Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	WRN CHD9 BTAF1 SMARCAD1 DHX9 HELB HFM1	9.90e-06	127	117	7	GO:0008094
GeneOntologyMolecularFunction	sodium:sulfate symporter activity	SLC13A4 SLC13A1	3.40e-05	2	117	2	GO:0015382
GeneOntologyMolecularFunction	helicase activity	WRN CHD9 BTAF1 SMARCAD1 DHX9 HELB HFM1	4.07e-05	158	117	7	GO:0004386
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	WRN CHD9 BTAF1 SMARCAD1 DHX9 HELB HFM1 NEIL3	1.57e-04	262	117	8	GO:0140097
GeneOntologyMolecularFunction	ATP-dependent activity	DNHD1 MYH1 ATP8A2 WRN CHD9 BTAF1 SMARCAD1 DHX9 HELB UBA6 HFM1 MORC3	2.60e-04	614	117	12	GO:0140657
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DOCK1 RASGRF1 MYCBP2 DENND6A WDR41 PREX1 RGL4	4.27e-04	231	117	7	GO:0005085
GeneOntologyMolecularFunction	DNA helicase activity	WRN DHX9 HELB HFM1	4.81e-04	62	117	4	GO:0003678
GeneOntologyMolecularFunction	RISC complex binding	AGO2 DHX9	5.03e-04	6	117	2	GO:1905172
Domain	Helicase_C	WRN CHD9 BTAF1 SMARCAD1 DHX9 HFM1	6.02e-05	107	118	6	PF00271
Domain	HELICc	WRN CHD9 BTAF1 SMARCAD1 DHX9 HFM1	6.02e-05	107	118	6	SM00490
Domain	Helicase_C	WRN CHD9 BTAF1 SMARCAD1 DHX9 HFM1	6.34e-05	108	118	6	IPR001650
Domain	HELICASE_CTER	WRN CHD9 BTAF1 SMARCAD1 DHX9 HFM1	6.67e-05	109	118	6	PS51194
Domain	HELICASE_ATP_BIND_1	WRN CHD9 BTAF1 SMARCAD1 DHX9 HFM1	6.67e-05	109	118	6	PS51192
Domain	DEXDc	WRN CHD9 BTAF1 SMARCAD1 DHX9 HFM1	6.67e-05	109	118	6	SM00487
Domain	Helicase_ATP-bd	WRN CHD9 BTAF1 SMARCAD1 DHX9 HFM1	7.02e-05	110	118	6	IPR014001
Domain	ARM-type_fold	DOCK1 BTAF1 USP9Y URB1 ELMO3 LTN1 UTP20 SERAC1 PRKDC	3.03e-04	339	118	9	IPR016024
Domain	Na/sul_symport	SLC13A4 SLC13A1	3.91e-04	5	118	2	IPR001898
Domain	Na_sulph_symp	SLC13A4 SLC13A1	3.91e-04	5	118	2	PF00939
Domain	Pentatricopeptide_repeat	PRKDC GNAS PRORP	3.97e-04	23	118	3	IPR002885
Domain	WD40_repeat_CS	WDR31 EML6 SEC31B TBL1XR1 WDR41 WDSUB1	6.13e-04	164	118	6	IPR019775
Pathway	REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION	CHD9 TBL1XR1 F7 NAMPT	1.85e-05	27	84	4	M26943
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	NUP50 AGO2 NUP98 NUP155	1.00e-04	41	84	4	MM15200
Pathway	REACTOME_GENE_SILENCING_BY_RNA	NUP50 AGO2 NUP98 NUP155	2.03e-04	49	84	4	MM14837
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	NUP50 LEMD3 NUP98 NUP155	2.75e-04	53	84	4	M27212
Pathway	REACTOME_SODIUM_COUPLED_SULPHATE_DI_AND_TRI_CARBOXYLATE_TRANSPORTERS	SLC13A4 SLC13A1	3.47e-04	5	84	2	MM15099
Pathway	REACTOME_SODIUM_COUPLED_SULPHATE_DI_AND_TRI_CARBOXYLATE_TRANSPORTERS	SLC13A4 SLC13A1	3.47e-04	5	84	2	M27354
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGB1_TO_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	DOCK1 ELMO3	3.47e-04	5	84	2	M48982
Pathway	REACTOME_EXTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F7 TFPI	3.47e-04	5	84	2	M26948
