Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

COL4A2 SLIT2 FBN1 VWF LAMA2 CRELD2 TECTA SSPOP AGRN TNXB FBN3

2.63e-101888111GO:0005201
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP10 LRP1 LRP1B LRP8 SORL1

4.09e-0916815GO:0005041
GeneOntologyMolecularFunctioncalcium ion binding

SLIT2 FBN1 MEGF6 DLL4 ENPP3 LRP1 LRP4 CRELD2 DSG4 DLK1 PLCH1 LRP1B AGRN FBN3 NOTCH3 NOTCH4 LRP8

6.53e-097498117GO:0005509
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP10 LRP1 LRP1B LRP8 SORL1

1.87e-0821815GO:0030228
GeneOntologyMolecularFunctioncargo receptor activity

LRP10 LRP1 LRP1B LGALS3BP LRP8 SORL1

1.25e-0685816GO:0038024
GeneOntologyMolecularFunctionapolipoprotein binding

LRP1 LRP4 LRP8

6.97e-0520813GO:0034185
GeneOntologyMolecularFunctionhistone H4K20 demethylase activity

PHF2 KDM7A

9.70e-054812GO:0035575
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

PHF2 KDM5B KDM7A PLOD1 NOS1 FMO6P

1.38e-04194816GO:0016705
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

PHF2 KDM5B KDM7A PLOD1

1.41e-0465814GO:0016706
GeneOntologyMolecularFunctionhistone H4 demethylase activity

PHF2 KDM7A

1.61e-045812GO:0141058
GeneOntologyMolecularFunctionhistone H3 demethylase activity

PHF2 KDM5B KDM7A

1.96e-0428813GO:0141052
GeneOntologyMolecularFunctionheparan sulfate proteoglycan binding

SLIT2 LRP1 AGRN

2.18e-0429813GO:0043395
GeneOntologyMolecularFunctionstructural molecule activity

COL4A2 SLIT2 FBN1 VWF LAMA2 CRELD2 EVPL TECTA SSPOP AGRN TNXB FBN3

2.40e-048918112GO:0005198
GeneOntologyMolecularFunctionhistone demethylase activity

PHF2 KDM5B KDM7A

2.66e-0431813GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

PHF2 KDM5B KDM7A

2.93e-0432813GO:0140457
GeneOntologyMolecularFunctiondioxygenase activity

PHF2 KDM5B KDM7A PLOD1

6.80e-0498814GO:0051213
GeneOntologyMolecularFunctiondemethylase activity

PHF2 KDM5B KDM7A

7.55e-0444813GO:0032451
GeneOntologyMolecularFunctionproteoglycan binding

SLIT2 LRP1 AGRN

1.16e-0351813GO:0043394
GeneOntologyMolecularFunctionhistone H3K9 demethylase activity

PHF2 KDM7A

1.43e-0314812GO:0032454
GeneOntologyMolecularFunctionhistone modifying activity

PHF2 KDM5B SIRT2 KMT2A KDM7A

2.40e-03229815GO:0140993
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

COL4A2 SLIT2 KDM5B CAD FBN1 DLL4 LRP1 KCP KMT2A DSG4 IL17RD NOS1 TNXB LRP8 SORL1

8.07e-078508015GO:0071363
GeneOntologyBiologicalProcessresponse to growth factor

COL4A2 SLIT2 KDM5B CAD FBN1 DLL4 LRP1 KCP KMT2A DSG4 IL17RD NOS1 TNXB LRP8 SORL1

1.30e-068838015GO:0070848
GeneOntologyBiologicalProcessnegative regulation of Notch signaling pathway

DLL4 DLK1 HERC2 NOTCH4

3.59e-0548804GO:0045746
GeneOntologyBiologicalProcessheterochromatin formation

PHF2 SIRT2 WDHD1 MOV10L1 KMT2A SPOCD1

4.12e-05163806GO:0031507
GeneOntologyBiologicalProcessregulation of Notch signaling pathway

DLL4 DLK1 HERC2 RECK NOTCH4

8.16e-05114805GO:0008593
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

SLIT2 SIRT2 FBN1 CDK12 LRP4 DLK1 IL17RD ZNF418 BBS12 NOTCH3 NOTCH4 SORL1

1.33e-048758012GO:0045596
GeneOntologyBiologicalProcessnegative regulation of gene expression, epigenetic

PHF2 SIRT2 WDHD1 MOV10L1 KMT2A SPOCD1

1.38e-04203806GO:0045814
GeneOntologyBiologicalProcessregulation of nervous system development

SLIT2 SIRT2 DLL4 LRP1 LRP4 SYNDIG1 NOS1 AGRN LRP8 SORL1

1.48e-046258010GO:0051960
GeneOntologyBiologicalProcessnegative regulation of fat cell differentiation

SIRT2 FBN1 DLK1 BBS12

1.58e-0470804GO:0045599
GeneOntologyBiologicalProcessNotch signaling pathway

DLL4 DLK1 HERC2 RECK NOTCH3 NOTCH4

1.67e-04210806GO:0007219
GeneOntologyBiologicalProcessnegative regulation of heterochromatin formation

PHF2 KMT2A

2.21e-046802GO:0031452
GeneOntologyCellularComponentextracellular matrix

COL4A2 SLIT2 FBN1 VWF MEGF6 LAMA2 TECTA PLOD1 SSPOP AGRN TNXB FBN3 LGALS3BP

1.34e-066568113GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

COL4A2 SLIT2 FBN1 VWF MEGF6 LAMA2 TECTA PLOD1 SSPOP AGRN TNXB FBN3 LGALS3BP

1.39e-066588113GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

COL4A2 SLIT2 FBN1 VWF MEGF6 LAMA2 PLOD1 SSPOP AGRN TNXB LGALS3BP

6.12e-065308111GO:0062023
GeneOntologyCellularComponentcell surface

SLIT2 ITGBL1 VWF ENPP3 LRP1 LRP4 ASTN1 SCART1 DLK1 TNFRSF10C AGRN NOTCH3 NOTCH4 LRP8 SORL1

2.08e-0511118115GO:0009986
GeneOntologyCellularComponentcell body

PCSK5 SLIT2 SIRT2 CAD KCNC3 P2RX6 LRP1 SYN1 LRP4 ASTN1 SYNDIG1 LRP8 SORL1

5.52e-059298113GO:0044297
GeneOntologyCellularComponentsomatodendritic compartment

PCSK5 SLIT2 SIRT2 CAD KCNC3 P2RX6 LRP1 LAMA2 SYN1 LRP4 ASTN1 SYNDIG1 NOS1 LRP8 SORL1

6.57e-0512288115GO:0036477
GeneOntologyCellularComponentneuronal cell body

PCSK5 SLIT2 SIRT2 CAD KCNC3 P2RX6 LRP1 LRP4 ASTN1 LRP8 SORL1

3.65e-048358111GO:0043025
GeneOntologyCellularComponentdendrite

PCSK5 SLIT2 KCNC3 P2RX6 LRP1 LAMA2 SYN1 LRP4 SYNDIG1 NOS1 LRP8

4.59e-048588111GO:0030425
GeneOntologyCellularComponentdendritic tree

PCSK5 SLIT2 KCNC3 P2RX6 LRP1 LAMA2 SYN1 LRP4 SYNDIG1 NOS1 LRP8

4.68e-048608111GO:0097447
GeneOntologyCellularComponentpostsynaptic specialization

P2RX6 LRP1 SYN1 LRP4 SYNDIG1 GSG1L NOS1 LRP8

7.34e-04503818GO:0099572
GeneOntologyCellularComponentpostsynaptic specialization membrane

P2RX6 LRP1 SYNDIG1 GSG1L LRP8

1.11e-03201815GO:0099634
GeneOntologyCellularComponentmicrofibril

FBN1 FBN3

1.13e-0313812GO:0001527
GeneOntologyCellularComponentbasement membrane

COL4A2 FBN1 LAMA2 AGRN

1.30e-03122814GO:0005604
GeneOntologyCellularComponentprotein complex involved in cell adhesion

ITGBL1 LAMA2 TNXB

1.56e-0359813GO:0098636
GeneOntologyCellularComponentpostsynaptic density

LRP1 SYN1 LRP4 SYNDIG1 GSG1L NOS1 LRP8

1.83e-03451817GO:0014069
GeneOntologyCellularComponentGolgi membrane

PCSK5 SCAP SYNDIG1 IL17RD ZDHHC3 NOTCH3 NOTCH4 PLCE1 SORL1

1.87e-03721819GO:0000139
GeneOntologyCellularComponentprotein complex involved in cell-matrix adhesion

LAMA2 TNXB

1.94e-0317812GO:0098637
GeneOntologyCellularComponentdendritic spine

KCNC3 P2RX6 LAMA2 SYNDIG1 NOS1

2.50e-03242815GO:0043197
GeneOntologyCellularComponentasymmetric synapse

LRP1 SYN1 LRP4 SYNDIG1 GSG1L NOS1 LRP8

2.51e-03477817GO:0032279
GeneOntologyCellularComponentneuron spine

KCNC3 P2RX6 LAMA2 SYNDIG1 NOS1

2.73e-03247815GO:0044309
GeneOntologyCellularComponentpostsynaptic density membrane

