Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	integrin binding	DST FN1 LAMB2 ITGAE UTRN TNXB	9.39e-06	175	56	6	GO:0005178
GeneOntologyMolecularFunction	mercury ion binding	TXNRD1 FN1	2.14e-04	8	56	2	GO:0045340
GeneOntologyMolecularFunction	prostaglandin transmembrane transporter activity	SLCO1B3 SLCO1B1	6.88e-04	14	56	2	GO:0015132
GeneOntologyMolecularFunction	icosanoid transmembrane transporter activity	SLCO1B3 SLCO1B1	7.92e-04	15	56	2	GO:0071714
GeneOntologyMolecularFunction	oligopeptide transmembrane transporter activity	SLCO1B3 SLCO1B1	9.04e-04	16	56	2	GO:0035673
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	SLCO1B3 ABCD2 SLCO1B1	1.13e-03	73	56	3	GO:0170055
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO1B3 SLCO1B1	1.15e-03	18	56	2	GO:0015347
GeneOntologyMolecularFunction	cell adhesion molecule binding	DST FN1 EMB LAMB2 ITGAE UTRN TNXB	1.37e-03	599	56	7	GO:0050839
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	SLCO1B3 ABCD2 SLCO1B1	2.07e-03	90	56	3	GO:0008028
GeneOntologyBiologicalProcess	substrate adhesion-dependent cell spreading	NEDD9 FN1 CORO1C FER LAMB2	1.16e-05	109	56	5	GO:0034446
GeneOntologyBiologicalProcess	cell-substrate adhesion	NEDD9 FN1 CORO1C FER LAMB2 ITGAE UTRN TNXB	1.40e-05	410	56	8	GO:0031589
GeneOntologyBiologicalProcess	integrin-mediated signaling pathway	NEDD9 DST FN1 LAMB2 ITGAE	2.16e-05	124	56	5	GO:0007229
GeneOntologyCellularComponent	sarcolemma	DST ANK1 CORO1C RRAD UTRN	1.42e-04	190	55	5	GO:0042383
GeneOntologyCellularComponent	ciliary basal body	NEDD9 AGBL4 IFT140 CSNK1A1L CSNK1A1	1.60e-04	195	55	5	GO:0036064
GeneOntologyCellularComponent	protein complex involved in cell adhesion	LAMB2 ITGAE TNXB	5.05e-04	59	55	3	GO:0098636
GeneOntologyCellularComponent	beta-catenin destruction complex	CSNK1A1L CSNK1A1	5.20e-04	13	55	2	GO:0030877
GeneOntologyCellularComponent	protein complex involved in cell-matrix adhesion	LAMB2 TNXB	9.01e-04	17	55	2	GO:0098637
HumanPheno	Bilirubinuria	SLCO1B3 SLCO1B1	2.51e-05	2	26	2	HP:0031811
Domain	OA_transporter	SLCO1B3 SLCO1B1	5.72e-04	12	56	2	IPR004156
Domain	OATP	SLCO1B3 SLCO1B1	5.72e-04	12	56	2	PF03137
Domain	Chromodomain_CS	CHD1 CHD3	1.31e-03	18	56	2	IPR023779
Domain	-	VWA8 ERAL1 CHD1 ZNFX1 CHD3 CHST1 RRAD ABCD2	1.62e-03	746	56	8	3.40.50.300
Domain	Actinin_actin-bd_CS	DST UTRN	2.15e-03	23	56	2	IPR001589
Domain	Spectrin	DST UTRN	2.15e-03	23	56	2	PF00435
Domain	ACTININ_2	DST UTRN	2.15e-03	23	56	2	PS00020
Domain	ACTININ_1	DST UTRN	2.15e-03	23	56	2	PS00019
Domain	Chromo_domain	CHD1 CHD3	2.34e-03	24	56	2	IPR023780
Domain	Chromo	CHD1 CHD3	2.74e-03	26	56	2	PF00385
Domain	CHROMO_1	CHD1 CHD3	3.17e-03	28	56	2	PS00598
Domain	CHROMO_2	CHD1 CHD3	3.17e-03	28	56	2	PS50013
Domain	Spectrin_repeat	DST UTRN	3.40e-03	29	56	2	IPR002017
Domain	P-loop_NTPase	VWA8 ERAL1 CHD1 ZNFX1 CHD3 CHST1 RRAD ABCD2	3.59e-03	848	56	8	IPR027417
Domain	SNF2_N	CHD1 CHD3	4.13e-03	32	56	2	IPR000330
Domain	Spectrin/alpha-actinin	DST UTRN	4.13e-03	32	56	2	IPR018159
Domain	Chromodomain-like	CHD1 CHD3	4.13e-03	32	56	2	IPR016197
Domain	SNF2_N	CHD1 CHD3	4.13e-03	32	56	2	PF00176
Domain	SPEC	DST UTRN	4.13e-03	32	56	2	SM00150
Domain	Chromo/shadow_dom	CHD1 CHD3	4.39e-03	33	56	2	IPR000953
Domain	CHROMO	CHD1 CHD3	4.39e-03	33	56	2	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD1 CHD3	4.93e-03	35	56	2	IPR002464
Domain	Kazal_2	SLCO1B3 SLCO1B1	5.21e-03	36	56	2	PF07648
Domain	Protein_kinase_ATP_BS	CSNK1A1L CSNK1A1 MARK3 FER CDC42BPB	5.48e-03	379	56	5	IPR017441
Domain	Kinase-like_dom	CSNK1A1L DST CSNK1A1 MARK3 FER CDC42BPB	5.52e-03	542	56	6	IPR011009
Domain	DEAH_ATP_HELICASE	CHD1 CHD3	5.79e-03	38	56	2	PS00690
Domain	C2	RASA2 SYTL4 HECW2	7.13e-03	131	56	3	PF00168
Domain	C2	RASA2 SYTL4 HECW2	8.06e-03	137	56	3	SM00239
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	AGBL4 CSNK1A1L DST FN1 CSNK1A1 MARK3 HECW2 CORO1C ACTBL2 RPS15 ZNFX1 CHD3 UTRN CDC42BPB METAP2	5.06e-09	1431	56	15	37142655
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DIS3L2 DST FN1 RASA2 FBL ERAL1 CORO1C RPS15 UTP20 CHD1 UTRN METAP2 DPM1	1.75e-07	1353	56	13	29467282
