Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coregulator binding

NEK6 FOXP2 CTCF ZNF644 FOXP1 CIT

1.23e-05140736GO:0001221
GeneOntologyMolecularFunctionchromatin insulator sequence binding

ZNF276 CTCF

2.74e-047732GO:0043035
GeneOntologyMolecularFunctionDEAD/H-box RNA helicase binding

AKAP8L ZC3HAV1

4.67e-049732GO:0017151
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

OVOL1 DPRX FOXP2 CTCF GLI2 ZNF652 ZNF644 SP6 ZFHX2 MECOM FOXP1 PRDM15 ZNF646

5.20e-0412447313GO:0000978
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

RLF OVOL1 DPRX FOXP2 CTCF GLI2 ZNF652 ZNF644 SP6 ZFHX2 MECOM FOXP1 PRDM15 ZNF646

5.23e-0414127314GO:0000981
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

OVOL1 DPRX FOXP2 CTCF GLI2 ZNF652 ZNF644 SP6 ZFHX2 MECOM FOXP1 PRDM15 ZNF646

6.37e-0412717313GO:0000987
GeneOntologyBiologicalProcessinnate vocalization behavior

FOXP2 FOXP1

3.60e-053722GO:0098582
GeneOntologyBiologicalProcessestrogen catabolic process

UGT1A8 UGT1A9

1.19e-045722GO:0006711
GeneOntologyBiologicalProcessflavonoid glucuronidation

UGT1A8 UGT1A9

1.19e-045722GO:0052696
GeneOntologyBiologicalProcessmRNA export from nucleus

FMR1 NUP88 YTHDC1 AKAP8L

1.31e-0474724GO:0006406
GeneOntologyBiologicalProcessmRNA transport

FMR1 NUP210 NUP88 YTHDC1 AKAP8L

1.54e-04145725GO:0051028
GeneOntologyBiologicalProcessfilopodium assembly

FMR1 FGD1 PRKCQ FNBP1L

1.60e-0478724GO:0046847
GeneOntologyBiologicalProcessphenylpropanoid catabolic process

UGT1A8 UGT1A9

1.79e-046722GO:0046271
GeneOntologyBiologicalProcesscoumarin catabolic process

UGT1A8 UGT1A9

1.79e-046722GO:0046226
GeneOntologyBiologicalProcessflavone metabolic process

UGT1A8 UGT1A9

1.79e-046722GO:0051552
GeneOntologyBiologicalProcessnucleobase-containing compound transport

FMR1 NUP210 NUP88 ABCC11 YTHDC1 AKAP8L

2.34e-04249726GO:0015931
GeneOntologyBiologicalProcesspositive regulation of filopodium assembly

FMR1 PRKCQ FNBP1L

2.68e-0436723GO:0051491
GeneOntologyBiologicalProcessregulation of chromosome organization

PBRM1 NEK6 MCPH1 CTCF PRKCQ CIT

3.33e-04266726GO:0033044
GeneOntologyBiologicalProcessnuclear transport

FMR1 NUP210 NUP88 PRKCQ YTHDC1 AKAP8L PPM1A

3.48e-04378727GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

FMR1 NUP210 NUP88 PRKCQ YTHDC1 AKAP8L PPM1A

3.48e-04378727GO:0006913
GeneOntologyBiologicalProcessRNA export from nucleus

FMR1 NUP88 YTHDC1 AKAP8L

3.56e-0496724GO:0006405
GeneOntologyBiologicalProcessRNA transport

FMR1 NUP210 NUP88 YTHDC1 AKAP8L

3.67e-04175725GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

FMR1 NUP210 NUP88 YTHDC1 AKAP8L

3.67e-04175725GO:0050657
GeneOntologyBiologicalProcessestablishment of RNA localization

