Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesskeratinization

LCE3D LCE2C LCE3E LCE2B

1.10e-0587334GO:0031424
GeneOntologyBiologicalProcessregulation of synaptic assembly at neuromuscular junction

MYCBP2 AGRN

5.19e-057332GO:0008582
GeneOntologyBiologicalProcessregulation of neuromuscular junction development

MYCBP2 AGRN

1.11e-0410332GO:1904396
GeneOntologyBiologicalProcesssynaptic assembly at neuromuscular junction

MYCBP2 AGRN

1.35e-0411332GO:0051124
GeneOntologyBiologicalProcessregulation of axon guidance

MYCBP2 AGRN

1.62e-0412332GO:1902667
GeneOntologyBiologicalProcesspositive regulation of non-canonical NF-kappaB signal transduction

TRIP6 EDA RBCK1

2.06e-0472333GO:1901224
GeneOntologyBiologicalProcesskeratinocyte differentiation

LCE3D LCE2C LCE3E LCE2B

2.27e-04189334GO:0030216
GeneOntologyBiologicalProcessskin development

EDA LCE3D LCE2C LCE3E LCE2B

2.95e-04373335GO:0043588
GeneOntologyBiologicalProcessregulation of chemotaxis

MST1L MYCBP2 AGRN MCU

5.79e-04242334GO:0050920
DomainLCE

LCE3D LCE2C LCE3E LCE2B

2.14e-0817344PF14672
DomainLCE

LCE3D LCE2C LCE3E LCE2B

2.14e-0817344IPR028205
DomainSPRR/LCE

LCE2C LCE3E LCE2B

1.75e-0528343IPR026075
Domain-

NHLH1 OLIG1 PTF1A

1.01e-031093434.10.280.10
DomainHLH

NHLH1 OLIG1 PTF1A

1.07e-03111343PF00010
DomainK_chnl_volt-dep_Kv

KCNA6 KCNC2

1.10e-0327342IPR003968
DomainHLH

NHLH1 OLIG1 PTF1A

1.21e-03116343SM00353
DomainBHLH

NHLH1 OLIG1 PTF1A

1.24e-03117343PS50888
DomainbHLH_dom

NHLH1 OLIG1 PTF1A

1.28e-03118343IPR011598
DomainVG_K_chnl

KCNA6 KCNC2

1.64e-0333342IPR028325
DomainBTB_2

KCNA6 KCNC2

4.18e-0353342PF02214
DomainT1-type_BTB

KCNA6 KCNC2

4.18e-0353342IPR003131
DomainChannel_four-helix_dom

KCNA6 KCNC2

4.82e-0357342IPR027359
Domain-

KCNA6 KCNC2

4.82e-03573421.20.120.350
DomainZF_BBOX

MYCBP2 RBCK1

9.30e-0380342PS50119
DomainZnf_B-box

MYCBP2 RBCK1

9.53e-0381342IPR000315
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT26 DSG3 LCE3D LCE2C LCE3E LCE2B

1.32e-07129276M27649
PathwayREACTOME_KERATINIZATION

KRT26 DSG3 LCE3D LCE2C LCE3E LCE2B

2.80e-06217276M27640
Pubmed

Rodent Lce gene clusters; new nomenclature, gene organization, and divergence of human and rodent genes.

LCE3D LCE2C LCE3E LCE2B

1.55e-091635417410201
Pubmed

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.

LCE3D LCE2C LCE3E LCE2B

6.20e-092235415854049
Pubmed

Differentially expressed late constituents of the epidermal cornified envelope.

LCE3D LCE2C LCE3E LCE2B

7.50e-092335411698679
Pubmed

Molecular cloning and characterization of a novel mouse epidermal differentiation gene and its promoter.

LCE3D LCE3E

5.90e-06435211350120
Pubmed

Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells.

LCE3D LCE3E

9.82e-06535211159194
Pubmed

Fate and plasticity of the epidermis in response to congenital activation of BRAF.

LCE3D LCE3E

7.62e-051335225202828
Pubmed

p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.

LCE3D LCE3E

1.17e-041635221930775
Pubmed

Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.

NHLH1 OLIG1 PTF1A

1.33e-049835318557763
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

MKRN4P ZFHX3 OLIG1 TRIP6 ZNF282 FIZ1

1.41e-0480835620412781
Pubmed

Repression by PRDM13 is critical for generating precision in neuronal identity.

OLIG1 PTF1A

1.85e-042035228850031
Pubmed

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.

LCE3D LCE3E

2.91e-042535223906066
Pubmed

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.

LCE3D LCE3E

2.91e-042535223132931
Pubmed

Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.

KCNA6 KCNC2

3.15e-04263527905852
Pubmed

Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium.

LCE3D LCE3E

3.15e-042635215454262
Pubmed

Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.

