Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SP1 ZNF34 ZNF133 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 ESR2 NR4A2 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	6.75e-07	1459	79	20	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SP1 ZNF34 ZNF133 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 ESR2 NR4A2 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 ZFX ZNF574 ZNF646	1.81e-06	1412	79	19	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SP1 ZNF34 ZNF341 ZNF644 ZNF689 ZNF408 ESR2 NR4A2 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	5.77e-06	1244	79	17	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SP1 ZNF34 ZNF341 ZNF644 ZNF689 ZNF408 ESR2 NR4A2 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	7.67e-06	1271	79	17	GO:0000987
GeneOntologyCellularComponent	tumor necrosis factor receptor superfamily complex	TRADD TRAF2	8.42e-05	4	79	2	GO:0002947
Domain	zf-C2H2	SP1 ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 FBXO41 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	4.90e-12	693	78	20	PF00096
Domain	-	SP1 ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	3.14e-11	679	78	19	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	SP1 ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	4.56e-11	694	78	19	IPR013087
Domain	Znf_C2H2-like	SP1 ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 FBXO41 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	5.92e-11	796	78	20	IPR015880
Domain	Znf_C2H2	SP1 ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 FBXO41 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	7.23e-11	805	78	20	IPR007087
Domain	ZnF_C2H2	SP1 ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 FBXO41 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	7.72e-11	808	78	20	SM00355
Domain	ZINC_FINGER_C2H2_2	SP1 ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	2.97e-10	775	78	19	PS50157
Domain	ZINC_FINGER_C2H2_1	SP1 ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF341 ZNF644 ZNF689 ZNF408 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	3.10e-10	777	78	19	PS00028
Domain	Laminin_EGF	NTN4 LAMB4 CELSR3 MEGF11	1.34e-05	35	78	4	PF00053
Domain	EGF_Lam	NTN4 LAMB4 CELSR3 MEGF11	1.34e-05	35	78	4	SM00180
Domain	Receptor_IA-2	PTPRN PTPRN2	1.72e-05	2	78	2	PF11548
Domain	Receptor_IA-2_dom	PTPRN PTPRN2	1.72e-05	2	78	2	IPR021613
Domain	KRAB	ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF689 ZNF205 ZNF470 ZNF418	1.80e-05	358	78	9	PS50805
Domain	KRAB	ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF689 ZNF205 ZNF470 ZNF418	1.80e-05	358	78	9	PF01352
Domain	Laminin_EGF	NTN4 LAMB4 CELSR3 MEGF11	1.87e-05	38	78	4	IPR002049
Domain	KRAB	ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF689 ZNF205 ZNF470 ZNF418	2.28e-05	369	78	9	SM00349
Domain	KRAB	ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF689 ZNF205 ZNF470 ZNF418	2.33e-05	370	78	9	IPR001909
Domain	RESP18	PTPRN PTPRN2	5.15e-05	3	78	2	PF14948
Domain	RESP18_dom	PTPRN PTPRN2	5.15e-05	3	78	2	IPR029403
Domain	PLAC	ADAMTS19 ADAMTS7 ADAMTSL4	6.47e-05	19	78	3	PS50900
Domain	PLAC	ADAMTS19 ADAMTS7 ADAMTSL4	6.47e-05	19	78	3	IPR010909
Domain	ADAM_spacer1	ADAMTS19 ADAMTS7 ADAMTSL4	1.17e-04	23	78	3	IPR010294
