Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR3	1.12e-04	4	87	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR3	2.78e-04	6	87	2	GO:0048763
GeneOntologyMolecularFunction	protein domain specific binding	PPP1R2 TCF12 UBR5 RAPGEF3 LRP2 ZNF521 PPP1R2P1 BCL2L1 LILRB1 KAT14 UNC13A STAMBP	4.00e-04	875	87	12	GO:0019904
GeneOntologyBiologicalProcess	cellular response to caffeine	SELENON RYR1 RYR3	1.17e-05	11	87	3	GO:0071313
GeneOntologyBiologicalProcess	cellular response to alkaloid	BCL2L1 SELENON RYR1 RYR3	2.40e-05	40	87	4	GO:0071312
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	SELENON RYR1 RYR3	2.55e-05	14	87	3	GO:0071415
GeneOntologyBiologicalProcess	leukocyte homeostasis	SH2B3 DOCK10 TNFRSF13B LILRB1 LILRB4 SOS2	4.65e-05	153	87	6	GO:0001776
GeneOntologyBiologicalProcess	B cell homeostasis	DOCK10 TNFRSF13B LILRB1 SOS2	4.99e-05	48	87	4	GO:0001782
GeneOntologyBiologicalProcess	response to caffeine	SELENON RYR1 RYR3	9.12e-05	21	87	3	GO:0031000
HumanPheno	Abnormal blood carbon dioxide level	MAP3K20 SELENON RYR1	2.83e-05	14	23	3	HP:0500164
HumanPheno	Hypercapnia	MAP3K20 SELENON RYR1	2.83e-05	14	23	3	HP:0012416
HumanPheno	Type 1 and type 2 muscle fiber minicore regions	SELENON RYR1	5.84e-05	3	23	2	HP:0003787
HumanPheno	Type 1 muscle fiber atrophy	MAP3K20 SELENON RYR1	6.28e-05	18	23	3	HP:0011807
HumanPheno	Abnormal blood gas level	MAP3K20 SELENON RYR1 ZFPM2	7.99e-05	53	23	4	HP:0012415
HumanPheno	Narrow face	NHS CEP152 GTF2IRD1 RYR1 RYR3	9.69e-05	108	23	5	HP:0000275
HumanPheno	Centrally nucleated skeletal muscle fibers	MAP3K20 SELENON RYR1 RYR3	1.30e-04	60	23	4	HP:0003687
HumanPheno	Abnormality of the forehead	TCF12 HECW2 KIAA0586 DOCK7 LRP2 PACS2 CEP152 GTF2IRD1 WNK3 RYR1 ZFPM2 RYR3 STAMBP SOS2	1.49e-04	1208	23	14	HP:0000290
HumanPheno	Type 1 muscle fiber predominance	MAP3K20 SELENON RYR1 RYR3	1.89e-04	66	23	4	HP:0003803
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5	1.42e-09	12	86	5	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5	1.42e-09	12	86	5	IPR027970
Domain	Ryanrecept_TM4-6	RYR1 RYR3	6.27e-05	3	86	2	IPR009460
Domain	RyR	RYR1 RYR3	6.27e-05	3	86	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR3	6.27e-05	3	86	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR3	6.27e-05	3	86	2	PF06459
Domain	Ryan_recept	RYR1 RYR3	6.27e-05	3	86	2	IPR013333
Domain	-	PRKD2 SH2B3 PLEKHM2 RANBP3 MTMR3 DOCK10 AKAP13 MPRIP SOS2	7.82e-05	391	86	9	2.30.29.30
Domain	PH	PRKD2 SH2B3 PLEKHM2 DOCK10 AKAP13 MPRIP SOS2	8.98e-05	229	86	7	PF00169
Domain	PH_dom-like	PRKD2 SH2B3 PLEKHM2 RANBP3 MTMR3 DOCK10 AKAP13 MPRIP SOS2	1.50e-04	426	86	9	IPR011993
Domain	PH	PRKD2 SH2B3 PLEKHM2 DOCK10 AKAP13 MPRIP SOS2	2.96e-04	278	86	7	SM00233
Domain	PH_DOMAIN	PRKD2 SH2B3 PLEKHM2 DOCK10 AKAP13 MPRIP SOS2	3.02e-04	279	86	7	PS50003
Domain	PH_domain	PRKD2 SH2B3 PLEKHM2 DOCK10 AKAP13 MPRIP SOS2	3.09e-04	280	86	7	IPR001849
Domain	DUF3398	DOCK7 DOCK10	3.11e-04	6	86	2	PF11878
Domain	RIH_assoc	RYR1 RYR3	3.11e-04	6	86	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR3	3.11e-04	6	86	2	IPR013662
Domain	RIH_dom	RYR1 RYR3	3.11e-04	6	86	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR3	3.11e-04	6	86	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR3	3.11e-04	6	86	2	IPR015925
Domain	-	RYR1 RYR3	3.11e-04	6	86	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR3	3.11e-04	6	86	2	PF01365
Domain	DOCK_C/D_N	DOCK7 DOCK10	3.11e-04	6	86	2	IPR021816
Domain	Ins145_P3_rec	RYR1 RYR3	3.11e-04	6	86	2	PF08709
Domain	MIR	RYR1 RYR3	9.21e-04	10	86	2	PS50919
Domain	MIR	RYR1 RYR3	9.21e-04	10	86	2	PF02815
Domain	MIR	RYR1 RYR3	9.21e-04	10	86	2	SM00472
Domain	MIR_motif	RYR1 RYR3	9.21e-04	10	86	2	IPR016093
