Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetyl-CoA carboxylase activity	ACACB ACACA	9.53e-07	2	20	2	GO:0003989
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACB ACACA	1.43e-05	6	20	2	GO:0016421
GeneOntologyMolecularFunction	biotin binding	ACACB ACACA	1.43e-05	6	20	2	GO:0009374
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACB ACACA	2.00e-05	7	20	2	GO:0016885
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	BRCA1 NFAT5 KMT2D ZNF615	2.16e-03	566	20	4	GO:0001216
GeneOntologyBiologicalProcess	malonyl-CoA biosynthetic process	ACACB ACACA	6.39e-07	2	17	2	GO:2001295
GeneOntologyBiologicalProcess	malonyl-CoA metabolic process	ACACB ACACA	9.57e-06	6	17	2	GO:2001293
Domain	AcCoA_COase_cen	ACACB ACACA	1.09e-06	2	20	2	IPR013537
Domain	ACC_central	ACACB ACACA	1.09e-06	2	20	2	PF08326
Domain	Carboxyl_trans	ACACB ACACA	6.53e-06	4	20	2	PF01039
Domain	COA_CT_N	ACACB ACACA	6.53e-06	4	20	2	IPR011762
Domain	COA_CT_C	ACACB ACACA	6.53e-06	4	20	2	IPR011763
Domain	COA_CT_CTER	ACACB ACACA	6.53e-06	4	20	2	PS50989
Domain	Carboxyl_trans	ACACB ACACA	6.53e-06	4	20	2	IPR000022
Domain	COA_CT_NTER	ACACB ACACA	6.53e-06	4	20	2	PS50980
Domain	Biotin_COase_C	ACACB ACACA	1.09e-05	5	20	2	IPR005482
Domain	Biotin_BS	ACACB ACACA	1.09e-05	5	20	2	IPR001882
Domain	Biotin_carb_C	ACACB ACACA	1.09e-05	5	20	2	SM00878
Domain	Biotin_carb_C	ACACB ACACA	1.09e-05	5	20	2	PF02785
Domain	Biotin_carboxylation_dom	ACACB ACACA	1.09e-05	5	20	2	IPR011764
Domain	BIOTIN	ACACB ACACA	1.09e-05	5	20	2	PS00188
Domain	CPSASE_1	ACACB ACACA	1.09e-05	5	20	2	PS00866
Domain	BC	ACACB ACACA	1.09e-05	5	20	2	PS50979
Domain	Rudment_hybrid_motif	ACACB ACACA	1.63e-05	6	20	2	IPR011054
Domain	CPSASE_2	ACACB ACACA	1.63e-05	6	20	2	PS00867
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACB ACACA	2.28e-05	7	20	2	IPR005479
Domain	BC-like_N	ACACB ACACA	2.28e-05	7	20	2	IPR005481
Domain	Biotin_carb_N	ACACB ACACA	2.28e-05	7	20	2	PF00289
Domain	CPSase_L_D2	ACACB ACACA	2.28e-05	7	20	2	PF02786
Domain	Biotin_lipoyl	ACACB ACACA	3.90e-05	9	20	2	PF00364
Domain	Biotin_lipoyl	ACACB ACACA	4.88e-05	10	20	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACB ACACA	4.88e-05	10	20	2	PS50968
Domain	Single_hybrid_motif	ACACB ACACA	7.14e-05	12	20	2	IPR011053
Domain	-	ACACB ACACA	8.44e-05	13	20	2	3.40.50.20
Domain	ATP-grasp	ACACB ACACA	9.84e-05	14	20	2	IPR011761
Domain	PreATP-grasp_dom	ACACB ACACA	9.84e-05	14	20	2	IPR016185
Domain	ATP_GRASP	ACACB ACACA	9.84e-05	14	20	2	PS50975
Domain	-	ACACB ACACA	1.13e-04	15	20	2	3.30.1490.20
Domain	-	ACACB ACACA	1.65e-04	18	20	2	3.30.470.20
Domain	ATP_grasp_subdomain_1	ACACB ACACA	1.65e-04	18	20	2	IPR013815
Domain	-	ACACB ACACA	2.26e-04	21	20	2	3.90.226.10
Domain	ClpP/crotonase-like_dom	ACACB ACACA	2.26e-04	21	20	2	IPR029045
Domain	ATP_grasp_subdomain_2	ACACB ACACA	4.97e-04	31	20	2	IPR013816
Domain	UBA	NBR1 UBQLN1	6.72e-04	36	20	2	PF00627
Domain	UBA	NBR1 UBQLN1	1.00e-03	44	20	2	IPR015940
Domain	UBA	NBR1 UBQLN1	1.14e-03	47	20	2	PS50030
Domain	p53-like_TF_DNA-bd	NFAT5 TBR1	1.45e-03	53	20	2	IPR008967
Domain	UBA-like	NBR1 UBQLN1	2.11e-03	64	20	2	IPR009060
Domain	V-set	NECTIN4 VSIG10	1.63e-02	184	20	2	PF07686
Domain	ig	NECTIN4 VSIG10	1.73e-02	190	20	2	PF00047
Domain	Immunoglobulin	NECTIN4 VSIG10	1.73e-02	190	20	2	IPR013151
Pathway	REACTOME_CHREBP_ACTIVATES_METABOLIC_GENE_EXPRESSION	ACACB ACACA	2.19e-05	8	13	2	M26991
