Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	membrane lipid metabolic process	ST8SIA2 NOTUM NEU3 ABCC1 ALOX12B	1.93e-07	229	13	5	GO:0006643
GeneOntologyBiologicalProcess	sphingolipid metabolic process	ST8SIA2 NEU3 ABCC1 ALOX12B	3.45e-06	176	13	4	GO:0006665
GeneOntologyBiologicalProcess	ceramide metabolic process	ST8SIA2 NEU3 ALOX12B	4.40e-05	113	13	3	GO:0006672
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	ST8SIA2 ABCC1 ALOX12B	4.88e-05	117	13	3	GO:0030148
GeneOntologyBiologicalProcess	glycolipid metabolic process	ST8SIA2 NOTUM NEU3	5.13e-05	119	13	3	GO:0006664
GeneOntologyBiologicalProcess	liposaccharide metabolic process	ST8SIA2 NOTUM NEU3	5.26e-05	120	13	3	GO:1903509
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	ST8SIA2 ABCC1 ALOX12B	1.17e-04	157	13	3	GO:0046467
GeneOntologyBiologicalProcess	ganglioside metabolic process	ST8SIA2 NEU3	1.47e-04	29	13	2	GO:0001573
GeneOntologyBiologicalProcess	oligosaccharide metabolic process	ST8SIA2 NEU3	8.64e-04	70	13	2	GO:0009311
GeneOntologyBiologicalProcess	ceramide biosynthetic process	ST8SIA2 ALOX12B	9.40e-04	73	13	2	GO:0046513
GeneOntologyBiologicalProcess	glycosphingolipid metabolic process	ST8SIA2 NEU3	9.40e-04	73	13	2	GO:0006687
GeneOntologyBiologicalProcess	lipid biosynthetic process	ST8SIA2 ABCC1 ALOX12B TPTE2	1.29e-03	813	13	4	GO:0008610
GeneOntologyCellularComponent	recycling endosome	ST8SIA2 NEU3 SCAMP3 SCAMP4	8.21e-06	222	13	4	GO:0055037
GeneOntologyCellularComponent	recycling endosome membrane	NEU3 SCAMP3 SCAMP4	4.12e-05	112	13	3	GO:0055038
GeneOntologyCellularComponent	trans-Golgi network membrane	SCAMP3 SCAMP4	2.14e-03	112	13	2	GO:0032588
GeneOntologyCellularComponent	endosome	ST8SIA2 NEU3 SCAMP3 SCAMP4	4.60e-03	1167	13	4	GO:0005768
GeneOntologyCellularComponent	endosome membrane	NEU3 SCAMP3 SCAMP4	5.48e-03	602	13	3	GO:0010008
Domain	SCAMP	SCAMP3 SCAMP4	3.78e-06	5	12	2	IPR007273
Domain	SCAMP	SCAMP3 SCAMP4	3.78e-06	5	12	2	PF04144
Pathway	REACTOME_SIALIC_ACID_METABOLISM	ST8SIA2 NEU3	2.36e-04	33	10	2	MM15038
Pathway	REACTOME_SIALIC_ACID_METABOLISM	ST8SIA2 NEU3	2.36e-04	33	10	2	M27319
Pathway	REACTOME_METABOLISM_OF_LIPIDS	NEU3 ABCC1 ALOX12B TPTE2	6.29e-04	620	10	4	MM15193
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	ABCC1 ALOX12B	7.58e-04	59	10	2	M27140
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	ABCC1 ALOX12B	8.11e-04	61	10	2	MM14861
Pathway	REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS	ST8SIA2 NEU3	8.92e-04	64	10	2	M892
Pathway	REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN	ST8SIA2 NEU3	1.29e-03	77	10	2	MM15118
Pathway	REACTOME_METABOLISM_OF_LIPIDS	NEU3 ABCC1 ALOX12B TPTE2	1.34e-03	757	10	4	M27451
Pathway	REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN	ST8SIA2 NEU3	1.36e-03	79	10	2	M897
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	NEU3 ABCC1	1.83e-03	92	10	2	MM15086
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	NEU3 ABCC1	2.47e-03	107	10	2	M14857
Pathway	REACTOME_FATTY_ACID_METABOLISM	ABCC1 ALOX12B	6.11e-03	170	10	2	MM15573
Pathway	REACTOME_FATTY_ACID_METABOLISM	ABCC1 ALOX12B	6.53e-03	176	10	2	M27854