Domain	DOCK_C	DOCK7 DOCK10	1.12e-03	11	86	2	IPR010703
Domain	DHR-1_domain	DOCK7 DOCK10	1.12e-03	11	86	2	IPR027007
Domain	DHR_2	DOCK7 DOCK10	1.12e-03	11	86	2	PS51651
Domain	DHR_1	DOCK7 DOCK10	1.12e-03	11	86	2	PS51650
Domain	DOCK-C2	DOCK7 DOCK10	1.12e-03	11	86	2	PF14429
Domain	DHR-2	DOCK7 DOCK10	1.12e-03	11	86	2	IPR027357
Domain	DHR-2	DOCK7 DOCK10	1.12e-03	11	86	2	PF06920
Domain	DOCK	DOCK7 DOCK10	1.12e-03	11	86	2	IPR026791
Domain	Ras_G-nucl-exch_fac_CS	RAPGEF3 SOS2	1.84e-03	14	86	2	IPR019804
Domain	CS_dom	PTGES3L USP19	2.41e-03	16	86	2	IPR007052
Domain	CS	PTGES3L USP19	2.41e-03	16	86	2	PS51203
Domain	ZF_DAG_PE_1	PRKD2 AKAP13 UNC13A	3.21e-03	64	86	3	PS00479
Domain	ZF_DAG_PE_2	PRKD2 AKAP13 UNC13A	3.21e-03	64	86	3	PS50081
Domain	C1	PRKD2 AKAP13 UNC13A	3.35e-03	65	86	3	SM00109
Domain	PE/DAG-bd	PRKD2 AKAP13 UNC13A	3.50e-03	66	86	3	IPR002219
Domain	RasGEFN	RAPGEF3 SOS2	3.77e-03	20	86	2	SM00229
Domain	RasGEF_N	RAPGEF3 SOS2	4.16e-03	21	86	2	PF00618
Domain	Ras-like_Gua-exchang_fac_N	RAPGEF3 SOS2	4.56e-03	22	86	2	IPR000651
Domain	RASGEF_NTER	RAPGEF3 SOS2	4.56e-03	22	86	2	PS50212
Domain	-	PTGES3L USP19	4.98e-03	23	86	2	2.60.40.790
Domain	RASGEF	RAPGEF3 SOS2	6.34e-03	26	86	2	PS00720
Domain	HSP20-like_chaperone	PTGES3L USP19	6.34e-03	26	86	2	IPR008978
Domain	HECT	UBR5 HECW2	6.83e-03	27	86	2	PF00632
Domain	HECTc	UBR5 HECW2	6.83e-03	27	86	2	SM00119
Domain	HECT_dom	UBR5 HECW2	6.83e-03	27	86	2	IPR000569
Domain	HECT	UBR5 HECW2	6.83e-03	27	86	2	PS50237
Domain	RASGEF_CAT	RAPGEF3 SOS2	7.85e-03	29	86	2	PS50009
Domain	RasGEF	RAPGEF3 SOS2	8.38e-03	30	86	2	PF00617
Domain	-	RAPGEF3 SOS2	8.38e-03	30	86	2	1.10.840.10
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5	2.37e-16	6	89	6	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5	2.37e-16	6	89	6	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5	3.07e-11	24	89	6	32212159
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIAA0513 UBR5 PLEKHM2 MTMR3 DOCK7 DOCK10 PACS2 ACIN1 FHIP2A USP15 PCDH10 USP19	5.92e-10	407	89	12	12693553
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	PPP1R2 KIAA1671 UBE2O UBR5 KIAA0586 DOCK7 NHS PFAS CEP152	3.61e-09	209	89	9	36779422
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRKD2 KIAA0930 SH2B3 NRF1 KIAA0513 PLEKHM2 MTMR3 PFAS AKAP13 GTF2IRD1 TEP1 MED13 RYR1 MPRIP RAB11FIP3	1.31e-07	1105	89	15	35748872
Pubmed	Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.	SELENON RYR1 RYR3	1.35e-06	9	89	3	21858002
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIAA1671 KIAA0930 RANBP3 MAP3K20 DOCK7 NHS AKAP13 CEP152 RNF180 WNK3 GOLGA4 MPRIP	2.03e-06	861	89	12	36931259
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	KIAA1671 WDR33 DDX42 DOCK7 DOCK10 AKAP13 EBNA1BP2 USP15 GOLGA4 GSPT1 MPRIP SOS2	3.83e-06	916	89	12	32203420
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	UBR5 PLEKHM2 CEP152 USP19 MPRIP	6.09e-06	100	89	5	10048485
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	KIAA1671 UBE2O KIAA0586 DOCK7 CEP152	6.39e-06	101	89	5	24613305
Pubmed	Leukocyte immunoglobulin-like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation.	LILRB1 LILRB4	6.48e-06	2	89	2	32918786
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	6.48e-06	2	89	2	12565913
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	6.48e-06	2	89	2	9489997
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	6.48e-06	2	89	2	9192302
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	6.48e-06	2	89	2	12640042
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	6.48e-06	2	89	2	7556644
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	6.48e-06	2	89	2	14592949
Pubmed	Multiminicore Disease – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	SELENON RYR1	6.48e-06	2	89	2	20301467
