Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	triplex DNA binding	DDX12P DDX11L8 DDX11	3.46e-08	4	42	3	GO:0045142
GeneOntologyMolecularFunction	5'-3' DNA helicase activity	DDX12P DDX11L8 DDX11	1.41e-06	11	42	3	GO:0043139
GeneOntologyMolecularFunction	G-quadruplex DNA binding	DDX12P DDX11L8 DDX11	3.10e-06	14	42	3	GO:0051880
GeneOntologyMolecularFunction	DNA replication origin binding	DDX12P DDX11L8 DDX11	6.91e-06	18	42	3	GO:0003688
GeneOntologyMolecularFunction	threonine-tRNA ligase activity	TARS3 TARS1	1.29e-05	3	42	2	GO:0004829
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	PIWIL4 TARS3 DDX12P NIPBL DDX11L8 TARS1 CHD5 DDX11	5.07e-05	645	42	8	GO:0140640
GeneOntologyMolecularFunction	chromatin binding	NCOR2 DDX12P NIPBL DDX11L8 STAT1 CHD5 CGAS DDX11	1.31e-04	739	42	8	GO:0003682
GeneOntologyMolecularFunction	4 iron, 4 sulfur cluster binding	DDX12P DDX11L8 DDX11	1.32e-04	47	42	3	GO:0051539
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	DDX12P DDX11L8 CHD5 DDX11	1.45e-04	127	42	4	GO:0008094
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	DDX12P NIPBL DDX11L8 CHD5 DDX11	2.14e-04	262	42	5	GO:0140097
GeneOntologyMolecularFunction	DNA helicase activity	DDX12P DDX11L8 DDX11	3.00e-04	62	42	3	GO:0003678
GeneOntologyMolecularFunction	helicase activity	DDX12P DDX11L8 CHD5 DDX11	3.34e-04	158	42	4	GO:0004386
GeneOntologyMolecularFunction	inositol trisphosphate phosphatase activity	INPP5A INPP4B	3.87e-04	14	42	2	GO:0046030
GeneOntologyMolecularFunction	iron-sulfur cluster binding	DDX12P DDX11L8 DDX11	5.90e-04	78	42	3	GO:0051536
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DDX12P DDX11L8 DDX11	6.35e-04	80	42	3	GO:0008186
GeneOntologyMolecularFunction	metal cluster binding	DDX12P DDX11L8 DDX11	7.07e-04	83	42	3	GO:0051540
GeneOntologyMolecularFunction	inositol phosphate phosphatase activity	INPP5A INPP4B	8.01e-04	20	42	2	GO:0052745
GeneOntologyMolecularFunction	tau-protein kinase activity	TAOK2 TAOK1	9.71e-04	22	42	2	GO:0050321
GeneOntologyMolecularFunction	single-stranded RNA binding	DDX12P DDX11L8 DDX11	1.64e-03	111	42	3	GO:0003727
GeneOntologyMolecularFunction	ATP-dependent activity	KIF28P ACSM4 DDX12P DDX11L8 CHD5 DDX11	1.69e-03	614	42	6	GO:0140657
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	PIWIL4 TARS3 DDX12P DDX11L8 TARS1	1.75e-03	417	42	5	GO:0140098
GeneOntologyMolecularFunction	ATP hydrolysis activity	KIF28P DDX12P DDX11L8 CHD5 DDX11	2.23e-03	441	42	5	GO:0016887
GeneOntologyMolecularFunction	enzyme activator activity	TAOK2 TAOK1 GNAQ AIM2 GTF3C4 B3GAT3	2.35e-03	656	42	6	GO:0008047
GeneOntologyMolecularFunction	single-stranded DNA binding	DDX12P DDX11L8 DDX11	2.80e-03	134	42	3	GO:0003697
GeneOntologyMolecularFunction	ligase activity, forming carbon-oxygen bonds	TARS3 TARS1	3.53e-03	42	42	2	GO:0016875
GeneOntologyMolecularFunction	aminoacyl-tRNA ligase activity	TARS3 TARS1	3.53e-03	42	42	2	GO:0004812