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FOCAD SETDB1 DST FN1 ZNF532 CORO1C ZNFX1 GNPTG UTRN CDC42BPB METAP2 DPM1	7.62e-07	1285	56	12	35914814
Pubmed	Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.	CSNK1A1L FBL CSNK1A1 CHD3	2.08e-06	56	56	4	26919559
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	SETDB1 IFT140 DST VWA8 ZNFX1	2.21e-06	130	56	5	12421765
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	NEDD9 DST FBL CSNK1A1 MARK3 CORO1C RPS15 LAMB2 UTP20 DPM1	2.49e-06	949	56	10	36574265
Pubmed	Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	18314419
Pubmed	OATP 1B1/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	21691816
Pubmed	Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	28063966
Pubmed	Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	23354688
Pubmed	Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	22240838
Pubmed	Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	29944058
Pubmed	Tissue-specific distribution of mouse casein kinase I alpha mRNA.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	9522121
Pubmed	Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	25994086
Pubmed	Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	17412826
Pubmed	SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	36964102
Pubmed	CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	37723657
Pubmed	Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	36929849
Pubmed	Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	23340295
Pubmed	Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	29777022
Pubmed	Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	26191226
Pubmed	Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	22771883
Pubmed	Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	24194513
Pubmed	Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	18180273
Pubmed	Structure of human drug transporters OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	37723174
Pubmed	Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	35695793
Pubmed	Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	24855184
Pubmed	Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	26474710
Pubmed	Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	25578040
Pubmed	Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	23670789
Pubmed	Exploring the role of casein kinase 1α splice variants across cancer cell lines.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	38852281
Pubmed	Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	24989890
Pubmed	Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	17496208
Pubmed	Rotor Syndrome	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	23236639
Pubmed	Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing.	FBL UTP20	2.55e-06	2	56	2	17498821
Pubmed	Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	23690993
Pubmed	Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	27098745
Pubmed	Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	24740327
Pubmed	Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	21719246
Pubmed	Organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3: genetic variability and haplotype analysis in white Canadians.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	20877131
Pubmed	Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	34216174
Pubmed	Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	37108197
Pubmed	Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	16534140
Pubmed	UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	31299240
Pubmed	In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	23886114
Pubmed	OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	21787759
Pubmed	Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.	CSNK1A1L CSNK1A1	2.55e-06	2	56	2	36542875
Pubmed	Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	2.55e-06	2	56	2	18321482
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DST FBL ERAL1 CORO1C ACTBL2 LAMB2 UTP20 CHD1 CHD3 UTRN	4.88e-06	1024	56	10	24711643