LRP1 SYNDIG1 GSG1L LRP8

3.25e-03157814GO:0098839
GeneOntologyCellularComponentexternal side of plasma membrane

VWF ENPP3 LRP1 ASTN1 SCART1 DLK1 TNFRSF10C

3.99e-03519817GO:0009897
GeneOntologyCellularComponentneuron to neuron synapse

LRP1 SYN1 LRP4 SYNDIG1 GSG1L NOS1 LRP8

4.16e-03523817GO:0098984
DomainEGF

PCSK5 SLIT2 ITGBL1 FBN1 MEGF6 DLL4 LRP1 LAMA2 LRP4 CRELD2 ASTN1 DLK1 TECTA LRP1B AGRN TNXB FBN3 NOTCH3 NOTCH4 LRP8 SORL1

1.08e-222357721SM00181
DomainEGF-like_dom

PCSK5 SLIT2 ITGBL1 FBN1 MEGF6 DLL4 LRP1 LAMA2 LRP4 CRELD2 ASTN1 DLK1 TECTA LRP1B AGRN TNXB FBN3 NOTCH3 NOTCH4 LRP8 SORL1

3.69e-222497721IPR000742
DomainEGF_2

SLIT2 ITGBL1 FBN1 MEGF6 DLL4 LRP1 LAMA2 LRP4 CRELD2 ASTN1 DLK1 LRP1B SSPOP AGRN TNXB FBN3 NOTCH3 NOTCH4 LRP8 SORL1

3.80e-202657720PS01186
DomainEGF_1

SLIT2 ITGBL1 FBN1 MEGF6 DLL4 LRP1 LAMA2 LRP4 CRELD2 ASTN1 DLK1 LRP1B SSPOP AGRN TNXB FBN3 NOTCH3 NOTCH4 LRP8

4.74e-192557719PS00022
DomainEGF_3

SLIT2 FBN1 MEGF6 DLL4 LRP1 LRP4 CRELD2 ASTN1 DLK1 LRP1B SSPOP AGRN TNXB FBN3 NOTCH3 NOTCH4 LRP8 SORL1

2.75e-182357718PS50026
DomainEGF-like_CS

SLIT2 FBN1 MEGF6 DLL4 LRP1 LAMA2 LRP4 CRELD2 ASTN1 DLK1 LRP1B AGRN TNXB FBN3 NOTCH3 NOTCH4 LRP8 SORL1

1.80e-172617718IPR013032
DomainEGF_CA

SLIT2 FBN1 MEGF6 DLL4 LRP1 LRP4 CRELD2 DLK1 LRP1B AGRN FBN3 NOTCH3 NOTCH4 LRP8

7.12e-171227714SM00179
DomainEGF-like_Ca-bd_dom

SLIT2 FBN1 MEGF6 DLL4 LRP1 LRP4 CRELD2 DLK1 LRP1B AGRN FBN3 NOTCH3 NOTCH4 LRP8

8.99e-171247714IPR001881
DomainEGF

SLIT2 MEGF6 DLL4 LRP1 LRP4 DLK1 TECTA LRP1B AGRN TNXB FBN3 NOTCH3 NOTCH4 LRP8

1.13e-161267714PF00008
DomainASX_HYDROXYL

SLIT2 FBN1 MEGF6 DLL4 LRP1 LRP4 CRELD2 DLK1 LRP1B FBN3 NOTCH3 NOTCH4 LRP8

1.84e-161007713PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

SLIT2 FBN1 MEGF6 DLL4 LRP1 LRP4 CRELD2 DLK1 LRP1B FBN3 NOTCH3 NOTCH4 LRP8

4.04e-161067713IPR000152
DomainGrowth_fac_rcpt_

PCSK5 FBN1 MEGF6 DLL4 LRP1 LRP4 CRELD2 LRP1B TNXB FBN3 NOTCH3 NOTCH4 LRP8

6.73e-141567713IPR009030
DomainEGF_Ca-bd_CS

SLIT2 FBN1 MEGF6 LRP1 LRP4 CRELD2 LRP1B FBN3 NOTCH3 NOTCH4 LRP8

2.09e-13977711IPR018097
DomainEGF_CA

SLIT2 FBN1 MEGF6 LRP1 LRP4 CRELD2 LRP1B FBN3 NOTCH3 NOTCH4 LRP8

2.63e-13997711PS01187
DomainEGF_CA

FBN1 MEGF6 LRP1 LRP4 CRELD2 LRP1B FBN3 NOTCH3 NOTCH4 LRP8

2.13e-12867710PF07645
DomainLDLR_class-A_CS

LRP10 LRP1 LRP4 LRP1B SSPOP LRP8 SORL1

2.56e-1040777IPR023415
DomainLdl_recept_a

LRP10 LRP1 LRP4 LRP1B SSPOP LRP8 SORL1

6.13e-1045777PF00057
Domain-

LRP10 LRP1 LRP4 LRP1B SSPOP LRP8 SORL1

7.21e-10467774.10.400.10
DomainLDLRA_1

LRP10 LRP1 LRP4 LRP1B SSPOP LRP8 SORL1

9.85e-1048777PS01209
DomainLDLRA_2

LRP10 LRP1 LRP4 LRP1B SSPOP LRP8 SORL1

1.15e-0949777PS50068
DomainLDrepeatLR_classA_rpt

LRP10 LRP1 LRP4 LRP1B SSPOP LRP8 SORL1

1.15e-0949777IPR002172
DomainLDLa

LRP10 LRP1 LRP4 LRP1B SSPOP LRP8 SORL1

1.15e-0949777SM00192
DomainLdl_recept_b

LRP1 LRP4 LRP1B LRP8 SORL1

2.03e-0914775PF00058
DomainLDLRB

LRP1 LRP4 LRP1B LRP8 SORL1

2.03e-0914775PS51120
DomainLY

LRP1 LRP4 LRP1B LRP8 SORL1

3.04e-0915775SM00135
DomainLDLR_classB_rpt

LRP1 LRP4 LRP1B LRP8 SORL1

3.04e-0915775IPR000033
DomainEGF_extracell

ITGBL1 MEGF6 DLL4 DLK1 LRP1B TNXB NOTCH3

4.97e-0960777IPR013111
DomainEGF_2

ITGBL1 MEGF6 DLL4 DLK1 LRP1B TNXB NOTCH3

4.97e-0960777PF07974
DomaincEGF

FBN1 LRP1 LRP4 LRP1B FBN3

6.42e-0826775IPR026823
DomaincEGF

FBN1 LRP1 LRP4 LRP1B FBN3

6.42e-0826775PF12662
DomainhEGF

SLIT2 MEGF6 FBN3 NOTCH3 NOTCH4

9.53e-0828775PF12661
DomainUnchr_dom_Cys-rich

VWF KCP TECTA SSPOP

1.86e-0713774IPR014853
DomainC8

VWF KCP TECTA SSPOP

1.86e-0713774SM00832
DomainTIL_dom

VWF KCP TECTA SSPOP

2.59e-0714774IPR002919
DomainVWD

VWF KCP TECTA SSPOP

4.68e-0716774SM00216
DomainVWF_type-D

VWF KCP TECTA SSPOP

4.68e-0716774IPR001846
DomainVWFD

VWF KCP TECTA SSPOP

4.68e-0716774PS51233
DomainVWD

VWF KCP TECTA SSPOP

4.68e-0716774PF00094
Domain-

LRP1 LRP4 LRP1B LRP8 SORL1

5.39e-07397752.120.10.30
DomainVWC_out

VWF KCP TECTA SSPOP

9.87e-0719774SM00215
Domain6-blade_b-propeller_TolB-like

LRP1 LRP4 LRP1B LRP8 SORL1

1.25e-0646775IPR011042
DomainLaminin_G_1

SLIT2 LAMA2 AGRN

1.09e-0511773PF00054
DomainTIL

VWF TECTA SSPOP

1.44e-0512773PF01826
DomainC8

VWF TECTA SSPOP

1.44e-0512773PF08742
DomainDUF5050

LRP1 LRP1B

1.68e-052772IPR032485
DomainDUF5050

LRP1 LRP1B

1.68e-052772PF16472
DomainVWC

VWF KCP TECTA SSPOP

1.77e-0538774SM00214
DomainVWFC_2

VWF KCP TECTA SSPOP

1.77e-0538774PS50184
DomainLaminin_EGF

MEGF6 LAMA2 CRELD2 AGRN

1.77e-0538774IPR002049
DomainVWF_dom

VWF KCP TECTA SSPOP

2.65e-0542774IPR001007
DomainFBN

FBN1 FBN3

5.02e-053772IPR011398
DomainCTCK_1

SLIT2 VWF SSPOP

5.26e-0518773PS01185
DomainNotch

NOTCH3 NOTCH4

1.00e-044772IPR008297
DomainNODP

NOTCH3 NOTCH4

1.00e-044772PF07684
DomainNotch_NODP_dom

NOTCH3 NOTCH4

1.00e-044772IPR011656
DomainNotch_NOD_dom

NOTCH3 NOTCH4

1.00e-044772IPR010660
DomainNOD

NOTCH3 NOTCH4

1.00e-044772PF06816
DomainNOD

NOTCH3 NOTCH4

1.00e-044772SM01338
DomainNODP

NOTCH3 NOTCH4

1.00e-044772SM01339
DomainJmjC

PHF2 KDM5B KDM7A

1.28e-0424773PF02373
DomainCys_knot_C

SLIT2 VWF SSPOP

1.45e-0425773IPR006207
DomainCTCK_2

SLIT2 VWF SSPOP

1.45e-0425773PS01225
DomainLNR

NOTCH3 NOTCH4

1.66e-045772PS50258
Domain-

PCSK5 LAMA2 HERC2 SSPOP

2.34e-04737742.60.120.260
DomainPHD

PHF2 KDM5B KMT2A KDM7A

2.60e-0475774PF00628
DomainJMJC

PHF2 KDM5B KDM7A

3.07e-0432773PS51184
DomainJmjC_dom

PHF2 KDM5B KDM7A

3.07e-0432773IPR003347
DomainZnf_PHD-finger

PHF2 KDM5B KMT2A KDM7A

3.17e-0479774IPR019787
DomainJmjC

PHF2 KDM5B KDM7A

3.36e-0433773SM00558
DomainTB

FBN1 FBN3

3.48e-047772PF00683
DomainNotch_dom

NOTCH3 NOTCH4

3.48e-047772IPR000800
DomainNotch

NOTCH3 NOTCH4

3.48e-047772PF00066
DomainNL

NOTCH3 NOTCH4

3.48e-047772SM00004
DomainLaminin_EGF

MEGF6 LAMA2 AGRN

4.01e-0435773PF00053
DomainEGF_Lam

MEGF6 LAMA2 AGRN

4.01e-0435773SM00180
DomainVWFC_1

VWF KCP SSPOP

4.36e-0436773PS01208
Domain-

FBN1 FBN3

4.62e-0487723.90.290.10
