Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	ANKRD9 AMBRA1 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	4.28e-05	82	155	6	GO:1990756
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	ANKRD9 AMBRA1 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	9.77e-05	95	155	6	GO:0140767
GeneOntologyCellularComponent	acrosomal vesicle	SPATA31A3 ADAM15 SPATA31A7 PRAMEF1 PRAMEF2 PRAMEF13 SPATA31A5 SPATA31A1 EHHADH MROH2B	3.29e-06	206	155	10	GO:0001669
GeneOntologyCellularComponent	cilium	DNHD1 DCDC2 OFD1 ADAM15 TOGARAM2 PEX6 AMBRA1 PRAMEF1 PRAMEF2 PRAMEF13 SHANK3 ULK3 DNAAF5 GAS2L2 MROH2B DLEC1 STRC STRCP1	1.23e-04	898	155	18	GO:0005929
GeneOntologyCellularComponent	9+2 non-motile cilium	DCDC2 STRC STRCP1	1.37e-04	14	155	3	GO:0097732
GeneOntologyCellularComponent	kinocilium	DCDC2 STRC STRCP1	1.37e-04	14	155	3	GO:0060091
GeneOntologyCellularComponent	Scrib-APC-beta-catenin complex	SCRIB CTNNB1	1.63e-04	3	155	2	GO:0034750
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	ANKRD9 FBXL15 AMBRA1 PRAMEF1 PRAMEF2 PRAMEF13 ANAPC1 PRAMEF14	1.89e-04	212	155	8	GO:0031461
GeneOntologyCellularComponent	intracellular protein-containing complex	POLD1 ANKRD9 FBXL15 AMBRA1 CARD10 MON1B PRAMEF1 PRAMEF2 PRAMEF13 ECT2 WDR26 MALT1 CCT8L2 ANAPC1 PRAMEF14 BLOC1S3 CTNNB1 CCT8L1P	3.24e-04	972	155	18	GO:0140535
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	4.05e-04	47	155	4	GO:0031462
GeneOntologyCellularComponent	CBM complex	CARD10 MALT1	5.38e-04	5	155	2	GO:0032449
GeneOntologyCellularComponent	ubiquitin ligase complex	ANKRD9 FBXL15 AMBRA1 PRAMEF1 PRAMEF2 PRAMEF13 WDR26 ANAPC1 PRAMEF14	1.28e-03	352	155	9	GO:0000151
Domain	-	LRRC75B MFHAS1 VASN PIDD1 FBXL15 TPBGL PRAMEF1 PRAMEF2 LGI4 PRAMEF13 LRG1 LRRC26 LRCH4 LINGO4 SCRIB LRRN4	5.11e-09	321	147	16	3.80.10.10
Domain	L_dom-like	LRRC75B MFHAS1 VASN PIDD1 FBXL15 TPBGL PRAMEF1 PRAMEF2 LGI4 PRAMEF13 LRG1 LRRC26 LRCH4 LINGO4 SCRIB LRRN4	6.94e-09	328	147	16	IPR032675
Domain	LRR_8	MFHAS1 VASN PIDD1 TPBGL LGI4 LRG1 LRRC26 LRCH4 LINGO4 SCRIB LRRN4	1.11e-07	171	147	11	PF13855
Domain	LRR_TYP	MFHAS1 VASN PIDD1 TPBGL LGI4 LRG1 LRRC26 LRCH4 LINGO4 SCRIB LRRN4	1.57e-07	177	147	11	SM00369
Domain	Leu-rich_rpt_typical-subtyp	MFHAS1 VASN PIDD1 TPBGL LGI4 LRG1 LRRC26 LRCH4 LINGO4 SCRIB LRRN4	1.57e-07	177	147	11	IPR003591
Domain	Leu-rich_rpt	LRRC75B MFHAS1 VASN PIDD1 FBXL15 TPBGL LGI4 LRG1 LRRC26 LRCH4 LINGO4 SCRIB LRRN4	2.34e-07	271	147	13	IPR001611
Domain	Cys-rich_flank_reg_C	VASN TPBGL LGI4 LRG1 LRRC26 LINGO4 LRRN4	7.02e-06	90	147	7	IPR000483
Domain	LRRCT	VASN TPBGL LGI4 LRG1 LRRC26 LINGO4 LRRN4	7.02e-06	90	147	7	SM00082
Domain	LRR_1	MFHAS1 VASN PIDD1 LGI4 LRG1 LRRC26 LRCH4 LINGO4 SCRIB LRRN4	9.39e-06	219	147	10	PF00560
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	9.98e-05	12	147	3	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	9.98e-05	12	147	3	IPR027970
Domain	BRINP	BRINP1 BRINP2	1.84e-04	3	147	2	IPR033237
Domain	Stereocilin-rel	STRC MSLN	1.84e-04	3	147	2	IPR026664
Domain	LRR	MFHAS1 VASN PIDD1 LGI4 LRG1 LRCH4 LINGO4 SCRIB	1.95e-04	201	147	8	PS51450
Domain	ARM-type_fold	RNPEPL1 UBR4 TOGARAM2 DNAAF5 URB1 UPF2 MROH2B IFRD2 LTN1 CTNNB1	3.59e-04	339	147	10	IPR016024
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	3.65e-04	4	147	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	3.65e-04	4	147	2	PF08429
Domain	PRAME_family	PRAMEF1 PRAMEF2 PRAMEF13	4.22e-04	19	147	3	IPR026271
Domain	zf-C5HC2	KDM5C KDM5D	6.06e-04	5	147	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	6.06e-04	5	147	2	IPR004198
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NR2F6 SETD1B KMT2B OFD1 MFHAS1 ANKRD9 RNPEPL1 UBR4 SREBF1 PEX6 AMBRA1 CARD10 TTYH3 ZZEF1 EML3 C2CD2L PRR12 GDPD5 RADIL URB1 IFRD2 KCNQ2 DHX34 PLK3 PRRC2B	2.93e-11	1105	156	25	35748872
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	5.80e-09	6	156	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	5.80e-09	6	156	4	25930072
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	IRS4 OFD1 NOP53 POLD1 KDM5C ANAPC1 LTN1 SCRIB GNAS PRRC2B	1.59e-07	242	156	10	34011540
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.13e-06	18	156	4	23894331
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.13e-06	18	156	4	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.13e-06	18	156	4	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.13e-06	18	156	4	14675769
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.43e-06	19	156	4	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.78e-06	20	156	4	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.78e-06	20	156	4	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.78e-06	20	156	4	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	2.68e-06	22	156	4	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	3.23e-06	23	156	4	19480014
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	3.86e-06	24	156	4	32212159
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	4.58e-06	25	156	4	12620990