Pubmed	Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	31047942
Pubmed	Expression of tenascin in developing and adult mouse lymphoid organs.	FN1 TNXB	7.63e-06	3	56	2	7687262
Pubmed	Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	26146841
Pubmed	Isolation and proteomic characterization of human Parvulin-associating preribosomal ribonucleoprotein complexes.	FN1 FBL	7.63e-06	3	56	2	11960984
Pubmed	SLCO1B1, SLCO2B1, and SLCO1B3 polymorphisms and susceptibility to bladder cancer risk.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	24762081
Pubmed	CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.	CSNK1A1L CSNK1A1	7.63e-06	3	56	2	28878021
Pubmed	Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.	CSNK1A1L CSNK1A1	7.63e-06	3	56	2	26811327
Pubmed	Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	18296417
Pubmed	Interaction Between Sex and Organic Anion-Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib-N-Oxide and Regorafenib-Glucuronide in Mice.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	30955241
Pubmed	Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	20660695
Pubmed	Influence of drug formulation on OATP1B-mediated transport of paclitaxel.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	24755470
Pubmed	Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.	CSNK1A1L CSNK1A1	7.63e-06	3	56	2	19805514
Pubmed	OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	29337310
Pubmed	Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	22136368
Pubmed	Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	31967785
Pubmed	Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	28013215
Pubmed	The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	19890249
Pubmed	Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.	CSNK1A1L CSNK1A1	7.63e-06	3	56	2	24616378
Pubmed	HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	20051929
Pubmed	Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	19620935
Pubmed	Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	29422623
Pubmed	Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	24825069
Pubmed	Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	22695893
Pubmed	Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	18492796
Pubmed	Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	28389619
Pubmed	Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.	CSNK1A1L CSNK1A1	7.63e-06	3	56	2	25242043
Pubmed	Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	26383540
Pubmed	Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	23986199
Pubmed	Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	18413659
Pubmed	Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.	CSNK1A1L CSNK1A1	7.63e-06	3	56	2	28655862
Pubmed	Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	22203093
Pubmed	Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	20949553
Pubmed	Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake of Glucuronide Metabolites of Androgens.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	32587096
Pubmed	Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	26409184
Pubmed	Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	19400585
Pubmed	Synergistic interaction between genetics and disease on pravastatin disposition.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	24613363
Pubmed	OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	30218633
Pubmed	Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	25391605
Pubmed	Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1).	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	10833452
Pubmed	Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.	SLCO1B3 SLCO1B1	7.63e-06	3	56	2	10779507
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	NEDD9 DST FN1 RPS15 RRAD UTRN CDC42BPB	1.48e-05	497	56	7	23414517
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	DST NT5C2 METAP2 DMXL1	1.52e-05	92	56	4	15840729