GeneOntologyMolecularFunction	histone deacetylase binding	NCOR2 NIPBL CHD5	3.64e-03	147	42	3	GO:0042826
GeneOntologyMolecularFunction	tau protein binding	TAOK2 TAOK1	4.22e-03	46	42	2	GO:0048156
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KIF28P DDX12P GNAQ DDX11L8 CHD5 DDX11	5.34e-03	775	42	6	GO:0017111
GeneOntologyMolecularFunction	ligase activity	TARS3 ACSM4 TARS1	5.82e-03	174	42	3	GO:0016874
GeneOntologyMolecularFunction	pyrophosphatase activity	KIF28P DDX12P GNAQ DDX11L8 CHD5 DDX11	7.79e-03	839	42	6	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	KIF28P DDX12P GNAQ DDX11L8 CHD5 DDX11	7.83e-03	840	42	6	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	KIF28P DDX12P GNAQ DDX11L8 CHD5 DDX11	7.83e-03	840	42	6	GO:0016818
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	GNAQ PDE6A INPP5A INPP4B	8.62e-03	386	42	4	GO:0042578
GeneOntologyBiologicalProcess	establishment of sister chromatid cohesion	DDX12P NIPBL DDX11L8 DDX11	4.39e-09	11	41	4	GO:0034085
GeneOntologyBiologicalProcess	sister chromatid cohesion	DDX12P NIPBL DDX11L8 DDX11	9.41e-06	67	41	4	GO:0007062
GeneOntologyBiologicalProcess	threonyl-tRNA aminoacylation	TARS3 TARS1	1.16e-05	3	41	2	GO:0006435
GeneOntologyBiologicalProcess	positive regulation of defense response to virus by host	AIM2 STAT1 CGAS	5.86e-05	38	41	3	GO:0002230
GeneOntologyCellularComponent	Ctf18 RFC-like complex	DDX12P DDX11L8 DDX11	8.96e-07	10	42	3	GO:0031390
MousePheno	increased allantois apoptosis	DDX12P DDX11L8 DDX11	6.66e-07	8	33	3	MP:0003891
MousePheno	absent paraxial mesoderm	DDX12P DDX11L8 DDX11	9.97e-07	9	33	3	MP:0012184
MousePheno	decreased paraxial mesoderm size	DDX12P DDX11L8 DDX11	2.60e-06	12	33	3	MP:0012183
MousePheno	small allantois	DDX12P DDX11L8 DDX11	6.57e-06	16	33	3	MP:0004559
MousePheno	placental labyrinth hypoplasia	DDX12P DDX11L8 DDX11	1.33e-05	20	33	3	MP:0001715
MousePheno	abnormal amniotic cavity morphology	DDX12P DDX11L8 DDX11	2.66e-05	25	33	3	MP:0011199
MousePheno	abnormal chromosome number	DDX12P NIPBL DDX11L8 DDX11	4.77e-05	86	33	4	MP:0004023
MousePheno	wavy neural tube	DDX12P DDX11L8 DDX11	8.82e-05	37	33	3	MP:0000930
MousePheno	abnormal paraxial mesoderm morphology	DDX12P DDX11L8 DDX11	1.12e-04	40	33	3	MP:0008029
MousePheno	absent somites	DDX12P DDX11L8 DDX11	1.29e-04	42	33	3	MP:0006386
MousePheno	failure of heart looping	DDX12P DDX11L8 DDX11	1.39e-04	43	33	3	MP:0004251
MousePheno	abnormal chromosome morphology	DDX12P NIPBL DDX11L8 DDX11	2.10e-04	126	33	4	MP:0003702
MousePheno	failure of somite differentiation	DDX12P DDX11L8 DDX11	2.18e-04	50	33	3	MP:0001690
MousePheno	decreased placental labyrinth size	DDX12P DDX11L8 DDX11	2.45e-04	52	33	3	MP:0011521
MousePheno	kinked neural tube	DDX12P DDX11L8 DDX11	3.22e-04	57	33	3	MP:0003400
MousePheno	abnormal placenta labyrinth size	DDX12P DDX11L8 DDX11	3.74e-04	60	33	3	MP:0011519
