Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sweet taste receptor activity	TAS1R3 TAS1R2	1.71e-05	2	83	2	GO:0033041
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of sweet taste	TAS1R3 TAS1R2	1.60e-05	2	83	2	GO:0001582
GeneOntologyCellularComponent	sweet taste receptor complex	TAS1R3 TAS1R2	1.60e-05	2	84	2	GO:1903767
GeneOntologyCellularComponent	taste receptor complex	TAS1R3 TAS1R2	1.60e-05	2	84	2	GO:1903768
Domain	EGF	PCSK5 SNED1 MFGE8 DLK2 LAMC2 VWCE ADAM22 STAB1	8.14e-06	235	81	8	SM00181
Domain	EGF-like_dom	PCSK5 SNED1 MFGE8 DLK2 LAMC2 VWCE ADAM22 STAB1	1.24e-05	249	81	8	IPR000742
Domain	EGF_1	SNED1 MFGE8 DLK2 LAMC2 VWCE ADAM22 STAB1	1.20e-04	255	81	7	PS00022
Domain	EGF-like_CS	SNED1 MFGE8 DLK2 LAMC2 VWCE ADAM22 STAB1	1.38e-04	261	81	7	IPR013032
Domain	EGF_2	SNED1 MFGE8 DLK2 LAMC2 VWCE ADAM22 STAB1	1.52e-04	265	81	7	PS01186
Domain	EGF_3	SNED1 MFGE8 DLK2 VWCE ADAM22 STAB1	5.50e-04	235	81	6	PS50026
Domain	NCD3G	TAS1R3 TAS1R2	1.40e-03	13	81	2	PF07562
Domain	GPCR_3_9-Cys_dom	TAS1R3 TAS1R2	1.40e-03	13	81	2	IPR011500
Domain	GPCR_3_CS	TAS1R3 TAS1R2	1.63e-03	14	81	2	IPR017979
Domain	EGF_CA	SNED1 DLK2 VWCE STAB1	1.96e-03	122	81	4	SM00179
Domain	EGF-like_Ca-bd_dom	SNED1 DLK2 VWCE STAB1	2.08e-03	124	81	4	IPR001881
Domain	EGF	SNED1 MFGE8 DLK2 STAB1	2.20e-03	126	81	4	PF00008
Domain	EGF_extracell	DLK2 ADAM22 STAB1	2.25e-03	60	81	3	IPR013111
Domain	EGF_2	DLK2 ADAM22 STAB1	2.25e-03	60	81	3	PF07974
Domain	PLAC	PCSK5 ADAMTS7	3.03e-03	19	81	2	PS50900
Domain	PLAC	PCSK5 ADAMTS7	3.03e-03	19	81	2	IPR010909
Domain	GPCR_3	TAS1R3 TAS1R2	3.70e-03	21	81	2	IPR000337
Domain	7tm_3	TAS1R3 TAS1R2	4.06e-03	22	81	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	TAS1R3 TAS1R2	4.06e-03	22	81	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	TAS1R3 TAS1R2	4.06e-03	22	81	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	TAS1R3 TAS1R2	4.06e-03	22	81	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	TAS1R3 TAS1R2	4.06e-03	22	81	2	PS50259
Domain	GPCR_3_C	TAS1R3 TAS1R2	4.06e-03	22	81	2	IPR017978
Domain	Claudin_CS	CLDN3 CLDN1	4.06e-03	22	81	2	IPR017974
Domain	CLAUDIN	CLDN3 CLDN1	4.06e-03	22	81	2	PS01346
Domain	Growth_fac_rcpt_	PCSK5 LAMC2 VWCE STAB1	4.73e-03	156	81	4	IPR009030
Domain	Claudin	CLDN3 CLDN1	6.53e-03	28	81	2	IPR006187
Domain	hEGF	SNED1 DLK2	6.53e-03	28	81	2	PF12661
Domain	VWC	BMPER VWCE	6.53e-03	28	81	2	PF00093
Domain	EGF_LAM_2	LAMC2 STAB1	7.47e-03	30	81	2	PS50027
Domain	EGF_LAM_1	LAMC2 STAB1	7.47e-03	30	81	2	PS01248
Domain	EGF_Ca-bd_CS	SNED1 DLK2 VWCE	8.65e-03	97	81	3	IPR018097
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC16A3 SLC47A1 SLC39A4 SLC30A10 SLC6A14	2.97e-05	76	67	5	MM15072
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC16A3 SLC47A1 SLC39A4 SLC30A10 SLC6A14	4.81e-05	84	67	5	M27334
Pubmed	Metformin Combining PD-1 Inhibitor Enhanced Anti-Tumor Efficacy in STK11 Mutant Lung Cancer Through AXIN-1-Dependent Inhibition of STING Ubiquitination.	TRIM32 TRIM56 RNF26	2.90e-07	6	86	3	35281267
Pubmed	Association of sweet taste receptor gene polymorphisms with dental caries experience in school children.	TAS1R3 TAS1R2	6.04e-06	2	86	2	25924601
Pubmed	Claudin-1 and Claudin-3 as Molecular Regulators of Myelination in Leukoaraiosis Patients.	CLDN3 CLDN1	6.04e-06	2	86	2	34008771
Pubmed	Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor.	TAS1R3 TAS1R2	6.04e-06	2	86	2	20302879
Pubmed	The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI.	TAS1R3 TAS1R2	6.04e-06	2	86	2	12706725
Pubmed	Sweet taste receptor deficient mice have decreased adiposity and increased bone mass.	TAS1R3 TAS1R2	6.04e-06	2	86	2	24466105
Pubmed	Interactions between the human sweet-sensing T1R2-T1R3 receptor and sweeteners detected by saturation transfer difference NMR spectroscopy.	TAS1R3 TAS1R2	6.04e-06	2	86	2	19664591
Pubmed	Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma.	NEGR1 MYEOV	6.04e-06	2	86	2	21624008
Pubmed	T1R2+T1R3-independent chemosensory inputs contributing to behavioral discrimination of sugars in mice.	TAS1R3 TAS1R2	6.04e-06	2	86	2	30624973
Pubmed	The importance of the presence of a 5'-ribonucleotide and the contribution of the T1R1 + T1R3 heterodimer and an additional low-affinity receptor in the taste detection of L-glutamate as assessed psychophysically.	TAS1R3 TAS1R2	6.04e-06	2	86	2	25253867