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	6.48e-06	2	89	2	15894801
Pubmed	Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle.	SELENON RYR1	6.48e-06	2	89	2	18713863
Pubmed	Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xL.	SH2B3 BCL2L1	6.48e-06	2	89	2	22101255
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	6.48e-06	2	89	2	9799464
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	6.48e-06	2	89	2	9817784
Pubmed	Renal Klotho safeguards platelet lifespan in advanced chronic kidney disease through restraining Bcl-xL ubiquitination and degradation.	UBE2O BCL2L1	6.48e-06	2	89	2	36087344
Pubmed	Plasmacytoid dendritic cells in patients with autoimmune thyroid disease.	LILRB1 LILRB4	6.48e-06	2	89	2	23666960
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	6.48e-06	2	89	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	6.48e-06	2	89	2	11500519
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KIAA0513 KIAA0586 PACS2 USP15 MED13	7.73e-06	105	89	5	9628581
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KIAA1671 UBE2O BRD8 WDR33 RANBP3 DOCK7 ACIN1 USP15 MPRIP	1.18e-05	549	89	9	38280479
Pubmed	Genome-wide association study of hematological and biochemical traits in a Japanese population.	SH2B3 DOCK7 LRP2 TNFRSF13B HIC2	1.26e-05	116	89	5	20139978
Pubmed	Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.	UBR5 MTMR3 DOCK7	1.29e-05	18	89	3	26598607
Pubmed	Human transcription factor protein interaction networks.	KIAA1671 UBE2O BRD8 TCF12 WDR33 LRP2 ZNF521 NHLH1 HIC2 CEP152 EBNA1BP2 KAT14 ZFPM2 MPRIP	1.57e-05	1429	89	14	35140242
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	PPP1R2 PRKD2 WDR33 ACIN1 NHS PFAS BCL2L1 UPF3A EBNA1BP2 USP15 MED13 GSPT1 MPRIP	1.70e-05	1247	89	13	27684187
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR3	1.94e-05	3	89	2	18403125
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	1.94e-05	3	89	2	11171121
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	1.94e-05	3	89	2	18313230
Pubmed	Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain.	BCL2L1 RYR3	1.94e-05	3	89	2	25872771
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR3	1.94e-05	3	89	2	18434746
Pubmed	Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4.	LILRB1 LILRB4	1.94e-05	3	89	2	10941837
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR3	1.94e-05	3	89	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR3	1.94e-05	3	89	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR3	1.94e-05	3	89	2	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR3	1.94e-05	3	89	2	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR3	1.94e-05	3	89	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR3	1.94e-05	3	89	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR3	1.94e-05	3	89	2	10788707
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR3	1.94e-05	3	89	2	25239916
Pubmed	Structural basis for regulation of protein phosphatase 1 by inhibitor-2.	PPP1R2 PPP1R2P1	1.94e-05	3	89	2	17636256
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR3	1.94e-05	3	89	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR3	1.94e-05	3	89	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR3	1.94e-05	3	89	2	11159936
Pubmed	USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression.	NRF1 USP15	1.94e-05	3	89	2	27416755
Pubmed	E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1.	RNF180 PCDH10	1.94e-05	3	89	2	37147733
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR3	1.94e-05	3	89	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR3	1.94e-05	3	89	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR3	1.94e-05	3	89	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR3	1.94e-05	3	89	2	7635066