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	4.58e-06	25	156	4	37451217
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	5.39e-06	26	156	4	18500982
Pubmed	New nomenclature for chromatin-modifying enzymes.	NCOA3 SETD1B KMT2B KDM5C KDM5D	5.91e-06	57	156	5	18022353
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	7.33e-06	28	156	4	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	9.75e-06	30	156	4	38786026
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	POLD1 KDM5C PRSS56 PEX6 AMBRA1 MAP7 ZZEF1 WDR26 C2CD2L MALT1 ANAPC1 LTN1 RERE SCRIB SRRM2 DHX34 PRRC2B	1.19e-05	1116	156	17	31753913
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.27e-05	32	156	4	37889087
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.83e-05	35	156	4	19389355
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	2.00e-05	2	156	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	2.00e-05	2	156	2	16416087
Pubmed	Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion.	SREBF1 TGFBR1	2.00e-05	2	156	2	27826032
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	2.00e-05	2	156	2	32081420
Pubmed	PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling.	CDHR2 CTNNB1	2.00e-05	2	156	2	19383367
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	2.00e-05	2	156	2	34910522
Pubmed	SOX18 exerts tumor-suppressive functions in papillary thyroid carcinoma through inhibition of Wnt/β-catenin signaling.	SOX18 CTNNB1	2.00e-05	2	156	2	32858034
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	2.00e-05	2	156	2	7524912
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	2.00e-05	2	156	2	11687802
Pubmed	Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia.	GNAS CTNNB1	2.00e-05	2	156	2	22106277
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	2.00e-05	2	156	2	9060413
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	NCOA3 SLC39A4 PRAMEF1 PRAMEF2 PRAMEF13 TGFBR1 DHH PRAMEF14 CTNNB1 NOCT	2.35e-05	424	156	10	21731673
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KMT2B KDM5C KDM5D	2.45e-05	13	156	3	24619213
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CDC42BPG SREBF1 PEX6 AMBRA1 ZZEF1 ECT2 PRR12 UPF2 LRCH4 SCRIB DHX34 PRRC2B	4.01e-05	650	156	12	38777146
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	5.49e-05	46	156	4	17287250
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF1 PRAMEF2 PRAMEF13	5.75e-05	17	156	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF1 PRAMEF2 PRAMEF13	5.75e-05	17	156	3	37781892
Pubmed	The CARMA3-Bcl10-MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor-Positive Breast Cancer.	CARD10 MALT1	5.98e-05	3	156	2	29259013
Pubmed	A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling.	COL18A1 CTNNB1	5.98e-05	3	156	2	18382662
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	5.98e-05	3	156	2	30801007
Pubmed	Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family.	BRINP1 BRINP2	5.98e-05	3	156	2	15193423
Pubmed	Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.	SLC39A4 SHANK3	5.98e-05	3	156	2	28345660
Pubmed	Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli.	SCRIB CTNNB1	5.98e-05	3	156	2	16611247
Pubmed	The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival.	CARD10 MALT1	5.98e-05	3	156	2	28717989
Pubmed	Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.	GNAS CTNNB1	5.98e-05	3	156	2	28810144
Pubmed	The β-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis.	SREBF1 CTNNB1	5.98e-05	3	156	2	23347184
Pubmed	Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells.	BRINP1 BRINP2	5.98e-05	3	156	2	20025061
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	5.98e-05	3	156	2	7544442
Pubmed	Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling.	SCRIB CTNNB1	5.98e-05	3	156	2	21132015
Pubmed	The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis.	CARD10 MALT1	5.98e-05	3	156	2	20605784
Pubmed	FAM83H and SCRIB stabilize β-catenin and stimulate progression of gastric carcinoma.	SCRIB CTNNB1	5.98e-05	3	156	2	32564009
Pubmed	ALK-1 to ALK-5 ratio dictated by the Akt1-β-catenin pathway regulates TGFβ-induced endothelial-to-mesenchymal transition.	TGFBR1 CTNNB1	5.98e-05	3	156	2	33157202
Pubmed	CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells.	CARD10 MALT1	5.98e-05	3	156	2	17101977
Pubmed	B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin.	CTNNB1 FAM83A	5.98e-05	3	156	2	36797256
Pubmed	Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.	GNAS CTNNB1	5.98e-05	3	156	2	34520814
Pubmed	Scribble interacts with beta-catenin to localize synaptic vesicles to synapses.	SCRIB CTNNB1	5.98e-05	3	156	2	19458197
Pubmed	Increased Growth Differentiation Factor 15 in Patients with Hypoleptinemia-Associated Lipodystrophy.	GDF15 SREBF1	5.98e-05	3	156	2	33003626
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF1 PRAMEF2 PRAMEF13	6.87e-05	18	156	3	39181896
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	7.64e-05	50	156	4	31806660
