Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	receptor ligand activity	CCN6 CCN2 FBN1 EGF WNT1 WNT2 WNT10B	3.15e-05	547	34	7	GO:0048018
GeneOntologyMolecularFunction	signaling receptor activator activity	CCN6 CCN2 FBN1 EGF WNT1 WNT2 WNT10B	3.42e-05	554	34	7	GO:0030546
GeneOntologyMolecularFunction	frizzled binding	WNT1 WNT2 WNT10B	4.95e-05	42	34	3	GO:0005109
GeneOntologyMolecularFunction	metalloendopeptidase activity	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	5.00e-05	120	34	4	GO:0004222
GeneOntologyMolecularFunction	signaling receptor regulator activity	CCN6 CCN2 FBN1 EGF WNT1 WNT2 WNT10B	6.69e-05	616	34	7	GO:0030545
GeneOntologyMolecularFunction	integrin binding	ITGA10 CCN6 CCN2 FBN1	2.15e-04	175	34	4	GO:0005178
GeneOntologyMolecularFunction	extracellular matrix structural constituent	THSD4 HSPG2 FBN1 HMCN1	2.83e-04	188	34	4	GO:0005201
GeneOntologyMolecularFunction	heparin binding	CCN6 APLP1 CCN2 FBN1	3.07e-04	192	34	4	GO:0008201
GeneOntologyMolecularFunction	metallopeptidase activity	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	3.58e-04	200	34	4	GO:0008237
GeneOntologyMolecularFunction	glycosaminoglycan binding	CCN6 APLP1 CCN2 FBN1	1.07e-03	268	34	4	GO:0005539
GeneOntologyMolecularFunction	fibronectin binding	CCN2 MMP2	1.90e-03	38	34	2	GO:0001968
GeneOntologyMolecularFunction	sulfur compound binding	CCN6 APLP1 CCN2 FBN1	2.13e-03	323	34	4	GO:1901681
GeneOntologyMolecularFunction	G protein-coupled receptor binding	APLP1 WNT1 WNT2 WNT10B	2.48e-03	337	34	4	GO:0001664
GeneOntologyMolecularFunction	growth factor activity	CCN6 CCN2 EGF	3.14e-03	173	34	3	GO:0008083
GeneOntologyMolecularFunction	molecular function activator activity	CCN6 CCN2 FBN1 EGF WNT1 WNT2 WNT10B	4.15e-03	1233	34	7	GO:0140677
GeneOntologyMolecularFunction	endopeptidase activity	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	5.90e-03	430	34	4	GO:0004175
GeneOntologyMolecularFunction	collagen binding	ITGA10 HSPG2	8.38e-03	81	34	2	GO:0005518
GeneOntologyMolecularFunction	cytokine activity	WNT1 WNT2 WNT10B	8.72e-03	250	34	3	GO:0005125
GeneOntologyMolecularFunction	cargo receptor activity	HAVCR1 SORL1	9.20e-03	85	34	2	GO:0038024
GeneOntologyBiologicalProcess	extracellular matrix organization	ADAMTS17 THSD4 HSPG2 APLP1 CCN2 MMP2 HMCN1 ADAMTS7 ADAMTS9	5.42e-09	377	33	9	GO:0030198
GeneOntologyBiologicalProcess	extracellular structure organization	ADAMTS17 THSD4 HSPG2 APLP1 CCN2 MMP2 HMCN1 ADAMTS7 ADAMTS9	5.55e-09	378	33	9	GO:0043062
GeneOntologyBiologicalProcess	external encapsulating structure organization	ADAMTS17 THSD4 HSPG2 APLP1 CCN2 MMP2 HMCN1 ADAMTS7 ADAMTS9	5.67e-09	379	33	9	GO:0045229
GeneOntologyBiologicalProcess	negative regulation of cellular response to growth factor stimulus	SPRY3 FBN1 WNT1 SPRY4 SORL1	3.83e-06	150	33	5	GO:0090288
GeneOntologyBiologicalProcess	skeletal system development	HSPG2 CCN2 FBN1 MMP2 ADAMTS7 WNT1 WNT10B	4.40e-05	615	33	7	GO:0001501
GeneOntologyBiologicalProcess	cell proliferation in midbrain	WNT1 WNT2	6.91e-05	8	33	2	GO:0033278
GeneOntologyBiologicalProcess	negative regulation of developmental process	CCN6 SPRY3 HSPG2 FBN1 ADAMTS7 ADAMTS9 WNT1 WNT10B SORL1	9.10e-05	1220	33	9	GO:0051093
GeneOntologyBiologicalProcess	regulation of protein localization to early endosome	EGF SORL1	1.11e-04	10	33	2	GO:1902965
GeneOntologyBiologicalProcess	positive regulation of protein localization to early endosome	EGF SORL1	1.11e-04	10	33	2	GO:1902966
GeneOntologyBiologicalProcess	positive regulation of hematopoietic stem cell proliferation	WNT1 WNT10B	1.11e-04	10	33	2	GO:1902035
GeneOntologyBiologicalProcess	cell surface receptor protein tyrosine kinase signaling pathway	SPRY3 CCN2 MMP2 EGF WNT1 SPRY4 SORL1	1.49e-04	747	33	7	GO:0007169
GeneOntologyBiologicalProcess	negative regulation of fat cell differentiation	FBN1 WNT1 WNT10B	1.90e-04	70	33	3	GO:0045599
GeneOntologyBiologicalProcess	bone trabecula formation	MMP2 WNT10B	2.23e-04	14	33	2	GO:0060346
GeneOntologyBiologicalProcess	positive regulation of protein localization to endosome	EGF SORL1	2.23e-04	14	33	2	GO:1905668
GeneOntologyBiologicalProcess	regulation of protein localization to endosome	EGF SORL1	2.57e-04	15	33	2	GO:1905666
GeneOntologyBiologicalProcess	tube development	CCN6 HSPG2 CCN2 FBN1 MMP2 EGF ADAMTS9 WNT1 WNT2	2.62e-04	1402	33	9	GO:0035295
GeneOntologyBiologicalProcess	negative regulation of BMP signaling pathway	FBN1 WNT1 SORL1	2.82e-04	80	33	3	GO:0030514
GeneOntologyBiologicalProcess	protein localization to early endosome	EGF SORL1	2.94e-04	16	33	2	GO:1902946
GeneOntologyBiologicalProcess	tube morphogenesis	CCN6 HSPG2 CCN2 MMP2 EGF ADAMTS9 WNT1 WNT2	3.12e-04	1125	33	8	GO:0035239
GeneOntologyBiologicalProcess	cellular response to growth factor stimulus	SPRY3 CCN2 FBN1 ADAMTS7 WNT1 SPRY4 SORL1	3.29e-04	850	33	7	GO:0071363
GeneOntologyBiologicalProcess	positive regulation of fibroblast proliferation	EGF WNT1 WNT2	3.37e-04	85	33	3	GO:0048146
GeneOntologyBiologicalProcess	response to BMP	FBN1 ADAMTS7 WNT1 SORL1	3.71e-04	215	33	4	GO:0071772
GeneOntologyBiologicalProcess	cellular response to BMP stimulus	FBN1 ADAMTS7 WNT1 SORL1	3.71e-04	215	33	4	GO:0071773
GeneOntologyBiologicalProcess	midbrain dopaminergic neuron differentiation	WNT1 WNT2	3.74e-04	18	33	2	GO:1904948
GeneOntologyBiologicalProcess	bone trabecula morphogenesis	MMP2 WNT10B	3.74e-04	18	33	2	GO:0061430
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	CCN6 HSPG2 CCN2 MMP2 EGF ADAMTS9 WNT1 WNT2 WNT10B	3.98e-04	1483	33	9	GO:0048646
GeneOntologyBiologicalProcess	response to growth factor	SPRY3 CCN2 FBN1 ADAMTS7 WNT1 SPRY4 SORL1	4.14e-04	883	33	7	GO:0070848
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	SPRY3 CCN2 FBN1 MMP2 EGF WNT1 SPRY4 SORL1	4.46e-04	1186	33	8	GO:0007167
GeneOntologyBiologicalProcess	cell-substrate adhesion	ITGA10 CCN2 ADAMTS9 WNT1 SPRY4	4.54e-04	410	33	5	GO:0031589
GeneOntologyBiologicalProcess	positive regulation of cell population proliferation	CNBP HSPG2 CCN2 MMP2 EGF WNT1 WNT2 WNT10B	4.56e-04	1190	33	8	GO:0008284
GeneOntologyBiologicalProcess	regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	MMP2 WNT1	4.63e-04	20	33	2	GO:1903376
GeneOntologyBiologicalProcess	regulation of hematopoietic stem cell proliferation	WNT1 WNT10B	4.63e-04	20	33	2	GO:1902033
GeneOntologyBiologicalProcess	regulation of cellular response to growth factor stimulus	SPRY3 FBN1 WNT1 SPRY4 SORL1	4.64e-04	412	33	5	GO:0090287
GeneOntologyBiologicalProcess	fibroblast growth factor receptor signaling pathway	SPRY3 CCN2 SPRY4	5.12e-04	98	33	3	GO:0008543
GeneOntologyBiologicalProcess	head development	HSPG2 APLP1 MMP2 EGF WNT1 WNT2 GPX4	5.26e-04	919	33	7	GO:0060322
GeneOntologyBiologicalProcess	blood vessel development	CCN6 HSPG2 CCN2 MMP2 EGF ADAMTS9 WNT2	5.62e-04	929	33	7	GO:0001568
GeneOntologyBiologicalProcess	neuron intrinsic apoptotic signaling pathway in response to oxidative stress	MMP2 WNT1	5.62e-04	22	33	2	GO:0036480
GeneOntologyBiologicalProcess	lens development in camera-type eye	CRYGD ADAMTS9 WNT2	5.92e-04	103	33	3	GO:0002088
GeneOntologyBiologicalProcess	regeneration	HSPG2 MMP2 WNT1 WNT10B	6.74e-04	252	33	4	GO:0031099
GeneOntologyBiologicalProcess	animal organ morphogenesis	HSPG2 APLP1 CCN2 MMP2 ADAMTS9 WNT1 WNT2 WNT10B	6.99e-04	1269	33	8	GO:0009887
GeneOntologyBiologicalProcess	vasculature development	CCN6 HSPG2 CCN2 MMP2 EGF ADAMTS9 WNT2	7.22e-04	969	33	7	GO:0001944
GeneOntologyBiologicalProcess	bone development	HSPG2 FBN1 ADAMTS7 WNT1	8.02e-04	264	33	4	GO:0060348
GeneOntologyBiologicalProcess	angiogenesis	CCN6 HSPG2 CCN2 MMP2 EGF ADAMTS9	8.03e-04	708	33	6	GO:0001525
GeneOntologyBiologicalProcess	negative regulation of fibroblast growth factor receptor signaling pathway	SPRY3 SPRY4	8.50e-04	27	33	2	GO:0040037
GeneOntologyBiologicalProcess	negative regulation of Ras protein signal transduction	SPRY3 SPRY4	9.14e-04	28	33	2	GO:0046580
GeneOntologyBiologicalProcess	skeletal system morphogenesis	HSPG2 CCN2 MMP2 WNT10B	9.58e-04	277	33	4	GO:0048705
GeneOntologyBiologicalProcess	cellular response to fibroblast growth factor stimulus	SPRY3 CCN2 SPRY4	1.01e-03	124	33	3	GO:0044344
GeneOntologyBiologicalProcess	positive regulation of endothelial cell proliferation	HSPG2 EGF WNT2	1.04e-03	125	33	3	GO:0001938