Domain	ADAM_spacer1	ADAMTS19 ADAMTS7 ADAMTSL4	1.17e-04	23	78	3	PF05986
Domain	TSP_1	ADAMTS19 CILP2 ADAMTS7 ADAMTSL4	1.39e-04	63	78	4	PF00090
Domain	TSP1	ADAMTS19 CILP2 ADAMTS7 ADAMTSL4	1.57e-04	65	78	4	SM00209
Domain	TSP1_rpt	ADAMTS19 CILP2 ADAMTS7 ADAMTSL4	1.57e-04	65	78	4	IPR000884
Domain	TSP1	ADAMTS19 CILP2 ADAMTS7 ADAMTSL4	1.57e-04	65	78	4	PS50092
Domain	WxxW_domain	CILP2 CEMIP	2.55e-04	6	78	2	IPR025155
Domain	Mucin2_WxxW	CILP2 CEMIP	2.55e-04	6	78	2	PF13330
Domain	EGF_LAM_2	NTN4 LAMB4 CELSR3	2.62e-04	30	78	3	PS50027
Domain	EGF_LAM_1	NTN4 LAMB4 CELSR3	2.62e-04	30	78	3	PS01248
Domain	zf-C2H2_6	ZNF133 ZNF155 ZNF408 E4F1 ZNF418 ZNF574 ZNF646	3.38e-04	314	78	7	PF13912
Domain	Peptidase_M12B_N	ADAMTS19 ADAMTS7 ADAM11	5.75e-04	39	78	3	IPR002870
Domain	Pep_M12B_propep	ADAMTS19 ADAMTS7 ADAM11	5.75e-04	39	78	3	PF01562
Domain	DISINTEGRIN_1	ADAMTS19 ADAMTS7 ADAM11	6.19e-04	40	78	3	PS00427
Domain	Reprolysin	ADAMTS19 ADAMTS7 ADAM11	6.19e-04	40	78	3	PF01421
Domain	ADAM_MEPRO	ADAMTS19 ADAMTS7 ADAM11	6.19e-04	40	78	3	PS50215
Domain	DISINTEGRIN_2	ADAMTS19 ADAMTS7 ADAM11	6.19e-04	40	78	3	PS50214
Domain	Peptidase_M12B	ADAMTS19 ADAMTS7 ADAM11	6.19e-04	40	78	3	IPR001590
Domain	Disintegrin_dom	ADAMTS19 ADAMTS7 ADAM11	6.66e-04	41	78	3	IPR001762
Domain	EGF_1	NTN4 LAMB4 CELSR3 ADAM11 LRP1B MEGF11	6.90e-04	255	78	6	PS00022
Domain	EGF-like_CS	NTN4 LAMB4 CELSR3 ADAM11 LRP1B MEGF11	7.79e-04	261	78	6	IPR013032
Domain	PLAC	ADAMTS19 ADAMTSL4	1.52e-03	14	78	2	PF08686
Domain	Channel_four-helix_dom	CACNA1S KCNV2 TPCN1	1.74e-03	57	78	3	IPR027359
Domain	-	CACNA1S KCNV2 TPCN1	1.74e-03	57	78	3	1.20.120.350
Domain	Laminin_N	NTN4 LAMB4	1.99e-03	16	78	2	IPR008211
Domain	LAMININ_NTER	NTN4 LAMB4	1.99e-03	16	78	2	PS51117
Domain	Laminin_N	NTN4 LAMB4	1.99e-03	16	78	2	PF00055
Domain	LamNT	NTN4 LAMB4	1.99e-03	16	78	2	SM00136
Domain	EGF_extracell	ADAM11 LRP1B MEGF11	2.02e-03	60	78	3	IPR013111
Domain	EGF_2	ADAM11 LRP1B MEGF11	2.02e-03	60	78	3	PF07974
Domain	F-box	CCNF FBXO41 FBXL6	2.77e-03	67	78	3	PF00646
Domain	FBOX	CCNF FBXO41 FBXL6	3.40e-03	72	78	3	PS50181
Domain	F-box_dom	CCNF FBXO41 FBXL6	3.81e-03	75	78	3	IPR001810
Domain	Peptidase_M12B_ADAM-TS	ADAMTS19 ADAMTS7	4.48e-03	24	78	2	IPR013273
Domain	MetalloPept_cat_dom	ADAMTS19 ADAMTS7 ADAM11	4.73e-03	81	78	3	IPR024079
Domain	-	ADAMTS19 ADAMTS7 ADAM11	4.73e-03	81	78	3	3.40.390.10
Domain	EGF_2	LAMB4 CELSR3 ADAM11 LRP1B MEGF11	5.04e-03	265	78	5	PS01186
Domain	ACR	ADAMTS19 ADAM11	5.65e-03	27	78	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS19 ADAM11	5.65e-03	27	78	2	IPR006586
Domain	ZINC_PROTEASE	ADAMTS19 ADAMTS7 ADAM11	8.02e-03	98	78	3	PS00142
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SP1 SFPQ RBM27 ZNF644 TAF1C POLR2K ZNF205 G2E3 RNF40 E4F1 ZFX NDUFS8 FBXL6 ZC3HAV1	1.38e-06	1294	80	14	30804502
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CELSR3 RBM27 CDK12 FBXO41 KDM3B G2E3 RNF40 TPCN1 ZNF646	3.62e-06	529	80	9	14621295
Pubmed	Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.	PTPRN PTPRN2	5.23e-06	2	80	2	16269463
Pubmed	Celsr3 and Fzd3 in axon guidance.	CELSR3 FZD3	5.23e-06	2	80	2	25813877
Pubmed	ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1.	SP1 ESR2	5.23e-06	2	80	2	23756706