NHLH1 OLIG1

3.40e-042735224148613
Pubmed

Cdc42-mediated tubulogenesis controls cell specification.

PTF1A NOTCH4

3.66e-042835219914171
Pubmed

Assessment of community efforts to advance network-based prediction of protein-protein interactions.

KRT26 LCE3D LCE2C LCE3E LCE2B

3.97e-0463035536949045
Pubmed

TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer.

RAB18 RBCK1

4.20e-043035234285210
Pubmed

Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.

KCNA6 KCNC2

4.49e-04313528034307
Pubmed

Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.

LCE3D LCE3E

4.49e-043135220930145
Pubmed

The spatiotemporal expression pattern of Syndecans in murine embryonic teeth.

OLIG1 AGRN

5.41e-043435232220631
Pubmed

Olig3 regulates early cerebellar development.

OLIG1 PTF1A

7.49e-044035233591268
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNA6 KCNC2

7.49e-044035216382104
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZFHX3 TRIP6 SGPL1 UNC80 FIZ1 ZNF316

7.88e-04111635631753913
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

RPP25 MKRN4P ZFHX3 NOTCH4

8.46e-0442435421731673
InteractionRGS17 interactions

LCE3D LCE2C LCE3E LCE2B

1.40e-0648354int:RGS17
InteractionKRTAP1-5 interactions

LCE3D LCE2C LCE3E LCE2B

1.40e-0648354int:KRTAP1-5
InteractionHOXA1 interactions

TRIP6 LCE3D AGRN LCE2C RBCK1 LCE3E LCE2B

2.22e-06356357int:HOXA1
InteractionKRTAP5-2 interactions

LCE3D LCE2C LCE3E LCE2B

3.96e-0662354int:KRTAP5-2
InteractionKRTAP5-4 interactions

LCE3D LCE2C LCE3E LCE2B

4.22e-0663354int:KRTAP5-4
InteractionKRTAP5-3 interactions

LCE3D LCE2C LCE3E LCE2B

5.09e-0666354int:KRTAP5-3
InteractionLCE2A interactions

LCE3D LCE2C LCE3E LCE2B

6.08e-0669354int:LCE2A
InteractionKRTAP5-7 interactions

LCE3D LCE2C LCE3E LCE2B

6.82e-0671354int:KRTAP5-7
InteractionKRTAP4-5 interactions

LCE3D LCE2C LCE3E LCE2B

8.95e-0676354int:KRTAP4-5
InteractionKRTAP4-4 interactions

LCE3D LCE2C LCE3E LCE2B

1.15e-0581354int:KRTAP4-4
InteractionKRTAP10-6 interactions

LCE3D LCE2C LCE3E LCE2B

1.60e-0588354int:KRTAP10-6
InteractionKRTAP4-11 interactions

LCE3D LCE2C LCE3E LCE2B

1.91e-0592354int:KRTAP4-11
InteractionKRTAP5-6 interactions

LCE3D LCE2C LCE3E LCE2B

2.08e-0594354int:KRTAP5-6
InteractionKRTAP4-1 interactions

LCE3D LCE2C LCE3E

2.09e-0531353int:KRTAP4-1
InteractionKRTAP2-3 interactions

LCE3D LCE2C LCE3E LCE2B

2.17e-0595354int:KRTAP2-3
InteractionKRTAP9-8 interactions

LCE3D LCE2C LCE3E LCE2B

2.66e-05100354int:KRTAP9-8
InteractionKRTAP2-4 interactions

LCE3D LCE2C LCE3E LCE2B

2.76e-05101354int:KRTAP2-4
InteractionSPRY3 interactions

LCE3D LCE3E LCE2B

3.02e-0535353int:SPRY3
InteractionADAMTSL4 interactions

TRIP6 LCE3D LCE2C LCE3E LCE2B

3.45e-05217355int:ADAMTSL4
InteractionRGS20 interactions

LCE3D LCE2C LCE3E LCE2B

5.08e-05118354int:RGS20
InteractionKRTAP4-2 interactions

LCE3D LCE2C LCE3E LCE2B

7.87e-05132354int:KRTAP4-2
InteractionKRTAP17-1 interactions

LCE3D LCE2C LCE2B

7.87e-0548353int:KRTAP17-1
InteractionKRTAP9-3 interactions

LCE3D LCE2C LCE3E LCE2B

9.88e-05140354int:KRTAP9-3
InteractionTSPAN4 interactions

LCE3D SGPL1 LCE2B

1.06e-0453353int:TSPAN4
InteractionKRTAP12-3 interactions

LCE3D LCE2C LCE3E LCE2B

1.16e-04146354int:KRTAP12-3
InteractionTRIM42 interactions