Pubmed	Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits.	TAS1R3 TAS1R2	6.04e-06	2	86	2	30723160
Pubmed	The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.	TAS1R3 TAS1R2	6.04e-06	2	86	2	17935609
Pubmed	T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to Polycose: implications for saccharide taste receptors in mice.	TAS1R3 TAS1R2	6.04e-06	2	86	2	19158407
Pubmed	A TAS1R receptor-based explanation of sweet 'water-taste'.	TAS1R3 TAS1R2	6.04e-06	2	86	2	16633339
Pubmed	Detection of maltodextrin and its discrimination from sucrose are independent of the T1R2 + T1R3 heterodimer.	TAS1R3 TAS1R2	6.04e-06	2	86	2	28768658
Pubmed	Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.	TAS1R3 TAS1R2	6.04e-06	2	86	2	31553164
Pubmed	Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity.	TAS1R3 TAS1R2	6.04e-06	2	86	2	26884387
Pubmed	Distinct human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3.	TAS1R3 TAS1R2	6.04e-06	2	86	2	25029362
Pubmed	Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation.	CLDN3 CLDN1	6.04e-06	2	86	2	28493289
Pubmed	Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal.	TAS1R3 TAS1R2	6.04e-06	2	86	2	22621968
Pubmed	Micro and macro models of the sweet receptor.	TAS1R3 TAS1R2	6.04e-06	2	86	2	15738209
Pubmed	LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth.	LITAF TNFSF15	6.04e-06	2	86	2	21217782
Pubmed	Double mutation of claudin-1 and claudin-3 causes alopecia in infant mice.	CLDN3 CLDN1	6.04e-06	2	86	2	37002535
Pubmed	Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3.	TAS1R3 TAS1R2	6.04e-06	2	86	2	37938171
Pubmed	Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.	TAS1R3 TAS1R2	6.04e-06	2	86	2	26157055
Pubmed	Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3.	CLDN3 CLDN1	6.04e-06	2	86	2	25849148
Pubmed	Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.	TAS1R3 TAS1R2	6.04e-06	2	86	2	28228527
Pubmed	Behavioral evidence for a glucose polymer taste receptor that is independent of the T1R2+3 heterodimer in a mouse model.	TAS1R3 TAS1R2	6.04e-06	2	86	2	21940444
Pubmed	Salivary leptin and TAS1R2/TAS1R3 polymorphisms are related to sweet taste sensitivity and carbohydrate intake from a buffet meal in healthy young adults.	TAS1R3 TAS1R2	6.04e-06	2	86	2	29110749
Pubmed	Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.	TAS1R3 TAS1R2	6.04e-06	2	86	2	32607758
Pubmed	Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.	TAS1R3 TAS1R2	6.04e-06	2	86	2	32551626
Pubmed	Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides.	TAS1R3 TAS1R2	6.04e-06	2	86	2	27162343
Pubmed	The anatomy of mammalian sweet taste receptors.	TAS1R3 TAS1R2	6.04e-06	2	86	2	27936499
Pubmed	The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.	TAS1R3 TAS1R2	6.04e-06	2	86	2	21540445
Pubmed	Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli.	TAS1R3 TAS1R2	6.04e-06	2	86	2	16271873
Pubmed	Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption.	TAS1R3 TAS1R2	6.04e-06	2	86	2	29019082
Pubmed	Claudin immunolocalization in neonatal mouse epithelial tissues.	CLDN3 CLDN1	6.04e-06	2	86	2	17828607
Pubmed	Neural Isolation of the Olfactory Bulbs Severely Impairs Taste-Guided Behavior to Normally Preferred, But Not Avoided, Stimuli.	TAS1R3 TAS1R2	6.04e-06	2	86	2	32152061
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCSK5 ADAMTS7 INTS1 NINL PIGW CLDN3 JADE1 TEP1 ABCA7 CDPF1 MED12 ANO8	1.75e-05	1105	86	12	35748872
Pubmed	Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity.	TAS1R3 TAS1R2	1.81e-05	3	86	2	28361903
Pubmed	An amino-acid taste receptor.	TAS1R3 TAS1R2	1.81e-05	3	86	2	11894099
Pubmed	Mammalian sweet taste receptors.	TAS1R3 TAS1R2	1.81e-05	3	86	2	11509186
Pubmed	The downregulation of sweet taste receptor signaling in enteroendocrine L-cells mediates 3-deoxyglucosone-induced attenuation of high glucose-stimulated GLP-1 secretion.	TAS1R3 TAS1R2	1.81e-05	3	86	2	29277113
Pubmed	The receptors for mammalian sweet and umami taste.	TAS1R3 TAS1R2	1.81e-05	3	86	2	14636554
Pubmed	The expression patterns of tight junction protein claudin-1, -3, and -4 in human gastric neoplasms and adjacent non-neoplastic tissues.	CLDN3 CLDN1	1.81e-05	3	86	2	25755790
Pubmed	Three sweet receptor genes are clustered in human chromosome 1.	TAS1R3 TAS1R2	1.81e-05	3	86	2	12856281