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	DPY19L3 QPCTL FKRP VASN ADAM15 SREBF1 MAP7 ZZEF1 TGFBR1 COL18A1 MICAL2 LTN1 SCRIB CTNNB1 TAPBP MSLN	1.06e-04	1201	156	16	35696571
Pubmed	GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer.	GDF15 TGFBR1	1.19e-04	4	156	2	27235139
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	1.19e-04	4	156	2	18849963
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	1.19e-04	4	156	2	16541399
Pubmed	Endogenous transforming growth factor-beta promotes quiescence of primary microglia in vitro.	TGFBR1 CTNNB1	1.19e-04	4	156	2	23065670
Pubmed	Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons.	ACSM4 GNAS	1.19e-04	4	156	2	24034253
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	1.19e-04	4	156	2	17320160
Pubmed	Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3·Bcl10·MALT1 signalosome.	CARD10 MALT1	1.19e-04	4	156	2	21041303
Pubmed	ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.	CTF1 CTNNB1	1.19e-04	4	156	2	15958533
Pubmed	CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex.	CARD10 MALT1	1.19e-04	4	156	2	20695076
Pubmed	NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.	CTHRC1 CTNNB1	1.19e-04	4	156	2	34512149
Pubmed	Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3β/β-catenin signaling.	GDF15 CTNNB1	1.19e-04	4	156	2	28199981
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	1.19e-04	4	156	2	7951230
Pubmed	GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation.	GDPD5 CTNNB1	1.19e-04	4	156	2	32375055
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	1.19e-04	4	156	2	32732223
Pubmed	Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction.	CARD10 MALT1	1.19e-04	4	156	2	11387339
Pubmed	MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/β-catenin signaling pathway.	MICAL2 CTNNB1	1.19e-04	4	156	2	36064550
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PRPF31 IRS4 OFD1 MAP7 ECT2 WDR26 RADIL STARD9 TMEM102 SCRIB GNAS SRRM2 GEN1	1.45e-04	861	156	13	36931259
Pubmed	Linkage mapping around the ragged (Ra) and wasted (wst) loci on distal mouse chromosome 2.	SOX18 GNAS	1.98e-04	5	156	2	8020960
Pubmed	Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.	SOX18 GNAS	1.98e-04	5	156	2	9271224
Pubmed	Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels.	COL18A1 CTNNB1	1.98e-04	5	156	2	19298526
Pubmed	Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.	SETD1B KMT2B	1.98e-04	5	156	2	25561738
Pubmed	Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance.	IRS4 CRH	1.98e-04	5	156	2	32218485
Pubmed	CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex.	CARD10 MALT1	1.98e-04	5	156	2	19112107
Pubmed	TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.	TGFBR1 CTNNB1	1.98e-04	5	156	2	28622298
Pubmed	A novel Gαs-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.	GAS2L2 GNAS	1.98e-04	5	156	2	23994616
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	1.98e-04	5	156	2	24920589
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	POLD1 FBXL15 CARD10 ECT2 EHHADH	2.14e-04	120	156	5	27565346
Pubmed	A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes.	CRH GNAS	2.96e-04	6	156	2	10598591
Pubmed	Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool.	TGFBR1 CTNNB1	2.96e-04	6	156	2	25849774
Pubmed	Interaction between the transforming growth factor-beta type II receptor/Smad pathway and beta-catenin during transforming growth factor-beta1-mediated adherens junction disassembly.	TGFBR1 CTNNB1	2.96e-04	6	156	2	12000714
Pubmed	The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.	SREBF1 EHHADH CTNNB1	2.97e-04	29	156	3	28364022
Pubmed	Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse.	TGFBR1 DHH CTNNB1	2.97e-04	29	156	3	31845891
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	NCOA3 GDF15 POLD1 CYP27B1 CARD10 TGFBR1 COL18A1 CTNNB1	3.42e-04	381	156	8	18676680
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	DCDC2 TCAF1 CYP27B1 IRGQ PRAMEF1 PRAMEF2 PRAMEF13 TGFBR1 COL18A1 URB1 PRAMEF14 LTN1 GEN1 TAPBP	3.96e-04	1084	156	14	11544199
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PRPF31 SETD1B POLD1 NPEPPS UBR4 AMBRA1 ECT2 RIN1 URB1 UPF2 MICAL2 LTN1 GSDMA SCRIB SRRM2 DHX34	4.03e-04	1353	156	16	29467282
Pubmed	Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization.	SCRIB CTNNB1	4.14e-04	7	156	2	28369449
Interaction	TOP3B interactions	NR2F6 SETD1B KMT2B OFD1 MFHAS1 ANKRD9 RNPEPL1 UBR4 SREBF1 PEX6 AMBRA1 CARD10 TTYH3 ZZEF1 EML3 C2CD2L PRR12 GDPD5 RADIL URB1 UPF2 FASTK IFRD2 KCNQ2 GNAS DHX34 PLK3 PRRC2B	1.79e-06	1470	145	28	int:TOP3B
Cytoband	1p36.21	AADACL3 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	2.55e-06	63	156	5	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	PRPF31 DPY19L3 KMT2B QPCTL FKRP NOP53 POLD1 C5AR2 APLP1 IRGQ LGI4 B3GNT8 PRR12 VSIG10L BLOC1S3 DHX34	3.42e-06	1192	156	16	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	TTYH3 CYP2W1 DNAAF5 RADIL GRID2IP	9.97e-05	134	156	5	chr7p22
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	3.17e-04	8	156	2	chr9q12