Pathway	REACTOME_EXTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F7 TFPI	3.47e-04	5	84	2	MM14556
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK1 WRN BTAF1 DHX9 MYOF LTN1 UTP20 PRKDC	5.79e-07	202	121	8	33005030
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PNKD SH2B1 MYOF SH3GLB1 LTN1 ADAMTS16 APPL1 PHF14 MORC3 PRORP PREX1	1.31e-06	493	121	11	15368895
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MYCBP2 KDM5C ZMYND8 NUP98 BTAF1 SMARCAD1 DHX9 MYOF MTAP UTP20 APPL1 PHF14 PRKDC	3.21e-06	774	121	13	15302935
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	NUP50 LEMD3 NUP98 NUP155 PRKDC	7.59e-06	77	121	5	24927568
Pubmed	Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.	WRN DHX9 PRKDC	8.83e-06	12	121	3	21679440
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	NUP98 DCTN1 NAMPT NUP155 UTP20 APPL1 GNAS	9.93e-06	212	121	7	33462405
Pubmed	Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.	PRKDC ALOX15	1.20e-05	2	121	2	23437231
Pubmed	Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex.	KDM5C ZMYND8	1.20e-05	2	121	2	27058665
Pubmed	Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis.	MYOF APPL1	1.20e-05	2	121	2	35984564
Pubmed	Global analysis of AGO2-bound RNAs reveals that miRNAs induce cleavage of target RNAs with limited complementarity.	AGO2 PRKDC	1.20e-05	2	121	2	29031931
Pubmed	The SCID mouse: an experimental model for endometriosis.	MKKS PRKDC	1.20e-05	2	121	2	10601104
Pubmed	Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.	WRN PRKDC	1.20e-05	2	121	2	11889123
Pubmed	Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively--coincidence within one family.	LEMD3 EXT1	1.20e-05	2	121	2	20618940
Pubmed	Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks.	WRN PRKDC	1.20e-05	2	121	2	24429382
Pubmed	15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.	PRKDC ALOX15	1.20e-05	2	121	2	18785202
Pubmed	Epidermal dendritic cell populations in the flaky skin mutant mouse.	TTC7A PRKDC	1.20e-05	2	121	2	8406628
Pubmed	Mutual alteration of NOD2-associated Blau syndrome and IFNγR1 deficiency.	NOD2 IFNGR1	1.20e-05	2	121	2	31760574
Pubmed	Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit.	F7 TFPI	1.20e-05	2	121	2	10021455
Pubmed	Daily and circadian rhythms of tissue factor pathway inhibitor and factor VII activity.	F7 TFPI	1.20e-05	2	121	2	15604416
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	NUP50 KDM5C ZMYND8 NUP98 CHD9 SMARCAD1 TBL1XR1 DHX9 NAMPT NUP155 MEPCE UBA6 PHF14 PRKDC	1.23e-05	1014	121	14	32416067
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MYCBP2 FNDC3A TTC7A MYOF URB1 APPL1 PREX1	1.46e-05	225	121	7	12168954
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	DOCK1 NRAP BTAF1 SEC31B PPIF BTBD16 MYOF LIPA TMEM26	1.57e-05	415	121	9	16385451