Pubmed	Molecular genetic identification of a candidate receptor gene for sweet taste.	TAS1R3 TAS1R2	1.81e-05	3	86	2	11322794
Pubmed	Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media.	CLDN3 CLDN1	1.81e-05	3	86	2	18817843
Pubmed	Role of claudin interactions in airway tight junctional permeability.	CLDN3 CLDN1	1.81e-05	3	86	2	12909588
Pubmed	Amino acid taste receptor regulates insulin secretion in pancreatic β-cell line MIN6 cells.	TAS1R3 TAS1R2	1.81e-05	3	86	2	21470345
Pubmed	Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.	TAS1R3 TAS1R2	1.81e-05	3	86	2	29443544
Pubmed	Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation.	CLDN3 CLDN1	1.81e-05	3	86	2	28415153
Pubmed	Claudins upregulation in human colorectal cancer.	CLDN3 CLDN1	1.81e-05	3	86	2	16253248
Pubmed	Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.	TAS1R3 TAS1R2	1.81e-05	3	86	2	12892531
Pubmed	Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.	TAS1R3 TAS1R2	1.81e-05	3	86	2	24068707
Pubmed	Manner of interaction of heterogeneous claudin species within and between tight junction strands.	CLDN3 CLDN1	1.81e-05	3	86	2	10562289
Pubmed	Increased permeability of the epithelium of middle ear cholesteatoma.	CLDN3 CLDN1	1.81e-05	3	86	2	25319490
Pubmed	Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.	TAS1R3 TAS1R2	1.81e-05	3	86	2	33654187
Pubmed	REEP2 enhances sweet receptor function by recruitment to lipid rafts.	TAS1R3 TAS1R2	1.81e-05	3	86	2	20943918
Pubmed	All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4.	CLDN3 CLDN1	1.81e-05	3	86	2	31044387
Pubmed	Phosphorus Taste Involves T1R2 and T1R3.	TAS1R3 TAS1R2	1.81e-05	3	86	2	28383662
Pubmed	Taste information derived from T1R-expressing taste cells in mice.	TAS1R3 TAS1R2	1.81e-05	3	86	2	26912569
Pubmed	Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study.	CLDN3 CLDN1	1.81e-05	3	86	2	15743508
Pubmed	Identification of claudin‑1, ‑3, ‑7 and ‑8 as prognostic markers in human laryngeal carcinoma.	CLDN3 CLDN1	3.61e-05	4	86	2	31115553
Pubmed	Human receptors for sweet and umami taste.	TAS1R3 TAS1R2	3.61e-05	4	86	2	11917125
Pubmed	Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion.	TAS1R3 TAS1R2	3.61e-05	4	86	2	20876097
Pubmed	Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme.	CLDN3 CLDN1	3.61e-05	4	86	2	12734665
Pubmed	Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and beta-catenin.	CLDN3 CLDN1	3.61e-05	4	86	2	19184060
Pubmed	The receptors and cells for mammalian taste.	TAS1R3 TAS1R2	3.61e-05	4	86	2	17108952
Pubmed	Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases.	CLDN3 CLDN1	3.61e-05	4	86	2	11382769
Pubmed	Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions.	CLDN3 CLDN1	3.61e-05	4	86	2	10508613
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	SSPN METRN DBNDD2 SLC39A4 SVOP ABCA7 CDPF1 ANO8 TSPAN33	5.77e-05	697	86	9	28298427
Pubmed	Expression of occludin and claudins 1, 3, 4, and 7 in urothelial carcinoma of the upper urinary tract.	CLDN3 CLDN1	6.01e-05	5	86	2	18550469
Pubmed	Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung.	CLDN3 CLDN1	6.01e-05	5	86	2	20478039
Pubmed	Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin.	TAS1R3 TAS1R2	6.01e-05	5	86	2	18174025
Pubmed	Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.	TAS1R3 TAS1R2	6.01e-05	5	86	2	22315413
Pubmed	Differential expression of claudin family proteins in mouse ovarian serous papillary epithelial adenoma in aging FSH receptor-deficient mutants.	CLDN3 CLDN1	6.01e-05	5	86	2	17217615
Pubmed	Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.	CLDN3 CLDN1	6.01e-05	5	86	2	15070779
Pubmed	Generation and characterization of T1R2-LacZ knock-in mouse.	TAS1R3 TAS1R2	6.01e-05	5	86	2	20965149
Pubmed	Distinct claudin expression profile in histologic subtypes of lung cancer.	CLDN3 CLDN1	6.01e-05	5	86	2	17418912
Pubmed	A candidate taste receptor gene near a sweet taste locus.	TAS1R3 TAS1R2	9.01e-05	6	86	2	11319557
Pubmed	HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study.	CLDN3 CLDN1	1.26e-04	7	86	2	18538010
Pubmed	Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury.	MFGE8 GPR37L1	1.68e-04	8	86	2	27881777
Pubmed	Claudins in human cancer: a review.	CLDN3 CLDN1	1.68e-04	8	86	2	19924644