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	CDC42BPG MACROD1 KLHL35 TPBGL GDPD5 RIN1 SSH3	9.72e-04	454	156	7	chr11q13
Cytoband	21q22.11	EVA1C URB1 LTN1	1.26e-03	62	156	3	21q22.11
Cytoband	16p13.3	VASN PRSS33 PRR35 SRRM2 MSLN	1.53e-03	244	156	5	16p13.3
Cytoband	19q13.32	QPCTL FKRP BLOC1S3	2.09e-03	74	156	3	19q13.32
Cytoband	20q13.3	KCNQ2 GNAS	2.09e-03	20	156	2	20q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	AADACL3 UBR4 PRAMEF1 PRAMEF2 PRAMEF13 LACTBL1 PRAMEF14 RERE	2.40e-03	681	156	8	chr1p36
Cytoband	19q13.3	NOP53 POLD1 DHX34	2.80e-03	82	156	3	19q13.3
Cytoband	9p13.1	SPATA31A3 SPATA31A1	3.01e-03	24	156	2	9p13.1
Cytoband	15q15.3	STRC STRCP1	3.27e-03	25	156	2	15q15.3
Cytoband	6q23.3	MAP7 SLC35D3	4.09e-03	28	156	2	6q23.3
GeneFamily	PRAME family	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	4.09e-06	24	83	4	686
GeneFamily	PDZ domain containing	MAGIX SHANK3 RADIL GRID2IP SCRIB	6.74e-04	152	83	5	1220
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SH2D3C SOX18 MFSD4A CARD10 SHANK3 GDPD5 SLC22A10	4.35e-07	194	156	8	3c31ac44e8cf4eca3ba7b8bfc05ad3e96a970956
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRRC75B AADACL3 TPBGL PRR29 LINGO4 LRRN4 FAM83A	2.65e-06	173	156	7	0a355386210a13927ea29b10b64cb059459952d4
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRRC75B AADACL3 TPBGL PRR29 LINGO4 LRRN4 FAM83A	2.65e-06	173	156	7	3678b300cad4effd7f49bfb043305ed512693848
ToppCell	facs-Marrow-KLS-18m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCTL TOGARAM2 MFSD4A APLP1 BRINP2 TMEM102 CHST2	2.65e-06	173	156	7	295bfe1efa648173c2d5981025bc61c576baf53f
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C5AR2 SOX18 MFSD4A TPBGL LRG1 COL18A1 MICAL2	2.97e-06	176	156	7	460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 MFSD4A CARD10 SHANK3 GDPD5 CTHRC1	4.42e-06	187	156	7	29b2e2be26a9d72b154760e47acf61cfe2f45fa7
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAM15 SOX18 CARD10 LRG1 SHANK3 EVA1C CTHRC1	4.42e-06	187	156	7	d6765854154557794815514c0aa355bc74b8523e
ToppCell	wk_08-11-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH CTHRC1	4.42e-06	187	156	7	a27aa97aa6508a3ffe92c2b6bb0511a95650a390
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 MFSD4A CARD10 SHANK3 GDPD5 CTHRC1	4.58e-06	188	156	7	b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH CTHRC1	4.91e-06	190	156	7	1307688255a1250fa300edf2c41f1affe31dcc98
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 MFSD4A CARD10 SHANK3 GDPD5 CTHRC1	4.91e-06	190	156	7	7ba2be2630183df86de21689289a8620a4cd507e
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 EVA1C GDPD5 DHH	5.63e-06	194	156	7	efd5efed060edb7f24d59600981bb60ec28ac2ef
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DCDC2 GDF15 MAP7 CRH CYP2W1 KRTCAP3 NECTIN4	5.63e-06	194	156	7	b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical\|TCGA-Thryoid / Sample_Type by Project: Shred V9	CDC42BPG VASN SREBF1 LRG1 RIN1 NECTIN4 CHST2	5.63e-06	194	156	7	b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SH2D3C SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.02e-06	196	156	7	2a2a93b89dcb98043cb1f8b422ac8c55e2edc37b
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SH2D3C SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.22e-06	197	156	7	4e9221cb02122aed2981c3c9157e847a3710e323
ToppCell	368C-Endothelial_cells-Endothelial-A_(Artery)\|368C / Donor, Lineage, Cell class and subclass (all cells)	ADAM15 SH2D3C SOX18 CARD10 SHANK3 EVA1C DHH	6.22e-06	197	156	7	7caa2c86dc4d50b57a7db8f7278d1588282ad6db
ToppCell	368C-Endothelial_cells-Endothelial-A_(Artery)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	ADAM15 SH2D3C SOX18 CARD10 SHANK3 EVA1C DHH	6.22e-06	197	156	7	951f18f326967206adbbfc422cce9eea3d2e0854
ToppCell	Sigmoid-T_cell-cycling_gd_T\|T_cell / Region, Cell class and subclass	DCDC2 FKRP POLD1 ECT2 MICAL2 CTF1 GEN1	6.87e-06	200	156	7	4e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCell	Sigmoid-(1)_T_cell-(18)_cycling_gd_T\|Sigmoid / shred on region, Cell_type, and subtype	DCDC2 FKRP POLD1 ECT2 MICAL2 CTF1 GEN1	6.87e-06	200	156	7	6e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCell	Sigmoid-T_cell-cycling_gd_T\|Sigmoid / Region, Cell class and subclass	DCDC2 FKRP POLD1 ECT2 MICAL2 CTF1 GEN1	6.87e-06	200	156	7	9769185abae084ffac36420c749625e679b70ca8
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SH2D3C C5AR2 KLHL35 MFSD4A PTGER1 LRG1	2.56e-05	165	156	6	50a8513d8d2630861499393a7f102b35366bad37
ToppCell	E16.5-Endothelial-Endothelial_lymphatic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GDF15 SOX18 MFSD4A LRG1 LINGO4 GNAS	2.74e-05	167	156	6	b93103a868fba63a8910bffb690a6242b9252833
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GDF15 SOX18 MFSD4A LRG1 LINGO4 GNAS	2.74e-05	167	156	6	fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GDF15 SOX18 MFSD4A LRG1 LINGO4 GNAS	2.74e-05	167	156	6	f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GDF15 SOX18 MFSD4A LRG1 LINGO4 GNAS	2.74e-05	167	156	6	26cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM15 C5AR2 SOX18 LRG1 CTHRC1 GTPBP3	2.83e-05	168	156	6	3bddf411a60137a8883fc9e77586e4719b0d6067
