Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncell adhesion molecule binding

FLNA DSCAM PTPRM TLN2 PLEC CDH4 TNXB DSCAML1 GFRA1 CDH18

8.80e-055997610GO:0050839
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

CELSR3 CELSR2 DSCAM PTPRM PECAM1 CDH4 DSCAML1 CDH18

3.95e-07187758GO:0007156
GeneOntologyBiologicalProcesscentral nervous system development

KRAS PLXNA3 FLNA DLG5 ABR CELSR2 DSCAM PLXNA4 KDM2B LRP5 DAAM2 ZNF76 TAF1 ATXN1L DSCAML1 NDUFS3

4.97e-0611977516GO:0007417
GeneOntologyBiologicalProcessaxon guidance

PLXNA3 CELSR3 DSCAM PTPRM PLXNA4 KIF5A CDH4 DSCAML1

9.12e-06285758GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

PLXNA3 CELSR3 DSCAM PTPRM PLXNA4 KIF5A CDH4 DSCAML1

9.35e-06286758GO:0097485
GeneOntologyBiologicalProcessanimal organ morphogenesis

KRAS FLNA IFT140 DLG5 ABR DSCAM PTPRM HRAS PDX1 KDM2B LRP5 TNNI1 DSCAML1 WNK4 BSX DNAH11

1.04e-0512697516GO:0009887
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

CELSR3 CELSR2 DSCAM PTPRM PECAM1 CDH4 DSCAML1 CDH18

1.80e-05313758GO:0098742
GeneOntologyBiologicalProcesscell-cell adhesion

FLNA DLG5 CELSR3 CELSR2 DSCAM PTPRM PECAM1 SHB LRP5 TLN2 CDH4 TNXB DSCAML1 CDH18

2.91e-0510777514GO:0098609
GeneOntologyBiologicalProcessregulation of phosphorylation

KRAS ARR3 NRAS CELSR3 DSCAM PECAM1 SHB CD109 HRAS LRP5 PLEC TNXB GFRA1 WNK4 XRCC6

2.93e-0512267515GO:0042325
GeneOntologyBiologicalProcessregulation of axon extension involved in axon guidance

PLXNA3 DSCAM PLXNA4

3.03e-0517753GO:0048841
GeneOntologyBiologicalProcesscell-cell junction organization

FLNA DLG5 PECAM1 TLN2 PLEC CDH4 CDH18

3.14e-05246757GO:0045216
GeneOntologyBiologicalProcessregulation of protein phosphorylation

KRAS ARR3 NRAS CELSR3 PECAM1 SHB CD109 HRAS LRP5 PLEC TNXB GFRA1 WNK4 XRCC6

5.07e-0511337514GO:0001932
GeneOntologyBiologicalProcessbrain development

KRAS PLXNA3 FLNA DLG5 ABR CELSR2 PLXNA4 KDM2B TAF1 ATXN1L DSCAML1 NDUFS3

5.88e-058597512GO:0007420
GeneOntologyBiologicalProcessaxon extension involved in axon guidance

PLXNA3 DSCAM PLXNA4

6.77e-0522753GO:0048846
GeneOntologyBiologicalProcessneuron projection extension involved in neuron projection guidance

PLXNA3 DSCAM PLXNA4

6.77e-0522753GO:1902284
GeneOntologyBiologicalProcessadherens junction organization

DLG5 PLEC CDH4 CDH18

7.19e-0561754GO:0034332
GeneOntologyBiologicalProcesscytokine precursor processing

PCSK5 FURIN

7.79e-054752GO:0140447
GeneOntologyBiologicalProcessprotein localization to cell-cell junction

FLNA DLG5 PECAM1

8.85e-0524753GO:0150105
GeneOntologyBiologicalProcesshead development

KRAS PLXNA3 FLNA DLG5 ABR CELSR2 PLXNA4 KDM2B TAF1 ATXN1L DSCAML1 NDUFS3

1.12e-049197512GO:0060322
GeneOntologyBiologicalProcesstube development

KRAS PCSK5 FLNA IFT140 DLG5 NRAS PTPRM PECAM1 SHB PLXNA4 PDX1 KDM2B LRP5 ATXN1L WNK4

1.34e-0414027515GO:0035295
GeneOntologyBiologicalProcessactin cytoskeleton organization

KRAS FLNA ABR PECAM1 HRAS CASP4 DAAM2 TLN2 MICAL3 PLEC TNXB

1.46e-048037511GO:0030036
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

KRAS ARR3 NRAS CELSR3 DSCAM PECAM1 SHB CD109 HRAS LRP5 PLEC TNXB GFRA1 WNK4 XRCC6

1.56e-0414217515GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

KRAS ARR3 NRAS CELSR3 DSCAM PECAM1 SHB CD109 HRAS LRP5 PLEC TNXB GFRA1 WNK4 XRCC6

1.58e-0414237515GO:0051174
GeneOntologyBiologicalProcesstrigeminal nerve morphogenesis

PLXNA3 PLXNA4

1.94e-046752GO:0021636
GeneOntologyBiologicalProcesstrigeminal nerve structural organization

PLXNA3 PLXNA4

1.94e-046752GO:0021637
GeneOntologyBiologicalProcessprotein localization to cell junction

FLNA DLG5 PECAM1 HRAS KIF5A

2.05e-04148755GO:1902414
GeneOntologyBiologicalProcessregulation of protein modification process

KRAS ARR3 NRAS CELSR3 PECAM1 SHB CD109 HRAS LRP5 TAF1 PLEC TNXB GFRA1 WNK4 XRCC6

2.58e-0414887515GO:0031399
GeneOntologyBiologicalProcessregulation of locomotion

PCSK5 PLXNA3 FLNA DLG5 EPPK1 ABR DSCAM PTPRM FURIN PECAM1 HRAS PLXNA4 DAAM2 TNXB

2.69e-0413277514GO:0040012
GeneOntologyBiologicalProcessbranchiomotor neuron axon guidance

PLXNA3 PLXNA4

2.71e-047752GO:0021785
GeneOntologyBiologicalProcesscell morphogenesis

PLXNA3 FLNA CELSR3 CELSR2 DSCAM PTPRM PECAM1 PLXNA4 KIF5A PLEC CDH4 DSCAML1 CDH18

3.39e-0411947513GO:0000902
GeneOntologyBiologicalProcessregionalization

PCSK5 IFT140 CELSR2 KDM2B LRP5 DAAM2 DSCAML1 DNAH11

3.40e-04478758GO:0003002
GeneOntologyBiologicalProcesscell-cell junction assembly

DLG5 PECAM1 TLN2 CDH4 CDH18

3.58e-04167755GO:0007043
GeneOntologyBiologicalProcessprotein-containing complex remodeling

PCSK5 TAF8 FURIN

3.84e-0439753GO:0034367
GeneOntologyBiologicalProcessregulation of cell migration

PCSK5 PLXNA3 FLNA DLG5 EPPK1 ABR PTPRM FURIN PECAM1 HRAS PLXNA4 DAAM2 TNXB

3.88e-0412117513GO:0030334
GeneOntologyBiologicalProcessmidbrain development

DLG5 KDM2B TAF1 NDUFS3

4.33e-0497754GO:0030901
GeneOntologyBiologicalProcessactin filament-based process

KRAS FLNA ABR PECAM1 HRAS CASP4 DAAM2 TLN2 MICAL3 PLEC TNXB

4.37e-049127511GO:0030029
GeneOntologyBiologicalProcessaxon development

PLXNA3 FLNA CELSR3 DSCAM PTPRM PLXNA4 KIF5A CDH4 DSCAML1

5.22e-04642759GO:0061564
GeneOntologyBiologicalProcessregulation of axon extension

PLXNA3 DSCAM PLXNA4 CDH4

5.63e-04104754GO:0030516
GeneOntologyBiologicalProcessfacial nerve structural organization

PLXNA3 PLXNA4

5.76e-0410752GO:0021612
GeneOntologyBiologicalProcesspattern specification process

PCSK5 IFT140 CELSR2 KDM2B LRP5 DAAM2 DSCAML1 DNAH11

6.39e-04526758GO:0007389
GeneOntologyBiologicalProcessregulation of cell motility

PCSK5 PLXNA3 FLNA DLG5 EPPK1 ABR PTPRM FURIN PECAM1 HRAS PLXNA4 DAAM2 TNXB

6.56e-0412807513GO:2000145
GeneOntologyBiologicalProcessneuron projection development

PLXNA3 FLNA DLG5 CELSR3 CELSR2 DSCAM PTPRM PLXNA4 KIF5A CDH4 TNXB DSCAML1 GFRA1

6.81e-0412857513GO:0031175
GeneOntologyBiologicalProcessneuron development

PLXNA3 FLNA IFT140 DLG5 CELSR3 CELSR2 DSCAM PTPRM PLXNA4 KIF5A CDH4 TNXB DSCAML1 GFRA1

7.17e-0414637514GO:0048666
GeneOntologyBiologicalProcesspositive regulation of axonogenesis

PLXNA3 DSCAM PLXNA4 CDH4

7.95e-04114754GO:0050772
GeneOntologyBiologicalProcesspositive regulation of nervous system development

KRAS PLXNA3 DLG5 DSCAM PLXNA4 CDH4 XRCC6

8.10e-04418757GO:0051962
GeneOntologyBiologicalProcessfacial nerve morphogenesis

PLXNA3 PLXNA4

8.41e-0412752GO:0021610
GeneOntologyBiologicalProcessfacial nerve development

PLXNA3 PLXNA4

8.41e-0412752GO:0021561
GeneOntologyBiologicalProcessmRNA transcription by RNA polymerase II

FLNA TAF8 TAF1

8.98e-0452753GO:0042789
GeneOntologyBiologicalProcesssemaphorin-plexin signaling pathway

PLXNA3 FLNA PLXNA4

8.98e-0452753GO:0071526
GeneOntologyBiologicalProcesscranial nerve structural organization

PLXNA3 PLXNA4

9.92e-0413752GO:0021604
GeneOntologyBiologicalProcesstrigeminal nerve development

PLXNA3 PLXNA4

9.92e-0413752GO:0021559
GeneOntologyBiologicalProcessregulation of extent of cell growth

PLXNA3 DSCAM PLXNA4 CDH4

1.02e-03122754GO:0061387
GeneOntologyBiologicalProcessaxonogenesis

PLXNA3 CELSR3 DSCAM PTPRM PLXNA4 KIF5A CDH4 DSCAML1

1.03e-03566758GO:0007409
GeneOntologyBiologicalProcesspositive regulation of integrin-mediated signaling pathway