DomainPHD

PHF2 KDM5B KMT2A KDM7A

5.00e-0489774SM00249
DomainLAM_G_DOMAIN

SLIT2 LAMA2 AGRN

5.12e-0438773PS50025
DomainZnf_PHD

PHF2 KDM5B KMT2A KDM7A

5.44e-0491774IPR001965
DomainTB

FBN1 FBN3

5.93e-049772PS51364
DomainTB_dom

FBN1 FBN3

5.93e-049772IPR017878
DomainGalactose-bd-like

PCSK5 LAMA2 HERC2 SSPOP

6.15e-0494774IPR008979
DomainZF_PHD_2

PHF2 KDM5B KMT2A KDM7A

6.40e-0495774PS50016
DomainZF_PHD_1

PHF2 KDM5B KMT2A KDM7A

6.66e-0496774PS01359
DomainLamG

SLIT2 LAMA2 AGRN

7.90e-0444773SM00282
DomainFol_N

SLIT2 AGRN

9.01e-0411772IPR003645
DomainFOLN

SLIT2 AGRN

9.01e-0411772SM00274
Domain-

CAD SYN1

1.27e-03137723.40.50.20
DomainPreATP-grasp_dom

CAD SYN1

1.48e-0314772IPR016185
DomainPLipase_C_Pinositol-sp_Y

PLCH1 PLCE1

1.70e-0315772IPR001711
DomainEF-hand_like

PLCH1 PLCE1

1.70e-0315772PF09279
DomainPIPLC_Y_DOMAIN

PLCH1 PLCE1

1.70e-0315772PS50008
DomainPI-PLC_fam

PLCH1 PLCE1

1.70e-0315772IPR001192
DomainPLC_EF-hand-like

PLCH1 PLCE1

1.70e-0315772IPR015359
DomainPI-PLC-Y

PLCH1 PLCE1

1.70e-0315772PF00387
DomainPLCYc

PLCH1 PLCE1

1.70e-0315772SM00149
Domain-

CAD SYN1

1.70e-03157723.30.1490.20
DomainLaminin_G

SLIT2 LAMA2 AGRN

1.77e-0358773IPR001791
DomainEMI

MEGF6 SSPOP

2.19e-0317772PS51041
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

DLL4 DLK1 NOTCH3 NOTCH4

5.52e-0627624M39545
PathwayPID_NOTCH_PATHWAY

DLL4 DLK1 SSPOP NOTCH3 NOTCH4

5.82e-0659625M17
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A2 FBN1 VWF LAMA2 LRP4 PLOD1 AGRN TNXB FBN3

5.99e-06300629M610
PathwayREACTOME_ECM_PROTEOGLYCANS

COL4A2 LAMA2 LRP4 AGRN TNXB

2.03e-0576625M27219
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

DLL4 NOTCH3 NOTCH4

2.25e-0513623M47423
PathwayKEGG_ECM_RECEPTOR_INTERACTION

COL4A2 VWF LAMA2 AGRN TNXB

3.30e-0584625M7098
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP10 LRP1 AGRN LRP8

4.42e-0545624MM15344
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP10 LRP1 AGRN LRP8

5.71e-0548624M27642
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A2 FBN1 VWF MEGF6 PLOD1 AGRN TNXB

1.32e-04258627MM14572
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH3 NOTCH4

1.89e-045622M27411
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH3 NOTCH4

1.89e-045622MM14733
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

LRP10 LRP1 LRP4 LSS LRP1B LGALS3BP LRP8 SORL1

2.50e-04381628M48063
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

PHF2 KDM5B KDM7A

2.73e-0429623MM14934
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH3 NOTCH4

2.82e-046622M27068
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH3 NOTCH4

3.94e-047622MM14734
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

COL4A2 FBN1 VWF AGRN

5.26e-0485624M16441
PathwayWP_NEOVASCULARIZATION_PROCESSES

DLL4 NOTCH3 NOTCH4

5.66e-0437623M39506
PathwayREACTOME_SIGNALING_BY_NOTCH

DLL4 NOTCH3 NOTCH4

6.61e-0439623MM14604
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

COL4A2 DLL4 DLK1 NOTCH3 NOTCH4

6.99e-04161625M39770
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

LRP10 LRP1 AGRN LRP8

7.10e-0492624MM14881
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

LRP10 LRP1 AGRN LRP8

9.70e-04100624M27158
PathwayWP_NOTCH_SIGNALING_WP268

DLL4 NOTCH3 NOTCH4

1.01e-0345623M39571
PathwayREACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL4 NOTCH4

1.02e-0311622M27882
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH3 NOTCH4

1.02e-0311622M47865
PathwayWP_NOTCH_SIGNALING_PATHWAY

DLL4 NOTCH3 NOTCH4

1.07e-0346623MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

DLL4 NOTCH3 NOTCH4

1.14e-0347623M7946
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH3 NOTCH4

1.22e-0312622M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH3 NOTCH4

1.22e-0312622M47533
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

PHF2 KDM5B KDM7A

1.37e-0350623M27232
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH3 NOTCH4

1.44e-0313622M47534
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

LRP10 ENPP3 LRP1 AGRN LRP8

1.76e-03198625M18311
PathwayREACTOME_LAMININ_INTERACTIONS

COL4A2 MEGF6

1.93e-0315622MM14922
PathwayWP_GPR40_PATHWAY

PLCH1 PLCE1

1.93e-0315622M39526
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

DLL4 NOTCH4

2.20e-0316622M47424
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

COL4A2 LAMA2 AGRN

2.21e-0359623M27218
PathwayWP_NOTCH_SIGNALING_WP61

DLL4 NOTCH3 NOTCH4

2.43e-0361623M39540
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

COL4A2 SLIT2 FBN1 VWF MEGF6 LAMA2 CRELD2 SSPOP AGRN TNXB

1.26e-11175821028071719
Pubmed

APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.

LRP1 LRP4 AGRN LRP8

3.58e-09982423986861
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

COL4A2 PCSK5 SLIT2 ITGBL1 FBN1 VWF LAMA2 AGRN LGALS3BP

7.68e-0924882924006456
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

PCSK5 GPRASP1 FBN1 VWF MEGF6 LRP1 AGRN

1.33e-0811882721078624
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

COL4A2 FBN1 SCAP LRP10 MBOAT7 LRP1 LRP4 CRELD2 PLOD1 LRP1B AGRN NOTCH3 LGALS3BP DMXL1 LRP8 SORL1

1.81e-081201821635696571
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

COL4A2 FBN1 VWF LAMA2 AGRN TNXB LGALS3BP

5.81e-0814682727068509
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

DLL4 DLK1 NOTCH3 NOTCH4

6.67e-081782415821257
Pubmed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.

COL4A2 FBN1 LAMA2 AGRN TNXB LGALS3BP

1.19e-079782627559042
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 LRP4 SORL1

1.26e-07582319047013
Pubmed

Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

DLL4 NOTCH3 NOTCH4

1.26e-07582321726900
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

DLL4 NOTCH3 NOTCH4

1.26e-07582323675950
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1 LRP4 LRP1B LRP8

1.67e-072182421337463
Pubmed

A study on Notch signaling in human breast cancer.