MousePheno	increased susceptibility to Herpesvirales infection	AIM2 STAT1 CGAS	3.93e-04	61	33	3	MP:0020916
MousePheno	aneuploidy	DDX12P DDX11L8 DDX11	3.93e-04	61	33	3	MP:0004024
MousePheno	failure of chorioallantoic fusion	DDX12P DDX11L8 DDX11	5.18e-04	67	33	3	MP:0009657
MousePheno	increased susceptibility to Poxviridae infection	AIM2 CGAS	5.57e-04	15	33	2	MP:0020928
MousePheno	decreased inner cell mass proliferation	DDX12P DDX11L8 DDX11	5.65e-04	69	33	3	MP:0012113
MousePheno	abnormal inner cell mass proliferation	DDX12P DDX11L8 DDX11	6.66e-04	73	33	3	MP:0004966
MousePheno	abnormal susceptibility to Poxviridae infection	AIM2 CGAS	7.19e-04	17	33	2	MP:0020927
MousePheno	abnormal afterhyperpolarization	KCNQ3 GNAQ	7.19e-04	17	33	2	MP:0003412
MousePheno	increased osteoclast cell number	NCOR2 STAT1 INPP4B	7.78e-04	77	33	3	MP:0004984
MousePheno	abnormal mesenchyme morphology	DDX12P DDX11L8 DDX11	8.70e-04	80	33	3	MP:0006301
MousePheno	abnormal cell nucleus morphology	DDX12P NIPBL DDX11L8 DDX11	8.82e-04	184	33	4	MP:0003111
MousePheno	abnormal susceptibility to Herpesvirales infection	AIM2 STAT1 CGAS	9.68e-04	83	33	3	MP:0020915
MousePheno	abnormal placenta labyrinth morphology	DDX12P NIPBL DDX11L8 DDX11	1.07e-03	194	33	4	MP:0001716
MousePheno	abnormal cell cycle	PIWIL4 DDX12P DDX11L8 STAT1 B3GAT3 DDX11	1.21e-03	520	33	6	MP:0003077
MousePheno	abnormal chorioallantoic fusion	DDX12P DDX11L8 DDX11	1.22e-03	90	33	3	MP:0002824
MousePheno	abnormal placenta morphology	NCOR2 DDX12P DNAJC8 NIPBL DDX11L8 DDX11	1.27e-03	525	33	6	MP:0001711
MousePheno	abnormal placenta physiology	DDX12P NIPBL DDX11L8 DDX11	1.29e-03	204	33	4	MP:0010038
MousePheno	abnormal embryo size	CUL1 DDX12P ZNF148 TM9SF2 NIPBL INPP5A DDX11L8 DDX11	1.39e-03	956	33	8	MP:0001697
Domain	ThrRS_core	TARS3 TARS1	1.21e-05	3	38	2	IPR033728
Domain	Thr-tRNA-ligase_IIa	TARS3 TARS1	1.21e-05	3	38	2	IPR002320
Domain	MAGE	MAGEB5 MAGEB4 MAGED1	4.45e-05	34	38	3	SM01373
Domain	MAGE	MAGEB5 MAGEB4 MAGED1	5.30e-05	36	38	3	PS50838
Domain	MHD_dom	MAGEB5 MAGEB4 MAGED1	5.30e-05	36	38	3	IPR002190
Domain	MAGE	MAGEB5 MAGEB4 MAGED1	5.30e-05	36	38	3	PF01454
Domain	TGS	TARS3 TARS1	6.02e-05	6	38	2	IPR004095
Domain	TGS	TARS3 TARS1	6.02e-05	6	38	2	PF02824
Domain	TGS-like	TARS3 TARS1	8.41e-05	7	38	2	IPR012676
Domain	tRNA_SAD	TARS3 TARS1	8.41e-05	7	38	2	SM00863
Domain	tRNA_SAD	TARS3 TARS1	8.41e-05	7	38	2	IPR012947
Domain	tRNA_SAD	TARS3 TARS1	8.41e-05	7	38	2	PF07973
Domain	Thr/Ala-tRNA-synth_IIc_edit	TARS3 TARS1	1.12e-04	8	38	2	IPR018163
Domain	HGTP_anticodon	TARS3 TARS1	1.44e-04	9	38	2	PF03129
Domain	aa-tRNA-synt_IIb	TARS3 TARS1	2.19e-04	11	38	2	IPR002314
Domain	tRNA-synt_2b	TARS3 TARS1	2.19e-04	11	38	2	PF00587
Domain	-	TARS3 TARS1	2.19e-04	11	38	2	3.40.50.800
Domain	Anticodon-bd	TARS3 TARS1	3.61e-04	14	38	2	IPR004154
Domain	Beta-grasp_dom	TARS3 TARS1	3.61e-04	14	38	2	IPR012675
Domain	-	TARS3 TARS1	3.61e-04	14	38	2	3.10.20.30