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	SLCO1B3 CHST1 ABCD2 SLCO1B1 NDUFS6	1.52e-05	193	56	5	19343046
Pubmed	Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain.	SLCO1B3 SLCO1B1	1.52e-05	4	56	2	22294745
Pubmed	Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.	CSNK1A1L CSNK1A1	1.52e-05	4	56	2	38147624
Pubmed	Characterization of the CHD family of proteins.	CHD1 CHD3	1.52e-05	4	56	2	9326634
Pubmed	Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.	SLCO1B3 SLCO1B1	1.52e-05	4	56	2	20644253
Pubmed	The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.	CSNK1A1L CSNK1A1	1.52e-05	4	56	2	32728212
Pubmed	Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.	SLCO1B3 SLCO1B1	1.52e-05	4	56	2	17906856
Pubmed	Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.	SLCO1B3 SLCO1B1	1.52e-05	4	56	2	21849517
Pubmed	Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.	SLCO1B3 SLCO1B1	1.52e-05	4	56	2	25280775
Cytoband	14q32.3	MARK3 CDC42BPB	6.54e-05	10	56	2	14q32.3
Cytoband	20q13.13	ZNFX1 DPM1	7.08e-04	32	56	2	20q13.13
Coexpression	LAKE_ADULT_KIDNEY_C29_UNKNOWN_NOVEL_PT_CFH_POS_SUBPOPULATION_S2	NEDD9 AGBL4 DST FER UTRN	1.03e-06	86	55	5	M39248
Coexpression	GSE43955_1H_VS_10H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN	TXNRD1 FN1 ZNF532 ITGAE DPM1 NDUFS6	3.89e-06	200	55	6	M9675
Coexpression	GSE13547_2H_VS_12_H_ANTI_IGM_STIM_ZFX_KO_BCELL_UP	NEDD9 DST CHD3 GNPTG DMXL1	2.66e-05	167	55	5	M2995
Coexpression	COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN	TXNRD1 FN1 CSNK1A1	2.76e-05	28	55	3	M14859
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	NEDD9 FAM111A RASA2 EMB MARK3 EPC1 RPS15 CHD1 ZNFX1 CHD3 ITGAE UTRN	4.95e-05	1492	55	12	M40023
Coexpression	GSE9037_CTRL_VS_LPS_1H_STIM_BMDM_UP	RASA2 SYTL4 SH3BP2 CHD1 CHD3	6.28e-05	200	55	5	M5800
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	FOCAD AGBL4 HECW2 KCNB2 CSMD3	5.25e-06	200	56	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	356C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	IFT140 ANK1 ZNFX1 GNPTG	6.06e-05	169	56	4	0425d2580ed325178f522c0093ff4623de6ce7a8
ToppCell	356C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	IFT140 ANK1 ZNFX1 GNPTG	6.06e-05	169	56	4	fec669968a77060bd77ee8695034e35a642c984f
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM111A FN1 SH3BP2 ABCD2	6.49e-05	172	56	4	e72966ced5f2ee9e24ce9fd820d99a69a482a607
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM111A FN1 SH3BP2 ABCD2	6.49e-05	172	56	4	83730ea3b240b8e2f2a9fb6c34dd1408050867ff
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMB CHD3 ITGAE UTRN	6.78e-05	174	56	4	919fc124affc69acfd8f575f2c372674f3d2625e
ToppCell	facs-Spleen-nan-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST EMB CHD3 UTRN	8.07e-05	182	56	4	fbe5bdd642b86010dbef0a567b25c69c7335688f
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	FN1 HECW2 UTRN TNXB	8.25e-05	183	56	4	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DST LAMB2 UTRN TNXB	8.25e-05	183	56	4	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	droplet-Spleen-nan-3m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS15 CHD3 UTRN DMXL1	8.78e-05	186	56	4	26f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCell	droplet-Spleen-nan-3m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS15 CHD3 UTRN DMXL1	8.96e-05	187	56	4	91c8e93bde0d1d1a4e324b0acf2afda00f4fb3bf
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMB RPS15 CHD3 UTRN	8.96e-05	187	56	4	1387981d224cb9e846ed18e366736855a4eb827e
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS15 CHD3 UTRN DMXL1	8.96e-05	187	56	4	382db691eb0b3e089e816bed3d6699cc2d4e1bda
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	DST FN1 KCNB2 TNXB	8.96e-05	187	56	4	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK1 FN1 UTRN TNXB	9.15e-05	188	56	4	a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCell	COPD-Myeloid-Macrophage_Alveolar\|COPD / Disease state, Lineage and Cell class	DST FN1 CORO1C CDC42BPB	9.53e-05	190	56	4	006e31606d637033bc81333816ee332773d36b08