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	LRRC75B AMBRA1 SLC39A4 DENND2D SCRIB NOCT	2.83e-05	168	156	6	8459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM15 C5AR2 SOX18 LRG1 CTHRC1 GTPBP3	2.83e-05	168	156	6	b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10\|TCGA-Brain / Sample_Type by Project: Shred V9	DCDC2 LGI4 GAS2L2 PRR29 CTF1 DLEC1	3.13e-05	171	156	6	74be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC75B TPBGL PRR29 LINGO4 LRRN4 FAM83A	3.45e-05	174	156	6	aae7ab9df5a78716034ddfd5bd47adc69912d624
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC75B TPBGL PRR29 LINGO4 LRRN4 FAM83A	3.45e-05	174	156	6	d9489c4196d103ead8cb6279492bbe563a222e45
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SHANK3 EVA1C DHH CTNNB1	3.45e-05	174	156	6	3d4c05ea5719ca65e85d1f15198453034791087c
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DCDC2 GDF15 CYP2W1 LRRC26 NECTIN4 SCRIB	3.92e-05	178	156	6	9099b47e0756d6a1b7ba1c6aa7b47c5425f649e0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C DHH	3.92e-05	178	156	6	5f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCell	PCW_05-06-Endothelial-Endothelial_immature-endo_immature3_(11)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	4.17e-05	180	156	6	7d4cb0ab9f96088cbc5db3096d884a1e5ce4cb5d
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOX18 SHANK3 RIN1 DHH MICAL2 CTHRC1	4.30e-05	181	156	6	2c44c41b4e8a75ebdbaeb0c6cc5a03f17c44758c
ToppCell	wk_15-18-Hematologic-Meg-ery-Definitive_erythroblast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	GDF15 ANKRD9 KDM5D WDR26 MICAL2 ATG4D	4.43e-05	182	156	6	93841f730ca1a735eaaf5f2ccbe5c45ab0e029d1
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DCDC2 SLC39A4 MAP7 LRG1 MICAL2 KRTCAP3	4.43e-05	182	156	6	1e2149b222a3e9f64841aed45288a6f29394e7b0
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAM15 SH2D3C CARD10 COL18A1 RADIL CTHRC1	4.57e-05	183	156	6	bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TCAF1 MAGIX SOX18 DHH MICAL2 DLEC1	4.57e-05	183	156	6	351d575339038bd4a66f408da518c567444208e8
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAM15 SH2D3C SOX18 CARD10 SHANK3 SLC22A10	4.71e-05	184	156	6	fa38d6a8709f520a027ad7e3ff783c84187ec467
ToppCell	5'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAM15 PPP1R13B SOX18 LRG1 SHANK3 ARHGAP45	4.71e-05	184	156	6	97e97de52daaff8840f4ee76a94ba5e3f79de7ce
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH	4.71e-05	184	156	6	a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAM15 SOX18 MFSD4A TTYH3 SHANK3 GDPD5	4.86e-05	185	156	6	602536a3308a848f106adcb0a83530997440c8f4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NCOA3 GDF15 UPF2 CHST2 GEN1 SHISA8	5.00e-05	186	156	6	55b239834b96b1f7787ec77a7d19796d617bbbf0
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM15 SOX18 CARD10 LRG1 SHANK3 INKA1	5.16e-05	187	156	6	3548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM15 SOX18 CARD10 LRG1 SHANK3 INKA1	5.16e-05	187	156	6	f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	5.16e-05	187	156	6	106f50ad85a92403037214f0e94702230284837f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM15 SOX18 CARD10 LRG1 SHANK3 INKA1	5.16e-05	187	156	6	81754e965848b718be20ee97ce072ce426938a69
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH	5.16e-05	187	156	6	03de3c2df31bca0dc4e3718bada708d8fe8b69b9
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC2 VASN PTGER1 B3GNT8 COL18A1 PRR35	5.16e-05	187	156	6	b7689e7f6511920cd2beff27389555fddf685f61
ToppCell	P03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAM15 LRG1 EVA1C COL18A1 DHH CTHRC1	5.31e-05	188	156	6	5eb107122064f0a99dfd445cc87d3766f7257216
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH	5.31e-05	188	156	6	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAM15 KLHL35 B3GNT8 COL18A1 DHH CTHRC1	5.31e-05	188	156	6	59f276e23c8380bae57d7ecca3a8b83df4bc150b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C DHH	5.31e-05	188	156	6	c2c51c6526defe2600302901159b8abbb58d7595
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAM15 KLHL35 SOX18 COL18A1 DHH CTHRC1	5.47e-05	189	156	6	d17e8467699c7ca7694a313c26111f085df5204e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SHANK3 EVA1C DHH CTNNB1	5.47e-05	189	156	6	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SH2D3C SOX18 CARD10 SHANK3 RADIL CTHRC1	5.47e-05	189	156	6	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	wk_08-11-Endothelial-Lymph_endothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SOX18 CARD10 SHANK3 GDPD5 MICAL2 CTHRC1	5.63e-05	190	156	6	d7f1dc032d161529559e01832d1a3112c6f6cc1a
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC2 GDF15 VASN PTGER1 COL18A1 PRR35	5.80e-05	191	156	6	65083daf317f66556dc047eb19297dcbe9c70299