Pubmed	The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.	PTPRN PTPRN2	5.23e-06	2	80	2	11206415
Pubmed	The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning.	PTPRN PTPRN2	5.23e-06	2	80	2	24662847
Pubmed	Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes.	PTPRN PTPRN2	5.23e-06	2	80	2	8798755
Pubmed	Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.	PTPRN PTPRN2	5.23e-06	2	80	2	19361477
Pubmed	Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain.	PTPRN PTPRN2	5.23e-06	2	80	2	23595248
Pubmed	Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity.	CELSR3 FZD3	5.23e-06	2	80	2	34308297
Pubmed	Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma.	PTPRN PTPRN2	5.23e-06	2	80	2	8024693
Pubmed	Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles.	PTPRN PTPRN2	5.23e-06	2	80	2	21732083
Pubmed	Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.	PTPRN PTPRN2	5.23e-06	2	80	2	18310453
Pubmed	Pathophysiologic changes in IA-2/IA-2β null mice are secondary to alterations in the secretion of hormones and neurotransmitters.	PTPRN PTPRN2	5.23e-06	2	80	2	25861885
Pubmed	The increased Sprouty4 expression in response to serum is transcriptionally controlled by Specific protein 1.	SP1 SPRY4	5.23e-06	2	80	2	25957915
Pubmed	Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice.	PTPRN PTPRN2	5.23e-06	2	80	2	16306340
Pubmed	Common and female-specific roles of protein tyrosine phosphatase receptors N and N2 in mice reproduction.	PTPRN PTPRN2	5.23e-06	2	80	2	36611058
Pubmed	Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F.	PTPRN PTPRN2	5.23e-06	2	80	2	9858807
Pubmed	Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.	PTPRN PTPRN2	5.23e-06	2	80	2	19019914
Pubmed	A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.	TRADD TRAF2	5.23e-06	2	80	2	10892748
Pubmed	Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease.	CELSR3 FZD3	5.23e-06	2	80	2	27619161
Pubmed	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	TRAF2 MST1L	1.57e-05	3	80	2	26698664
Pubmed	Regulation of a disintegrins and metalloproteinase with thrombospondin motifs 7 during inflammation in nucleus pulposus (NP) cells: role of AP-1, Sp1 and NF-κB signaling.	SP1 ADAMTS7	1.57e-05	3	80	2	27516213
Pubmed	betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system.	PTPRN PTPRN2	1.57e-05	3	80	2	11086001
Pubmed	Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity.	PTPRN PTPRN2	1.57e-05	3	80	2	12364328
Pubmed	Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.	SP1 ESR2	1.57e-05	3	80	2	10681512
Pubmed	Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2β, and GAD65.	PTPRN PTPRN2	1.57e-05	3	80	2	26148972
Pubmed	The Ia-2β intronic miRNA, miR-153, is a negative regulator of insulin and dopamine secretion through its effect on the Cacna1c gene in mice.	PTPRN PTPRN2	1.57e-05	3	80	2	26141787
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS19 CILP2 ADAMTS7 ADAMTSL4	2.79e-05	75	80	4	20637190
Pubmed	UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.	ZNF689 TAF1C RECQL4 ZNF574 ZNF646	3.03e-05	155	80	5	34921745
Pubmed	Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors.	TRADD TRAF2	3.13e-05	4	80	2	11112773