Domain	aa-tRNA-synth_II	TARS3 TARS1	6.04e-04	18	38	2	IPR006195
Domain	AA_TRNA_LIGASE_II	TARS3 TARS1	6.04e-04	18	38	2	PS50862
Domain	DNA/RNA_helicase_DEAH_CS	CHD5 DDX11	2.30e-03	35	38	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD5 DDX11	2.71e-03	38	38	2	PS00690
Pubmed	Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.	DDX12P DDX11L8 DDX11	1.64e-09	3	42	3	17611414
Pubmed	Mammalian ChlR1 has a role in heterochromatin organization.	DDX12P DDX11L8 DDX11	1.64e-09	3	42	3	21854770
Pubmed	The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.	DDX12P DDX11L8 DDX11	9.13e-08	8	42	3	22678773
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	CUL1 MAGED1 TARS1 GTF3C4	1.11e-06	64	42	4	26511642
Pubmed	An overview of the MAGE gene family with the identification of all human members of the family.	MAGEB5 MAGEB4 MAGED1	1.32e-06	18	42	3	11454705
Pubmed	Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE.	AIM2 STAT1	1.42e-06	2	42	2	21943709
Pubmed	Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.	TARS3 TARS1	1.42e-06	2	42	2	37059185
Pubmed	A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.	TARS3 TARS1	1.42e-06	2	42	2	29579307
Pubmed	Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.	DDX12P DDX11	1.42e-06	2	42	2	32855419
Pubmed	Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.	TAOK2 TAOK1	1.42e-06	2	42	2	28830982
Pubmed	Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA.	DDX12P DDX11	1.42e-06	2	42	2	8833153
Pubmed	Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1.	DDX12P DDX11	1.42e-06	2	42	2	9013641
Pubmed	Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.	STAT1 CGAS	1.42e-06	2	42	2	24284630
Pubmed	Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.	TAOK2 TAOK1	4.27e-06	3	42	2	9786855
Pubmed	TAO kinases mediate activation of p38 in response to DNA damage.	TAOK2 TAOK1	4.27e-06	3	42	2	17396146
Pubmed	AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-κB activation in oral squamous cell carcinoma.	AIM2 STAT1	4.27e-06	3	42	2	38166970
Pubmed	The Trinity of cGAS, TLR9, and ALRs Guardians of the Cellular Galaxy Against Host-Derived Self-DNA.	AIM2 CGAS	4.27e-06	3	42	2	33643304
Pubmed	Microglial AIM2 alleviates antiviral-related neuro-inflammation in mouse models of Parkinson's disease.	AIM2 CGAS	4.27e-06	3	42	2	35959803
Pubmed	Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.	TAOK2 TAOK1	4.27e-06	3	42	2	23585562
Pubmed	AIM2 inflammasome regulated by the IFN-γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease.	AIM2 STAT1	8.53e-06	4	42	2	38869352
Pubmed	Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor.	AIM2 CGAS	8.53e-06	4	42	2	28947539
Pubmed	IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway.	AIM2 CGAS	8.53e-06	4	42	2	38860764
Pubmed	AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.	AIM2 CGAS	8.53e-06	4	42	2	33710283