PCSK5 FLNA

1.15e-0314752GO:2001046
GeneOntologyBiologicalProcesssignal peptide processing

PCSK5 FURIN

1.15e-0314752GO:0006465
GeneOntologyBiologicalProcessmRNA transcription

FLNA TAF8 TAF1

1.17e-0357753GO:0009299
GeneOntologyBiologicalProcessneuron recognition

CELSR3 DSCAM DSCAML1

1.30e-0359753GO:0008038
GeneOntologyBiologicalProcessmotor neuron migration

CELSR3 CELSR2

1.33e-0315752GO:0097475
GeneOntologyCellularComponentanchoring junction

KRAS FLNA DLG5 EPPK1 PTPRM PECAM1 ANO7 TLN2 PLEC CDH4 WNK4 CDH18

1.52e-049767412GO:0070161
GeneOntologyCellularComponentcell-cell junction

FLNA DLG5 EPPK1 PTPRM PECAM1 TLN2 CDH4 WNK4 CDH18

2.34e-04591749GO:0005911
HumanPhenoLinear nevus sebaceous

KRAS NRAS HRAS

6.99e-083223HP:0010817
HumanPhenoNevus sebaceous

KRAS NRAS HRAS

6.96e-075223HP:0010815
HumanPhenoEpidermal nevus

KRAS NRAS HRAS

1.50e-0512223HP:0010816
HumanPhenoAbnormal metatarsal ossification

FLNA LRP5

1.78e-052222HP:0008371
HumanPhenoHemimegalencephaly

KRAS NRAS HRAS

2.47e-0514223HP:0007206
HumanPhenoCranial asymmetry

KRAS NRAS HRAS

4.57e-0517223HP:0000267
HumanPhenoVertebral segmentation defect

KRAS GDF5 FLNA NRAS HRAS TAF1

4.61e-05162226HP:0003422
HumanPhenoNevus spilus

NRAS HRAS

5.33e-053222HP:0025510
HumanPhenoSubcutaneous hemorrhage

KRAS FLNA NRAS NFKB2 CD109 PLEC TNXB

6.98e-05258227HP:0001933
HumanPhenoDeviation of the 2nd finger

GDF5 FLNA IFT140

7.60e-0520223HP:0009468
HumanPhenoArachnoid cyst

KRAS IFT140 NRAS HRAS

9.50e-0558224HP:0100702
HumanPhenoAbnormal arachnoid mater morphology

KRAS IFT140 NRAS HRAS

1.02e-0459224HP:0100700
HumanPhenoRenal cortical hyperechogenicity

DLG5 DAAM2

1.06e-044222HP:0033132
HumanPhenoAbnormality of blood circulation

KRAS FLNA NRAS NFKB2 CD109 PDX1 LRP5 PLEC TNXB

1.18e-04498229HP:0011028
HumanPhenoAbnormal shape of the occiput

KRAS FLNA NRAS HRAS TAF1

1.23e-04119225HP:0011217
HumanPhenoProminent occiput

KRAS FLNA NRAS HRAS

1.24e-0462224HP:0000269
HumanPhenoAbnormal occipital bone morphology

KRAS FLNA NRAS HRAS TAF1

1.33e-04121225HP:0012294
HumanPhenoKyphoscoliosis

KRAS FLNA NRAS HRAS LRP5 NDUFS3

1.34e-04196226HP:0002751
HumanPhenoMitral valve prolapse

KRAS FLNA IFT140 HRAS TNXB

1.43e-04123225HP:0001634
HumanPhenoHemihypertrophy

KRAS NRAS HRAS

1.51e-0425223HP:0001528
HumanPhenoAdenoma sebaceum

KRAS NRAS HRAS

1.51e-0425223HP:0009720
HumanPhenoHypophosphatemic rickets

KRAS NRAS HRAS

1.51e-0425223HP:0004912
HumanPhenoAplasia/Hypoplasia of the skin

KRAS FLNA IFT140 TAF1 PLEC TNXB

1.54e-04201226HP:0008065
HumanPhenoAbnormal urinary electrolyte concentration

KRAS IFT140 DLG5 NRAS HRAS

1.61e-04126225HP:0012591
HumanPhenoBilateral ptosis

FLNA NRAS PDX1 PLEC

1.88e-0469224HP:0001488
HumanPhenoAbnormal posterior cranial fossa morphology

KRAS FLNA TAF8 NRAS HRAS KIF5A

2.59e-04221226HP:0000932
HumanPhenoAngiofibromas

KRAS NRAS HRAS

2.63e-0430223HP:0010615
HumanPhenoHyperphosphaturia

KRAS NRAS HRAS

2.63e-0430223HP:0003109
HumanPhenoRadial deviation of the 2nd finger

GDF5 FLNA

2.64e-046222HP:0009467
HumanPhenoAbnormal lymphocyte apoptosis

KRAS NRAS

2.64e-046222HP:0030886
HumanPhenoNon-medullary thyroid carcinoma

NRAS HRAS

2.64e-046222HP:0040198
HumanPhenoDecreased lymphocyte apoptosis

KRAS NRAS

2.64e-046222HP:0002731
HumanPhenoLymphedema

KRAS NRAS HRAS LRP5

2.73e-0476224HP:0001004
HumanPhenoCone-shaped epiphyses of the phalanges of the hand

GDF5 FLNA IFT140

2.91e-0431223HP:0010230
HumanPhenoCavernous hemangioma

KRAS NRAS HRAS

2.91e-0431223HP:0001048
HumanPhenoTransitional cell carcinoma of the bladder

KRAS NRAS HRAS

2.91e-0431223HP:0006740
HumanPhenoPorencephalic cyst

KRAS NRAS HRAS

3.20e-0432223HP:0002132
HumanPhenoPhalangeal cone-shaped epiphyses

GDF5 FLNA IFT140

3.20e-0432223HP:0034281
HumanPhenoAbnormal mitral valve morphology

KRAS FLNA IFT140 HRAS TNXB

3.21e-04146225HP:0031477
HumanPhenoAbnormal morphology of the vestibule of the inner ear

KRAS NRAS HRAS

3.51e-0433223HP:0011376
HumanPhenoBladder carcinoma

KRAS NRAS HRAS

3.51e-0433223HP:0002862
HumanPhenoFacial asymmetry

KRAS GDF5 FLNA NRAS HRAS

3.52e-04149225HP:0000324
HumanPhenoCongenital giant melanocytic nevus

NRAS HRAS

3.69e-047222HP:0005600
HumanPhenoProminence of the premaxilla

NRAS HRAS

3.69e-047222HP:0010759
HumanPhenoFull cheeks

KRAS FLNA IFT140 NRAS HRAS

3.75e-04151225HP:0000293
HumanPhenoGenu recurvatum

KRAS NRAS HRAS

3.84e-0434223HP:0002816
HumanPhenoAbnormality of dental color

KRAS NRAS HRAS

3.84e-0434223HP:0011073
HumanPhenoBladder neoplasm

KRAS NRAS HRAS

3.84e-0434223HP:0009725
HumanPhenoCongenital onset

KRAS GDF5 FLNA IFT140 DLG5 NRAS HRAS PDX1 LRP5 KIF5A TAF1 PLEC GFRA1

3.85e-0412062213HP:0003577
HumanPhenoAbnormal urine phosphate concentration

KRAS NRAS HRAS

4.19e-0435223HP:0012599
HumanPhenoAbnormal skull base morphology

KRAS FLNA TAF8 NRAS HRAS KIF5A

4.24e-04242226HP:0002693
HumanPhenoCurly hair

KRAS NRAS HRAS

4.55e-0436223HP:0002212
HumanPhenoOvergrowth

KRAS NRAS HRAS PDX1

4.59e-0487224HP:0001548
HumanPhenoAbnormal knee physiology

KRAS FLNA NRAS HRAS

4.59e-0487224HP:0034670
HumanPhenoHyperextensible skin

KRAS FLNA IFT140 HRAS TNXB

5.19e-04162225HP:0000974
HumanPhenoCraniofacial hyperostosis

KRAS FLNA LRP5

5.35e-0438223HP:0004493
HumanPhenoAbnormal renal morphology

KRAS FLNA IFT140 DLG5 NRAS HRAS PDX1 LRP5 DAAM2 PLEC TNXB NDUFS3 GFRA1

5.71e-0412522213HP:0012210
HumanPhenoEnlarged thorax

KRAS NRAS HRAS LRP5

6.17e-0494224HP:0100625
HumanPhenoHyperextensibility of the knee

KRAS NRAS HRAS

6.23e-0440223HP:0010500
HumanPhenoCerebellar malformation

KRAS FLNA IFT140 NRAS NFKB2 HRAS KIF5A TAF1

6.28e-04487228HP:0002438
HumanPhenoAlopecia

KRAS FLNA NRAS NFKB2 HRAS PLEC

6.36e-04261226HP:0001596
HumanPhenoAplasia cutis congenita

KRAS TAF1 PLEC

6.70e-0441223HP:0001057
HumanPhenoNail dysplasia

KRAS FLNA NFKB2 HRAS TAF1 PLEC

6.76e-04264226HP:0002164
HumanPhenoAbnormal epiphysis morphology of the phalanges of the hand

GDF5 FLNA IFT140

7.20e-0442223HP:0005920
HumanPhenoAbnormal 2nd finger morphology

GDF5 FLNA IFT140

7.72e-0443223HP:0004100
HumanPhenoBruising susceptibility

KRAS FLNA NRAS PLEC TNXB

7.99e-04178225HP:0000978
HumanPhenoAbnormally lax or hyperextensible skin

KRAS FLNA IFT140 HRAS TNXB

8.20e-04179225HP:0008067
HumanPhenoMegalencephaly

KRAS NRAS HRAS

8.26e-0444223HP:0001355
HumanPhenoPolycystic liver disease

IFT140 LRP5

9.57e-0411222HP:0006557
HumanPhenoFibular aplasia

GDF5 FLNA

9.57e-0411222HP:0002990
HumanPhenoNumerous nevi

NRAS HRAS

9.57e-0411222HP:0001054
HumanPhenoAbnormal cheek morphology

KRAS FLNA IFT140 NRAS HRAS LRP5

9.58e-04282226HP:0004426
HumanPhenoThickened helices

KRAS NRAS TAF1

1.00e-0347223HP:0000391
HumanPhenoAbnormal urine anion concentration

KRAS NRAS HRAS

1.00e-0347223HP:0011866
HumanPhenoRickets

KRAS NRAS HRAS

1.00e-0347223HP:0002748
HumanPhenoAbnormality of the pylorus

FLNA NFKB2 HRAS PLEC

1.01e-03107224HP:0004400
HumanPhenoChiari malformation

KRAS FLNA NFKB2 HRAS

1.01e-03107224HP:0002308
HumanPhenoSparse or absent hair

KRAS FLNA IFT140 NRAS NFKB2 HRAS TAF1 PLEC

1.04e-03525228HP:0002115
HumanPhenoChiari type I malformation

KRAS NFKB2 HRAS

1.07e-0348223HP:0007099
HumanPhenoAutoimmune thrombocytopenia

KRAS NRAS NFKB2

1.13e-0349223HP:0001973
HumanPhenoAbnormality of the premaxilla

NRAS HRAS

1.14e-0312222HP:0010758
HumanPhenoAbnormal bleeding

KRAS FLNA NRAS NFKB2 CD109 LRP5 PLEC TNXB

1.21e-03537228HP:0001892
HumanPhenoAbnormal joint physiology

KRAS GDF5 FLNA DLG5 NRAS HRAS PDX1 LRP5 KIF5A TAF1 PLEC TNXB NDUFS3

1.32e-0313582213HP:0034430
HumanPhenoAbnormality of joint mobility

KRAS GDF5 FLNA DLG5 NRAS HRAS PDX1 LRP5 KIF5A TAF1 PLEC TNXB NDUFS3

1.32e-0313582213HP:0011729
HumanPhenoHypophosphatemia

KRAS NRAS HRAS

1.42e-0353223HP:0002148
HumanPhenoCranial hyperostosis

KRAS FLNA LRP5

1.42e-0353223HP:0004437
HumanPhenoBroad forehead

KRAS FLNA NRAS HRAS LRP5

1.51e-03205225HP:0000337
HumanPhenoJoint hypermobility

KRAS GDF5 FLNA NRAS HRAS LRP5 TAF1 TNXB

1.54e-03557228HP:0001382
HumanPhenoAplasia/Hypoplasia of the middle phalanx of the 2nd finger

GDF5 IFT140

1.57e-0314222HP:0009568
HumanPhenoAbnormality of the middle phalanx of the 2nd finger