FMR1 NUP210 NUP88 YTHDC1 AKAP8L

3.97e-04178725GO:0051236
GeneOntologyBiologicalProcessnuclear export

FMR1 NUP88 YTHDC1 AKAP8L PPM1A

4.73e-04185725GO:0051168
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

UGT1A8 UGT1A9

5.31e-0410722GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

UGT1A8 UGT1A9

5.31e-0410722GO:0009804
HumanPhenoProminent fingertip pads

GJA5 FOXP2 CTCF FOXP1

3.78e-0546224HP:0001212
HumanPhenoProminent digit pad

GJA5 FOXP2 CTCF FOXP1

4.48e-0548224HP:0011298
DomainZnf_C2H2-like

RLF ZXDC PRDM10 ZNF276 OVOL1 FOXP2 CTCF GLI2 ZNF652 ZNF644 SCAPER SP6 ZFHX2 ZNF511 MECOM FOXP1 PRDM15 AKAP8L ZNF646

1.35e-107967319IPR015880
DomainZnf_C2H2

RLF ZXDC PRDM10 ZNF276 OVOL1 FOXP2 CTCF GLI2 ZNF652 ZNF644 SCAPER SP6 ZFHX2 ZNF511 MECOM FOXP1 PRDM15 AKAP8L ZNF646

1.63e-108057319IPR007087
DomainZnF_C2H2

RLF ZXDC PRDM10 ZNF276 OVOL1 FOXP2 CTCF GLI2 ZNF652 ZNF644 SCAPER SP6 ZFHX2 ZNF511 MECOM FOXP1 PRDM15 AKAP8L ZNF646

1.73e-108087319SM00355
DomainZINC_FINGER_C2H2_2

RLF ZXDC PRDM10 ZNF276 OVOL1 FOXP2 CTCF GLI2 ZNF652 ZNF644 SCAPER SP6 ZFHX2 ZNF511 MECOM FOXP1 PRDM15 ZNF646

7.03e-107757318PS50157
DomainZINC_FINGER_C2H2_1

RLF ZXDC PRDM10 ZNF276 OVOL1 FOXP2 CTCF GLI2 ZNF652 ZNF644 SCAPER SP6 ZFHX2 ZNF511 MECOM FOXP1 PRDM15 ZNF646

7.33e-107777318PS00028
Domain-

RLF ZXDC PRDM10 ZNF276 OVOL1 CTCF GLI2 ZNF652 ZNF644 SP6 ZFHX2 ZNF511 MECOM PRDM15 ZNF646

4.51e-0867973153.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

RLF ZXDC PRDM10 ZNF276 OVOL1 CTCF GLI2 ZNF652 ZNF644 SP6 ZFHX2 ZNF511 MECOM PRDM15 ZNF646

6.00e-086947315IPR013087
Domainzf-C2H2

RLF PRDM10 ZNF276 OVOL1 CTCF GLI2 ZNF652 ZNF644 SP6 ZFHX2 ZNF511 MECOM PRDM15 ZNF646

4.00e-076937314PF00096
DomainC1_1

RAF1 DGKG PRKCI PRKCQ CIT

2.84e-0657735PF00130
DomainZF_DAG_PE_1

RAF1 DGKG PRKCI PRKCQ CIT

5.06e-0664735PS00479
DomainZF_DAG_PE_2

RAF1 DGKG PRKCI PRKCQ CIT

5.06e-0664735PS50081
DomainC1

RAF1 DGKG PRKCI PRKCQ CIT

5.46e-0665735SM00109
DomainPE/DAG-bd

RAF1 DGKG PRKCI PRKCQ CIT

5.89e-0666735IPR002219
DomainGPCR_2_brain_angio_inhib

ADGRB1 ADGRB3

4.51e-053732IPR008077
DomainDAG/PE-bd

RAF1 PRKCI PRKCQ

7.24e-0521733IPR020454
DomainFOXP-CC

FOXP2 FOXP1

9.00e-054732PF16159
DomainFOXP-CC

FOXP2 FOXP1

9.00e-054732IPR032354
DomainPkinase_C

PRKCI PRKCQ CIT

4.05e-0437733IPR017892
DomainEPL1

JADE3 BRD1

4.16e-048732PF10513
DomainEnhancer_polycomb-like_N

JADE3 BRD1

4.16e-048732IPR019542
DomainPkinase_C

PRKCI PRKCQ CIT

5.89e-0442733PF00433
DomainGAIN_dom_N

ADGRB1 ADGRB3

8.10e-0411732IPR032471
DomainGAIN

ADGRB1 ADGRB3

8.10e-0411732PF16489
DomainSET_dom

PRDM10 SMYD1 PRDM15

9.84e-0450733IPR001214
DomainSET

PRDM10 SMYD1 PRDM15

9.84e-0450733PS50280
DomainAGC-kinase_C

PRKCI PRKCQ CIT

1.37e-0356733IPR000961
DomainAGC_KINASE_CTER

PRKCI PRKCQ CIT

1.37e-0356733PS51285
DomainS_TK_X

PRKCI PRKCQ CIT

1.37e-0356733SM00133
DomainPP2C

PPM1A PHLPP2

2.47e-0319732PF00481
DomainPP2Cc

PPM1A PHLPP2

2.74e-0320732SM00332
DomainPPM-type_phosphatase_dom

PPM1A PHLPP2

2.74e-0320732IPR001932
Domain-

PPM1A PHLPP2

2.74e-03207323.60.40.10
DomainPPM_2

PPM1A PHLPP2

2.74e-0320732PS51746
DomainUDPGT

UGT1A8 UGT1A9

3.02e-0321732PF00201
DomainUDPGT

UGT1A8 UGT1A9

3.02e-0321732PS00375
DomainUDP_glucos_trans

UGT1A8 UGT1A9

3.02e-0321732IPR002213
DomainEPHD

JADE3 BRD1

3.31e-0322732PS51805
DomainHormR

ADGRB1 ADGRB3

4.26e-0325732SM00008
DomainBromodomain_CS

PBRM1 BRD1

4.61e-0326732IPR018359
DomainHRM

ADGRB1 ADGRB3

5.33e-0328732PF02793
DomainZnF_U1

SCAPER ZFHX2

5.71e-0329732SM00451
DomainZnf_U1

SCAPER ZFHX2

5.71e-0329732IPR003604
DomainGPS

ADGRB1 ADGRB3

7.80e-0334732SM00303
DomainGPS

ADGRB1 ADGRB3

8.25e-0335732PF01825
DomainGPS

ADGRB1 ADGRB3

8.71e-0336732PS50221
Pubmed

Human transcription factor protein interaction networks.

RLF PBRM1 NOP14 FOXP2 CTCF GLI2 ZNF644 SYNE2 NUP88 MRPL10 MECOM FOXP1 CIT DDX27 AKAP8L ZC3HAV1

3.50e-081429731635140242
Pubmed

Interaction network of human early embryonic transcription factors.

RLF PBRM1 DPRX FOXP2 ZNF644 NUP88 MECOM FOXP1 AKAP8L

5.39e-0835173938297188
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

PBRM1 NOP14 FMR1 CTCF NUP210 FOXP1 GEMIN6 YTHDC1 DDX27 AKAP8L GTF3C4 ZC3HAV1

1.90e-07847731235850772
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RLF RAF1 CASP8AP2 ZNF644 NUP88 MECOM FOXP1 AKAP8L GTF3C4

2.36e-0741873934709266
Pubmed

Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.

GUSB UGT1A8 UGT1A9

4.93e-07873312695355
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

PBRM1 FMR1 CTCF NUP88 BRD1 YTHDC1 DDX27 ZC3HAV1

4.97e-0733273825693804
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CASP8AP2 ZNF276 PBRM1 FMR1 MCPH1 JADE3 CTCF ZNF644 NUP88 MECOM YTHDC1 GTF3C4 ZC3HAV1

2.67e-061294731330804502
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

RAF1 PBRM1 FMR1 FOXP2 CTCF SCAPER MECOM FOXP1 BRD1 AKAP8L WDTC1 ZNF646

3.40e-061116731231753913
Pubmed

A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility.

ADGRB3 MECOM PRKCI

3.96e-061573314996723
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

PBRM1 FMR1 NUP210 NUP88 DDX27 AKAP8L GTF3C4 ZC3HAV1

4.03e-0644073834244565
Pubmed

Differential and Overlapping Pattern of Foxp1 and Foxp2 Expression in the Striatum of Adult Mouse Brain.

FOXP2 FOXP1

4.35e-06273230031127
Pubmed

The RNA Binding Proteins YTHDC1 and FMRP Regulate the Nuclear Export of N6-Methyladenosine-Modified Hepatitis B Virus Transcripts and Affect the Viral Life Cycle.

FMR1 YTHDC1

4.35e-06273233883220
Pubmed

Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion.

FOXP2 FOXP1

4.35e-06273230104377
Pubmed

Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.

UGT1A8 UGT1A9

4.35e-06273218568343
Pubmed

Investigating protein-protein interactions in live cells using bioluminescence resonance energy transfer.

FOXP2 FOXP1

4.35e-06273224893771
Pubmed

Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction.

FOXP2 FOXP1

4.35e-06273215056695
Pubmed

A de novo FOXP1 variant in a patient with autism, intellectual disability and severe speech and language impairment.

FOXP2 FOXP1

4.35e-06273225853299
Pubmed

FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures.

FOXP2 FOXP1

4.35e-06273227224915
Pubmed

Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors.

FOXP2 FOXP1

4.35e-06273211358962
Pubmed

Equivalent missense variant in the FOXP2 and FOXP1 transcription factors causes distinct neurodevelopmental disorders.

FOXP2 FOXP1

4.35e-06273228741757
Pubmed

Compensation between FOXP transcription factors maintains proper striatal function.

FOXP2 FOXP1

4.35e-06273238761373
Pubmed

Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder.

FOXP2 FOXP1

4.35e-06273226647308
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

PBRM1 NOP14 FMR1 CTCF BRD1 YTHDC1 AKAP8L

6.19e-0633073733301849
Pubmed

An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.

RLF PBRM1 BRD1

7.08e-061873324025402
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZXDC OVOL1 PBRM1 FOXP2 CTCF ZNF644 SCAPER FOXP1 ZC3HAV1 ZNF646

7.19e-06808731020412781
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

PBRM1 NOP14 CTCF DDX27 AKAP8L GTF3C4 ZC3HAV1 WDTC1

7.96e-0648373836912080
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PBRM1 NOP14 FMR1 CTCF SYNE2 NUP210 NUP88 DDX27 ZC3HAV1

9.14e-0665373922586326
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

PRDM10 NOP14 FOXP2 ZNF644 MECOM FOXP1 FNBP1L YTHDC1 PRDM15 GTF3C4

1.20e-05857731025609649
Pubmed

Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues.

FOXP2 FOXP1

1.30e-05373214516685
Pubmed

Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.

PRKCI PHLPP2

1.30e-05373227760826
Pubmed

Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.

UGT1A8 UGT1A9

1.30e-05373229519853
Pubmed

Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1α and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.

UGT1A8 UGT1A9

1.30e-05373223721685
Pubmed

Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9.

UGT1A8 UGT1A9

1.30e-05373226247833
Pubmed

Human-specific transcriptional regulation of CNS development genes by FOXP2.

FOXP2 FOXP1

1.30e-05373219907493
Pubmed

The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers.

UGT1A8 UGT1A9

1.30e-05373217339869
Pubmed

Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes, VLDLR and CNTNAP2 in the Zebra Finch Song System.

FOXP2 FOXP1

1.30e-05373228507505
Pubmed

UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients.

UGT1A8 UGT1A9

1.30e-05373219225446
Pubmed

PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes.

PRKCI PRKCQ

1.30e-05373217588663
Pubmed

Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).

ADGRB1 ADGRB3

1.30e-0537329533023
Pubmed

Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.