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	PPP1R2 WDR33 DDX42 ACIN1 GSPT1	2.18e-05	130	89	5	35545047
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PPP1R2 KIAA0930 UBR5 WDR33 RANBP3 ACIN1 PFAS AKAP13 EBNA1BP2 EIPR1 USP15 UNC79 MPRIP	2.31e-05	1284	89	13	17353931
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	PPP1R2 UBR5 RANBP3 GTF2IRD1 USP15 GSPT1	2.61e-05	226	89	6	31452512
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	UBR5 DOCK7 PFAS AKAP13 SYBU GTF2IRD1	3.02e-05	232	89	6	25515538
Pubmed	OTUB1 modulates c-IAP1 stability to regulate signalling pathways.	UBR5 BIRC3 USP15	3.15e-05	24	89	3	23524849
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	3.87e-05	4	89	2	22100703
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR3	3.87e-05	4	89	2	18206662
Pubmed	Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex.	LILRB1 LILRB4	3.87e-05	4	89	2	11491530
Pubmed	Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences.	PPP1R2 PPP1R2P1	3.87e-05	4	89	2	7949733
Pubmed	The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.	BIRC3 USP19	3.87e-05	4	89	2	21849505
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR3	3.87e-05	4	89	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR3	3.87e-05	4	89	2	9384575
Pubmed	Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.	BIRC3 BCL2L1	3.87e-05	4	89	2	22403404
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR3	3.87e-05	4	89	2	9607712
Pubmed	Adenosine-induced caspase-3 activation by tuning Bcl-XL/DIABLO/IAP expression in HuH-7 human hepatoma cells.	BIRC3 BCL2L1	3.87e-05	4	89	2	20063052
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR3	3.87e-05	4	89	2	23482488
Pubmed	Calcium homeostasis in vascular smooth muscle cells is altered in type 2 diabetes by Bcl-2 protein modulation of InsP3R calcium release channels.	DOCK7 BCL2L1	3.87e-05	4	89	2	22037186
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	KIAA0930 MAP3K20 DOCK7 ACIN1 AKAP13 MPRIP	5.12e-05	255	89	6	15324660
Pubmed	HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells.	LILRB1 LILRB4	6.44e-05	5	89	2	15670976
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR3	6.44e-05	5	89	2	23918386
Pubmed	USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates.	USP15 GSPT1	6.44e-05	5	89	2	34583995
Pubmed	Regulators of the protein phosphatase PP1γ2, PPP1R2, PPP1R7, and PPP1R11 are involved in epididymal sperm maturation.	PPP1R2 PPP1R2P1	6.44e-05	5	89	2	30144392
Pubmed	Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin.	BIRC3 BCL2L1	6.44e-05	5	89	2	19763917
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR3	6.44e-05	5	89	2	19011160
Pubmed	Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor.	PPP1R2 PPP1R2P1	6.44e-05	5	89	2	26558779
Pubmed	IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.	BIRC3 BCL2L1	6.44e-05	5	89	2	18768389
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DDX47 PRKD2 UBE2O KIAA0586 DDX42 DOCK7 ACIN1 BIRC3 PFAS EBNA1BP2 GOLGA4 USP19 GSPT1	6.74e-05	1425	89	13	30948266
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR3	9.65e-05	6	89	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR3	9.65e-05	6	89	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR3	9.65e-05	6	89	2	23463619
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	RYR1 RYR3	9.65e-05	6	89	2	10444070
Pubmed	Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity.	PACS2 BIRC3	9.65e-05	6	89	2	24633224
Pubmed	The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.	BIRC3 GSPT1	9.65e-05	6	89	2	12865429