Pubmed	Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.	CLDN3 CLDN1	1.68e-04	8	86	2	9892664
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	NEGR1 SLC47A1 SVOP CLDN1 SLC6A14	1.87e-04	212	86	5	19521566
Pubmed	HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy.	CLDN3 CLDN1	2.15e-04	9	86	2	24840331
Pubmed	Expression patterns of claudins, tight junction adhesion molecules, in the inner ear.	CLDN3 CLDN1	2.15e-04	9	86	2	14698084
Pubmed	The gut-brain axis mediates sugar preference.	TAS1R3 TAS1R2	2.15e-04	9	86	2	32322067
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	UBE4A TRIM32 TRIM56 RNF26	2.16e-04	118	86	4	19690564
Pubmed	The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.	TAS1R3 TAS1R2	2.68e-04	10	86	2	17156446
Pubmed	Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys.	CLDN3 CLDN1	2.68e-04	10	86	2	16520537
Pubmed	claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.	CLDN3 CLDN1	2.68e-04	10	86	2	11585919
Pubmed	Tight junction proteins at the blood-brain barrier: far more than claudin-5.	CLDN3 CLDN1	2.68e-04	10	86	2	30734065
Pubmed	Members of RTP and REEP gene families influence functional bitter taste receptor expression.	TAS1R3 TAS1R2	2.68e-04	10	86	2	16720576
Pubmed	Permeability barrier dysfunction in transgenic mice overexpressing claudin 6.	CLDN3 CLDN1	2.68e-04	10	86	2	11923212
Pubmed	The temporal and spatial expression of Claudins in epidermal development and the accelerated program of epidermal differentiation in K14-CaSR transgenic mice.	CLDN3 CLDN1	3.28e-04	11	86	2	17182288
Pubmed	Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma.	UBE4A TRIM56	3.28e-04	11	86	2	28963376
Pubmed	Expression of claudins in murine tooth development.	CLDN3 CLDN1	3.28e-04	11	86	2	17075866
Pubmed	Bone morphogenetic protein (BMP) 7 expression is regulated by the E3 ligase UBE4A in diabetic nephropathy.	UBE4A TRIM56	3.28e-04	11	86	2	30663414
GeneFamily	Taste 1 receptors	TAS1R3 TAS1R2	2.92e-05	3	57	2	1161
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPR26 SLC16A3 SLC39A4 F2R TNFSF15 CLDN1	7.92e-07	166	85	6	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	AT1-AT2_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	NKAIN4 GLDC GPR37L1 LAMC2 VWCE CLDN1	1.11e-06	176	85	6	f86832cfeff5b3cfffe4455c1b96a1420d48ba1e
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LITAF RNASET2 TNFSF15 CLDN1 TSPAN33 STAB1	1.35e-06	182	85	6	16186b7a0c33caa48631962381e3ab7e5d166163
ToppCell	facs-Trachea-nan-24m-Epithelial-mucus_secreting_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GGH GPR37L1 LAMC2 CLDN3 SLC6A14 TSPAN33	1.49e-06	185	85	6	e502ec54971f518d0cf1b619b745607a8ab5ddf3
ToppCell	E17.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DLK2 LAMC2 SLC39A4 CLDN3 TNFSF15 SLC6A14	1.74e-06	190	85	6	15f314517ed47b12d287a12a7d18cb383310e25a
ToppCell	distal-2-Hematologic-Natural_Killer_T\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UTS2 LITAF TMC8 P2RY8 OMG S1PR4	2.27e-06	199	85	6	f89165dab4a75ef5d93bf0f047fc61099442db35
ToppCell	distal-Hematologic-Natural_Killer_T-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UTS2 LITAF TMC8 P2RY8 OMG S1PR4	2.27e-06	199	85	6	cf9c5b2a7d2b53d06d2f8edd1b2d12b6719ebfef
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PCSK5 MFGE8 CNNM2 NEGR1 ADAM22 CLDN1	2.34e-06	200	85	6	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADAMTS7 NEGR1 GLDC CYB561D1 SLC47A1	1.39e-05	160	85	5	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SNED1 METRN CYB561D1 URB2 F2R	1.57e-05	164	85	5	583dda853cee9491dbdcb228c23d8deadc20eb08
ToppCell	normal_Pleural_Fluid-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	LAMC2 KDM8 BMPER ADAM22 SLC6A14	1.66e-05	166	85	5	d16af6570806ed2880bd0efb5298932fd2a89cf5
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GGH SLC39A4 CLDN3 SLC30A10 SLC6A14	1.92e-05	171	85	5	e7dbee63cc39230aa12e7868ec78a129160c0d22
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-Enterocyte\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GGH SLC39A4 CLDN3 SLC30A10 SLC6A14	1.92e-05	171	85	5	b0d616699e2110ffd6cf1868ed1f1a29f824e1fc
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNED1 GLDC SLC47A1 JADE1 BMPER	2.14e-05	175	85	5	b4f01e7782cdd107d0817ef601891fd3a382bc35