LCE3D LCE2C LCE3E LCE2B

1.26e-04149354int:TRIM42
InteractionKRTAP9-2 interactions

LCE3D LCE2C LCE3E LCE2B

1.26e-04149354int:KRTAP9-2
InteractionKRTAP10-1 interactions

LCE3D LCE2C LCE3E LCE2B

1.39e-04153354int:KRTAP10-1
InteractionKRTAP10-5 interactions

LCE3D LCE2C LCE3E LCE2B

1.65e-04160354int:KRTAP10-5
InteractionVWC2 interactions

LCE3D LCE2C LCE3E

1.69e-0462353int:VWC2
InteractionKRTAP6-3 interactions

LCE3D LCE2C LCE3E LCE2B

1.69e-04161354int:KRTAP6-3
InteractionKRTAP4-12 interactions

LCE3D LCE2C LCE3E LCE2B

1.69e-04161354int:KRTAP4-12
InteractionCREB5 interactions

TRIP6 AGRN LCE2C RBCK1

1.82e-04164354int:CREB5
InteractionKRTAP10-11 interactions

LCE3D LCE3E LCE2B

1.86e-0464353int:KRTAP10-11
InteractionUNC80 interactions

PTPRK UNC80

1.91e-0412352int:UNC80
InteractionKRTAP5-11 interactions

LCE3D LCE2C LCE3E

2.04e-0466353int:KRTAP5-11
InteractionLCE3D interactions

LCE3D LCE2C LCE2B

2.75e-0473353int:LCE3D
InteractionCHIC2 interactions

LCE3D LCE2C LCE3E

2.75e-0473353int:CHIC2
InteractionKRTAP1-3 interactions

LCE3D LCE2C LCE3E LCE2B

2.82e-04184354int:KRTAP1-3
InteractionLCE2D interactions

LCE3D LCE2C LCE2B

2.86e-0474353int:LCE2D
InteractionLCE2B interactions

LCE3D LCE2C LCE2B

3.73e-0481353int:LCE2B
InteractionKRTAP3-3 interactions

LCE3D LCE3E LCE2B

3.87e-0482353int:KRTAP3-3
InteractionCES3 interactions

PTPRK MCU

3.92e-0417352int:CES3
InteractionKRTAP5-9 interactions

LCE3D LCE2C LCE3E LCE2B

4.10e-04203354int:KRTAP5-9
InteractionAPLNR interactions

RAB18 EDA SGPL1 MCU

4.74e-04211354int:APLNR
InteractionLCE2C interactions

LCE3D LCE2C LCE2B

4.76e-0488353int:LCE2C
InteractionRNF4 interactions

RAB18 PTPRK TRIP6 SGPL1 LCE2C MCU TMEM132A ZNF316 LCE2B

5.29e-041412359int:RNF4
InteractionKRTAP1-1 interactions

LCE3D LCE2C LCE3E LCE2B

5.45e-04219354int:KRTAP1-1
InteractionCLSTN2 interactions

MYCBP2 SGPL1

6.62e-0422352int:CLSTN2
InteractionNBPF19 interactions

LCE3D LCE2C LCE3E LCE2B

6.88e-04233354int:NBPF19
InteractionKRTAP10-9 interactions

LCE3D LCE2C LCE3E LCE2B

7.81e-04241354int:KRTAP10-9
InteractionSPRY1 interactions

LCE3D LCE2C LCE3E

9.36e-04111353int:SPRY1
InteractionPCSK5 interactions

PTPRK LCE3D LCE2C

9.61e-04112353int:PCSK5
InteractionALPK2 interactions

MYCBP2 TRIP6

1.00e-0327352int:ALPK2
CytobandEnsembl 112 genes in cytogenetic band chr1q21

LCE3D LCE2C LCE3E LCE2B

2.79e-04404364chr1q21
Cytoband7p22.1

TNRC18 ZNF316

6.32e-04473627p22.1
Cytoband1q21

LCE3D LCE2B

2.34e-03913621q21
Cytoband1q21.3

LCE2C LCE3E

3.83e-031173621q21.3
CytobandEnsembl 112 genes in cytogenetic band chr7p22

TNRC18 ZNF316

4.99e-03134362chr7p22
CytobandEnsembl 112 genes in cytogenetic band chr10p12

RAB18 PTF1A

5.43e-03140362chr10p12
GeneFamilyLate cornified envelope proteins

LCE3D LCE2C LCE3E LCE2B

7.22e-0918244627
GeneFamilyBasic helix-loop-helix proteins

NHLH1 OLIG1 PTF1A

4.04e-04110243420
GeneFamilyPotassium voltage-gated channels

KCNA6 KCNC2

1.28e-0340242274
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFHX3 ZNF282 FIZ1 ZNF316

1.39e-0271824428
ToppCellTCGA-Skin-Primary_Tumor|TCGA-Skin / Sample_Type by Project: Shred V9

DSG3 LCE3D LCE2C LCE3E LCE2B

4.32e-07190365e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCellTCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