GeneOntologyBiologicalProcess	regulation of BMP signaling pathway	FBN1 WNT1 SORL1	1.19e-03	131	33	3	GO:0030510
GeneOntologyBiologicalProcess	response to retinoic acid	MMP2 WNT2 WNT10B	1.19e-03	131	33	3	GO:0032526
GeneOntologyBiologicalProcess	trabecula formation	MMP2 WNT10B	1.19e-03	32	33	2	GO:0060343
GeneOntologyBiologicalProcess	response to fibroblast growth factor	SPRY3 CCN2 SPRY4	1.21e-03	132	33	3	GO:0071774
GeneOntologyBiologicalProcess	chondrocyte differentiation	HSPG2 CCN2 ADAMTS7	1.24e-03	133	33	3	GO:0002062
GeneOntologyBiologicalProcess	protein localization to endosome	EGF SORL1	1.27e-03	33	33	2	GO:0036010
GeneOntologyBiologicalProcess	regulation of fibroblast proliferation	EGF WNT1 WNT2	1.30e-03	135	33	3	GO:0048145
GeneOntologyBiologicalProcess	circulatory system development	CCN6 HSPG2 CCN2 FBN1 MMP2 EGF ADAMTS9 WNT2	1.61e-03	1442	33	8	GO:0072359
GeneOntologyBiologicalProcess	cellular response to oxygen-containing compound	APLP1 CRYGD FBN1 MMP2 WNT1 WNT2 WNT10B SORL1	1.66e-03	1450	33	8	GO:1901701
GeneOntologyBiologicalProcess	blood vessel morphogenesis	CCN6 HSPG2 CCN2 MMP2 EGF ADAMTS9	1.68e-03	817	33	6	GO:0048514
GeneOntologyBiologicalProcess	ossification	HSPG2 CCN2 MMP2 ADAMTS7 WNT10B	1.86e-03	562	33	5	GO:0001503
GeneOntologyBiologicalProcess	developmental induction	WNT1 WNT2	1.96e-03	41	33	2	GO:0031128
GeneOntologyBiologicalProcess	negative regulation of multicellular organismal process	CCN6 HSPG2 FBN1 MMP2 ADAMTS7 ADAMTS9 WNT10B SORL1	1.96e-03	1488	33	8	GO:0051241
GeneOntologyBiologicalProcess	connective tissue development	HSPG2 CCN2 ADAMTS7 SORL1	2.10e-03	343	33	4	GO:0061448
GeneOntologyBiologicalProcess	fibroblast proliferation	EGF WNT1 WNT2	2.11e-03	160	33	3	GO:0048144
GeneOntologyBiologicalProcess	canonical Wnt signaling pathway	EGF WNT1 WNT2 WNT10B	2.12e-03	344	33	4	GO:0060070
GeneOntologyBiologicalProcess	hematopoietic stem cell proliferation	WNT1 WNT10B	2.15e-03	43	33	2	GO:0071425
GeneOntologyBiologicalProcess	brain development	HSPG2 APLP1 EGF WNT1 WNT2 GPX4	2.17e-03	859	33	6	GO:0007420
GeneOntologyBiologicalProcess	regulation of fibroblast growth factor receptor signaling pathway	SPRY3 SPRY4	2.25e-03	44	33	2	GO:0040036
GeneOntologyBiologicalProcess	anatomical structure maturation	MMP2 ADAMTS7 WNT1 WNT10B	2.36e-03	354	33	4	GO:0071695
GeneOntologyBiologicalProcess	regulation of fat cell differentiation	FBN1 WNT1 WNT10B	2.42e-03	168	33	3	GO:0045598
GeneOntologyBiologicalProcess	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	MMP2 WNT1	2.57e-03	47	33	2	GO:1902175
GeneOntologyBiologicalProcess	negative regulation of angiogenesis	CCN6 HSPG2 ADAMTS9	2.72e-03	175	33	3	GO:0016525
GeneOntologyBiologicalProcess	negative regulation of blood vessel morphogenesis	CCN6 HSPG2 ADAMTS9	2.85e-03	178	33	3	GO:2000181
GeneOntologyBiologicalProcess	dopaminergic neuron differentiation	WNT1 WNT2	2.90e-03	50	33	2	GO:0071542
GeneOntologyBiologicalProcess	negative regulation of cell adhesion	HSPG2 MMP2 WNT1 SPRY4	2.90e-03	375	33	4	GO:0007162
GeneOntologyBiologicalProcess	negative regulation of vasculature development	CCN6 HSPG2 ADAMTS9	2.94e-03	180	33	3	GO:1901343
GeneOntologyBiologicalProcess	regulation of ubiquitin-dependent protein catabolic process	EGF WNT1 WNT10B	3.18e-03	185	33	3	GO:2000058
GeneOntologyCellularComponent	extracellular matrix	ADAMTS17 THSD4 CCN6 HSPG2 APLP1 CCN2 FBN1 MMP2 HMCN1 ADAMTS7 ADAMTS9 WNT2	3.56e-10	656	35	12	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ADAMTS17 THSD4 CCN6 HSPG2 APLP1 CCN2 FBN1 MMP2 HMCN1 ADAMTS7 ADAMTS9 WNT2	3.68e-10	658	35	12	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	ADAMTS17 THSD4 HSPG2 APLP1 CCN2 FBN1 MMP2 HMCN1 ADAMTS9 WNT2	1.05e-08	530	35	10	GO:0062023
GeneOntologyCellularComponent	basement membrane	HSPG2 APLP1 FBN1 HMCN1	5.03e-05	122	35	4	GO:0005604
GeneOntologyCellularComponent	microfibril	THSD4 FBN1	2.10e-04	13	35	2	GO:0001527
GeneOntologyCellularComponent	Wnt signalosome	WNT1 WNT2	3.22e-04	16	35	2	GO:1990909
HumanPheno	Protrusio acetabuli	HSPG2 FBN1 MMP2	1.23e-05	13	19	3	HP:0003179
HumanPheno	Abnormal acetabulum morphology	CCN6 HSPG2 FBN1 MMP2 GPX4	1.64e-05	92	19	5	HP:0003170
MousePheno	abnormal mandible morphology	CNBP HSPG2 CCN2 FBN1 MMP2 SPRY4	2.07e-06	176	31	6	MP:0000458
MousePheno	abnormal aortic sinus morphology	THSD4 FBN1	4.76e-06	2	31	2	MP:0010482
MousePheno	abnormal ascending aorta morphology	THSD4 HSPG2 FBN1	1.48e-05	22	31	3	MP:0009867
MousePheno	increased collagen level	ADAMTS17 ADAMTS7	2.85e-05	4	31	2	MP:0020253
MousePheno	decreased mesenchymal cell proliferation involved in lung development	CCN2 WNT2	4.74e-05	5	31	2	MP:0011148
MousePheno	abnormal cartilage morphology	ADAMTS17 ITGA10 HSPG2 CCN2 FBN1 MMP2	8.17e-05	336	31	6	MP:0000163
MousePheno	abnormal chest morphology	HSPG2 CCN2 FBN1	8.55e-05	39	31	3	MP:0004134
MousePheno	increased total lung capacity	FBN1 ADAMTS7	9.93e-05	7	31	2	MP:0010937
MousePheno	abnormal long bone hypertrophic chondrocyte zone	ADAMTS17 ITGA10 HSPG2 CCN2	1.08e-04	113	31	4	MP:0000165
MousePheno	small mandible	CNBP HSPG2 CCN2 MMP2	1.19e-04	116	31	4	MP:0004592
MousePheno	abnormal ethmoid bone morphology	HSPG2 CCN2	1.32e-04	8	31	2	MP:0000100
MousePheno	abnormal aorta bulb morphology	THSD4 FBN1	1.70e-04	9	31	2	MP:0011572
MousePheno	abnormal total lung capacity	FBN1 ADAMTS7	2.12e-04	10	31	2	MP:0002304
MousePheno	abnormal mesenchymal cell proliferation involved in lung development	CCN2 WNT2	2.12e-04	10	31	2	MP:0011146
MousePheno	abnormal hindlimb morphology	ADAMTS17 ITGA10 HSPG2 CCN2 FBN1 SPRY4 FRMPD1	2.16e-04	576	31	7	MP:0000556
MousePheno	decreased length of long bones	ADAMTS17 ITGA10 HSPG2 FBN1 MMP2 SPRY4	2.39e-04	409	31	6	MP:0004686
MousePheno	abnormal lung development	CCN2 FBN1 MMP2 WNT2	2.59e-04	142	31	4	MP:0001176
MousePheno	abnormal cranium morphology	ADAMTS17 CNBP HSPG2 CCN2 FBN1 MMP2 WNT1 SPRY4	3.01e-04	813	31	8	MP:0000438
MousePheno	abnormal craniofacial bone morphology	ADAMTS17 CNBP HSPG2 CCN2 FBN1 MMP2 WNT1 SPRY4	3.38e-04	827	31	8	MP:0002116
MousePheno	short mandible	HSPG2 CCN2 MMP2	3.75e-04	64	31	3	MP:0000088
MousePheno	abnormal respiratory system development	CCN2 FBN1 MMP2 WNT2	4.09e-04	160	31	4	MP:0003115
MousePheno	short metacarpal bones	ADAMTS17 FBN1	4.26e-04	14	31	2	MP:0004634
MousePheno	abnormal cartilage development	ADAMTS17 ITGA10 HSPG2 CCN2	5.37e-04	172	31	4	MP:0000164
MousePheno	abnormal long bone epiphyseal plate morphology	ADAMTS17 ITGA10 HSPG2 CCN2	5.37e-04	172	31	4	MP:0003055
MousePheno	decreased bone mineral density	CCN2 FBN1 MMP2 UHRF2 WNT10B FRMPD1	5.38e-04	476	31	6	MP:0000063
MousePheno	abnormal collagen level	ADAMTS17 ADAMTS7	5.60e-04	16	31	2	MP:0020252
MousePheno	abnormal long bone morphology	ADAMTS17 ITGA10 HSPG2 CCN2 FBN1 MMP2 SPRY4	5.70e-04	676	31	7	MP:0003723
MousePheno	abnormal forelimb morphology	ADAMTS17 HSPG2 CCN2 FBN1	6.64e-04	182	31	4	MP:0000550
MousePheno	abnormal epiphyseal plate morphology	ADAMTS17 ITGA10 HSPG2 CCN2	7.06e-04	185	31	4	MP:0006395
MousePheno	chondrodystrophy	HSPG2 CCN2	7.12e-04	18	31	2	MP:0002657
MousePheno	brachyphalangia	ADAMTS17 FBN1	7.95e-04	19	31	2	MP:0002543
MousePheno	abnormal jaw morphology	CNBP HSPG2 CCN2 FBN1 MMP2 SPRY4	9.47e-04	530	31	6	MP:0000454
MousePheno	abnormal cranium size	ADAMTS17 HSPG2 FBN1	1.26e-03	97	31	3	MP:0010031
MousePheno	abnormal tibia morphology	ADAMTS17 ITGA10 CCN2 FBN1 SPRY4	1.29e-03	375	31	5	MP:0000558
MousePheno	abnormal limb long bone morphology	ADAMTS17 ITGA10 HSPG2 CCN2 FBN1 SPRY4	1.35e-03	568	31	6	MP:0011504
MousePheno	increased interleukin-13 secretion	HAVCR1 FBN1	1.38e-03	25	31	2	MP:0008672
MousePheno	abnormal thoracic cavity morphology	CCN2 FBN1	1.38e-03	25	31	2	MP:0004733
MousePheno	disorganized long bone epiphyseal plate	HSPG2 CCN2	1.38e-03	25	31	2	MP:0006397
MousePheno	abnormal hindlimb zeugopod morphology	ADAMTS17 ITGA10 CCN2 FBN1 SPRY4	1.39e-03	381	31	5	MP:0003857
MousePheno	short facial bone	HSPG2 CCN2 MMP2	1.55e-03	104	31	3	MP:0030384
MousePheno	abnormal limb bone morphology	ADAMTS17 ITGA10 HSPG2 CCN2 FBN1 SPRY4	1.60e-03	587	31	6	MP:0002115
MousePheno	abnormal viscerocranium morphology	CNBP HSPG2 CCN2 FBN1 MMP2 SPRY4	1.69e-03	593	31	6	MP:0005274
MousePheno	dilated aorta	THSD4 FBN1	1.74e-03	28	31	2	MP:0010574
MousePheno	craniofacial phenotype	ADAMTS17 CNBP HSPG2 CCN2 FBN1 MMP2 WNT1 SPRY4 SORL1	2.25e-03	1372	31	9	MP:0005382