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNED1 GLDC SLC47A1 JADE1 BMPER	2.14e-05	175	85	5	ef6f811d8e1839f405c3b41090ddf79be57a099f
ToppCell	droplet-Fat-Bat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNED1 GLDC SLC47A1 JADE1 BMPER	2.14e-05	175	85	5	7f7598d46d10bff1cbea42f950bdde1aaa16e9a4
ToppCell	ICU-SEP-Myeloid-cDC2\|ICU-SEP / Disease, Lineage and Cell Type	SSPN CNNM2 NEGR1 PIGW SVOP	2.14e-05	175	85	5	c44fd1cc827296de7300d4a60399bb945089a170
ToppCell	droplet-Limb_Muscle-nan-21m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL3 NKAIN4 CYB561D1 GPR37L1 CLDN1	2.26e-05	177	85	5	291231b1520c135e92739e201495fe1935efa927
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	MSRB3 MFGE8 SSPN NKAIN4 ADAM22	2.52e-05	181	85	5	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLDC SLC47A1 CLDN3 VWCE CLDN1	2.59e-05	182	85	5	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLDC SLC47A1 CLDN3 VWCE CLDN1	2.59e-05	182	85	5	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLDC SLC47A1 CLDN3 VWCE CLDN1	2.59e-05	182	85	5	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-Bergmann_glial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL3 METRN NKAIN4 GPR37L1 TSPAN33	2.66e-05	183	85	5	25c96df8ea0c7bbedbb7699ee84ad6234d19cba8
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHH METRN NKAIN4 NEGR1 GPR37L1	2.66e-05	183	85	5	2cf36ad89584eb9f8b04de52a1b511b7f3527884
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHH METRN NKAIN4 NEGR1 GPR37L1	2.66e-05	183	85	5	98fee6838acfaee5e2e449ba088764ec06b8bc57
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MFGE8 LITAF SLC39A4 CLDN3 TMEM205	2.73e-05	184	85	5	978135173891c83470370a42b2801e09eb740320
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR37L1 LAMC2 CLDN3 SLC6A14 TSPAN33	2.73e-05	184	85	5	61caaa31975e05c9a6512079c791fed5a9e2d39f
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR37L1 LAMC2 CLDN3 SLC6A14 TSPAN33	2.73e-05	184	85	5	03da0f0f89f1ca5a3ccca1e22972f3129464e68e
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	AP4E1 CYB561D1 TEP1 CDPF1 ADAM22	2.73e-05	184	85	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MFGE8 LITAF SLC39A4 CLDN3 TMEM205	2.73e-05	184	85	5	f58922cf593f4b739f2713ef88a2ca3014f927e9
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR37L1 LAMC2 CLDN3 SLC6A14 TSPAN33	2.73e-05	184	85	5	9ed2a65a4ca0ebbbb89ace61027522f93369843d
ToppCell	Hippocampus-Macroglia\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GGH METRN GLDC GPR37L1 TMEM205	2.73e-05	184	85	5	a1d039ddf1e2a87b870f3ce6d139be56090349df
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL3 TRIM56 DYNC2I1 SLC39A4 HYDIN	2.73e-05	184	85	5	264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL3 TRIM56 DYNC2I1 SLC39A4 HYDIN	2.73e-05	184	85	5	d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL3 TRIM56 DYNC2I1 SLC39A4 HYDIN	2.73e-05	184	85	5	22010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHH METRN NKAIN4 GPR37L1 OMG	2.73e-05	184	85	5	9f8cd5ab5af6c35a1be25d70a125b9a3f4dd667a
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHH NEGR1 TAS1R3 DBNDD2 GPR37L1	2.87e-05	186	85	5	adba5647a2feaba8e361dc1020d2f2dc4ce36b16
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RDH8 MFGE8 CNNM2 DBNDD2 BMPER	2.87e-05	186	85	5	6568358812f0ca4e0161a1a1b29682fbced35c79
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	METRN NKAIN4 NEGR1 DBNDD2 GPR37L1	2.87e-05	186	85	5	d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GGH MFGE8 OXA1L SLC6A14 TSPAN33	3.02e-05	188	85	5	5b69de5baaac45a6d4daa1dbfcb70a7b2ae744ac
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MSRB3 PCSK5 CNNM2 NEGR1 ADAM22	3.10e-05	189	85	5	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	3'_v3-bone_marrow-Lymphocytic_B_plasma\|bone_marrow / Manually curated celltypes from each tissue	GGH SSPN GLDC TAS1R3 MYEOV	3.10e-05	189	85	5	dceb011216deb4ffd830144a53c635c05dff5ec5
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	METRN NKAIN4 NEGR1 DBNDD2 GPR37L1	3.18e-05	190	85	5	ff3dec5b45c6ea9b5319fb51a0198c6773b7be26
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	SNED1 MFGE8 NEGR1 LAMC2 BMPER	3.18e-05	190	85	5	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	METRN NKAIN4 NEGR1 DBNDD2 GPR37L1	3.18e-05	190	85	5	4971857eac9af17d66d673ed2ab7072639f60a10