Pubmed	Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway.	TRADD TRAF2	3.13e-05	4	80	2	10911999
Pubmed	Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β.	PTPRN PTPRN2	3.13e-05	4	80	2	22785238
Pubmed	X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability.	TRADD TRAF2	3.13e-05	4	80	2	27768232
Pubmed	The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF.	SP1 TAF1C	3.13e-05	4	80	2	12498690
Pubmed	A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma.	TRADD TRAF2	3.13e-05	4	80	2	22170762
Pubmed	Hepatitis C virus core protein potentiates TNF-alpha-induced NF-kappaB activation through TRAF2-IKKbeta-dependent pathway.	TRADD TRAF2	3.13e-05	4	80	2	11374864
Pubmed	Up-regulated renal expression of TNF-alpha signalling adapter proteins in lupus glomerulonephritis.	TRADD TRAF2	3.13e-05	4	80	2	19151112
Pubmed	The A20 protein interacts with the Epstein-Barr virus latent membrane protein 1 (LMP1) and alters the LMP1/TRAF1/TRADD complex.	TRADD TRAF2	3.13e-05	4	80	2	10544141
Pubmed	The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling.	TRADD TRAF2	3.13e-05	4	80	2	21421854
Pubmed	IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.	PTPRN PTPRN2	5.20e-05	5	80	2	16418280
Pubmed	The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.	TRADD TRAF2	5.20e-05	5	80	2	7758105
Pubmed	Tumor suppressor p53 represses transcription of RECQ4 helicase.	SP1 RECQL4	5.20e-05	5	80	2	15674334
Pubmed	Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses.	CELSR3 FZD3	5.20e-05	5	80	2	34407949
Pubmed	Mapping to chromosomes 1 and 12 of mouse homologs of human protein tyrosine phosphatase, receptor-type, related genes encoding pancreatic beta cell autoantigens.	PTPRN PTPRN2	5.20e-05	5	80	2	9383296
Pubmed	Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins.	TRADD TRAF2	5.20e-05	5	80	2	8702708
Pubmed	TRADD, TRAF2, RIP1 and TAK1 are required for TNF-α-induced pro-labour mediators in human primary myometrial cells.	TRADD TRAF2	5.20e-05	5	80	2	28337828
Pubmed	Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation.	TRADD TRAF2	5.20e-05	5	80	2	11821416
Pubmed	1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2.	TRADD TRAF2	5.20e-05	5	80	2	12796506
Pubmed	MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.	TRADD TRAF2	7.79e-05	6	80	2	9020361
Pubmed	TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.	TRADD TRAF2	7.79e-05	6	80	2	8565075
Pubmed	Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death.	TRADD TRAF2	7.79e-05	6	80	2	11479302
Pubmed	SOCS-1 ameliorates smoke inhalation-induced acute lung injury through inhibition of ASK-1 activity and DISC formation.	TRADD TRAF2	7.79e-05	6	80	2	29108854
Pubmed	Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1.	TRADD TRAF2	7.79e-05	6	80	2	16611992
Pubmed	The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.	TRADD TRAF2	7.79e-05	6	80	2	8943045
Pubmed	Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.	TRADD TRAF2	7.79e-05	6	80	2	10980203
Pubmed	Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death.	TRADD TRAF2	7.79e-05	6	80	2	11181075
Pubmed	TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.	TRADD TRAF2	7.79e-05	6	80	2	8612133