GDF5 IFT140

1.57e-0314222HP:0009543
HumanPhenoTricuspid valve prolapse

KRAS FLNA

1.57e-0314222HP:0001704
HumanPhenoSarcoma

KRAS GDF5 FLNA NRAS HRAS

1.68e-03210225HP:0100242
HumanPhenoFibroma

KRAS FLNA NRAS HRAS

1.74e-03124224HP:0010614
HumanPhenoMonocytosis

KRAS NRAS

1.81e-0315222HP:0012311
HumanPhenoMultiple lentigines

KRAS NRAS

1.81e-0315222HP:0001003
HumanPhenoFollicular hyperplasia

KRAS NRAS

1.81e-0315222HP:0002729
HumanPhenoFibrous tissue neoplasm

KRAS FLNA NRAS HRAS

1.85e-03126224HP:0012316
HumanPhenoIncreased skull ossification

KRAS FLNA LRP5

1.85e-0358223HP:0004330
HumanPhenoCoarse hair

KRAS FLNA NRAS

1.85e-0358223HP:0002208
HumanPhenoBasal cell carcinoma

KRAS NRAS HRAS

1.85e-0358223HP:0002671
MousePhenoabnormal abdominal wall morphology

KRAS PCSK5 FLNA IFT140 ATXN1L

4.46e-0582675MP:0003257
MousePhenothick retina inner plexiform layer

DSCAM DSCAML1

6.77e-053672MP:0014265
MousePhenospleen vascular congestion

KRAS PECAM1

6.77e-053672MP:0010020
MousePhenoabnormal body wall morphology

KRAS PCSK5 FLNA IFT140 FURIN ATXN1L

8.34e-05151676MP:0003385
MousePhenoomphalocele

PCSK5 FLNA IFT140 ATXN1L

1.18e-0453674MP:0003052
MousePhenohypertension

KRAS HRAS MAP3K15 WNK4

1.47e-0456674MP:0000231
DomainIg_E-set

PLXNA3 FLNA ARR3 NFKB2 CD109 PLXNA4

3.51e-06104746IPR014756
DomainIPT

PLXNA3 NFKB2 PLXNA4

1.63e-0427743SM00429
Domain-

EPPK1 PLEC

2.30e-0467423.90.1290.10
DomainPeptidase_S8_Asp-AS

PCSK5 FURIN

2.30e-046742IPR023827
DomainIPT

PLXNA3 NFKB2 PLXNA4

2.73e-0432743IPR002909
DomainPlectin_repeat

EPPK1 PLEC

3.21e-047742IPR001101
DomainPrprotnconvertsP

PCSK5 FURIN

3.21e-047742IPR002884
DomainPlectin

EPPK1 PLEC

3.21e-047742PF00681
DomainP_proprotein

PCSK5 FURIN

3.21e-047742PF01483
DomainS8_pro-domain

PCSK5 FURIN

3.21e-047742IPR032815
Domain-

PCSK5 FURIN

3.21e-0477423.30.70.850
DomainS8_pro-domain

PCSK5 FURIN

3.21e-047742PF16470
DomainPLEC

EPPK1 PLEC

3.21e-047742SM00250
DomainRAS

KRAS NRAS HRAS

3.57e-0435743PS51421
DomainSmall_GTPase_Ras

KRAS NRAS HRAS

4.21e-0437743IPR020849
DomainPeptidase_S8_His-AS

PCSK5 FURIN

5.48e-049742IPR022398
DomainPlexin_cytopl

PLXNA3 PLXNA4

5.48e-049742PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXNA4

5.48e-049742IPR013548
DomainPlexin

PLXNA3 PLXNA4

5.48e-049742IPR031148
DomainPeptidase_S8_Ser-AS

PCSK5 FURIN

5.48e-049742IPR023828
DomainPeptidase_S8_subtilisin-rel

PCSK5 FURIN

6.83e-0410742IPR015500
DomainSUBTILASE_ASP

PCSK5 FURIN

6.83e-0410742PS00136
DomainSUBTILASE_HIS

PCSK5 FURIN

6.83e-0410742PS00137
DomainSUBTILASE_SER

PCSK5 FURIN

6.83e-0410742PS00138
Domain-

PCSK5 FURIN

8.32e-04117423.40.50.200
DomainPeptidase_S8/S53_dom

PCSK5 FURIN

8.32e-0411742IPR000209
DomainGAIN_dom_N

CELSR3 CELSR2

8.32e-0411742IPR032471
DomainPeptidase_S8

PCSK5 FURIN

8.32e-0411742PF00082
DomainGAIN

CELSR3 CELSR2

8.32e-0411742PF16489
DomainCadherin_CS

CELSR3 CELSR2 CDH4 CDH18

9.23e-04109744IPR020894
DomainCADHERIN_1

CELSR3 CELSR2 CDH4 CDH18

1.06e-03113744PS00232
DomainCadherin

CELSR3 CELSR2 CDH4 CDH18

1.06e-03113744PF00028
DomainCADHERIN_2

CELSR3 CELSR2 CDH4 CDH18

1.09e-03114744PS50268
Domain-

CELSR3 CELSR2 CDH4 CDH18

1.09e-031147442.60.40.60
DomainCA

CELSR3 CELSR2 CDH4 CDH18

1.13e-03115744SM00112
DomainCadherin-like

CELSR3 CELSR2 CDH4 CDH18

1.16e-03116744IPR015919
Domain-

PLXNA3 FLNA DSCAM PTPRM NFKB2 PECAM1 PLXNA4 TNXB DSCAML1

1.20e-036637492.60.40.10
DomainCadherin

CELSR3 CELSR2 CDH4 CDH18

1.24e-03118744IPR002126
DomainEGF

CELSR3 CELSR2 LRP5 TNXB

1.58e-03126744PF00008
DomainIg-like_fold

PLXNA3 FLNA DSCAM PTPRM NFKB2 PECAM1 PLXNA4 TNXB DSCAML1

1.84e-03706749IPR013783
DomainPropept_inh

PCSK5 FURIN

2.03e-0317742IPR009020
DomainCH

FLNA MICAL3 PLEC

2.19e-0365743SM00033
DomainFurin_repeat

PCSK5 FURIN

2.27e-0318742IPR006212
DomainFU

PCSK5 FURIN

2.27e-0318742SM00261
DomainEGF

PCSK5 CELSR3 CELSR2 LRP5 TNXB

2.41e-03235745SM00181
DomainCH

FLNA MICAL3 PLEC

2.70e-0370743PF00307
Domain-

FLNA MICAL3 PLEC

2.81e-03717431.10.418.10
DomainCH

FLNA MICAL3 PLEC

3.04e-0373743PS50021
DomainEGF-like_dom

PCSK5 CELSR3 CELSR2 LRP5 TNXB

3.09e-03249745IPR000742
DomainCH-domain

FLNA MICAL3 PLEC

3.29e-0375743IPR001715
DomainGrowth_fac_rcpt_

PCSK5 CELSR2 FURIN TNXB

3.42e-03156744IPR009030
DomainActinin_actin-bd_CS

FLNA PLEC

3.71e-0323742IPR001589
DomainACTININ_2

FLNA PLEC

3.71e-0323742PS00020
DomainACTININ_1

FLNA PLEC

3.71e-0323742PS00019
Domainfn3

DSCAM PTPRM TNXB DSCAML1

3.92e-03162744PF00041
PathwayREACTOME_ACTIVATION_OF_RAS_IN_B_CELLS

KRAS NRAS HRAS

7.29e-075603M26921
PathwayREACTOME_ESTROGEN_STIMULATED_SIGNALING_THROUGH_PRKCZ

KRAS NRAS HRAS

1.45e-066603M27951
PathwayKEGG_MEDICUS_VARIANT_LOSS_OF_RASSF1_TO_RAS_RASSF1_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.45e-066603M47433
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RAS_UBIQUITINATION_BY_CUL3_COMPLEX

KRAS NRAS HRAS

1.45e-066603M47931
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_SPRED_AND_NF1

KRAS NRAS HRAS

1.45e-066603M47932
PathwayREACTOME_RAS_SIGNALING_DOWNSTREAM_OF_NF1_LOSS_OF_FUNCTION_VARIANTS

KRAS NRAS HRAS

2.53e-067603M29717
PathwayREACTOME_SOS_MEDIATED_SIGNALLING

KRAS NRAS HRAS

2.53e-067603M19489
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RASGAP

KRAS NRAS HRAS

4.04e-068603M47935
PathwayREACTOME_ACTIVATED_NTRK3_SIGNALS_THROUGH_RAS

KRAS NRAS HRAS

4.04e-068603M27919
PathwayREACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN

KRAS NRAS HRAS

6.05e-069603M27156
PathwayREACTOME_SHC_RELATED_EVENTS_TRIGGERED_BY_IGF1R

KRAS NRAS HRAS

6.05e-069603M27173
PathwayREACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_RAS

KRAS NRAS HRAS

6.05e-069603M27904
PathwayREACTOME_MET_ACTIVATES_RAS_SIGNALING

KRAS NRAS HRAS

1.18e-0511603M27740
PathwayREACTOME_SIGNALING_BY_FGFR4_IN_DISEASE

KRAS NRAS HRAS

1.18e-0511603M27535
PathwayKEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.18e-0511603M47370
PathwayKEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.18e-0511603M47371
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2

KRAS NRAS HRAS

1.18e-0511603M29814
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RALGDS_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.18e-0511603M47436
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RASSF1_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.18e-0511603M47432
PathwayREACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FRS2_AND_FRS3

KRAS NRAS HRAS

1.18e-0511603M27911
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.57e-0512603M47369
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.57e-0512603M47815
PathwayREACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS

KRAS NRAS HRAS

1.57e-0512603M29851
PathwayWP_RALA_DOWNSTREAM_REGULATED_GENES

KRAS NRAS HRAS

1.57e-0512603M39408
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.03e-0513603M47594
PathwayREACTOME_P38MAPK_EVENTS

KRAS NRAS HRAS

2.03e-0513603M1441
PathwayREACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES

KRAS NRAS HRAS

2.58e-0514603M27734
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.58e-0514603M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.58e-0514603M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.58e-0514603M47366
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.58e-0514603M47390
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.58e-0514603M47378
PathwayREACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING

KRAS NRAS HRAS

2.58e-0514603M569
PathwayPID_TCR_RAS_PATHWAY

KRAS NRAS HRAS

2.58e-0514603M134
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.58e-0514603M47488
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_RAS

KRAS NRAS HRAS

2.58e-0514603M27908
PathwayREACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING

KRAS NRAS HRAS

2.58e-0514603M719
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_EGFRVIII

KRAS NRAS HRAS

3.22e-0515603M29701
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47367
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47389
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47375
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47474
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47475
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.22e-0515603M47531
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.95e-0516603M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.95e-0516603M47373
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.95e-0516603M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.95e-0516603M47804
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.95e-0516603M47801
PathwayREACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

KRAS NRAS HRAS

3.95e-0516603M562
PathwayREACTOME_SIGNALING_BY_ERBB2_ECD_MUTANTS

KRAS NRAS HRAS

3.95e-0516603M29847
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.95e-0516603M47483
PathwayREACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS

KRAS NRAS HRAS

3.95e-0516603M41733
PathwayKEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.95e-0516603M47682
PathwayWP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY

KRAS NRAS HRAS PLEC

4.23e-0546604M39828
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

4.78e-0517603M47376
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY

KRAS NRAS HRAS

4.78e-0517603M47684
PathwayREACTOME_SIGNALING_BY_NTRK3_TRKC

KRAS NRAS HRAS

4.78e-0517603M27918
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR3

KRAS NRAS HRAS

5.72e-0518603M27518
PathwayWP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS

KRAS NRAS HRAS

5.72e-0518603M39737
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

KRAS NRAS HRAS

5.72e-0518603M657
PathwayREACTOME_TIE2_SIGNALING

KRAS NRAS HRAS

5.72e-0518603M11932
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

6.77e-0519603M47793
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_LIGAND_RESPONSIVE_EGFR_CANCER_VARIANTS

KRAS NRAS HRAS

6.77e-0519603M559
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

KRAS NRAS HRAS

6.77e-0519603M27423
PathwayREACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS

KRAS NRAS HRAS

6.77e-0519603M41732
PathwayREACTOME_SIGNALING_BY_EGFR

KRAS NRAS HRAS FAM83B

7.43e-0553604M27039
PathwayREACTOME_SIGNALLING_TO_RAS

KRAS NRAS HRAS

7.94e-0520603M12256
PathwayREACTOME_FRS_MEDIATED_FGFR3_SIGNALING

KRAS NRAS HRAS

7.94e-0520603M27519
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR4

KRAS NRAS HRAS

7.94e-0520603M27524
PathwayWP_SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4_SIGNALING

