Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	poly(A) binding	HNRNPDL RBMS3	3.07e-04	29	18	2	GO:0008143
GeneOntologyMolecularFunction	poly-purine tract binding	HNRNPDL RBMS3	5.02e-04	37	18	2	GO:0070717
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	DDX21 ZGRF1 ALKBH8 DCP2	2.30e-03	645	18	4	GO:0140640
Domain	Nucleotide-bd_a/b_plait	HNRNPDL DDX21 RBMS3 RBM27 ALKBH8	3.58e-06	258	18	5	IPR012677
Domain	RRM	HNRNPDL RBMS3 RBM27 ALKBH8	5.99e-05	230	18	4	PS50102
Domain	-	HNRNPDL RBMS3 RBM27 ALKBH8	7.53e-05	244	18	4	3.30.70.330
Domain	RRM_1	HNRNPDL RBMS3 RBM27	9.82e-04	208	18	3	PF00076
Domain	zf-CCCH	RBM27 PARP12	1.00e-03	49	18	2	PF00642
Domain	RRM	HNRNPDL RBMS3 RBM27	1.11e-03	217	18	3	SM00360
Domain	RRM_dom	HNRNPDL RBMS3 RBM27	1.26e-03	227	18	3	IPR000504
Domain	Znf_CCCH	RBM27 PARP12	1.40e-03	58	18	2	IPR000571
Domain	ZF_C3H1	RBM27 PARP12	1.40e-03	58	18	2	PS50103
Pathway	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	CDK8 E2F5	2.52e-04	26	13	2	MM14878
Pathway	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	CDK8 E2F5	4.86e-04	36	13	2	M633
Pathway	WP_MRNA_PROCESSING	HNRNPDL DDX21 RBMS3 ALKBH8	5.87e-04	451	13	4	MM15946
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	CDK8 E2F5	6.31e-04	41	13	2	MM14876
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	CDK8 E2F5	9.76e-04	51	13	2	M665
Pathway	REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY	CNOT10 DCP2	1.09e-03	54	13	2	MM15089
Pathway	REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY	CNOT10 DCP2	1.18e-03	56	13	2	M839
Pathway	KEGG_RNA_DEGRADATION	CNOT10 DCP2	1.30e-03	59	13	2	M963
Pathway	REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	CDK8 E2F5	2.21e-03	77	13	2	MM14670
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	HNRNPDL DDX21 RBMS3 RBM27 CNOT10 RRBP1	1.20e-06	724	18	6	36232890
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	HNRNPDL DDX21 CNOT10 SPAG9 DCP2 RRBP1	1.74e-05	1155	18	6	20360068
Pubmed	Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.	CDK8 STK35	2.29e-05	14	18	2	24811271
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	HNRNPDL RBMS3 RBM27 ALKBH8	2.67e-05	347	18	4	16033648
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	HNRNPDL DDX21 PARP12 RRBP1	8.11e-05	462	18	4	31138677
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	DDX21 RBM27 SPAG9 PARP12 RRBP1	8.85e-05	934	18	5	33916271
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	DDX21 RBM27 RRBP1	1.03e-04	179	18	3	36261009
Pubmed	Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation.	DDX21 RRBP1	1.95e-04	40	18	2	16210410
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	HNRNPDL DDX21 RRBP1	1.98e-04	223	18	3	20020773
Pubmed	O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.	DDX21 TTLL6 RRBP1	2.90e-04	254	18	3	36604567
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CDK8 RBM27 CNOT10 SPAG9	2.92e-04	645	18	4	25281560
Pubmed	Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.	HNRNPDL DDX21	3.30e-04	52	18	2	24591637
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	HNRNPDL DDX21 RRBP1	3.50e-04	271	18	3	32433965
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	HNRNPDL DDX21 RBM27 CNOT10	3.52e-04	678	18	4	30209976
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	DDX21 RBM27 RRBP1	3.62e-04	274	18	3	34244482
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	HNRNPDL DDX21 CNOT10 SPAG9 RRBP1	3.90e-04	1284	18	5	17353931
Pubmed	Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.	DDX21 RBM27 RRBP1	4.49e-04	295	18	3	26209609
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	TTLL6 SPAG9	1.45e-02	473	18	2	chr17q21
GeneFamily	RNA binding motif containing	HNRNPDL RBMS3 RBM27 ALKBH8	1.71e-05	213	14	4	725
GeneFamily	Zinc fingers CCCH-type	RBM27 PARP12	3.26e-04	35	14	2	73
ToppCell	PBMC-Mild\|PBMC / Compartment, Disease Groups and Clusters	DDX21 SPAG9 PARP12 RRBP1	9.78e-07	194	18	4	d1366b169d14011194e61d16b6b0953349febc78
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1D ZGRF1 E2F5	3.34e-05	158	18	3	6d2709b387945c015faa223c20d22b52a4082140