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZDHHC2 SP1 ZNF644 ZNF689 ESR2 KDM3B ZNF205 ZC3HAV1 ZNF646	1.00e-04	808	80	9	20412781
Pubmed	De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.	TRADD TRAF2	1.09e-04	7	80	2	22179575
Pubmed	Modulation of life and death by the TNF receptor superfamily.	TRADD TRAF2	1.09e-04	7	80	2	9916988
Pubmed	EVER2 protein binds TRADD to promote TNF-α-induced apoptosis.	TRADD TRAF2	1.09e-04	7	80	2	23429285
Pubmed	IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation.	TRADD TRAF2	1.09e-04	7	80	2	18776134
Pubmed	Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.	TRADD TRAF2	1.09e-04	7	80	2	23955153
Pubmed	Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation.	TRADD TRAF2	1.09e-04	7	80	2	19287455
Pubmed	Spatiotemporal regulation of GLI target genes in the mammalian limb bud.	ADAMTS19 SP1 POLR2K FBXO41 TPCN1	1.19e-04	207	80	5	26238476
Pubmed	TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.	TRADD TRAF2	1.45e-04	8	80	2	14585990
Pubmed	Protocadherin Celsr3 is crucial in axonal tract development.	CELSR3 FZD3	1.45e-04	8	80	2	15778712
Pubmed	Interplay between polypyrimidine tract binding protein-associated splicing factor and human myometrial progesterone receptors.	SP1 SFPQ	1.45e-04	8	80	2	19339282
Pubmed	Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice.	TRADD TRAF2	1.45e-04	8	80	2	10702415
Pubmed	TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.	TRADD TRAF2	1.45e-04	8	80	2	19815541
Pubmed	Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634.	TRADD TRAF2	1.45e-04	8	80	2	36185580
Pubmed	Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.	NR4A2 KDM3B LRP1B	1.66e-04	46	80	3	21102462
Pubmed	Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.	ST3GAL2 COLGALT1 MGAT5B	1.66e-04	46	80	3	2649653
Pubmed	Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.	TRADD TRAF2	1.86e-04	9	80	2	16603398
Pubmed	IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.	TRADD TRAF2	1.86e-04	9	80	2	21813773
Pubmed	Mechanisms of caspase activation.	TRADD TRAF2	1.86e-04	9	80	2	14644197
Pubmed	Expression of planar cell polarity genes during development of the mouse CNS.	CELSR3 FZD3	1.86e-04	9	80	2	16487141
Pubmed	Celsr3 is required in motor neurons to steer their axons in the hindlimb.	CELSR3 FZD3	2.32e-04	10	80	2	25108913
Pubmed	Estrogen receptor (ER) beta or p53 attenuates ERalpha-mediated transcriptional activation on the BRCA2 promoter.	SP1 ESR2	2.32e-04	10	80	2	18765668
Pubmed	NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.	TRADD TRAF2	2.32e-04	10	80	2	15485837
Pubmed	Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem.	CELSR3 FZD3	2.32e-04	10	80	2	21106844
Pubmed	Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.	ADAMTS19 ADAMTS7	2.84e-04	11	80	2	29337306
Pubmed	Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.	TRADD TRAF2	2.84e-04	11	80	2	18990758
Pubmed	A dual role for planar cell polarity genes in ciliated cells.	CELSR3 FZD3	2.84e-04	11	80	2	25024228
Pubmed	Celsr3 and Fzd3 Organize a Pioneer Neuron Scaffold to Steer Growing Thalamocortical Axons.	CELSR3 FZD3	2.84e-04	11	80	2	27170656
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	NTN4 CELSR3 PTPRN FZD3 ZNF689	2.91e-04	251	80	5	29031500