DLL4 NOTCH3 NOTCH4

2.51e-07682317822320
Pubmed

The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses.

SYN1 LRP4 AGRN

4.39e-07782325368159
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

COL4A2 LAMA2 SSPOP AGRN TNXB

4.40e-076482522261194
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

SLIT2 ITGBL1 SIRT2 FBN1 VWF MEGF6 MBOAT7 CRELD2 AGRN NOTCH3

8.19e-07560821021653829
Pubmed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

COL4A2 FBN1 VWF LAMA2 AGRN TNXB

8.41e-0713582628675934
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 VWF MEGF6

1.05e-06982312122015
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

DLL4 NOTCH3 NOTCH4

1.05e-06982316245338
Pubmed

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

LRP1 LRP8 SORL1

1.05e-06982320005821
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

DLL4 NOTCH3 NOTCH4

1.50e-061082323665443
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP4 LRP1B

2.06e-061182324639464
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

LRP10 LRP1 PLOD1 AGRN LGALS3BP SORL1

2.61e-0616482632409323
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

DLL4 NOTCH3 NOTCH4

2.74e-061282315465494
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

COL4A2 FBN1 VWF LAMA2 PLOD1 AGRN

2.90e-0616782622159717
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

DLL4 NOTCH3 NOTCH4

3.55e-061382311578869
Pubmed

Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.

VWF NOTCH3 NOTCH4

3.55e-061382320558824
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

COL4A2 FBN1 AGRN TNXB LGALS3BP

4.27e-0610182520551380
Pubmed

Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.

DLK1 NOTCH3 NOTCH4

4.51e-061482328192800
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

DLL4 NOTCH3 NOTCH4

4.51e-061482314757642
Pubmed

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.

VWF DLL4 NOTCH3 NOTCH4

5.16e-064882428924218
Pubmed

Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation.

DLL4 DLK1

5.49e-06282225687759
Pubmed

Striking differences of LDL receptor-related protein 1B expression in mouse and human.

LRP1 LRP1B

5.49e-06282215963947
Pubmed

Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2.

COL4A2 NOTCH3

5.49e-06282225169943
Pubmed

Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice.

NOTCH3 NOTCH4

5.49e-06282233665264
Pubmed

Loss of apolipoprotein E receptor LR11 in Alzheimer disease.

LRP8 SORL1

5.49e-06282215313836
Pubmed

Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.

LRP1 LRP8

5.49e-06282212871934
Pubmed

Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma.

NOTCH3 NOTCH4

5.49e-06282217696940
Pubmed

Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family.

LRP10 LRP4

5.49e-06282220005200
Pubmed

Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma.

PHF2 KDM5B

5.49e-06282222534467
Pubmed

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses.

LRP4 AGRN

5.49e-06282222854782
Pubmed

Association study between the TNXB locus and schizophrenia in a Japanese population.

TNXB NOTCH4

5.49e-06282217192952
Pubmed

Amelioration of laminin-alpha2-deficient congenital muscular dystrophy by somatic gene transfer of miniagrin.

LAMA2 AGRN

5.49e-06282216103356
Pubmed

Exome sequencing identified new mutations in a Marfan syndrome family.

FBN1 LRP1

5.49e-06282224484584
Pubmed

A genetic determinant that specifically regulates the frequency of hematopoietic stem cells.

NOTCH3 NOTCH4

5.49e-06282211777956
Pubmed

Notch signaling in primary endothelial cells.

DLL4 NOTCH4

5.49e-06282212814948
Pubmed

Breast cancer stem cells: something out of notching?

DLL4 NOTCH4

5.49e-06282221045140
Pubmed

Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome.

FBN1 NOTCH3

5.49e-06282232616814
Pubmed

LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and dementia with Lewy bodies.

LRP10 SORL1

5.49e-06282233913039
Pubmed

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.

FBN1 FBN3

5.49e-06282215221638
Pubmed

Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice.

NOTCH3 NOTCH4

5.49e-06282225658374
Pubmed

Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy.

DLL4 NOTCH3

5.49e-06282219208840
Pubmed

Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer.

DLL4 NOTCH3

5.49e-06282236740988
Pubmed

Activity-dependent Notch signalling in the hypothalamic-neurohypophysial system of adult mouse brains.

DLL4 NOTCH3

5.49e-06282224943269
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

PHF2 KDM5B KMT2A KDM7A

5.61e-064982434368113
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

DLL4 NOTCH3 NOTCH4

5.63e-061582312971992
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

DLL4 NOTCH3 NOTCH4

6.92e-061682312617809
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

DLL4 NOTCH3 NOTCH4

6.92e-061682317273555
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

DLL4 NOTCH3 NOTCH4

8.39e-061782318694942
Pubmed

Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking.

DLL4 NOTCH3 NOTCH4

8.39e-061782339315665
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

DLL4 NOTCH3 NOTCH4

1.00e-051882318093989
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

DLL4 NOTCH3 NOTCH4

1.00e-051882315689374
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCSK5 SIRT2 SCAP WIZ MEGF6 CDK12 TMEM94 LRP4 LRRK1 HERC2 IL17RD AGRN

1.07e-051105821235748872
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

SLIT2 DLL4 NOTCH3 NOTCH4

1.18e-055982421421844
Pubmed

Counteractive and cooperative actions of muscle β-catenin and CaV1.1 during early neuromuscular synapse formation.

SLIT2 SYN1 LRP4

1.19e-051982335340430
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

DLL4 NOTCH3 NOTCH4

1.19e-051982316518823
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

COL4A2 CAD ENPP3 LRP1 TUT1 PLOD1 LGALS3BP SORL1 COPS7A

1.45e-0561382922268729
Pubmed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

DLL4 NOTCH3 NOTCH4

1.63e-052182328656980
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM5B KMT2A KDM7A

1.63e-052182327626377
Pubmed

Notch receptor expression in human brain arteriovenous malformations.

NOTCH3 NOTCH4

1.64e-05382225846406
Pubmed

MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters.

LRP4 AGRN

1.64e-05382224244707
Pubmed

Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.

FBN1 RECK

1.64e-05382232730638
Pubmed

Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK).

LRP4 AGRN

1.64e-05382221969364
Pubmed

Recombinant von Willebrand factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease.

VWF LRP1

1.64e-05382211992244
Pubmed

Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.

NOTCH3 NOTCH4

1.64e-05382215645445
Pubmed

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

LRP1 SORL1

1.64e-05382228799085
Pubmed

The vascular delta-like ligand-4 (DLL4)-Notch4 signaling correlates with angiogenesis in primary glioblastoma: an immunohistochemical study.

DLL4 NOTCH4

1.64e-05382226472724
Pubmed

Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5.

PCSK5 LGALS3BP

1.64e-05382221094132
Pubmed

Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.

LRP1 LRP8

1.64e-05382224251389
Pubmed

Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.

LRP1 NOTCH3

1.64e-05382220472562
Pubmed

DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells.

DLL4 NOTCH3

1.64e-05382237971882
Pubmed

Shear stress-independent binding of von Willebrand factor-type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance.

VWF LRP1

1.64e-05382225728415
Pubmed

Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues.

DLL4 NOTCH4

1.64e-05382222066479
Pubmed

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

LRP1 PLCE1

1.64e-05382227322543
Pubmed

The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions.

DLL4 NOTCH4

1.64e-05382216951162
Pubmed

Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.

LRP1 LRP8

1.64e-05382212807892
Pubmed

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

DLL4 NOTCH3 NOTCH4

2.16e-052382314701881
Pubmed

Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.

DLL4 NOTCH3 NOTCH4

2.16e-052382336239412
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

FBN1 LRP1 LAMA2 SSPOP

2.47e-057182433541421
Pubmed

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.

DLK1 NOTCH3 NOTCH4

3.16e-052682325446530
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

DLL4 NOTCH3 NOTCH4

3.16e-052682319369401
Pubmed

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

COL4A2 FBN1 VWF LAMA2 TNXB

3.20e-0515382525037231
Pubmed

A DNA pooling-based case-control study of myopia candidate genes COL11A1, COL18A1, FBN1, and PLOD1 in a Chinese population.

FBN1 PLOD1

3.28e-05482221527992
Pubmed

Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

PLCH1 PLCE1

3.28e-05482221041529
Pubmed

The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway.

LRP10 LRP4

3.28e-05482220093106
Pubmed

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

NOTCH3 NOTCH4

3.28e-05482224145721
Pubmed

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.

NOTCH3 NOTCH4

3.28e-05482220069356
Pubmed

Expression and clinical significance of Notch receptors in human renal cell carcinoma.