Pathway	WP_BIOTIN_METABOLISM_INCLUDING_IMDS	ACACB ACACA	2.82e-05	9	13	2	M40064
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACB ACACA	4.30e-05	11	13	2	M27086
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACB ACACA	4.30e-05	11	13	2	MM14764
Pathway	REACTOME_CARNITINE_METABOLISM	ACACB ACACA	7.10e-05	14	13	2	M27098
Pathway	REACTOME_CARNITINE_METABOLISM	ACACB ACACA	7.10e-05	14	13	2	MM14788
Pathway	WP_HEREDITARY_LEIOMYOMATOSIS_AND_RENAL_CELL_CARCINOMA_PATHWAY	ACACB ACACA	1.48e-04	20	13	2	M39751
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACACB ACACA	1.79e-04	22	13	2	M39440
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACACB ACACA	1.96e-04	23	13	2	MM15885
Pathway	KEGG_PROPANOATE_METABOLISM	ACACB ACACA	4.08e-04	33	13	2	M4086
Pathway	KEGG_PYRUVATE_METABOLISM	ACACB ACACA	6.00e-04	40	13	2	M7934
Pathway	REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP	ACACB ACACA	6.62e-04	42	13	2	M27172
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	ACACB ACACA	1.13e-03	55	13	2	M27001
Pathway	WP_AMPACTIVATED_PROTEIN_KINASE_SIGNALING	ACACB ACACA	1.68e-03	67	13	2	M39630
Pathway	REACTOME_SELECTIVE_AUTOPHAGY	NBR1 ARL13B	1.99e-03	73	13	2	MM15672
Pathway	WP_LEPTIN_SIGNALING	ACACB ACACA	2.15e-03	76	13	2	M39491
Pathway	WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS	ACACB ACACA	2.75e-03	86	13	2	M39375
Pathway	REACTOME_SELECTIVE_AUTOPHAGY	NBR1 ARL13B	3.00e-03	90	13	2	M29841
Pubmed	AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.	ACACB TBR1 ACACA	3.57e-08	12	20	3	21436046
Pubmed	De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.	ACACB ACACA	3.14e-07	2	20	2	25282359
Pubmed	Brca1 expression is regulated by a bidirectional promoter that is shared by the Nbr1 gene in mouse.	BRCA1 NBR1	3.14e-07	2	20	2	14729266
Pubmed	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	ACACB ACACA	3.14e-07	2	20	2	27693630
Pubmed	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.	ACACB ACACA	3.14e-07	2	20	2	32215608
Pubmed	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	ACACB ACACA	3.14e-07	2	20	2	29772612
Pubmed	Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.	ACACB ACACA	3.14e-07	2	20	2	29976587
Pubmed	BRCA1 is a novel regulator of metabolic function in skeletal muscle.	BRCA1 ACACA	3.14e-07	2	20	2	24565757
Pubmed	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.	ACACB ACACA	3.14e-07	2	20	2	24944901
Pubmed	Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1.	BRCA1 ACACA	3.14e-07	2	20	2	18452305
Pubmed	Structure and regulation of acetyl-CoA carboxylase genes of metazoa.	ACACB ACACA	3.14e-07	2	20	2	15749055
Pubmed	Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.	ACACB ACACA	3.14e-07	2	20	2	20139635
Pubmed	Sequence analysis of the rat Brca1 homolog and its promoter region.	BRCA1 NBR1	3.14e-07	2	20	2	9892727
Pubmed	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	ACACB ACACA	3.14e-07	2	20	2	28081256
Pubmed	Structural basis for regulation of human acetyl-CoA carboxylase.	BRCA1 ACACA	3.14e-07	2	20	2	29899443
Pubmed	Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.	ACACB ACACA	3.14e-07	2	20	2	26976583
Pubmed	BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains.	BRCA1 ACACA	3.14e-07	2	20	2	12360400
Pubmed	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.	ACACB ACACA	3.14e-07	2	20	2	29433631
Pubmed	Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex.	BRCA1 ACACA	3.14e-07	2	20	2	19061860