ToppCell	droplet-Limb_Muscle\|droplet / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNRD1 FN1 RRAD TNXB	9.53e-05	190	56	4	06c2b13fa88abbcb8086f13b8d98a156e41e4198
ToppCell	COPD-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	DST FN1 CORO1C CDC42BPB	9.53e-05	190	56	4	9fc763d65470ba8858b973689c4d4358faab7dd3
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DST SYTL4 AASS METAP2	9.53e-05	190	56	4	799351fea7490d4159271d020c43c845ef37c788
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	DST FN1 VWA8 CDC42BPB	9.73e-05	191	56	4	a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNRD1 NEDD9 DST EMB	9.92e-05	192	56	4	c47df468cf78a90929913c9022e8078a53cdf680
ToppCell	droplet-Thymus-nan-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMB CSNK1A1 CHD1 METAP2	1.01e-04	193	56	4	81871f4f2b63ca5f64a9ff12f6c909a34bf52216
ToppCell	droplet-Thymus-nan-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMB CSNK1A1 CHD1 METAP2	1.01e-04	193	56	4	12380713db6582749183a19de65d4af9d6469a3f
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DST FN1 AASS TNXB	1.01e-04	193	56	4	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	DST FN1 CORO1C CDC42BPB	1.01e-04	193	56	4	03a43b6d235fd47488a6a61efc311a34b232c0f4
ToppCell	RA\|World / Chamber and Cluster_Paper	TXNRD1 AGBL4 FN1 CSNK1A1	1.03e-04	194	56	4	08f0afbb68a63150fbe107a5337299081c3f69e4
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNRD1 NEDD9 DST EMB	1.05e-04	195	56	4	f41a68b7c2621594db8d8952e301eeadc96be26f
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	NEDD9 SLC9C1 HECW2 UTRN	1.05e-04	195	56	4	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	10x3'2.3-week_14-16\|World / cell types per 3 fetal stages;per 3',per 5'	FBL RPS15 DPM1 NDUFS6	1.05e-04	195	56	4	1db4df62578761c1ad49427cd9963540c731f1f2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HECW2 UTRN TNXB	1.07e-04	196	56	4	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOCAD AGBL4 KCNB2 CSMD3	1.07e-04	196	56	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	3'_v3-Lung\|World / Manually curated celltypes from each tissue	DST FN1 CORO1C CDC42BPB	1.07e-04	196	56	4	a04f8384b734ce67ec402e64bd891a6274f04744
ToppCell	Epithelial_cells-AT1_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	NEDD9 DST FN1 LAMB2	1.07e-04	196	56	4	6c99d29162848161c1f166a032320f87a5d5a631
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HECW2 UTRN TNXB	1.07e-04	196	56	4	b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DST FN1 AASS TNXB	1.07e-04	196	56	4	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HECW2 UTRN TNXB	1.07e-04	196	56	4	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HECW2 UTRN TNXB	1.07e-04	196	56	4	145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HECW2 UTRN TNXB	1.07e-04	196	56	4	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNRD1 EMB CHD1 RRAD	1.10e-04	197	56	4	cfd4cc5fb8d7a60dd5c0d2a1a7bad7ba38c19d40
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DST FN1 KCNB2 TNXB	1.10e-04	197	56	4	6d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HECW2 UTRN TNXB	1.12e-04	198	56	4	953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HECW2 UTRN TNXB	1.12e-04	198	56	4	8e45551224fbb30c0658ad47dd98335ecf165437
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AGBL4 HECW2 KCNB2 CSMD3	1.12e-04	198	56	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DST FN1 AASS TNXB	1.12e-04	198	56	4	f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DST FN1 LAMB2 TNXB	1.14e-04	199	56	4	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST FN1 SYTL4 TNXB	1.14e-04	199	56	4	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	3'_v3-Lung-Myeloid_Mac\|Lung / Manually curated celltypes from each tissue	DST FN1 CORO1C CDC42BPB	1.14e-04	199	56	4	1677aaee5b7f5f262e27df5d9f1bdf6e21e3d804
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	FOCAD VWA8 FER UTRN	1.14e-04	199	56	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DST FN1 SYTL4 TNXB	1.14e-04	199	56	4	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DST FN1 AASS TNXB	1.14e-04	199	56	4	66a79732caf2f04c09b4d9832377aa01ca477677