ADGRB1 ADGRB3

1.30e-05373215225653
Pubmed

Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain.

FOXP2 FOXP1

1.30e-05373212687690
Pubmed

The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops.

CTCF MECOM

1.30e-05373234584081
Pubmed

Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.

UGT1A8 UGT1A9

1.30e-05373216397224
Pubmed

Transcriptional regulation by FOXP1, FOXP2, and FOXP4 dimerization.

FOXP2 FOXP1

1.30e-05373225027557
Pubmed

Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region.

UGT1A8 UGT1A9

1.30e-05373212847094
Pubmed

Foxp1 expression is essential for sex-specific murine neonatal ultrasonic vocalization.

FOXP2 FOXP1

1.30e-05373228204507
Pubmed

Role of CTCF protein in regulating FMR1 locus transcription.

FMR1 CTCF

1.30e-05373223874213
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

RLF ZXDC ZNF276 OVOL1 PBRM1 FOXP2 GLI2 SP6 ZFHX2

1.75e-0570973922988430
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

NOP14 FMR1 CEP78 MRPL10 GEMIN6 YTHDC1 AKAP8L GTF3C4 ZC3HAV1

1.83e-0571373929802200
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

RAF1 PBRM1 SYNE2 MECOM FOXP1 GEMIN6 AKAP8L

2.08e-0539873735016035
Pubmed

Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions.

FOXP2 FOXP1

2.60e-05473214701752
Pubmed

Influence of uridine diphosphate (UDP)-glucuronosyltransferases and ABCC2 genetic polymorphisms on the pharmacokinetics of mycophenolic acid and its metabolites in Chinese renal transplant recipients.

UGT1A8 UGT1A9

2.60e-05473218946804
Pubmed

Population pharmacokinetics and pharmacogenetics of mycophenolic acid following administration of mycophenolate mofetil in de novo pediatric renal-transplant patients.

UGT1A8 UGT1A9

2.60e-05473220147615
Pubmed

Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.

RLF RAF1

2.60e-05473214597674
Pubmed

Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs.

FOXP2 FOXP1

2.60e-05473233525513
Pubmed

Identification and characterization of T reg-like cells in zebrafish.

FOXP2 FOXP1

2.60e-05473229066577
Pubmed

Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the axillary microbiome in a Japanese population.

OVOL1 ABCC11

2.60e-05473235078690
Pubmed

Genetic polymorphisms of UGT1A8, UGT1A9, UGT2B7 and ABCC2 in Chinese renal transplant recipients and a comparison with other ethnic populations.

UGT1A8 UGT1A9

2.60e-05473223700788
Pubmed

PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.

RAF1 PHLPP2

2.60e-05473224530606
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PBRM1 NOP14 FMR1 CEP78 SCAPER DDX27 AKAP8L GTF3C4 ZC3HAV1

2.99e-0575973935915203
Pubmed

Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.

FOXP2 GLI2 FOXP1

3.46e-053073325804738
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PBRM1 NOP14 FMR1 MECOM BRD1 DDX27 AKAP8L ZC3HAV1

3.99e-0560573828977666
Pubmed

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

NDST3 POTEF TRIM49C UGT1A9 GEMIN6 YTHDC1 CXCR1

4.04e-0544273715815621
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

RLF PBRM1 NOP14 CTCF GLI2 ZNF652 ZNF644 NUP210 YTHDC1 GTF3C4 ZNF646

4.04e-051203731129180619
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

RLF PBRM1 NOP14 JADE3 ZNF644 BRD1 PRDM15 GTF3C4

4.13e-0560873836089195
Pubmed

The interaction of protein kinase C isozymes alpha, iota, and theta with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor.

PRKCI PRKCQ

4.33e-05573215192100
Pubmed

The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex.

FOXP2 FOXP1

4.33e-05573227383233
Pubmed

Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele.

UGT1A8 UGT1A9

4.33e-05573220565459
Pubmed

Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.

UGT1A8 UGT1A9

4.33e-05573215057901
Pubmed

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

RAF1 CEP78 WDTC1

6.03e-053673335379950
Pubmed

Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.

UGT1A8 UGT1A9

6.48e-05673232527940
Pubmed

Generation of mice with a conditional Foxp2 null allele.

FOXP2 FOXP1

6.48e-05673217619227
Pubmed

Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes.

UGT1A8 UGT1A9

6.48e-05673220297805
Pubmed

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

FOXP2 FOXP1

6.48e-05673228591638
Pubmed

Cre fate mapping reveals lineage specific defects in neuronal migration with loss of Pitx2 function in the developing mouse hypothalamus and subthalamic nucleus.

FOXP2 FOXP1

6.48e-05673218206388
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ZNF652 SYNE2 CIT PHLPP2

6.50e-0510273410231032
Pubmed

The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung.

FOXP2 GLI2 FOXP1

7.10e-053873337497597
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

NOP14 ZNF644 NUP210 NUP88 GEMIN6 DDX27

8.33e-0534173632971831
Pubmed

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.

UGT1A8 UGT1A9

9.06e-0577328467709
Pubmed

Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6.

FOXP2 FOXP1

9.06e-05773220185820
Pubmed

14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells.

RAF1 PRKCQ

9.06e-05773210433554
Pubmed

Endothelial RAF1/ERK activation regulates arterial morphogenesis.

RAF1 GJA5

9.06e-05773223529931
Pubmed

Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).

UGT1A8 UGT1A9

9.06e-0577328464825
Pubmed

Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.

UGT1A8 UGT1A9

9.06e-05773227514509
Pubmed

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.

UGT1A8 UGT1A9

1.21e-04873217179145
Pubmed

Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization.

RAF1 GJA5

1.21e-0487321376319
Pubmed

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.

UGT1A8 UGT1A9

1.21e-04873220610558
Pubmed

Tangential migration of corridor guidepost neurons contributes to anxiety circuits.

FOXP2 FOXP1

1.21e-04873228921616
Pubmed

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.

UGT1A8 UGT1A9

1.21e-04873218052087
Pubmed

Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development.

FOXP2 FOXP1

1.21e-04873226969076
Pubmed

PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells.

RAF1 PRKCQ

1.21e-04873226973648
Pubmed

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

UGT1A8 UGT1A9

1.55e-04973222511988
Pubmed

Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.

PRKCI PRKCQ

1.55e-0497327850771
Pubmed

Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.

PRKCI PRKCQ

1.55e-0497328206685
Pubmed

Foxg1 suppresses early cortical cell fate.

FOXP2 FOXP1

1.55e-04973214704420
Pubmed

Regulation of HIV-1 gag protein subcellular targeting by protein kinase C.

PRKCI PRKCQ

1.55e-0497327876252
Pubmed

Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.

UGT1A8 UGT1A9

1.55e-04973220732626
Pubmed

Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse.

FOXP2 FOXP1

1.55e-04973233230547
Pubmed

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

UGT1A8 UGT1A9

1.55e-0497321339448
Pubmed

Phosphorylation of HIV-1 gag proteins by protein kinase C.