KRAS NRAS HRAS

7.94e-0520603M39485
PathwayREACTOME_SIGNALING_BY_PDGFR_IN_DISEASE

KRAS NRAS HRAS

7.94e-0520603M29849
PathwayREACTOME_RAS_ACTIVATION_UPON_CA2_INFLUX_THROUGH_NMDA_RECEPTOR

KRAS NRAS HRAS

7.94e-0520603M17670
PathwayREACTOME_SIGNALING_BY_KIT_IN_DISEASE

KRAS NRAS HRAS

7.94e-0520603M39002
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR1

KRAS NRAS HRAS

9.23e-0521603M27511
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.23e-0521603M47792
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

KRAS NRAS HRAS

9.23e-0521603M27485
PathwayREACTOME_SIGNALING_BY_PDGF

KRAS NRAS FURIN HRAS

1.06e-0458604M2049
PathwayREACTOME_FRS_MEDIATED_FGFR4_SIGNALING

KRAS NRAS HRAS

1.07e-0422603M27522
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

KRAS NRAS HRAS

1.07e-0422603M26929
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

KRAS PLXNA3 DSCAM HRAS PLXNA4 DSCAML1 GFRA1

1.15e-04261607MM15676
PathwayREACTOME_FRS_MEDIATED_FGFR1_SIGNALING

KRAS NRAS HRAS

1.22e-0423603M27513
PathwayKEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.22e-0423603M47799
PathwayREACTOME_RAS_PROCESSING

KRAS NRAS HRAS

1.39e-0424603M38995
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

KRAS NRAS HRAS GFRA1

1.46e-0463604M11187
PathwayPID_TCR_PATHWAY

KRAS FLNA NRAS HRAS

1.56e-0464604M34
PathwayREACTOME_FRS_MEDIATED_FGFR2_SIGNALING

KRAS NRAS HRAS

1.58e-0425603M27517
PathwayWP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR

KRAS NRAS HRAS

1.58e-0425603M39794
Pubmed

H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice.

KRAS NRAS PECAM1 HRAS

7.33e-10776420179099
Pubmed

Diagnostic Value of RAS Mutations in Indeterminate Thyroid Nodules.

KRAS NRAS HRAS

1.00e-08376328116986
Pubmed

RAS gene mutations and histomorphometric measurements in oral squamous cell carcinoma.

KRAS NRAS HRAS

1.00e-08376337013448
Pubmed

Mutations of RAS gene family in specimens of bladder cancer.

KRAS NRAS HRAS

1.00e-08376319101897
Pubmed

Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.

KRAS NRAS HRAS

1.00e-08376325977330
Pubmed

Promoter hypomethylation as potential confounder of Ras gene overexpression and their clinical significance in subsets of urothelial carcinoma of bladder.

KRAS NRAS HRAS

1.00e-08376333620658
Pubmed

A comprehensive survey of Ras mutations in cancer.

KRAS NRAS HRAS

1.00e-08376322589270
Pubmed

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.

KRAS NRAS HRAS

1.00e-08376323496764
Pubmed

Distribution of p21ras during primary palate formation of non-cleft and cleft strains of mice.

KRAS NRAS HRAS

1.00e-0837637776260
Pubmed

The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.

KRAS NRAS HRAS

1.00e-08376328630043
Pubmed

Overexpression of wild-type p21Ras plays a prominent role in colorectal cancer.

KRAS NRAS HRAS

1.00e-08376328259994
Pubmed

The variable phenotype and low-risk nature of RAS-positive thyroid nodules.

KRAS NRAS HRAS

1.00e-08376326253102
Pubmed

Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.

KRAS NRAS HRAS

1.00e-08376316573741
Pubmed

Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.

KRAS NRAS HRAS

1.00e-08376325788415
Pubmed

Analysis of k-ras nuclear expression in fibroblasts and mesangial cells.

KRAS NRAS HRAS

1.00e-08376320090846
Pubmed

Comparison of liver oncogenic potential among human RAS isoforms.

KRAS NRAS HRAS

1.00e-08376326799184
Pubmed

A pericyte origin of spinal cord scar tissue.

KRAS NRAS HRAS

1.00e-08376321737741
Pubmed

Ras isoforms: signaling specificities in CD40 pathway.

KRAS NRAS HRAS

1.00e-08376331906952
Pubmed

Partial functional overlap of the three ras genes in mouse embryonic development.

KRAS NRAS HRAS

1.00e-08376318059342
Pubmed

Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.

KRAS NRAS HRAS

1.00e-08376323240926
Pubmed

Prevalence of RAS point mutations in papillary thyroid carcinoma; a novel mutation at codon 31 of K-RAS.

KRAS NRAS HRAS

1.00e-08376317943694
Pubmed

Absolute Quantification of Endogenous Ras Isoform Abundance.

KRAS NRAS HRAS

1.00e-08376326560143
Pubmed

Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.

KRAS NRAS HRAS

1.00e-08376317712732
Pubmed

Comprehensive survey of HRAS, KRAS, and NRAS mutations in proliferative thyroid lesions from an ethnically diverse population.

KRAS NRAS HRAS

1.00e-08376324222113
Pubmed

Deciphering the RAS/ERK pathway in vivo.

KRAS NRAS HRAS

1.00e-08376328202657
Pubmed

Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.

KRAS NRAS HRAS

1.00e-08376316761621
Pubmed

Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis.

KRAS NRAS HRAS

1.00e-08376322945650
Pubmed

Activation of RAS family genes in urothelial carcinoma.

KRAS NRAS HRAS

1.00e-08376319303097
Pubmed

The spatiotemporal regulation of RAS signalling.

KRAS NRAS HRAS

1.00e-08376327911734
Pubmed

Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients.

KRAS NRAS HRAS

1.00e-08376320150643
Pubmed

Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.

KRAS NRAS HRAS

1.00e-08376320971740
Pubmed

Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.

KRAS NRAS HRAS

1.00e-08376327119512
Pubmed

K-ras is an essential gene in the mouse with partial functional overlap with N-ras.

KRAS NRAS HRAS

1.00e-0837639334313
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCSK5 PLXNA3 FLNA KIAA0930 EPPK1 ABR CELSR3 CELSR2 FURIN NFKB2 LRP5 TLN2 MICAL3 FAM110A PLEC

1.43e-081105761535748872
Pubmed

CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces.

PCSK5 GDF5 FURIN

4.00e-08476316829522
Pubmed

The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.

KRAS NRAS HRAS

4.00e-08476327936046
Pubmed

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.

KRAS NRAS HRAS

4.00e-08476329502968
Pubmed

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

KRAS NRAS HRAS

4.00e-0847637972015
Pubmed

Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.

KRAS NRAS HRAS

4.00e-08476310490827
Pubmed

Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.

KRAS NRAS HRAS

4.00e-08476325999467
Pubmed

Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.

KRAS NRAS HRAS

4.00e-08476310085069
Pubmed

Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice.

KRAS NRAS HRAS

4.00e-08476338849523
Pubmed

Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members.

KRAS NRAS HRAS

4.00e-08476334948093
Pubmed

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.

KRAS NRAS HRAS

4.00e-0847639674433
Pubmed

Ras membrane orientation and nanodomain localization generate isoform diversity.

KRAS NRAS HRAS

4.00e-08476320080631
Pubmed

Quantification of spatiotemporal patterns of Ras isoform expression during development.

KRAS NRAS HRAS

4.00e-08476328117393
Pubmed

Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.

KRAS NRAS HRAS

1.00e-07576322982107
Pubmed

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

KRAS NRAS HRAS

1.00e-07576334535655
Pubmed

The complexity of Raf-1 regulation.

KRAS NRAS HRAS

1.00e-0757639069260
Pubmed

Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.

KRAS NRAS HRAS

1.00e-07576324746824
Pubmed

Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.

KRAS NRAS HRAS

1.00e-07576315558479
Pubmed

Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf.

KRAS NRAS HRAS

2.00e-0767639753431
Pubmed

FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.

KRAS NRAS HRAS

2.00e-07676321072204
Pubmed

Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1.

KRAS NRAS HRAS

2.00e-07676310882715
Pubmed

Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.

KRAS NRAS HRAS

2.00e-07676329615452
Pubmed

LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases.

KRAS NRAS HRAS

2.00e-07676331337872
Pubmed

Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.

KRAS NRAS HRAS

3.49e-07776319487299
Pubmed

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

KRAS NRAS HRAS

3.49e-07776320526288
Pubmed

Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas.

KRAS NRAS HRAS

3.49e-07776320012784
Pubmed

The structural basis of the activation of Ras by Sos.

KRAS NRAS HRAS

3.49e-0777639690470
Pubmed

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.

KRAS NRAS HRAS

3.49e-07776335904492
Pubmed

SmgGDS displays differential binding and exchange activity towards different Ras isoforms.

KRAS NRAS HRAS

3.49e-07776311948427
Pubmed

Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension.

KRAS NRAS HRAS

3.49e-07776320860430
Pubmed

Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.

KRAS NRAS HRAS

3.49e-07776322199277
Pubmed

Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.

KRAS NRAS HRAS

5.57e-07876315064703
Pubmed

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

KRAS NRAS HRAS

5.57e-07876320150892
Pubmed

Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis.

KRAS NRAS HRAS

8.34e-0797639344703
Pubmed

The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.

KRAS NRAS HRAS

8.34e-07976310783161
Pubmed

Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.

KRAS NRAS HRAS

1.19e-061076334215617
Pubmed

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.

KRAS NRAS HRAS

1.19e-061076329959233
Pubmed

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.

KRAS NRAS HRAS

1.63e-061176328263956
Pubmed

CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.

KRAS NRAS HRAS

2.17e-06127639269777
Pubmed

Ras effectors and their role in mitogenesis and oncogenesis.

KRAS NRAS HRAS

2.17e-06127639297626
Pubmed

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.

PLXNA3 PECAM1 PLXNA4

2.82e-061376322723296
Pubmed

K-RasV14I recapitulates Noonan syndrome in mice.

KRAS NRAS HRAS

3.59e-061476325359213
Pubmed

Ras signaling is essential for skin development.

KRAS NRAS HRAS

4.48e-061576323831572
Pubmed

The Ras branch of small GTPases: Ras family members don't fall far from the tree.

KRAS NRAS HRAS

4.48e-061576310712923
Pubmed

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.

KRAS NRAS

4.71e-06276219789336
Pubmed

Involvement of H- and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis.

NRAS HRAS

4.71e-06276216624289
Pubmed

Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.

KRAS NRAS

4.71e-06276227698462
Pubmed

Frequent KRAS and HRAS mutations in squamous cell papillomas of the head and neck.

KRAS HRAS

4.71e-06276231960612
Pubmed

Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay.

NRAS HRAS

4.71e-0627621970154
Pubmed

Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.

KRAS HRAS

4.71e-06276220188103
Pubmed

Complete Screening of Exons 2, 3, and 4 of KRAS and NRAS Genes Reveals a Higher Number of Clinically Relevant Mutations than Food and Drug Administration Quantitative Polymerase Chain Reaction-Based Commercial Kits.

KRAS NRAS

4.71e-06276233053566
Pubmed

Promotion of cancer cell stemness by Ras.

KRAS HRAS

4.71e-06276233544116
Pubmed

Ras gene mutations in patients with acute myeloid leukaemia and exposure to chemical agents.

KRAS NRAS

4.71e-06276214688017
Pubmed

RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant.

KRAS NRAS

4.71e-06276220371679
Pubmed

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations.

KRAS NRAS

4.71e-06276239455841
Pubmed

Prevalence of RAS mutations and individual variation patterns among patients with metastatic colorectal cancer: A pooled analysis of randomised controlled trials.

KRAS NRAS

4.71e-06276226049686
Pubmed

Common KRAS and NRAS gene mutations in sporadic colorectal cancer in Northeastern Iranian patients.

