Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentAP-type membrane coat adaptor complex

SYNRG AP3D1

6.07e-0448162GO:0030119
GeneOntologyCellularComponentreceptor complex

AHR PLXNB2 GRIN2B CEACAM7

8.24e-04581164GO:0043235
GeneOntologyCellularComponenttranscription regulator complex

AHR ALX4 STAT2 STAT4

9.06e-04596164GO:0005667
GeneOntologyCellularComponentterminal bouton

AP3D1 GRIN2B

2.40e-0396162GO:0043195
GeneOntologyCellularComponentnuclear protein-containing complex

AHR DROSHA STAT2 STAT4 AFF2

2.91e-031377165GO:0140513
GeneOntologyCellularComponentmembrane coat

SYNRG AP3D1

2.92e-03106162GO:0030117
GeneOntologyCellularComponentcoated membrane

SYNRG AP3D1

2.92e-03106162GO:0048475
DomainSTAT_TF_prot_interaction

STAT2 STAT4

1.26e-057152IPR013799
DomainSTAT_TF_DNA-bd_sub

STAT2 STAT4

1.26e-057152IPR012345
DomainSTAT

STAT2 STAT4

1.26e-057152IPR001217
DomainSTAT_TF_coiled-coil

STAT2 STAT4

1.26e-057152IPR015988
DomainSTAT_int

STAT2 STAT4

1.26e-057152SM00964
Domain-

STAT2 STAT4

1.26e-0571522.60.40.630
Domain-

STAT2 STAT4

1.26e-0571521.10.532.10
DomainSTAT_TF_DNA-bd

STAT2 STAT4

1.26e-057152IPR013801
DomainSTAT_bind

STAT2 STAT4

1.26e-057152PF02864
DomainSTAT_alpha

STAT2 STAT4

1.26e-057152PF01017
DomainSTAT_int

STAT2 STAT4

1.26e-057152PF02865
Domain-

STAT2 STAT4

1.26e-0571521.20.1050.20
DomainSTAT_TF_alpha

STAT2 STAT4

1.68e-058152IPR013800
Domainp53-like_TF_DNA-bd

STAT2 STAT4

8.10e-0453152IPR008967
Domain-

SYNRG STAT2 STAT4

1.08e-032611531.10.238.10
DomainHEAT_REPEAT

SCYL2 AP3D1

1.41e-0370152PS50077
DomainEF-hand-dom_pair

SYNRG STAT2 STAT4

1.42e-03287153IPR011992
DomainSH2

STAT2 STAT4

2.90e-03101152PF00017
DomainIg_E-set

MYCBP2 PLXNB2

3.08e-03104152IPR014756
DomainSH2

STAT2 STAT4

3.43e-03110152SM00252
DomainSH2

STAT2 STAT4

3.49e-03111152PS50001
DomainSH2

STAT2 STAT4

3.56e-03112152IPR000980
Domain-

STAT2 STAT4

3.56e-031121523.30.505.10
Domain-

SCYL2 AP3D1

1.33e-022221521.25.10.10
Domain-

MYCBP2 PLXNB2 CEACAM7

1.47e-026631532.60.40.10
DomainIg-like_fold

MYCBP2 PLXNB2 CEACAM7

1.74e-02706153IPR013783
DomainARM-like

SCYL2 AP3D1

1.93e-02270152IPR011989
PathwayREACTOME_INTERLEUKIN_20_FAMILY_SIGNALING

STAT2 STAT4

2.94e-0426142M27750
PathwayPID_IL27_PATHWAY

STAT2 STAT4

2.94e-0426142M36
PathwayKEGG_MEDICUS_REFERENCE_IFN_RIPK1_3_SIGNALING_PATHWAY

STAT2 STAT4

4.19e-0431142M47964
PathwayKEGG_MEDICUS_REFERENCE_CYTOKINE_JAK_STAT_SIGNALING_PATHWAY

STAT2 STAT4

8.85e-0445142M47408
Pubmed

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.

STAT2 STAT4

1.98e-07216210881177
Pubmed

Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha.

STAT2 STAT4

5.95e-07316217015705
Pubmed

STATs as activators of apoptosis.

STAT2 STAT4

1.19e-0641629695817
Pubmed

STATs and gene regulation.

STAT2 STAT4

1.19e-0641629287210
Pubmed

High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.

STAT2 STAT4

1.98e-06516217846149
Pubmed

BART is essential for nuclear retention of STAT3.

