Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 VN1R17P MRGPRX4 OR5K2 OR2AK2 DRD3 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P GPR139 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2 OXGR1	3.74e-25	884	42	26	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	2.27e-24	431	42	21	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 VN1R17P MRGPRX4 OR5K2 OR2AK2 DRD3 OR7E24 OR14C36 PTPRB OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P GPR139 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2 OXGR1	7.81e-22	1353	42	27	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR5K4 OR5K2 OR14C36 OR14A16 OR10Q1	6.77e-06	127	42	5	GO:0005549
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	1.22e-24	432	42	21	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 VN1R17P OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	4.31e-24	547	42	22	GO:0007606
GeneOntologyBiologicalProcess	sensory perception of smell	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	5.76e-24	465	42	21	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	1.39e-23	485	42	21	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	7.04e-23	524	42	21	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	6.27e-22	582	42	21	GO:0050906
GeneOntologyBiologicalProcess	sensory perception	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 VN1R17P SLC45A2 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 GJB6 OR1J2 OR51I2 OR10Q1 OR2G2	1.70e-20	1072	42	24	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 VN1R17P MRGPRX4 OR5K2 OR2AK2 DRD3 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P GPR139 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2 OXGR1	1.78e-20	1395	42	26	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	5.41e-20	722	42	21	GO:0051606
Domain	GPCR_Rhodpsn_7TM	OR1E2 OR5K4 OR7G1 OR2J3 MRGPRX4 OR5K2 OR2AK2 DRD3 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 GPR139 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2 OXGR1	8.74e-24	670	39	23	IPR017452
Domain	7tm_1	OR1E2 OR5K4 OR7G1 OR2J3 MRGPRX4 OR5K2 OR2AK2 DRD3 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 GPR139 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2 OXGR1	1.11e-23	677	39	23	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR1E2 OR5K4 OR7G1 OR2J3 MRGPRX4 OR5K2 OR2AK2 DRD3 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 GPR139 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2 OXGR1	1.45e-23	685	39	23	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR1E2 OR5K4 OR7G1 OR2J3 MRGPRX4 OR5K2 OR2AK2 DRD3 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 GPR139 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2 OXGR1	1.77e-23	691	39	23	PS50262
Domain	GPCR_Rhodpsn	OR1E2 OR5K4 OR7G1 OR2J3 MRGPRX4 OR5K2 OR2AK2 DRD3 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 GPR139 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2 OXGR1	1.82e-23	692	39	23	IPR000276
Domain	Olfact_rcpt	OR1E2 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	4.19e-22	393	39	19	IPR000725
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	1.68e-21	417	37	20	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR7D2 OR1J2 OR51I2 OR10Q1 LRRC52 OR2G2	2.61e-19	636	37	21	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR1E2 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	6.38e-19	389	37	18	M14091
Pathway	WP_GPCRS_ODORANT	OR1E2 VN1R17P MRGPRX4 OR7E24 OR7A5 OR10H3 OR7A10 GPR139	5.81e-09	157	37	8	MM15872