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR3	9.65e-05	6	89	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR3	9.65e-05	6	89	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR3	9.65e-05	6	89	2	25966694
Pubmed	Congenital Fiber-Type Disproportion – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	SELENON RYR1	9.65e-05	6	89	2	20301436
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR3	9.65e-05	6	89	2	19009018
Pubmed	Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.	LILRB1 LILRB4	9.65e-05	6	89	2	9079806
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR3	9.65e-05	6	89	2	16844763
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZSCAN29 DDX47 WDR33 DDX42 DOCK7 ZNF521 ACIN1 HIC2 UPF3A GTF2IRD1 UNC13A	1.00e-04	1082	89	11	38697112
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNB3 RYR1 RYR3	1.28e-04	38	89	3	30786075
Interaction	GSK3A interactions	PPP1R2 KIAA1671 UBE2O UBR5 WDR33 KIAA0586 DOCK7 ACIN1 NHS PFAS CEP152 BCL2L1 EBNA1BP2	8.16e-08	464	86	13	int:GSK3A
Interaction	GSK3B interactions	PPP1R2 KIAA1671 DDX47 UBE2O UBR5 HECW2 KIAA0586 DOCK7 NHS BIRC3 PFAS CEP152 BCL2L1 UPF3A	1.72e-05	868	86	14	int:GSK3B
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	1.03e-04	8	89	2	chr9q12
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PRKD2 SH2B3 PLEKHM2 DOCK10 AKAP13 MPRIP SOS2	1.70e-06	206	51	7	682
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR3	2.34e-05	3	51	2	287
GeneFamily	CD molecules\|Inhibitory leukocyte immunoglobulin like receptors	LILRB1 LILRB4	7.76e-05	5	51	2	1182
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF35 AKAP13 SOS2	8.54e-04	66	51	3	722
Coexpression	LAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM	KIAA1671 RAPGEF3 LRP2 ACIN1 NHS AKAP13 EBNA1BP2 GTF2IRD1 RAB11FIP3	1.03e-05	417	87	9	M39224
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	TCF12 LRP2 NHS AKAP13 GOLGA4 RAB11FIP3	2.26e-06	192	88	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	facs-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKD2 TCF12 XRRA1 BCL2L1 GTF2IRD1 MPRIP	2.48e-06	195	88	6	79114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCell	PND01-Immune-Immune_Myeloid-DC-cDC2\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCFD2 KIAA0930 TEP1 LILRB1 LILRB4	1.29e-05	152	88	5	cefc0ab592e99badf145fb95adf9906cb81be81c
ToppCell	PND01-Immune-Immune_Myeloid-DC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCFD2 KIAA0930 TEP1 LILRB1 LILRB4	1.29e-05	152	88	5	c8faa83dcaddb2ce2bb890f90dd8e676f7dcb1b3
ToppCell	PND01-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCFD2 KIAA0930 TEP1 LILRB1 LILRB4	1.29e-05	152	88	5	c3f00beb8b6fde99263d5ed6bbe3c2415d02f91d
ToppCell	droplet-Lung-3m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CMTM1 FOXR1 TNFRSF13B UNC79 RYR1	1.86e-05	164	88	5	cfe07a1ebed8aecb08d0476db71fe314998d54aa
ToppCell	droplet-Lung-3m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CMTM1 FOXR1 TNFRSF13B UNC79 RYR1	1.86e-05	164	88	5	6d331e74efecb4733d87653f86cd67247be05025
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel-D175\|Adult / Lineage, Cell type, age group and donor	KIAA1671 CACNB3 ZNF521 PFAS SELENON	2.68e-05	177	88	5	c9f269765c7d5d29caab75910e51645606ed562e
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CER1 FOXR1 DOCK10 CEP152 RYR1	2.75e-05	178	88	5	8c5e9fab7b55a654ccaabf2c4d02397399d94616
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DDX47 ARHGEF35 TNFRSF13B PACS2 RYR1	3.40e-05	186	88	5	74eb69a52090f9e2426a47e03a1c478ee0cfec18