NOTCH3 NOTCH4

3.28e-05482219404845
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH3 NOTCH4

3.28e-05482228669409
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN3

3.28e-05482225034023
InteractionZFP41 interactions

FBN1 LRP1 LRP4 CRELD2 LRP1B AGRN NOTCH3 SORL1

5.49e-1157798int:ZFP41
InteractionNTN5 interactions

FBN1 LRP4 LRP1B NOTCH3 SORL1

3.26e-0824795int:NTN5
InteractionIGFL3 interactions

PCSK5 LRP4 LRP1B AGRN NOTCH3 SORL1

4.86e-0775796int:IGFL3
InteractionZNF224 interactions

LRP4 LRP1B NOTCH3 SORL1

1.01e-0620794int:ZNF224
InteractionFEZF1 interactions

LRP4 HERC2 LRP1B SORL1

4.17e-0628794int:FEZF1
InteractionCACNA1A interactions

PCSK5 KDM5B VWF MEGF6 LRP1 AGRN

8.83e-06123796int:CACNA1A
InteractionHOXA1 interactions

PCSK5 SLIT2 KDM5B FBN1 VWF MEGF6 CRELD2 AGRN NOTCH3

1.05e-05356799int:HOXA1
InteractionTMEM94 interactions

CDK12 TMEM94 DLK1 TNFRSF10C

1.17e-0536794int:TMEM94
InteractionZNF563 interactions

LRP4 LRP1B SORL1

1.24e-0512793int:ZNF563
InteractionIGSF5 interactions

LRP4 CRELD2 NOTCH3

2.05e-0514793int:IGSF5
InteractionZNF408 interactions

FBN1 CHAF1A LRP4 LRP1B NOTCH3 SORL1

2.26e-05145796int:ZNF408
InteractionDEFB123 interactions

LRP4 LRP1B SORL1

3.13e-0516793int:DEFB123
InteractionFBXO2 interactions

PCSK5 SLIT2 FBN1 SCAP LRP10 LRP1B AGRN NOTCH3 SORL1

3.26e-05411799int:FBXO2
InteractionFBXL5 interactions

CIAO1 EVPL HERC2 COPS7A

3.43e-0547794int:FBXL5
InteractionMFAP5 interactions

FBN1 VWF MEGF6 NOTCH3

5.13e-0552794int:MFAP5
InteractionATXN7 interactions

GPRASP1 FBN1 VWF MEGF6 AGRN

6.92e-05109795int:ATXN7
InteractionNOTCH4 interactions

DLL4 NOTCH3 NOTCH4

7.33e-0521793int:NOTCH4
InteractionANKRD36B interactions

LRP1 LRP4 LRP1B SORL1

9.03e-0560794int:ANKRD36B
InteractionTMEM121B interactions

KDM5B TMEM121B

9.06e-054792int:TMEM121B
InteractionFBXO6 interactions

COL4A2 CAD LRP10 ENPP3 LRP1 TUT1 PLOD1 AGRN LGALS3BP SORL1 COPS7A

1.07e-047177911int:FBXO6
InteractionCOL5A1 interactions

COL4A2 FBN1 PLOD1 LGALS3BP

1.23e-0465794int:COL5A1
InteractionHSP90B1 interactions

CAD VWF CIAO1 LRP1 CRELD2 KMT2A HERC2 PLCH1 LRP1B AGRN

2.21e-046507910int:HSP90B1
InteractionDLL4 interactions

DLL4 NOTCH4

2.25e-046792int:DLL4
InteractionCPLX3 interactions

CIAO1 DSG4 LRRK1

2.41e-0431793int:CPLX3
GeneFamilyLow density lipoprotein receptors

LRP10 LRP1 LRP4 LRP1B LRP8

2.73e-1013555634
GeneFamilyPHD finger proteins|Lysine demethylases

PHF2 KDM5B KDM7A

5.15e-0524553485
GeneFamilyPHD finger proteins

PHF2 KDM5B KMT2A KDM7A

1.61e-049055488
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCH1 PLCE1

1.50e-0319552832
CoexpressionNABA_ECM_GLYCOPROTEINS

SLIT2 FBN1 VWF LAMA2 KCP CRELD2 TECTA SSPOP AGRN TNXB FBN3

2.72e-111968211M3008
CoexpressionNABA_CORE_MATRISOME

COL4A2 SLIT2 FBN1 VWF LAMA2 KCP CRELD2 TECTA SSPOP AGRN TNXB FBN3

6.04e-112758212M5884
CoexpressionNABA_ECM_GLYCOPROTEINS

SLIT2 FBN1 VWF LAMA2 KCP CRELD2 TECTA SSPOP AGRN TNXB

4.52e-101918210MM17059
CoexpressionNABA_CORE_MATRISOME

COL4A2 SLIT2 FBN1 VWF LAMA2 KCP CRELD2 TECTA SSPOP AGRN TNXB

8.29e-102708211MM17057
CoexpressionNABA_MATRISOME

COL4A2 PCSK5 SLIT2 FBN1 VWF MEGF6 LAMA2 KCP CRELD2 TECTA PLOD1 SSPOP AGRN TNXB FBN3

6.00e-0710268215M5889
CoexpressionLEE_BMP2_TARGETS_UP

VWF LRP10 ENPP3 LRP1 LAMA2 KDM7A LRRK1 IL17RD PLOD1 AGRN TNXB RECK NOTCH3

8.74e-077808213M2324
CoexpressionLEE_BMP2_TARGETS_UP

VWF LRP10 ENPP3 LRP1 LAMA2 KDM7A LRRK1 IL17RD PLOD1 AGRN TNXB RECK NOTCH3

1.24e-068058213MM1067
CoexpressionNABA_MATRISOME

COL4A2 PCSK5 SLIT2 FBN1 VWF MEGF6 LAMA2 KCP CRELD2 TECTA PLOD1 SSPOP AGRN TNXB

2.72e-0610088214MM17056
CoexpressionZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE

GPRASP1 CHAF1A TUT1 AGRN LGALS3BP

4.11e-0676825M1685
CoexpressionZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE

GPRASP1 CHAF1A TUT1 AGRN LGALS3BP

7.56e-0686825MM1209
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL4 NOTCH3 NOTCH4

1.60e-0516823MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL4 NOTCH3 NOTCH4

1.60e-0516823M2207
CoexpressionBOQUEST_STEM_CELL_UP

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 LRP1B RECK

1.80e-05261827M1834
CoexpressionFAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_ENDOTHELIAL

COL4A2 VWF LAMA2 PLOD1 AGRN NOTCH3 NOTCH4 PLCE1

1.90e-05365828M39018
CoexpressionHEVNER_CORTEX_VASCULAR_ENDOTHELIAL_CELLS

VWF DLL4 NOTCH4

2.76e-0519823MM420
CoexpressionGSE31082_DP_VS_CD8_SP_THYMOCYTE_DN

CAD TMEM121B ZNF418 AGRN RECK SORL1

3.96e-05200826M5068
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

COL4A2 SLIT2 FBN1 LRP1 LAMA2 PLOD1

3.96e-05200826M5930
CoexpressionFAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_2

COL4A2 LAMA2 PLOD1 AGRN NOTCH3 LGALS3BP PLCE1

4.66e-05303827M39040
CoexpressionDELYS_THYROID_CANCER_DN

LAMA2 SYNDIG1 PLCH1 LRP1B SSPOP TNXB

9.22e-05233826M13273
CoexpressionCARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_UP

COL4A2 PCSK5 KDM5B WDHD1 DLL4 TMEM94 KCP LRP4 DLK1 NOTCH3 LRP8

1.02e-048918211M45033
CoexpressionPEREZ_TP63_TARGETS

PCSK5 SLIT2 MEGF6 EVPL KDM7A TNFRSF10C NOTCH3

1.28e-04356827M10761
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP

COL4A2 DLL4 SYN1 DLK1 NOTCH4

1.62e-04163825M12112
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HPERIC

COL4A2 FBN1 LRP1 LAMA2 KCP PLOD1 AGRN NOTCH3 LGALS3BP PLCE1

1.86e-047958210M39050
CoexpressionDEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN

COL4A2 CAD LRP4 AGRN NOTCH3 SORL1

2.31e-04276826M3063
CoexpressionMULLIGHAN_MLL_SIGNATURE_2_DN

KDM5B KMT2A AGRN LGALS3BP DMXL1 SORL1

2.45e-04279826M16867
CoexpressionNABA_BASEMENT_MEMBRANES

COL4A2 LAMA2 AGRN

2.68e-0440823M5887
CoexpressionAtlasStromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 DLK1 PLOD1 TNXB RECK

3.51e-05437799GSM777046_500
CoexpressionAtlasStromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3

COL4A2 SLIT2 FBN1 ENPP3 LRP1 LAMA2 PLOD1 TNXB RECK

4.04e-05445799GSM777043_500
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

COL4A2 PCSK5 SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

2.10e-091878284ea486991f66c29728d127171a07b81404ec0b78
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

COL4A2 PCSK5 SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

2.92e-09195828a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOV10L1 LAMA2 KCP ASTN1 KLF18 TECTA LRP1B

1.92e-08160827c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOV10L1 LAMA2 KCP ASTN1 KLF18 TECTA LRP1B

1.92e-0816082725c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

2.68e-081688274b2d29a7843bf45922038c093ca7ec0600756adc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