STAT2 STAT4

1.98e-06516218234692
Pubmed

Association of STATs with relatives and friends.

STAT2 STAT4

2.97e-06616210675904
Pubmed

STAT heterodimers in immunity: A mixed message or a unique signal?

STAT2 STAT4

4.16e-06716224058793
Pubmed

JAK/STAT signaling by cytokine receptors.

STAT2 STAT4

4.16e-0671629638363
Pubmed

Expression and activation of STAT proteins during mouse retina development.

STAT2 STAT4

4.16e-06716212634107
Pubmed

The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).

STAT2 STAT4

4.16e-0671629342212
Pubmed

Physiological significance of STAT proteins: investigations through gene disruption in vivo.

STAT2 STAT4

4.16e-06716210526573
Pubmed

Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes.

SYNRG AP3D1

4.16e-06716216162817
Pubmed

STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.

STAT2 STAT4

4.16e-06716223797472
Pubmed

Signaling through the JAK/STAT pathway, recent advances and future challenges.

STAT2 STAT4

4.16e-06716212039028
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

SCYL2 AHR SYNRG DROSHA AP3D1 STAT2

4.32e-06103816626673895
Pubmed

JAK-STAT and bone metabolism.

STAT2 STAT4

8.91e-061016224069548
Pubmed

The Nab2 and Stat6 genes share a common transcription termination region.

STAT2 STAT4

8.91e-06101629126479
Pubmed

JAK-STAT signaling maintains homeostasis in T cells and macrophages.

STAT2 STAT4

8.91e-061016238658806
Pubmed

A T-bet gradient controls the fate and function of CCR6-RORĪ³t+ innate lymphoid cells.

AHR STAT4

8.91e-061016223334414
Pubmed

Cytokines, Jaks, Stats, health and disease.

STAT2 STAT4

8.91e-061016210200816
Pubmed

Distribution of the mammalian Stat gene family in mouse chromosomes.

STAT2 STAT4

1.54e-05131628530075
Pubmed

Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.

STAT2 STAT4

3.38e-051916232075740
Pubmed

Identification of Modifier Genes in a Mouse Model of Gaucher Disease.

GRIN2B AFF2

4.56e-052216227568557
Pubmed

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.

AHR STAT4

6.41e-052616233238123
Pubmed

Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.

STAT2 STAT4

6.92e-052716232428860
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MYCBP2 PLXNB2 SYNRG AP3D1 UBN1

1.05e-04110516535748872
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

SYNRG DROSHA STAT2 UBN1

1.25e-0458816438580884
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SCYL2 MYCBP2 COG1 DROSHA GRIN2B

2.12e-04128516535914814
Pubmed

A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis.

AHR ALX4

2.70e-045316238466355
Pubmed

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.

MYCBP2 SYNRG

2.70e-045316235216969
Pubmed

The IL-2 receptor beta chain gene (Il-2rb) is closely linked to the Pdgfb locus on mouse chromosome 15.

AHR CEACAM7

2.80e-04541628482578
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

SCYL2 SYNRG AP3D1

2.82e-0428516334369648
GeneFamilySH2 domain containing

STAT2 STAT4

1.64e-03101112741
ComputationalGenes in the cancer module 119.

MYCBP2 STAT2 STAT4

3.52e-04143113MODULE_119
DrugEtifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT_HG-U133A

SCYL2 MYCBP2 AP3D1 UBN1

6.11e-061781643998_DN
DrugPbTx-2

AHR GRIN2B

1.49e-0426162CID000002432
DrugICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A_EA

MYCBP2 AP3D1 UBN1

2.40e-04177163985_DN
DrugCaptopril [62571-86-2]; Down 200; 17.2uM; PC3; HT_HG-U133A

MYCBP2 AP3D1 UBN1

2.48e-041791634585_DN
DrugTetrandrine [518-34-3]; Up 200; 6.4uM; MCF7; HT_HG-U133A

STAT2 GRIN2B AFF2

2.73e-041851636082_UP
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

MYCBP2 AP3D1 UBN1

2.91e-041891631045_DN
DrugMethylprednisolone, 6-alpha [83-43-2]; Down 200; 10.6uM; PC3; HT_HG-U133A

PLXNB2 SYNRG UBN1

3.14e-041941637137_DN
DrugHemicholinium bromide [312-45-8]; Up 200; 7uM; PC3; HT_HG-U133A