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB3 RAPGEF3 BCL2L1 SYBU SOX8	3.66e-05	189	88	5	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SH2B3 DOCK10 LILRB1 RYR1 LILRB4	3.85e-05	191	88	5	baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SH2B3 DOCK10 LILRB1 RYR1 LILRB4	3.95e-05	192	88	5	86d792682ba51696f503c79625dd20f87bcf651f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SH2B3 DOCK10 LILRB1 RYR1 LILRB4	3.95e-05	192	88	5	d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 NHS GTF2IRD1 GOLGA4 RAB11FIP3	4.05e-05	193	88	5	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKD2 TCF12 XRRA1 BCL2L1 MPRIP	4.05e-05	193	88	5	a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SH2B3 DOCK10 LILRB1 RYR1 LILRB4	4.05e-05	193	88	5	f597fefc54327a1ad136e2f66b6e81cc5c761eb7
ToppCell	COVID-19_Severe-cDC\|COVID-19_Severe / disease group, cell group and cell class	KIAA0930 SH2B3 MAP3K20 RYR1 LILRB4	4.25e-05	195	88	5	6419090b19de7b5d5140eaecf231860273da2c0d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SH2B3 DOCK10 LILRB1 RYR1 LILRB4	4.57e-05	198	88	5	96883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCell	COVID-19_Severe-cDC\|World / disease group, cell group and cell class	KIAA0930 SH2B3 MAP3K20 RYR1 LILRB4	4.57e-05	198	88	5	c452334249f047265ae89dcabe7de446d968cae6
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SH2B3 DOCK10 LILRB1 RYR1 LILRB4	4.68e-05	199	88	5	744b63fba33b176ab7dde11646ccb313665505f7
Computational	Neighborhood of NF2	DDX47 WDR33 PACS2 BCL2L1 UPF3A USP19 GSPT1 STAMBP	1.55e-04	302	56	8	GCM_NF2
Computational	Neighborhood of MLL	DDX47 MTMR3 PACS2 UPF3A USP19 GSPT1	2.74e-04	174	56	6	GCM_MLL
Drug	NP-EGTA	RAPGEF3 ACIN1 RYR1 RYR3	1.60e-07	14	83	4	CID000183793
Drug	Glycopyrrolate [596-51-0]; Down 200; 10uM; PC3; HT_HG-U133A	CACNB3 KIAA0930 KIAA0513 WDR33 BIRC3 UPF3A RAB11FIP3 SOS2	6.17e-07	197	83	8	7386_DN
Drug	SR-95639A [115767-94-7]; Up 200; 10uM; MCF7; HT_HG-U133A	PLEKHM2 DOCK10 AKAP13 TEP1 UNC13A USP19 SOS2	8.03e-06	198	83	7	4977_UP
Drug	Ritodrine hydrochloride [23239-51-2]; Down 200; 12.4uM; HL60; HT_HG-U133A	NRF1 RANBP3 PACS2 UPF3A GTF2IRD1 LILRB1 SOS2	8.30e-06	199	83	7	1280_DN
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	1.31e-05	2	83	2	ctd:C005147
Drug	bimoclomol	AKAP13 RYR1 RYR3	1.65e-05	14	83	3	CID009576891
Drug	2-hydroxycarbazole	RYR1 RYR3	3.93e-05	3	83	2	CID000093551
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	3.93e-05	3	83	2	CID000080262
Drug	cis-diammineplatinum(II	RYR1 RYR3	3.93e-05	3	83	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR3	3.93e-05	3	83	2	CID002750949
Drug	flubendiamide	RYR1 RYR3	3.93e-05	3	83	2	CID011193251
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR3	3.93e-05	3	83	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR3	3.93e-05	3	83	2	CID000127713
Drug	aminodantrolene	RYR1 RYR3	3.93e-05	3	83	2	CID009570289
Drug	aescine	PRKD2 RAPGEF3 RYR1 RYR3	6.85e-05	60	83	4	CID004555259
Drug	HMS3267E16	BIRC3 AKAP13 RYR1 RYR3	7.80e-05	62	83	4	CID000003668
Drug	A-30	RYR1 RYR3	7.84e-05	4	83	2	CID003028528
Drug	PCB74	RYR1 RYR3	7.84e-05	4	83	2	CID000036218
Drug	148504-47-6	RYR1 RYR3	7.84e-05	4	83	2	CID006444275
Drug	Bastadin 10	RYR1 RYR3	7.84e-05	4	83	2	CID009589366
Drug	SC 38249	RYR1 RYR3	7.84e-05	4	83	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR3	7.84e-05	4	83	2	CID000035682
Drug	Sulfaphenazole [526-08-9]; Down 200; 12.8uM; PC3; HT_HG-U133A	KIAA0513 PLEKHM2 RANBP3 KIAA0586 BIRC3 AKAP13	8.21e-05	196	83	6	1794_DN
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	NRF1 RANBP3 LRP2 GSPT1 RAB11FIP3 SOS2	8.21e-05	196	83	6	5604_DN
Drug	Spectinomycin dihydrochloride [21736-83-4]; Down 200; 9.8uM; MCF7; HT_HG-U133A	KIAA0930 KIAA0586 MTMR3 USP19 RAB11FIP3 SOS2	8.21e-05	196	83	6	3327_DN
Drug	Epivincamine [6835-99-0]; Down 200; 11.2uM; PC3; HT_HG-U133A	CACNB3 NRF1 RANBP3 ZNF205 HIC2 SOS2	8.21e-05	196	83	6	4500_DN