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	AGO2 MYCBP2 LEMD3 KDM5C LTN1 MEPCE GNAS	2.33e-05	242	121	7	34011540
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	KDM5C NUP98 DHX9 NUP155 RRN3 LTN1 HFM1	2.87e-05	250	121	7	33536335
Pubmed	Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics.	NUP50 NUP98	3.59e-05	3	121	2	24943837
Pubmed	The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration.	LGR5 NOD2	3.59e-05	3	121	2	24882705
Pubmed	Study of factor VII, tissue factor pathway inhibitor and monocyte tissue factor in noninsulin-dependent diabetes mellitus.	F7 TFPI	3.59e-05	3	121	2	18180609
Pubmed	IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells.	IFNGR1 PRKDC	3.59e-05	3	121	2	22865049
Pubmed	Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.	WRN DHX9	3.59e-05	3	121	2	15995249
Pubmed	Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists.	WRN PRKDC	3.59e-05	3	121	2	17764108
Pubmed	Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).	AGO2 DHX9	3.59e-05	3	121	2	23361462
Pubmed	Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9.	NUP98 DHX9	3.59e-05	3	121	2	28221134
Pubmed	Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus.	PPIF IFNGR1	3.59e-05	3	121	2	35732121
Pubmed	A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages.	IFNGR1 NAMPT	3.59e-05	3	121	2	33976173
Pubmed	Tissue factor-dependent pathway in severe preeclampsia revisited: a Brazilian cohort study.	F7 TFPI	3.59e-05	3	121	2	26765308
Pubmed	Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome.	WRN DHX9	3.59e-05	3	121	2	17498979
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	STRBP ZMYND8 FNDC3A SMARCAD1 DCTN1 TBL1XR1 DHX9 NAMPT LTN1 UTP20 PRKDC	3.68e-05	704	121	11	29955894
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MYCBP2 TRPM7 ZMYND8 CHD9 SMARCAD1 GRIN2B USP9Y SEC31B DCTN1 SH2B1 SULF1 APPL1 PRKDC MORC3 PREX1	4.16e-05	1285	121	15	35914814
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	STRBP KDM5C ZMYND8 NUP98 BTAF1 SMARCAD1 DCTN1 TBL1XR1 SH2B1 NDUFV1 SLMAP UTP20	4.66e-05	857	121	12	25609649
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MYCBP2 TRPM7 LEMD3 FNDC3A SMARCAD1 EMC8 DCTN1 NDUFV1 DMXL1 DHX9 URB1 NUP155 SLMAP UBA6 WDR41 GNAS	5.98e-05	1487	121	16	33957083
Pubmed	The functional interactome landscape of the human histone deacetylase family.	NUP50 MYCBP2 ZMYND8 NUP98 TBL1XR1 APPL1 PRKDC	7.16e-05	289	121	7	23752268
Pubmed	Regulation of coagulation by a multivalent Kunitz-type inhibitor.	F7 TFPI	7.17e-05	4	121	2	2271516
Pubmed	Suppressive Role of Tissue Factor Pathway Inhibitor-α in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength.	F7 TFPI	7.17e-05	4	121	2	29452445
Pubmed	The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability.	ZMYND8 LGR5	7.17e-05	4	121	2	33932349