Pubmed	Planar cell polarity genes control the connectivity of enteric neurons.	CELSR3 FZD3	3.40e-04	12	80	2	23478408
Pubmed	AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.	TRADD TRAF2	3.40e-04	12	80	2	15310755
Pubmed	Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components.	TRADD TRAF2	3.40e-04	12	80	2	24735611
Pubmed	Zinc finger protein genes in the mouse genome.	SP1 ZFX	3.40e-04	12	80	2	1797234
Pubmed	Tumour necrosis factor signalling in health and disease.	TRADD TRAF2	3.40e-04	12	80	2	30755793
Pubmed	TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.	TRADD TRAF2	3.40e-04	12	80	2	31390091
Pubmed	Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice.	CELSR3 FZD3	3.40e-04	12	80	2	20631168
Pubmed	Collagen XIV is important for growth and structural integrity of the myocardium.	COLGALT1 PLOD1	3.40e-04	12	80	2	22906538
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	PTPRN2 NR4A2 KDM3B LRP1B	3.97e-04	149	80	4	25231870
Pubmed	Common cellular origin and diverging developmental programs for different sesamoid bones.	CACNA1S TNMD	4.01e-04	13	80	2	30745426
Pubmed	Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.	SFPQ NR4A2	4.01e-04	13	80	2	19144721
Pubmed	The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.	TRADD TRAF2	4.01e-04	13	80	2	11035039
Interaction	NOTCH2 interactions	CCNF SP1 CILP2 ZNF341 ZNF689 ZNF408 ESR2 E4F1 ZNF574 ZNF646	5.91e-06	423	79	10	int:NOTCH2
Interaction	DHX57 interactions	SFPQ ZNF689 ESR2 RECQL4 MGAT5B FBXL6 ZNF574 ZC3HAV1	6.49e-06	252	79	8	int:DHX57
Interaction	TIMM23B interactions	SFPQ CDK12 ESR2 RECQL4	1.04e-05	35	79	4	int:TIMM23B
Interaction	MRPS25 interactions	CCNF ESR2 RECQL4 MRPS21 E4F1 FBXL6 ZNF574 ZC3HAV1	1.04e-05	269	79	8	int:MRPS25
Interaction	MRPS24 interactions	CCNF ZNF133 RECQL4 MRPS21 E4F1 FBXL6 ZNF574 ZC3HAV1	1.26e-05	276	79	8	int:MRPS24
Interaction	XAGE1A interactions	CELSR3 FZD3 E4F1 ZNF574	1.98e-05	41	79	4	int:XAGE1A
Interaction	SRSF4 interactions	SFPQ CDK12 ZNF689 ESR2 RECQL4 ZNF574 ZC3HAV1 ZNF646	2.29e-05	300	79	8	int:SRSF4
Interaction	NSA2 interactions	CCNF ESR2 E4F1 FBXL6 ZNF574 ZC3HAV1 ZNF646	2.89e-05	225	79	7	int:NSA2
Interaction	MRPS31 interactions	ZNF689 ESR2 RECQL4 MRPS21 E4F1 FBXL6 ZNF574 ZC3HAV1	2.90e-05	310	79	8	int:MRPS31
Interaction	DAP3 interactions	CCNF ZNF133 ZNF408 ESR2 RECQL4 E4F1 ZNF574 ZC3HAV1	3.96e-05	324	79	8	int:DAP3
Interaction	ZNF574 interactions	TRAF2 ZNF689 ESR2 E4F1 LRP1B ZNF574 ZC3HAV1	5.09e-05	246	79	7	int:ZNF574
Interaction	MRPS7 interactions	CCNF ZNF133 ZNF408 RECQL4 E4F1 FBXL6 ZNF574 ZC3HAV1	7.53e-05	355	79	8	int:MRPS7
Interaction	CPNE3 interactions	CCNF ESR2 RECQL4 KDM3B COLGALT1	9.30e-05	116	79	5	int:CPNE3
Interaction	VWCE interactions	CILP2 ZNF408 RECQL4 E4F1	1.16e-04	64	79	4	int:VWCE
Interaction	EFEMP1 interactions	TRAF2 ZNF408 ESR2 E4F1 ZNF646	1.23e-04	123	79	5	int:EFEMP1
Interaction	MRPS9 interactions	ZNF689 ESR2 RECQL4 MRPS21 E4F1 FBXL6 ZNF574 ZC3HAV1	1.25e-04	382	79	8	int:MRPS9
Interaction	CENPB interactions	ZNF517 SHFL ZNF408 ZNF418 ZNF574	1.27e-04	124	79	5	int:CENPB
Interaction	LTBP4 interactions	ZNF517 ZNF408 E4F1 ZNF574	1.39e-04	67	79	4	int:LTBP4
Interaction	MRPS2 interactions	ZNF133 ESR2 RECQL4 MRPS21 E4F1 ZNF574 ZC3HAV1	1.42e-04	290	79	7	int:MRPS2