PRKCI PRKCQ

1.55e-0497328473314
InteractionNUP43 interactions

RLF CASP8AP2 PBRM1 NOP14 JADE3 CTCF ZNF644 SYNE2 NUP88 YTHDC1 CIT DDX27 PPM1A

3.39e-076257313int:NUP43
InteractionCBX3 interactions

RLF RAF1 PRDM10 NOP14 FMR1 JADE3 SMYD1 ZNF644 MECOM BRD1 CIT GTF3C4 ZNF646

4.92e-076467313int:CBX3
InteractionKLF8 interactions

RLF PBRM1 NOP14 CTCF ZNF644 MECOM FOXP1 DDX27 AKAP8L

2.86e-06329739int:KLF8
InteractionCRX interactions

RLF PBRM1 FOXP2 ZNF644 MECOM FOXP1 PRKCI SEC14L4

3.78e-06254738int:CRX
InteractionH1-7 interactions

PRDM10 NOP14 CTCF MRPL10 PRDM15 ZC3HAV1 ZNF646

3.86e-06179737int:H1-7
InteractionNPM1 interactions

RAF1 PRDM10 PBRM1 FMR1 JADE3 CTCF SYNE2 MRPL10 PRKCI ANKRD18A BRD1 CIT DDX27 GTF3C4 ZC3HAV1 WDTC1

4.80e-0612017316int:NPM1
InteractionSOX13 interactions

FOXP2 MECOM FOXP1 YTHDC1

7.62e-0635734int:SOX13
InteractionFEV interactions

RLF PBRM1 FOXP2 CTCF ZNF644 MECOM FOXP1

8.81e-06203737int:FEV
InteractionYBX2 interactions

PRDM10 NOP14 CTCF MRPL10 YTHDC1 PRDM15 DDX27 ZC3HAV1

9.73e-06289738int:YBX2
InteractionH2AB3 interactions

NOP14 CTCF PRDM15 DDX27 ZC3HAV1 ZNF646

9.93e-06136736int:H2AB3
InteractionKLF15 interactions

PBRM1 NOP14 CTCF GLI2 ZNF644 MRPL10 DDX27 AKAP8L

9.98e-06290738int:KLF15
InteractionRPS16 interactions

PRDM10 PBRM1 NOP14 FMR1 CTCF FOXP1 FNBP1L CIT PRDM15 DDX27 GTF3C4 WDTC1

1.04e-057247312int:RPS16
InteractionSRSF4 interactions

PRDM10 CTCF YTHDC1 PRDM15 DDX27 ZC3HAV1 WDTC1 ZNF646

1.28e-05300738int:SRSF4
InteractionMTDH interactions

ZXDC RAF1 FMR1 JADE3 CTCF NUP210 CIT DDX27 GTF3C4 ZC3HAV1

1.35e-055057310int:MTDH
InteractionOASL interactions

PRDM10 NOP14 CIT PRDM15 DDX27 ZC3HAV1 ZNF646

1.62e-05223737int:OASL
InteractionFBL interactions

RAF1 NOP14 FMR1 CTCF ZNF644 PRKCI BRD1 CIT DDX27 ZC3HAV1 WDTC1

1.78e-056397311int:FBL
InteractionGPATCH4 interactions

RAF1 NOP14 NEIL3 CIT PRDM15 DDX27 ZC3HAV1

2.09e-05232737int:GPATCH4
InteractionKLF9 interactions

RLF PBRM1 CTCF ZNF644 DDX27

2.20e-0593735int:KLF9
InteractionKLF16 interactions

RLF RAF1 NOP14 CTCF ZNF644 MECOM FOXP1 DDX27 AKAP8L

2.23e-05425739int:KLF16
InteractionCHD4 interactions

RAF1 PBRM1 NOP14 FMR1 MCPH1 ZNF644 MECOM PRKCI BRD1 CIT DDX27 AKAP8L ZC3HAV1

2.85e-059387313int:CHD4
InteractionCOIL interactions

RLF RAF1 CASP8AP2 PBRM1 NOP14 JADE3 ZNF644 YTHDC1 CIT GTF3C4

2.89e-055527310int:COIL
InteractionBRD1 interactions

RAF1 PBRM1 JADE3 CTCF FOXP1 BRD1 AKAP8L WDTC1

3.40e-05344738int:BRD1
InteractionZBTB2 interactions

PBRM1 NOP14 FMR1 FOXP2 CTCF FOXP1 BRD1 YTHDC1 AKAP8L

3.49e-05450739int:ZBTB2
InteractionMACROH2A1 interactions

RLF RAF1 PBRM1 FMR1 CTCF MECOM CIT AKAP8L GTF3C4

4.00e-05458739int:MACROH2A1
InteractionTEAD1 interactions

RLF PBRM1 CTCF ZNF644 FOXP1 CIT

4.27e-05176736int:TEAD1
InteractionRBM4B interactions

RAF1 CTCF SMYD1 CIT PRDM15 DDX27 ZC3HAV1

4.54e-05262737int:RBM4B
InteractionIFI16 interactions

PBRM1 NOP14 FMR1 CTCF NUP88 BRD1 YTHDC1 CIT DDX27 GTF3C4 ZC3HAV1

4.92e-057147311int:IFI16
InteractionLHX2 interactions

PBRM1 CTCF ZNF644 ZNF511 FOXP1 DDX27

5.31e-05183736int:LHX2
InteractionGNL3 interactions

RAF1 NOP14 CTCF MECOM BRD1 CIT PRDM15 DDX27

5.47e-05368738int:GNL3
InteractionLHX3 interactions

PBRM1 ZNF644 SYNE2 FOXP1 DDX27 IQUB

5.64e-05185736int:LHX3
InteractionRPL23A interactions

PRDM10 NOP14 CTCF FOXP1 YTHDC1 CIT PRDM15 DDX27 ZC3HAV1 WDTC1

6.34e-056067310int:RPL23A
InteractionRPL28 interactions

FMR1 CTCF ZNF644 FOXP1 CIT PRDM15 DDX27 ZC3HAV1 WDTC1

7.17e-05494739int:RPL28
InteractionMEN1 interactions

PBRM1 NOP14 CTCF ZNF644 NUP210 NUP88 FOXP1 GEMIN6 YTHDC1 DDX27 AKAP8L GTF3C4 ZC3HAV1

7.38e-0510297313int:MEN1
InteractionZNF281 interactions

GLI2 ZNF652 ZNF644 MECOM BRD1 CIT

7.99e-05197736int:ZNF281
InteractionPHIP interactions

PBRM1 FOXP2 MECOM FOXP1 CIT AKAP8L

7.99e-05197736int:PHIP
InteractionMAGI3 interactions

FMR1 ADGRB1 MECOM CIT

8.03e-0563734int:MAGI3
InteractionSRSF6 interactions

PRDM10 NOP14 CTCF MECOM YTHDC1 CIT PRDM15 DDX27 ZC3HAV1

8.23e-05503739int:SRSF6
InteractionSNRNP40 interactions

RAF1 CASP8AP2 PRDM10 NOP14 JADE3 CTCF ZNF644 YTHDC1 CIT DDX27

9.58e-056377310int:SNRNP40
InteractionPRKRA interactions

RAF1 PRDM10 CTCF NEIL3 PRDM15 DDX27 ZC3HAV1 ZNF646

9.79e-05400738int:PRKRA
InteractionTARBP2 interactions

RAF1 TCEA2 FOXP1 BRD1 DDX27

1.13e-04131735int:TARBP2
InteractionKDM1A interactions

RLF RAF1 CASP8AP2 FMR1 MCPH1 ZNF644 NUP88 MECOM FOXP1 CIT AKAP8L GTF3C4

1.33e-049417312int:KDM1A
InteractionZFHX4 interactions

DPRX FOXP2 FOXP1 BRD1

1.43e-0473734int:ZFHX4
InteractionDOT1L interactions

PBRM1 NOP14 FMR1 CTCF NUP210 FOXP1 YTHDC1 DDX27 AKAP8L GTF3C4 ZC3HAV1

1.46e-048077311int:DOT1L
InteractionRBM19 interactions

RAF1 NOP14 CTCF CIT DDX27 ZC3HAV1

1.50e-04221736int:RBM19
InteractionHDAC1 interactions

RLF RAF1 CASP8AP2 OVOL1 CTCF SMYD1 GLI2 SYNE2 NUP88 MECOM HIGD1C CIT AKAP8L

1.55e-0411087313int:HDAC1
InteractionPURG interactions

NOP14 CTCF YTHDC1 PRDM15 DDX27 ZC3HAV1