Pubmed	Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene.	BRCA1 NBR1	3.14e-07	2	20	2	8975707
Pubmed	Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.	ACACB ACACA	3.14e-07	2	20	2	36076520
Pubmed	AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.	ACACB ACACA	3.14e-07	2	20	2	25001074
Pubmed	ACCA phosphopeptide recognition by the BRCT repeats of BRCA1.	BRCA1 ACACA	3.14e-07	2	20	2	16698035
Pubmed	BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.	BRCA1 ACACA	3.14e-07	2	20	2	16326698
Pubmed	The subcellular localization of acetyl-CoA carboxylase 2.	ACACB ACACA	3.14e-07	2	20	2	10677481
Pubmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	ACACB ACACA	3.14e-07	2	20	2	28290443
Pubmed	Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.	ACACB ACACA	3.14e-07	2	20	2	30244972
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.	ACACB ACACA	3.14e-07	2	20	2	24338821
Pubmed	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	ACACB ACACA	9.42e-07	3	20	2	34668531
Pubmed	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.	ACACB ACACA	9.42e-07	3	20	2	30018077
Pubmed	Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.	ACACB ACACA	9.42e-07	3	20	2	19846279
Pubmed	Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.	ACACB ACACA	9.42e-07	3	20	2	18031993
Pubmed	The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21.	BRCA1 NBR1	9.42e-07	3	20	2	8700509
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACB ACACA	9.42e-07	3	20	2	28877461
Pubmed	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.	ACACB ACACA	9.42e-07	3	20	2	20457939
Pubmed	Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.	ACACB ACACA	9.42e-07	3	20	2	36417534
Pubmed	Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.	ACACB ACACA	9.42e-07	3	20	2	17521700
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACB ACACA	9.42e-07	3	20	2	18455495
Pubmed	Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.	ACACB ACACA	9.42e-07	3	20	2	31990961
Pubmed	The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.	ACACB ACACA	9.42e-07	3	20	2	27381369
Pubmed	Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.	ACACB ACACA	9.42e-07	3	20	2	17210641
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACB ACACA	9.42e-07	3	20	2	28768177
Pubmed	Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.	ACACB ACACA	1.88e-06	4	20	2	38447582
Pubmed	DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.	BRCA1 KMT2D	1.88e-06	4	20	2	25079327
Pubmed	Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.	ACACB ACACA	1.88e-06	4	20	2	24185692
Pubmed	Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.	BRCA1 NBR1	1.88e-06	4	20	2	20616007
Pubmed	Crystal structure of Spot 14, a modulator of fatty acid synthesis.	ACACB ACACA	1.88e-06	4	20	2	20952656
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	ACACB ACACA	3.14e-06	5	20	2	37163372
Pubmed	Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk.	BRCA1 ACACA	3.14e-06	5	20	2	30257991
Pubmed	Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.	ACACB ACACA	3.14e-06	5	20	2	32694673
Pubmed	TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.	ACACB ACACA	3.14e-06	5	20	2	16794074
Pubmed	Evaluation of selected binding domains for the analysis of ubiquitinated proteomes.	NBR1 UBQLN1	6.59e-06	7	20	2	23649778