KRAS NRAS

4.71e-06276229921458
Pubmed

Plasma membrane phosphatidylinositol 4-phosphate and 4,5-bisphosphate determine the distribution and function of K-Ras4B but not H-Ras proteins.

KRAS HRAS

4.71e-06276228939768
Pubmed

Plakins in development and disease.

EPPK1 PLEC

4.71e-06276217499243
Pubmed

Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia.

KRAS NRAS

4.71e-06276224737308
Pubmed

Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways.

KRAS HRAS

4.71e-06276217210246
Pubmed

Loss of Heterozygosity and Mutations in the RAS-ERK Pathway Genes in Tumor Cells of Various Loci in Multiple Myeloma.

KRAS NRAS

4.71e-06276239273371
Pubmed

Clinicopathologic characteristics and gene expression analyses of non-KRAS 12/13, RAS-mutated metastatic colorectal cancer.

KRAS NRAS

4.71e-06276225009008
Pubmed

Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations.

KRAS NRAS

4.71e-06276228859058
Pubmed

RAS mutations predict radiologic and pathologic response in patients treated with chemotherapy before resection of colorectal liver metastases.

KRAS NRAS

4.71e-06276225227306
Pubmed

Cervical mesonephric hyperplasia lacks KRAS/NRAS mutations.