1.57e-04223736int:PURG
InteractionH1-6 interactions

PRDM10 YTHDC1 CIT DDX27 ZC3HAV1 WDTC1

1.82e-04229736int:H1-6
InteractionEMSY interactions

FMR1 FOXP2 NUP88 FOXP1 ZNF646

1.82e-04145735int:EMSY
InteractionSYT10 interactions

CIT WDTC1

1.92e-046732int:SYT10
InteractionCDY2B interactions

ZNF644 MECOM

1.92e-046732int:CDY2B
InteractionSEC14L3 interactions

CIT SEC14L4

1.92e-046732int:SEC14L3
InteractionGAR1 interactions

RAF1 NOP14 FGD1 FOXP1 CIT DDX27

1.95e-04232736int:GAR1
InteractionSNRNP70 interactions

RAF1 NOP14 FMR1 CEP78 MRPL10 FOXP1 GEMIN6 YTHDC1 CIT AKAP8L GTF3C4 ZC3HAV1

2.01e-049847312int:SNRNP70
InteractionPRDM5 interactions

PRDM10 CTCF GLI2 ZNF652

2.04e-0480734int:PRDM5
InteractionZNF526 interactions

TCEA2 BRD1 YTHDC1 IQUB

2.04e-0480734int:ZNF526
InteractionZNF330 interactions

RLF PBRM1 NOP14 ZNF644 BRD1 YTHDC1 PRDM15 DDX27

2.06e-04446738int:ZNF330
InteractionH2BC8 interactions

RLF PBRM1 NOP14 JADE3 CTCF ZNF644 BRD1 PRDM15 GTF3C4

2.28e-04576739int:H2BC8
InteractionYY1 interactions

RAF1 PBRM1 FOXP2 CTCF ZNF644 MECOM FOXP1 BRD1

2.33e-04454738int:YY1
InteractionLARP4B interactions

RAF1 FMR1 YTHDC1 CIT ZC3HAV1 WDTC1

2.34e-04240736int:LARP4B
InteractionMAGED2 interactions

RAF1 TCEA2 CTCF MECOM PRKCI CIT

2.51e-04243736int:MAGED2
InteractionSMARCA4 interactions

RAF1 PBRM1 FMR1 MCPH1 CTCF MECOM NEIL3 CIT

2.62e-04462738int:SMARCA4
InteractionZBTB48 interactions

PBRM1 CTCF GLI2 DDX27 ZC3HAV1

2.72e-04158735int:ZBTB48
InteractionDES interactions

TCEA2 NEK6 NUP88 MECOM CIT

2.72e-04158735int:DES
InteractionNUMA1 interactions

RLF RAF1 PBRM1 FMR1 NUP210 NUP88 BRD1 CIT

2.90e-04469738int:NUMA1
InteractionNEFL interactions

FMR1 NEK6 SMYD1 NEIL3 CIT

2.96e-04161735int:NEFL
InteractionSRSF5 interactions

RAF1 PRDM10 CTCF CIT PRDM15 DDX27 ZC3HAV1 ZNF646

3.11e-04474738int:SRSF5
InteractionRAN interactions

RAF1 CTCF ZNF644 NUP210 NUP88 MECOM FOXP1 CIT

3.15e-04475738int:RAN
InteractionPUM3 interactions

RAF1 CTCF MECOM CIT DDX27 ZC3HAV1

3.18e-04254736int:PUM3
InteractionCIRBP interactions

RAF1 FMR1 NUP88 NEIL3 BRD1

3.23e-04164735int:CIRBP
InteractionNUP62CL interactions

NUP88 FOXP1 CIT

3.24e-0437733int:NUP62CL
InteractionSIRT7 interactions

RAF1 PBRM1 NOP14 FMR1 CTCF SYNE2 NUP210 NUP88 DDX27 ZC3HAV1

3.36e-047447310int:SIRT7
InteractionFGFBP1 interactions

PBRM1 NOP14 CTCF PRDM15 DDX27 ZC3HAV1

3.38e-04257736int:FGFBP1
InteractionBRPF3 interactions

JADE3 SCAPER BRD1 AKAP8L ZNF646

3.41e-04166735int:BRPF3
InteractionPOLR1G interactions

PBRM1 NOP14 JADE3 CTCF ZNF644 CIT DDX27 GTF3C4

3.83e-04489738int:POLR1G
InteractionEGR2 interactions

FOXP2 ZNF644 MECOM FOXP1 AKAP8L

3.91e-04171735int:EGR2
InteractionLYAR interactions

RAF1 CTCF BRD1 CIT PRDM15 DDX27 ZC3HAV1

4.01e-04373737int:LYAR
InteractionELMO1 interactions

ADGRB1 ADGRB3 FGD1

4.09e-0440733int:ELMO1
InteractionDPM1 interactions

RAF1 PRKCI BRD1 CIT WDTC1

4.12e-04173735int:DPM1
InteractionH3C3 interactions

RLF PBRM1 NOP14 JADE3 ZNF644 BRD1 PRDM15 GTF3C4

4.15e-04495738int:H3C3
InteractionZNF346 interactions

PRDM10 NOP14 CTCF POTEF YTHDC1 DDX27 ZC3HAV1

4.28e-04377737int:ZNF346
InteractionCENPA interactions

RLF PBRM1 NOP14 JADE3 ZNF644 MECOM GTF3C4

4.28e-04377737int:CENPA
InteractionSIRT6 interactions

PBRM1 FMR1 ZNF644 NUP210 NUP88 DDX27 AKAP8L GTF3C4 ZC3HAV1

4.29e-04628739int:SIRT6
InteractionSTRAP interactions

RAF1 FMR1 FOXP1 NEIL3 GEMIN6 ZC3HAV1

4.39e-04270736int:STRAP
InteractionARHGAP44 interactions

SYNE2 FNBP1L WDTC1

4.40e-0441733int:ARHGAP44
InteractionKRR1 interactions

RAF1 PRDM10 NOP14 CTCF DDX27 ZC3HAV1 ZNF646

4.42e-04379737int:KRR1
InteractionDNAJB6 interactions

RAF1 ZNF644 MECOM BRD1 DDX27 AKAP8L WDTC1

4.42e-04379737int:DNAJB6
InteractionGLI3 interactions

CTCF GLI2 ZNF652 BRD1

4.43e-0498734int:GLI3
InteractionTCHHL1 interactions

RAF1 PBRM1

4.58e-049732int:TCHHL1
InteractionTLR6 interactions

YTHDC1 IQUB

4.58e-049732int:TLR6
InteractionSEC16B interactions

RAF1 POTEF

4.58e-049732int:SEC16B
InteractionNEIL1 interactions

PRDM10 CTCF MRPL10 PRDM15 DDX27 ZC3HAV1

4.93e-04276736int:NEIL1
InteractionNUP160 interactions

RAF1 PBRM1 NUP88 MECOM CIT

5.33e-04183735int:NUP160
InteractionLHX1 interactions

PBRM1 CTCF ZNF644 DDX27

5.34e-04103734int:LHX1
InteractionMEAF6 interactions

RAF1 ZNF276 JADE3 BRD1

5.54e-04104734int:MEAF6
InteractionCBX6 interactions

KLHL3 NOP14 CTCF ZNF644 DDX27 ZC3HAV1

5.63e-04283736int:CBX6
InteractionCSDE1 interactions

RAF1 FMR1 FOXP1 NEIL3 ZC3HAV1 WDTC1

5.73e-04284736int:CSDE1
InteractionZNF644 interactions

RLF DPRX ZNF644 YTHDC1 GTF3C4

5.74e-04186735int:ZNF644
InteractionLGALS3BP interactions

RAF1 FMR1 GLI2 MECOM BRD1 CIT

5.95e-04286736int:LGALS3BP
InteractionPTBP3 interactions

RAF1 UGT1A8 YTHDC1 CIT DDX27

6.02e-04188735int:PTBP3
InteractionRPLP0 interactions

PRDM10 PBRM1 FMR1 CTCF CIT PRDM15 DDX27 PPM1A ZC3HAV1

6.14e-04660739int:RPLP0
Cytoband17q21.32

ZNF652 SP6 MRPL10

6.74e-054973317q21.32
Cytoband2q37

UGT1A8 UGT1A9