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH	5.80e-05	191	156	6	54029b68fb78163c969890886ab0f8fb0dcf3c20
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C DHH	5.97e-05	192	156	6	bacbaef1f230051335f4433e55db07a161b96b4c
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature3_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	5.97e-05	192	156	6	7dbe3117a0f58ff2e838963d49f788a59a4351d7
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ADAM15 SLC39A4 ZZEF1 PRR12 FASTK STARD9	5.97e-05	192	156	6	efbd52b3d2b6d3fb9ed6bc3f36aca9f4f1fcbc49
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C DHH	5.97e-05	192	156	6	3259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C CTNNB1	5.97e-05	192	156	6	56b021c297a21dff357531f21e2464f85186106d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C STARD9	5.97e-05	192	156	6	28eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCell	PCW_05-06-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.14e-05	193	156	6	2661ad9107ed9231e4afea4442a79051139a31df
ToppCell	PCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating3_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.14e-05	193	156	6	f7e4a390921780587b9bd084e495e646fa1ec74f
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature4_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.14e-05	193	156	6	72d20ee257149b238016b44d183ce3fc24b8f621
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C DHH	6.14e-05	193	156	6	6a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.32e-05	194	156	6	2e3a64bda7c76fd0c99e93de0215f236e8045d83
ToppCell	15-Airway-Endothelial\|Airway / Age, Tissue, Lineage and Cell class	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH	6.32e-05	194	156	6	ac0e48b0c09a7f57d30dff321b0c30a4c5e16ad9
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH	6.32e-05	194	156	6	8c88a0ddd61ad900426e312ca4ab13061c0380b8
ToppCell	15-Airway-Endothelial-Endothelial\|Airway / Age, Tissue, Lineage and Cell class	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH	6.32e-05	194	156	6	f3851337a2d17f4acef2cd812a766eb0b503748b
ToppCell	PCW_05-06-Epithelial\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DCDC2 GDF15 MAP7 CRH KRTCAP3 NECTIN4	6.32e-05	194	156	6	47a1369c22fcbfe00b08376eb610a61c355548db
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C DHH	6.32e-05	194	156	6	b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCell	PCW_05-06-Endothelial-Endothelial_mature\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH	6.50e-05	195	156	6	54fde2cfa51ab3a2d48d2426494ca6f0ce77f725
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAM15 PPP1R13B SOX18 CARD10 SHANK3 GDPD5	6.50e-05	195	156	6	f65053811074a7f2ff0368f3a63b88e2a08da1a0
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.50e-05	195	156	6	ca2cf2c10db1ad17aa0a2e30aa7079a7ad751ea6
ToppCell	PCW_07-8.5-Endothelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.50e-05	195	156	6	f2cc94d5e1652203ca38bea57f37d3deec73ef04
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NR2F6 GDF15 SREBF1 NECTIN4 FAM83A MSLN	6.50e-05	195	156	6	24d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCell	wk_08-11-Mesenchymal-Mesothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	APLP1 PRSS33 BRINP1 COL18A1 LRRN4 MSLN	6.50e-05	195	156	6	9016a44b521214546a55a822ebdef5b5312206d2
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.50e-05	195	156	6	c7abcb674e4a25a5354c4947fffd0d17bc8c1fab
ToppCell	PCW_13-14-Endothelial-Endothelial_mature\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 DHH	6.50e-05	195	156	6	31353269591c9eee84872838e91995d4a035da46
ToppCell	NS-moderate-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADAM15 MFSD4A KRTCAP3 NECTIN4 FAM83A MSLN	6.69e-05	196	156	6	70384c1da9baed843f414cfd1403ddd586a2db07
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C STARD9	6.69e-05	196	156	6	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	PCW_13-14-Endothelial\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.69e-05	196	156	6	7286de29a34e13834cd6347c67a1443897fa4ade
ToppCell	PCW_13-14-Endothelial-Endothelial_cycling-endo_proliferating1_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SH2D3C SOX18 CARD10 SHANK3 GDPD5	6.69e-05	196	156	6	b826dce5b3daa8eb3d4a530b9564de58d9ce3767
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.69e-05	196	156	6	29ed8b1c4cd730db8632fde6eece404f1883a86d
ToppCell	PCW_10-12-Endothelial-Endothelial_immature\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.69e-05	196	156	6	c65b8c7ea34a21897c390e6fb42ee8ca41e9c976
ToppCell	11.5-Airway-Endothelial-Endothelial\|Airway / Age, Tissue, Lineage and Cell class	ADAM15 SH2D3C SOX18 CARD10 SHANK3 GDPD5	6.69e-05	196	156	6	509ddea8d6e1d0b832f69490ab8a736af4ca19a8
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	DPY19L3 VASN ADAM15 SLC39A4 EML3 CHST2	6.69e-05	196	156	6	7be50b9156394dea44d7b8b476d4dd516abfafae