Drug	Isoflupredone acetate [338-98-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	CACNB3 PLEKHM2 LRP2 ZNF205 AKAP13 RAB11FIP3	8.68e-05	198	83	6	5545_DN
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	KIAA0930 NRF1 KIAA0513 PLEKHM2 RANBP3 BIRC3	8.68e-05	198	83	6	7363_DN
Drug	Antipyrine [60-80-0]; Down 200; 21.2uM; MCF7; HT_HG-U133A	SH2B3 PLEKHM2 MAP3K20 MTMR3 ZNF205 BCL2L1	8.92e-05	199	83	6	1489_DN
Drug	AH6809; Up 200; 1uM; PC3; HT_HG-U133A	KIAA0930 KIAA0513 PLEKHM2 DOCK10 PACS2 UPF3A	8.92e-05	199	83	6	7075_UP
Drug	5707885; Down 200; 50uM; MCF7; HT_HG-U133A	ZNF205 AKAP13 HIC2 CEP152 RAB11FIP3 SOS2	8.92e-05	199	83	6	6433_DN
Drug	AC1L2AC7	CACNB3 LRP2 RYR1 RYR3	1.19e-04	69	83	4	CID000068733
Disease	platelet component distribution width	UBE2O BRD8 SH2B3 NRF1 RAPGEF3 DOCK7 DOCK10 PPP1R2P1 AKAP13 USP15 ZFPM2 MPRIP RAB11FIP3	1.38e-07	755	81	13	EFO_0007984
Disease	Multiminicore myopathy	SELENON RYR1	7.44e-06	2	81	2	cv:C0270962
Disease	Congenital Fiber Type Disproportion	MAP3K20 SELENON RYR1	1.58e-05	18	81	3	C0546264
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR3	2.23e-05	3	81	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR3	2.23e-05	3	81	2	DOID:8545 (implicated_via_orthology)
Disease	Rare disease with malignant hyperthermia	SELENON RYR1	4.45e-05	4	81	2	cv:C5681128
Disease	creatinine measurement	PRKD2 TCF12 NRF1 MTMR3 DOCK7 LRP2 EBNA1BP2 RYR1 OPLAH STAMBP SOS2	8.51e-05	995	81	11	EFO_0004518
Disease	Congenital myopathy with fiber type disproportion	SELENON RYR1	1.11e-04	6	81	2	cv:C0546264
Disease	Multiple Myeloma	TNFRSF13B BIRC3 BCL2L1	2.12e-04	42	81	3	C0026764
Disease	Congenital muscular dystrophy	SELENON RYR1	4.83e-04	12	81	2	cv:C0699743
Disease	Congenital myopathy (disorder)	SELENON RYR1	4.83e-04	12	81	2	C0270960
Disease	Autosomal Dominant Myotubular Myopathy	SELENON RYR1	5.69e-04	13	81	2	C3661489
Disease	Centronuclear myopathy	SELENON RYR1	5.69e-04	13	81	2	C0175709
Disease	X-linked centronuclear myopathy	SELENON RYR1	5.69e-04	13	81	2	C0410203
Disease	Congenital Structural Myopathy	SELENON RYR1	5.69e-04	13	81	2	C0752282
Disease	Myopathy, Centronuclear, 1	SELENON RYR1	5.69e-04	13	81	2	C4551952
Disease	C-X-C motif chemokine 11 measurement	SH2B3 ZFPM2	6.63e-04	14	81	2	EFO_0008057
Disease	Myopathy, Centronuclear, Autosomal Dominant	SELENON RYR1	6.63e-04	14	81	2	C1834558
Disease	Tubular Aggregate Myopathy	SELENON RYR1	6.63e-04	14	81	2	C0410207
Disease	tonsillectomy risk measurement	PPP1R2 PRKD2 SH2B3 MTMR3 TNFRSF13B	7.59e-04	260	81	5	EFO_0007924
Disease	matrix metalloproteinase 1 measurement	BIRC3 ZFPM2	7.64e-04	15	81	2	EFO_0010588
Disease	Autosomal Recessive Centronuclear Myopathy	SELENON RYR1	7.64e-04	15	81	2	C3645536
Disease	leukocyte immunoglobulin-like receptor subfamily B member 1 measurement	LILRB1 LILRB4	7.64e-04	15	81	2	EFO_0008208
Disease	cochlin measurement	NRF1 ZFPM2	8.71e-04	16	81	2	EFO_0801481
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	UBR5 BIRC3	8.71e-04	16	81	2	C0334634
Disease	serum IgG measurement	TNFRSF13B UNC13A	1.11e-03	18	81	2	EFO_0004565
Disease	wellbeing measurement, alcohol consumption measurement	KIAA0586 PCDH10 UNC13A	1.12e-03	74	81	3	EFO_0007869, EFO_0007878
Disease	COVID-19, mortality	SCFD2 KIAA0513 LRP2 EIPR1	1.25e-03	170	81	4	EFO_0004352, MONDO_0100096
Disease	bilirubin measurement	SH2B3 DDX42 MTMR3 DOCK7 TNFRSF13B SOS2	1.38e-03	442	81	6	EFO_0004570
Disease	sensory perception of sweet taste	ITGA11 AKAP13 PCDH10	1.51e-03	82	81	3	GO_0050916
Disease	cardiovascular disease	CER1 SH2B3 DOCK7 UPF3A ZFPM2 SOS2	1.63e-03	457	81	6	EFO_0000319
Disease	platelet measurement	TCF12 SH2B3 DOCK7 DOCK10 ZFPM2	1.77e-03	315	81	5	EFO_0005036
Disease	mean platelet volume	BRD8 TCF12 NRF1 DOCK7 DOCK10 TNFRSF13B ZFPM2 MPRIP RAB11FIP3	1.91e-03	1020	81	9	EFO_0004584