MousePheno	abnormal craniofacial morphology	ADAMTS17 CNBP HSPG2 CCN2 FBN1 MMP2 WNT1 SPRY4 SORL1	2.25e-03	1372	31	9	MP:0000428
MousePheno	brachydactyly	ADAMTS17 SPRY4	2.41e-03	33	31	2	MP:0002544
MousePheno	decreased cranium height	ADAMTS17 HSPG2	2.41e-03	33	31	2	MP:0008525
Domain	TSP_1	ADAMTS17 THSD4 CCN6 CCN2 THSD7B HMCN1 ADAMTS7 ADAMTS9	1.79e-13	63	34	8	PF00090
Domain	TSP1	ADAMTS17 THSD4 CCN6 CCN2 THSD7B HMCN1 ADAMTS7 ADAMTS9	2.33e-13	65	34	8	SM00209
Domain	TSP1_rpt	ADAMTS17 THSD4 CCN6 CCN2 THSD7B HMCN1 ADAMTS7 ADAMTS9	2.33e-13	65	34	8	IPR000884
Domain	TSP1	ADAMTS17 THSD4 CCN6 CCN2 THSD7B HMCN1 ADAMTS7 ADAMTS9	2.33e-13	65	34	8	PS50092
Domain	ADAM_spacer1	ADAMTS17 THSD4 ADAMTS7 ADAMTS9	7.91e-08	23	34	4	IPR010294
Domain	ADAM_spacer1	ADAMTS17 THSD4 ADAMTS7 ADAMTS9	7.91e-08	23	34	4	PF05986
Domain	Growth_fac_rcpt_	CCN6 HSPG2 CCN2 FBN1 EGF HMCN1	3.42e-07	156	34	6	IPR009030
Domain	CYSTEINE_SWITCH	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	8.84e-07	41	34	4	PS00546
Domain	Pept_M10_metallopeptidase	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	1.07e-06	43	34	4	IPR001818
Domain	Wnt	WNT1 WNT2 WNT10B	5.24e-06	19	34	3	IPR005817
Domain	PLAC	ADAMTS17 THSD4 ADAMTS7	5.24e-06	19	34	3	IPR010909
Domain	PLAC	ADAMTS17 THSD4 ADAMTS7	5.24e-06	19	34	3	PS50900
Domain	WNT1	WNT1 WNT2 WNT10B	5.24e-06	19	34	3	SM00097
Domain	Wnt_CS	WNT1 WNT2 WNT10B	5.24e-06	19	34	3	IPR018161
Domain	wnt	WNT1 WNT2 WNT10B	5.24e-06	19	34	3	PF00110
Domain	WNT1	WNT1 WNT2 WNT10B	5.24e-06	19	34	3	PS00246
Domain	Peptidase_M12B_ADAM-TS	ADAMTS17 ADAMTS7 ADAMTS9	1.09e-05	24	34	3	IPR013273
Domain	MetalloPept_cat_dom	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	1.38e-05	81	34	4	IPR024079
Domain	-	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	1.38e-05	81	34	4	3.40.390.10
Domain	ZINC_PROTEASE	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	2.93e-05	98	34	4	PS00142
Domain	IGFBP_CNN	CCN6 CCN2	3.21e-05	5	34	2	IPR012395
Domain	Peptidase_M12B_N	ADAMTS17 ADAMTS7 ADAMTS9	4.82e-05	39	34	3	IPR002870
Domain	Pep_M12B_propep	ADAMTS17 ADAMTS7 ADAMTS9	4.82e-05	39	34	3	PF01562
Domain	DISINTEGRIN_1	ADAMTS17 ADAMTS7 ADAMTS9	5.20e-05	40	34	3	PS00427
Domain	ADAM_MEPRO	ADAMTS17 ADAMTS7 ADAMTS9	5.20e-05	40	34	3	PS50215
Domain	DISINTEGRIN_2	ADAMTS17 ADAMTS7 ADAMTS9	5.20e-05	40	34	3	PS50214
Domain	Reprolysin	ADAMTS17 ADAMTS7 ADAMTS9	5.20e-05	40	34	3	PF01421
Domain	Peptidase_M12B	ADAMTS17 ADAMTS7 ADAMTS9	5.20e-05	40	34	3	IPR001590
Domain	Disintegrin_dom	ADAMTS17 ADAMTS7 ADAMTS9	5.60e-05	41	34	3	IPR001762
Domain	EGF_3	HSPG2 FBN1 EGF HMCN1 SORL1	6.24e-05	235	34	5	PS50026
Domain	EGF	HSPG2 FBN1 EGF HMCN1 SORL1	6.24e-05	235	34	5	SM00181
Domain	SPR	SPRY3 SPRY4	6.72e-05	7	34	2	PS51227
Domain	Sprouty	SPRY3 SPRY4	6.72e-05	7	34	2	IPR007875
Domain	Sprouty	SPRY3 SPRY4	6.72e-05	7	34	2	PF05210
Domain	EGF_CA	HSPG2 FBN1 EGF HMCN1	6.91e-05	122	34	4	SM00179
Domain	EGF-like_Ca-bd_dom	HSPG2 FBN1 EGF HMCN1	7.36e-05	124	34	4	IPR001881
Domain	EGF-like_dom	HSPG2 FBN1 EGF HMCN1 SORL1	8.21e-05	249	34	5	IPR000742
Domain	EGF-like_CS	HSPG2 FBN1 EGF HMCN1 SORL1	1.02e-04	261	34	5	IPR013032
Domain	EGF_2	HSPG2 FBN1 EGF HMCN1 SORL1	1.10e-04	265	34	5	PS01186
Domain	Insulin_GF-bd_Cys-rich_CS	CCN6 CCN2	1.75e-04	11	34	2	IPR017891
Domain	-	EGF HMCN1	1.75e-04	11	34	2	2.40.155.10
Domain	GFP-like	EGF HMCN1	1.75e-04	11	34	2	IPR023413
Domain	IGFBP_N_1	CCN6 CCN2	2.10e-04	12	34	2	PS00222
Domain	Ldl_recept_b	EGF SORL1	2.89e-04	14	34	2	PF00058
Domain	LDLRB	EGF SORL1	2.89e-04	14	34	2	PS51120
Domain	PLAC	ADAMTS17 THSD4	2.89e-04	14	34	2	PF08686
Domain	Glyco_hormone_CN	CCN6 CCN2	3.33e-04	15	34	2	IPR006208
Domain	Cys_knot	CCN6 CCN2	3.33e-04	15	34	2	PF00007
Domain	LY	EGF SORL1	3.33e-04	15	34	2	SM00135
Domain	LDLR_classB_rpt	EGF SORL1	3.33e-04	15	34	2	IPR000033
Domain	CTCK_1	CCN6 CCN2	4.83e-04	18	34	2	PS01185
Domain	IB	CCN6 CCN2	4.83e-04	18	34	2	SM00121
Domain	EGF_CA	FBN1 EGF HMCN1	5.09e-04	86	34	3	PF07645
Domain	IGFBP_N_2	CCN6 CCN2	5.99e-04	20	34	2	PS51323
Domain	IGFBP-like	CCN6 CCN2	5.99e-04	20	34	2	IPR000867
Domain	IGFBP	CCN6 CCN2	5.99e-04	20	34	2	PF00219
Domain	EGF_Ca-bd_CS	FBN1 EGF HMCN1	7.23e-04	97	34	3	IPR018097
Domain	CT	CCN6 CCN2	7.26e-04	22	34	2	SM00041
Domain	EGF_CA	FBN1 EGF HMCN1	7.67e-04	99	34	3	PS01187
Domain	ASX_HYDROXYL	FBN1 EGF HMCN1	7.90e-04	100	34	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBN1 EGF HMCN1	9.36e-04	106	34	3	IPR000152
Domain	Cys_knot_C	CCN6 CCN2	9.40e-04	25	34	2	IPR006207
Domain	CTCK_2	CCN6 CCN2	9.40e-04	25	34	2	PS01225
Domain	cEGF	FBN1 HMCN1	1.02e-03	26	34	2	IPR026823
Domain	cEGF	FBN1 HMCN1	1.02e-03	26	34	2	PF12662
Domain	EGF_1	HSPG2 FBN1 EGF HMCN1	1.14e-03	255	34	4	PS00022
Domain	EGF	HSPG2 EGF HMCN1	1.54e-03	126	34	3	PF00008
Domain	-	EGF SORL1	2.29e-03	39	34	2	2.120.10.30
Domain	LDLR_class-A_CS	HSPG2 SORL1	2.40e-03	40	34	2	IPR023415
Domain	Ldl_recept_a	HSPG2 SORL1	3.03e-03	45	34	2	PF00057
Domain	-	HSPG2 SORL1	3.17e-03	46	34	2	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	EGF SORL1	3.17e-03	46	34	2	IPR011042
Domain	LDLRA_1	HSPG2 SORL1	3.44e-03	48	34	2	PS01209
Domain	LDrepeatLR_classA_rpt	HSPG2 SORL1	3.59e-03	49	34	2	IPR002172
Domain	LDLa	HSPG2 SORL1	3.59e-03	49	34	2	SM00192
Domain	LDLRA_2	HSPG2 SORL1	3.59e-03	49	34	2	PS50068
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS17 THSD4 THSD7B ADAMTS7 ADAMTS9	9.59e-09	39	27	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS17 THSD4 THSD7B ADAMTS7 ADAMTS9	9.59e-09	39	27	5	MM15165
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS17 THSD4 ST3GAL2 THSD7B ADAMTS7 ADAMTS9	4.82e-08	109	27	6	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS17 THSD4 ST3GAL2 THSD7B ADAMTS7 ADAMTS9	5.38e-08	111	27	6	M27416
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS17 THSD4 THSD7B ADAMTS7 ADAMTS9	1.67e-07	68	27	5	M27303
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS17 THSD4 HSPG2 THSD7B ADAMTS7 ADAMTS9	2.44e-07	143	27	6	M27275
Pathway	BIOCARTA_SPRY_PATHWAY	SPRY3 EGF SPRY4	4.19e-06	17	27	3	M1389
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION	WNT1 WNT2 WNT10B	5.95e-06	19	27	3	M47836
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS17 THSD4 HSPG2 THSD7B ADAMTS7 ADAMTS9	6.34e-06	250	27	6	M27554
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT1 WNT2 WNT10B	1.40e-05	25	27	3	MM14940
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT1 WNT2 WNT10B	1.58e-05	26	27	3	M27239
Pathway	WP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY	EGF WNT1 WNT2 WNT10B	1.94e-05	85	27	4	M48315
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR	WNT1 WNT2 WNT10B	1.99e-05	28	27	3	M47835
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT1 WNT2 WNT10B	2.21e-05	29	27	3	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT1 WNT2 WNT10B	2.21e-05	29	27	3	M47377
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	WNT1 WNT2 WNT10B	4.29e-05	36	27	3	M39699
Pathway	KEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT1 WNT2 WNT10B	4.66e-05	37	27	3	M47411
Pathway	WP_ESC_PLURIPOTENCY_PATHWAYS	EGF WNT1 WNT2 WNT10B	6.60e-05	116	27	4	MM15863
Pathway	WP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS	EGF WNT1 WNT2 WNT10B	6.82e-05	117	27	4	M39530
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	WNT1 WNT2 WNT10B	7.88e-05	44	27	3	MM15878
Pathway	KEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT1 WNT2 WNT10B	8.43e-05	45	27	3	M47412
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY	WNT1 WNT2 WNT10B	9.00e-05	46	27	3	M47409
Pathway	WP_PLURIPOTENT_STEM_CELL_DIFFERENTIATION_PATHWAY	EGF WNT1 WNT2	1.02e-04	48	27	3	M39427
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	HSPG2 FBN1 MMP2 ADAMTS9	1.37e-04	140	27	4	M587
Pathway	WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER	CCN2 MMP2 EGF	1.46e-04	54	27	3	M42568
Pathway	WP_PLEURAL_MESOTHELIOMA	CCN2 MMP2 EGF WNT1 WNT2 WNT10B	1.50e-04	439	27	6	M42563
Pathway	KEGG_BASAL_CELL_CARCINOMA	WNT1 WNT2 WNT10B	1.54e-04	55	27	3	M17807
Pathway	KEGG_HEDGEHOG_SIGNALING_PATHWAY	WNT1 WNT2 WNT10B	1.62e-04	56	27	3	M1053
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS	FBN1 EGF WNT1	1.90e-04	59	27	3	M39886
Pathway	WP_BREAST_CANCER_PATHWAY	EGF WNT1 WNT2 WNT10B	1.98e-04	154	27	4	M39739
Pathway	WP_WNT_SIGNALING	WNT1 WNT2 WNT10B	2.09e-04	61	27	3	MM15893
Pathway	WP_LUNG_FIBROSIS	CCN2 MMP2 EGF	2.30e-04	63	27	3	M39477