ToppCell	wk_08-11-Endothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 CTHRC1	6.69e-05	196	156	6	0e545874083fd8e954a49fc397d57a86b081008b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 SH2D3C SOX18 SHANK3 EVA1C STARD9	6.69e-05	196	156	6	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.69e-05	196	156	6	81278e696d823744267d6315c4d42799c4ea0b2c
ToppCell	PCW_13-14-Endothelial-Endothelial_immature\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.69e-05	196	156	6	9ed96085f0acce07bf2f8d4cc212cc50e613be0c
ToppCell	PCW_10-12-Endothelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM15 SOX18 CARD10 SHANK3 GDPD5 SLC22A10	6.69e-05	196	156	6	2c60dcf9132ee156f25b349e2ac5313709def4f6
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C5AR2 LRG1 COL18A1 DHH MICAL2 CTHRC1	6.69e-05	196	156	6	dbf154b3d166ffd07be717dac8d8a3350ac63e16
Drug	Diflorasone Diacetate [33564-31-7]; Down 200; 8uM; MCF7; HT_HG-U133A	NR2F6 C5AR2 PIDD1 AMBRA1 ZZEF1 EML3 FASTK SSH3 RERE	5.97e-06	196	149	9	2798_DN
Drug	Azacyclonol [115-46-8]; Down 200; 15uM; HL60; HG-U133A	PRPF31 NR2F6 MFHAS1 ADAM15 FBXL15 IRGQ MALT1 URB1 FASTK	6.48e-06	198	149	9	2020_DN
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	2.33e-05	2	143	2	DOID:0110471 (implicated_via_orthology)
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	1.39e-04	4	143	2	DOID:0060809 (implicated_via_orthology)
Disease	Intellectual Disability	KDM5C PEX6 LGI4 WDR26 SHANK3 PRR12 COL18A1 GNAS TBC1D23	3.46e-04	447	143	9	C3714756
Disease	intellectual disability (implicated_via_orthology)	IRS4 KDM5C UBR4 KDM5D	4.92e-04	75	143	4	DOID:1059 (implicated_via_orthology)
Disease	Profound Mental Retardation	KDM5C PEX6 SHANK3 COL18A1 GNAS	5.95e-04	139	143	5	C0020796
Disease	Mental Retardation, Psychosocial	KDM5C PEX6 SHANK3 COL18A1 GNAS	5.95e-04	139	143	5	C0025363
Disease	Mental deficiency	KDM5C PEX6 SHANK3 COL18A1 GNAS	5.95e-04	139	143	5	C0917816
Disease	Kartagener Syndrome	OFD1 DNAAF5 GAS2L2	6.51e-04	35	143	3	C0022521
Disease	Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	OFD1 DNAAF5 GAS2L2	6.51e-04	35	143	3	C4551906
Disease	Polynesian Bronchiectasis	OFD1 DNAAF5 GAS2L2	6.51e-04	35	143	3	C4317124
Disease	autism spectrum disorder (implicated_via_orthology)	KDM5C BRINP1 KDM5D SHANK3 CTNNB1	8.91e-04	152	143	5	DOID:0060041 (implicated_via_orthology)
Disease	obesity (is_implicated_in)	NCOA3 CYP27B1 CRH GNAS	1.02e-03	91	143	4	DOID:9970 (is_implicated_in)
Disease	Adrenal Gland Neoplasms	GNAS CTNNB1	1.25e-03	11	143	2	C0001624
Disease	Adrenal Cancer	GNAS CTNNB1	1.25e-03	11	143	2	C0750887
Disease	childhood trauma measurement, smoking behaviour measurement	ECT2 COL18A1 EHHADH	1.36e-03	45	143	3	EFO_0005671, EFO_0007979
Disease	Primary Ciliary Dyskinesia	OFD1 DNAAF5 GAS2L2	1.55e-03	47	143	3	C4551720
Disease	severe combined immunodeficiency (is_implicated_in)	RFX5 TAPBP	2.04e-03	14	143	2	DOID:627 (is_implicated_in)
Disease	bipolar disorder	DPY19L3 RNPEPL1 MACROD1 PPP1R13B BRINP1 DHH STARD9 GSDMA DLEC1	2.07e-03	577	143	9	MONDO_0004985
Disease	Carcinoma, Granular Cell	NCOA3 PTGER1 CTNNB1 MSLN	2.49e-03	116	143	4	C0205644
Disease	Adenocarcinoma, Tubular	NCOA3 PTGER1 CTNNB1 MSLN	2.49e-03	116	143	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	NCOA3 PTGER1 CTNNB1 MSLN	2.49e-03	116	143	4	C0205642
Disease	Carcinoma, Cribriform	NCOA3 PTGER1 CTNNB1 MSLN	2.49e-03	116	143	4	C0205643
Disease	Adenocarcinoma, Basal Cell	NCOA3 PTGER1 CTNNB1 MSLN	2.49e-03	116	143	4	C0205641
Disease	Adenocarcinoma	NCOA3 PTGER1 CTNNB1 MSLN	2.49e-03	116	143	4	C0001418
Disease	alcohol use disorder (implicated_via_orthology)	KDM5C SREBF1 KDM5D SSH3 SRRM2	2.66e-03	195	143	5	DOID:1574 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	2.68e-03	16	143	2	DOID:0050888 (implicated_via_orthology)
Disease	Multiple congenital anomalies	POLD1 CTNNB1	3.02e-03	17	143	2	C0000772
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B SRRM2	3.02e-03	17	143	2	DOID:0060307 (is_implicated_in)
Disease	Insulin Resistance	SREBF1 CTF1 GNAS	3.12e-03	60	143	3	C0021655
Disease	Insulin Sensitivity	SREBF1 CTF1 GNAS	3.12e-03	60	143	3	C0920563
Disease	Hemangiosarcoma	COL18A1 CTNNB1	3.39e-03	18	143	2	C0018923
Disease	Malignant Neoplasms	GNAS CTNNB1 ARHGAP45 MSLN	3.55e-03	128	143	4	C0006826
Disease	platelet component distribution width	MAGIX NPEPPS RNPEPL1 TTYH3 ZZEF1 COL18A1 BLOC1S3 DLEC1 GNAS CHST2	3.84e-03	755	143	10	EFO_0007984
Disease	response to ziprasidone	NOCT ZP4	4.18e-03	20	143	2	GO_0097337
Disease	kidney disease (biomarker_via_orthology)	SREBF1 TGFBR1	4.61e-03	21	143	2	DOID:557 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRLAPEEATALPLRR	GNAS	146	P84996
LPECLAPRLIRNLLD	CARD10	851	Q9BWT7
APRLIRNLLDLPSSR	CARD10	856	Q9BWT7
FLRPVPQLRVLDLTR	LRG1	111	P02750
RLRLDAAALAALPPL	CTF1	86	Q16619
LNPRAPRLLRRLEDA	CTF1	111	Q16619
PAASPQRLRGLLLLL	CTHRC1	6	Q96CG8
LLDIRDRINRLAPPV	BRINP1	696	O60477
ILELLQNRELVPGRP	ADAM15	81	Q13444
LARQLNPRGDLTPLD	GSDMA	11	Q96QA5
ALRILTAPRDLPLAR	GTPBP3	61	Q969Y2
ADPPQAERVLLALRR	APLP1	401	P51693
RPLPLVGNLHLLRLS	CYP2W1	36	Q8TAV3
LQRGDRLAVILPRIP	ACSM4	111	P0C7M7