Disease	alcohol use disorder (implicated_via_orthology)	UNC79 UNC13A RYR1 RYR3	2.07e-03	195	81	4	DOID:1574 (implicated_via_orthology)
Disease	myeloproliferative disorder	SH2B3 ZNF521	2.14e-03	25	81	2	EFO_0004251

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPDEHSLQGSDMEDE	UNC13A	281	Q9UPW8
SAESEDEMIHPEGVA	ACIN1	166	Q9UKV3
MAAPEEHDSPTEASQ	DDX47	1	Q9H0S4
SPDPMAEAERTNGHS	AKAP2	121	Q9Y2D5
DLPHDMLDDDLSSPE	CEP152	36	O94986
EHSPLERDSLMPSDE	CACNB3	391	P54284
SEMDNEPPVSESDDG	BRD8	656	Q9H0E9
PTDMELSAHDDGAPA	AKAP13	1196	Q12802
MEAEEAQHGASPPIS	ARHGEF35	1	A5YM69
EAPEGTESEMETPSA	BCL2L1	36	Q07817
PGEDHSEDAIMMNTP	BIRC3	366	Q13489
EREMHPSRDSDSEPF	CER1	91	O95813
DMENAGHPSADTPTA	RANBP3	281	Q9H6Z4
PSECLDAMEEPDHGA	RAB11FIP3	351	O75154
ADSENDMGESPSHPS	KIAA0513	51	O60268
NMETSESPESHETPE	KIAA1107	701	Q9UPP5
PSDDEDMPGSHHDSQ	HECW2	351	Q9P2P5
EHMETNAVGPSPSSD	MPRIP	316	Q6WCQ1
HSSTDLESTDGMEGP	KIAA1671	1601	Q9BY89
GVEMDTRQSPHDEDP	LILRB4	341	Q8NHJ6
TASFDPPSDMDSEAE	GOLGA4	111	Q13439
PSTPYHSTMGDDEDA	PPP1R2P1	71	Q96PQ5
SSQDEDMGHFEIPDP	KIAA1109	4006	Q2LD37
DMGHFEIPDPMEEST	KIAA1109	4011	Q2LD37
LPRESDMEHSPSATE	ZFPM2	391	Q8WW38
DMEHSPSATEDSLQP	ZFPM2	396	Q8WW38
TEEDSSPASPMHERV	KIAA0930	271	Q6ICG6
PVDSDSDDDPLEAFM	DDX42	106	Q86XP3
MDTPPLSDSESESDE	EBNA1BP2	1	Q99848
PPQALFHDDDEMEGD	KAT14	361	Q9H8E8
SEEATEVHTMEGDPD	FAM153A	126	Q9UHL3
DENLHEPPSSDDMKS	TCF12	526	Q99081
SMLSADEDSPSSPED	NRF1	36	Q16656
MDESEDSGVIPGSHS	PRKD2	341	Q9BZL6
GDHSDEPIEECMSSA	LRP2	3661	P98164
EYSLEDPDHGPMLDD	ITGA11	751	Q9UKX5
SNLHVPGMDSVPDTE	PCDH10	971	Q9P2E7
DTLDMEHPSDSGPDM	PACS2	291	Q86VP3
EHPSDSGPDMEDDDS	PACS2	296	Q86VP3
MPKELESGSHESPDD	EIPR1	101	Q53HC9
SLGDGRPPEESAHEM	GSPT1	36	P15170
AKTMPEEDPATLDDH	HIDE1	181	A8MVS5
PSTPYHSMMGDDEDA	PPP1R2	71	P41236
THQEGEAVMPPLEDD	PPP4R3C	731	Q6ZMV5
MSPDGNHSSDPTEFV	OR6S1	1	Q8NH40
DTMELDLPPTHSETE	NHLH1	6	Q02575
PSESTQELHASDMPE	DOCK10	1126	Q96BY6
SAVPEESEMDPHVRD	DOCK7	101	Q96N67
EDQEDSSSMALPSPH	FOXR1	136	Q6PIV2
MPLHPETDSRASEED	MAP3K20	746	Q9NYL2
DAHDLGMPPAESQSL	KLF17	216	Q5JT82
DAESDLVDGRHSPPM	PRPSAP2	216	O60256
ATGMEQTELEDEPPH	FHIP2A	216	Q5W0V3
EEMTDSMPGHLPSED	GTF2IRD1	516	Q9UHL9
AGMPDPTSDEVHGEQ	RYR1	4381	P21817
SPDQPSRSHLDDDGM	MTMR3	1006	Q13615
SMPEASDQEEHLSPL	RNF180	341	Q86T96
DEGQGSPSEMVHSSE	PLEKHM2	571	Q8IWE5
TPDEPMDLEGAEDNH	HIC2	301	Q96JB3
IEDTVEMTDESSPHP	SOS2	261	Q07890
EMTDESSPHPLAGSC	SOS2	266	Q07890
PEDGVEMDTRSPHDE	LILRB1	541	Q8NHL6
EMDTRSPHDEDPQAV	LILRB1	546	Q8NHL6
SHPPEDEDTDVMLGQ	NHS	306	Q6T4R5
PDGASQSSHEPMEDA	SPATA31A6	131	Q5VVP1
PLEVSSEDHMDDGSP	OPLAH	981	O14841
MEGSLEEPQETSHSG	UPF3A	326	Q9H1J1
PDGASQSSHEPMEDA	SPATA31A7	131	Q8IWB4
PERPDSVDIEHMSSG	SCFD2	586	Q8WU76
SMSHVEDSDSDAPPS	SOX8	21	P57073
TQPHPDVSESTMDRD	MED13	1606	Q9UHV7
ASRSSHEPMEDAAPI	SPATA31C1	146	P0DKV0
MDPEHAKPESSEAPS	CMTM1	1	Q8IZ96
PDGASQSSHEPMEDA	SPATA31A3	131	Q5VYP0
LEAMGPDSSAHDPTE	RAPGEF3	401	O95398
MPHSPVSGDSVEEEE	USP19	471	O94966
MDSDASMDSEPTPHL	TEP1	2531	Q99973
PDGASQSSHEPMEDA	SPATA31A1	131	Q5TZJ5
PDGASQSSHEPMEDA	SPATA31A5	131	Q5VU36
SSLASPDESEPDSME	SYBU	516	Q9NX95
PDESEPDSMESFPES	SYBU	521	Q9NX95
PDPTQFGIHDDTMEA	RYR3	4236	Q15413
MSDHGDVSLPPEDRV	STAMBP	1	O95630
GSMEADHISKEAPEP	PFAS	431	O15067
SHDGSEEDVDTSEPM	ZNF521	871	Q96K83
EDGSMIDSHLPSGEP	SELENON	381	Q9NZV5
SPVEMQDEGAEEPHE	UBE2O	441	Q9C0C9
GSPSEMETDEPDDES	USP15	651	Q9Y4E8
ESTEAEMHIPSALEP	SH2B3	311	Q9UQQ2
DHAMEAGSPVSTSPE	TNFRSF13B	211	O14836
MEPEEPHSEGASQED	ZNF205	51	O95201
TSEHREMEAPGGPSE	WDR33	1241	Q9C0J8
SDSDDMDLEATPQDP	ZSCAN29	381	Q8IWY8
PPPAMDDLDDDSDSA	PTGES3L	146	E9PB15
VESEMPTENLEGHSP	XRRA1	501	Q6P2D8
HDAVEMEDDPPSEGQ	KIAA0586	1266	Q9BVV6
TASPEDSDMPDHDLE	UBR5	1306	O95071
LPEMSLDDHPDPGTE	UNC79	1756	Q9P2D8
LHEMSSDASLPGDPE	WNK3	1216	Q9BYP7
PSSPMSSDDESEIED	WNK3	1516	Q9BYP7