT1A10	96	Q9HAW8
MWQALKLLFCATGLQ	SLC35B2	106	Q8TB61
QAAAFLDFLWHNMKL	TBL3	776	Q12788
LLVAEMNSSLALWQF	WDR97	211	A6NE52
LMKRWSQLLANSAAR	SPTAN1	2061	Q13813
FMLNFLWVLQQLSTK	UBE4B	686	O95155
LWMNTADNLELSLFS	WDFY4	1471	Q6ZS81
FQKAWSSMLRLSLSD	TTC41P	881	Q6P2S7
ATAAFNKDALLNWLK	PIK3CD	846	O00329
QALAELQELALKWFM	SH2D7	21	A6NKC9
LLEDTWTTFMKARLN	SEMA5B	331	Q9P283
LDTLWKLNATMFSNS	KDR	606	P35968
SLMQKLQCSFQTSWL	ZBTB10	241	Q96DT7
LYLASMLIKALWNNA	USP34	461	Q70CQ2
MLIKALWNNALAAKA	USP34	466	Q70CQ2
ALLVFWDARMNSQNL	WDR89	141	Q96FK6
MDKILGASFLVLWLQ	TRAV23DV6	1	A0A075B6W5
ESTDLWLSAMQAFLL	TRANK1	2281	O15050
MTFLFRNGSLQEKLW	PXMP4	51	Q9Y6I8
LANNTWSLMLKEVLS	VIRMA	1086	Q69YN4
LWNLSSNDKLKNLMI	PKP2	506	Q99959
SNNFKEMWPSLLLAI	TOE1	41	Q96GM8
FLKLDLNQWLAMTAS	USP44	301	Q9H0E7
NKLDTAMWLSRLFTV	TMEM33	21	P57088
NDLLYRDLSQAMWKA	MYO1B	531	O43795
MLQLLQDKDTYSWLL	MX1	616	P20591