1.13e-03317322q37
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

RLF ZXDC PRDM10 ZNF276 OVOL1 CTCF GLI2 ZNF652 SCAPER SP6 ZFHX2 ZNF511 MECOM PRDM15 ZNF646

1.70e-09718541528
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

PRDM10 MECOM PRDM15

1.66e-05175431197
GeneFamilyAdhesion G protein-coupled receptors, subfamily B

ADGRB1 ADGRB3

2.62e-053542912
GeneFamilyProtein phosphatases, Mg2+/Mn2+ dependent

PPM1A PHLPP2

1.16e-0317542701
GeneFamilyNucleoporins

NUP210 NUP88

4.10e-03325421051
GeneFamilyUDP glucuronosyltransferases

UGT1A8 UGT1A9

4.10e-0332542363
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SMYD1 MECOM

4.62e-0334542487
GeneFamilyForkhead boxes

FOXP2 FOXP1

7.31e-0343542508
CoexpressionPYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP

CASP8AP2 FMR1 MCPH1 NUP210 MECOM FNBP1L PRDM15 PPM1A

6.47e-08195728M13736
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

CASP8AP2 PRDM10 PBRM1 JADE3 CTCF ZNF644

6.23e-0718673603db813598b67b1e08f759758a1c2023396921fa
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

RLF JADE3 ZNF644 BRD1 YTHDC1

1.56e-051917351ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CEP78 SYNE2 MRPL10 PRKCQ BRD1

1.76e-05196735c100967851f037b3522130a9e2a4175ad593ecbc
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

NOP14 FOXP2 SYNE2 SCAPER PRKCQ

1.80e-051977351a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

SCAPER ANKRD18A CNTLN YTHDC1 DDX27

1.80e-051977350fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCellsevere_COVID-19-CD8+_Tem|severe_COVID-19 / disease group, cell group and cell class (v2)

ZNF276 SYNE2 MRPL10 PRKCQ BRD1

1.85e-0519873569d49f37cf5095e65c71cddc6d43748322ff19a3
Drug4'-HPPH

MCPH1 GUSB UGT1A8 UGT1A9

2.56e-0631714CID000017732
DrugGlucuronides

GUSB UGT1A8 UGT1A9

3.43e-0610713ctd:D020719
DrugPPL-L-alanine

FMR1 FOXP2 SYNE2 PRKCI PRKCQ

5.79e-0682715CID000444773
DrugN-OH-DABZ

GUSB UGT1A8 UGT1A9

6.27e-0612713CID000051366
DrugZ 338

UGT1A8 UGT1A9

9.59e-062712ctd:C410959
Drugnaphthyl sulphate

GUSB UGT1A8 UGT1A9

1.29e-0515713CID000114775
DrugAzitidin

UGT1A8 UGT1A9 PRKCI PRKCQ CIT ZC3HAV1

1.47e-05169716CID000005726
DrugAC1ND2OB

RAF1 FOXP2 UGT1A8 UGT1A9 PRKCI PRKCQ WDTC1

1.88e-05265717CID004568637
Drugethyl-beta-D-6-glucosiduronic acid

GUSB UGT1A8 UGT1A9

2.29e-0518713CID000152226
Drugstanolone benzoate

FOXP2 FOXP1

2.87e-053712ctd:C040109
DrugAC1L1OBF

GUSB UGT1A8 UGT1A9

3.19e-0520713CID000032736
DrugBuflomedil hydrochloride [35543-24-9]; Down 200; 11.6uM; MCF7; HT_HG-U133A

OVOL1 ZNF652 NUP210 SCAPER BRD1 ZC3HAV1

3.20e-051947163274_DN
Drug5666823; Down 200; 100uM; MCF7; HG-U133A

KLHL3 ZNF276 OVOL1 NUP210 FGD1 PRKCQ

3.30e-05195716609_DN
DrugGuanfacine hydrochloride [29110-48-3]; Up 200; 14.2uM; HL60; HT_HG-U133A

FNBP1L CNTLN DDX27 GTF3C4 PPM1A WDTC1

3.49e-051977161279_UP
Drugestradiol-3-glucuronide

GUSB UGT1A8 UGT1A9

4.92e-0523713CID000066651
Drugethoxytriethyleneglycol

UGT1A8 UGT1A9 PRKCI PRKCQ

5.41e-0566714CID000008190
DrugN-acetylbenzidine

GUSB UGT1A8 UGT1A9

6.36e-0525713CID000018787
Drugnitrosamine

PBRM1 UGT1A8 UGT1A9 CIT

6.81e-0570714CID000037183
Drugprocyanidin

FOXP2 PRKCI PRKCQ WDTC1

7.20e-0571714CID000107876
DrugC-1b

RAF1 DGKG PRKCI PRKCQ

7.61e-0572714CID006102740
Drugdiflunisal

GUSB UGT1A8 UGT1A9

8.06e-0527713CID000003059
DrugN-hydroxy-4-aminobiphenyl

GUSB UGT1A8 UGT1A9

9.00e-0528713CID000081261
Drugnaringenin chalcone

UGT1A8 UGT1A9

9.53e-055712ctd:C027329
Druganthrarobin

UGT1A8 UGT1A9

9.53e-055712ctd:C032186
Drug2,4,4'-trichlorobiphenyl

RAF1 PBRM1 FOXP2 SMYD1 GLI2 SYNE2 FGD1 DGKG FOXP1 NEIL3 GEMIN6 FNBP1L CNTLN ZNF646

9.92e-0514117114ctd:C081766
DrugAC1L1JAL

UGT1A8 UGT1A9 PPM1A

1.00e-0429713CID000004954
Drugtrans-3'-hydroxycotinine

GUSB UGT1A8 UGT1A9

1.00e-0429713CID000000414
Drug7-hydroxycoumarin glucuronide

GUSB UGT1A8 UGT1A9

1.00e-0429713CID000125641
DrugAC1L9E0Q

GUSB UGT1A8 UGT1A9

1.11e-0430713CID000443095
Drug2,4,5,2',5'-pentachlorobiphenyl

RAF1 PBRM1 FOXP2 SMYD1 GLI2 SYNE2 FGD1 DGKG FOXP1 NEIL3 GEMIN6 FNBP1L CNTLN ZNF646

1.24e-0414417114ctd:C009828
Drugphenylbutazone

GUSB UGT1A8 UGT1A9 GEMIN6

1.32e-0483714CID000004781
DrugNNAL

GUSB UGT1A8 UGT1A9

1.35e-0432713CID000104856
Drug1,2,5,8-tetrahydroxy anthraquinone

UGT1A8 UGT1A9

1.43e-046712ctd:C543211
Drugoroxindin

GUSB CIT

1.43e-046712CID003084961
Drugalloin

UGT1A8 UGT1A9

1.43e-046712ctd:C006457
Drug2',5'-dihydroxychalcone

UGT1A8 UGT1A9

1.43e-046712ctd:C107497
DrugAC1Q6OQG

GUSB UGT1A8 UGT1A9

1.48e-0433713CID000009686
DrugKetoprofen

GUSB UGT1A9 CXCR1

1.48e-0433713ctd:D007660
Drugnorbuprenorphine

GUSB UGT1A8 UGT1A9

1.48e-0433713CID000114976
Druggeniposide

GUSB UGT1A8 UGT1A9

1.48e-0433713CID000107848
DrugAC1LCF1F

GUSB UGT1A8 UGT1A9 ABCC11 BRD1

1.48e-04161715CID000627275
DrugAC1NOWCJ

GUSB UGT1A8 UGT1A9

1.77e-0435713CID005120112
Drug3-[(3S,5R,10S,13R,14S,17R)-3-[(2S,4R,5R,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