Pathway	REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION	ST8SIA2 NEU3	1.74e-02	293	10	2	MM15120
Pathway	REACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE	TMEM11 RP2	1.78e-02	297	10	2	M27050
Pathway	REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION	ST8SIA2 NEU3	1.90e-02	307	10	2	M894
Pubmed	Ubiquitously expressed secretory carrier membrane proteins (SCAMPs) 1-4 mark different pathways and exhibit limited constitutive trafficking to and from the cell surface.	SCAMP3 SCAMP4	1.29e-07	2	13	2	16105885
Pubmed	Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions.	SCAMP3 SCAMP4	1.29e-06	5	13	2	11050114
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	ABCC1 SCAMP3 RP2 SCAMP4	2.70e-05	499	13	4	22810586
Pubmed	Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation.	SCAMP3 SCAMP4	3.85e-05	25	13	2	15935055
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	ABCC1 SCAMP3 SCAMP4	1.82e-04	307	13	3	37499664
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	ABCC1 PRR35	6.26e-03	426	13	2	chr16p13
GeneFamily	Secretory carrier membrane proteins	SCAMP3 SCAMP4	1.71e-06	5	8	2	735
Coexpression	TABULA_MURIS_SENIS_AORTA_FIBROBLAST_OF_CARDIAC_TISSUE_AGEING	TMEM11 ABCC1 SCAMP3 RP2 SCAMP4	1.69e-05	723	13	5	MM3672
Drug	heptanesulfonic acid	ST8SIA2 RP2	1.08e-05	9	13	2	CID000089829
Drug	idarubicinol	ABCC1 RP2	3.15e-05	15	13	2	CID000107865
Drug	heptafluorobutyric acid	ST8SIA2 RP2	7.56e-05	23	13	2	CID000009777
Drug	AC1L1GZB	TMEM11 ABCC1 ALOX12B	1.05e-04	167	13	3	CID000003908
Drug	phenidone	TMEM11 ALOX12B	3.07e-04	46	13	2	CID000007090
Drug	NSC2801	NEU3 ABCC1	3.21e-04	47	13	2	CID000000471
Drug	PDMP	NEU3 ABCC1	6.52e-04	67	13	2	CID000114736
Drug	sodium glycocholate	NEU3 ABCC1	6.91e-04	69	13	2	CID000000755
Drug	AC1L1TSE	TMEM11 ABCC1	7.52e-04	72	13	2	CID000060719
Drug	sodium butyrate	ST8SIA2 NEU3 ABCC1	8.74e-04	344	13	3	CID005222465
Drug	L-663,536	ABCC1 ALOX12B	9.51e-04	81	13	2	CID000105049
Drug	hydroxyhydroquinone	NEU3 ABCC1	1.81e-03	112	13	2	ctd:C013038
Drug	TXB2 (thromboxane B2	TMEM11 ALOX12B	2.00e-03	118	13	2	CID000005461
Drug	NSC3364	ST8SIA2 NEU3	2.00e-03	118	13	2	CID000025439
Drug	thiobarbituric acid	NEU3 ALOX12B	2.00e-03	118	13	2	CID002723628
Drug	quercetin	ABCC1 ALOX12B TPTE2	2.30e-03	482	13	3	CID005280343
Drug	lactosylceramide	ST8SIA2 NEU3	2.80e-03	140	13	2	CID006450208
Drug	CMP-Neu5Ac	ST8SIA2 NEU3	2.84e-03	141	13	2	CID000000316
Disease	tetradecenoylcarnitine meaasurement	ABCC1 ALOX12B	5.37e-07	3	13	2	EFO_0021809
Disease	autism spectrum disorder (implicated_via_orthology)	SCAMP3 SCAMP4	1.98e-03	152	13	2	DOID:0060041 (implicated_via_orthology)
Disease	mean corpuscular hemoglobin concentration	ABCC1 TRIM34 PRR35	1.13e-02	1105	13	3	EFO_0004528

Protein segments in the cluster

Peptide	Gene	Start	Entry
FYFNPECLYVFPCQW	GXYLT2	321	A0PJZ3
WGKPYNYKCFQCPFT	PRR35	31	P0CG20
WNCFFGYKVYPTLRC	NOTUM	316	Q6P988
FFPKDPWYCNYVQIC	ALOX12B	76	O75342
PCSFVCWYRPMYKAF	SCAMP3	211	O14828
FTPCGYVCWFRPVYK	SCAMP4	81	Q969E2
VPCFYLWACFPFYFL	ABCC1	41	P33527
KCCFSQPVYPYFNPW	TRIM34	461	Q9BYJ4
FCKQIYLYGFWPFPL	ST8SIA2	306	Q92186
YYIPSWFFCFQLPCK	NEU3	181	Q9UQ49
LYGISWQFDPCCKYQ	TMEM11	121	P17152
GCFQWYYPELAFQFK	RP2	146	O75695
NLPKYYDNCPFFFWF	TPTE2	466	Q6XPS3