ToppCell	Ionocyte-iono-2\|World / Class top	CDK8 CACNA1D CFTR	4.37e-05	173	18	3	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	droplet-Marrow-BM\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK8 HNRNPDL PARP12	5.00e-05	181	18	3	4169a1527b9c8f5783b8cc44e3a3924f8ed9a5e2
ToppCell	5'-Adult-Appendix\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HNRNPDL DDX21 RBMS3	6.33e-05	196	18	3	a579211ef14f348d0c5a290553150222dfbf1515
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	DDX21 SPAG9 PARP12	6.52e-05	198	18	3	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DDX21 SPAG9 PARP12	6.52e-05	198	18	3	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	Brain_organoid-organoid_Tanaka_cellReport\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	RBMS3 RBM27 RRBP1	6.72e-05	200	18	3	b0ba486b55be18a4236bd2644f02352651f4b1fe
Drug	Parthenolide [20554-84-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A	SPAG9 CFTR RRBP1	3.87e-04	184	18	3	5530_UP
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	HNRNPDL PARP12 RRBP1	4.13e-04	188	18	3	5224_DN
Drug	Hycanthone [3105-97-3]; Down 200; 11.2uM; MCF7; HT_HG-U133A	CACNA1D E2F5 PARP12	4.46e-04	193	18	3	3229_DN
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; MCF7; HT_HG-U133A	HNRNPDL CACNA1D SPAG9	4.52e-04	194	18	3	2293_DN
Drug	Labetalol hydrochloride [32780-64-6]; Down 200; 11uM; MCF7; HT_HG-U133A	CACNA1D PARP12 RRBP1	4.66e-04	196	18	3	3167_DN
Drug	Dosulepin hydrochloride [897-15-4]; Down 200; 12uM; HL60; HG-U133A	RBMS3 SPAG9 PARP12	4.73e-04	197	18	3	1713_DN
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; HL60; HG-U133A	RBMS3 PARP12 RRBP1	4.73e-04	197	18	3	1591_UP
Drug	Mefenamic acid [61-68-7]; Up 200; 16.6uM; MCF7; HT_HG-U133A	CACNA1D PARP12 RRBP1	4.87e-04	199	18	3	5534_UP
Drug	Sulfabenzamide [127-71-9]; Up 200; 14.4uM; HL60; HT_HG-U133A	RBMS3 CFTR RRBP1	4.94e-04	200	18	3	2159_UP
Drug	AR E	HNRNPDL E2F5 DCP2	7.42e-04	230	18	3	CID004369394
Disease	alcohol consumption measurement	CDK8 RBMS3 RBM27 CACNA1D TTLL6	7.10e-04	1242	18	5	EFO_0007878
Disease	aspartate aminotransferase measurement	RBMS3 RBM27 STK35 RRBP1	1.90e-03	904	18	4	EFO_0004736
Disease	corneal resistance factor	RBMS3 STK35 TTLL6	2.44e-03	451	18	3	EFO_0010067
Disease	response to vaccine	CDK8 STK35	2.48e-03	122	18	2	EFO_0004645
Disease	Global developmental delay	CDK8 ALKBH8	2.94e-03	133	18	2	C0557874
Disease	dyslexia	CDK8 RBMS3	4.33e-03	162	18	2	EFO_0005424
Disease	coronary artery disease	CDK8 CFTR PARP12 RRBP1	5.18e-03	1194	18	4	EFO_0001645
Disease	dental caries	RBMS3 ZGRF1	5.72e-03	187	18	2	EFO_0003819

Protein segments in the cluster

Peptide	Gene	Start	Entry
KAKQNNNNRKTSNGD	CFTR	411	P13569
NKQKSKYLRGNRNSQ	ALKBH8	511	Q96BT7
NGRKQYQDSPNQKKR	DCP2	321	Q8IU60
QGNNNQNKPGFLRKN	RBM27	581	Q9P2N5
GQKKRQNQSKYTQNG	RBMS3	226	Q6XE24
KEVYRQQQQQQKGGR	HNRNPDL	311	O14979
PQKYKQVTNGQGENK	SPAG9	651	O60271
GGNRVNNAKNKRTNN	KIAA1109	2631	Q2LD37
YQWQKGQMQKQNGGK	PARP12	541	Q9H0J9
GQNGQKKYQINLKSH	E2F5	206	Q15329
KTEGYRKQQQRQQQQ	C9orf43	286	Q8TAL5
GGNKSNRSQNKGQKR	DDX21	761	Q9NR30
DKGDKKNQQQQQGNN	CDK8	366	P49336
QQYAKSKKQGNSSNS	CACNA1D	86	Q01668
KNGKNETGNNNNKDG	CNOT10	186	Q9H9A5
KEGNQDNKNVNVNKY	STK35	396	Q8TDR2
QNQGKKAEGAQNQGK	RRBP1	306	Q9P2E9
QNQGKKGEGAQNQGK	RRBP1	316	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	326	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	336	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	346	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	356	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	366	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	376	Q9P2E9
QNQGKKVEGAQNQGK	RRBP1	386	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	396	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	406	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	416	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	426	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	436	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	446	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	456	Q9P2E9
QNQGKKVEGAQNQGK	RRBP1	466	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	476	Q9P2E9
QNQGKKAEGAQNQGK	RRBP1	486	Q9P2E9
AQNGLQNAQQQGKKK	TTLL6	41	Q8N841
KKKNTVFQQGTQQTY	ZGRF1	846	Q86YA3