Interaction	KRTAP10-7 interactions	ZNF133 ZNF155 ZNF337 SHFL ZNF408 E4F1 ZNF418	1.52e-04	293	79	7	int:KRTAP10-7
Interaction	SRSF6 interactions	CCNF CENPC CDK12 ZNF689 TAF1C RECQL4 MRPS21 ZNF574 ZC3HAV1	1.53e-04	503	79	9	int:SRSF6
Interaction	RPL36 interactions	CCNF CENPC CDK12 ZNF689 ESR2 TAF1C RECQL4 ZC3HAV1 ZNF646	1.55e-04	504	79	9	int:RPL36
Interaction	FHL2 interactions	SP1 TRAF2 SFPQ RBM27 ZNF408 SPRY4 E4F1 IKZF4	1.60e-04	396	79	8	int:FHL2
Interaction	MRPS23 interactions	ZNF133 ESR2 RECQL4 MRPS21 E4F1 ZNF574 ZC3HAV1	1.61e-04	296	79	7	int:MRPS23
Interaction	ASCC1 interactions	TRAF2 ESR2 RECQL4 FBXL6	1.74e-04	71	79	4	int:ASCC1
Cytoband	8q24.3	ZNF34 ZNF517 RECQL4 FBXL6	4.76e-05	113	80	4	8q24.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SP1 ZNF34 ZNF133 ZNF155 ZNF517 ZNF337 ZNF341 ZNF689 ZNF408 ZNF205 ZNF470 E4F1 ZNF784 ZNF418 IKZF4 ZFX ZNF574 ZNF646	3.17e-11	718	64	18	28
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS19 ADAMTS7	2.03e-03	19	64	2	50
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRN PTPRN2	2.48e-03	21	64	2	813
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#4_top-relative-expression-ranked_1000	ZDHHC2 SPRY4 NR4A2 TNMD MEGF11 RNF227 IKZF4 CEMIP	1.87e-05	307	79	8	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_1000_k4
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Cpne5-Inhibitory_Gad1Gad2_Htr3a.Cpne5_(Interneuron,__(candidate_CGE-derived_5))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GRXCR2 ESR2 TNMD RUFY4	5.78e-06	65	80	4	a4873ffa71ac0016c9abce82cb4e1060946627cd
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Cpne5-Inhibitory_Gad1Gad2_Htr3a.Cpne5_(Interneuron,__(candidate_CGE-derived_5))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GRXCR2 ESR2 TNMD RUFY4	5.78e-06	65	80	4	9cc767bfb26231af3bdb9423978b68ee42797cf4
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Cpne5\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GRXCR2 ESR2 TNMD RUFY4	5.78e-06	65	80	4	db5db7d5811a714535bdb367c5e2863a3edf89a0
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC2 PTPRN PTPRN2 FBXO41 ZNF784	1.93e-05	182	80	5	1923932a9c60e9ec33db69ded441210d1fb07bec
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC2 PTPRN PTPRN2 FBXO41 ZNF784	1.93e-05	182	80	5	69ff652f74cc47fbe0bd665ab17c445c5b959dad
Drug	Tadjakonine [11087-94-8]; Down 200; 7.4uM; PC3; HT_HG-U133A	SP1 TRADD TRAF2 CELSR3 PTPRN2 NR4A2 ZNF205	5.50e-06	194	80	7	4599_DN
Drug	Vancomycin hydrochloride [1404-93-9]; Down 200; 2.6uM; HL60; HT_HG-U133A	ZNF34 TRADD TRAF2 CELSR3 PTPRN2 FZD3 TAF1C	6.08e-06	197	80	7	2498_DN
Drug	Glafenine hydrochloride [65513-72-6]; Up 200; 9.8uM; PC3; HT_HG-U133A	CCNF ZNF34 SHFL ZNF408 NR4A2 ZNF205 ZFX	6.28e-06	198	80	7	7257_UP
Disease	adverse effect, response to xenobiotic stimulus	CENPC VWA3B LRP1B	5.00e-04	59	77	3	EFO_0009658, GO_0009410
Disease	lysophosphatidylcholine 15:0 measurement	FBXO41 LRP1B	5.99e-04	14	77	2	EFO_0020941
Disease	response to hydrochlorothiazide, systolic blood pressure change measurement	ZDHHC2 TAF1C	7.88e-04	16	77	2	EFO_0005202, EFO_0006944
Disease	Abnormal behavior	NR4A2 KDM3B	7.88e-04	16	77	2	C0233514