Pubmed	Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein.	AIM2 STAT1	8.53e-06	4	42	2	21551362
Pubmed	Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.	TAOK2 TAOK1	8.53e-06	4	42	2	10497253
Pubmed	Analysis of mouse embryonic patterning and morphogenesis by forward genetics.	DDX12P DDX11L8 DDX11	8.71e-06	33	42	3	15755804
Pubmed	Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells.	MAGEB5 MAGEB4 MAGED1	8.71e-06	33	42	3	31143371
Pubmed	Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.	TAOK2 TAOK1	1.42e-05	5	42	2	13679851
Pubmed	PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion.	NIPBL DDX11	1.42e-05	5	42	2	37592094
Pubmed	Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.	TAOK2 TAOK1	1.42e-05	5	42	2	22683681
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	NCOR2 ZNF148 MAGED1 TARS1 GTF3C4 STAT1	1.49e-05	444	42	6	34795231
Pubmed	AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity.	AIM2 CGAS	2.13e-05	6	42	2	27462105
Pubmed	Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.	AIM2 CGAS	2.13e-05	6	42	2	29203515
Pubmed	The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.	TAOK2 TAOK1	2.13e-05	6	42	2	12639963
Pubmed	Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.	TAOK2 TAOK1	2.13e-05	6	42	2	16893890
Pubmed	The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.	AIM2 CGAS	3.97e-05	8	42	2	27496731
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	CUL1 NCOR2 PSMD12 ZNF148 DNAJC8 NIPBL TARS1 STAT1	4.51e-05	1103	42	8	34189442
Pubmed	Nuclear monomeric integrin αv in cancer cells is a coactivator regulated by thyroid hormone.	NCOR2 STAT1	5.10e-05	9	42	2	23640055
Pubmed	Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.	AIM2 CGAS	5.10e-05	9	42	2	30170814
Pubmed	Cellular substrates and pro-apoptotic function of the human HtrA4 protease.	TAOK1 PSMD12 DNAJC8 GTF3C4	5.71e-05	173	42	4	31470122
Pubmed	A noncanonical function of cGAMP in inflammasome priming and activation.	AIM2 CGAS	9.32e-05	12	42	2	29030458
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	NCOR2 PDE6A MAGED1 CFAP20 GTF3C4	1.12e-04	396	42	5	26687479
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	CUL1 PSMD12 DDX12P MAGED1 TARS1 GTF3C4 STAT1 DDX11	1.12e-04	1257	42	8	37317656
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TAOK1 TARS3 MAGED1 NIPBL TARS1 GTF3C4 STAT1 RYR3	1.31e-04	1285	42	8	35914814
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOR2 ZNF148 NIPBL	1.41e-04	83	42	3	28794006
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CUL1 TAOK1 PSMD12 GTF3C4 STAT1 CGAS	1.69e-04	689	42	6	36543142
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	SLC44A2 NCOR2 MAGED1 TM9SF2 DNAJC8 B3GAT3	1.80e-04	697	42	6	28298427
Pubmed	Genomic analysis of mouse retinal development.	TAOK2 CUL1 KCNQ3 NCOR2 DNAJC8 CFAP20 CGAS	1.85e-04	1006	42	7	15226823
Pubmed	The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.	AIM2 STAT1	1.91e-04	17	42	2	25774715