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	ITGA10 HSPG2 FBN1 MMP2 ADAMTS9	2.32e-04	300	27	5	M610
Pathway	WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER	MMP2 WNT1 WNT2 WNT10B	2.34e-04	161	27	4	M39770
Pathway	KEGG_PATHWAYS_IN_CANCER	MMP2 EGF WNT1 WNT2 WNT10B	3.36e-04	325	27	5	M12868
Pathway	WP_LUNG_FIBROSIS	CCN2 MMP2 EGF	3.56e-04	73	27	3	MM15827
Pathway	BIOCARTA_SPRY_PATHWAY	EGF SPRY4	4.17e-04	16	27	2	MM1500
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	ITGA10 HSPG2 FBN1	5.57e-04	85	27	3	M16441
Pathway	REACTOME_ATTACHMENT_AND_ENTRY	HAVCR1 HSPG2	5.92e-04	19	27	2	M41729
Pathway	WP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA	WNT1 WNT2 WNT10B	6.38e-04	89	27	3	M39563
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	WNT1 WNT2 WNT10B	7.48e-04	94	27	3	M797
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	ADAMTS17 THSD4 ST3GAL2 FBN1 THSD7B DCTN4 UHRF2 ADAMTS7 ADAMTS9	7.72e-04	1389	27	9	MM15307
Pathway	WP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER	WNT1 WNT2 WNT10B	8.44e-04	98	27	3	M39731
Pathway	KEGG_MELANOGENESIS	WNT1 WNT2 WNT10B	9.21e-04	101	27	3	M7761
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	WNT1 WNT2 WNT10B	9.21e-04	101	27	3	MM15829
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	WNT1 WNT2 WNT10B	9.21e-04	101	27	3	M39387
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	CCN2 FBN1	1.03e-03	25	27	2	M39713
Pathway	WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT	WNT1 WNT2 WNT10B	1.18e-03	110	27	3	M39492
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	ADAMTS17 THSD4 ST3GAL2 FBN1 THSD7B DCTN4 UHRF2 ADAMTS7 ADAMTS9	1.19e-03	1475	27	9	M19806
Pathway	WP_WNT_SIGNALING_WP428	WNT1 WNT2 WNT10B	1.27e-03	113	27	3	M39669
Pathway	WP_BURN_WOUND_HEALING	FBN1 MMP2 EGF	1.27e-03	113	27	3	M42571
Pathway	PID_WNT_SIGNALING_PATHWAY	WNT1 WNT2	1.29e-03	28	27	2	M77
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	WNT1 WNT2 WNT10B	1.44e-03	118	27	3	M39852
Pathway	REACTOME_EARLY_SARS_COV_2_INFECTION_EVENTS	HAVCR1 HSPG2	2.26e-03	37	27	2	M45028
Pathway	REACTOME_SARS_COV_2_INFECTION	CNBP HAVCR1 HSPG2 ST3GAL2	2.37e-03	299	27	4	M41727
Pathway	WP_CANCER_PATHWAYS	MMP2 EGF WNT1 WNT2 WNT10B	2.47e-03	507	27	5	M48302
Pathway	WP_BLADDER_CANCER	MMP2 EGF	2.63e-03	40	27	2	M39523
Pathway	PID_AMB2_NEUTROPHILS_PATHWAY	CCN2 MMP2	2.77e-03	41	27	2	M159
Pathway	KEGG_BLADDER_CANCER	MMP2 EGF	2.90e-03	42	27	2	M19096
Pathway	KEGG_WNT_SIGNALING_PATHWAY	WNT1 WNT2 WNT10B	2.92e-03	151	27	3	M19428
Pathway	WP_TGFBETA_SIGNALING_PATHWAY	EGF WNT1	4.58e-03	53	27	2	MM15880
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING	EGF WNT1	4.93e-03	55	27	2	M39351
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS17 THSD4 CCN6 CCN2 MMP2 THSD7B HMCN1 ADAMTS7 ADAMTS9	4.14e-17	75	35	9	20637190
Pubmed	Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.	FBN1 WNT1 WNT2 WNT10B	5.08e-09	21	35	4	17943183
Pubmed	Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".	CCN2 MMP2 EGF WNT2 WNT10B GPX4	1.93e-08	172	35	6	20628624
Pubmed	Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.	CCN6 WNT1 WNT2 WNT10B	4.40e-08	35	35	4	19185060
Pubmed	Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms.	SPRY3 EGF SPRY4	7.81e-08	9	35	3	16339969
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS17 ADAMTS7 ADAMTS9	2.04e-07	12	35	3	25770910
Pubmed	Expression patterns of Wnt genes in mouse gut development.	WNT1 WNT2 WNT10B	4.21e-07	15	35	3	11429295
Pubmed	Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation.	WNT1 WNT2 WNT10B	4.21e-07	15	35	3	15044261
Pubmed	The Wnts.	WNT1 WNT2 WNT10B	5.18e-07	16	35	3	9889131
Pubmed	A threshold requirement for Gbx2 levels in hindbrain development.	SPRY3 WNT1 SPRY4	6.29e-07	17	35	3	16651541
Pubmed	Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.	WNT1 WNT2 WNT10B	8.95e-07	19	35	3	11520664
Pubmed	MMP-2 regulates Erk1/2 phosphorylation and aortic dilatation in Marfan syndrome.	FBN1 MMP2	9.84e-07	2	35	2	22550139
Pubmed	Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc.	HSPG2 FBN1	9.84e-07	2	35	2	23104139
Pubmed	Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts.	WNT1 WNT2	9.84e-07	2	35	2	9652750
Pubmed	CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes.	HSPG2 CCN2	9.84e-07	2	35	2	12811819
Pubmed	Interleukin 12p40 Deficiency Promotes Abdominal Aortic Aneurysm by Activating CCN2/MMP2 Pathways.	CCN2 MMP2	9.84e-07	2	35	2	33470127
Pubmed	ADAMTSL6β protein rescues fibrillin-1 microfibril disorder in a Marfan syndrome mouse model through the promotion of fibrillin-1 assembly.	THSD4 FBN1	9.84e-07	2	35	2	21880733
Pubmed	The Fbn1 gene variant governs passive ascending aortic mechanics in the mgΔlpn mouse model of Marfan syndrome when superimposed to perlecan haploinsufficiency.	HSPG2 FBN1	9.84e-07	2	35	2	38545339
Pubmed	A novel ADAMTS17 variant that causes Weill-Marchesani syndrome 4 alters fibrillin-1 and collagen type I deposition in the extracellular matrix.	ADAMTS17 FBN1	9.84e-07	2	35	2	31726086
Pubmed	Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells.	CCN2 WNT1	9.84e-07	2	35	2	15496414
Pubmed	Long noncoding RNA ADAMTS9-AS1 represses ferroptosis of endometrial stromal cells by regulating the miR-6516-5p/GPX4 axis in endometriosis.	ADAMTS9 GPX4	9.84e-07	2	35	2	35173188
Pubmed	Is HSPG2 a modifier gene for Marfan syndrome?	HSPG2 FBN1	9.84e-07	2	35	2	32514132
Pubmed	ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation.	THSD4 FBN1	9.84e-07	2	35	2	19940141
Pubmed	Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and Migration of Glioblastoma-Derived Cells.	SPRY3 SPRY4	9.84e-07	2	35	2	31374860
Pubmed	The Novel miRNA N-72 Regulates EGF-Induced Migration of Human Amnion Mesenchymal Stem Cells by Targeting MMP2.	MMP2 EGF	9.84e-07	2	35	2	29734654
Pubmed	Microfibrils at basement membrane zones interact with perlecan via fibrillin-1.	HSPG2 FBN1	9.84e-07	2	35	2	15657057
Pubmed	Epithelial Wnt10a Is Essential for Tooth Root Furcation Morphogenesis.	WNT1 WNT2 WNT10B	1.23e-06	21	35	3	31914354
Pubmed	Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.	HSPG2 CCN2 MMP2 EGF	1.35e-06	81	35	4	39217171
Pubmed	Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina.	WNT1 WNT2 WNT10B	1.42e-06	22	35	3	12815618
Pubmed	Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.	WNT1 WNT2 WNT10B	1.63e-06	23	35	3	27362799
Pubmed	GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.	FBN1 MMP2 ADAMTS9	1.63e-06	23	35	3	29567669
Pubmed	Comprehensive proteomic characterization of stem cell-derived extracellular matrices.	HSPG2 CCN2 FBN1 MMP2	1.72e-06	86	35	4	28327460
Pubmed	Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development.	HSPG2 CCN2 WNT2 WNT10B	2.06e-06	90	35	4	30228991
Pubmed	Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to connective tissue growth factor/CCN2 because of an increase in the levels of endogenous fibronectin.	CCN2 MMP2	2.95e-06	3	35	2	19276073
Pubmed	p53 Mediates epidermal growth factor (EGF) induction of MMP-2 transcription and trophoblast invasion.	MMP2 EGF	2.95e-06	3	35	2	19853299
Pubmed	Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome.	FBN1 MMP2	2.95e-06	3	35	2	17641224
Pubmed	Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene.	CCN2 MMP2	2.95e-06	3	35	2	23048035
Pubmed	Extracellular modulation of the Hedgehog, Wnt and TGF-beta signalling pathways during embryonic development.	WNT1 WNT2	2.95e-06	3	35	2	10449357
Pubmed	Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.	WNT1 WNT2 WNT10B	3.01e-06	28	35	3	20940229
Pubmed	Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development.	WNT1 WNT2 WNT10B	3.01e-06	28	35	3	24394376
Pubmed	Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.	WNT1 WNT2 WNT10B	3.35e-06	29	35	3	22956684
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	WNT1 WNT2 WNT10B	3.35e-06	29	35	3	18364260
Pubmed	Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.	WNT1 WNT2 WNT10B	3.72e-06	30	35	3	19282366
Pubmed	Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract.	WNT1 WNT2 WNT10B	3.72e-06	30	35	3	21936019
Pubmed	Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development.	WNT1 WNT2 WNT10B	3.72e-06	30	35	3	15880404
Pubmed	Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.	WNT1 WNT2 WNT10B	3.72e-06	30	35	3	36305473