LRPNLQPLSERLTLL	DPY19L3	231	Q6ZPD9
LLRPVALALPDLRQV	DNHD1	1821	Q96M86
LVDRPDLPRIRAQIL	AADACL3	206	Q5VUY0
RALLQSQPVRRTPLL	AMBRA1	226	Q9C0C7
LEALRRKLANAPRPL	PPP1R13B	691	Q96KQ4
QPQRFGRLLLRLPAL	NR2F6	346	P10588
GRLLLRLPALRAVPA	NR2F6	351	P10588
LPEARLRRVVGQLDP	QPCTL	76	Q9NXS2
QVNALVARLPLLLPR	RFX5	321	P48382
ELLIRPVQRLPSVAL	ECT2	591	Q9H8V3
LRLLNRLAQPAPELA	OFD1	466	O75665
LGELQRLLLDARPRP	CDC42BPG	1061	Q6DT37
RLQRPLPEDLAEALA	LRCH4	551	O75427
LAPLLLFRARPVQIA	LTN1	1386	O94822
VPLARPLRDALGALL	MON1B	251	Q7L1V2
AQPLPARALARLRAV	RADIL	361	Q96JH8
RALLRLAPLLLGNPQ	ANAPC1	1926	Q9H1A4
RLRSLLAPLLLRPQA	CYP27B1	136	O15528
LVCALEQERRLRLPP	FASTK	176	Q14296
PLREQGAIPRLVQLL	CTNNB1	526	P35222
RPPQFLLGLSEQLRR	INKA1	221	Q96EL1
LPREVRRAQARLLNP	NOP53	161	Q9NZM5
LRELLRDLPPENRAS	ARHGAP45	891	Q92619
PSARQLLARLDARPL	MAGIX	26	Q9H6Y5
LLNSPDRARRLQLSP	MAP7	206	Q14244
VLVLRRNRFARLPPA	MFHAS1	91	Q9Y4C4
LLAPPAGATLNRLRE	MALT1	21	Q9UDY8
PQRRPLLLSADELAL	MFSD4A	251	Q8N468
PLTRSLRLQLRDDAP	FER1L4	261	A9Z1Z3
LALLVALQRLPVRLP	KDM5D	1246	Q9BY66
ALQRLPVRLPEGEAL	KDM5D	1251	Q9BY66
RLHNALALIRLRNPP	EHHADH	6	Q08426
ASRLIPPLNQLELLR	KCNQ2	381	O43526
QAVLRQLLRLLPPRA	PTGER1	356	P34995
PPQLLVSRALLRLLA	PEX6	71	Q13608
QLQRPDVRLRTPLLH	COL18A1	251	P39060
RLLSFLGRQLEAPLP	MRS2	391	Q9HD23
AQINRIDPLAPLRLL	HERVK_113	326	P63132
PQPLLVGLRRRLSQR	LRRC75B	256	Q2VPJ9
GNATLLLNLRDPPRE	GDPD5	351	Q8WTR4
LLPRGAPERQRLLPA	MSLN	151	Q13421
PTRLQLEQLGLVPRL	FAM83A	406	Q86UY5
RRALAAQLPVLPRSE	FAHD2A	81	Q96GK7
LRRQLSLARPQAPAL	GDF15	141	Q99988
PRLSALPLRDRQDLA	KMT2B	891	Q9UMN6
DLALLQLRRPVPLSA	PRSS33	126	Q8NF86
LQQLLLPRRSLDSPA	CRH	116	P06850
LAPRPLREQLGKIRL	PRR35	431	P0CG20
DPLALAALPRRVQLQ	PROX2	281	Q3B8N5
LRRQVEPPGQLLRLF	EVA1C	21	P58658
LLRNLGPLDREAIDP	CDHR2	641	Q9BYE9
PRRLEPAHLAQLLLF	GRID2IP	926	A4D2P6
LRLRQFGPRVEALVP	LACTBL1	406	A8MY62
AIPRPNRLFLRQLRA	C2CD2L	281	O14523
PNSALLARALRAEPL	C5AR2	261	Q9P296
PTPVLLFLDRDLQRR	DHH	236	O43323
PARQPPKDRLLRAVL	GAS2L2	806	Q8NHY3
PGEPRQRRLLLLDLL	ANKRD9	221	Q96BM1
APAPARSLLQLRLAE	BLOC1S3	101	Q6QNY0
LAQLRAAGQLLVPPR	MACROD1	11	Q9BQ69
ILDRQLPRLPQLLSS	IFRD2	321	Q12894
LDSPLPLRQRLKLRF	GEN1	891	Q17RS7
ALAEALRLLRLQVPP	EML3	36	Q32P44
RDALPRLLPALAARL	DNAAF5	111	Q86Y56
LALPRIPNVRLALLQ	FKRP	91	Q9H9S5
IPNVRLALLQPALDR	FKRP	96	Q9H9S5
NLLLVRPLGPQASIR	B3GNT8	371	Q7Z7M8
LAQRPEPQLLRLRPS	DLEC1	71	Q9Y238
LLGVLQRLLPTRPDL	DHX34	291	Q14147
LPRLVAPARRLLEQG	POLD1	216	P28340
RDLSLPPVDRLGLQN	NPEPPS	606	P55786
NGDLINPASRLLIPR	DCDC2	146	Q9UHG0
ALLQRDAPGLRRLPA	NOCT	11	Q9UK39
ARLPPAERRRIFVLQ	CPHXL	81	A0A1W2PPM1
RLFQRRLLQLRAGPP	DENND2D	11	Q9H6A0
LRRALPPAQAGALLL	IRGQ	446	Q8WZA9
GLVALLASRNLLRPP	KRTCAP3	76	Q53RY4
LALAGNPLRALQPRA	LRRN4	151	Q8WUT4
IPARRLSPLVRLQEL	LINGO4	291	Q6UY18
PLRLIANAIRRSLEP	MICAL2	1531	O94851
PPRLLELAGQSLLRD	PRAMEF13	6	Q5VWM6
TRLDLRDNQLRDLPP	PIDD1	266	Q9HB75
LRRLAPALALPAPAL	PRSS56	421	P0CW18
RALFIVPRQRLDLLP	UPF2	606	Q9HAU5
SDLLRAIPRANPLSL	IRS4	976	O14654
LVLELCALRPAPRAL	RNPEPL1	61	Q9HAU8
LELLRRLGLIAVPPF	SLC35D3	56	Q5M8T2
TRDILLLPLQLPRAI	RIN1	151	Q13671
ELRRLEAALVKRPNP	SRRM2	41	Q9UQ35
ANLRTLENPEPLLRL	TCAF1	676	Q9Y4C2
PRNLRALSLGDQPLV	TOGARAM2	91	Q6ZUX3
LRLAPTQTLAPRRLL	LGI4	301	Q8N135
PPRLLELAGQSLLRD	PRAMEF14	6	Q5SWL7
ALLRISIPLDSNLRP	SLC22A10	71	Q63ZE4
GPQIPRAALARLLRD	FBXL15	71	Q9H469
LPRNDFPRIEGVLLL	HDHD5	181	Q9BXW7
PLLRRQLEGRLALPS	SPATA31A7	546	Q8IWB4
NRPLLRNSLDDLVGP	NCOA3	1026	Q9Y6Q9
LLNPEPRRLSPELRL	SLC39A4	481	Q6P5W5
RQPRLVALSEPALAL	SELENOO	91	Q9BVL4
ALALRLALLLARPPS	SHISA8	21	B8ZZ34
PSALELPQRLALNPR	CCT8L1P	6	A6NM43
PSALELPQRLALNPR	CCT8L2	6	Q96SF2
PLPLALPAVLRAQAR	SETD1B	1481	Q9UPS6
PPRLLELAGQSLLRD	PRAMEF1	6	O95521
LNPLERERLALAGPQ	RERE	1371	Q9P2R6
SLRDNRLAVLPPELA	SCRIB	341	Q14160
LARALPLQPRLERSS	STARD9	2206	Q9P2P6
PADIRLNPRRLPDLV	PRR12	1111	Q9ULL5
PPRLLELAGQSLLRD	PRAMEF2	6	O60811
ENIRRLLPLPPLENL	MROH2B	831	Q7Z745
PPLLQLFLDLLRRLV	URB1	951	O60287
PAQAVLLLGRLLPRH	STRC	1031	Q7RTU9
AAPRPRLLLLVLAAA	TGFBR1	6	P36897
IRLAAQLEAPRPPRL	SSH3	111	Q8TE77
RVLQESERPLPRAAL	SREBF1	906	P36956
PLPLAPEFIRNIRLL	BRINP2	111	Q9C0B6
RLLQAAPAAAPRALL	CHST2	16	Q9Y4C5
EPQLLRLLRSLPVAF	C11orf42	181	Q8N5U0
QLAQPTLRLPRTGRL	ATG4D	446	Q86TL0
PLLRRQLEGRLALPS	SPATA31A3	546	Q5VYP0
PARQLLAAILRASPR	PLK3	286	Q9H4B4
PLLRRQLEGRLALPS	SPATA31A1	546	Q5TZJ5
PLLRRQLEGRLALPS	SPATA31A5	546	Q5VU36
PSLRSLPHQLLLQRL	SHANK3	391	Q9BYB0
PAPRVRLGQDALLDL	TAPBP	166	O15533
LRNIIQGRPLPADLR	TBC1D23	36	Q9NUY8
RRDPRFPPQAELLLL	TMEM102	76	Q8N9M5
QSLPPDLRRKAARLV	PRPF31	281	Q8WWY3
LGLSRPLRPLRQLVE	PRRC2B	331	Q5JSZ5
QDNELRALPPLRLPR	VASN	156	Q6EMK4
LEPARLREAAAALLP	ZZEF1	51	O43149
RLPPAALRLARLEQL	TPBGL	186	P0DKB5
LLLSRLVAGALQPRP	PRR29	61	P0C7W0
LLIPRDNRPLEVGLL	SH2D3C	561	Q8N5H7
PAQAVLLLGRLLPRH	STRCP1	1031	A6NGW2
QARKARRLEPGLLLP	SOX18	161	P35713
RRRSLLNLTVADLPP	VSIG10L	481	Q86VR7
LPPRRLQTLLRQAVE	WDR26	296	Q9H7D7
RPALPFILRLLRGLA	UBR4	4716	Q5T4S7
RPEPLRAVQRLQGLL	TTYH3	161	Q9C0H2
PPLLLDSVRLALRND	ZP4	206	Q12836
RSNRVIELPLRPLLS	ULK3	226	Q6PHR2
LLHLQQDALPRPLRP	TLX2	231	O43763
RRLLEHVRLPLLAPA	KLHL35	236	Q6PF15
LLVALQRLPVRLPEG	KDM5C	1261	P41229
ARLEPAALGALPLLR	LRRC26	156	Q2I0M4
SFQARLRLRVLVPPL	NECTIN4	136	Q96NY8