Pathway	WP_GPCRS_OTHER	OR1E2 OR1P1 VN1R17P OR7E24 OR7A5 OR7A10	1.67e-07	96	37	6	MM15939
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	OR1E2 OR2J3 DRD3 OR7A5 OR10H3 OR7A10 OR1Q1	4.30e-06	260	37	7	M39397
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1E2 OR7G1 OR2J3 OR5K2	3.25e-05	70	37	4	MM14984
Pathway	REACTOME_SENSORY_PERCEPTION	OR1E2 OR7G1 OR2J3 OR5K2	1.49e-03	190	37	4	MM15687
Pubmed	The human olfactory receptor gene family.	OR1E2 OR1P1 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR14A16 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2 OR51I2 OR10Q1 OR2G2	1.82e-25	541	42	20	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR1Q1 OR4A47 OR4A4P OR51I2 OR10Q1	9.29e-24	340	42	17	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR1Q1 OR4A47 OR4A4P OR51I2 OR10Q1	9.29e-24	340	42	17	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR1Q1 OR4A47 OR4A4P OR51I2 OR10Q1	1.08e-23	343	42	17	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR1E2 OR1P1 OR5K4 OR7G1 OR2J3 OR5K2 OR2AK2 OR7E24 OR14C36 OR7A5 OR10H3 OR7A10 OR1Q1 OR4A47 OR4A4P OR51I2 OR10Q1	1.25e-23	346	42	17	14611657
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR1E2 OR1P1 OR7G1 OR2J3 OR7E24 OR7A5 OR7A10 OR1Q1 OR4A47 OR4A4P OR7D2 OR1J2	2.69e-17	219	42	12	12213199
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR1E2 OR7E24 OR7A5 OR7A10 OR1Q1	8.39e-11	24	42	5	9119360
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR2J3 OR7E24 OR7A10 OR14A16 OR7D2	2.65e-09	46	42	5	32126975
Pubmed	The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.	OR1E2 OR7A5 OR7A10 OR1J2	1.60e-08	23	42	4	10706615
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR1E2 OR7G1 OR2AK2 OR14C36 OR7A10	3.04e-08	74	42	5	15081110
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR1E2 OR7A5 OR7A10	4.64e-07	13	42	3	11014824
Pubmed	Expression of members of the putative olfactory receptor gene family in mammalian germ cells.	OR7A5 OR7D2 OR1J2	3.70e-06	25	42	3	1370859
Pubmed	Sestrin1 exerts a cytoprotective role against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by potentiating Nrf2 activation via the modulation of Keap1.	KEAP1 SESN1	4.27e-06	3	42	2	33069734
Pubmed	Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.	OR14C36 OR7A5 OR7A10	4.69e-06	27	42	3	32061665
Pubmed	Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome.	OR7E24 OR7A5	8.53e-06	4	42	2	9268701
Pubmed	Visualizing an olfactory sensory map.	OR7A5 OR7A10	2.13e-05	6	42	2	8929536
Pubmed	Identification of G protein-coupled receptor genes from the human genome sequence.	VN1R17P GPR139 OXGR1	2.40e-05	46	42	3	12044878
Pubmed	Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.	KEAP1 SESN1	3.97e-05	8	42	2	23274085
Pubmed	Identification of potential regulatory motifs in odorant receptor genes by analysis of promoter sequences.	OR1E2 OR1P1	3.97e-05	8	42	2	16902085
Pubmed	Identification of ligands for olfactory receptors by functional expression of a receptor library.	OR1P1 OR7A10	9.32e-05	12	42	2	9875846
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR1E2 OR7A10	1.28e-04	14	42	2	7528109
Pubmed	Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.	OR1E2 OR1P1	1.69e-04	16	42	2	10673334
Pubmed	Chromosomal location-dependent nonstochastic onset of odor receptor expression.	OR7A5 OR7A10	1.91e-04	17	42	2	20668191
Pubmed	Olfactory receptors and signalling elements in the Grueneberg ganglion.	OR1E2 OR7A10	1.91e-04	17	42	2	16805845