Pubmed	A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.	LIPA MTAP	7.17e-05	4	121	2	21606135
Pubmed	Structural and functional analysis of mRNA export regulation by the nuclear pore complex.	NUP98 NUP155	7.17e-05	4	121	2	29899397
Pubmed	Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis.	IFNGR1 PRKDC	7.17e-05	4	121	2	26831100
Pubmed	Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor.	F7 TFPI	7.17e-05	4	121	2	12787023
Pubmed	CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.	DOCK1 ELMO3	7.17e-05	4	121	2	11595183
Pubmed	Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation.	LGR5 NOD2	7.17e-05	4	121	2	31919280
Pubmed	Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth.	LGR5 PRKDC	7.17e-05	4	121	2	27109869
Pubmed	RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.	IFNGR1 GZMA	7.17e-05	4	121	2	28207896
Pubmed	CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.	AGO2 DHX9	7.17e-05	4	121	2	19955415
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MYCBP2 LEMD3 POMGNT1 TMTC2 EXT1 EMC8 LRRC8D DMXL1 TFPI IFNGR1 MYOF LTN1 RNFT1 UTP20	7.74e-05	1201	121	14	35696571
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TRPM7 LEMD3 WRN NUP98 DMXL1 DHX9 DENND6A NUP155 ADAMTS16 PRKDC WDR41	8.88e-05	777	121	11	35844135
Pubmed	Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.	NUP50 NUP98 NUP155	8.93e-05	25	121	3	10601273
Pubmed	Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.	NUP50 NUP98 NUP155	1.01e-04	26	121	3	12228227
Pubmed	Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis.	CYP26A1 STRA6	1.19e-04	5	121	2	18093970
Pubmed	Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.	IFNGR1 PRKDC	1.19e-04	5	121	2	30433869
Pubmed	Tissue factor pathway inhibitor and the revised theory of coagulation.	F7 TFPI	1.19e-04	5	121	2	7598447
Pubmed	Conditional gene targeting on the pure C57BL/6 genetic background.	GRIN2B KCNH5	1.19e-04	5	121	2	17298852
Pubmed	Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters.	SLC13A4 SLC13A1	1.19e-04	5	121	2	16211368
Pubmed	RNA helicase A interacts with RISC in human cells and functions in RISC loading.	AGO2 DHX9	1.19e-04	5	121	2	17531811
Pubmed	Inhibition of tissue factor:factor VIIa-catalyzed factor IX and factor X activation by TFPI and TFPI constructs.	F7 TFPI	1.19e-04	5	121	2	25163770
Pubmed	Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30.	IFNGR1 PRKDC	1.19e-04	5	121	2	22407920
Pubmed	Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system.	IFNGR1 PRKDC	1.19e-04	5	121	2	17376910
Pubmed	Fibroblast fusion to the muscle fiber regulates myotendinous junction formation.	MYH1 LOXL3	1.19e-04	5	121	2	34158500
Pubmed	Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway.	GRIN2B APPL1	1.19e-04	5	121	2	22933778
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DNHD1 NUP50 NUP98 SMARCAD1 EMC8 DCTN1 NDUFV1 DHX9 URB1 NAMPT NUP155 UBA6 UTP20 PRKDC GNAS	1.32e-04	1425	121	15	30948266