DSG3 LCE3D LCE2C LCE3E LCE2B

4.32e-071903653188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCellTCGA-Skin-Primary_Tumor-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

DSG3 LCE3D LCE2C LCE3E LCE2B

4.32e-0719036501fb45add4661bc86cd0a34fac35177907152dbb
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

MYCBP2 DSG3 LCE3D LCE3E

7.51e-06156364ffb9249a115ce31f50b99a7a3d40bf48b9d7f2b0
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Metaplastic_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

LCE3D PTF1A LCE3E

2.59e-0571363ab476ee0b91d91d44d4324da18e2e7938bba3d2c
Diseasepsoriasis

LCE3D NOTCH4 LCE3E RUSC2

2.99e-04273354EFO_0000676
Diseasealcohol consumption measurement

ZFHX3 OLIG1 KCNC2 PTPRK TUSC1 AGRN TOPAZ1

5.50e-041242357EFO_0007878
Diseaseclinical treatment

MYCBP2 NOTCH4

1.09e-0341352EFO_0007056
Diseaseobesity (implicated_via_orthology)

ZFHX3 SGPL1 NOTCH4

2.10e-03215353DOID:9970 (implicated_via_orthology)
DiseaseR-warfarin measurement

RAB18 TUSC1 RUSC2

3.79e-03265353EFO_0803324
Diseaseorofacial cleft, sex interaction measurement

ZFHX3 NOTCH4

4.69e-0386352EFO_0008343, MONDO_0000358
Diseasesusceptibility to plantar warts measurement

NOTCH4 LCE3E

5.13e-0390352EFO_0008406
Diseasereaction time measurement

ZFHX3 KCNC2 PTPRK TOPAZ1

7.42e-03658354EFO_0008393

Protein segments in the cluster

PeptideGeneStartEntry
AGPCEQAECGSGGSG

AGRN

661

O00468
GACGGSDACDGSGDS

MKRN4P

71

Q13434
EEGQGGGACGGYCSV

RAB18

191

Q9NP72
FCNSGGGLGSGACAG

KRT26

56

Q7Z3Y9
CDCGAGSTGGVTGGF

DSG3

641

P32926
SPGPGGCFEGGAGNC

KCNC2

71

Q96PR1
GCFEGGAGNCSSRGG

KCNC2

76

Q96PR1
GGAGGCGALTAGCFP

MCU

21

Q8NE86
EVGGGAGVGTCCCGD

MST1L

296

Q2TV78
WGPGGPGDTSGGCRC

RBCK1

481

Q9BYM8
GGGAGGPGLCTCAVC

OLIG1

236

Q8TAK6
EPDDGGGGGYCCETG

PTF1A

91

Q7RTS3
GSQGCGCGGAPARAG

EDA

21

Q92838
SGFSDCGGGAGPDGA

NHLH1

21

Q02575
GDFPEAGGGGGCCSS

KCNA6

26

P17658
NVGPCSVCGGSGAGG

FIZ1

156

Q96SL8
CGPSSGGCCNSGAGG

LCE2B

56

O14633
CGPSSGGCCSSGAGG

LCE2C

56

Q5TA81
SGGCGPSSEGGCFLN

LCE3D

41

Q9BYE3
CDRGSGQQGGGSGCG

LCE3D

71

Q9BYE3
SGGCGPSSEGGCFLN

LCE3E

41

Q5T5B0
FSAGGCTFDDGPGAC

PTPRK

31

Q15262
CGAEGGGPGSGPFAD

RPP25

16

Q9BUL9
DRQCCGGAGGGGGST

RUSC2

26

Q8N2Y8
GAGGTGTGSGASCCP

TMEM121B

156

Q9BXQ6
GSCPCESGGGGEAPT

TMEM132A

921

Q24JP5
VPGGICGCGSGESGC

MYCBP2

791

O75592
GHFCGGWAGNCGDGG

MYCBP2

3276

O75592
RSGDGACDAGCSGPG

NOTCH4

1181

Q99466
FNGGPDSCGCVTSGG

SGPL1

196

O95470
GDGGCGTGGRNCSAA

TNRC18

2591

O15417
PSGEYFGQCGGCGED

TRIP6

271

Q15654
TCGFGGPAVSGAGDG

UNC80

726

Q8N2C7
GGAFCMCDVSGGGGE

ZNF516-DT

111

Q6ZTR6
GAAGGCGPEAGGCRE

TOPAZ1

31

Q8N9V7
TGLACDPFGGGGAAG

ZNF316

646

A6NFI3
AEAGTGAGGGCGSCC

ZNF282

486

Q9UDV7
GAGGGCGSCCPGGLR

ZNF282

491

Q9UDV7
SCCGGDGAADGRGPG

TUSC1

16

Q2TAM9
GGGGGGGSYHCLACE

ZFHX3

3521

Q15911