Pubmed	The DNA sequence and biology of human chromosome 19.	OR7E24 OR7A5 OR10H3 OR7A10	3.82e-04	284	42	4	15057824
Cytoband	1q44	VN1R17P OR2AK2 OR14C36 OR14A16 OR2G2	5.71e-08	110	42	5	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	VN1R17P OR2AK2 OR14C36 OR14A16 OR2G2	1.22e-07	128	42	5	chr1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	OR7G1 OR7E24 KEAP1 OR7A5 OR10H3 OR7A10 OR7D2	7.36e-06	797	42	7	chr19p13
Cytoband	19p13.2	OR7G1 OR7E24 KEAP1 OR7D2	5.82e-05	229	42	4	19p13.2
Cytoband	19p13.1	OR7A5 OR10H3	8.97e-04	48	42	2	19p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5K4 OR5K2	1.13e-03	54	42	2	chr3q11
Cytoband	17p13.3	OR1E2 OR1P1	2.98e-03	88	42	2	17p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	OR1Q1 OR1J2	7.14e-03	138	42	2	chr9q33
GeneFamily	Olfactory receptors, family 1	OR1E2 OR1P1 OR1Q1 OR1J2	9.08e-07	40	34	4	147
GeneFamily	Olfactory receptors, family 7	OR7G1 OR7E24 OR7A5 OR7A10 OR7D2	2.10e-06	113	34	5	154
GeneFamily	Olfactory receptors, family 14	OR14C36 OR14A16	7.17e-05	7	34	2	163
GeneFamily	Olfactory receptors, family 2	OR2J3 OR2AK2 OR2G2	1.24e-03	113	34	3	149
GeneFamily	Olfactory receptors, family 10	OR10H3 OR10Q1	6.83e-03	66	34	2	157
GeneFamily	G protein-coupled receptors, Class A orphans	MRGPRX4 GPR139	9.43e-03	78	34	2	262
GeneFamily	Olfactory receptors, family 5	OR5K4 OR5K2	1.88e-02	112	34	2	152
GeneFamily	Olfactory receptors, family 4	OR4A47 OR4A4P	2.44e-02	129	34	2	151
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-7\|TCGA-Brain / Sample_Type by Project: Shred V9	OR7E24 OR4A47 OR4A4P GPR139	6.71e-06	136	40	4	d94f0fbeb7b80d4cf0687d1924ebf8f9dd07358c
Disease	ureteral obstruction (biomarker_via_orthology)	KEAP1 GJB6	1.24e-03	45	34	2	DOID:5199 (biomarker_via_orthology)
Disease	obsolete aging	OR1E2 GPR139 OR51I2	4.03e-03	279	34	3	GO_0007568
Disease	visual epilepsy (biomarker_via_orthology)	DRD3 GJB6	4.84e-03	90	34	2	DOID:11832 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HPVYFCSTHYIEMLL	TBC1D32	1121	Q96NH3
VALIFTHCRLHTPMY	OR5K2	46	Q8NHB8
DRFVAICHPLHYMVI	OR7A5	121	Q15622
VRVCTHCYMFHVTPF	ZFYVE28	866	Q9HCC9
LHRVHMVQTECQYVY	PTPRB	1941	P23467
DRYVAICHPLHYTVI	OR1J2	121	Q8NGS2
DRYVAICHPLHYPML	OR2AK2	136	Q8NG84
YVAVCRPLHYTVLMH	OR2G2	126	Q8NGZ5
IPLRCTAHYVAYHVE	CPSF1	1016	Q10570
MAHDRYVAVCQPLHY	OR14C36	116	Q8NHC7
YVAICKPLHYLVIMR	OR4A47	121	Q6IF82
KHVPCYIHVLMSNVY	OR51I2	266	Q9H344
PLRYMCITHLDHKDY	LRRC52	231	Q8N7C0
MQHAVYVYDICHVII	TWNK	501	Q96RR1
HTPMYYFLCHLALVD	OR2I1P	56	Q8NGU4
LMVMGYDHYVTICHP	OR10H3	116	O60404
RYCVIIHPMSCFSIH	OXGR1	131	Q96P68
ICHPLRYTVLMNVHF	OR7G1	126	Q8NGA0
TPALLVAMHVAYYRH	GJB6	86	O95452
CVELHQRAREYIYMH	KEAP1	196	Q14145
YVKMCLHAARYPHAA	EMC9	11	Q9Y3B6
RYIAVCHPLKYHTVS	GPR139	126	Q6DWJ6
PMLHHILIFYAIVVC	GRAMD2B	341	Q96HH9
GCPYAYCRMHVTQLH	ERVFC1	106	P60507
VNMPPHYRYLCISHL	SLC45A2	311	Q9UMX9
IDRYTAVVMPVHYQH	DRD3	126	P35462
HRHALYLIIRMVCYD	ITGB1BP1	131	O14713
HYTAICFLLHYTAIM	OR1E2	131	P47887
HYTVVMHPCLYVLMA	OR2B8P	131	P59922
TMAYDRYVAICHLLH	OR1P1	131	Q8NH06
IMAYDRYVAICHPLH	OR10Q1	121	Q8NGQ4
RYVAICHPLHYTLIM	OR10Q1	126	Q8NGQ4
DRYIAICHPFHYTMI	OR1Q1	121	Q15612
YAAVCRPLHYTVLMH	OR2J3	126	O76001
YTAICHPLHYDVIMD	OR14A16	121	Q8NHC5
YVAICKPLHYLVIMR	OR4A4P	121	Q8NGN8
ICSPLLYNVIMSYHH	OR8G3P	126	P0DMU2
YRHYIGIMAAARHQC	SESN1	116	Q9Y6P5
MAYDRFVAICHPLHY	OR7E24	136	Q6IFN5
FVAICHPLHYRIIMN	OR7E24	141	Q6IFN5
DRFVAICHPLHYMVI	OR7A10	121	O76100
DRFVAVCHPLHYMII	OR7D2	121	Q96RA2
RMHLNLEVLYCHVYL	MRGPRX4	241	Q96LA9
DRYVAICHPLQYHTM	OR5K4	121	A6NMS3
CYLMAHVPFGHYTVK	SEC16B	566	Q96JE7
EHCYVLPMSYTHRSL	VN1R17P	171	Q8TDU5
VMSYLCCQYHIHEVP	SMC5	576	Q8IY18