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MFGE8 NKAIN4 GLDC GPR37L1 SLC30A10	3.26e-05	191	85	5	fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MSRB3 PCSK5 CNNM2 NEGR1 ADAM22	3.34e-05	192	85	5	992d08092edbc68c47b945deb8708379738c239a
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	DHH ADAMTS7 BMPER F2R STAB1	3.42e-05	193	85	5	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	DHH ADAMTS7 BMPER F2R STAB1	3.42e-05	193	85	5	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MSRB3 MFGE8 SSPN CNNM2 DBNDD2	3.42e-05	193	85	5	360079cbaa18b74e4a48c5de40844faca076e1a6
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MFGE8 DBNDD2 CLDN3 CLDN1 TSPAN33	3.51e-05	194	85	5	550e61a40be2baa59520aaf5912bb99ad094ba15
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MFGE8 NKAIN4 BMPER F2R CLDN1	3.60e-05	195	85	5	4a5d2f62aad5817d077177bf8b4ff0e46d3b8d97
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_Central_Memory_T_cells\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SNED1 SLC16A3 LITAF RNASET2 S1PR4	3.60e-05	195	85	5	0a200e43e861d5a24c07244c576bba5d67efcf2d
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MFGE8 NKAIN4 BMPER F2R CLDN1	3.60e-05	195	85	5	7a32a8535c29b819dacba901d0658280a2631c94
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SSPN RPP21 TMC8 P2RY8 TSPAN33	3.78e-05	197	85	5	ccabb976b5d4800e87e550640454a893fdb3b1b6
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMC2 SLC39A4 CLDN3 F2R SLC6A14	3.78e-05	197	85	5	b0fb5774525ba05f60c635d42f14bb8d79bff17c
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMC2 SLC39A4 CLDN3 F2R SLC6A14	3.78e-05	197	85	5	bbb7c106d5b96b8e95aeb3e5c293e104fceea234
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RPP21 TAS1R3 TMC8 P2RY8 TSPAN33	3.78e-05	197	85	5	e4b4fa219322b3250b482f8e242f41e8b05485db
ToppCell	(0)_NK_cells-(0)_NK_FCGR3Apos\|(0)_NK_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PCSK5 LITAF P2RY8 F2R S1PR4	3.87e-05	198	85	5	eba39656c6f699ab297b652ded8cb9727b49593c
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD3-NKT\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LITAF TMC8 P2RY8 F2R S1PR4	4.06e-05	200	85	5	846d3f0e647040d0e372df0dfcd69a21d5da5aea
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	METRN NKAIN4 LITAF GPR37L1 OMG	4.06e-05	200	85	5	439265194cb08d1373296bf8684cc31294cecb20
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Macroglial-Astrocyte\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	MFGE8 NKAIN4 LITAF GPR37L1 OMG	4.06e-05	200	85	5	158ba898312c73bcb54c675a4860874a1dd58662
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MSRB3 SNED1 MFGE8 NEGR1 BMPER	4.06e-05	200	85	5	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD3\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LITAF TMC8 P2RY8 F2R S1PR4	4.06e-05	200	85	5	c70f06b243ae9804f97308ee02b4b5e1a4a6f9f3
ToppCell	distal-2-Epithelial\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LAMC2 CLDN3 HYDIN CLDN1 SLC6A14	4.06e-05	200	85	5	2fc1e95706f212bf18ecdf6eb5b3182ac98c9b52
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PCSK5 SSPN NEGR1 ADAM22 CLDN1	4.06e-05	200	85	5	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MSRB3 SNED1 MFGE8 NEGR1 BMPER	4.06e-05	200	85	5	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	Biopsy_IPF-Epithelial-KRT5-/KRT17+\|Biopsy_IPF / Sample group, Lineage and Cell type	MFGE8 NKAIN4 SLC47A1 LAMC2 CLDN1	4.06e-05	200	85	5	2fc7a3b3aea711ad3d96fd9513f4b40533056d86
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Macroglial\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	MFGE8 NKAIN4 LITAF GPR37L1 OMG	4.06e-05	200	85	5	46f99bed98da09e6d3f45d4443cbaa6b6c1589bb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Macroglial\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	MFGE8 METRN NKAIN4 LITAF GPR37L1	4.06e-05	200	85	5	70c2e577efb6b6fe8f9d970d7ecc470788efb85b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Macroglial-Astrocyte\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	MFGE8 METRN NKAIN4 LITAF GPR37L1	4.06e-05	200	85	5	4fe3b2d80c567c18621bff3341f9a73578c81621
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related-OPC\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	METRN NKAIN4 LITAF GPR37L1 OMG	4.06e-05	200	85	5	0450a79c5fae5ccacdb990ae674e4734ef0c3691