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	HSPG2 CCN2 FBN1 MMP2 ADAMTS7	4.83e-06	248	35	5	24006456
Pubmed	Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis.	CCN2 MMP2	5.90e-06	4	35	2	17908800
Pubmed	Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis.	WNT1 WNT2	5.90e-06	4	35	2	10640709
Pubmed	Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.	WNT1 WNT2	5.90e-06	4	35	2	10347172
Pubmed	Weill-Marchesani Syndrome	ADAMTS17 FBN1	5.90e-06	4	35	2	20301293
Pubmed	Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and β-catenin Expression in Operable Non-small Cell Lung Cancer.	WNT1 WNT2	5.90e-06	4	35	2	34666560
Pubmed	Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells.	SPRY3 SPRY4	5.90e-06	4	35	2	11238463
Pubmed	Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses.	SPRY3 SPRY4	5.90e-06	4	35	2	23074222
Pubmed	Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation.	CCN2 EGF	5.90e-06	4	35	2	15003992
Pubmed	Regulation of osteoblastogenesis and bone mass by Wnt10b.	WNT1 WNT10B	5.90e-06	4	35	2	15728361
Pubmed	WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells.	WNT1 WNT10B	5.90e-06	4	35	2	11350055
Pubmed	A uropathogenic E. coli UTI89 model of prostatic inflammation and collagen accumulation for use in studying aberrant collagen production in the prostate.	CCN2 WNT10B	5.90e-06	4	35	2	33135480
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	WNT1 WNT2 WNT10B	5.98e-06	35	35	3	30940800
Pubmed	O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.	ADAMTS17 CCN2 FBN1	6.52e-06	36	35	3	35167946
Pubmed	Integrated analysis of Wnt signalling system component gene expression.	WNT1 WNT2 WNT10B	7.09e-06	37	35	3	35831952
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	FBN1 MMP2 WNT2	7.09e-06	37	35	3	34323105
Pubmed	Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.	WNT1 WNT2 WNT10B	7.09e-06	37	35	3	15342465
Pubmed	Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.	WNT1 WNT2 WNT10B	7.09e-06	37	35	3	18800919
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	HSPG2 MMP2 ADAMTS9	7.69e-06	38	35	3	29743679
Pubmed	Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.	WNT1 WNT2 WNT10B	7.69e-06	38	35	3	21041481
Pubmed	Tissue-specific requirements of beta-catenin in external genitalia development.	WNT1 WNT2 WNT10B	7.69e-06	38	35	3	18635608
Pubmed	Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis.	WNT1 WNT2 WNT10B	7.69e-06	38	35	3	23190887
Pubmed	Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.	HSPG2 MMP2 ADAMTS9	7.69e-06	38	35	3	18267097
Pubmed	Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors.	WNT1 WNT2 WNT10B	8.32e-06	39	35	3	24586192
Pubmed	The modular architecture of a new family of growth regulators related to connective tissue growth factor.	CCN6 CCN2	9.82e-06	5	35	2	7687569
Pubmed	Heparanase localization during palatogenesis in mice.	HSPG2 MMP2	9.82e-06	5	35	2	23509775
Pubmed	A functional interaction between sprouty proteins and caveolin-1.	SPRY3 SPRY4	9.82e-06	5	35	2	16877379
Pubmed	Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition.	WNT2 WNT10B	9.82e-06	5	35	2	22041457
Pubmed	Expression of Wnts in the developing murine secondary palate.	WNT2 WNT10B	9.82e-06	5	35	2	19598129
Pubmed	Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.	SPRY3 SPRY4	9.82e-06	5	35	2	10498682
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	HSPG2 FBN1	9.82e-06	5	35	2	23493297
Pubmed	Gpr177 regulates pulmonary vasculature development.	WNT1 WNT2 WNT10B	1.20e-05	44	35	3	23884445
Pubmed	Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.	WNT1 WNT2 WNT10B	1.47e-05	47	35	3	16678101
Pubmed	Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.	WNT1 WNT2 WNT10B	1.47e-05	47	35	3	28813421
Pubmed	Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.	WNT1 WNT2 WNT10B	1.47e-05	47	35	3	18351675
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	WNT1 WNT2 WNT10B	1.47e-05	47	35	3	33141892
Pubmed	Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).	CCN6 CCN2	1.47e-05	6	35	2	26498181
Pubmed	Proteolytic cleavage of versican during cardiac cushion morphogenesis.	MMP2 ADAMTS9	1.47e-05	6	35	2	16691565
Pubmed	Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.	WNT1 WNT10B	1.47e-05	6	35	2	12379851
Pubmed	Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.	WNT1 WNT2	1.47e-05	6	35	2	10557084
Pubmed	Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice.	WNT1 WNT10B	1.47e-05	6	35	2	7892260
Pubmed	Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions.	HSPG2 CCN2	1.47e-05	6	35	2	12036876
Pubmed	Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.	WNT1 WNT2 WNT10B	1.67e-05	49	35	3	19562671
Pubmed	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.	FBN1 MMP2 WNT2	1.99e-05	52	35	3	30389913
Pubmed	Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.	MMP2 ADAMTS9	2.06e-05	7	35	2	23354118
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	ADAMTS17 HSPG2 FBN1 HMCN1	2.39e-05	167	35	4	22159717
Pubmed	Wnt-3a regulates somite and tailbud formation in the mouse embryo.	WNT1 WNT2	2.74e-05	8	35	2	8299937
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	ADAMTS17 FBN1	2.74e-05	8	35	2	31201465
Pubmed	Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.	HSPG2 MMP2	2.74e-05	8	35	2	31600777
Pubmed	Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth.	WNT1 WNT10B	2.74e-05	8	35	2	9769173
Pubmed	Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors.	CCN2 MMP2	2.74e-05	8	35	2	15255181
Pubmed	Inhibition of adipogenesis by Wnt signaling.	WNT1 WNT10B	2.74e-05	8	35	2	10937998
Pubmed	Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.	WNT1 WNT2	2.74e-05	8	35	2	2279700
Pubmed	SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.	THSD4 HSPG2 FBN1 MMP2	2.74e-05	173	35	4	23979707
Interaction	CCN6 interactions	CCN6 ADAMTS7 SORL1	3.46e-06	19	32	3	int:CCN6
Interaction	PI15 interactions	THSD4 HSPG2 ADAMTS7 SORL1	8.81e-06	83	32	4	int:PI15
Interaction	EDN3 interactions	THSD4 HSPG2 ADAMTS7 SORL1	2.50e-05	108	32	4	int:EDN3
Interaction	BCAN interactions	THSD4 MMP2 ADAMTS7	2.51e-05	36	32	3	int:BCAN
Interaction	FBXO2 interactions	THSD4 HSPG2 FBN1 ADAMTS7 WNT10B SORL1	4.01e-05	411	32	6	int:FBXO2
Interaction	SORL1 interactions	CCN6 SP110 WNT2 SORL1	6.52e-05	138	32	4	int:SORL1
Interaction	FZD9 interactions	WNT1 WNT2	6.80e-05	8	32	2	int:FZD9
Cytoband	15q23	THSD4 HEXA-AS1	5.54e-04	44	36	2	15q23
Cytoband	Ensembl 112 genes in cytogenetic band chr15q23	THSD4 HEXA-AS1	1.32e-03	68	36	2	chr15q23
Cytoband	12q13	WNT1 WNT10B	1.44e-03	71	36	2	12q13
Cytoband	Ensembl 112 genes in cytogenetic band chr5q33	HAVCR1 DCTN4	3.90e-03	118	36	2	chr5q33
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS17 ADAMTS7 ADAMTS9	2.83e-06	19	27	3	50
GeneFamily	Wnt family\|Endogenous ligands	WNT1 WNT2 WNT10B	2.83e-06	19	27	3	360
GeneFamily	CYR61/CTGF/NOV matricellular proteins	CCN6 CCN2	3.21e-05	6	27	2	1046
GeneFamily	PHD finger proteins	UHRF2 SP110	7.93e-03	90	27	2	88
Coexpression	NABA_MATRISOME	ADAMTS17 THSD4 CCN6 HSPG2 CCN2 FBN1 MMP2 EGF HMCN1 ADAMTS7 ADAMTS9 WNT1 WNT2 WNT10B	2.44e-11	1008	36	14	MM17056
Coexpression	NABA_MATRISOME	ADAMTS17 THSD4 CCN6 HSPG2 CCN2 FBN1 MMP2 EGF HMCN1 ADAMTS7 ADAMTS9 WNT1 WNT2 WNT10B	3.08e-11	1026	36	14	M5889
Coexpression	HAY_BONE_MARROW_STROMAL	THSD4 CCN6 HSPG2 CCN2 FBN1 MMP2 THSD7B ADAMTS9 SPRY4	6.96e-07	767	36	9	M39209
Coexpression	NABA_CORE_MATRISOME	THSD4 CCN6 HSPG2 CCN2 FBN1 HMCN1	1.70e-06	270	36	6	MM17057
Coexpression	NABA_CORE_MATRISOME	THSD4 CCN6 HSPG2 CCN2 FBN1 HMCN1	1.89e-06	275	36	6	M5884
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS17 MMP2 EGF ADAMTS7 ADAMTS9 WNT1 WNT2 WNT10B	5.72e-06	738	36	8	MM17058
Coexpression	NABA_ECM_GLYCOPROTEINS	THSD4 CCN6 CCN2 FBN1 HMCN1	6.12e-06	191	36	5	MM17059
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS17 MMP2 EGF ADAMTS7 ADAMTS9 WNT1 WNT2 WNT10B	6.50e-06	751	36	8	M5885
Coexpression	NABA_ECM_GLYCOPROTEINS	THSD4 CCN6 CCN2 FBN1 HMCN1	6.94e-06	196	36	5	M3008
Coexpression	TRAVAGLINI_LUNG_ALVEOLAR_FIBROBLAST_CELL	CCN2 MMP2 HMCN1 WNT2	7.44e-05	164	36	4	M41676
Coexpression	AGARWAL_AKT_PATHWAY_TARGETS	MMP2 EGF	1.00e-04	11	36	2	M3495
Coexpression	GRUETZMANN_PANCREATIC_CANCER_UP	FBN1 MMP2 WNT2 SORL1 GPX4	1.25e-04	359	36	5	M15193
Coexpression	GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_UP	HEXA-AS1 MMP2 SP110 SORL1	1.57e-04	199	36	4	M8580