3.03e-081718275d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TECTA TNXB

3.15e-08172827e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 LRP1B TNXB

3.69e-081768272e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 LRP1B TNXB

3.69e-08176827f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

COL4A2 SLIT2 FBN1 LAMA2 SYNDIG1 NOTCH3 PLCE1

5.39e-08186827cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 KCP TNXB RECK

6.70e-08192827671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 ITGBL1 FBN1 LRP1 LAMA2 PLOD1 TNXB

6.70e-08192827beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

PCSK5 SLIT2 FBN1 VWF LRP1 LAMA2 TNXB

6.70e-0819282760b1312e84f6d6448365a952469c506c00b5fe93
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 KCP TNXB RECK

6.70e-08192827840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCellfacs-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 ENPP3 LRP1 LAMA2 TNXB RECK

6.94e-08193827d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCellLA|World / Chamber and Cluster_Paper

PCSK5 SLIT2 ITGBL1 FBN1 LRP1 LRP1B TNXB

6.94e-08193827d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

COL4A2 PCSK5 SLIT2 FBN1 LRP1 LAMA2 TNXB

7.19e-08194827234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

7.45e-08195827f54bc4454270ff06e85596f98199372b50d0179f
ToppCell(3)_Chondrocytes-(30)_Chondro|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis

COL4A2 ITGBL1 MEGF6 LAMA2 LRRK1 RECK SORL1

7.45e-08195827f5597d3ed37770c6fa2b339f98a80ac7ecd4f9ff
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 ITGBL1 FBN1 LRP1 LAMA2 TNXB NOTCH3

7.71e-08196827fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 ITGBL1 FBN1 LRP1 LAMA2 TNXB NOTCH3

7.71e-08196827802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 ENPP3 LRP1 LAMA2 RECK PLCE1

7.71e-08196827b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 ENPP3 LRP1 LAMA2 RECK PLCE1

7.71e-08196827787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

PCSK5 SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

8.56e-08199827f19c683f38bca3bfee40396f27423441051dec67
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A2 SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

8.85e-08200827389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

THNSL1 VWF DLL4 MOV10L1 IL17RD NOS1 NOTCH4

8.85e-08200827a8b59e6fe04271fef61db911a286b5c48438bb84
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A2 SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

8.85e-08200827b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte|Control_saline / Treatment groups by lineage, cell group, cell type

COL4A2 SLIT2 LRP1 LAMA2 KCP NOTCH3 PLCE1

8.85e-08200827cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCellTracheal-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A2 PCSK5 ITGBL1 FBN1 LRP1 LAMA2 TNXB

8.85e-08200827920e6036c0a9c0089d0d898673daf9dd9d7279fc
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A2 SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

8.85e-082008270c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

COL4A2 SLIT2 LRP1 LAMA2 KCP NOTCH3 PLCE1

8.85e-08200827bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 SYNDIG1 TNXB

8.85e-0820082758b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

COL4A2 PHF2 GSG1L TECTA SPOCD1 LRP1B

5.75e-071638261e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 TNXB RECK

7.10e-07169826bb43abad2c049b7f4d307737347290e01b3339a3
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 TNXB RECK

7.10e-071698265f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 TNXB RECK

7.10e-071698268bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

8.71e-07175826795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

SLIT2 ITGBL1 FBN1 LAMA2 SYNDIG1 TNXB

9.00e-07176826510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCellEndothelial-A-HP_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A2 VWF SYNDIG1 NOS1 TNXB NOTCH4

1.03e-061808264c3376169770ee9f9283daae44c17f35e46bfd19
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 SLIT2 ITGBL1 FBN1 LAMA2 SYNDIG1

1.06e-06181826269b39ac65790061d54eab47a8eeb024403f0348
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 SLIT2 ITGBL1 FBN1 LAMA2 SYNDIG1

1.06e-06181826cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 SLIT2 ITGBL1 FBN1 LAMA2 SYNDIG1

1.06e-06181826c8395ae872aa80b3ae1ab7c53e57b3ca15aeb0e2
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL4A2 SLIT2 FBN1 LRP1 LAMA2 TNXB

1.09e-061828263dfa9187e9d2bab1d199079d29209c4648220ada
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ITGBL1 FBN1 LRP1 LAMA2 DLK1 TNXB

1.17e-0618482601257e5c12e38b849fd3d9496c43ded666249ba5
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 FBN1 VWF MEGF6 DLL4 EVPL

1.17e-06184826f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 FBN1 VWF MEGF6 DLL4 EVPL

1.17e-061848268bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 SYNDIG1 TNXB

1.20e-06185826785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 SYNDIG1 TNXB

1.20e-0618582697a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A2 SLIT2 PLCH1 NOS1 LRP8 PLCE1

1.20e-06185826f4ac62009c0ad3346e71b809e17727303c4df153
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 SYNDIG1 TNXB

1.24e-0618682694d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL4A2 LRP1 LAMA2 DLK1 LRP1B TNXB

1.24e-061868267582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBN1 VWF MEGF6 RECK NOTCH4

1.28e-06187826e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 FBN1 MEGF6 LRP1 LAMA2 TNXB

1.32e-06188826ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLIT2 FBN1 LRP1 LAMA2 DLK1 TNXB

1.32e-06188826fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 DLK1 TNXB

1.36e-06189826544d95df910f1b276995624509a7e41b219baca0
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 VWF DLL4 LRRK1 NOS1 NOTCH4

1.36e-06189826c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBN1 LAMA2 DLK1 IL17RD TNXB PLCE1

1.36e-06189826eccf3d49354a67c94f1ed7c15a98a48a5e8e2ed0
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 FBN1 VWF DLL4 LRRK1 NOTCH4

1.36e-06189826b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBN1 LAMA2 DLK1 IL17RD TNXB PLCE1

1.36e-0618982640764f461b8aa1d3a2c5a30590b7fb9307d47d09
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 FBN1 MEGF6 LRP1 LAMA2 TNXB

1.41e-06190826efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 FBN1 VWF DLL4 LRRK1 NOTCH4

1.41e-06190826aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 ENPP3 LRP1 LAMA2 TNXB

1.45e-061918262b73fcd592d16cae8ded5e45c8fbf2d9adc8caad
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBN1 LAMA2 DLK1 IL17RD TNXB PLCE1

1.45e-061918265271198116343c07202649889057e5774d7fdde3
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 LRP1 LAMA2 TNXB NOTCH3

1.45e-061918261efb47743b6834b64cb0f61721ddbe875b1a66ca
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

COL4A2 SLIT2 FBN1 LAMA2 NOTCH3 PLCE1

1.45e-0619182678c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 FBN1 VWF DLL4 LRRK1 NOTCH4

1.45e-061918264b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 ENPP3 LRP1 LAMA2 TNXB

1.49e-06192826a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 ENPP3 LRP1 LAMA2 TNXB

1.49e-06192826eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.49e-06192826c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 ENPP3 LRP1 LAMA2 TNXB

1.49e-06192826011634a24b0c61d9b463fe755502edbc5cd70b7a
ToppCelldroplet-Fat-Mat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBN1 LRP1 LAMA2 TNXB RECK

1.54e-06193826ebd090d7801480b3cee45caac3d30cc991836769
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBN1 LRP1 LAMA2 TNXB RECK

1.54e-0619382622c58032e58730715224d7934968ce92d150b0e8
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.54e-0619382649600db68ed65cafc67bd45a285b364e4f5f88af
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 KCP PLCH1 NOS1 LRP8 PLCE1

1.54e-0619382653bcd50892c379b2a571751f6eb1062436339fe7
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGBL1 FBN1 LRP1 LAMA2 DLK1 TNXB

1.54e-06193826051f61156b0e2e95292b2d8377faf3190b50f264
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBN1 LRP1 LAMA2 TNXB RECK

1.54e-06193826573ad2f848bede1fe20c7b4b352a9242ec294725
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.54e-0619382645b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCellLV-02._Fibroblast_II|LV / Chamber and Cluster_Paper

COL4A2 PCSK5 SLIT2 FBN1 LAMA2 TNXB

1.59e-06194826014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 LRP4 EVPL TNFRSF10C LRP1B NOS1

1.63e-06195826d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 LRP4 EVPL TNFRSF10C LRP1B NOS1

1.63e-0619582619853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.63e-06195826df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.63e-061958264243190ad291d56694e2155954dbaa879c9d3844
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 FBN1 LRP1 LAMA2 TNXB NOTCH3

1.63e-06195826edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.63e-061958261236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 ITGBL1 FBN1 LAMA2 SYNDIG1 TNXB

1.63e-06195826f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 PCSK5 FBN1 LRP1 LAMA2 LRP4

1.68e-061968266bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 PCSK5 FBN1 LRP1 LAMA2 LRP4

1.68e-06196826c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.68e-0619682642e9828222a9663525d571633e8a454c30bfa7f8
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 FBN1 VWF DLL4 NOS1 NOTCH4

1.73e-06197826ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 ITGBL1 FBN1 MOV10L1 LRP1 LAMA2

1.73e-061978260dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK5 SLIT2 FBN1 LRP1 NOTCH3 LGALS3BP