GUSB UGT1A8 UGT1A9

1.77e-0435713CID010436171
Drugl 1400

GUSB KCNN1

1.99e-047712CID000015548
Drug2',4'-dihydroxychalcone

UGT1A8 UGT1A9

1.99e-047712ctd:C059354
DrugFim 1

RAF1 MECOM PRKCI

2.09e-0437713CID000132906
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

PRDM10 JADE3 CTCF NUP210 BRD1

2.13e-041747151659_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

PRDM10 CTCF KCNN1 FGD1 PPM1A

2.19e-041757155935_DN
DrugTCPOBOP

FOXP2 SMYD1 UGT1A8 UGT1A9

2.23e-0495714CID000005382
Drugethoxyresorufin

PBRM1 SMYD1 UGT1A8 UGT1A9

2.23e-0495714CID000003294
Drug4-methylumbelliferyl glucuronide

GUSB UGT1A8 UGT1A9

2.27e-0438713CID000091553
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

PRDM10 CTCF NUP210 BRD1 PPM1A

2.31e-041777157550_DN
Diseaseblood 4-oxo-retinoic acid measurement

UGT1A8 UGT1A9

1.61e-053692EFO_0022216
Diseaseindole-3-carboxylate measurement

UGT1A8 UGT1A9

1.61e-053692EFO_0800043
Diseasechildhood trauma measurement

NDST3 FOXP2 FOXP1

2.39e-0524693EFO_0007979
Diseasespecific developmental disorder (implicated_via_orthology)

FOXP2 FOXP1

3.22e-054692DOID:0060038 (implicated_via_orthology)
DiseaseN-acetyl-4-chlorophenylalanine measurement

UGT1A8 UGT1A9

5.36e-055692EFO_0801060
Disease5-hydroxyindole sulfate measurement

UGT1A8 UGT1A9

5.36e-055692EFO_0800085
Diseasenuclear receptor subfamily 1 group D member 2 measurement

UGT1A8 UGT1A9

5.36e-055692EFO_0801853
Disease3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) measurement

UGT1A8 UGT1A9

8.03e-056692EFO_0800566
Diseasehair color

ZNF276 OVOL1 NEK6 SYNE2 SP6 PPM1A

8.97e-05311696EFO_0003924
DiseaseX-21339 measurement

UGT1A8 UGT1A9

1.12e-047692EFO_0800808
Diseaseinvasive ductal carcinoma (is_marker_for)

ADGRB1 FGD1 PRKCI

1.14e-0440693DOID:3008 (is_marker_for)
DiseaseX-11793--oxidized bilirubin measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0021260
DiseaseSuccinimide measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0022118
DiseaseX-11530 measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0021249
Diseasesulfate of piperine metabolite C16H19NO3 (2) measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0801034
Diseasecholelithiasis, bilirubin measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0004570, EFO_0004799
DiseaseX-11522 measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0800696
DiseaseX-10458 measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0800692
DiseaseX-24849 measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0800909
Diseaseserum N-desmethylclozapine measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0600043
Diseaseplasma clozapine measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0600038
Diseasemembrane-associated progesterone receptor component 1 measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0802740
DiseaseX-16946 measurement

UGT1A8 UGT1A9

1.50e-048692EFO_0800766
DiseaseX-11442 measurement

UGT1A8 UGT1A9

1.92e-049692EFO_0021236
DiseaseX-11441 measurement

UGT1A8 UGT1A9

1.92e-049692EFO_0021235
Diseasecirculating cell free DNA measurement

UGT1A8 UGT1A9

1.92e-049692EFO_0004739
Diseasesulfate of piperine metabolite C18H21NO3 (3) measurement

UGT1A8 UGT1A9

1.92e-049692EFO_0801037
Diseasetestis-specific chromodomain protein Y 1 measurement

UGT1A8 UGT1A9

1.92e-049692EFO_0802127
Diseasesulfate of piperine metabolite C18H21NO3 (1) measurement

UGT1A8 UGT1A9

1.92e-049692EFO_0801036
DiseaseX-11880 measurement

UGT1A8 UGT1A9

1.92e-049692EFO_0800698
Diseasebilirubin measurement, response to xenobiotic stimulus

UGT1A8 UGT1A9

1.92e-049692EFO_0004570, GO_0009410
Diseaseprotein-tyrosine kinase 6 measurement

UGT1A8 UGT1A9

1.92e-049692EFO_0020691
Diseaseindoleacetate measurement

UGT1A8 UGT1A9

2.40e-0410692EFO_0021015
DiseaseX-21448 measurement

UGT1A8 UGT1A9

2.40e-0410692EFO_0800816
DiseaseUDP-glucuronosyltransferase 1-6 measurement

UGT1A8 UGT1A9

2.40e-0410692EFO_0802185
DiseaseX-23974 measurement

UGT1A8 UGT1A9

2.40e-0410692EFO_0800867
Diseasebilirubin measurement, response to tenofovir

UGT1A8 UGT1A9

2.40e-0410692EFO_0004570, EFO_0009279
DiseaseX-21796 measurement

UGT1A8 UGT1A9

2.92e-0411692EFO_0800825
Diseasepregnenetriol sulfate measurement

UGT1A8 UGT1A9

2.92e-0411692EFO_0800586
Diseaseplasma N-desmethylclozapine measurement

UGT1A8 UGT1A9

2.92e-0411692EFO_0600039
Diseaseinsomnia, bilirubin measurement

UGT1A8 UGT1A9

2.92e-0411692EFO_0004570, EFO_0004698
Diseasehistidine betaine (hercynine) measurement

UGT1A8 UGT1A9

2.92e-0411692EFO_0800972
Diseasealdosterone measurement

UGT1A8 UGT1A9

2.92e-0411692EFO_0010219
Diseasebiliverdin measurement

UGT1A8 UGT1A9

3.50e-0412692EFO_0021033
Diseasep-cresol glucuronide measurement

UGT1A8 UGT1A9

3.50e-0412692EFO_0800079
Diseaseasthma

RAF1 OVOL1 NEK6 ZNF652 SP6 MECOM FOXP1 PRKCQ

3.61e-04751698MONDO_0004979
DiseaseX-24588 measurement

UGT1A8 UGT1A9

4.13e-0413692EFO_0800898
Diseaseretinol dehydrogenase 16 measurement

UGT1A8 UGT1A9

4.13e-0413692EFO_0802007
Diseasepregnenetriol disulfate measurement

UGT1A8 UGT1A9

4.13e-0413692EFO_0800587
Diseasehair colour measurement

RAF1 ZNF276 OVOL1 NEK6 SYNE2 SP6 PPM1A

5.82e-04615697EFO_0007822
DiseaseX-21441 measurement

UGT1A8 UGT1A9

7.16e-0417692EFO_0800814
Diseaselevel of Sphingomyelin (d32:1) in blood serum

SYNE2 NUP88

7.16e-0417692OBA_2045173
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

UGT1A8 UGT1A9

7.16e-0417692EFO_0004611, EFO_0007800
Diseasetestosterone measurement

RAF1 OVOL1 UGT1A8 ZNF652 SYNE2 FGD1 UGT1A9 MECOM FOXP1 PRKCQ

7.31e-0412756910EFO_0004908
Diseaseangiopoietin-related protein 1 measurement

UGT1A8 UGT1A9

8.05e-0418692EFO_0801382
Diseaseschizophrenia (is_implicated_in)