KRAS NRAS

4.71e-06276228703285
Pubmed

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

KRAS NRAS

4.71e-06276217332249
InteractionITGB6 interactions

KRAS FLNA NRAS HRAS

1.82e-0714764int:ITGB6
InteractionDKKL1 interactions

CELSR3 CELSR2 LTN1 CD109 LRP5 DHX32 MMP15

2.03e-07111767int:DKKL1
InteractionHEPH interactions

KRAS NRAS HRAS

1.02e-066763int:HEPH
InteractionPLCD1 interactions

KRAS GDF5 NRAS HRAS PLEC

2.19e-0656765int:PLCD1
InteractionTRPV2 interactions

KRAS NRAS HRAS

6.07e-0610763int:TRPV2
InteractionANK3 interactions

KRAS FLNA DLG5 ABR PPP1R12B MICAL3 PLEC

1.08e-05201767int:ANK3
InteractionGTSF1 interactions

KRAS NRAS HRAS

1.11e-0512763int:GTSF1
InteractionEPS8 interactions

KRAS NFKB2 SHB HRAS BYSL XRCC6

1.25e-05136766int:EPS8
InteractionCDC42BPA interactions

KRAS EPPK1 NRAS PTPRM HRAS TAF1

1.88e-05146766int:CDC42BPA
InteractionSFT2D1 interactions

KRAS MYG1 NRAS HRAS

2.06e-0543764int:SFT2D1
InteractionSNRNP40 interactions

KRAS FLNA DDX17 PRPF40B CWC15 ZC3H13 ATAD2B ZNF318 SREK1 MGA ATXN1L

2.56e-056377611int:SNRNP40
InteractionAURKB interactions

KRAS FLNA DLG5 EPPK1 DDX17 NRAS ABR BYSL TAF1 PLEC NDUFS3 XRCC6

2.60e-057617612int:AURKB
InteractionTOP3B interactions

PCSK5 PLXNA3 FLNA KIAA0930 EPPK1 ABR CELSR3 CELSR2 FURIN NFKB2 BYSL LRP5 TLN2 MICAL3 FAM110A PLEC XRCC6

2.62e-0514707617int:TOP3B
InteractionELMOD3 interactions

KRAS NRAS HRAS

2.79e-0516763int:ELMOD3
InteractionSAMSN1 interactions

KRAS NRAS HRAS

2.79e-0516763int:SAMSN1
InteractionSPTA1 interactions

KRAS NRAS HRAS PLEC XRCC6

2.82e-0594765int:SPTA1
InteractionAFDN interactions

KRAS DLG5 NRAS DSCAM SHB HRAS FAM110A FAM83B

3.63e-05333768int:AFDN
InteractionNCAM1 interactions

KRAS NRAS DSCAM HRAS GFRA1

3.99e-05101765int:NCAM1
InteractionKRT8 interactions

DLG5 EPPK1 LTN1 BYSL PLEC CLUH GFRA1 XRCC6 FAM83B

4.13e-05441769int:KRT8
InteractionMETTL14 interactions

KRAS FLNA ERICH3 DDX17 CELSR3 ZC3H13 MAP3K15 KIF5A PLEC XRCC6

4.52e-055587610int:METTL14
InteractionNOTCH1 interactions

KRAS DDX17 NRAS PPP1R12B FURIN HRAS TAF1 XRCC6

4.66e-05345768int:NOTCH1
InteractionSHISA2 interactions

KRAS NRAS ATXN1L

4.78e-0519763int:SHISA2
InteractionGYPC interactions

KRAS NRAS HRAS

4.78e-0519763int:GYPC
InteractionSTMN3 interactions

KRAS ZNF76 MICAL3 KIF5A

5.50e-0555764int:STMN3
InteractionSLC6A9 interactions

KRAS NRAS HRAS

5.61e-0520763int:SLC6A9
InteractionSUSD5 interactions

KRAS NRAS HRAS

5.61e-0520763int:SUSD5
InteractionLHX3 interactions

BYSL KDM2B ZNF76 TAF1 MGA ATXN1L

7.08e-05185766int:LHX3
InteractionPIK3CG interactions

KRAS NRAS PECAM1 HRAS

7.26e-0559764int:PIK3CG
InteractionNECTIN1 interactions

KRAS NRAS HRAS

7.54e-0522763int:NECTIN1
InteractionALKBH3 interactions

KRAS FLNA ALKBH3 MGA

8.28e-0561764int:ALKBH3
InteractionGAL3ST4 interactions

NRAS XRCC6

8.38e-054762int:GAL3ST4
InteractionCHMP4B interactions

KRAS FLNA TAF8 EPPK1 DDX17 CD109 TLN2 TAF1 PLEC XRCC6 FAM83B

8.45e-057277611int:CHMP4B
InteractionSEMA6D interactions

KRAS PLXNA3 PLXNA4

8.65e-0523763int:SEMA6D
InteractionSLC23A2 interactions

KRAS NRAS HRAS

8.65e-0523763int:SLC23A2
InteractionDEPDC1B interactions

KRAS EPPK1 NRAS HRAS FAM110A PLEC

8.69e-05192766int:DEPDC1B
InteractionSEMA6A interactions

KRAS PLXNA3 NRAS PLXNA4

9.40e-0563764int:SEMA6A
InteractionWDR76 interactions

KRAS FLNA EPPK1 NRAS HRAS TAF1 PLEC XRCC6

9.67e-05383768int:WDR76
InteractionCLDN3 interactions

KRAS HRAS WNK4

9.85e-0524763int:CLDN3
InteractionTAOK3 interactions

KRAS NRAS HRAS ALKBH3

1.00e-0464764int:TAOK3
InteractionIL5RA interactions

PCSK5 PLXNA3 CELSR2 LRP5 MMP15

1.06e-04124765int:IL5RA
InteractionROR1 interactions

KRAS EPPK1 NRAS HRAS PLEC

1.14e-04126765int:ROR1
InteractionCLDN1 interactions

KRAS HRAS WNK4

1.26e-0426763int:CLDN1
InteractionSLITRK2 interactions

KRAS NRAS

1.39e-045762int:SLITRK2
InteractionPDLIM4 interactions

KRAS NRAS HRAS

1.41e-0427763int:PDLIM4
InteractionSAP18 interactions

KRAS CELSR2 ZC3H13 LTN1 ANO7 TAF1 SREK1

1.52e-04305767int:SAP18
InteractionRGL2 interactions

KRAS NRAS HRAS

1.58e-0428763int:RGL2
InteractionPTPRM interactions

KRAS PCSK5 PTPRM HRAS

1.58e-0472764int:PTPRM
InteractionSLC7A5 interactions

KRAS FLNA NRAS FURIN HRAS MAP3K15

1.61e-04215766int:SLC7A5
InteractionDCUN1D3 interactions

KRAS NRAS HRAS

1.75e-0429763int:DCUN1D3
InteractionSLC35A2 interactions

KRAS NRAS HRAS

1.75e-0429763int:SLC35A2
InteractionSPTBN1 interactions

KRAS FLNA NRAS DSCAM HRAS SCRN1 SREK1 XRCC6

1.85e-04421768int:SPTBN1
InteractionSLC1A4 interactions

KRAS NRAS HRAS

1.94e-0430763int:SLC1A4
InteractionCD276 interactions

KRAS NRAS HRAS

1.94e-0430763int:CD276
InteractionDCBLD1 interactions

KRAS NRAS HRAS

2.15e-0431763int:DCBLD1
InteractionJAM3 interactions

KRAS NRAS HRAS

2.15e-0431763int:JAM3
InteractionBTK interactions

KRAS FLNA NRAS HRAS TTC9C

2.21e-04145765int:BTK
InteractionMEAK7 interactions

KRAS NRAS HRAS

2.36e-0432763int:MEAK7
InteractionCHMP6 interactions

KRAS NRAS HRAS

2.59e-0433763int:CHMP6
InteractionST8SIA4 interactions

PLXNA3 CELSR2 CD109 LRP5

2.87e-0484764int:ST8SIA4
InteractionCIT interactions

FLNA EPPK1 DDX17 CELSR2 DSCAM CWC15 ZC3H13 CD109 BYSL SREK1 PLEC MMP15 CCDC180 NDUFS3 XRCC6

2.91e-0414507615int:CIT
InteractionSEMA5A interactions

PLXNA3 PLXNA4

2.91e-047762int:SEMA5A
InteractionLRRC57 interactions

KRAS NRAS HRAS

3.09e-0435763int:LRRC57
InteractionSLC2A3 interactions

KRAS NRAS HRAS

3.09e-0435763int:SLC2A3
InteractionSEMA4D interactions

KRAS NRAS DSCAM

3.09e-0435763int:SEMA4D
InteractionITGA6 interactions

KRAS PCSK5 NRAS HRAS PLEC

3.09e-04156765int:ITGA6
InteractionMBD5 interactions

DDX17 SCRN1 ZNF76 XRCC6

3.14e-0486764int:MBD5
InteractionSIRPD interactions

PLXNA3 CELSR2 LRP5 MMP15

3.14e-0486764int:SIRPD
InteractionZDHHC20 interactions

KRAS NRAS HRAS

3.36e-0436763int:ZDHHC20
InteractionFAM83F interactions

KRAS HRAS FAM83B

3.36e-0436763int:FAM83F
InteractionCEP104 interactions

KRAS DLG5 NRAS HRAS

3.58e-0489764int:CEP104
InteractionGAN interactions

DLG5 TAF8 CELSR3 ZC3H13 PLEC CLUH

3.87e-04253766int:GAN
InteractionC2orf72 interactions

KRAS NRAS

3.87e-048762int:C2orf72
InteractionSSX6P interactions

CELSR2 PLEC

3.87e-048762int:SSX6P
InteractionMAP4K4 interactions

KRAS NRAS DSCAM CWC15 HRAS KIF5A

3.95e-04254766int:MAP4K4
InteractionTTC4 interactions

KRAS DDX17 NRAS TLN2 GFRA1

4.00e-04165765int:TTC4
InteractionRASA1 interactions

KRAS FLNA NRAS HRAS XRCC6

4.23e-04167765int:RASA1
InteractionATP7A interactions

KRAS NRAS FURIN HRAS

4.23e-0493764int:ATP7A
InteractionADD2 interactions

KRAS NRAS PECAM1 HRAS

4.23e-0493764int:ADD2
InteractionPCDH9 interactions

KRAS NRAS HRAS

4.27e-0439763int:PCDH9
InteractionKIF23 interactions

KRAS FLNA DLG5 EPPK1 DDX17 ZC3H13 CD109 MICAL3 PLEC NDUFS3 XRCC6 FAM83B

4.52e-0410317612int:KIF23
InteractionNDRG3 interactions

KRAS NRAS HRAS

4.61e-0440763int:NDRG3
InteractionTRPM4 interactions

KRAS NRAS HRAS

4.61e-0440763int:TRPM4
InteractionECT2 interactions

FLNA EPPK1 DDX17 ABR CD109 BYSL MICAL3 SREK1 PLEC XRCC6 FAM83B

4.72e-048877611int:ECT2
InteractionROBO1 interactions

KRAS NRAS DSCAM HRAS

4.77e-0496764int:ROBO1
InteractionSIGLEC6 interactions

ZNF655 HRAS

4.97e-049762int:SIGLEC6
InteractionCAVIN4 interactions

BYSL XRCC6

4.97e-049762int:CAVIN4
InteractionMYH9 interactions

KRAS FLNA PPP1R12B LTN1 CD109 CASP4 MICAL3 PLEC CCDC180 XRCC6

5.19e-047547610int:MYH9
InteractionMTMR10 interactions

KRAS NRAS DSCAM

5.32e-0442763int:MTMR10
InteractionMITD1 interactions

DSCAM ZNF655 HRAS

5.32e-0442763int:MITD1
InteractionNUP210P1 interactions

IFT140 CELSR3 CELSR2

5.32e-0442763int:NUP210P1
InteractionDEFB135 interactions

PLXNA3 CD109 LRP5

5.32e-0442763int:DEFB135
InteractionCELSR2 interactions

KRAS NRAS CELSR2 HRAS

5.57e-04100764int:CELSR2
InteractionSIRPA interactions

KRAS FLNA NRAS HRAS

5.57e-04100764int:SIRPA
InteractionNUP43 interactions

FLNA DDX17 DSCAM ZC3H13 ATAD2B BYSL ZNF318 SREK1 MGA

5.60e-04625769int:NUP43
InteractionNAV2 interactions

KRAS NRAS HRAS

5.71e-0443763int:NAV2
InteractionPPFIBP2 interactions

KRAS NRAS HRAS

5.71e-0443763int:PPFIBP2
InteractionTRIM37 interactions

DLG5 EPPK1 DSCAM ZNF655 BYSL ZNF318 PLEC MGA XRCC6

5.93e-04630769int:TRIM37
InteractionDSCAML1 interactions

DSCAM DSCAML1

6.19e-0410762int:DSCAML1
InteractionZBTB12 interactions

KRAS HRAS

6.19e-0410762int:ZBTB12
InteractionARPC3 interactions

KRAS FLNA FURIN ANO7 CLUH

6.41e-04183765int:ARPC3
CytobandEnsembl 112 genes in cytogenetic band chr6p21

TAF8 BYSL DAAM2 ZNF76 ZNF318 TNXB

1.92e-04503766chr6p21
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR3 CELSR2

2.82e-053562913
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR3 CELSR2

2.82e-0535621189
GeneFamilyRAS type GTPase family

KRAS NRAS HRAS

1.19e-0431563389
GeneFamilyEF-hand domain containing|Plakins

EPPK1 PLEC

2.61e-048562939
GeneFamilyProprotein convertase subtilisin/kexin family

PCSK5 FURIN

3.35e-049562973
GeneFamilyPlexins

PLXNA3 PLXNA4

3.35e-049562683
GeneFamilyFibronectin type III domain containing

DSCAM PTPRM TNXB DSCAML1

1.52e-03160564555
GeneFamilyImmunoglobulin like domain containing

DSCAM PTPRM PECAM1 DSCAML1

3.00e-03193564594
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 DSCAM PTPRM SHB MICAL3 GFRA1

5.73e-071767667292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 DSCAM PTPRM SHB MICAL3 GFRA1

5.73e-0717676688ca2f83d8301633232735f39b0683efe49d0b86
ToppCelldroplet-Bladder-Unstain-18m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA KIAA0930 EPPK1 FURIN PLEC MMP15

1.07e-061967660d040ae2ce8a0e1a59145a9b9eaa979239c477ff
ToppCelldroplet-Bladder-Unstain|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA KIAA0930 EPPK1 FURIN PLEC MMP15

1.07e-06196766f240056e63aca02f25ea29bc9d34eedcf0f1c811
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PTPRM PECAM1 CD109 PLEC TNXB

1.17e-06199766a3ec743b978ba8fdf1677b4971b5731f50ddd30f
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PCSK5 FLNA PPP1R12B PLXNA4 DAAM2 TNXB

1.17e-0619976638cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PCSK5 FLNA PPP1R12B PLXNA4 DAAM2 TNXB

1.21e-0620076687827041663013f5e7273168dc8709d69840e7ce
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PCSK5 FLNA PPP1R12B PLXNA4 DAAM2 TNXB

1.21e-0620076609537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CELSR2 MMP15 CDH4 GFRA1 POLR3G

1.31e-051777650417460bdb012bc43d7254377fa53d79cdab3f34
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PLXNA4 DAAM2 TNXB GFRA1

1.54e-051837657eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PLXNA4 DAAM2 TNXB GFRA1

1.54e-0518376512daaea821e49bc94a01e2496331e92a80d27339
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PLXNA4 DAAM2 TNXB GFRA1

1.89e-0519176514057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERICH3 EPPK1 CCDC180 GFRA1 DNAH11

1.89e-051917656a8fc9dc1a4c7115862e8f20204fa2f95e50e22f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

1.94e-0519276528eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRM PECAM1 CD109 LRP5 TNXB

1.99e-05193765daefbfd3a3dd1351fbe94b9abfd807db44d56c24
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 PLXNA4

1.99e-051937650b328f725f6feba263783eaca60c142e80df90f3
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PCSK5 FLNA PPP1R12B PLXNA4 GFRA1

2.09e-051957654dba732c8d8ecf0ed9ece1814dc4060402199ed9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.14e-051967658ad8efb631164b46f0c082572270188e5ead20bf
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.14e-05196765b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.14e-051967659606ea7e42f707e69ea891b3521037613b9675f5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.14e-05196765145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.14e-05196765d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.20e-05197765cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.20e-05197765412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell(2)_Fibroblasts-(24)_Fibro-5|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

KRAS CD109 DAAM2 PLEC TNXB

2.20e-0519776583a4b79fbfa1cf63441dee4424c3b87c988287bf
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.25e-05198765b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITPKC EPPK1 SHB HRAS FAM83B

2.25e-0519876577517df37dc894c78ef1e2b24dd7ba31f928bdb7
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.25e-05198765953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109 TNXB

2.25e-051987658e45551224fbb30c0658ad47dd98335ecf165437
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PCSK5 FLNA PPP1R12B PLXNA4 TNXB

2.30e-05199765e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PTPRM PECAM1 CD109 PLEC

2.30e-051997659b02acae6325b0ac9642438a4431285ff396e5fe
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLXNA3 FLNA ARR3 SHB PLEC

2.30e-0519976585bb28369e0568b7b3bda095722102fc793f60ef
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PCSK5 PPP1R12B PLXNA4 DAAM2 TNXB

2.30e-051997656b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Cortical_neuron|GW23 / Sample Type, Dataset, Time_group, and Cell type.

PLXNA3 ABR PLXNA4 KIF5A CDH4

2.36e-052007657bba2ff09349c8db3d1ccf53520b12cbf7b0abac
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 FLNA PPP1R12B PLXNA4 TNXB

2.36e-052007659d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 PPP1R12B PLXNA4 DAAM2 TNXB

2.36e-05200765a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PECAM1 CD109 PLEC TNXB

2.36e-0520076593e13937ec74418a697c37d56f57509fb2154780
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

DLG5 KIAA0930 CELSR2 PLXNA4 SCRN1

2.36e-05200765c92e4fc0442404481fcac623d691dae6215b852d
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PCSK5 FLNA PPP1R12B PLXNA4 CDH4

2.36e-052007658988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PCSK5 FLNA PPP1R12B PLXNA4 TNXB

2.36e-0520076508bf8c00eee6468215edb3611296bfc8784c4d56
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

PCSK5 PPP1R12B PLXNA4 DAAM2 TNXB

2.36e-05200765a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

PCSK5 FLNA PPP1R12B PLXNA4 TNXB

2.36e-0520076502cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_ALM_Olfr111_Nxph1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 DLG5 SHB CDH18

5.68e-05122764dba1c647172a11381efcb178a23808161908daa3
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rxfp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 DLG5 SHB CDH18

7.49e-0513176481efe8b0ca4377e557a42ddb12aecaf3f46b15bf
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_P2ry12|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 GDF5 DLG5 CDH18

7.49e-0513176480630812f8894b9358d36dc2dd03fea7ee870502
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Crh|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 DLG5 SHB CDH18

8.66e-0513676444f03e4f55fb2c5f8b9397142c89f7194b009cc6
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6b|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 DLG5 SHB CDH18

9.68e-0514076417005ca714ba03d7528fe7979ffb4654a46b666c
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 DLG5 SHB CDH18

9.95e-051417645ef3166c5271aa90fd0633016edfe2c74b835319
ToppCellCOVID-19-Heart-Adipocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLXNA4 TLN2 CDH4 GFRA1

1.36e-0415376493958bd9c951222ba5b740d1cb83fd5d78a10e1e
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DSCAM TNXB XRCC6 DNAH11

1.58e-041597647ed659163f45e0c4df4782997c0786900c8186c8
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 PTPRM DAAM2 CDH4

1.62e-04160764dd16ca90feb3ae88b6409d6c278b4765da565514
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

FLNA PPP1R12B PLXNA4 DNAH11

1.74e-041637641e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF5A MMP15 GFRA1 POLR3G

1.78e-0416476457301178e420983c0cb72178e288a3a0449fdda3
ToppCellSevere-CD8+_T|World / Disease group and Cell class

PTPRM PECAM1 DSCAML1

1.79e-04647633e7ede6ec5d8b9c4fc6f3aa8fda91fd9b763ef18
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPRM PECAM1 ZNF76 SREK1

1.82e-0416576462457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERICH3 PLXNA4 TLN2 MMP15

1.91e-04167764f4943fb5001475ddab82a0273bcbb3fa68fdd7bd
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHB CCDC180 CDH4 DSCAML1

1.95e-04168764ca65321259711321c175ede67bd67a47aad81d7a
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

ITPKC ABR TNXB GFRA1

2.00e-0416976484b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PPP1R12B DAAM2 TLN2 TNXB

2.28e-041757641799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 PECAM1 PLEC TNNI1

2.33e-0417676477516048aefbe1f48e825052756df0c310c1c486
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 PECAM1 PLEC TNNI1

2.33e-0417676496779273b94345250cf53ba671203345b43d9e00
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM PECAM1 LRP5 MMP15

2.43e-0417876493ce73f8bcec63ebf86fabb546f88400e8f06465
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR3 SCRN1 MAP3K15 GFRA1

2.43e-0417876430ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FURIN SHB LRP5 TNNI1

2.49e-04179764906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PLXNA4 DAAM2 TNXB

2.49e-0417976402c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CELSR3 ZNF76 DHX32 CLUH

2.54e-04180764c72f15763ba707189e29c85db533557f01c7fdb1
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLXNA4 DAAM2 TLN2 GFRA1

2.54e-0418076401f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GDF5 FLNA PPP1R12B GFRA1

2.59e-04181764beb2771820956be8b190c0088ae3c4efdb53c897
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GDF5 FLNA PPP1R12B GFRA1

2.65e-041827647b86703559438e2d5ef3dad963ee0d772513f313
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLN2 KIF5A DSCAML1 DNAH11

2.76e-041847642cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGPEP1L EPPK1 CCDC180 DNAH11

2.76e-04184764264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLN2 KIF5A DSCAML1 DNAH11

2.76e-04184764ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLN2 KIF5A DSCAML1 DNAH11

2.76e-041847642b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGPEP1L EPPK1 CCDC180 DNAH11

2.76e-04184764d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGPEP1L EPPK1 CCDC180 DNAH11

2.76e-0418476422010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PLXNA4 DAAM2 TNXB