Pubmed	Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.	ZMYND8 SMARCAD1 PNKD TTC7A	1.47e-04	76	121	4	10574461
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	AGO2 MYCBP2 DMXL1 PRKDC	1.47e-04	76	121	4	27542412
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	KDM5C EML6 ZMYND8 DCTN1 MYOF LIPA PRKDC	1.69e-04	332	121	7	37433992
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	NUP50 AGO2 NUP98 ZCCHC3 URB1 UTP20 PHF14	1.69e-04	332	121	7	25693804
Pubmed	BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.	NUP98 DHX9 NUP155	1.72e-04	31	121	3	23086144
Pubmed	Architecture of the linker-scaffold in the nuclear pore.	NUP98 NUP155	1.78e-04	6	121	2	35679425
Pubmed	Fetal loss and hyposulfataemia in pregnant NaS1 transporter null mice.	SLC13A4 SLC13A1	1.78e-04	6	121	2	21403420
Pubmed	saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.	AGO2 DHX9	1.78e-04	6	121	2	26902284
Pubmed	Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II.	DHX9 PRKDC	1.78e-04	6	121	2	15613478
Pubmed	TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.	NUP98 TLR6	1.78e-04	6	121	2	32652111
Pubmed	Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche.	LGR5 PRKDC	1.78e-04	6	121	2	23467088
Pubmed	DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner.	DHX9 PRKDC	1.78e-04	6	121	2	14704337
Pubmed	Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.	GRIN2B UTP20	1.78e-04	6	121	2	20197096
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	WRN NUP98 TBL1XR1 NUP155 PRKDC	1.97e-04	152	121	5	28192407
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK1 BTAF1 SMARCAD1 SEC31B DCTN1 DHX9 NUP155 PRKDC GNAS	2.08e-04	582	121	9	20467437
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	MYCBP2 TRPM7 LEMD3 NUP98 FNDC3A EMC8 NDUFV1 ZCCHC3 PPIF DHX9 NUP155 SLMAP WDR41 GNAS PRORP	2.23e-04	1496	121	15	32877691
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	TRPM7 LEMD3 NUP98 FNDC3A EMC8 LRRC8D NUP155 WDR41	2.42e-04	468	121	8	31056421
Pubmed	Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy.	IFNGR1 PRKDC	2.49e-04	7	121	2	10899912
Pubmed	Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility.	IFNGR1 PRKDC	2.49e-04	7	121	2	34015257
Pubmed	Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling.	RASGRF1 GRIN2B	2.49e-04	7	121	2	20661302
Pubmed	Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.	LGR5 IFNGR1	2.49e-04	7	121	2	34529935
Pubmed	Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex.	NUP50 NUP98	2.49e-04	7	121	2	12802065
Pubmed	Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease.	TLR6 NOD2	2.49e-04	7	121	2	17595233
Pubmed	Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.	MYCBP2 LTN1	2.49e-04	7	121	2	36700049