FOXP2 FOXP1 BRD1

8.21e-0478693DOID:5419 (is_implicated_in)
Diseasethyroxine measurement

NEK6 UGT1A8 UGT1A9

9.84e-0483693EFO_0005130
Diseasetissue factor measurement

UGT1A8 UGT1A9

1.10e-0321692EFO_0010623
Diseaseprostate carcinoma

NEK6 ZNF652 SYNE2 SP6 MECOM FOXP1 PRKCI PHLPP2

1.10e-03891698EFO_0001663
DiseasePrimary microcephaly

MCPH1 CIT

1.21e-0322692C0431350
DiseaseGranulomatous Slack Skin

CTCF PRKCQ

1.21e-0322692C0376407
DiseaseAutosomal Recessive Primary Microcephaly

MCPH1 CIT

1.21e-0322692C3711387
DiseaseLymphoma, T-Cell, Cutaneous

CTCF PRKCQ

1.32e-0323692C0079773
Diseaselevel of Sphingomyelin (d40:2) in blood serum

SYNE2 NUP88

1.32e-0323692OBA_2045181
Diseaseattention deficit hyperactivity disorder

FOXP2 UGT1A8 UGT1A9 FOXP1 CNTLN

1.45e-03354695EFO_0003888
Diseaseazoospermia (implicated_via_orthology)

NDST3 SCAPER

1.82e-0327692DOID:14227 (implicated_via_orthology)
Diseaseneuroblastoma, cutaneous melanoma

UGT1A8 UGT1A9

1.96e-0328692EFO_0000389, EFO_0000621
Diseasexanthurenate measurement

UGT1A8 UGT1A9

2.10e-0329692EFO_0010551
Diseasewaist-hip ratio

TCEA2 PBRM1 SYNE2 SP6 DGKG MECOM DCST2 CNTLN IQUB

2.16e-031226699EFO_0004343
Diseaseresponse to dolutegravir

UGT1A8 UGT1A9

2.25e-0330692EFO_0600017
Diseaseeosinophil count

TCEA2 PBRM1 NEK6 ZNF652 FOXP1 PRKCI DCST2 GTF3C4 PPM1A ZC3HAV1

2.32e-0314886910EFO_0004842

Protein segments in the cluster

PeptideGeneStartEntry
DHIKHPMDFATMRKR

BRD1

601

O95696
LRQAQHRIKEMKQMH

ANKRD18A

511

Q8IVF6
QERHMIMHKRTHTGE

CTCF

506

P49711
EEHIKEMHEKISRME

CNTLN

1126

Q9NXG0
DFEKIMHTRKRHQDM

ADGRB1

1481

O14514
DLDFEKVMHTRKRHM

ADGRB3

1421

O60242
KVMHTRKRHMELFQE

ADGRB3

1426

O60242
MAKILKYQTMRRHEE

CEP78

196

Q5JTW2
QEIMHMLRMIRKHVR

CASP8AP2

1036

Q9UKL3
HKMEQEMTRLHRRVS

CIT

466

O14578
FEEQMKEIIRMCSHH

DDX27

381

Q96GQ7
VMLFTQTKKQAHRMH

DDX27

466

Q96GQ7
HLKTMDHNRNRRLMM

AKAP8L

501

Q9ULX6
MSFIMKLHRHFQRTV

NDST3

1

O95803
MDYLHAKNIIHRDMK

RAF1

456

P04049
IRHFTDSLKMRKMED

MECOM

1141

Q03112
TMHRLTDKQRKHLSM

NUP210

1646

Q8TEM1
FMAIEEMKKHRSTHV

POTEF

536

A5A3E0
EIEHHEMAKSSLRMR

PBRM1

286

Q86U86
MFHMQRQRKLPEEHA

PRKCI

341

P41743
SRETMFHKERFKIDM

PRKCQ

216

Q04759
RHHSAMEKRLQEMKE

MCPH1

171

Q8NEM0
EQIHHLMKMIRDFSI

NEIL3

216

Q8TAT5
RDQKMSIHLIHMRVA

HIGD1C

51

A8MV81
ERVSYRMSQKVHRKM

HSPB9

91

Q9BQS6
KHVHNFMMDTQLTKR

KCNN1

376

Q92952
SKERERLQAMMTHLH

FOXP2

396

O15409
AKDKERLQAMMTHLH

FOXP1

356

Q9H334
LAVFMTRMAVKAQHH

ABCC11

316

Q96J66
EHMHSRRVMHRDIKP

NEK6

161

Q9HC98
KHMTTMHRFEQLKKE

GLI2

721

P10070
FKRKDKLREHMQRMH

PRDM10

681

Q9NQV6
MMKRFALEQQRHHEK

NOP14

101

P78316
KDQMHSHRKRTMFTK

DPRX

11

A6NFQ7
RMLNRHMKCHNDVKR

OVOL1

131

O14753
HVMREKHPEKFNSRM

DGKG

596

P49619
VTSKRAHMLIDMHFR

FMR1

176

Q06787
LMRYAHDLKTERKMH

FNBP1L

101

Q5T0N5
AMHTVRMQEKRKLRE

GJA5

96

P36382
HMQVMEEVVRRDKNH

GUSB

426

P08236
KAHMGQKHRAMRVIF

CXCR1

231

P25024
AEQHSRLLMMHRIKK

CALHM4

236

Q5JW98
IDREVDLMMRGVKHH

IQUB

541

Q8NA54
ETRLEHMAKLMEHVR

KLHL3

226

Q9UH77
MDLHEAVSMKLHRVR

DCST2

306

Q5T1A1
MNEGDHRVREKLMHL

GEMIN6

71

Q8WXD5
KSEDMLRRHMEFRKQ

SEC14L4

51

Q9UDX3
RRMMEEKLLHAEFKR

SCAPER

591

Q9BY12
KEESIHTRMRMFMHL

JADE3

461

Q92613
IMNRMKKLLHSFHSE

NUP88

636

Q99567
RLHLSKAKMAHRMEI

TRIM49

211

P0CI25
KMTLFKSLMDRFEHH

SYNE2

426

Q8WXH0
KDMLKEHMRVHDNVR

PRDM15

1096

P57071
EHSNAAIRKMERMHK

FGD1

556

P98174
HEAVKSMFHTQMRIE

SMYD1

221

Q8NB12
RVFMRSDHLAKHMKT

SP6

321

Q3SY56
KTSRDRKDHMVRMHL

ZNF511

156

Q8NB15
LYDIRMIHNHRKSMK

WDTC1

211

Q8N5D0
LFTSKHSMKAHMVRQ

ZXDC

461

Q2QGD7
SRNLRIHMTSEKHMQ

ZFHX2

581

Q9C0A1
HIKHVDLRMNHLKTM

PHLPP2

416

Q6ZVD8
FKRKEMFVPHVMEHV

RLF

591

Q13129
HRRVMHFQRQKLMAV

MRPL10

36

Q7Z7H8
LEIDEHMRVMSEKKH

PPM1A

106

P35813
RLHLSKAKMAHRMEI

TRIM49C

211

P0CI26
RRFEKAHNLNVHMSM

ZNF276

561

Q8N554
KHFHTMAAMKNHLRR

ZNF646

651

O15015
IEAVEMHLTREHMKR

GTF3C4

676

Q9UKN8
MHLTREHMKRVLGEV

GTF3C4

681

Q9UKN8
MTFKERVRNHIMHLE

UGT1A9

201

O60656
YQVIHKMRHKRRMHS

YTHDC1

501

Q96MU7
NVNFREKKHLHRHMM

ZNF644

416

Q9H582
HMIIHQERRQKLMEE

ZNF644

466

Q9H582
KAMTKEAIREHQMAR

TCEA2

236

Q15560
HNLMDRKVLAIMREH

ZC3HAV1

191

Q7Z2W4
EKHMNVTHRRMQICD

ZNF652

261

Q9Y2D9
MTFKERVRNHIMHLE

UGT1A8

201

Q9HAW9