SCYL2 STAT2 AFF2

3.14e-041941636739_UP
DrugLY 294002; Up 200; 10uM; HL60; HT_HG-U133A

STAT2 AFF2 CEACAM7

3.19e-041951632699_UP
DrugRetrorsine [480-54-6]; Up 200; 11.4uM; HL60; HT_HG-U133A

STAT2 STAT4 CEACAM7

3.29e-041971632129_UP
DrugNorfloxacin [70458-96-7]; Up 200; 12.6uM; MCF7; HT_HG-U133A

ALX4 STAT2 GRIN2B

3.29e-041971632253_UP
Drugtroglitazone; Up 200; 10uM; HL60; HT_HG-U133A

STAT2 AFF2 CEACAM7

3.29e-041971632692_UP
DrugDiltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; HL60; HG-U133A

AP3D1 STAT2 CEACAM7

3.34e-041981632032_UP
Drug6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; MCF7; HT_HG-U133A

ALX4 STAT2 CEACAM7

3.34e-041981636073_UP
Drugnitrendipine; Down 200; 10uM; MCF7; HG-U133A

AHR MYCBP2 AP3D1

3.34e-04198163336_DN
DrugScopolamin-N-oxide hydrobromide [6106-81-6]; Up 200; 10uM; HL60; HG-U133A

AP3D1 STAT4 AFF2

3.39e-041991631415_UP
Drugalpha-estradiol; Up 200; 0.01uM; PC3; HG-U133A

AHR STAT4 AFF2

3.44e-04200163702_UP
DrugTetrodotoxin

AHR GRIN2B

3.56e-0440162ctd:D013779
DrugOxadiazoles

AHR GRIN2B

4.31e-0444162ctd:D010069
Drugglucoheptose

AP3D1 AFF2

4.50e-0445162CID000076599
Drug1,4-bis-(phenoxyacetyl)piperazine

SCYL2 AP3D1 GRIN2B

4.85e-04225163CID001008511
Drug8-bromoguanine

AHR STAT2

6.25e-0453162CID000076473
DrugMDL 28170

AHR GRIN2B

6.49e-0454162CID000072430
DrugAC1NST48

SCYL2 COG1 SYNRG AP3D1

6.50e-04594164CID005315496
Diseasebrain disease (implicated_via_orthology)

MYCBP2 DROSHA

3.61e-066152DOID:936 (implicated_via_orthology)
DiseaseBehcet Syndrome

AHR STAT4

6.61e-0524152C0004943
Diseaseclinical treatment

MYCBP2 GRIN2B

1.96e-0441152EFO_0007056
DiseaseMale sterility

AHR DROSHA

2.68e-0448152C0917731
DiseaseMale infertility

AHR DROSHA

2.68e-0448152C0021364
DiseaseSubfertility, Male

AHR DROSHA

2.68e-0448152C0848676
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

PLXNB2 GRIN2B

2.80e-0449152DOID:0060037 (implicated_via_orthology)
Diseasenevus count, cutaneous melanoma

AHR PLXNB2

9.62e-0491152EFO_0000389, EFO_0004632
Diseasecutaneous melanoma

AHR PLXNB2

1.69e-03121152EFO_0000389

Protein segments in the cluster

PeptideGeneStartEntry
SFNKFQPQPSTPQPQ

ALX4

86

Q9H161
SNQFVPFNCPQQDPQ

AHR

656

P35869
SVPQNPNNKNEPSFF

AFF2

101

P51816
PKPSITSNNFNPVEN

CEACAM7

146

Q14002
QANNPFYIKSSPSPQ

AP3D1

676

O14617
PNVQFTFQQPKPLSV

PLXNB2

886

O15031
PRAQQPQQPSQEKFY

COG1

101

Q8WTW3
EQNFTNTVPQDPQPF

CCDC168

6196

Q8NDH2
NFPPPSFNSFQNNPS

DROSHA

176

Q9NRR4
SPNLQNQQFFSNPPK

STAT2

476

P52630
FPPSFPSGTIQQKQQ

SYNRG

591

Q9UMZ2
FFNPQNFAQPPTTMT

SCYL2

901

Q6P3W7
QKYAPPAFNPNQSTD

MYCBP2

1986

O75592
DSQNLVFFNNPPPAT

STAT4

476

Q14765
TQQQKNFTPPSPFAN

UBN1

811

Q9NPG3
QSNPCVPNNKNPRAF

GRIN2B

1451

Q13224