ToppCell	3'_v3-Lung-Myeloid_Mac-Alveolar_macrophages\|Lung / Manually curated celltypes from each tissue	DST FN1 CORO1C CDC42BPB	1.14e-04	199	56	4	eec1b086e5e8b9b0e1770dd269ca903f713d99a8
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DST FN1 SYTL4 TNXB	1.16e-04	200	56	4	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	10x5'-Lung-Myeloid_Mac-Alveolar_macrophages\|Lung / Manually curated celltypes from each tissue	DST FN1 CORO1C CDC42BPB	1.16e-04	200	56	4	3b236900df407bf5a8c44e76d003a7a37d251db6
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ANK1 SYTL4 LAMB2 RRAD	1.16e-04	200	56	4	aafe594c88710f8c53d59667cdac5035e08f5511
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HECW2 UTRN TNXB	1.16e-04	200	56	4	dba96cda5f3b780a3d4171b61bc8aaddc1f5d466
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DST FN1 SYTL4 TNXB	1.16e-04	200	56	4	44a68bacdb3d5bf563bd35952176995850933a81
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RASA2 EMB ABCD2 ITGAE	1.16e-04	200	56	4	02c4169a23e5aaa0d4bfc78b51ba19ce8157dc3e
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	EMB EPC1 CHD1 UTRN	1.16e-04	200	56	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ANK1 SYTL4 LAMB2 RRAD	1.16e-04	200	56	4	a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DST FN1 SYTL4 TNXB	1.16e-04	200	56	4	dc61016c61729f69649cfb21f6264e685ce83dea
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-gdT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RASA2 EMB ABCD2 ITGAE	1.16e-04	200	56	4	9996803c35444d32b76ab78b716674c3743f155a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 HECW2 UTRN TNXB	1.16e-04	200	56	4	7a69ad5b6c84f1aebacea5cacb9bc5c63dfd1dac
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	DST FN1 SYTL4 TNXB	1.16e-04	200	56	4	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-3\|TCGA-Breast / Sample_Type by Project: Shred V9	DST ACTBL2 SLCO1B3	6.80e-04	137	56	3	3218c787a6b087f74b0804cec14b5ebb713391b7
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CSNK1A1L CORO1C TTC23L	6.80e-04	137	56	3	264d5e06c37d1a9ef7748091b67d2a5aa803096e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related-Oligodendrocyte/OPC\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CSNK1A1L CORO1C TTC23L	6.80e-04	137	56	3	8ce463d1d74ac0ce80b812217d6bd76a788f14d2
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_B1-4\|TCGA-Thymus / Sample_Type by Project: Shred V9	SLC9C1 DIS3L2 CORO1C	7.24e-04	140	56	3	21e5f55a98b819d3638ec971d5029b2fcbd1ebc7
ToppCell	COVID-19_Mild-Neu_2\|World / 5 Neutrophil clusters in COVID-19 patients	IFT140 FER CDC42BPB	7.24e-04	140	56	3	b1429028c52f84127b894b93b55961badcd5246f
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9C1 ACTBL2 CSMD3	8.02e-04	145	56	3	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	AGBL4 CHST1 CSMD3	8.68e-04	149	56	3	c5eedb54ef2e0f131aa6730612c921bc19479632
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	AGBL4 CHST1 CSMD3	8.68e-04	149	56	3	a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCell	E17.5-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ANK1 MARK3 KCNB2	8.85e-04	150	56	3	201d5b68e71c6c003285428be96c488e6d526edf
ToppCell	facs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEDD9 FN1 EMB	9.37e-04	153	56	3	0ef7c45cdd854c79e527006034029767f8e108b2
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4\|GI_small-bowel / Manually curated celltypes from each tissue	SLC9C1 ANK1 RPS15	9.91e-04	156	56	3	e308328f560c5ee7e9f95ac5db162f2d821ca39c
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AGBL4 DIS3L2 ITGAE	9.91e-04	156	56	3	af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM111A EMB DPM1	1.01e-03	157	56	3	904cd98ae85ed6459e0663f077ac462842bf12df
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM111A EMB FBL	1.01e-03	157	56	3	552fd5d09bbe81f58404ec38166feb30fc84def5