1.73e-061978265afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK5 SLIT2 FBN1 LRP1 NOTCH3 LGALS3BP

1.73e-061978261baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.73e-0619782671786e9432e2d649f5d86f639abb25e7102deb67
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK5 SLIT2 FBN1 LRP1 NOTCH3 LGALS3BP

1.73e-06197826b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLIT2 FBN1 ASTN1 DLK1 TNXB LGALS3BP

1.73e-061978266b6440f1baad5680cf9e13ca3ab72a2c65523d59
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.73e-06197826c747c496ac090309b7f8a3e9d840928f12c83f2f
ToppCelltumor_Lung-Fibroblasts-COL13A1+_matrix_FBs|tumor_Lung / Location, Cell class and cell subclass

SLIT2 ITGBL1 FBN1 LRP1 LAMA2 TNXB

1.79e-061988262d7842f352273b6b823c86eb548b9f4a4cddf0ae
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

COL4A2 P2RX6 LAMA2 DLK1 GSG1L NOTCH3

1.79e-0619882655e583321f60c95898d93cd0d2615c6692db52ec
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

COL4A2 P2RX6 LAMA2 DLK1 GSG1L NOTCH3

1.84e-06199826e19b296d583f8bad3b66ee998a8153634d6fe09e
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PCSK5 FBN1 LRP1 LAMA2 LRP4 TNXB

1.84e-0619982638cfd367ee8c074c11ba54edeb7a001e375e2687
ComputationalECM and collagens.

COL4A2 SLIT2 FBN1 VWF LRP1 PLOD1 NOTCH3

1.23e-04225547MODULE_47
Drugmonatepil

LRP10 LRP1 LRP4 LRP1B SORL1

5.24e-0829805CID000060810
Drugpitavastatin

SCAP LRP10 LRP1 LRP4 DLK1 LRP1B SORL1

1.54e-07114807CID005282451
DrugBendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A

SIRT2 SCAP MBOAT7 CHAF1A EVPL GTF3C5 NOTCH3 SORL1

4.64e-071978083415_DN
Drug25-hydroxycholesterol

SCAP LRP10 LRP1 LRP4 LSS LRP1B SORL1

1.53e-06160807CID000065094
DrugTetracycline hydrochloride [64-75-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A

SLIT2 WIZ MBOAT7 KMT2A LSS TNFRSF10C NOS1

6.49e-061998072243_DN
Drugezetimibe

SCAP LRP10 LRP1 LRP4 LRP1B SORL1

1.33e-05147806CID000150311
Drugreactive blue 2

P2RX6 ENPP3 PLCH1 NOS1 PLCE1

1.39e-0587805CID000656725
DrugEpi Lovastatin

SCAP LRP10 LRP1 LRP4 TNFRSF10C LRP1B LRP8 SORL1

2.65e-05341808CID000003962
DrugAC1Q5S71

VWF DLL4 DLK1 PLCH1 NOS1 PLCE1

3.02e-05170806CID000000501
DrugLY 294002; Up 200; 10uM; PC3; HT_HG-U133A

FBN1 THNSL1 WIZ MEGF6 LRP1 LAMA2

4.99e-051868064463_UP
DrugCalpain inhibitor I

SCAP LRP10 LRP1 LRP4 DLK1 LRP1B SORL1

5.83e-05280807CID000004332
Drughexaconazole

SLIT2 LSS IL17RD LRP8 SORL1

6.30e-05119805ctd:C409722
DrugTolfenamic acid [13710-19-5]; Down 200; 15.2uM; HL60; HG-U133A

CDK12 CIAO1 KMT2A GTF3C5 RECK DMXL1

6.31e-051948061437_DN
DrugCloperastine hydrochloride [14984-68-0]; Down 200; 11uM; MCF7; HT_HG-U133A

WIZ CHAF1A EVPL TUT1 NOTCH3 LGALS3BP

6.49e-051958063408_DN
DrugFelodipine [72509-76-3]; Up 200; 10.4uM; PC3; HT_HG-U133A

KDM5B ASTN1 KDM7A PLCH1 TECTA ELAC1

6.49e-051958066695_UP
DrugOxprenolol hydrochloride [6452-73-9]; Down 200; 13.2uM; MCF7; HT_HG-U133A

PHF2 GPRASP1 WDHD1 TMEM94 CHAF1A NOTCH3

6.49e-051958067225_DN
DrugYohimbine hydrochloride [65-19-0]; Down 200; 10.2uM; MCF7; HT_HG-U133A

SIRT2 KMT2A TUT1 TNFRSF10C NOS1 AGRN

6.67e-051968062755_DN
DrugLobeline alpha (-) hydrochoride [134-63-4]; Up 200; 10.6uM; HL60; HG-U133A

WIZ LAMA2 TUT1 TNFRSF10C ZDHHC3 AGRN

6.67e-051968061770_UP
DrugHydroxyzine dihydrochloride [2192-20-3]; Down 200; 9uM; PC3; HG-U133A

MBOAT7 CHAF1A KMT2A EVPL AGRN LRP8

6.86e-051978061941_DN
DrugMeticrane [1084-65-7]; Up 200; 14.6uM; PC3; HT_HG-U133A

LRP1 KMT2A LSS LRRK1 NOS1 GTF3C5

7.06e-051988067282_UP
Drugepicholesterol

SCAP VWF LRP10 AMACR LRP1 LRP4 LSS LRP1B LRP8 SORL1

7.64e-056368010CID000000304
DrugLopac-P-178

P2RX6 PLCH1 NOS1 PLCE1

9.15e-0567804CID005478935
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN3

2.01e-053772DOID:65 (implicated_via_orthology)
Diseasehemangioblastoma (is_marker_for)

DLL4 NOTCH4

4.02e-054772DOID:5241 (is_marker_for)
Diseasecortical surface area measurement

SLIT2 FBN1 MEGF6 ENPP3 CHAF1A LAMA2 IL17RD GK5 TNXB FBN3 LRP8 PLCE1 COPS7A

4.19e-0513457713EFO_0010736
Diseasespontaneous coronary artery dissection

COL4A2 FBN1 LRP1

7.29e-0531773EFO_0010820
DiseaseHypotrichosis simplex

LSS DSG4

1.40e-047772C1854310
Diseasecortical thickness

COL4A2 SLIT2 FBN1 CHAF1A LRP1 LAMA2 LRP4 KMT2A PLCH1 LRP8 PLCE1

1.43e-0411137711EFO_0004840
Diseasesyndromic X-linked intellectual disability (implicated_via_orthology)

PHF2 KDM7A

1.86e-048772DOID:0060309 (implicated_via_orthology)
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

FBN1 VWF

1.86e-048772DOID:4783 (biomarker_via_orthology)
Diseasehemangiopericytoma (is_marker_for)

DLL4 NOTCH4

2.39e-049772DOID:264 (is_marker_for)
Diseaseaortic aneurysm

FBN1 LRP1

2.98e-0410772EFO_0001666
Diseaseubiquitin-conjugating enzyme E2 G2 measurement

TNXB NOTCH4

2.98e-0410772EFO_0022035
DiseaseSmall cell carcinoma of lung

COL4A2 SLIT2 KMT2A

3.85e-0454773C0149925
DiseaseAlzheimer's disease (is_implicated_in)

LRP1 NOS1 LRP8 SORL1

4.02e-04132774DOID:10652 (is_implicated_in)
Diseaseretinopathy of prematurity (biomarker_via_orthology)

DLL4 NOS1

4.36e-0412772DOID:13025 (biomarker_via_orthology)
Diseasedementia (is_implicated_in)

NOTCH4 LRP8

4.36e-0412772DOID:1307 (is_implicated_in)
DiseaseMalignant neoplasm of breast

VWF DLL4 LAMA2 HERC2 TECTA SPOCD1 PLOD1 NOTCH3 NOTCH4 SORL1

4.70e-0410747710C0006142
DiseaseSchizophrenia

AMACR LRP1 LAMA2 SYN1 KMT2A NOS1 TNXB NOTCH4 LRP8

4.83e-04883779C0036341
DiseaseMigraine Disorders

LRP1 NOTCH3

5.15e-0413772C0149931
Diseasecortisol measurement, response to corticosteroid, response to synacthen

LRP1B NOS1

5.15e-0413772EFO_0005843, EFO_0009175, GO_0031960
DiseaseImpaired cognition

NOTCH3 SORL1

5.99e-0414772C0338656
Diseasetransient cerebral ischemia (implicated_via_orthology)

VWF KMT2A NOS1

6.35e-0464773DOID:224 (implicated_via_orthology)
Diseaseglaucoma

KMT2A HERC2 LRP1B PLCE1

7.18e-04154774MONDO_0005041
DiseaseMyasthenic Syndromes, Congenital, Slow Channel

LRP4 AGRN

7.88e-0416772C0751885
Diseaseendoplasmic reticulum resident protein 29 measurement