Pubmed	Functional characterization of BRCA1 gene variants by mini-gene splicing assay.	BRCA1 NBR1	8.78e-06	8	20	2	24667779
Pubmed	The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations.	ACACB ACACA	8.78e-06	8	20	2	36001969
Pubmed	A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.	BRCA1 NBR1	1.13e-05	9	20	2	7545954
Pubmed	A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer.	BRCA1 NBR1	1.13e-05	9	20	2	21989022
Pubmed	SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.	ACACB ACACA	1.41e-05	10	20	2	19720090
Pubmed	SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing cortex.	TBR1 ARL13B	1.41e-05	10	20	2	25088364
Pubmed	The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.	TBR1 ARL13B	1.72e-05	11	20	2	31816041
Pubmed	HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.	ACACB ACACA	2.07e-05	12	20	2	21344388
Pubmed	LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis.	TBR1 ARL13B	2.44e-05	13	20	2	33510165
Pubmed	Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors.	BRCA1 TBR1	2.44e-05	13	20	2	19403657
Pubmed	Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.	TBR1 ARL13B	2.85e-05	14	20	2	27974163
Pubmed	Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.	BRCA1 TBR1	3.28e-05	15	20	2	27073218
Pubmed	YAP/TAZ maintain the proliferative capacity and structural organization of radial glial cells during brain development.	TBR1 ARL13B	3.28e-05	15	20	2	34419458
Pubmed	Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.	TBR1 ARL13B	3.28e-05	15	20	2	32097653
Pubmed	Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.	TBR1 ARL13B	3.28e-05	15	20	2	35379995
Pubmed	Role of BRCA1 in brain development.	BRCA1 TBR1	3.75e-05	16	20	2	24639535
Pubmed	Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.	TBR1 ARL13B	4.25e-05	17	20	2	34710087
Pubmed	Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.	TBR1 ARL13B	4.78e-05	18	20	2	23817546
Pubmed	Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival.	ZFHX3 TBR1	4.78e-05	18	20	2	38912572
Pubmed	Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B.	BRCA1 UBQLN1	4.78e-05	18	20	2	16712842
Pubmed	Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium.	TBR1 ARL13B	5.34e-05	19	20	2	32985705
Pubmed	APC sets the Wnt tone necessary for cerebral cortical progenitor development.	TBR1 ARL13B	5.34e-05	19	20	2	28916710
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	BRCA1 ACACB ZFHX3 ARL13B ACACA	6.45e-05	777	20	5	35844135
Pubmed	BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1.	BRCA1 NBR1	6.55e-05	21	20	2	11013085
Pubmed	AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.	ACACB ACACA	6.55e-05	21	20	2	19217427
Pubmed	HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development.	TBR1 ARL13B	6.55e-05	21	20	2	30709655
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	ACACB ACACA	7.21e-05	22	20	2	20965718
Pubmed	ATP-citrate lyase deficiency in the mouse.	ACACB ACACA	7.89e-05	23	20	2	14662765
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ACACB ZFHX3 KMT2D ACACA	8.56e-05	418	20	4	34709266
Pubmed	A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development.	TBR1 ARL13B	9.35e-05	25	20	2	32840212
Pubmed	VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling.	BRCA1 TBR1	1.09e-04	27	20	2	21737879
Pubmed	WWP2 is an E3 ubiquitin ligase for PTEN.	ACACB ACACA	1.26e-04	29	20	2	21532586