Coexpression	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	APLP1 CCN2 FBN1 MMP2	1.60e-04	200	36	4	M5930
Coexpression	GSE24210_TCONV_VS_TREG_UP	HAVCR1 EGF SORL1 GPX4	1.60e-04	200	36	4	M7851
Coexpression	MAHADEVAN_GIST_MORPHOLOGICAL_SWITCH	CCN2 MMP2	1.90e-04	15	36	2	M6900
Coexpression	JI_CARCINOGENESIS_BY_KRAS_AND_STK11_DN	MMP2 WNT2	2.46e-04	17	36	2	M1767
Coexpression	JI_CARCINOGENESIS_BY_KRAS_AND_STK11_DN	MMP2 WNT2	2.46e-04	17	36	2	MM1225
Coexpression	JONES_OVARY_NK_CELL	HSPG2 CCN2 FBN1	2.49e-04	89	36	3	M48353
Coexpression	KONDO_EZH2_TARGETS	CCN2 UHRF2 SPRY4 SORL1	2.68e-04	229	36	4	M5301
Coexpression	NABA_ECM_REGULATORS	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	3.11e-04	238	36	4	M3468
Coexpression	NABA_ECM_REGULATORS	ADAMTS17 MMP2 ADAMTS7 ADAMTS9	3.31e-04	242	36	4	MM17062
Coexpression	ZIRN_TRETINOIN_RESPONSE_UP	THSD4 CCN2	3.43e-04	20	36	2	M581
Coexpression	ONDER_CDH1_TARGETS_2_UP	ITGA10 CCN2 FBN1 MMP2	4.16e-04	257	36	4	M13867
Coexpression	VERNELL_RETINOBLASTOMA_PATHWAY_DN	CCN2 DCTN4	4.56e-04	23	36	2	M12456
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#4_top-relative-expression-ranked_200	FBN1 MMP2 HMCN1	4.13e-05	42	34	3	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k4_200
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#3_top-relative-expression-ranked_500	FBN1 MMP2 THSD7B HMCN1	4.21e-05	122	34	4	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k3_500
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_200	FBN1 MMP2 HMCN1 ADAMTS9	6.81e-05	138	34	4	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_200
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#2_top-relative-expression-ranked_200	FBN1 MMP2 HMCN1	1.15e-04	59	34	3	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k2_200
CoexpressionAtlas	Mesoderm Day 15-reprogram_NA_vs_Mesoderm Day 15-reprogram_OSK-L-l-p53KD-Confounder_removed-fold2.0_adjp0.05	HAVCR1 HSPG2 CCN2 ADAMTS7	1.86e-04	179	34	4	PCBC_ratio_MESO-15_from-ESC_vs_MESO-15_from-OSK-L-l-p53KD_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 15-method_NA_vs_Mesoderm Day 15-method_episomal-Confounder_removed-fold2.0_adjp0.05	HAVCR1 HSPG2 CCN2 ADAMTS7	1.86e-04	179	34	4	PCBC_ratio_MESO-15_from-ESC_vs_MESO-15_from-episomal_cfr-2X-p05
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_500	ADAMTS17 FBN1 MMP2 THSD7B HMCN1	2.43e-04	357	34	5	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_500
CoexpressionAtlas	kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_StemCellamp_k-means-cluster#1_top-relative-expression-ranked_500	ADAMTS17 OR10H5 HMCN1 ADAMTS9	2.48e-04	193	34	4	gudmap_kidney single cell_adult_JuxtaGlomCell_Ren1Gfp_Scamp_k1_500
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_2500_k-means-cluster#3	HAVCR1 APLP1 FBN1 HMCN1 ADAMTS9 WNT1 WNT2 WNT10B	2.65e-04	1094	34	8	ratio_EB_vs_SC_2500_K3
CoexpressionAtlas	dev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#3_top-relative-expression-ranked_200	FBN1 MMP2 HMCN1	3.05e-04	82	34	3	gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k3_200
ToppCell	metastatic_Lymph_Node-Fibroblasts-Myofibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	HSPG2 CCN2 FBN1 MMP2 HMCN1 WNT2	9.48e-09	191	36	6	aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-sinusoidal_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TSPAN6 HSPG2 THSD7B HMCN1 ADAMTS9 SPRY4	1.07e-08	195	36	6	22a481927147ec4ae9d59e6af7c87df0e9cb51e4
ToppCell	droplet-Trachea\|droplet / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 ITGA10 HSPG2 CCN2 FBN1 MMP2	1.21e-08	199	36	6	1c7d30765ddb2291967da5d15664c6238c680c1d
ToppCell	droplet-Trachea\|droplet / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD4 ITGA10 HSPG2 CCN2 FBN1 MMP2	1.21e-08	199	36	6	b9038a1ccf3ef3123e2e39afbe6213c363437443
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL14A1+_matrix_FBs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	HSPG2 FBN1 MMP2 WNT2 WNT10B	3.79e-07	185	36	5	506eee2c1b6e8acec3aa8b2c66868010006c4c14
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCN2 FBN1 MMP2 HMCN1 WNT2	3.89e-07	186	36	5	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ADAMTS17 FBN1 MMP2 HMCN1 WNT2	4.21e-07	189	36	5	dc5164591dea45b420798b94dda211be03daa70c
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ADAMTS17 FBN1 MMP2 HMCN1 WNT2	4.32e-07	190	36	5	1196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	HSPG2 FBN1 MMP2 HMCN1 ADAMTS7	4.67e-07	193	36	5	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS17 HSPG2 CCN2 FBN1 MMP2	4.67e-07	193	36	5	9d0b966d13cbce97beb43de6dc77f006c363a181
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	HSPG2 FBN1 MMP2 HMCN1 ADAMTS7	4.67e-07	193	36	5	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCell	10x5'v1-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HSPG2 THSD7B HMCN1 ADAMTS9 SPRY4	4.79e-07	194	36	5	953578102ffc7b612ee8fce45e414750800fef5d
ToppCell	10x5'v1-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HSPG2 THSD7B HMCN1 ADAMTS9 SPRY4	4.79e-07	194	36	5	e141beafc9252e5d8c949252bfab53e127c881dc
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 HSPG2 MMP2 ADAMTS9 WNT2	4.91e-07	195	36	5	841fde528ecb293e07b5e00e499d1e9f0b0dce14
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCN2 FBN1 MMP2 HMCN1 WNT2	4.91e-07	195	36	5	4243190ad291d56694e2155954dbaa879c9d3844
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 HSPG2 FBN1 MMP2 WNT2	4.91e-07	195	36	5	223f5f07dc28fa13a09bb589884c58043c7928c7
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCN2 FBN1 MMP2 HMCN1 WNT2	4.91e-07	195	36	5	df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCN2 FBN1 MMP2 HMCN1 WNT2	5.04e-07	196	36	5	42e9828222a9663525d571633e8a454c30bfa7f8
ToppCell	droplet-Bladder-nan-3m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 HSPG2 FBN1 MMP2 WNT2	5.04e-07	196	36	5	f47e551ba484687ba6ce8c29a085106131364042
ToppCell	IPF-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	CCN2 FBN1 MMP2 HMCN1 WNT2	5.04e-07	196	36	5	7fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCell	metastatic_Lymph_Node-Fibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	HSPG2 FBN1 MMP2 HMCN1 WNT2	5.04e-07	196	36	5	275e153347caf94edc0c50021bbab49c8696fecb
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 ITGA10 CCN2 FBN1 MMP2	5.29e-07	198	36	5	d3a475be01657a03fcbb0ee0a246b1e90deacaa4
ToppCell	droplet-Trachea-3m-Mesenchymal\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD4 ITGA10 CCN2 FBN1 MMP2	5.29e-07	198	36	5	1beed34f469aad07e8f674f0b668d6e1e916403c
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THSD4 ITGA10 CCN6 CCN2 MMP2	5.29e-07	198	36	5	55f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCell	droplet-Trachea-nan-3m-Mesenchymal\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 ITGA10 CCN2 FBN1 MMP2	5.29e-07	198	36	5	985022c1722ab7b67675ebe814022a439e715b5e
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THSD4 ITGA10 CCN6 CCN2 MMP2	5.29e-07	198	36	5	c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CCN2 FBN1 MMP2 HMCN1 WNT2	5.29e-07	198	36	5	f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Myofibroblasts\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CCN2 FBN1 MMP2 HMCN1 WNT2	5.43e-07	199	36	5	7a227c239afdaebcac84644d9b2653a5f1a4be71
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CCN2 FBN1 MMP2 HMCN1 WNT2	5.43e-07	199	36	5	66a79732caf2f04c09b4d9832377aa01ca477677
ToppCell	Biopsy_Other_PF-Mesenchymal-Myofibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	CCN2 FBN1 MMP2 HMCN1 WNT2	5.56e-07	200	36	5	e504570fd7eec1524c401b1cfa9d10822d80d994
ToppCell	cellseq-Mesenchymal-Fibroblastic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CCN2 FBN1 MMP2 HMCN1 WNT2	5.56e-07	200	36	5	8978867bf69c830b1e48cac2ad6b512dbe60f149
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	CCN2 FBN1 MMP2 HMCN1 WNT2	5.56e-07	200	36	5	4f7e26b27bd51c32420ed8c2f52d070aee542159
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Myofibroblasts\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	CCN2 FBN1 MMP2 HMCN1 WNT2	5.56e-07	200	36	5	ca777a7d001848f6d01c613ff2bda7e4f3e20521
ToppCell	21-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	THSD7B HMCN1 ADAMTS9 SPRY4	8.10e-06	159	36	4	4f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCN2 EGF HMCN1 SORL1	8.72e-06	162	36	4	36ddebe3bb172c992739353b7b049b2dde98b559