ToppCell	facs-Liver\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 AASS SLCO1B3	1.03e-03	158	56	3	ea7db6bd9742153ceb6e444892a6d1df9c7fcc96
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EMB CHST1 ABCD2	1.05e-03	159	56	3	0c2437da5443fc3aff66f8ef311f02aa434a1fb0
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAM111A EMB NT5C2	1.05e-03	159	56	3	999f30c7273ed77b34537621bcfcc7fc30121138
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANK1 ST8SIA2 SP9	1.05e-03	159	56	3	c64fff8d89f84d1f5a0cc432e31f56f741162505
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 EMB ABCD2	1.05e-03	159	56	3	709b57f992a29878cc899d760d144d36cb5cb280
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 AASS SLCO1B3	1.07e-03	160	56	3	8de1fc75241d9bf2b355afa0e9ef39fea1977177
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 FN1 CHST1	1.07e-03	160	56	3	56e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 FN1 CHST1	1.07e-03	160	56	3	bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9C1 FN1 CSMD3	1.08e-03	161	56	3	b9a17f41426bf715f30bf544a6795afaf37a3aa6
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9C1 FN1 CSMD3	1.08e-03	161	56	3	f7a89c481f789f624102857be722c95fbeb47595
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMB SLCO1B3 RRAD	1.08e-03	161	56	3	b9a63fc9becc44d305fc7c221283bf59ec06b10f
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 FN1 CHST1	1.08e-03	161	56	3	60f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMB CHD3 RRAD	1.10e-03	162	56	3	58fe827198c172eeaa26273b0fad7991a718b0bf
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 AASS SLCO1B3	1.12e-03	163	56	3	03d9fa615d9d02ef98e20f28a10aaa6894dd4960
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 AASS SLCO1B3	1.12e-03	163	56	3	1c4de36cf8cdaabb981cda5c7ce7e5ae7b4280e3
ToppCell	facs-Marrow-T-cells-24m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFT140 ANK1 CHST1	1.12e-03	163	56	3	c1e9c3b05d407b4dff1cd53de688b43b61128ad0
ToppCell	droplet-Liver-Hepatocytes-18m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 AASS SLCO1B3	1.12e-03	163	56	3	7e82c1b7849eca895732df2da74ac6430bd9ba7a
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-Activated_CD8_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RASA2 ABCD2 ITGAE	1.14e-03	164	56	3	24fdea5113d92b96f56b06dd2449910a3c785e69
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DIS3L2 CSNK1A1L SYTL4	1.16e-03	165	56	3	436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DIS3L2 CSNK1A1L SYTL4	1.16e-03	165	56	3	242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANK1 ST8SIA2 SP9	1.16e-03	165	56	3	d8df50f5a3b646e8ea13739fdc65ce6f39b4d4d2
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM111A SH3BP2 ABCD2	1.16e-03	165	56	3	1dcd6b8aa192baeaa1f7bb334843edab6049b96f
ToppCell	facs-Marrow-B-cells-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 CHST1 RRAD	1.16e-03	165	56	3	361a605d8f833d9ec54b120480dce397da35f9c3
Drug	AC1MVZ0B	DST FN1 EMB SLCO1B3	5.89e-06	48	56	4	CID003691183
Drug	(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid	SLCO1B3 SLCO1B1	5.94e-06	2	56	2	ctd:C561635
Drug	kalinin	NEDD9 DST FN1 LAMB2	1.02e-05	55	56	4	CID000032518
Drug	Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate	TXNRD1 AASS	1.78e-05	3	56	2	DB02338
Drug	DMSe	DST FN1 FBL CHD1 TNXB	1.83e-05	132	56	5	CID000020796
Drug	2,3-dihydroxybenzaldehyde	DST RASA2 RPS15 RRAD	3.15e-05	73	56	4	CID000090579
Drug	kaempferol	FN1 LAMB2 SLCO1B3 SLCO1B1 UTRN	3.28e-05	149	56	5	ctd:C006552
Drug	rifamycin SV	SLCO1B3 SLCO1B1	3.55e-05	4	56	2	ctd:C023808
Drug	microcystin-LF	SLCO1B3 SLCO1B1	3.55e-05	4	56	2	ctd:C524165
Drug	Dihydromicrocystin Lr	SLCO1B3 SLCO1B1	3.55e-05	4	56	2	CID006441227
Drug	AC1L9LMC	DST LAMB2 CHD1 UTRN	5.22e-05	83	56	4	CID000448113
Drug	2,2',4,4',5,6'-hexabromodiphenyl ether	SLCO1B3 SLCO1B1	5.91e-05	5	56	2	ctd:C555859
Drug	d 29-32	FER CHD3 TNXB	7.30e-05	33	56	3	CID000010743
Drug	Bq123	FN1 MARK3 ST8SIA2 SLCO1B1	8.85e-05	95	56	4	CID000443289
Drug	trospium chloride	SLCO1B3 SLCO1B1	8.86e-05	6	56	2	ctd:C003330