Pubmed	Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.	NDUFV1 NUP155 PRKDC GNAS PTGDR2	2.50e-04	160	121	5	23798571
Pubmed	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	TLR6 NOD2 IFNGR1 PTGDR2	3.08e-04	92	121	4	19247692
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	MYCBP2 KDM5C DMXL1 GNAS	3.08e-04	92	121	4	15840729
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	NUP50 NUP98 NUP155	3.17e-04	38	121	3	12791264
Pubmed	Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin.	DHX9 PRKDC	3.32e-04	8	121	2	15723802
Pubmed	Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells.	RASGRF1 RGL4	3.32e-04	8	121	2	9154803
Pubmed	Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.	LGR5 PRKDC	3.32e-04	8	121	2	27989802
Cytoband	10q22-q23	BTAF1 PPIF	6.85e-05	5	121	2	10q22-q23
GeneFamily	WD repeat domain containing	WDR31 EML6 SEC31B TBL1XR1 DMXL1 WDR41 WDSUB1	1.87e-04	262	82	7	362
GeneFamily	Nucleoporins	NUP50 NUP98 NUP155	4.06e-04	32	82	3	1051
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DOCK1 AGO2 MYCBP2 ZMYND8 WRN NUP98 CHD9 FNDC3A EXT1 BTAF1 TFPI MYOF NAMPT MTAP LTN1 UTP20 PHF14	3.80e-07	856	120	17	M4500
Coexpression	GSE29618_PRE_VS_DAY7_POST_LAIV_FLU_VACCINE_PDC_DN	ZMYND8 BTAF1 AZI2 LRRC8D DMXL1 RRN3 LTN1 GNAS	3.75e-06	198	120	8	M5001
Coexpression	YAMAZAKI_TCEB3_TARGETS_UP	CYP26A1 FNDC3A EXT1 TFPI GNAS STRA6 UBE2Q2	1.17e-05	166	120	7	M1542
Coexpression	YAMAZAKI_TCEB3_TARGETS_UP	CYP26A1 FNDC3A EXT1 TFPI GNAS STRA6 UBE2Q2	1.91e-05	179	120	7	MM660
Coexpression	GSE28737_FOLLICULAR_VS_MARGINAL_ZONE_BCELL_BCL6_HET_UP	MYCBP2 EML6 HELB TTC7A IFNGR1 LIPA ALOX15	3.90e-05	200	120	7	M9354
Disease	Hemorrhagic Disorders	F7 GNAS	4.51e-05	3	115	2	C0019087
Disease	Kohlschutter-Tonz syndrome (implicated_via_orthology)	SLC13A4 SLC13A1	1.49e-04	5	115	2	DOID:0111668 (implicated_via_orthology)
Disease	alcohol-related neurodevelopmental disorder (implicated_via_orthology)	SLC13A4 SLC13A1	4.15e-04	8	115	2	DOID:0050667 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	GRIN2B DHX9 SLC13A4 SLC13A1 KCNH5	4.55e-04	163	115	5	DOID:1826 (implicated_via_orthology)
Disease	transient cerebral ischemia (is_implicated_in)	TFPI NAMPT	8.09e-04	11	115	2	DOID:224 (is_implicated_in)
Disease	schizophrenia (biomarker_via_orthology)	KDM5C GRIN2B	1.53e-03	15	115	2	DOID:5419 (biomarker_via_orthology)
Disease	infant head circumference	STRBP PREX1	1.53e-03	15	115	2	EFO_0004577
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C ZMYND8	1.74e-03	16	115	2	DOID:0050888 (implicated_via_orthology)
Disease	severe acute respiratory syndrome, COVID-19	ATP8A2 TCP11L1 WRN PHF14 WDR41 KIR2DS4 CFAP53	1.88e-03	447	115	7	EFO_0000694, MONDO_0100096
Disease	heart rate	ARSJ TFPI SLC13A1 NEIL3 UBE2Q2	1.92e-03	225	115	5	EFO_0004326
Disease	Profound Mental Retardation	KDM5C GRIN2B GNAS STRA6	2.18e-03	139	115	4	C0020796