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	NFAT5 NBR1 ZFHX3 DNAH14 ZSWIM1 ACACA	1.41e-04	1489	20	6	28611215
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	ACACB RAVER2 ACACA	1.46e-04	180	20	3	35198878
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	NBR1 KMT2D TBC1D2	1.55e-04	184	20	3	32908313
Pubmed	The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor.	TBR1 ARL13B	1.64e-04	33	20	2	26071364
Pubmed	Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.	TBR1 ARL13B	1.64e-04	33	20	2	30914320
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	ACACB ACACA	1.74e-04	34	20	2	26378152
Pubmed	Inceptor counteracts insulin signalling in β-cells to control glycaemia.	ACACB ACACA	1.74e-04	34	20	2	33505018
Pubmed	Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.	ACACB UBQLN1 ACACA	2.05e-04	202	20	3	29540532
Pubmed	Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.	MCF2L2 ACACA	2.54e-04	41	20	2	19343720
Pubmed	Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.	ACACB ACACA	2.67e-04	42	20	2	26362536
Pubmed	Functional dissection of Rab GTPases involved in primary cilium formation.	ARL13B TBC1D2	2.80e-04	43	20	2	17646400
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	ACACB NBR1 ACACA	2.84e-04	226	20	3	31452512
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ACACB NBR1 ACACA	3.48e-04	242	20	3	34011540
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	NBR1 KMT2D UBQLN1 TBC1D2	3.50e-04	604	20	4	38803224
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	BRCA1 NBR1 UBQLN1 ACACA	3.59e-04	608	20	4	16713569
Pubmed	Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.	NBR1 UBQLN1	3.79e-04	50	20	2	31699778
Cytoband	17q21	BRCA1 ACACA	3.47e-04	63	20	2	17q21
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	NFAT5 ZFHX3	2.86e-03	183	20	2	chr16q22
Cytoband	Ensembl 112 genes in cytogenetic band chr12q24	ACACB VSIG10	1.39e-02	415	20	2	chr12q24
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	BRCA1 NBR1	1.78e-02	473	20	2	chr17q21
GeneFamily	Adenosine receptors\|V-set domain containing	NECTIN4 VSIG10	8.92e-03	163	16	2	590
ToppCell	severe_COVID-19-B_cell\|World / disease group, cell group and cell class (v2)	ACACB DNAH14 ZSWIM1	3.44e-05	143	20	3	28b0e168126a9fe60541dc12bfab385b7a0a2342
ToppCell	severe_COVID-19-B_cell\|severe_COVID-19 / disease group, cell group and cell class (v2)	ACACB DNAH14 ZSWIM1	3.52e-05	144	20	3	c7f696e55e2d959c58ec32640c71ef86ee25203c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col27a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DNAH14 TBR1 TBC1D2	4.30e-05	154	20	3	d22902d2922784583f7016453768ed05b14b965e
ToppCell	COVID-CD4-CD4_Treg\|COVID / Condition, Cell_class and T cell subcluster	NBR1 KMT2D RAVER2	4.72e-05	159	20	3	037cd97c41eb2f91fd3f69bbb3ffdfd6c0158410
ToppCell	10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3\|Liver / Manually curated celltypes from each tissue	ACACB VWDE DNAH14	5.09e-05	163	20	3	7f61483eeb1fde21843c6391468e13cb0cc2a89f
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	NBR1 ZNF615 MCF2L2	6.61e-05	178	20	3	8b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NBR1 ZNF615 MCF2L2	7.17e-05	183	20	3	f142b320023eef00b48d4820c46214c9794d37e7
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	NBR1 ZNF615 MCF2L2	7.41e-05	185	20	3	e06a784a297f357f3f8e761c24fa70722048ab42