2.82e-041857646712512100ccef456d2e2bd201d0987986c92ac9
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PLXNA4 DAAM2 TNXB

2.82e-041857643b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 DLG5 PPP1R12B PLXNA4

2.82e-04185764e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

ZC3H13 LTN1 TAF1 FAM83B

2.88e-0418676403db813598b67b1e08f759758a1c2023396921fa
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERICH3 EPPK1 CCDC180 DNAH11

2.94e-0418776404dba2ed09ee4180830bdf0191921696697ea234
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRM PECAM1 CD109 TNXB

2.94e-0418776435c382c0aabd46906113e5db30ea24bb8e658899
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IFT140 PTPRM CD109 CCDC180

2.94e-041877643699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IFT140 PTPRM CD109 CCDC180

2.94e-04187764033ba52c0c2f9978784947098fa697368ae44834
ToppCellfacs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERICH3 EPPK1 CCDC180 DNAH11

2.94e-04187764805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCellnormal_Lung-Myeloid_cells-pDCs|normal_Lung / Location, Cell class and cell subclass

KIAA0930 ATAD2B PLXNA4 DSCAML1

2.94e-04187764d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

DAAM2 TLN2 TNXB GFRA1

2.94e-04187764bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

MAP3K15 DSCAML1 WNK4 FAM83B

3.00e-041887641d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 ABR PECAM1 CD109

3.00e-04188764c2c51c6526defe2600302901159b8abbb58d7595
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNA PPP1R12B DAAM2 DNAH11

3.00e-04188764879de94924de978478696fc7838e05a4d795b905
ToppCellfacs-Skin-nan-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKB2 CASP4 FAM110A CDH4

3.06e-041897646c71e81373cb7822de23c193a6350b6df9f567bc
ToppCelldroplet-Kidney-nan-21m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PTPRM PECAM1 MMP15

3.06e-041897642ce330d8078833c05775c481e73770f9ee4a5c88
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNA PPP1R12B DAAM2 DNAH11

3.06e-04189764ab7ece0a517499b70b7754720d3e434765363af6
ToppCellfacs-Lung-24m-Epithelial-airway_epithelial-lung_ciliated_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPPK1 CCDC180 GFRA1 DNAH11

3.06e-041897641c28ad1263891d963e483b6847d8e89cc1b2d07e
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 PECAM1 PLEC TNNI1

3.06e-04189764feedac2751ed770f80bc56fec31662b5b3826f58
ToppCellfacs-Lung-24m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPPK1 CCDC180 GFRA1 DNAH11

3.06e-0418976400b20c2ed7876486c8e42e3a5b13023f44987a34
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABR PTPRM PECAM1 CD109

3.06e-0418976412b6f1c3bf526b90e112374bf937701f645c5780
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITPKC CASP4 CDH4 TNXB

3.06e-041897641cfc1fe27c4b57b4e52700fa8f679ce172cee5a9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 ABR PECAM1 CD109

3.06e-041897646463890d8dbee4bc198f91628a5f784970de786a
ToppCelldroplet-Kidney-nan-21m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PTPRM PECAM1 MMP15

3.06e-04189764473c87036e04a058b4a5138438b7ba7e1e766799
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 PLXNA4 DAAM2 GFRA1

3.06e-0418976445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
DrugL 744832

KRAS NRAS HRAS

1.43e-074763ctd:C096898
DrugAC1L32OA

KRAS NRAS HRAS

2.96e-069763CID000107745
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A

KIAA0930 NFKB2 SHB HRAS BYSL LRP5 PLEC

3.76e-061937671644_DN
Drugtrifluoperazine dihydrochloride; Down 200; 10uM; HL60; HT_HG-U133A

KRAS IFT140 KIAA0930 PPP1R12B CASP4 TLN2 ZNF76

3.89e-061947672684_DN
Drugisoprene

KRAS HRAS

1.10e-052762ctd:C005059
DrugTetranitromethane

KRAS HRAS

3.29e-053762ctd:D013774
DrugGGTI 2147

KRAS NRAS

3.29e-053762ctd:C466792
DrugLY 294002; Up 200; 10uM; HL60; HT_HG-U133A

PCSK5 GDF5 DSCAM PPP1R12B SHB TLN2

4.72e-051947666195_UP
Drug(-)-Eseroline fumarate salt [104015-29-4]; Down 200; 12uM; MCF7; HT_HG-U133A

IFT140 FURIN LRP5 TLN2 TMEM104 TAF1

5.00e-051967667027_DN
Druggenistein; Up 200; 10uM; MCF7; HT_HG-U133A

PLXNA3 EPPK1 CELSR2 LRP5 TMEM104 MMP15

5.00e-051967665232_UP
DrugBetulinic acid [472-15-1]; Down 200; 8.8uM; PC3; HT_HG-U133A

KRAS IFT140 ARR3 NFKB2 ZNF76 TAF1

5.00e-051967664101_DN
DrugBupropion hydrochloride [31677-93-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A

IFT140 DLG5 DDX17 FURIN TMEM104 MMP15

5.14e-051977663180_DN
DrugNiflumic acid [4394-00-7]; Up 200; 14.2uM; MCF7; HT_HG-U133A

IFT140 ITPKC DDX17 TLN2 ZNF76 MMP15

5.29e-051987667430_UP
DrugSulmazole [73384-60-8]; Up 200; 14uM; HL60; HT_HG-U133A

ARR3 ZC3H13 PPP1R12B NFKB2 ZNF76 PLEC

5.44e-051997662153_UP
DrugFlucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; HL60; HT_HG-U133A

CELSR2 DSCAM ZC3H13 ZNF76 PLEC POLR3G

5.44e-051997663128_DN
DrugGentamicine sulfate [1405-41-0]; Up 200; 2.6uM; PC3; HT_HG-U133A

ITPKC KIAA0930 ATAD2B CASP4 TLN2 CLUH

5.59e-052007662082_UP
DrugAminophylline [317-34-0]; Down 200; 9.6uM; HL60; HT_HG-U133A

IFT140 CELSR2 FURIN TLN2 ZNF76 POLR3G

5.59e-052007663036_DN
Drughelium;dihydroiodide

DDX17 NFKB2 TAF1

6.03e-0523763CID000437954
DiseaseVerrucous epidermal nevus

KRAS NRAS HRAS

1.64e-083763C0362030
DiseaseNevus Sebaceus of Jadassohn

KRAS NRAS HRAS

1.64e-083763C4552097
DiseaseOrganoid Nevus Phakomatosis

KRAS NRAS HRAS

1.64e-083763C0265329
DiseaseLinear nevus sebaceous syndrome

KRAS NRAS HRAS

1.64e-083763cv:C4552097
DiseaseNevus sebaceous

KRAS NRAS HRAS

1.64e-083763C3854181
DiseaseInflammatory linear verrucous epidermal nevus

KRAS NRAS HRAS

1.64e-083763C0473574
DiseaseSCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME

KRAS NRAS HRAS

1.64e-083763163200
Diseaselinear nevus sebaceous syndrome (is_implicated_in)

KRAS NRAS HRAS

1.64e-083763DOID:0111530 (is_implicated_in)
DiseaseNoonan syndrome 3 (implicated_via_orthology)

KRAS NRAS HRAS

1.64e-083763DOID:0060581 (implicated_via_orthology)
DiseaseLinear Verrucous Epidermal Nevus

KRAS NRAS HRAS

1.64e-083763C3179502
Diseasecervical cancer (implicated_via_orthology)

KRAS NRAS HRAS

1.64e-083763DOID:4362 (implicated_via_orthology)
DiseaseNEVUS, EPIDERMAL (disorder)

KRAS NRAS HRAS

1.64e-075763C0334082
DiseaseFollicular thyroid carcinoma

KRAS NRAS HRAS

1.64e-075763C0206682
DiseaseHemimegalencephaly

KRAS NRAS HRAS

3.27e-076763C0431391
DiseaseRASopathy (implicated_via_orthology)

KRAS NRAS HRAS

1.36e-069763DOID:0080690 (implicated_via_orthology)
DiseaseNoonan Syndrome 1

KRAS NRAS HRAS

2.67e-0611763C4551602
DiseaseTurner Syndrome, Male

KRAS NRAS HRAS

2.67e-0611763C0041409
DiseaseFemale Pseudo-Turner Syndrome

KRAS NRAS HRAS

2.67e-0611763C1527404
Diseasekidney cancer (implicated_via_orthology)

KRAS NRAS HRAS

2.67e-0611763DOID:263 (implicated_via_orthology)
Diseaseheart disease (implicated_via_orthology)

KRAS NRAS HRAS TNNI1

2.81e-0638764DOID:114 (implicated_via_orthology)
DiseaseAdenocarcinoma of large intestine

KRAS NRAS HRAS MAP3K15 TAF1

5.05e-0696765C1319315
DiseaseRAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER

KRAS NRAS

6.55e-062762614470
DiseaseAutoimmune lymphoproliferative syndrome type 4

KRAS NRAS

6.55e-062762cv:C2674723
Diseaseautoimmune lymphoproliferative syndrome type 4 (is_implicated_in)

KRAS NRAS

6.55e-062762DOID:0110117 (is_implicated_in)
DiseaseMELANOCYTIC NEVUS SYNDROME, CONGENITAL

NRAS HRAS

6.55e-062762137550
DiseaseMelanocytic nevus

NRAS HRAS

6.55e-062762cv:C0027962
DiseaseRAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER

KRAS NRAS

6.55e-062762C2674723
Diseaselarge congenital melanocytic nevus (is_implicated_in)

NRAS HRAS

6.55e-062762DOID:0111359 (is_implicated_in)
DiseaseLarge congenital melanocytic nevus

NRAS HRAS

6.55e-062762cv:C1842036
DiseaseRASopathy

KRAS NRAS HRAS

7.31e-0615763cv:C5555857
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

KRAS NRAS HRAS

1.54e-0519763C3501846
DiseaseNoonan syndrome-like disorder with loose anagen hair

KRAS NRAS HRAS

1.54e-0519763C1843181
DiseaseCardio-facio-cutaneous syndrome

KRAS NRAS HRAS

1.54e-0519763C1275081
DiseaseCostello syndrome (disorder)

KRAS NRAS HRAS

1.54e-0519763C0587248
Diseaseleukemia (implicated_via_orthology)

KRAS NRAS HRAS

1.54e-0519763DOID:1240 (implicated_via_orthology)
DiseaseGIANT PIGMENTED HAIRY NEVUS

NRAS HRAS

1.96e-053762C1842036
DiseaseLEOPARD Syndrome

KRAS NRAS HRAS

2.44e-0522763C0175704
DiseaseNoonan Syndrome

KRAS NRAS HRAS

3.20e-0524763C0028326
Diseasecardiomyopathy (implicated_via_orthology)

KRAS NRAS HRAS TNNI1

3.46e-0571764DOID:0050700 (implicated_via_orthology)
DiseaseNEVUS, EPIDERMAL

NRAS HRAS

3.92e-054762162900
DiseaseMalignant neoplasm of penis

KRAS HRAS

3.92e-054762C0153601
DiseasePenile Neoplasms

KRAS HRAS

3.92e-054762C0030849
DiseaseNevus, Keratinocytic, Nonepidermolytic

NRAS HRAS

3.92e-054762C4011754
DiseaseBLADDER CANCER

KRAS HRAS

3.92e-054762109800
DiseaseEpidermal nevus

NRAS HRAS

3.92e-054762cv:C0334082
DiseaseMalignant tumor of urinary bladder

KRAS HRAS

3.92e-054762cv:C0005684
DiseaseThyroid cancer, nonmedullary, 2

NRAS HRAS

3.92e-054762cv:C4225426
DiseaseMalignant tumor of cervix

KRAS HRAS

3.92e-054762C0007847
Diseaseepidermal nevus (is_implicated_in)

NRAS HRAS

3.92e-054762DOID:0111162 (is_implicated_in)
DiseaseTHYROID CANCER, NONMEDULLARY, 2