Disease	Mental Retardation, Psychosocial	KDM5C GRIN2B GNAS STRA6	2.18e-03	139	115	4	C0025363
Disease	Mental deficiency	KDM5C GRIN2B GNAS STRA6	2.18e-03	139	115	4	C0917816
Disease	diabetes mellitus (biomarker_via_orthology)	F7 SLC22A12	2.47e-03	19	115	2	DOID:9351 (biomarker_via_orthology)
Disease	uric acid measurement	TRPM7 INSRR PNKD SLC22A12 CD160 MYOF HFM1 GNAS	2.72e-03	610	115	8	EFO_0004761
Disease	cognitive function measurement, self reported educational attainment	AGO2 MYCBP2 WRN BTAF1 SH2B1 PREX1	2.73e-03	355	115	6	EFO_0004784, EFO_0008354
Disease	diet measurement, body mass index	DOCK1 TBL1XR1	2.73e-03	20	115	2	EFO_0004340, EFO_0008111
Disease	Deaf Mutism	TMTC2 SERAC1	2.73e-03	20	115	2	C4082305
Disease	Deafness, Acquired	TMTC2 SERAC1	2.73e-03	20	115	2	C0751068
Disease	Hearing Loss, Extreme	TMTC2 SERAC1	2.73e-03	20	115	2	C0086395
Disease	Complete Hearing Loss	TMTC2 SERAC1	2.73e-03	20	115	2	C0581883
Disease	temporal lobe epilepsy (is_marker_for)	RASGRF1 GRIN2B	2.73e-03	20	115	2	DOID:3328 (is_marker_for)
Disease	Bilateral Deafness	TMTC2 SERAC1	2.73e-03	20	115	2	C3665473
Disease	Prelingual Deafness	TMTC2 SERAC1	2.73e-03	20	115	2	C0011052
Disease	autism spectrum disorder (implicated_via_orthology)	KDM5C CHD9 EXT1 PREX1	3.01e-03	152	115	4	DOID:0060041 (implicated_via_orthology)
Disease	Deep Vein Thrombosis	F7 TFPI	3.01e-03	21	115	2	C0149871
Disease	Venous Thrombosis	F7 TFPI	3.01e-03	21	115	2	C0042487
Disease	asthma (is_implicated_in)	TLR6 NOD2 IFNGR1 PTGDR2	3.37e-03	157	115	4	DOID:2841 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SNWEVEKLSCDLKIH	AZI2	156	Q9H6S1
DQAWEDTALHQKKLC	GNAS	86	P84996
LIWGDCVNSHAVVLK	ERVK11-1	106	P61568
TLLDCRKHLTWVVAV	DCTN1	826	Q14203
DVILECLGFKWELHQ	BTBD16	81	Q32M84
NLICTVWHKKEEAEG	CD160	41	O95971
TLKVELQNVLHCWEK	CCDC171	526	Q6TFL3
GALIAKDWVLTAAHC	GZMA	56	P12544
ISHWDKVKVLLNRIC	C8orf58	296	Q8NAV2
TKFCEVITLSWLQHL	ASB14	476	A6NK59
KSWHSICVLDSKEQP	DNHD1	21	Q96M86
SLDKTCHEIWKRVQG	C1orf94	61	Q6P1W5
HWLEKEVIALQRTCD	DMXL1	2061	Q9Y485
ACLIEDVAWRAAKHT	ATP8A2	1081	Q9NTI2
DHAILLTGLDICSWK	ADAMTS16	381	Q8TE57
SIKWVSCVSLQALHD	AGO2	131	Q9UKV8
AGDVKQLSEIVCLHW	ANKRD42	36	Q8N9B4
AALNCSVRDWIVKHV	NUP50	161	Q9UKX7
ANIWALKEEGCTHVI	MTAP	76	Q13126
QWHLAIQEAILEKCS	LEMD3	801	Q9Y2U8
TIEDCWLHVNAKKSV	LTN1	326	O94822
LEKHWKSVVSRSVCD	AP3M2	16	P53677
CEALWGHLKELDSQL	NUP98	1276	P52948
GHLVKSEETVILQCW	KIR2DS4	36	P43632
TAWDELKLTCQTALH	MKKS	381	Q9NPJ1
LSLWKCPHKNITAED	LOXL3	381	P58215
KSEEHWTCVVCTLIN	NEIL3	316	Q8TAT5
DVVLCLSLTKWVHLN	MEPCE	576	Q7L2J0
AEKISCIDQIWHKAC	NRAP	16	Q86VF7
NKGTVCKELVHITDW	ARSJ	366	Q5FYB0
KDHEEWICTINNISK	APPL1	361	Q9UKG1
IFWKETTLAHACANV	KCNH5	616	Q8NCM2
WIDKTVINDHICLTF	MORC3	51	Q14149
HKALCTEKLEQWLCE	LALBA	126	P00709
AIKDSLNVLTCWKDL	ALOX15	186	P16050
ILAEWKQKCEETHAE	MYH1	1456	P12882
ITFDHLCKETTIILW	METTL21EP	211	A6NDL7