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	BRCA1 NFAT5 VSIG10	7.53e-05	186	20	3	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	BRCA1 NFAT5 VSIG10	7.53e-05	186	20	3	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BRCA1 VWDE ZSWIM1	8.27e-05	192	20	3	c7bcebcb88a25b2c97d798120efa9d5958e7f798
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BRCA1 VWDE ZSWIM1	8.27e-05	192	20	3	930319cbd82b9e54864147ffcdc8bd0ea7b937be
Computational	Steroid hormone receptors and binding proteins.	ACACB ACACA	2.50e-04	26	10	2	MODULE_404
Drug	6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one	ACACB ACACA	1.10e-05	6	20	2	ctd:C438505
Drug	Finasteride [98319-26-7]; Up 200; 10.8uM; PC3; HT_HG-U133A	ACACB NFAT5 TBR1 MCF2L2	2.27e-05	195	20	4	4300_UP
Drug	Biotin	ACACB ACACA	2.63e-05	9	20	2	DB00121
Drug	isosteviol	ACACB ACACA	4.81e-05	12	20	2	ctd:C515747
Disease	muscular disease (implicated_via_orthology)	ACACB ACACA	4.36e-06	5	20	2	DOID:0080000 (implicated_via_orthology)
Disease	breast carcinoma (is_marker_for)	BRCA1 ZFHX3 KMT2D	1.19e-05	66	20	3	DOID:3459 (is_marker_for)
Disease	lung non-small cell carcinoma (is_implicated_in)	BRCA1 ZFHX3 KMT2D	1.10e-04	139	20	3	DOID:3908 (is_implicated_in)
Disease	fatty liver disease (implicated_via_orthology)	ACACB ACACA	2.01e-04	31	20	2	DOID:9452 (implicated_via_orthology)
Disease	breast cancer (is_marker_for)	BRCA1 ZFHX3 KMT2D	2.56e-04	185	20	3	DOID:1612 (is_marker_for)
Disease	esophagus squamous cell carcinoma (is_implicated_in)	BRCA1 KMT2D	4.25e-04	45	20	2	DOID:3748 (is_implicated_in)
Disease	Prostatic Neoplasms	BRCA1 ZFHX3 KMT2D TBC1D2	6.98e-04	616	20	4	C0033578
Disease	Malignant neoplasm of prostate	BRCA1 ZFHX3 KMT2D TBC1D2	6.98e-04	616	20	4	C0376358
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	ACACB ACACA	8.85e-04	65	20	2	DOID:0080208 (biomarker_via_orthology)
Disease	prostate cancer (is_implicated_in)	BRCA1 ZFHX3	2.83e-03	117	20	2	DOID:10283 (is_implicated_in)
Disease	tea consumption measurement	NFAT5 ZFHX3	3.42e-03	129	20	2	EFO_0010091
Disease	stomach cancer (is_marker_for)	BRCA1 KMT2D	4.13e-03	142	20	2	DOID:10534 (is_marker_for)
Disease	colorectal cancer (is_marker_for)	BRCA1 ZFHX3	5.02e-03	157	20	2	DOID:9256 (is_marker_for)
Disease	lung non-small cell carcinoma (is_marker_for)	BRCA1 ZFHX3	5.79e-03	169	20	2	DOID:3908 (is_marker_for)
Disease	heart failure	NFAT5 ZFHX3	6.90e-03	185	20	2	EFO_0003144
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	ACACB NFAT5	8.02e-03	200	20	2	EFO_0004611, EFO_0020945
Disease	post-traumatic stress disorder	VWDE TBC1D2	8.17e-03	202	20	2	EFO_0001358
Disease	Obesity	ACACB ZFHX3	8.40e-03	205	20	2	C0028754

Protein segments in the cluster

Peptide	Gene	Start	Entry
NNQLGGIQIMHNNGV	ACACA	1866	Q13085
QGQVNHNGQKNNEFG	ARL13B	301	Q3SXY8
LNGEQAQNAIQMFHQ	RAVER2	111	Q9HCJ3
QINKMRNGQHFCDVQ	IPP	26	Q9Y573
SNNQLGGVQIMHYNG	ACACB	1976	O00763
QQNNIKDQGNPQFEM	MCF2L2	956	Q86YR7
LFHNTAGGTMNQLQN	NFAT5	1421	O94916
QNGQVMNITNSGHEN	BRCA1	541	P38398
MQNNANGNLIQDDIG	DNAH14	2826	Q0VDD8
LTNNKGASNNNGQMV	TBR1	311	Q16650
AVKQGNQLQMQVHEG	NBR1	71	Q14596
VKQCHEQNMFGNIVN	ZNF615	101	Q8N8J6
EQNMFGNIVNQNKGH	ZNF615	106	Q8N8J6
FHDKNGMQIDQNFNN	VWDE	576	Q8N2E2
GHQQFIQQMLQALAG	UBQLN1	521	Q9UMX0
LVNGNIEQMGNGFQD	VSIG10	506	Q8N0Z9
MQQNSADKANFNQGL	ZSWIM1	286	Q9BR11
QNTMHNIRGNKQAQG	TBC1D2	216	Q9BYX2
QSDKHLNNMQNLQNG	ZFHX3	746	Q15911
QQQHQQQGSMAGLSH	KMT2D	3861	O14686
EGIKQAMNHFVQENG	NECTIN4	476	Q96NY8