Drug	prednisolone phosphate	SLCO1B3 SLCO1B1	8.86e-05	6	56	2	CID000004896
Disease	coronary artery disease	NEDD9 IFT140 FN1 EMB MARK3 CORO1C FER NT5C2 LAMB2 KCNB2 TNXB DMXL1	1.96e-06	1194	56	12	EFO_0001645
Disease	Rotor syndrome	SLCO1B3 SLCO1B1	3.54e-06	2	56	2	cv:C0220991
Disease	HYPERBILIRUBINEMIA, ROTOR TYPE, DIGENIC	SLCO1B3 SLCO1B1	3.54e-06	2	56	2	C4016905
Disease	HYPERBILIRUBINEMIA, ROTOR TYPE	SLCO1B3 SLCO1B1	3.54e-06	2	56	2	237450
Disease	Rotor Syndrome	SLCO1B3 SLCO1B1	3.54e-06	2	56	2	C0220991
Disease	bilirubin metabolic disorder (implicated_via_orthology)	SLCO1B3 SLCO1B1	3.52e-05	5	56	2	DOID:2741 (implicated_via_orthology)
Disease	Colorectal Carcinoma	TXNRD1 CSNK1A1L FN1 SLCO1B3 CHD1 KCNB2 ABCD2 CSMD3	5.11e-05	702	56	8	C0009402
Disease	bilirubin metabolic disorder (is_implicated_in)	SLCO1B3 SLCO1B1	5.28e-05	6	56	2	DOID:2741 (is_implicated_in)
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1A1L CSNK1A1	7.38e-05	7	56	2	DOID:0060807 (implicated_via_orthology)
Disease	deoxycholic acid glucuronide measurement	SLCO1B3 SLCO1B1	9.83e-05	8	56	2	EFO_0800575
Disease	hexadecenedioate (C16:1-DC) measurement	SLCO1B3 SLCO1B1	1.26e-04	9	56	2	EFO_0800562
Disease	X-21467 measurement	SLCO1B3 SLCO1B1	1.26e-04	9	56	2	EFO_0020007
Disease	mean corpuscular hemoglobin concentration	FOCAD IFT140 ANK1 MARK3 ERAL1 HECW2 NT5C2 SLCO1B1 DMXL1	2.18e-04	1105	56	9	EFO_0004528
Disease	glycochenodeoxycholate glucuronide (1) measurement	SLCO1B3 SLCO1B1	2.72e-04	13	56	2	EFO_0800474
Disease	reticulocyte measurement	ANK1 RASA2 VWA8 ERAL1 CORO1C NT5C2 SLCO1B1 METAP2	7.96e-04	1053	56	8	EFO_0010700
Disease	smoking status measurement	FOCAD AGBL4 HECW2 SH3BP2 NT5C2 CHD3 UTRN CDC42BPB	1.48e-03	1160	56	8	EFO_0006527
Disease	insomnia measurement	NT5C2 CHST1 KCNB2 CSMD3 METAP2	1.52e-03	443	56	5	EFO_0007876
Disease	smoking behavior, body mass index	AGBL4 RASA2 NT5C2	1.67e-03	123	56	3	EFO_0004318, EFO_0004340

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVLPASGVYKGLHLS	EPC1	686	Q9H2F5
GILTKRKGTILSPGY	CSMD3	1941	Q7Z407
GKKVITPVRTGHGYV	NEDD9	151	Q14511
LYPIIGKRLKQSGHG	ABCD2	36	Q9UBJ2
KLKIGTYTGPLQHGI	NT5C2	311	P49902
SKRGVLTLKYPIEHG	ACTBL2	61	Q562R1
AHLINYGTKGKVRLP	ANK1	161	P16157
YGTKGKVRLPALHIA	ANK1	166	P16157
PLAPKHIKGITNLGY	AASS	41	Q9UDR5
GYLHKKGGTQLQLLK	SH3BP2	31	P78314
ILISLKHGYIPGKNR	CORO1C	386	Q9ULV4
LKYSAILKRPGTQGH	DIS3L2	851	Q8IYB7
KIPVTIITGYLGAGK	CBWD5	41	Q5RIA9
LKKQPSYIGGHEGLE	CHD1	466	O14646
LGYPGGKARIIHKES	DMXL1	2626	Q9Y485
PREKKLGLGTAYIHG	DPM1	91	O60762
KIVGGHYLKVTLKPI	RASA2	411	Q15283
VYKVLLLGAPGVGKS	RRAD	91	P55042
TKGYGQGPGKLKLII	HECW2	1206	Q9P2P5
YRIHAGKTVPIVKGG	METAP2	336	P50579
IQGSKLRLPGYLSGK	DST	7446	Q03001
KIPVTIITGYLGAGK	CBWD2	41	Q8IUF1
KIPVTIITGYLGAGK	CBWD1	41	Q9BRT8
KYHSLPIIIKGSVGG	ITGAE	1121	P38570
YVKLLIGPKGHVISQ	ERAL1	396	O75616
GGALGHPKVYINLDK	NDUFS6	91	O75380
HIKPGAKVLYLGAAS	FBL	156	P22087
GISYKLHLKLVRTGG	LAMB2	686	P55268
SKLYTILQGGVGIPH	CSNK1A1L	61	Q8N752
QRGIGTAYKGHVKVP	CDC42BPB	1091	Q9Y5S2
LYTTHGLIKGPLSKV	CCDC105	371	Q8IYK2
IKRLKGLLTQHGIPY	GNPTG	256	Q9UJJ9
DIYPKTLLGKIVGGL	KCNB2	386	Q92953
GGVYSSSGLKQIPIK	FER	711	P16591
GHLNSYTIKGLKPGV	FN1	661	P02751
GYKIDHKLLLTGTPL	CHD3	901	Q12873
SGLIHIIGHPYGEKK	FAM111A	466	Q96PZ2
KIPVTIITGYLGAGK	CBWD3	41	Q5JTY5
KIPVTIITGYLGAGK	CBWD6	41	Q4V339
LPTGYCGQPKKGHLI	AGBL4	31	Q5VU57
PHIGNYRLLKTIGKG	MARK3	51	P27448
LHGKNKPLISYVGDS	EMB	161	Q6PCB8
GRVQGTPLLKHEYGK	IFT140	136	Q96RY7
YTLPKLGVHKVCIGQ	FOCAD	511	Q5VW36
ITILKRHTGKGYQKP	OR5B17	221	Q8NGF7
GLPSHKGELVVSLKY	SYTL4	491	Q96C24
YLILVKHGSGTKIPT	UTP20	326	O75691
GQPGHAYLETLKTLK	UTRN	906	P46939
KHKSYLTPGLIGSVG	SLC9C1	1111	Q4G0N8
SKLYKILQGGVGIPH	CSNK1A1	61	P48729
SVLKGTLKPGDIIHY	ST8SIA2	111	Q92186
YFGSKLHRPKLIGIG	SLCO1B1	86	Q9Y6L6
IPGCGKVYGKTSHLK	SP9	336	P0CG40
GTLIAIQTVGPGKKY	SETDB1	216	Q15047
TRGDPTLGKHKYGTV	CHST1	336	O43916
ITYKPVKHGRPGIGA	RPS15	121	P62841
KQRKIGGHGPTLKAY	TXNRD1	126	Q16881
TQHPGIKIGEPKIIY	ZNF532	891	Q9HCE3
YFGSKLHRPKLIGIG	SLCO1B3	86	Q9NPD5
LYGLLGKKRHGPLTA	TNXB	1741	P22105
GYLTLRGLPVQAKKH	TTC23L	121	Q6PF05
PGTGKTYVGLKIVQA	ZNFX1	621	Q9P2E3
LINTLHKYGIPIGAK	VWA8	1016	A3KMH1