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 ITGA10 CCN2 MMP2	9.60e-06	166	36	4	37794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 ITGA10 CCN2 MMP2	9.60e-06	166	36	4	81c546c6d847e49e662b81e71992ca0f7a99e890
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN6 ADAMTS17 THSD4 HMCN1	1.01e-05	168	36	4	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	mild_COVID-19-HSPC\|mild_COVID-19 / disease group, cell group and cell class (v2)	TSPAN6 HSPG2 CRYGD FBN1	1.01e-05	168	36	4	90b33962adb77d8326dee403712118398b4d1315
ToppCell	367C-Fibroblasts-Fibroblast-G-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SPRY3 FBN1 MMP2 WNT2	1.01e-05	168	36	4	b8c65542a0701ae31f49d332d87a64578e24b4e3
ToppCell	367C-Fibroblasts-Fibroblast-G\|367C / Donor, Lineage, Cell class and subclass (all cells)	SPRY3 FBN1 MMP2 WNT2	1.01e-05	168	36	4	8c95093b1ea45826f62893edd3c410fe53b563a4
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN6 ADAMTS17 THSD4 HMCN1	1.01e-05	168	36	4	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	mild_COVID-19-HSPC\|World / disease group, cell group and cell class (v2)	TSPAN6 HSPG2 CRYGD FBN1	1.05e-05	170	36	4	85c476e0bc496445e868a88849960598d97bdea2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 HSPG2 CCN2 FBN1	1.08e-05	171	36	4	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 HSPG2 CCN2 FBN1	1.08e-05	171	36	4	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS17 EGF HMCN1 FRMPD1	1.13e-05	173	36	4	4bc6d93716f093b460c8b047199db8cab5fea720
ToppCell	facs-Heart-RA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN6 THSD4 HMCN1 WNT2	1.16e-05	174	36	4	42dfb6f42b72e40e203b3ef341117bccf3553d54
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS17 FBN1 MMP2 WNT2	1.16e-05	174	36	4	3c47d069bd836599a8d40eae485c23d4d3487517
ToppCell	facs-Heart-RA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN6 THSD4 HMCN1 WNT2	1.16e-05	174	36	4	f04edf2ca6788875c9918611e416fb739924382e
ToppCell	severe_COVID-19-HSPC\|severe_COVID-19 / disease group, cell group and cell class (v2)	HSPG2 CRYGD FBN1 MMP2	1.16e-05	174	36	4	6d35bacf073537b272ff821e604c899fb9ce6a7c
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA10 CCN2 FBN1 HMCN1	1.18e-05	175	36	4	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	CCN2 FBN1 MMP2 HMCN1	1.21e-05	176	36	4	510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	CCN2 MMP2 HMCN1 WNT2	1.24e-05	177	36	4	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	severe_COVID-19-HSPC\|World / disease group, cell group and cell class (v2)	HSPG2 CRYGD FBN1 MMP2	1.24e-05	177	36	4	289f6aed6f054b04b01659434d8c8b467d1bf5dd
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	CCN2 MMP2 HMCN1 WNT2	1.24e-05	177	36	4	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	control-Others-CD34+_GATA2+_cells\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	HSPG2 CRYGD FBN1 MMP2	1.26e-05	178	36	4	2120bd3e099b0b271bf079db9827a2f3eee2f909
ToppCell	PBMC-Mild-Hematopoietic-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HSPG2 CRYGD FBN1 MMP2	1.29e-05	179	36	4	2f690f933bf6b99abeb31766e0b22bdbe36c1ba0
ToppCell	COVID-19_Mild-Hematopoietic_SC-HSPC\|COVID-19_Mild / Disease group, lineage and cell class	HSPG2 CRYGD FBN1 MMP2	1.29e-05	179	36	4	19fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HSPG2 CRYGD FBN1 MMP2	1.29e-05	179	36	4	4bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HSPG2 CRYGD FBN1 MMP2	1.29e-05	179	36	4	3e2c937369b8190fd5d5a31689d029e6e89fb5e2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7B EGF HMCN1 FRMPD1	1.29e-05	179	36	4	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	COVID-19_Mild-Hematopoietic_SC\|COVID-19_Mild / Disease group, lineage and cell class	HSPG2 CRYGD FBN1 MMP2	1.29e-05	179	36	4	50a073166e34bcfa52a62c4dafb3aef724e0fa8e
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 MMP2 ADAMTS9 WNT2	1.32e-05	180	36	4	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	HSPG2 CRYGD FBN1 MMP2	1.35e-05	181	36	4	54a19cf6a3b752e2391feb8b316bebee0e602d17
ToppCell	PBMC-Mild-Hematopoietic-HSPC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	HSPG2 CRYGD FBN1 MMP2	1.35e-05	181	36	4	5b84625b1d3737708001b64f6da9360330d39a27
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	CCN2 FBN1 HMCN1 WNT2	1.35e-05	181	36	4	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HSPG2 CRYGD FBN1 MMP2	1.35e-05	181	36	4	e7f7b519c2a01c15f26df11ec9b434c0d1630c7a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS17 EGF HMCN1 FRMPD1	1.35e-05	181	36	4	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	facs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS17 CCN2 FBN1 WNT2	1.38e-05	182	36	4	dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell	Control-Hematopoietic_SC-HSPC\|Control / Disease group, lineage and cell class	HSPG2 CRYGD FBN1 MMP2	1.38e-05	182	36	4	14e347c0e6444410f1948851407bb18c706569f4
ToppCell	Control-Hematopoietic_SC\|Control / Disease group, lineage and cell class	HSPG2 CRYGD FBN1 MMP2	1.38e-05	182	36	4	43243c6bae2ac7fa3fd1f193a17f61ee4d938ea9
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HSPG2 CRYGD FBN1 MMP2	1.38e-05	182	36	4	d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HSPG2 CRYGD FBN1 MMP2	1.38e-05	182	36	4	918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCN2 FBN1 MMP2 HMCN1	1.38e-05	182	36	4	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	facs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS17 CCN2 FBN1 WNT2	1.38e-05	182	36	4	c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HSPG2 CRYGD FBN1 MMP2	1.38e-05	182	36	4	2a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 HSPG2 HMCN1 SPRY4	1.41e-05	183	36	4	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 HSPG2 HMCN1 SPRY4	1.41e-05	183	36	4	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TSPAN6 HSPG2 FBN1 MMP2	1.41e-05	183	36	4	351d575339038bd4a66f408da518c567444208e8
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN2 MMP2 ADAMTS7 SPRY4	1.44e-05	184	36	4	1c857126c0ea0671f0d60b048efca288d348d653
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA10 CCN2 MMP2 HMCN1	1.47e-05	185	36	4	7b1c5d99bd7a6e148524029758cee244a17f5d09
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS17 FBN1 MMP2 WNT2	1.47e-05	185	36	4	46460e74cc613df9043f5404e7342aa13cc34873
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA10 CCN2 MMP2 HMCN1	1.47e-05	185	36	4	e9033a03d574956cf3ae228740b3166e40a6397f
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS17 CCN2 FBN1 MMP2	1.47e-05	185	36	4	355b03c7ea438681e11a2b872c798c9ea26e1486
ToppCell	390C-Fibroblasts-Fibroblast-F\|390C / Donor, Lineage, Cell class and subclass (all cells)	FBN1 MMP2 WNT2 WNT10B	1.47e-05	185	36	4	2c1f14f77faeee2acb388d997c5a27a7fef79be1
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS17 FBN1 MMP2 HMCN1	1.47e-05	185	36	4	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS17 FBN1 MMP2 HMCN1	1.47e-05	185	36	4	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	390C-Fibroblasts-Fibroblast-F-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FBN1 MMP2 WNT2 WNT10B	1.47e-05	185	36	4	37db8e0b1f59274227f6fc2362167eb44bd080ef
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA10 CCN2 MMP2 HMCN1	1.47e-05	185	36	4	578f12c6b2e33d09598dc8e022a20c8555d1325c
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN6 APLP1 CCN2 WNT1	1.47e-05	185	36	4	872720275789d249c9859de825a923803d458875
ToppCell	P03\|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS17 CCN2 FBN1 WNT2	1.47e-05	185	36	4	a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SPRY3 HSPG2 CCN2 HMCN1	1.50e-05	186	36	4	a906020a8df6fcca474b278f746c553b177a56b4
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS17 FBN1 MMP2 HMCN1	1.50e-05	186	36	4	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS17 FBN1 MMP2 WNT2	1.50e-05	186	36	4	88e6246172d816806a498a5c1f38e699f2f5d7c2
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	ITGA10 HSPG2 HMCN1 ADAMTS9	1.53e-05	187	36	4	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Scara5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 CCN2 FBN1 WNT2	1.53e-05	187	36	4	7beba2a5d5978f2ae7d8bde10815705cf2572211