Disease	anxiety disorder (implicated_via_orthology)	ESR2 KDM3B	1.50e-03	22	77	2	DOID:2030 (implicated_via_orthology)
Disease	inflammatory bowel disease (implicated_via_orthology)	ESR2 MST1L	1.94e-03	25	77	2	DOID:0050589 (implicated_via_orthology)
Disease	diabetes mellitus (implicated_via_orthology)	PTPRN PTPRN2	2.10e-03	26	77	2	DOID:9351 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CVRGRYEARQRKCPK	RNF40	971	O75150
RPKICCPRYGERRQT	CDK12	701	Q9NYV4
QRCELNCRPRGFRFY	ADAMTSL4	416	Q6UY14
GYFLCIRNARRPSRK	CEACAM20	466	Q6UY09
CRRCKYEPRGVSCRE	ADAM11	491	O75078
ESCRCLPRGLKRAYR	FBXL6	506	Q8N531
GRACRSYRVRFLCGK	CEMIP	391	Q8WUJ3
YCVGERKRFRLCNLQ	ADAMTS7	576	Q9UKP4
KRRCRDYDERGFCVL	RBM27	276	Q9P2N5
EARDCNGPRKQYRIC	ADAMTS19	666	Q8TE59
FRRKVNKCYRGRSCP	PTPRN2	926	Q92932
RGLRTMYRRRSQCCP	MEGF11	76	A6BM72
RRKVNKCYRGRSCPI	PTPRN	891	Q16849
SCRRGFKPCYNRRCI	LRP1B	2551	Q9NZR2
VTYLILACCQGPRRR	TMBIM1	146	Q969X1
KCGSRRERCGYRLVR	ESR2	216	Q92731
NRFKESYRALRCPAC	GRXCR2	221	A6NFK2
RPGTRVGFCYQIRRC	MST1L	331	Q2TV78
GSNTKYRRLCPCRDF	MGAT5B	766	Q3V5L5
YRRLCPCRDFRKGQV	MGAT5B	771	Q3V5L5
CDRGQLKYPRCIPRQ	F13B	636	P05160
GVCLDCYRLRKSRPR	KDM3B	1051	Q7LBC6
RFLRYNCSIRAPRKG	PLOD1	681	Q02809
LRRYPSGEERCIACK	NDUFS8	101	O00217
PRCKRSYHFPCGLQR	G2E3	96	Q7L622
RRCRCKEGRDYNAPD	G2E3	236	Q7L622
RLLRRCPYHFVCRGK	ADCY1	1026	Q08828
PRNCRKCPRTYRLLG	ASPHD2	241	Q6ICH7
CAKCFCYPTKRRIRR	CCNF	11	P41002
RQCVQYALKARPLRC	CACNA1S	1086	Q13698
LDHLKNGYRRRFCRP	CENPC	6	Q03188
CRTFPITGLRYRCLK	DYTN	231	A2CJ06
LPYRCPRCGEHKRFR	FBXO41	6	Q8TF61
EYGRVTLPCRRLCQR	FZD3	91	Q9NPG1
CDRCRPLFYRDPLKT	LAMB4	371	A4D0S4
VRERRFRCGDCGKLY	E4F1	486	Q66K89
ARREGGYTCVCRPRF	CELSR3	1451	Q9NYQ7
AYIPIRKRDRRGCFA	COLGALT1	216	Q8NBJ5
SSIGRRYPRKRCICC	PIP4P1	201	Q86T03
RYPRKRCICCFLLGL	PIP4P1	206	Q86T03
KCPFCNYACRRRDAL	IKZF4	216	Q9H2S9
PVDKRRRNRCQYCRF	NR4A2	306	P43354
AQRGYDRLRRPGCRC	SPRY4	261	Q9C004
RFCGRQPCGRFLRAY	TRADD	76	Q15628
CQRCKPGFYRDLRRP	NTN4	371	Q9HB63
NFRPCYLRVCKVLRE	RECQL4	616	O94761
LFRGGCRYRKRPRVV	TAF1C	86	Q15572
RLKYTPRCCRICFEE	KCNV2	191	Q8TDN2
KIFGRFSRRYPCRLC	RUFY4	526	Q6ZNE9
CYRPFNLGCRAPRRL	RNF227	21	A6NIN4
YRFRDPHQCRRCAVV	ST3GAL2	141	Q16842
GRRTRREACTCPYCK	SP1	596	P08047
GRRCSNYHVRFRCPL	CILP2	131	Q8IUL8
RRPGEKTYTQRCRLF	SFPQ	286	P23246
RCRKCRKRYEPVPAD	SHFL	131	Q9NUL5
KYLCSACRNVLRRPF	TRAF2	31	Q12933
RGNRYCRRVCEPLLG	TNMD	271	Q9H2S6
CQKVFPCERYLRRHL	ZNF341	571	Q9BYN7
HRRYYEKPCCRRQRE	MRPS21	41	P82921
CQECGVRFHRPYRLL	ZNF574	581	Q6ZN55
PYKCRECPRSFLLRR	ZNF574	606	Q6ZN55
RRYRCGECGKAFLQL	ZNF408	351	Q9H9D4
RRFRCSECGKAFRLR	ZNF646	1256	O15015
RPYECLECGKAFRQR	ZNF470	591	Q6ECI4
RDPIRCRECGYRIMY	POLR2K	31	P53803
PYRCLRCGQRFIRGS	ZNF517	316	Q6ZMY9
PYACKECGRCFRQRT	ZNF133	381	P52736
RPYACRECGRTFRDR	ZNF644	446	Q9H582
DCRYCGGVRRNLRQI	TPCN1	211	Q9ULQ1
EKPYTCLECNRRFRQ	ZNF689	286	Q96CS4
PYVCDRCAKRFTRRS	ZNF205	391	O95201
ERPYECRECRKLFRG	ZNF418	451	Q8TF45
DLPFRCKRCRKGFRQ	ZFX	716	P17010
PSKCEDCGRRYKRRL	ZNF155	511	Q12901
IRYCDRCQLIKPDRC	ZDHHC2	126	Q9UIJ5
RVCRRKYCQRPCDNL	ZC3HAV1	71	Q7Z2W4
YTVLKCNNRREFCPR	VWA3B	1131	Q502W6
AVCGDCLPRFYRKTR	EDA2R	81	Q9HAV5
IRDRLGRKPCEYQEC	ZNF861P	56	O60384
RLDFRFRYPEAKCCQ	TMEM145	56	Q8NBT3
PYRCDECGKTFTRRP	ZNF34	306	Q8IZ26
KPYGCRECGRRFRDK	ZNF337	486	Q9Y3M9
AALVLVCRQRYCRPR	TMEM98	21	Q9Y2Y6
ERPYRCALCPRAFKA	ZNF784	126	Q8NCA9