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CUL1 NCOR2 DNAJC8 NIPBL TARS1 GTF3C4 STAT1	1.94e-04	1014	42	7	32416067
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	SLC44A2 TAOK1 PSMD12 GNAQ NIPBL SERPINA5 CFAP20	1.96e-04	1016	42	7	19056867
Pubmed	Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.	SLC44A2 PSMD12 PDE6A STAT1	2.32e-04	249	42	4	30097533
Pubmed	Human transcription factor protein interaction networks.	NCOR2 R3HDM2 PSMD12 ZNF148 MAGED1 NIPBL STAT1 CHD5	2.70e-04	1429	42	8	35140242
Pubmed	TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14.	MAGED1 STAT1	3.54e-04	23	42	2	29581427
Pubmed	IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.	AIM2 CGAS	3.54e-04	23	42	2	29576451
Pubmed	Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1.	CUL1 PSMD12	3.86e-04	24	42	2	29871923
Pubmed	Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor.	AIM2 CGAS	3.86e-04	24	42	2	34526512
Pubmed	ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.	AIM2 STAT1	4.20e-04	25	42	2	27917412
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	CUL1 ACSM4 PSMD12 PDE6A	4.93e-04	304	42	4	32235678
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	CUL1 NCOR2 ZNF148 CFAP20 GTF3C4 STAT1	5.41e-04	857	42	6	25609649
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	CUL1 NCOR2 TAOK1 PSMD12 NIPBL	6.58e-04	582	42	5	20467437
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CUL1 NCOR2 PSMD12 PDHA2 CFAP20 TARS1 STAT1	6.73e-04	1247	42	7	27684187
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	ZNF148 NIPBL CHD5	6.95e-04	143	42	3	32560809
Pubmed	Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility.	PSMD12 MAGED1	7.34e-04	33	42	2	17558393
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	NCOR2 R3HDM2 MAGED1	8.29e-04	152	42	3	38360978
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	TAOK1 PSMD12 ZNF148 NIPBL CFAP20 STAT1 CGAS	9.32e-04	1318	42	7	30463901
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	CUL1 PSMD12 ZNF148 MAGED1 PDHA2 TARS1 GTF3C4	1.00e-03	1335	42	7	29229926
Pubmed	Roles of tau protein in health and disease.	TAOK2 TAOK1	1.08e-03	40	42	2	28386764
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CUL1 NCOR2 NIPBL TARS1 GTF3C4 STAT1 CGAS	1.09e-03	1353	42	7	29467282
Pubmed	Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.	PSMD12 DNAJC8 TARS1 STAT1	1.10e-03	377	42	4	25147182
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	CUL1 NCOR2 MAGED1 CFAP20 GTF3C4	1.12e-03	655	42	5	35819319
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	TAOK2 CUL1 TAOK1 SERPINA5 CFAP20 GTF3C4 STAT1	1.17e-03	1371	42	7	36244648
Cytoband	Xp21.3	MAGEB5 MAGEB4	3.27e-04	29	42	2	Xp21.3
Cytoband	5p13.2	NIPBL TARS1	3.74e-04	31	42	2	5p13.2
Cytoband	12p13.31	ACSM4 DDX12P	2.47e-03	80	42	2	12p13.31
Cytoband	Ensembl 112 genes in cytogenetic band chrXp21	MAGEB5 MAGEB4	2.72e-03	84	42	2	chrXp21