NRAS HRAS

3.92e-054762188470
Diseasehypertrophic cardiomyopathy (implicated_via_orthology)

KRAS NRAS HRAS

5.72e-0529763DOID:11984 (implicated_via_orthology)
Diseasecolorectal cancer (implicated_via_orthology)

KRAS NRAS HRAS

6.34e-0530763DOID:9256 (implicated_via_orthology)
DiseaseTHYROID CANCER, NONMEDULLARY, 2

NRAS HRAS

6.51e-055762C4225426
DiseaseMalignant neoplasm of thyroid

KRAS NRAS

6.51e-055762C0007115
DiseaseCetuximab response

KRAS NRAS

6.51e-055762cv:CN077967
DiseaseCervix carcinoma

KRAS HRAS

6.51e-055762C0302592
DiseasePanitumumab response

KRAS NRAS

6.51e-055762cv:CN077999
Diseaseintestinal cancer (implicated_via_orthology)

KRAS NRAS HRAS

7.72e-0532763DOID:10155 (implicated_via_orthology)
Diseaseprostate cancer (implicated_via_orthology)

KRAS NRAS HRAS

8.47e-0533763DOID:10283 (implicated_via_orthology)
DiseasePleocytosis

KRAS NRAS

9.75e-056762C0151857
DiseaseAutoimmune lymphoproliferative syndrome

KRAS NRAS

9.75e-056762cv:CN301239
DiseaseCarcinoma in situ of uterine cervix

KRAS HRAS

9.75e-056762C0851140
Diseaseseminoma (is_implicated_in)

KRAS HRAS

9.75e-056762DOID:4440 (is_implicated_in)
DiseaseLeukocytosis

KRAS NRAS

9.75e-056762C0023518
DiseaseThyroid Neoplasm

KRAS NRAS HRAS

1.20e-0437763C0040136
DiseaseThyroid cancer, follicular

NRAS HRAS

1.36e-047762C2931367
DiseaseAlzheimer's disease biomarker measurement, brain volume measurement

KRAS NRAS

1.81e-048762EFO_0006514, EFO_0006930
Diseasegdnf family receptor alpha-1 measurement

TNXB GFRA1

1.81e-048762EFO_0020400
DiseaseAdenocarcinoma of lung (disorder)

KRAS NRAS HRAS MAP3K15 XRCC6

1.95e-04206765C0152013
Diseasehigh grade glioma (implicated_via_orthology)

KRAS NRAS HRAS

2.02e-0444763DOID:3070 (implicated_via_orthology)
DiseaseThyroid carcinoma

KRAS NRAS HRAS

2.02e-0444763C0549473
DiseaseNoonan syndrome

KRAS NRAS

2.33e-049762cv:C0028326
DiseaseNeuroblastoma

KRAS NRAS HRAS

2.45e-0447763C0027819
DiseaseAlzheimer's disease biomarker measurement

KRAS PCSK5 NRAS

2.61e-0448763EFO_0006514
Diseasethyroid gland papillary carcinoma (is_implicated_in)

NRAS HRAS

2.91e-0410762DOID:3969 (is_implicated_in)
Diseaseentorhinal cortical volume, Alzheimer's disease biomarker measurement

KRAS NRAS

3.55e-0411762EFO_0005092, EFO_0006514
DiseaseMetastatic melanoma

MAP3K15 TAF1 WNK4

3.71e-0454763C0278883
Diseasemiddle temporal gyrus volume measurement, Alzheimer's disease biomarker measurement

KRAS NRAS

5.01e-0413762EFO_0006514, EFO_0010316
Diseaseserum gamma-glutamyl transferase measurement

KRAS DLG5 NRAS CELSR2 PTPRM PDX1 KDM2B MICAL3 MMP15

5.61e-04914769EFO_0004532
Diseasetransitional cell carcinoma (is_marker_for)

KRAS NRAS MMP15

5.83e-0463763DOID:2671 (is_marker_for)
Diseasewhole-brain volume, Alzheimer's disease biomarker measurement

KRAS NRAS

5.84e-0414762EFO_0005089, EFO_0006514
Diseasecarcinoma (implicated_via_orthology)

KRAS NRAS HRAS

6.11e-0464763DOID:305 (implicated_via_orthology)
DiseaseNeoplasms, Experimental

KRAS NRAS HRAS

6.69e-0466763C0027659
DiseaseDown syndrome (implicated_via_orthology)

DSCAM DSCAML1

6.73e-0415762DOID:14250 (implicated_via_orthology)
DiseaseT-Cell Lymphoma

HRAS MGA

7.67e-0416762C0079772
Diseasediabetic retinopathy (implicated_via_orthology)

HRAS PDX1

7.67e-0416762DOID:8947 (implicated_via_orthology)
Diseasedysmenorrheic pain measurement

KRAS NRAS

7.67e-0416762EFO_0007889
DiseaseVan Buchem disease

FLNA LRP5

8.68e-0417762C0432272
DiseaseHemangiosarcoma

KRAS HRAS

9.75e-0418762C0018923
Diseasehippocampal volume

EPPK1 PTPRM PLEC DSCAML1 DNAH11

1.03e-03297765EFO_0005035
Diseasehair colour measurement

KRAS KIAA0930 NRAS SHB ALKBH3 LRP5 ZNF76

1.04e-03615767EFO_0007822
DiseaseDisproportionate short stature

GDF5 FLNA IFT140

1.05e-0377763C0878659
DiseaseJuvenile Myelomonocytic Leukemia

KRAS NRAS

1.09e-0319762C0349639
Diseasecalcium measurement

KRAS NRAS CELSR2 CD109 ZNF318 KIF5A PLEC

1.18e-03628767EFO_0004838
DiseaseFEV/FEC ratio

PCSK5 ABR PTPRM SHB MICAL3 TNNI1 MMP15 MGA TNXB FAM83B

1.18e-0312287610EFO_0004713
Diseasebase metabolic rate measurement

GDF5 MICAL3

1.21e-0320762EFO_0007777
DiseasePapillary thyroid carcinoma

KRAS NRAS HRAS

1.44e-0386763C0238463
DiseaseHMG CoA reductase inhibitor use measurement

CELSR2 FURIN PLEC DNAH11

1.46e-03189764EFO_0009932
DiseaseSplenomegaly

KRAS NRAS

1.46e-0322762C0038002
Diseasetriacylglycerol 58:9 measurement

NFKB2 TNXB

1.46e-0322762EFO_0010443

Protein segments in the cluster

PeptideGeneStartEntry
ERSKVPYIVRQCVEE

ABR

656

Q12979
VRKEREYVIPKRNEI

ERICH3

431

Q5RHP9
RAEEIYPIKERNNRT

CASP4

121

P49662
DREFVFKEPQQVVRR

ALKBH3

51

Q96Q83
RKINEARECYRPVAA

DNAH11

3696

Q96DT5
EKRFEIQRYLSTPER

BSX

126

Q3C1V8
EKRYVVQVREDVTPG

CELSR2

401

Q9HCU4
IKYRQTTQDAPEEVR

CWC15

41

Q9P013
VAEEFYRKEKRPVTR

CCDC180

1391

Q9P1Z9
PLDETEKRCQVYQRR

DHX32

321

Q7L7V1
PEETVSKRDYVRLVV

ARR3

151

P36575
YREQIKRVKDSDDVP

HRAS

96

P01112
YREQIKRVKDSEDVP

KRAS

96

P01116
YREQIKRVKDSDDVP

NRAS

96

P01111
TYLEEELVKARERPR

ITPKC

491

Q96DU7
TVPEEEREAKFYRVV

LTN1

211

O94822
KFVCEYRRPVAERAQ

ANO7

746

Q6IWH7
EYQRRQVREPSDKFV

DAAM2

896

Q86T65
KSRREPRTYTEEELN

MICAL3

1811

Q7RTP6
DDRGPVVRKQRYVFD

GDF5

211

P43026
VRVYERKKEDQRQPS

MGA

1241

Q8IWI9
YRDAEIVRTRDPEKL

MYG1

71

Q9HB07
EVLYIQRPIEEDRRK

ATAD2B

891

Q9ULI0
SQDYRVVAAQRKEEP

ATXN1L

346

P0C7T5
EVPYEDIRLRRQKEA

MMP15

181

P51511
RDKPRAIVVNAERGY

LRP5

1066

O75197
RKAAEPEVEVEVYRR

KIAA0930

71

Q6ICG6
YRDSREINAVVTPER

FAM83B

896

Q5T0W9
KVERFRYSRVEDPTD

PCSK5

611

Q92824
AEPEENKRTRTAYTR

PDX1

141

P52945
VQEPRVRAKYRGIET

PLXNA3

1051

P51805
RDLEVPGYRQERVEK

PLXNA4

1336

Q9HCM2
ELPVDYREAKRRVTG

PGPEP1L

26

A6NFU8
VRKAVPDAVESRYSR

PECAM1

716

P16284
VEERARERVPYGVSV

FAM110A

256

Q9BQ89
RERVPYGVSVVERNA

FAM110A

261

Q9BQ89
RDGVRLKVQYRPEEF

DLG5

1571

Q8TDM6
EPRRQAVRSYNSEVK

CD109

1386

Q6YHK3
IYEIEDRTRVQPKFR

KDM2B

341

Q8NHM5
RQTIVPVCSYEEREK

GFRA1

226

P56159
AVFREPYTVRVEDQR

DSCAML1

121

Q8TD84
TEIDQDKYAVRFIPR

FLNA

2381

P21333
AKRRTKRDVYQEPTD

FURIN

101

P09958
VRIRSDKDNDIPIRY

CDH4

191

P55283
AAEELKYRRDIRPEV

CDH18

681

Q13634
VVRIAPEERQKYEEE

KIF5A

406

Q12840
VARLTPYEVDELRRK

DDX17

141

Q92841
SEKRYVAQVREDVRP

CELSR3

546

Q9NYQ7
RFIQARRTYTEDPKE

IFT140

1341

Q96RY7
PRVRDDVAEYKRLNF

BYSL

256

Q13895
YQIVVEEERPRRTKK

PTPRM

621

P28827
VRIAIKEIPERDSRY

MAP3K15

676

Q6ZN16
VLREPYTVRVEDQKT

DSCAM

121

O60469
REPVSDYQVLREKAA

TAF8

166

Q7Z7C8
IRAYRAQKERDFEDP

SHB

81

Q15464
RENVRKRLYPSREEF

TAF1

1431

P21675
RYDDEVKRVVAEPVE

NDUFS3

211

O75489
EKVSYRELQERCRPQ

EPPK1

2061

P58107
VDPSKIDEIRRTVYV

SREK1

56

Q8WXA9
KNSARPRDEVQEVVY

SCRN1

26

Q12765
LRVVEEPYTVREARI

CLUH

116

O75153
EKEVAALCRYTPRRN

XRCC6

391

P12956
TVQYKDRDGRPQVVR

TNXB

2126

P22105
RDNYERAEKRPILSV

TMEM104

101

Q8NE00
EREAEKVRYLAERIP

TNNI1

36

P19237
VVPERDRKEVYDDVL

PRPF40B

381

Q6NWY9
ETPEERQDIERYSKR

POLR3G

76

O15318
ERVREYSQKVLERQP

TTC9C

91

Q8N5M4
EQRVYRRKELEEVSP

PLEC

136

Q15149
TQVPETREVYKSEDR

ZNF655

81

Q8N720
AVYDACRVIRERVPE

TLN2

26

Q9Y4G6
ERSREAKRPRYDDTV

ZNF318

266

Q5VUA4
ADYQPVARAVRERVA

WNK4

501

Q96J92
RPRIAYLSEVKEERD

ZNF76

401

P36508
PERKESSRRYEEQEL

ZC3H13

896

Q5T200
VYESRRVTDPERQDL

THEG

36

Q9P2T0
EAREKRRSYLTPVRD

PPP1R12B

611

O60237
YPLVEDKEEVQRKRR

NFKB2

326

Q00653