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC2\|ICU-SEP / Disease, condition lineage and cell class	SSPN CNNM2 NEGR1 PIGW SVOP	4.06e-05	200	85	5	09d5c3a3d2b42b15c769dc2bc14b6c0d5cc38f91
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Macroglial\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	MFGE8 METRN NKAIN4 LITAF OMG	4.06e-05	200	85	5	25b573f4427ecafe050ca90bea459f1b25b451cf
ToppCell	E18.5-samps-Epithelial-Alveolar_epithelial-Uncommitted_AE_Progenitor\|E18.5-samps / Age Group, Lineage, Cell class and subclass	VSIG10L CYB561D1 SLC39A4 CLDN3	9.08e-05	123	85	4	5f002f5180fe47fe57ab888b5f0319df99ab2c59
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Platelets-Platelets\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTCRA F2R TSPAN33 STAB1	1.03e-04	127	85	4	29d0b078b9fb151b2689263828a0a2f178196d16
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Platelets\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTCRA F2R TSPAN33 STAB1	1.03e-04	127	85	4	041fb924aa2138a86612e07a9a5759cbbe2446e0
ToppCell	droplet-Fat-Gat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEGR1 CYB561D1 DYNC2I1 KDM8	1.19e-04	132	85	4	4152529611eeacf0c547e2a134d5b98c45426b13
ToppCell	facs-Thymus-Epithelium-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GGH TRIM32 DYNC2I1 VWCE	1.19e-04	132	85	4	6f711fe84135406a8114a898a14c5ea0dfad74f2
ToppCell	PND01-Immune-Immune_Myeloid-DC-cDC2\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC16A3 TEP1 CLDN1 TSPAN33	2.05e-04	152	85	4	cefc0ab592e99badf145fb95adf9906cb81be81c
ToppCell	PND01-Immune-Immune_Myeloid-DC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC16A3 TEP1 CLDN1 TSPAN33	2.05e-04	152	85	4	c8faa83dcaddb2ce2bb890f90dd8e676f7dcb1b3
ToppCell	PND01-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC16A3 TEP1 CLDN1 TSPAN33	2.05e-04	152	85	4	c3f00beb8b6fde99263d5ed6bbe3c2415d02f91d
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|lymph-node_spleen / Manually curated celltypes from each tissue	KDM8 VWCE TEP1 ADAM22	2.21e-04	155	85	4	b0e456c4915076e1d38282e116a6eb3230ae80dc
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLDC SLC47A1 SLC30A10 CLDN1	2.26e-04	156	85	4	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4\|GI_large-bowel / Manually curated celltypes from each tissue	DBNDD2 TEP1 MED12 S1PR4	2.26e-04	156	85	4	01f2c0c6a936dfb59bc727feef428a906ad2a80b
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MFGE8 METRN GLDC GPR37L1	2.32e-04	157	85	4	0551442ae14685d8fe5729e3960c6324b1e05e4d
ToppCell	frontal_cortex-Non-neuronal-astrocyte\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MFGE8 METRN GLDC GPR37L1	2.32e-04	157	85	4	803af734d7f775d294391e2b84e472a732e18cef
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MFGE8 METRN GLDC GPR37L1	2.32e-04	157	85	4	9aa5304a9704da6dd4eda7d6940494b00e38b2e8
ToppCell	droplet-Lung-1m-Hematologic-myeloid-neutrophil-neutrophil\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GSDME SLC16A3 LITAF SLC39A4	2.43e-04	159	85	4	be54b910ccb73e37eb81945bbad9a89d2bcec34b
ToppCell	droplet-Lung-1m-Hematologic-myeloid-neutrophil\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GSDME SLC16A3 LITAF SLC39A4	2.43e-04	159	85	4	178678173b005cb8225472306657f0d8289b133b
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DBNDD2 TNFSF15 ADAM22 STAB1	2.49e-04	160	85	4	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Hpcal-Krt12_(Entorhinal_cortex)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	UTS2 TMC8 TNFSF15	2.49e-04	64	85	3	2c214aa905083eb8bd8e66d33643987280030eb8
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Hpcal-Krt12_(Entorhinal_cortex)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	UTS2 TMC8 TNFSF15	2.49e-04	64	85	3	813e9c3c10ebcee3638db843e19818bb37529895
ToppCell	VE-CD8-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	UTS2 P2RY8 URB2 ABCA7	2.55e-04	161	85	4	a114f4f75859d9ef900e5146686438d051241429
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYB561D1 NINL TEP1 TSPAN33	2.61e-04	162	85	4	388670cf3acef17df971c0d8ae3ce14398945192
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYB561D1 NINL TEP1 TSPAN33	2.61e-04	162	85	4	9333d923225df7bfdf6b3a4c32816751315aec50
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEGR1 DBNDD2 TEP1 ADAM22	2.74e-04	164	85	4	758e85e2f5e7236b345e16c78344d5e0bf17d8dc