TNXB NOTCH4

7.88e-0416772EFO_0020346
Diseasedepressive symptom measurement

PHF2 VWF LRP4 KMT2A NOS1 TNXB

8.74e-04426776EFO_0007006
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

LRP4 AGRN

8.91e-0417772C0751883
Diseasecervical artery dissection

LRP1 PLCE1

8.91e-0417772EFO_1000059
Diseasecolorectal cancer

COL4A2 FBN1 LRP1 HERC2 PLCH1 NOS1 NOTCH4

1.01e-03604777MONDO_0005575
DiseaseX-11470 measurement

TNXB NOTCH4

1.12e-0319772EFO_0021241
DiseaseCongenital Myasthenic Syndromes, Presynaptic

LRP4 AGRN

1.12e-0319772C0751884
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

PCSK5 SLIT2

1.12e-0319772DOID:9562 (implicated_via_orthology)
Diseaserenovascular hypertension (biomarker_via_orthology)

LAMA2 NOS1

1.12e-0319772DOID:1591 (biomarker_via_orthology)
DiseaseFEV/FEC ratio

COL4A2 PCSK5 PHF2 FBN1 MEGF6 LRP1 TUT1 KDM7A TNXB SORL1

1.31e-0312287710EFO_0004713
Diseasedescending aortic diameter

FBN1 LRP1 PLCE1

1.60e-0388773EFO_0021788
Diseasevenous thromboembolism, tissue plasminogen activator measurement

VWF LRP4

1.64e-0323772EFO_0004286, EFO_0004791
Diseaseage-related macular degeneration

HERC2 TNXB NOTCH4

1.65e-0389773EFO_0001365
DiseaseMyasthenic Syndromes, Congenital

LRP4 AGRN

1.79e-0324772C0751882
DiseaseCarcinoma, Pancreatic Ductal

NOTCH3 NOTCH4

1.79e-0324772C0887833
Diseasesystemic scleroderma (is_implicated_in)

FBN1 NOTCH4

1.79e-0324772DOID:418 (is_implicated_in)
Diseasecomplement C4b measurement

TNXB NOTCH4

1.94e-0325772EFO_0008092
DiseaseSquamous cell carcinoma of esophagus

TNXB NOTCH3 PLCE1

1.99e-0395773C0279626
Diseasemyeloperoxidase measurement

TNXB NOTCH4

2.10e-0326772EFO_0005243
Diseasemigraine disorder, pulse pressure measurement

LRP1 PLCE1

2.10e-0326772EFO_0005763, MONDO_0005277
Diseaseintraocular pressure measurement

PCSK5 FBN1 LRP4 KMT2A HERC2 TNXB

2.16e-03509776EFO_0004695
DiseaseHypermetropia

CDK12 LAMA2 AGRN

2.51e-03103773HP_0000540

Protein segments in the cluster

PeptideGeneStartEntry
AIDVWSCGCILGELF

CDK12

916

Q9NYV4
EWCVGCEVVLSGIEE

COPS7A

176

Q9UBW8
AEWCQIFDGTDACVT

AMACR

281

Q9UHK6
TASEWLDLFCDCLGC

GVINP1

2206

Q7Z2Y8
WYSCEEELSGLGEKC

GSG1L

106

Q6UXU4
GGIWDEDSEDGPCVC

AGRN

691

O00468
WKGDAGECRCTEGDE

COL4A2

476

P08572
TCDEGWGGLFCDQDL

DLL4

271

Q9NR61
IGCVWAADRDCAGDD

CHAF1A

686

Q13111
GWVGDGFECHDLDEC

FBN3

1311

Q75N90
CTDGWDGELCDRDVR

DLK1

76

P80370
NEDCVGDGVCVTFWR

BBS12

461

Q6ZW61
FECESTGGSCWVLEQ

DMXL1

1081

Q9Y485
SGTGDVIEDWCRCDS

ASTN1

1001

O14525
SDGWVGLGCCELAIA

RECK

96

O95980
DICKDWFHGSCVGVE

KDM7A

56

Q6ZMT4
LQDFCGCEVALDLWE

IL17RD

381

Q8NFM7
GCEVALDLWEDFSLC

IL17RD

386

Q8NFM7
WVCDGQPDCADGSDE

LRP10

416

Q7Z4F1
HWICDGEDDCGDGLD

LRP1B

2736

Q9NZR2
CEGFEPCKGDWVEAE

MOV10L1

146

Q9BXT6
CEGLFVADVTDFEGW

LGALS3BP

526

Q08380
CSSEGRGEEVVWCLD

LRRK1

1741

Q38SD2
CVCCTEDGEVYTWGD

HERC2

4261

O95714
CSCYEGWVLEPDGES

LRP1

1246

Q07954
GSIGCCSWIVDDLDE

DSG4

816

Q86SJ6
ESSWVLYDGLCLEEC

PCSK5

1391

Q92824
SDAFWLEDCAQVEEG

PDZD9

241

Q8IXQ8
CDWEEVTTSGPCGEE

EVPL

1721

Q92817
TLDCGWIVSDCTAEA

LSS

446

P48449
EECGWDGLDCASEVP

NOTCH3

1491

Q9UM47
YVAWIAAECGCIAAG

MBOAT7

246

Q96N66
REGWECVFCGDECTG

LAMA2

1566

P24043
GVSGLAAIWCCLEEG

FMO6P

11

O60774
EGDEVDWVQCDGSCN

KDM5B

1496

Q9UGL1
AWVGVSCCELAEEDF

NSUN5P1

6

Q3KNT7
WTFETGCTVCDEGLR

PLOD1

261

Q02809
EGDELCGQEEAFRTW

NOS1

921

P29475
KDRGDCCWDFEDTCV

ENPP3

76

O14638
CCSVGAAWGTEECEE

FBN1

981

P35555
VEEENCCFGTIDTWL

GK5

186

Q6ZS86
CDVEGCTWKFARSDE

KLF18

996

A0A0U1RQI7
DDGFQICAESIEDAW

KMT2A

3676

Q03164
NRDCGECEVGWVLDE

CRELD2

211

Q6UXH1
ECEVGWVLDEGACVD

CRELD2

216

Q6UXH1
WVLDEGACVDVDECA

CRELD2

221

Q6UXH1
VWDAIEGVLCCSSEE

SCAP

991

Q12770
WGDIHGDTCECDERD

ITGBL1

261

O95965
ERWKCDGEEECPDGS

LRP8

101

Q14114
WRCDGEKDCEGGADE

LRP8

146

Q14114
ANCWVDEDCPEGEGG

P2RX6

136

O15547
GEDCEADCPEGRWGL

MEGF6

766

O75095
FWDGKEVSEEAGPCC

GPRASP1

911

Q5JY77
WVDTCSEIFGGLDIC

SYN1

356

P17600
WVCDGYRDCADGSDE

SORL1

1436

Q92673
CKDWFHGSCVGVEEE

PHF2

26

O75151
LCDGVWDCPDGADEG

SSPOP

1511

A2VEC9
FLGCRGLEALEGCWD

TMEM121B

506

Q9BXQ6
SWGDGVAADCCETTF

SYNDIG1

101

Q9H7V2
EGEGRIEWCCSVCRE

BMT2

91

Q1RMZ1
QGCRSVELDCWDGDD

PLCE1

1431

Q9P212
DGEEFEGPAGSCEWC

KCP

911

Q6ZWJ8
RDVAWLGECDQGCLA

SIRT2

316

Q8IXJ6
CGECGWAFADPTALE

WIZ

306

O95785
GWGGTSCEENLDDCI

NOTCH4

346

Q99466
EDDWVCCATLEGHES

CIAO1

181

O76071
ESWTTFEEICNGECG

TECTA

876

O75443
DGCGIACAIVTWFLV

ZDHHC3

41

Q9NYG2
GQFWEEGCDVCTCTD

VWF

2441

P04275
ADVVLEACTDFWDGA

TMEM94

706

Q12767
GEGEQVEVDGWDCSF

TUT1

461

Q9H6E5
CGSDGDVRIWEDLDD

WDHD1

31

O75717
SECEEGAGDFLWLDQ

SPOCD1

216

Q6ZMY3
QDGVCICWEGYVSED

TNXB

601

P22105
CTSWDDIQCVEEFGA

TNFRSF10C

141

O14798
ADWCSEGECLAAINS

THNSL1

616

Q8IYQ7
CDDGWDLADAEVVCR

SCART1

811

Q4G0T1
TCHLKEGEEDGFWCI

SLIT2

971

O94813
EGEEDGFWCICADGF

SLIT2

976

O94813
LRCEGECWLFDCGEG

ELAC1

26

Q9H777
LQEGCRCVEVDCWDG

PLCH1

336

Q4KWH8
GSSVEFDWCAVGCIQ

CAD

946

P27708
ISSLGCWCGSEDEEA

ZNF418

41

Q8TF45
DGAENSCTERDGWCL

GTF3C5

426

Q9Y5Q8
ISSLGCWCGVEDEAA

ZNF814

51

B7Z6K7
SGSEDEDWICLAGVD

TMPPE

321

Q6ZT21
LGFWGIDETDVEACC

KCNC3

171

Q14003
EGICLLSGDDAEWDD

LRP4

1811

O75096