Cytoband	Ensembl 112 genes in cytogenetic band chr12p13	ACSM4 DDX12P DDX11L8	4.14e-03	353	42	3	chr12p13
GeneFamily	MAGE family	MAGEB5 MAGEB4 MAGED1	4.76e-05	40	32	3	1136
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK2 TAOK1	8.17e-04	24	32	2	654
GeneFamily	Phosphoinositide phosphatases	INPP5A INPP4B	1.46e-03	32	32	2	1079
GeneFamily	DEAD-box helicases	DDX12P DDX11	2.50e-03	42	32	2	499
Coexpression	GSE28237_FOLLICULAR_VS_EARLY_GC_BCELL_UP	NCOR2 TARS1 STAT1 B3GAT3 VPS8	1.66e-05	200	42	5	M4884
Disease	Warsaw breakage syndrome (implicated_via_orthology)	DDX12P DDX11L8 DDX11	2.49e-09	3	41	3	DOID:0060535 (implicated_via_orthology)
Disease	amino acid metabolic disorder (implicated_via_orthology)	TARS3 TARS1	1.13e-05	4	41	2	DOID:9252 (implicated_via_orthology)
Disease	central nervous system disease (implicated_via_orthology)	TAOK2 TAOK1	2.23e-04	16	41	2	DOID:331 (implicated_via_orthology)
Disease	response to methotrexate	ZNF148 INPP4B	2.23e-04	16	41	2	GO_0031427
Disease	factor VIII measurement, venous thromboembolism	SLC44A2 GTF3C4	1.03e-03	34	41	2	EFO_0004286, EFO_0004630
Disease	Craniofacial Abnormalities	GNAQ NIPBL B3GAT3	1.33e-03	156	41	3	C0376634
Disease	Congenital Heart Defects	GNAQ NIPBL	1.72e-03	44	41	2	C0018798
Disease	colorectal health	FBXO39 GNAQ DDX11	2.74e-03	201	41	3	EFO_0008460

Protein segments in the cluster

Peptide	Gene	Start	Entry
MKLKLKNVFLAYFLV	B3GAT3	1	O94766
YLEMKNKFLARRFKL	CHD5	1781	Q8TDI0
IRIFQKLNYMLLAKR	AIM2	66	O14862
MLVQKDLKRYKFKSL	ACSM4	326	P0C7M7
KLMKYLLEQLKERFK	CGAS	411	Q8N884
FKLRMAKKNYDLRIL	R3HDM2	956	Q9Y2K5
LFLNKKDLLEEKIMY	GNAQ	271	P50148
KINQAMRKKLILYFK	NCOR2	271	Q9Y618
RKTKMLVQFLLYKYK	MAGEB4	111	O15481
LLEQFLLYKFKMKQR	MAGEB5	46	Q9BZ81
LLYKFKMKQRILKED	MAGEB5	51	Q9BZ81
LQERANKLVKYLMLK	MAGED1	471	Q9Y5V3
LVMIIKNLKKYFTFE	CFAP20	76	Q9Y6A4
KNIKCRKYAFNMLQL	INPP4B	891	O15327
AVRILQFRLYKKKFK	KCNQ3	521	O43525
IQFMFYEGLKRQLLK	SLC25A17	181	O43808
KVMLQLEKKLFDYFN	INPP5A	276	Q14642
LALYFKKRTMFQKIV	PDE6A	671	P16499
FLKKMGKRLDYLNLK	FBXO39	156	Q8N4B4
KRSIVKQYLDFKLLM	NIPBL	2611	Q6KC79
KLKLKYYNLMIQLDQ	PSMD12	221	O00232
KRLKAKNLMYLKQIL	DDX11	431	Q96FC9
KNLMYLKQILYLLEK	DDX11	436	Q96FC9
VFQKFYAKMLAKRLV	CUL1	461	Q13616
LKMFKKRQLELYLPK	SERPINA5	291	P05154
KAKNLMYLKQILYLL	DDX11L8	436	A8MPP1
RLKAKNLMYLKQILY	DDX12P	451	Q92771
ELFKQAVYKQTMKLF	DNAJC8	156	O75937
LEKFIKFLNRNAYIM	SLC44A2	551	Q8IWA5
KYLKFLDQLSQKMKL	CCDC170	431	Q8IYT3
NKLLKNVAFMKSYIL	CYP2C9	231	P11712
KAKFINRKFLMQELY	KIF28P	596	B7ZC32
RMELKADQLYKQKFI	PDHA2	71	P29803
LEMFKYNKFKCRILN	TARS3	306	A2RTX5
LLAMFKYNKFKCRIL	TARS1	226	P26639
QLLLKKMYLMLDNKR	STAT1	196	P42224
FNIIFRKILKKLSMY	PIWIL4	206	Q7Z3Z4
NLQYRKMKKLLFQEA	TAOK1	306	Q7L7X3
NLQYRKMKKILFQEA	TAOK2	306	Q9UL54
LQRKDLLFSQMYDKL	VPS8	591	Q8N3P4
SMEKRFAYKFLKKIL	RYR3	2811	Q15413
FKLFLLRILYQSMQK	GTF3C4	576	Q9UKN8
KQKLEFLKKSMLLNY	TM9SF2	136	Q99805
DAMQFLKKKRYLQAA	ZNF148	466	Q9UQR1