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSPN GSDME DLK2 CLDN1	2.87e-04	166	85	4	1f39c7507ac6881aa1a30f8be22f98a1837d926b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC16A3 LITAF TMC8 STAB1	2.93e-04	167	85	4	1cd9e2af85c6c5b9e1d88991c87ac6980b387243
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GLDC LAMC2 CLDN3 S1PR4	2.93e-04	167	85	4	25af48c640e67848594f5902867ba325fc105da4
Drug	Levamisole hydrochloride [16595-80-5]; Up 200; 16.6uM; MCF7; HT_HG-U133A	DLK2 ACVR1B TEP1 F2R ABCA7 ADAM22 CLDN1	8.30e-06	199	83	7	7450_UP
Drug	1,6-dichlorosucrose	TAS1R3 TAS1R2	1.31e-05	2	83	2	ctd:C039464
Drug	1-chlorosucrose	TAS1R3 TAS1R2	1.31e-05	2	83	2	ctd:C039463
Drug	neotame	TAS1R3 TAS1R2	1.31e-05	2	83	2	ctd:C404525
Disease	lung adenocarcinoma	UBE4A ADAMTS7 RNASET2 ACVR1B	1.36e-03	174	81	4	EFO_0000571
Disease	cerebellum white matter volume change measurement, age at assessment	ADAMTS7 SLC30A10	1.37e-03	20	81	2	EFO_0008007, EFO_0021498
Disease	Kidney Diseases	PCSK5 CNNM2 SLC47A1	1.85e-03	88	81	3	C0022658
Disease	lung small cell carcinoma (is_implicated_in)	LAMC2 ACVR1B	2.69e-03	28	81	2	DOID:5409 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALTCCLVLLPFLAGL	TNFSF15	36	O95150
QLLCFQVLPRLFGCL	URB2	321	Q14146
TNLPLQSPCCRLCFL	LINC00310	41	P59036
QALCGLCLLCPRAAR	CYB561D1	141	Q8N8Q1
PRGVQALLCACTSCL	ACVR1B	26	P36896
LDLFCDCLGCNLIFP	GVINP1	2211	Q7Z2Y8
VFPLLLCITLNGLCA	GSDME	476	O60443
FLLLCVLGTCPPARC	ADAM22	11	Q9P0K1
LCSRLVCVGPECSLF	CDPF1	66	Q6NVV7
LPALCLCVLVLACIG	APOC4	11	P55056
LLGRCQLPTIRTQCC	ADAMTS7	1651	Q9UKP4
LCCCGSPLFLRRHLG	ABCA7	1016	Q8IZY2
QLLVSLPLCLACLVC	ANO8	356	Q9HCE9
ACQLLPSIPCLLHCR	AP4E1	1091	Q9UPM8
KLTLCLSCLNNCLDP	P2RY8	276	Q86VZ1
SLCLLGCIAGCCFIP	LITAF	121	Q99732
PQCCGNLLVLCLFLV	C22orf46	36	C9J442
LLFDLLLTCSCLCDP	PTCRA	161	Q6ISU1
TPGLCARLALACCLR	OR10AC1	141	Q8NH08
LLSLCCLLPSCLPAG	NEGR1	21	Q7Z3B1
CTLRFELLGCELNGC	MFGE8	216	Q08431
SLIQARLPLLLSCCC	INTS1	1756	Q8N201
AALLCALCCGLLAPA	METRN	6	Q9UJH8
CRCLDLLFLSQGGLC	ERVS71-1	506	P61550
LILGGLLLNCCVCAA	SLC16A3	181	O15427
AIGCLLKALCLCQAP	KDM8	96	Q8N371
CCCLSPLKAFLLFAG	DYNC2I1	701	Q8WVS4
APLLLLLCCCKQRQP	DSG4	646	Q86SJ6
PALFTLNLTCGNLLC	GPR26	41	Q8NDV2
LCVLALLGGCLLPVC	PCSK5	16	Q92824
PALPIGLCTRCCLCL	MYEOV	11	Q96EZ4
GLSCILQTILLCCPS	MED12	361	Q93074
LTTRLLFPVAPCCCR	OXA1L	36	Q15070
FRCPRLLNLGLQCLS	RDH8	286	Q9NYR8
LLNLGLQCLSCGCLP	RDH8	291	Q9NYR8
LLLVAACFSLCGPLL	F2R	6	P25116
LLRPLFLLSGCCQAL	HYDIN	4511	Q4G0P3
ITCCVLLLLNCSGVP	BMPER	21	Q8N8U9
LLGGALLCCSCPRKT	CLDN1	176	O95832
CLLCVLGLLLCGAAS	GGH	6	Q92820
GPLCLLFRLCSCTCF	DBNDD2	76	Q9BQY9
CCLALLALPAQSCGP	DHH	11	O43323
LLCICRPLGQAFLDC	GPR37L1	416	O60883
VSLLCRPICRPACCL	KRTAP10-5	221	P60370
LGCCLCFSLLLPAAR	LAMC2	6	Q13753
RCLHLVCLLCILGAP	DLK2	6	Q6UY11
CRACNLSLPFHGCLL	C9orf57	81	Q5W0N0
RAVLSFLCCGCLRLG	S1PR4	316	O95977
RCICCFLLGLLLAVT	PIP4P1	211	Q86T03
LLLLLCAVCRGCSAL	MIEF2	356	Q96C03
SCCLLFIGFLNPLLS	UTS2	6	O95399
RLPRQFCRSCGLVLC	TRIM32	106	Q13049
GCCLLAALASCFLPI	SVOP	496	Q8N4V2
LCNLGCVLSNGLCLA	TMEM205	166	Q6UW68
LICLCAVFGLLLLTC	SLC39A4	336	Q6P5W5
LLLPCRHLCLCQACT	RNF26	391	Q9BY78
LCRGCSSLLVPGLTC	RPP21	61	Q9H633
LRPARLPLNCCVFCK	SHPRH	1231	Q149N8
TCCGCRFPLLLALLQ	SSPN	46	Q14714
LCRTCALGVQPKCLL	JADE1	246	Q6IE81
TLPRPLSLCLSLCLC	MSRB3	6	Q8IXL7
LAPCCTQALCGLALR	NINL	711	Q9Y2I6
PACCALLLVLGLCRA	SGSH	6	P51688
LFLTPGILCICPLQC	OMG	16	P23515
GILCICPLQCICTER	OMG	21	P23515
LQRSALVLLLCCFPC	SLC47A1	116	Q96FL8
LCFPAFCILCRGFLI	PIGW	26	Q7Z7B1
VCLALRPCLNGGKCI	SNED1	271	Q8TER0
TLCQCPLGFFGLLCE	SNED1	486	Q8TER0
ALQLLGGALLCCSCP	CLDN3	171	O15551
GRLLPLLLLSCCCGA	CNNM2	46	Q9H8M5
CLQILIALLGFVCGC	NKAIN4	151	Q8IVV8
LRGALLGCLCLALLC	RNASET2	6	O00584
CGCIGSLRENICLLQ	TSPAN33	81	Q86UF1
LLLLCNSPCISKGCA	SLC30A10	396	Q6XR72
LACFGLVCLGLVCLS	TAS1R3	606	Q7RTX0
LLSPLACLLLCFCGT	TMC8	206	Q8IU68
QITGCCLSPDCRLLA	TEP1	1761	Q99973
CLSPDCRLLATVCLG	TEP1	1766	Q99973
LDPCLSCICLLGSVA	VWCE	646	Q96DN2
QPCCCLRLLGLTGLL	SIRPD	181	Q9H106
GLLPLCLLAFCLAGF	STAB1	6	Q9NY15
LCLRGPQLEVPCCLC	TTLL3	646	Q9Y4R7
LPCTNFHLLLCCAIL	TBC1D15	556	Q8TC07
LCRQALFPLCFTICI	TAS1R2	631	Q8TE23
SLLCGCSLVLSCLCP	FP248	6	Q71RG6
LCCVVFCLLQAGPLD	TRBV3-1	6	A0A576
LNLGAALLKLCQPFC	UBE4A	436	Q14139
LLCICCLCRFRGKTP	VSIG10L	796	Q86VR7
TLGCCLVLFLLGLVC	SLC6A14	451	Q9UN76
ALRFLCQPCSQLLCR	TRIM56	176	Q9BRZ2
CCATDLLALCILRPP	GLDC	291	P23378