AAAHKVCLVLWALAV	PTGDR2	146	Q9Y5Y4
KETDAGRWVHIVCAL	PHF14	396	O94880
ALALWKLLCEHQFTI	NUP155	791	O75694
CKLWENSLHVSKQLE	HFM1	921	A2PYH4
VEHWIKVARECLSLN	RGL4	296	Q8IZJ4
RLKAEWDQHNDCKIL	CFAP53	61	Q96M91
LHCEWATEEQLLKDK	CHD9	726	Q3L8U1
QCIKVWTEDSIAKPH	CASD1	146	Q96PB1
LLKWSEDVCVAHLTQ	DOCK1	1246	Q14185
DVVLLTTCKHGKDWQ	EXT1	291	Q16394
WAALQKECKAVTLAV	BTAF1	736	O14981
QLKDLVDNHASVWAC	CCNF	61	P41002
EKVNDHICEITWECL	FNDC3A	1056	Q9Y2H6
ALCEEDLLLWIQKHT	DENND6A	536	Q8IWF6
AAVLKEVCDAWSLTH	ELMO3	31	Q96BJ8
VEKNQELCHLSTIDW	INSRR	141	P14616
GCKDALQLLIEHSWE	CYP26A1	266	O43174
AAIHVWDTQTLKCLS	EML6	751	Q6ZMW3
LEVALTLIDSWCKDH	EMC8	71	O43402
EAFLADAKWILHNCI	ZMYND8	211	Q9ULU4
IVAKWNLVCDSHALK	SLC22A12	131	Q96S37
GVICLATSIEKWNLH	SLC13A1	91	Q9BZW2
GVICVAAAVEKWNLH	SLC13A4	91	Q9UKG4
WHLCVDVEKVLASIH	HELB	376	Q8NG08
DWIKLQISHEAAACI	DHX9	1086	Q08211
LHVWGVTTEKSKEVC	IFNGR1	221	P15260
CLHVKFTDVAEIPAW	LRRC8D	541	Q7L1W4
LENIWDCSMVKHIAL	LGR5	756	O75473
KTQHDLSSILVDVWC	NXF2	476	Q9GZY0
TVKSCLDLLVNWLHI	RRN3	421	Q9NYV6
EIVHKAFWDCLSVQL	TCP11L1	106	Q9NUJ3
ATEIIGAICKHLSWS	UTP20	1636	O75691
AQHVKAWVSDIQECL	SH2B1	361	Q9NRF2
IEDHECAVWLLLRKS	SERAC1	126	Q96JX3
IAIEKLWHTVAIATC	TIGD6	396	Q17RP2
LSTVCEKVWTLGLHQ	TMEM26	136	Q6ZUK4
EGVTLVAILCTHKHW	PNKD	161	Q8N490
GLSEDLIWHCKTLIQ	SMARCAD1	436	Q9H4L7
IWVVSAAHCFDKIKN	F7	246	P08709
SLWEISKQIEGHTIC	NDUFV1	411	P49821
TQLAKCLHIWDLDVR	POMGNT1	591	Q8WZA1
TLDEHLTCLLLWVKQ	PRAMEF25	161	A6NGN4
KWLEQVAATGVLLHC	PREX1	1366	Q8TCU6
HLENLLSKAECTKIW	SH3GLB1	41	Q9Y371
STVECALKHVSDWLD	STRBP	36	Q96SI9
HCVLEWQKKEISLAA	MYCBP2	156	O75592
ACEKIWGEDLRHLIV	NAMPT	286	P43490
CTETWSLNSLVKHLL	WRN	171	Q14191
ICTIKTDWLDGKHVV	PPIF	156	P30405
SVERLVECWAKCHQA	SEC31B	691	Q9NQW1
CHSSIDVAKSLLAWV	PRORP	151	O15091
EKWVAVADICRCLHN	RASGRF1	1111	Q13972
ALKTVDHCLNKEVWQ	URB1	466	O60287
LWDVDRGICIHTLTK	TBL1XR1	426	Q9BZK7
VVELVKHHLWALEVC	STRA6	351	Q9BX79
SEEIHKGDVKTCTWL	XIRP2	941	A4UGR9
KAVTIHDTEKCQAWD	UBA6	86	A0AVT1
IVSWKLDELHCQFLV	UBE2Q2	26	Q8WVN8
LCRTVISDHINKWKD	RNFT1	411	Q5M7Z0
VEDIVTWLKRHCDVL	ZCCHC3	266	Q9NUD5
HWGLLAECQTSEKAL	NOD2	686	Q9HC29
NVIWKSISAIHILFC	TMEM220	56	Q6QAJ8
KLRKEWNALETECHS	SLMAP	661	Q14BN4
LLKTVCDWRNLHTVA	TMTC2	301	Q8N394
HSVIVEKNRCWDIIA	FSBP	36	O95073
EKAWQTFIIDLLLHC	USP9Y	1311	O00507
KKVHALWASVCLLLN	TFPI	6	P10646
LNHIETTWKCLVRVF	TLR6	256	Q9Y2C9
KKQSCEGSWEDVLHL	UNC5A	536	Q6ZN44
VSLFEVLLKWCAHTN	PRKDC	291	P78527
CWSAVKLQLSDDKII	XKR3	321	Q5GH77
KVCIGSLRWLEEAEH	TTC7A	456	Q9ULT0
KAHERNVCDKWLISI	ZNF782	161	Q6ZMW2
LIATSSHDCKVKIWN	WDR31	296	Q8NA23
DCQVKIWIVSFTHIL	WDSUB1	211	Q8N9V3
WQCIEDTSGKLRIHK	SULF1	461	Q8IWU6
AVKVQCTWSEHDILK	TRPM7	1626	Q96QT4
TCSADHLIILWKNGE	WDR41	421	Q9HAD4
EDWLSAHSLKCQKLT	VWA3A	91	A6NCI4
LLTIAERWEEKAHLC	KDM5C	976	P41229
KWLGTHVCTHVILKE	LIPA	241	P38571
CIVAKKEHFWSIDQT	MYOF	1861	Q9NZM1
HTVWEKENVKLHCSI	MYOM1	286	P52179
ELEALWLTGICHNEK	GRIN2B	791	Q13224