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	ADAMTS17 CCN2 FBN1 HMCN1	1.53e-05	187	36	4	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCN2 FBN1 MMP2 WNT2	1.57e-05	188	36	4	c32d023a69b6da79687ff8fa7485e7499db57046
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 FBN1 MMP2 ADAMTS7	1.57e-05	188	36	4	26915db8863f4115b46a81982e187322e21600fd
ToppCell	P15-Mesenchymal\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS17 FBN1 MMP2 WNT2	1.57e-05	188	36	4	f1ba0b661621a65c91432e62ba73531bdf18e7c1
Computational	Genes upregulated in subsets of cells of a given type within various tumors	CCN2 FBN1 MMP2	1.79e-04	50	24	3	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_1
Computational	Genes upregulated in subsets of cells of a given type within various tumors	HSPG2 MMP2 SPRY4	1.79e-04	50	24	3	GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_1
Computational	Developmental processes.	CCN2 FBN1 EGF WNT2 WNT10B	7.24e-04	333	24	5	MODULE_220
Drug	AC1L1G2K	CNBP HAVCR1 MMP2 EGF	7.35e-06	84	34	4	CID000003498
Drug	aeroplysinin I	MMP2 EGF	1.30e-05	4	34	2	CID000002036
Drug	AC1L2S5J	CNBP APLP1 UHRF2	1.33e-05	31	34	3	CID000127525
Drug	Iamin	CCN6 MMP2 EGF	1.93e-05	35	34	3	CID000073587
Drug	(2S,4R)-methyl-1-acetyl-4-(N-(4-bromophenyl)sulfamoyloxy)pyrrolidine-2-carboxylate	CCN2 MMP2	2.16e-05	5	34	2	ctd:C560356
Drug	nitrofen	CCN2 FBN1 EGF WNT2 SPRY4	2.55e-05	237	34	5	ctd:C007350
Drug	chondroitin sulfate	HSPG2 APLP1 MMP2 EGF ADAMTS7 ADAMTS9	3.00e-05	413	34	6	CID000024766
Drug	AC1L4JRE	APLP1 EGF	3.23e-05	6	34	2	CID000158343
Drug	N-methylmesoporphyrin	CNBP MMP2 WNT1	3.36e-05	42	34	3	CID000444708
Drug	halofuginone	CCN2 ST3GAL2 FBN1 MMP2	3.76e-05	127	34	4	ctd:C010176
Drug	2,3-pentanedione	CCN2 FBN1 MMP2 SORL1	4.00e-05	129	34	4	ctd:C013186
Drug	2e A	CNBP MMP2	4.52e-05	7	34	2	CID011840906
Drug	I50 - 9	MMP2 EGF	6.03e-05	8	34	2	CID000083651
Drug	AC1NRBJE	CNBP HAVCR1 MMP2 EGF	7.58e-05	152	34	4	CID005288446
Drug	TAPI-1	APLP1 MMP2 EGF	8.42e-05	57	34	3	CID009827273
Drug	N-(6-aminohexyl)-1-naphthalenesulfonamide	CNBP MMP2 EGF	8.42e-05	57	34	3	CID000004314
Drug	(2s,5s)-5-Carboxymethylproline	ITGA10 HSPG2 CCN2 ST3GAL2 FBN1	9.68e-05	314	34	5	CID000447989
Drug	Phosphatidylcholines	MMP2 EGF GPX4	1.08e-04	62	34	3	ctd:D010713
Drug	diacerein	CNBP MMP2 WNT2	1.14e-04	63	34	3	CID000026248
Drug	Phenanthrolines	MMP2 EGF	1.18e-04	11	34	2	ctd:D010618
Drug	AC1L1DD6	CNBP HAVCR1 MMP2 EGF	1.42e-04	179	34	4	CID000002299
Drug	Mephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; MCF7; HT_HG-U133A	HSPG2 CCN2 SP110 WNT10B	1.62e-04	185	34	4	4707_UP
Drug	tempol	CCN2 MMP2 GPX4	1.62e-04	71	34	3	ctd:C001803
Drug	2-MeSAMP	CNBP MMP2	1.67e-04	13	34	2	CID000189762
Drug	Phe-glu	CNBP MMP2	1.67e-04	13	34	2	CID000151134
Drug	Solasodine [126-17-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A	THSD4 APLP1 CCN2 ADAMTS7	1.83e-04	191	34	4	3830_UP
Drug	AC1L1B35	APLP1 FBN1 SORL1	1.83e-04	74	34	3	CID000001263
Drug	Mexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A	APLP1 CCN2 MMP2 WNT10B	1.90e-04	193	34	4	3973_DN
Drug	Atovaquone [95233-18-4]; Up 200; 11uM; MCF7; HT_HG-U133A	FBN1 WNT1 WNT10B FRMPD1	1.94e-04	194	34	4	4786_UP
Drug	crocetin	MMP2 GPX4	1.95e-04	14	34	2	ctd:C010561
Drug	D 2163	HSPG2 MMP2	1.95e-04	14	34	2	CID000148203
Drug	PF-00539745-00 [351321-33-0]; Down 200; 10uM; PC3; HT_HG-U133A	THSD4 ST3GAL2 ADAMTS7 FRMPD1	1.98e-04	195	34	4	5979_DN
Drug	Beta-sistosterol [83-46-5]; Down 200; 9.6uM; PC3; HT_HG-U133A	THSD4 HSPG2 ST3GAL2 MMP2	1.98e-04	195	34	4	4073_DN
Drug	Merbromin [129-16-8]; Up 200; 5uM; MCF7; HT_HG-U133A	THSD4 HSPG2 ST3GAL2 MMP2	2.02e-04	196	34	4	4722_UP
Drug	Sotalol hydrochloride [959-24-0]; Down 200; 13uM; PC3; HT_HG-U133A	THSD4 HSPG2 MMP2 WNT10B	2.06e-04	197	34	4	4079_DN
Drug	Ribostamycin sulfate salt [53797-35-6]; Up 200; 7.2uM; MCF7; HT_HG-U133A	ITGA10 APLP1 ST3GAL2 EGF	2.10e-04	198	34	4	6765_UP
Drug	AG-013608 [351320-38-2]; Down 200; 10uM; MCF7; HT_HG-U133A	APLP1 FBN1 EGF ADAMTS9	2.10e-04	198	34	4	6395_DN
Drug	Tranylcypromine hydrochloride [1986-47-6]; Up 200; 23.6uM; MCF7; HT_HG-U133A	THSD4 ITGA10 EGF WNT10B	2.10e-04	198	34	4	5996_UP
Drug	Fluocinonide [356-12-7]; Up 200; 8uM; MCF7; HT_HG-U133A	APLP1 ADAMTS9 SP110 WNT10B	2.14e-04	199	34	4	3839_UP
Drug	Timolol maleate salt [26921-17-5]; Up 200; 9.2uM; MCF7; HT_HG-U133A	ST3GAL2 EGF SP110 WNT10B	2.14e-04	199	34	4	5280_UP
Drug	Amoxapine [14028-44-5]; Up 200; 12.8uM; PC3; HG-U133A	HSPG2 APLP1 ST3GAL2 SP110	2.14e-04	199	34	4	1931_UP
Drug	Clidinium bromide [3485-62-9]; Up 200; 9.2uM; MCF7; HT_HG-U133A	ITGA10 HSPG2 APLP1 WNT10B	2.18e-04	200	34	4	6837_UP
Drug	Gallamine triethiodide [65-29-2]; Up 200; 4.4uM; PC3; HT_HG-U133A	THSD4 CRYGD SP110 WNT1	2.18e-04	200	34	4	5735_UP
Drug	ascorbate-2-phosphate	CCN2 MMP2	2.25e-04	15	34	2	ctd:C011669
Drug	losartan	ITGA10 HSPG2 CCN2 FBN1 MMP2	2.30e-04	378	34	5	CID000003961
Drug	AC1O0UVD	CCN2 MMP2 ADAMTS9	2.49e-04	82	34	3	CID006102706
Disease	Weill-Marchesani syndrome (implicated_via_orthology)	ADAMTS17 FBN1	3.86e-06	3	34	2	DOID:0050475 (implicated_via_orthology)
Disease	Weill-Marchesani syndrome	ADAMTS17 FBN1	7.72e-06	4	34	2	cv:C0265313
Disease	Weill-Marchesani syndrome (is_implicated_in)	ADAMTS17 FBN1	7.72e-06	4	34	2	DOID:0050475 (is_implicated_in)
Disease	Aortic Rupture	FBN1 MMP2	1.29e-05	5	34	2	C0003496
Disease	Aortic Aneurysm, Ruptured	FBN1 MMP2	1.29e-05	5	34	2	C0741160
Disease	Aortic Aneurysm, Thoracic	FBN1 MMP2	2.70e-05	7	34	2	C0162872
Disease	Aortic Aneurysm, Thoracoabdominal	FBN1 MMP2	2.70e-05	7	34	2	C0340630
Disease	Marfan Syndrome, Type I	FBN1 MMP2	4.62e-05	9	34	2	C4721845
Disease	Marfan Syndrome	FBN1 MMP2	7.04e-05	11	34	2	C0024796
Disease	Alveolitis, Fibrosing	CCN2 MMP2 EGF	1.21e-04	83	34	3	C4721507
Disease	Pulmonary Fibrosis	CCN2 MMP2 EGF	1.29e-04	85	34	3	C0034069
Disease	hypertension (biomarker_via_orthology)	HAVCR1 HSPG2 FBN1 MMP2	1.32e-04	227	34	4	DOID:10763 (biomarker_via_orthology)
Disease	glycerate measurement	THSD7B HMCN1	1.34e-04	15	34	2	EFO_0021029
Disease	acute kidney failure (is_marker_for)	HAVCR1 EGF	1.73e-04	17	34	2	DOID:3021 (is_marker_for)
Disease	Malignant neoplasm of breast	MMP2 EGF SP110 WNT10B FRMPD1 SORL1 GPX4	1.89e-04	1074	34	7	C0006142
Disease	aortic measurement	THSD4 FBN1 HMCN1 ADAMTS7	1.94e-04	251	34	4	EFO_0020865
Disease	Liver Cirrhosis	CCN2 FBN1 MMP2	2.28e-04	103	34	3	C0023890
Disease	Fibrosis, Liver	CCN2 FBN1 MMP2	2.42e-04	105	34	3	C0239946
Disease	Hyalinosis, Segmental Glomerular	HAVCR1 CCN2	4.78e-04	28	34	2	C0086432
Disease	primary biliary cholangitis (biomarker_via_orthology)	CCN2 MMP2	4.78e-04	28	34	2	DOID:12236 (biomarker_via_orthology)
Disease	ascending aortic diameter	THSD4 FBN1 HMCN1	5.62e-04	140	34	3	EFO_0021787
Disease	spontaneous coronary artery dissection	THSD4 FBN1	5.87e-04	31	34	2	EFO_0010820
Disease	Cholestasis, Extrahepatic	CCN2 MMP2	6.25e-04	32	34	2	C0005398
Disease	liver cirrhosis (biomarker_via_orthology)	FBN1 MMP2	7.06e-04	34	34	2	DOID:5082 (biomarker_via_orthology)
Disease	Focal glomerulosclerosis	HAVCR1 CCN2	7.92e-04	36	34	2	C0017668

Protein segments in the cluster

Peptide	Gene	Start	Entry
MERWCGGSRSGSCAH	APLP1	116	P51693
AWSMCSRTCGTGARF	ADAMTS17	551	Q8TE56
AWSICSRSCGMGVQS	ADAMTS7	546	Q9UKP4
ESCTSAGRSDGKMWC	MMP2	361	P08253
CMGVSRHCTSSSWSR	HSPG2	926	P98160
MSLRGCTCRVGCSWA	OR10H5	136	Q8NGA6
RSRCWDACMVVDGGT	NADK2	401	Q4G0N4
EFRSCCPGWSAMARS	NEK5	526	Q6P3R8
WGTCSRTCNGGQMRR	HMCN1	4766	Q96RW7
WTPCSRTCGMGISNR	CCN6	216	O95389
WGSCSVSCGVGVMQR	ADAMTS9	1686	Q9P2N4
SRCNSARVDSGCWML	CRYGD	31	P07320
GTAWCSCREGFMKAS	EGF	761	P01133
RMDACCCSVGAAWGT	FBN1	976	P35555
WSACSKTCGMGISTR	CCN2	206	P29279
CTWHFTESRSRLCMG	FRMPD1	1451	Q5SYB0
FMACAPLWSRACGSS	ITGA10	121	O75578
GTMCASRDDWRCARS	GPX4	26	P36969
CGFCRWTSRDVGMAD	DCTN4	111	Q9UJW0
GECSEIMTGAWSCRA	HEXA-AS1	66	Q9H8Q6
SSGMCIRSSWVCDGD	SORL1	1166	Q92673
CSRSNCCARWSFMGA	SPRY4	226	Q9C004
AVTSMCWNRGSCSLF	HAVCR1	41	Q96D42
ACRRCMGDAGASDWF	ST3GAL2	71	Q16842
TCMKWSTNSCGARGA	SLCO1B7	551	G3V0H7
LWSCTFCRMKRSSGS	SP110	571	Q9HB58
CSCGPSSCFVRWAAM	SPRY3	211	O43610
MSSNECFKCGRSGHW	CNBP	1	P62633
WGRGMACVGRTRECT	UHRF2	426	Q96PU4
VSGSCTLRTCWLAMA	WNT2	211	P09544
TFGCFATCRASAWML	TSPAN6	76	O43657
HGMSGSCTVRTCWMR	WNT1	221	P04628
GTSGSCQFKTCWRAA	WNT10B	251	O00744
WTECSQTCGHGGRMS	THSD7B	1256	Q9C0I4
WSMCSKSCQGGFRVR	THSD4	921	Q6ZMP0
MKWSVRGACAALSSC	TMEM271	1	A0A286YF58